ANKDD1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.03866237
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37665035
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.32783353
4sphingoid metabolic process (GO:0046519)4.30481980
5negative regulation of hormone metabolic process (GO:0032351)4.06087538
6negative regulation of hormone biosynthetic process (GO:0032353)4.06087538
7regulation of clathrin-mediated endocytosis (GO:2000369)4.01894601
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.00092546
9positive regulation by symbiont of host defense response (GO:0052509)3.93440159
10modulation by symbiont of host defense response (GO:0052031)3.93440159
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.93440159
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.93440159
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.93440159
14modulation by symbiont of host immune response (GO:0052553)3.93440159
15sphingosine metabolic process (GO:0006670)3.89351989
16platelet dense granule organization (GO:0060155)3.85159504
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.84961586
18gamma-aminobutyric acid transport (GO:0015812)3.83669371
19cellular potassium ion homeostasis (GO:0030007)3.81090919
20synaptic transmission, glutamatergic (GO:0035249)3.79895386
21sodium ion export (GO:0071436)3.79599727
22DNA deamination (GO:0045006)3.76317957
23adaptation of signaling pathway (GO:0023058)3.73650171
24desmosome organization (GO:0002934)3.72580313
25synaptic vesicle maturation (GO:0016188)3.63195161
26regulation of ARF protein signal transduction (GO:0032012)3.54764247
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53475551
28regulation of glutamate receptor signaling pathway (GO:1900449)3.47201053
29regulation of synapse structural plasticity (GO:0051823)3.41077688
30diol metabolic process (GO:0034311)3.39390186
31detection of light stimulus involved in sensory perception (GO:0050962)3.38749559
32detection of light stimulus involved in visual perception (GO:0050908)3.38749559
33detection of bacterium (GO:0016045)3.30688074
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.29242885
35gonadal mesoderm development (GO:0007506)3.28929827
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.27139336
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24460628
38detection of other organism (GO:0098543)3.22592487
39positive regulation of vesicle fusion (GO:0031340)3.22552035
40fucose catabolic process (GO:0019317)3.21968015
41L-fucose metabolic process (GO:0042354)3.21968015
42L-fucose catabolic process (GO:0042355)3.21968015
43potassium ion homeostasis (GO:0055075)3.18480485
44neuron-neuron synaptic transmission (GO:0007270)3.16160729
45negative regulation of mast cell activation (GO:0033004)3.14220790
46potassium ion import (GO:0010107)3.10651874
47vesicle transport along microtubule (GO:0047496)3.07624278
48locomotory exploration behavior (GO:0035641)3.02696974
49cellular response to ATP (GO:0071318)3.00964600
50negative regulation of telomere maintenance (GO:0032205)2.97844849
51indole-containing compound catabolic process (GO:0042436)2.97388382
52indolalkylamine catabolic process (GO:0046218)2.97388382
53tryptophan catabolic process (GO:0006569)2.97388382
54vocalization behavior (GO:0071625)2.97219445
55modulation by symbiont of host cellular process (GO:0044068)2.94324984
56macrophage activation involved in immune response (GO:0002281)2.94238565
57cerebellar Purkinje cell differentiation (GO:0021702)2.92712735
58regulation of calcium ion-dependent exocytosis (GO:0017158)2.89724933
59synaptic vesicle docking involved in exocytosis (GO:0016081)2.89230284
60synaptic vesicle exocytosis (GO:0016079)2.88606774
61histone H3-K4 trimethylation (GO:0080182)2.85088629
62glutamate receptor signaling pathway (GO:0007215)2.84528567
63positive regulation of receptor recycling (GO:0001921)2.82999229
64low-density lipoprotein particle clearance (GO:0034383)2.82482332
65neuromuscular process controlling balance (GO:0050885)2.82285634
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82254736
67regulation of neuronal synaptic plasticity (GO:0048168)2.80921882
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78590313
69indolalkylamine metabolic process (GO:0006586)2.77269282
70response to pheromone (GO:0019236)2.76486422
71negative regulation of adenylate cyclase activity (GO:0007194)2.75341100
72regulation of dendritic spine morphogenesis (GO:0061001)2.74137834
73neuronal action potential (GO:0019228)2.73366533
74phosphatidylglycerol biosynthetic process (GO:0006655)2.73294695
75transmission of nerve impulse (GO:0019226)2.72348880
76positive regulation of interleukin-1 beta secretion (GO:0050718)2.71239288
77respiratory chain complex IV assembly (GO:0008535)2.68831230
78synaptic transmission, cholinergic (GO:0007271)2.68724998
79neuronal action potential propagation (GO:0019227)2.67591649
80regulation of synaptic vesicle exocytosis (GO:2000300)2.66749816
81behavioral response to ethanol (GO:0048149)2.66261857
82axoneme assembly (GO:0035082)2.66006383
83positive regulation of fibroblast migration (GO:0010763)2.65211111
84prepulse inhibition (GO:0060134)2.65027164
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64991616
86negative regulation of nucleotide biosynthetic process (GO:0030809)2.64735433
87negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.64735433
88negative regulation of amino acid transport (GO:0051956)2.64005489
89membrane depolarization during action potential (GO:0086010)2.63271977
90negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62469587
91regulation of interferon-beta biosynthetic process (GO:0045357)2.62040879
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62026682
93positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.59719780
94nerve growth factor signaling pathway (GO:0038180)2.59209536
95kynurenine metabolic process (GO:0070189)2.58107718
96preassembly of GPI anchor in ER membrane (GO:0016254)2.57983749
97membrane hyperpolarization (GO:0060081)2.57396268
98negative regulation of systemic arterial blood pressure (GO:0003085)2.56823996
99cytochrome complex assembly (GO:0017004)2.56779424
100negative regulation of cAMP biosynthetic process (GO:0030818)2.56706793
101negative regulation of cyclase activity (GO:0031280)2.56573322
102adult walking behavior (GO:0007628)2.54864354
103protein localization to cilium (GO:0061512)2.54231160
104anterograde synaptic vesicle transport (GO:0048490)2.54080653
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.53139705
106dendrite morphogenesis (GO:0048813)2.53027926
107L-amino acid import (GO:0043092)2.52630744
108piRNA metabolic process (GO:0034587)2.49365221
109phosphatidylinositol acyl-chain remodeling (GO:0036149)2.49200628
110positive regulation of neurotransmitter secretion (GO:0001956)2.48979476
111macroautophagy (GO:0016236)2.48978303
112antigen processing and presentation via MHC class Ib (GO:0002475)2.48928367
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.48649059
114positive regulation of interleukin-1 secretion (GO:0050716)2.47798006
115dopamine receptor signaling pathway (GO:0007212)2.47100588
116regulation of action potential (GO:0098900)2.46644474
117long-term memory (GO:0007616)2.45926429
118regulation of synaptic vesicle transport (GO:1902803)2.45666916
119positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.45446585
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45375696
121negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45340466
122positive regulation of neurotransmitter transport (GO:0051590)2.44890316
123regulation of acrosome reaction (GO:0060046)2.44566659
124negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.43213282
125glycine transport (GO:0015816)2.43081348
126regulation of vesicle fusion (GO:0031338)2.42117848
127positive regulation of antigen processing and presentation (GO:0002579)2.42099281
128axonal fasciculation (GO:0007413)2.41721091
129modulation by virus of host process (GO:0019054)2.41572804
130cellular sodium ion homeostasis (GO:0006883)2.41542804
131mannosylation (GO:0097502)2.41484172
132membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40181326
133negative regulation of cAMP metabolic process (GO:0030815)2.39117045
134regulation of Rap GTPase activity (GO:0032317)2.38986219
135regulation of neuron projection regeneration (GO:0070570)2.38831875
136regulation of axon regeneration (GO:0048679)2.38831875
137cAMP catabolic process (GO:0006198)2.38552106
138epithelial cilium movement (GO:0003351)2.37371322
139tryptophan metabolic process (GO:0006568)2.36993032
140auditory behavior (GO:0031223)2.36465688
141calcium ion import (GO:0070509)2.35998303
142indole-containing compound metabolic process (GO:0042430)2.35236590
143positive regulation of fatty acid transport (GO:2000193)2.33919258
144regulation of regulated secretory pathway (GO:1903305)2.33469214
145C4-dicarboxylate transport (GO:0015740)2.32611380
146regulation of long-term neuronal synaptic plasticity (GO:0048169)2.32603137
147negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.32248670
148regulation of Rac GTPase activity (GO:0032314)2.32241078
149cilium or flagellum-dependent cell motility (GO:0001539)2.32133683
150striatum development (GO:0021756)2.32008231
151positive regulation of prostaglandin secretion (GO:0032308)2.29509306
152mitotic cell cycle arrest (GO:0071850)2.27935440
153photoreceptor cell maintenance (GO:0045494)2.27741532
154negative regulation of interleukin-1 beta production (GO:0032691)2.25466674
155negative regulation of interleukin-1 production (GO:0032692)2.24047938
156multicellular organism reproduction (GO:0032504)2.23856786
157regulation of neurotransmitter uptake (GO:0051580)2.23015132
158amine catabolic process (GO:0009310)2.22912224
159cellular biogenic amine catabolic process (GO:0042402)2.22912224
160proline transport (GO:0015824)2.22740335
161interferon-gamma production (GO:0032609)2.22276019
162positive regulation of organic acid transport (GO:0032892)2.20493105
163auditory receptor cell stereocilium organization (GO:0060088)2.19731389
164retinal cone cell development (GO:0046549)2.19088747
165startle response (GO:0001964)2.17756937
166urinary tract smooth muscle contraction (GO:0014848)2.14851236
167microglial cell activation (GO:0001774)2.14520146
168positive regulation of CREB transcription factor activity (GO:0032793)2.14095771
169regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.13562722
170regulation of mesoderm development (GO:2000380)2.13220126
171regulation of interleukin-6 biosynthetic process (GO:0045408)2.12955973
172positive regulation of defense response to virus by host (GO:0002230)2.12925098
173cytidine metabolic process (GO:0046087)2.12873929
174cytidine catabolic process (GO:0006216)2.12873929
175cytidine deamination (GO:0009972)2.12873929
176ovulation cycle (GO:0042698)2.12211422
177cilium movement (GO:0003341)2.11326647
178regulation of cilium movement (GO:0003352)2.10604491
179glycosphingolipid biosynthetic process (GO:0006688)2.10476218
180activated T cell proliferation (GO:0050798)2.10193727
181cyclic nucleotide catabolic process (GO:0009214)2.10163154
182positive regulation of heat generation (GO:0031652)2.10084794
183regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.09547456
184phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.05223098
185opioid receptor signaling pathway (GO:0038003)2.04360062
186positive regulation of sodium ion transmembrane transport (GO:1902307)2.04018095
187protein polyglutamylation (GO:0018095)2.03355428
188NAD biosynthetic process (GO:0009435)2.02727802
189photoreceptor cell development (GO:0042461)2.02465408
190positive regulation of amino acid transport (GO:0051957)2.01099774
191purinergic nucleotide receptor signaling pathway (GO:0035590)2.00619434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.88727350
2ZNF274_21170338_ChIP-Seq_K562_Hela3.09962637
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.98268541
4DROSHA_22980978_ChIP-Seq_HELA_Human2.85640194
5VDR_22108803_ChIP-Seq_LS180_Human2.58127255
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56510288
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33204332
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.27291529
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13548887
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.05044851
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.02980829
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.99641163
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99554428
14IGF1R_20145208_ChIP-Seq_DFB_Human1.98295583
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85127216
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84787245
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81980897
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79490574
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78760438
20* P300_19829295_ChIP-Seq_ESCs_Human1.76113314
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76083327
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71793821
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70100340
24GBX2_23144817_ChIP-Seq_PC3_Human1.69992417
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65039073
26TAF15_26573619_Chip-Seq_HEK293_Human1.64390841
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62847664
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62724216
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62724216
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60576847
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59694265
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59694265
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56909837
34* KDM2B_26808549_Chip-Seq_K562_Human1.52951300
35ER_23166858_ChIP-Seq_MCF-7_Human1.52367228
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51570332
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.51322388
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50261747
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49779654
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48801549
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48054721
42BCAT_22108803_ChIP-Seq_LS180_Human1.47477090
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.47370053
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47180168
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46020637
46RXR_22108803_ChIP-Seq_LS180_Human1.45648875
47TP53_22573176_ChIP-Seq_HFKS_Human1.45549863
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.44117501
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41159426
50* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37920673
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37852563
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36446141
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36377950
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36302132
55EWS_26573619_Chip-Seq_HEK293_Human1.33713303
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33057640
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32358508
58FUS_26573619_Chip-Seq_HEK293_Human1.31974137
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.31839283
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31309048
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31144866
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.30847109
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30782522
64* SMAD3_21741376_ChIP-Seq_HESCs_Human1.29065625
65REST_21632747_ChIP-Seq_MESCs_Mouse1.28276034
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27990850
67AR_21572438_ChIP-Seq_LNCaP_Human1.27474159
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26405218
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25350088
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.24506265
71AHR_22903824_ChIP-Seq_MCF-7_Human1.24495823
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.23890744
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23687135
74SPI1_23127762_ChIP-Seq_K562_Human1.23485988
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23034863
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.22699628
77TCF4_23295773_ChIP-Seq_U87_Human1.22400627
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.20306599
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.20240585
80* GATA3_21878914_ChIP-Seq_MCF-7_Human1.19923157
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19744779
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.18753156
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.17889839
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17889839
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17823992
86CBP_20019798_ChIP-Seq_JUKART_Human1.17823992
87* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15731360
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.15646061
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14762704
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14128533
91SOX2_19829295_ChIP-Seq_ESCs_Human1.13702181
92NANOG_19829295_ChIP-Seq_ESCs_Human1.13702181
93GATA1_22025678_ChIP-Seq_K562_Human1.12740807
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12429692
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11793741
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10981209
97SMAD4_21799915_ChIP-Seq_A2780_Human1.10849834
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10059677
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09020577
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.07749667
101TCF4_22108803_ChIP-Seq_LS180_Human1.07731683
102AR_25329375_ChIP-Seq_VCAP_Human1.07578664
103* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07558329
104* RUNX2_22187159_ChIP-Seq_PCA_Human1.07338675
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.06513782
106AR_20517297_ChIP-Seq_VCAP_Human1.06501374
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05950719
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05006114
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04253302
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.03969375
111* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03634543
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03158040
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02526172
114RNF2_27304074_Chip-Seq_NSC_Mouse1.02475489
115MYC_19829295_ChIP-Seq_ESCs_Human1.02468040
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.02453565
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.02355628
118ERA_21632823_ChIP-Seq_H3396_Human1.00881105
119TP53_18474530_ChIP-ChIP_U2OS_Human0.99658071
120NCOR_22424771_ChIP-Seq_293T_Human0.99453507
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98916348
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98706847
123EZH2_27304074_Chip-Seq_ESCs_Mouse0.98451309
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98302640
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98286748
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97794396
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97562584
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97433029
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97251889
130STAT3_23295773_ChIP-Seq_U87_Human0.96690015
131IRF1_19129219_ChIP-ChIP_H3396_Human0.96366162
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96237587
133GATA1_19941826_ChIP-Seq_K562_Human0.96199593
134STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96063483
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95697766
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94778772
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94738610
138SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94438104
139* VDR_24787735_ChIP-Seq_THP-1_Human0.93258169
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93010406
141AR_19668381_ChIP-Seq_PC3_Human0.92842804
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.92308013
143TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92042837
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91514886
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91385136
146EED_16625203_ChIP-ChIP_MESCs_Mouse0.90614509
147FOXA2_19822575_ChIP-Seq_HepG2_Human0.90587983
148* SMAD3_21741376_ChIP-Seq_EPCs_Human0.90246156
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90197157
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.90171903
151YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89887931
152OCT1_27270436_Chip-Seq_PROSTATE_Human0.89513261
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89372698
154* KDM2B_26808549_Chip-Seq_JURKAT_Human0.86374608
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86028566
156NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85808467
157TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85499234
158TP63_23658742_ChIP-Seq_EP156T_Human0.84839052
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83333041
160KLF5_25053715_ChIP-Seq_YYC3_Human0.83158749
161* SMAD4_21741376_ChIP-Seq_HESCs_Human0.82573252
162GATA2_19941826_ChIP-Seq_K562_Human0.82573201
163PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81543921
164TP63_22573176_ChIP-Seq_HFKS_Human0.81406096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.92314676
2MP0000569_abnormal_digit_pigmentation4.38741025
3MP0003880_abnormal_central_pattern4.06617659
4MP0010386_abnormal_urinary_bladder3.96851100
5MP0002822_catalepsy3.11991261
6MP0001968_abnormal_touch/_nociception2.92764635
7MP0002102_abnormal_ear_morphology2.86826346
8MP0003635_abnormal_synaptic_transmissio2.71245767
9MP0003172_abnormal_lysosome_physiology2.47918403
10MP0009745_abnormal_behavioral_response2.27627121
11MP0000604_amyloidosis2.25182273
12MP0005551_abnormal_eye_electrophysiolog2.22294724
13MP0002063_abnormal_learning/memory/cond2.21601507
14MP0005058_abnormal_lysosome_morphology2.20877537
15MP0002736_abnormal_nociception_after2.12483922
16MP0002064_seizures2.11481586
17MP0003303_peritoneal_inflammation2.06415894
18MP0008877_abnormal_DNA_methylation2.06224090
19MP0001986_abnormal_taste_sensitivity2.04537151
20MP0002796_impaired_skin_barrier2.02476160
21MP0005671_abnormal_response_to2.02275488
22MP0009046_muscle_twitch2.01783788
23MP0002254_reproductive_system_inflammat2.01445611
24MP0004947_skin_inflammation1.96502753
25MP0010234_abnormal_vibrissa_follicle1.96014671
26MP0004742_abnormal_vestibular_system1.94183157
27MP0002653_abnormal_ependyma_morphology1.87517463
28MP0003195_calcinosis1.81487849
29MP0001501_abnormal_sleep_pattern1.81413445
30MP0003075_altered_response_to1.76640742
31MP0002572_abnormal_emotion/affect_behav1.75771535
32MP0002734_abnormal_mechanical_nocicepti1.74341067
33MP0004510_myositis1.73449773
34MP0003566_abnormal_cell_adhesion1.72776929
35MP0003191_abnormal_cellular_cholesterol1.70608676
36MP0002909_abnormal_adrenal_gland1.66946542
37MP0001835_abnormal_antigen_presentation1.66218736
38MP0003724_increased_susceptibility_to1.66080471
39MP0002638_abnormal_pupillary_reflex1.59906305
40MP0008875_abnormal_xenobiotic_pharmacok1.59803068
41MP0004858_abnormal_nervous_system1.56778420
42MP0004270_analgesia1.55228682
43MP0003690_abnormal_glial_cell1.52900620
44MP0004185_abnormal_adipocyte_glucose1.51904215
45MP0001486_abnormal_startle_reflex1.51087429
46MP0004142_abnormal_muscle_tone1.50749330
47MP0006276_abnormal_autonomic_nervous1.50705156
48MP0008872_abnormal_physiological_respon1.47207269
49MP0002234_abnormal_pharynx_morphology1.44723223
50MP0002277_abnormal_respiratory_mucosa1.44685641
51MP0002272_abnormal_nervous_system1.44226232
52MP0001905_abnormal_dopamine_level1.44110046
53MP0002138_abnormal_hepatobiliary_system1.44109579
54MP0008874_decreased_physiological_sensi1.43851660
55MP0005310_abnormal_salivary_gland1.42464169
56MP0006072_abnormal_retinal_apoptosis1.40846252
57MP0004043_abnormal_pH_regulation1.40831630
58MP0001440_abnormal_grooming_behavior1.36334470
59MP0009780_abnormal_chondrocyte_physiolo1.36171146
60MP0005377_hearing/vestibular/ear_phenot1.34883157
61MP0003878_abnormal_ear_physiology1.34883157
62MP0003300_gastrointestinal_ulcer1.34651174
63MP0003329_amyloid_beta_deposits1.34200920
64MP0005253_abnormal_eye_physiology1.33575927
65MP0002733_abnormal_thermal_nociception1.32004015
66MP0001970_abnormal_pain_threshold1.30716364
67MP0002735_abnormal_chemical_nociception1.28589542
68MP0003136_yellow_coat_color1.28556864
69MP0003436_decreased_susceptibility_to1.27278501
70MP0004130_abnormal_muscle_cell1.26698655
71MP0003787_abnormal_imprinting1.25103782
72MP0001485_abnormal_pinna_reflex1.24545318
73MP0005367_renal/urinary_system_phenotyp1.22340874
74MP0000516_abnormal_urinary_system1.22340874
75MP0005084_abnormal_gallbladder_morpholo1.21967158
76MP0009840_abnormal_foam_cell1.20824059
77MP0000685_abnormal_immune_system1.20507166
78MP0000372_irregular_coat_pigmentation1.20013570
79MP0005387_immune_system_phenotype1.19720050
80MP0001790_abnormal_immune_system1.19720050
81MP0003283_abnormal_digestive_organ1.18729730
82MP0003453_abnormal_keratinocyte_physiol1.18127907
83MP0005646_abnormal_pituitary_gland1.17957978
84MP0002067_abnormal_sensory_capabilities1.17759424
85MP0000631_abnormal_neuroendocrine_gland1.13851288
86MP0002148_abnormal_hypersensitivity_rea1.12769846
87MP0003879_abnormal_hair_cell1.11682258
88MP0009764_decreased_sensitivity_to1.10627932
89MP0005645_abnormal_hypothalamus_physiol1.10624822
90MP0004133_heterotaxia1.07818047
91MP0003646_muscle_fatigue1.07698157
92MP0004885_abnormal_endolymph1.07049334
93MP0005075_abnormal_melanosome_morpholog1.06924158
94MP0004811_abnormal_neuron_physiology1.06700253
95MP0006292_abnormal_olfactory_placode1.06612559
96MP0003137_abnormal_impulse_conducting1.05467288
97MP0001851_eye_inflammation1.04984082
98MP0002090_abnormal_vision1.04015024
99MP0001800_abnormal_humoral_immune1.03767135
100MP0002928_abnormal_bile_duct1.01912138
101MP0002419_abnormal_innate_immunity1.01678574
102MP0003183_abnormal_peptide_metabolism1.01393321
103MP0008569_lethality_at_weaning1.00856959
104MP0003633_abnormal_nervous_system1.00140477
105MP0005166_decreased_susceptibility_to0.95140934
106MP0001984_abnormal_olfaction0.95029350
107MP0002557_abnormal_social/conspecific_i0.95007591
108MP0010771_integument_phenotype0.93986829
109MP0000230_abnormal_systemic_arterial0.91683546
110MP0001177_atelectasis0.89545687
111MP0005448_abnormal_energy_balance0.88667641
112MP0000538_abnormal_urinary_bladder0.88616265
113MP0005464_abnormal_platelet_physiology0.88236159
114MP0002723_abnormal_immune_serum0.87744788
115MP0000465_gastrointestinal_hemorrhage0.87099537
116MP0005647_abnormal_sex_gland0.86263418
117MP0005535_abnormal_body_temperature0.85826252
118MP0001963_abnormal_hearing_physiology0.85035338
119MP0008260_abnormal_autophagy0.84579761
120MP0005000_abnormal_immune_tolerance0.84394824
121MP0006082_CNS_inflammation0.83758843
122MP0004145_abnormal_muscle_electrophysio0.83695792
123MP0005275_abnormal_skin_tensile0.83472805
124MP0002229_neurodegeneration0.82535134
125MP0001873_stomach_inflammation0.82502344
126MP0004215_abnormal_myocardial_fiber0.81460307
127MP0002752_abnormal_somatic_nervous0.81432911
128MP0002452_abnormal_antigen_presenting0.80412275
129MP0002933_joint_inflammation0.79362439
130MP0000026_abnormal_inner_ear0.79150883
131MP0003091_abnormal_cell_migration0.77673373
132MP0005423_abnormal_somatic_nervous0.77524763
133MP0010678_abnormal_skin_adnexa0.77443041
134MP0004924_abnormal_behavior0.77419179
135MP0005386_behavior/neurological_phenoty0.77419179
136MP0003631_nervous_system_phenotype0.77301351
137MP0000920_abnormal_myelination0.76231505
138MP0000955_abnormal_spinal_cord0.75076685
139MP0003632_abnormal_nervous_system0.74628552
140MP0002876_abnormal_thyroid_physiology0.74601991
141MP0003045_fibrosis0.71100921
142MP0001346_abnormal_lacrimal_gland0.70955643
143MP0005174_abnormal_tail_pigmentation0.69185711
144MP0003634_abnormal_glial_cell0.67186417
145MP0002882_abnormal_neuron_morphology0.66805261
146MP0001502_abnormal_circadian_rhythm0.66391627
147MP0001533_abnormal_skeleton_physiology0.66009262
148MP0005501_abnormal_skin_physiology0.65731790
149MP0004484_altered_response_of0.65430274
150MP0002184_abnormal_innervation0.65320324
151MP0002066_abnormal_motor_capabilities/c0.65009493
152MP0005076_abnormal_cell_differentiation0.62905246
153MP0003011_delayed_dark_adaptation0.62873978
154MP0005167_abnormal_blood-brain_barrier0.62626172
155MP0002837_dystrophic_cardiac_calcinosis0.62188001
156MP0005451_abnormal_body_composition0.60509367

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.80767168
2Myokymia (HP:0002411)5.36330662
3Increased cerebral lipofuscin (HP:0011813)4.11516329
4Progressive cerebellar ataxia (HP:0002073)3.86635531
5Molar tooth sign on MRI (HP:0002419)3.85993672
6Abnormality of midbrain morphology (HP:0002418)3.85993672
7Congenital stationary night blindness (HP:0007642)3.79893977
8Pancreatic cysts (HP:0001737)3.79586399
9Focal seizures (HP:0007359)3.76598889
10Nephronophthisis (HP:0000090)3.65025853
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.59319475
12Genetic anticipation (HP:0003743)3.52876779
13Hyperventilation (HP:0002883)3.51279830
14Pancreatic fibrosis (HP:0100732)3.49866268
15True hermaphroditism (HP:0010459)3.45492611
16Parakeratosis (HP:0001036)3.40207835
17Long toe (HP:0010511)3.37242378
18Global brain atrophy (HP:0002283)3.33280930
19Abnormal rod and cone electroretinograms (HP:0008323)3.32540452
20Abnormality of binocular vision (HP:0011514)3.27269955
21Diplopia (HP:0000651)3.27269955
22Visual hallucinations (HP:0002367)3.24758142
23Hemiplegia (HP:0002301)3.23544344
24Abnormality of the renal medulla (HP:0100957)3.14143917
25Febrile seizures (HP:0002373)3.10117200
26Mutism (HP:0002300)3.09502957
27Decreased central vision (HP:0007663)3.07354548
28Abnormality of the renal cortex (HP:0011035)2.98080118
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97022071
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.96007562
31Type II lissencephaly (HP:0007260)2.93549902
32Attenuation of retinal blood vessels (HP:0007843)2.92741918
33Recurrent bacterial skin infections (HP:0005406)2.85764060
34Abolished electroretinogram (ERG) (HP:0000550)2.82126917
35Absent/shortened dynein arms (HP:0200106)2.81968527
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.81968527
37Recurrent abscess formation (HP:0002722)2.78357471
38Action tremor (HP:0002345)2.77174948
39Urinary bladder sphincter dysfunction (HP:0002839)2.76887064
40Supranuclear gaze palsy (HP:0000605)2.75773220
41Generalized tonic-clonic seizures (HP:0002069)2.71354521
42Tubular atrophy (HP:0000092)2.69798930
43Abnormality of polysaccharide metabolism (HP:0011012)2.69349688
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.69349688
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.69349688
46Axonal loss (HP:0003447)2.69097023
47Stomatitis (HP:0010280)2.67875048
48Neuronal loss in central nervous system (HP:0002529)2.67561506
49Vacuolated lymphocytes (HP:0001922)2.64994438
50Gaze-evoked nystagmus (HP:0000640)2.62835910
51Abnormal drinking behavior (HP:0030082)2.62376200
52Polydipsia (HP:0001959)2.62376200
53Abnormality of liposaccharide metabolism (HP:0010968)2.61950627
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.61950627
55Abnormality of glycolipid metabolism (HP:0010969)2.61950627
56Medial flaring of the eyebrow (HP:0010747)2.59911951
57Absent speech (HP:0001344)2.58051456
58Mediastinal lymphadenopathy (HP:0100721)2.57702359
59Spastic tetraparesis (HP:0001285)2.54769982
60Recurrent gram-negative bacterial infections (HP:0005420)2.54452244
61Postural instability (HP:0002172)2.53717045
62Lip pit (HP:0100267)2.52142919
63Dysmetric saccades (HP:0000641)2.51303324
64Amyloidosis (HP:0011034)2.51018307
65Neurofibrillary tangles (HP:0002185)2.46318415
66Akinesia (HP:0002304)2.43745341
67Disinhibition (HP:0000734)2.40279172
68Inability to walk (HP:0002540)2.39392082
69Decreased circulating renin level (HP:0003351)2.31596750
70Pendular nystagmus (HP:0012043)2.28937991
71Dysdiadochokinesis (HP:0002075)2.28289732
72Chronic sinusitis (HP:0011109)2.28183549
73Chronic otitis media (HP:0000389)2.28020267
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25485763
75Clumsiness (HP:0002312)2.24882732
76Bony spicule pigmentary retinopathy (HP:0007737)2.24211467
77Gait imbalance (HP:0002141)2.24020858
78Abnormal ciliary motility (HP:0012262)2.23953155
79Aplasia involving bones of the upper limbs (HP:0009823)2.22971349
80Aplasia of the phalanges of the hand (HP:0009802)2.22971349
81Aplasia involving bones of the extremities (HP:0009825)2.22971349
82Lower limb amyotrophy (HP:0007210)2.22354019
83Polyuria (HP:0000103)2.21869427
84Abnormal respiratory motile cilium morphology (HP:0005938)2.21483382
85Abnormal respiratory epithelium morphology (HP:0012253)2.21483382
86Mucopolysacchariduria (HP:0008155)2.20762830
87Urinary glycosaminoglycan excretion (HP:0003541)2.20762830
88Dialeptic seizures (HP:0011146)2.19609562
89Elevated erythrocyte sedimentation rate (HP:0003565)2.19552475
90Torticollis (HP:0000473)2.18873456
91Loss of speech (HP:0002371)2.18708798
92Rib fusion (HP:0000902)2.17735015
93Chronic hepatic failure (HP:0100626)2.17049261
94Large for gestational age (HP:0001520)2.15999448
95Stomach cancer (HP:0012126)2.15354954
963-Methylglutaconic aciduria (HP:0003535)2.13851878
97Cerebral inclusion bodies (HP:0100314)2.12659719
98Cystic liver disease (HP:0006706)2.12215556
99Progressive inability to walk (HP:0002505)2.10328241
100Anhidrosis (HP:0000970)2.09423410
101Intention tremor (HP:0002080)2.08559695
102Polyphagia (HP:0002591)2.06789566
103Protruding tongue (HP:0010808)2.06056929
104Congenital primary aphakia (HP:0007707)2.03612005
105Urticaria (HP:0001025)2.03185475
106Gingivitis (HP:0000230)2.01454122
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01202949
108Hemiparesis (HP:0001269)2.00525194
109Impaired smooth pursuit (HP:0007772)2.00396890
110Impaired social interactions (HP:0000735)2.00110644
111Abnormal social behavior (HP:0012433)2.00110644
112Abnormality of the 2nd finger (HP:0004100)1.99788842
113Ankle clonus (HP:0011448)1.98998792
114Dysostosis multiplex (HP:0000943)1.98321698
115Distal lower limb amyotrophy (HP:0008944)1.98281492
116Sparse lateral eyebrow (HP:0005338)1.97164642
117Craniofacial dystonia (HP:0012179)1.96242030
118Dysmetria (HP:0001310)1.95613798
119Depression (HP:0000716)1.94468927
120Apathy (HP:0000741)1.94390403
121Tubulointerstitial fibrosis (HP:0005576)1.93643468
122Renal cortical cysts (HP:0000803)1.93626677
123Keratoconus (HP:0000563)1.93608497
124Increased corneal curvature (HP:0100692)1.93608497
125Epileptic encephalopathy (HP:0200134)1.92597435
126Focal dystonia (HP:0004373)1.92595702
127Broad-based gait (HP:0002136)1.92402891
128Abnormal respiratory motile cilium physiology (HP:0012261)1.92078606
129Retinal dysplasia (HP:0007973)1.91533167
130Palmoplantar hyperkeratosis (HP:0000972)1.90563797
131Sclerocornea (HP:0000647)1.90094646
132Premature loss of primary teeth (HP:0006323)1.89529414
133Leiomyosarcoma (HP:0100243)1.88865172
134Uterine leiomyosarcoma (HP:0002891)1.88865172
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.87232515
136Mesangial abnormality (HP:0001966)1.86648613
137Congenital hepatic fibrosis (HP:0002612)1.86600510
138Atonic seizures (HP:0010819)1.86431380
139Aortic aneurysm (HP:0004942)1.86227270
140Absence seizures (HP:0002121)1.86136670
141Eczematoid dermatitis (HP:0000976)1.86034004
142Nephrogenic diabetes insipidus (HP:0009806)1.85965322
143Mitochondrial inheritance (HP:0001427)1.85848587
144Abnormality of macrophages (HP:0004311)1.85845311
145Neoplasm of the heart (HP:0100544)1.85018383
146Inappropriate behavior (HP:0000719)1.84007165
147Abnormal biliary tract physiology (HP:0012439)1.82900853
148Bile duct proliferation (HP:0001408)1.82900853
149Absent frontal sinuses (HP:0002688)1.82419156
150Abnormality of vision evoked potentials (HP:0000649)1.81075561
151Progressive sensorineural hearing impairment (HP:0000408)1.81010688
152Abnormal urine output (HP:0012590)1.80968683
153Dyskinesia (HP:0100660)1.80202400
154Progressive hearing impairment (HP:0001730)1.79961865
155Optic disc pallor (HP:0000543)1.79730504
156Polygenic inheritance (HP:0010982)1.79471170
157Genital tract atresia (HP:0001827)1.79373831
158Male pseudohermaphroditism (HP:0000037)1.79237147
159Slow saccadic eye movements (HP:0000514)1.78135556
160Abnormality of alanine metabolism (HP:0010916)1.77630705
161Hyperalaninemia (HP:0003348)1.77630705
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77630705
163Drooling (HP:0002307)1.77424981
164Excessive salivation (HP:0003781)1.77424981
165Anencephaly (HP:0002323)1.76103514
166Recurrent bronchitis (HP:0002837)1.75623236
167Constricted visual fields (HP:0001133)1.75549321
168Poor eye contact (HP:0000817)1.75389541
169Turricephaly (HP:0000262)1.75264948
170Retinitis pigmentosa (HP:0000510)1.75240275
171Pointed chin (HP:0000307)1.75228094
172Male infertility (HP:0003251)1.75054205
173Anterior segment dysgenesis (HP:0007700)1.73878109
174Bladder carcinoma (HP:0002862)1.73805531
175Bladder neoplasm (HP:0009725)1.73805531
176Diminished motivation (HP:0000745)1.73658512
177Hepatocellular necrosis (HP:0001404)1.73310218
178Tachypnea (HP:0002789)1.73267031
179Achilles tendon contracture (HP:0001771)1.72868605
180Increased CSF lactate (HP:0002490)1.72251363
181Optic nerve hypoplasia (HP:0000609)1.71582588
182Severe visual impairment (HP:0001141)1.71430569
183Abnormality of macular pigmentation (HP:0008002)1.71320281
184Aplasia/Hypoplasia of the tibia (HP:0005772)1.69765290
185Bulbous nose (HP:0000414)1.68586308
186Optic neuritis (HP:0100653)1.67810667
187Retrobulbar optic neuritis (HP:0100654)1.67810667
188Abnormal eating behavior (HP:0100738)1.65225166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.71272195
2NTRK33.76526475
3FES3.32194223
4MAP3K62.88869112
5ADRBK22.85249039
6RIPK42.72259174
7MAP3K132.71973839
8BMPR1B2.36626898
9NUAK12.31458955
10MAP3K92.26171931
11MAP4K22.19284057
12TAOK32.17284263
13TAOK12.16701088
14GRK12.11563018
15MAPK132.09117148
16WNK32.08492226
17ACVR1B2.02207719
18CDK121.95460866
19WNK41.90143997
20MAP3K41.89686795
21KSR21.89079870
22CAMKK21.72241912
23FER1.72109912
24TTN1.71241370
25DAPK21.68622494
26PAK61.65941087
27LATS11.63444087
28CASK1.63070487
29CAMKK11.62784860
30MAP2K71.61824875
31GRK71.60209131
32INSRR1.55923423
33TLK11.54389182
34STK381.49452102
35MAP3K21.47097370
36CAMK1D1.45242630
37DMPK1.41479335
38NTRK21.36966957
39MAP2K41.31256555
40RAF11.28321566
41EEF2K1.26906805
42ADRBK11.25444769
43MOS1.23939445
44MAP4K11.23665352
45PAK31.20192217
46MAP3K51.18988548
47TNIK1.18076962
48TXK1.17310859
49LATS21.11794019
50TGFBR21.11366865
51ERN11.10832771
52MAP3K111.07140371
53ABL21.06992826
54CAMK11.02630757
55GRK51.02128274
56PTK2B1.01457981
57MAP3K141.01218148
58PRKCG0.98841462
59BMPR20.97031972
60CDK50.92253559
61MINK10.90679950
62SYK0.90388245
63PRKD20.90238529
64MAPK150.89806137
65RET0.89578976
66IRAK40.89413060
67PTK60.89391934
68LMTK20.89180820
69RPS6KA20.87472306
70MATK0.87299974
71SIK20.87118216
72NTRK10.86321486
73IRAK10.85984163
74BCKDK0.85816923
75EPHA30.84319716
76DYRK20.84130732
77HCK0.83275382
78ARAF0.82994898
79PDGFRB0.82571171
80KSR10.79109102
81MARK20.78134776
82CAMK1G0.77753097
83BLK0.77710595
84PRKCQ0.76643007
85SGK10.75051366
86PIK3CG0.74902485
87RIPK10.73245364
88MAP3K30.73103130
89TGFBR10.72514110
90SGK20.72070275
91TNK20.70734463
92MAP2K60.69712383
93CSNK1G20.69399934
94STK390.69371413
95SGK30.69165463
96MKNK20.67718779
97PRKCI0.65326675
98MAPKAPK30.64866977
99IRAK20.64417193
100JAK20.64254137
101CSNK1A1L0.63170328
102MST1R0.62946507
103TYRO30.62016167
104TRPM70.61760098
105CHUK0.61524726
106IRAK30.61151702
107STK160.60857709
108SGK2230.60436113
109SGK4940.60436113
110LYN0.59598017
111MAP3K70.59477652
112CSK0.59433301
113CSNK1G30.59246257
114ERBB40.59232479
115AKT30.56298114
116JAK10.55585447
117ZAK0.55399643
118IKBKE0.54489727
119DYRK30.54272933
120PRKD30.54137201
121MARK10.53303676
122FGR0.51771555
123PRKCZ0.51734065
124CDC42BPA0.51454485
125DDR20.50980391
126PLK20.50485955
127PKN10.50308856
128TBK10.49544345
129TEC0.49103471
130STK100.49023150
131VRK20.48508656
132CSNK1G10.47969076
133PDK10.47699086
134TIE10.47486100
135ITK0.47195330
136CAMK2B0.46752118
137OXSR10.45210360
138PRKCH0.45108764
139CAMK2D0.44951045
140PRKG10.44196936
141FRK0.44100950
142LCK0.43374101
143PRKACA0.43213935
144PINK10.42629777
145CAMK40.42517028
146FYN0.41965495
147BRAF0.39742270
148MAP3K10.39692980
149FGFR20.39484504
150CDK190.39374528
151RPS6KA30.38939442
152PDPK10.38611585
153CSF1R0.38484449
154MELK0.38044170
155CAMK2A0.37781298
156TRIB30.37731040
157NME10.37610796
158ERBB20.36412401
159DAPK30.35973136
160ABL10.35821063
161MAPK100.34154658
162IKBKB0.32625727
163STK110.31840345
164DAPK10.31277853
165PRKCE0.30134365
166KIT0.28803504
167RPS6KB10.28351478

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.80751885
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.63935955
3Phototransduction_Homo sapiens_hsa047442.60891592
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49253877
5Asthma_Homo sapiens_hsa053102.40039661
6Nicotine addiction_Homo sapiens_hsa050332.37558789
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.28150544
8Linoleic acid metabolism_Homo sapiens_hsa005912.21684073
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12177740
10Primary immunodeficiency_Homo sapiens_hsa053401.94448041
11Type II diabetes mellitus_Homo sapiens_hsa049301.94034810
12Oxidative phosphorylation_Homo sapiens_hsa001901.92164126
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89958546
14Allograft rejection_Homo sapiens_hsa053301.88588566
15Morphine addiction_Homo sapiens_hsa050321.87207679
16GABAergic synapse_Homo sapiens_hsa047271.85825606
17Circadian entrainment_Homo sapiens_hsa047131.84566633
18Collecting duct acid secretion_Homo sapiens_hsa049661.84027078
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.83553875
20Glutamatergic synapse_Homo sapiens_hsa047241.82418355
21Olfactory transduction_Homo sapiens_hsa047401.72393120
22Ether lipid metabolism_Homo sapiens_hsa005651.68258631
23Autoimmune thyroid disease_Homo sapiens_hsa053201.67556803
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64412753
25Nitrogen metabolism_Homo sapiens_hsa009101.62325165
26Graft-versus-host disease_Homo sapiens_hsa053321.60933902
27Long-term potentiation_Homo sapiens_hsa047201.55688821
28Cholinergic synapse_Homo sapiens_hsa047251.54517900
29Sphingolipid metabolism_Homo sapiens_hsa006001.51663811
30Long-term depression_Homo sapiens_hsa047301.46953372
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46100541
32Salivary secretion_Homo sapiens_hsa049701.44650408
33Type I diabetes mellitus_Homo sapiens_hsa049401.43220208
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40903134
35Lysosome_Homo sapiens_hsa041421.39376766
36Dopaminergic synapse_Homo sapiens_hsa047281.39030227
37Parkinsons disease_Homo sapiens_hsa050121.36724771
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35866642
39Caffeine metabolism_Homo sapiens_hsa002321.32891585
40Tryptophan metabolism_Homo sapiens_hsa003801.31063908
41Oxytocin signaling pathway_Homo sapiens_hsa049211.30517155
42GnRH signaling pathway_Homo sapiens_hsa049121.29702043
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27157671
44Gastric acid secretion_Homo sapiens_hsa049711.24653813
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24614217
46cAMP signaling pathway_Homo sapiens_hsa040241.23632493
47Amphetamine addiction_Homo sapiens_hsa050311.22334133
48Choline metabolism in cancer_Homo sapiens_hsa052311.22079082
49Dorso-ventral axis formation_Homo sapiens_hsa043201.21898285
50Sphingolipid signaling pathway_Homo sapiens_hsa040711.20653189
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20063792
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19858003
53ABC transporters_Homo sapiens_hsa020101.18752064
54Peroxisome_Homo sapiens_hsa041461.17447107
55Calcium signaling pathway_Homo sapiens_hsa040201.11042679
56Cocaine addiction_Homo sapiens_hsa050301.10606108
57Staphylococcus aureus infection_Homo sapiens_hsa051501.09619665
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08546687
59ErbB signaling pathway_Homo sapiens_hsa040121.08357473
60mTOR signaling pathway_Homo sapiens_hsa041501.06521821
61Insulin secretion_Homo sapiens_hsa049111.05984193
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04848634
63Circadian rhythm_Homo sapiens_hsa047101.04215242
64Ovarian steroidogenesis_Homo sapiens_hsa049131.04097338
65Phospholipase D signaling pathway_Homo sapiens_hsa040721.03672389
66Butanoate metabolism_Homo sapiens_hsa006501.02161424
67Serotonergic synapse_Homo sapiens_hsa047261.01423722
68Cardiac muscle contraction_Homo sapiens_hsa042601.01092389
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00805516
70Renin secretion_Homo sapiens_hsa049240.99268874
71Tuberculosis_Homo sapiens_hsa051520.99217275
72Regulation of autophagy_Homo sapiens_hsa041400.98648751
73Arachidonic acid metabolism_Homo sapiens_hsa005900.98154257
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98121007
75Protein export_Homo sapiens_hsa030600.97312656
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97269196
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97014864
78Glycerolipid metabolism_Homo sapiens_hsa005610.96581206
79Phagosome_Homo sapiens_hsa041450.95852889
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95757145
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.95609440
82Vibrio cholerae infection_Homo sapiens_hsa051100.94465632
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94423268
84Estrogen signaling pathway_Homo sapiens_hsa049150.94413116
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94328973
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92677657
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90000990
88Taste transduction_Homo sapiens_hsa047420.88810827
89Histidine metabolism_Homo sapiens_hsa003400.88255184
90Basal transcription factors_Homo sapiens_hsa030220.88202402
91Rheumatoid arthritis_Homo sapiens_hsa053230.87630081
92Osteoclast differentiation_Homo sapiens_hsa043800.87206154
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84087848
94Glioma_Homo sapiens_hsa052140.84081672
95Alzheimers disease_Homo sapiens_hsa050100.82811275
96Other glycan degradation_Homo sapiens_hsa005110.82641715
97Fatty acid biosynthesis_Homo sapiens_hsa000610.81752495
98Gap junction_Homo sapiens_hsa045400.81244047
99Pancreatic cancer_Homo sapiens_hsa052120.80313472
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.80287904
101Propanoate metabolism_Homo sapiens_hsa006400.79575720
102VEGF signaling pathway_Homo sapiens_hsa043700.79066242
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77491549
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77353562
105beta-Alanine metabolism_Homo sapiens_hsa004100.76822763
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.75892333
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75404492
108RNA polymerase_Homo sapiens_hsa030200.74605761
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74042660
110Hematopoietic cell lineage_Homo sapiens_hsa046400.73906579
111Mineral absorption_Homo sapiens_hsa049780.73661448
112Dilated cardiomyopathy_Homo sapiens_hsa054140.73398143
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72313328
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71394072
115TNF signaling pathway_Homo sapiens_hsa046680.70553645
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69669818
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69509240
118Platelet activation_Homo sapiens_hsa046110.68322388
119Pertussis_Homo sapiens_hsa051330.67778302
120Huntingtons disease_Homo sapiens_hsa050160.67734787
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67548540
122Salmonella infection_Homo sapiens_hsa051320.66851674
123Endometrial cancer_Homo sapiens_hsa052130.66829261
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.65966277
125Pancreatic secretion_Homo sapiens_hsa049720.65380686
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65013682
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64889556
128Leishmaniasis_Homo sapiens_hsa051400.64822789
129Chemokine signaling pathway_Homo sapiens_hsa040620.64367133
130B cell receptor signaling pathway_Homo sapiens_hsa046620.64166048
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63875921
132MAPK signaling pathway_Homo sapiens_hsa040100.61764312
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61489616
134Endocytosis_Homo sapiens_hsa041440.60942346
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.60915987
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60724580
137Antigen processing and presentation_Homo sapiens_hsa046120.60303204
138Inositol phosphate metabolism_Homo sapiens_hsa005620.59980635
139Non-small cell lung cancer_Homo sapiens_hsa052230.59683788
140Ras signaling pathway_Homo sapiens_hsa040140.56984692
141Insulin resistance_Homo sapiens_hsa049310.56538338
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55947488
143Axon guidance_Homo sapiens_hsa043600.55656168
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54933311
145Malaria_Homo sapiens_hsa051440.54228968
146Influenza A_Homo sapiens_hsa051640.53982086
147Colorectal cancer_Homo sapiens_hsa052100.53752815
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53726470
149Bladder cancer_Homo sapiens_hsa052190.53634156
150NF-kappa B signaling pathway_Homo sapiens_hsa040640.53439918
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.52666552
152Jak-STAT signaling pathway_Homo sapiens_hsa046300.48963391
153Chemical carcinogenesis_Homo sapiens_hsa052040.48519782
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46503031
155Primary bile acid biosynthesis_Homo sapiens_hsa001200.39965594
156Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38943635
157Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36298856
158PPAR signaling pathway_Homo sapiens_hsa033200.33391417

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