ANKDD1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.99596827
2epithelial cilium movement (GO:0003351)9.17050379
3axoneme assembly (GO:0035082)8.11513521
4sensory perception of smell (GO:0007608)7.17397192
5regulation of cilium movement (GO:0003352)6.51264450
6neuronal action potential propagation (GO:0019227)5.29011545
7protein neddylation (GO:0045116)5.28932717
8left/right pattern formation (GO:0060972)4.94302249
9thrombin receptor signaling pathway (GO:0070493)4.86450436
10synaptic vesicle exocytosis (GO:0016079)4.82330200
11neuron cell-cell adhesion (GO:0007158)4.69757782
12neutrophil activation involved in immune response (GO:0002283)4.68256755
13vocalization behavior (GO:0071625)4.57555284
14regulation of synaptic vesicle exocytosis (GO:2000300)4.56645648
15left/right axis specification (GO:0070986)4.56441858
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.54247829
17glutamate secretion (GO:0014047)4.52089726
18vitamin transmembrane transport (GO:0035461)4.48809009
19ventricular system development (GO:0021591)4.41702153
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40763517
21microtubule bundle formation (GO:0001578)4.31910520
22sensory perception of chemical stimulus (GO:0007606)4.28204195
23protein localization to synapse (GO:0035418)4.27792265
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21173497
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16613357
26neuron recognition (GO:0008038)4.09048788
27cilium organization (GO:0044782)4.07157464
28glutamate receptor signaling pathway (GO:0007215)4.00984204
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95748528
30regulation of synaptic vesicle transport (GO:1902803)3.94227376
31behavioral response to cocaine (GO:0048148)3.92241227
32regulation of integrin-mediated signaling pathway (GO:2001044)3.90777046
33axonal fasciculation (GO:0007413)3.89742681
34regulation of glutamate receptor signaling pathway (GO:1900449)3.84493806
35cilium assembly (GO:0042384)3.83670190
36lipoxygenase pathway (GO:0019372)3.81485712
37regulation of microtubule-based movement (GO:0060632)3.81119653
38tolerance induction (GO:0002507)3.80815154
39synaptic vesicle maturation (GO:0016188)3.78684551
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.78620302
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.78357109
42adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.77336324
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.74179249
44negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.73086474
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.70870639
46neuron-neuron synaptic transmission (GO:0007270)3.68527147
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67315531
48regulation of vesicle fusion (GO:0031338)3.67179844
49synaptic transmission, glutamatergic (GO:0035249)3.64760845
50neurotransmitter secretion (GO:0007269)3.61438670
51primary alcohol catabolic process (GO:0034310)3.58338495
52negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.58078016
53cerebellar granule cell differentiation (GO:0021707)3.55342412
54microtubule depolymerization (GO:0007019)3.54262596
55protein localization to cilium (GO:0061512)3.54026885
56presynaptic membrane assembly (GO:0097105)3.53014156
57regulation of germinal center formation (GO:0002634)3.52807230
58intraciliary transport (GO:0042073)3.49296630
59negative regulation of heart rate (GO:0010459)3.45091231
60pyrimidine-containing compound transmembrane transport (GO:0072531)3.44823414
61retinal cone cell development (GO:0046549)3.40857987
62layer formation in cerebral cortex (GO:0021819)3.37302461
63detection of calcium ion (GO:0005513)3.36935471
64regulation of protein kinase A signaling (GO:0010738)3.32552724
65positive regulation of endothelial cell differentiation (GO:0045603)3.31179367
66blood coagulation, intrinsic pathway (GO:0007597)3.28236397
67presynaptic membrane organization (GO:0097090)3.28216161
68activation of protein kinase A activity (GO:0034199)3.26357547
69regulation of platelet activation (GO:0010543)3.25934162
70synaptic vesicle endocytosis (GO:0048488)3.24056903
71regulation of platelet aggregation (GO:0090330)3.23227242
72regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22795759
73diterpenoid biosynthetic process (GO:0016102)3.19994118
74response to amphetamine (GO:0001975)3.19960275
75cellular component assembly involved in morphogenesis (GO:0010927)3.19811279
76cell migration in hindbrain (GO:0021535)3.19648003
77fusion of sperm to egg plasma membrane (GO:0007342)3.19203167
78regulation of interleukin-13 production (GO:0032656)3.17051462
79transmission of nerve impulse (GO:0019226)3.15627437
80low-density lipoprotein particle remodeling (GO:0034374)3.14733880
81response to xenobiotic stimulus (GO:0009410)3.14107572
82positive regulation of synapse maturation (GO:0090129)3.13802983
83regulation of neurotransmitter secretion (GO:0046928)3.13700565
84neurotransmitter transport (GO:0006836)3.11090629
85dendritic spine morphogenesis (GO:0060997)3.10862403
86ethanol metabolic process (GO:0006067)3.10675376
87negative regulation of T-helper cell differentiation (GO:0045623)3.10628097
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10628097
89regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10238440
90purinergic nucleotide receptor signaling pathway (GO:0035590)3.08923645
91regulation of postsynaptic membrane potential (GO:0060078)3.08603102
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07098693
93postsynaptic membrane organization (GO:0001941)3.06225866
94mating behavior (GO:0007617)3.06130525
95retinal rod cell development (GO:0046548)3.05534802
96negative regulation of appetite (GO:0032099)3.02830639
97negative regulation of response to food (GO:0032096)3.02830639
98long-term memory (GO:0007616)3.02655410
99microtubule-based movement (GO:0007018)3.02328340
100regulation of neuronal synaptic plasticity (GO:0048168)3.02293479
101regulation of synaptic transmission, glutamatergic (GO:0051966)3.00293398
102high-density lipoprotein particle remodeling (GO:0034375)2.99171051
103sperm motility (GO:0030317)2.99125055
104G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.98511967
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97988754
106one-carbon compound transport (GO:0019755)2.97743706
107regulation of neurotransmitter transport (GO:0051588)2.97306763
108positive regulation of neurotransmitter transport (GO:0051590)2.96841817
109protein insertion into membrane (GO:0051205)2.96561303
110regulation of cell communication by electrical coupling (GO:0010649)2.95690951
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95609577
112regulation of synapse maturation (GO:0090128)2.94830368
113regulation of synapse structural plasticity (GO:0051823)2.94504531
114cell projection assembly (GO:0030031)2.94199099
115positive regulation of membrane potential (GO:0045838)2.92958297
116regulation of rhodopsin mediated signaling pathway (GO:0022400)2.91551214
117long-term synaptic potentiation (GO:0060291)2.91394485
118regulation of voltage-gated calcium channel activity (GO:1901385)2.90749589
119positive regulation of neurotransmitter secretion (GO:0001956)2.90749451
120dopamine receptor signaling pathway (GO:0007212)2.90669574
121centriole assembly (GO:0098534)2.89762094
122positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89613611
123negative regulation of norepinephrine secretion (GO:0010700)2.88737935
124L-ascorbic acid metabolic process (GO:0019852)2.87693166
125neutrophil activation (GO:0042119)2.85849702
126photoreceptor cell maintenance (GO:0045494)2.85025671
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84617150
128synaptic transmission, dopaminergic (GO:0001963)2.84548084
129cellular response to electrical stimulus (GO:0071257)2.84532613
130membrane depolarization during action potential (GO:0086010)2.84493124
131positive regulation of dendritic spine development (GO:0060999)2.83945331
132locomotory exploration behavior (GO:0035641)2.83723369
133neurotransmitter-gated ion channel clustering (GO:0072578)2.83326376
134regulation of dendritic spine morphogenesis (GO:0061001)2.82972596
135regulation of synaptic plasticity (GO:0048167)2.82920316
136membrane depolarization (GO:0051899)2.82839089
137regulation of dendritic spine development (GO:0060998)2.82279291
138negative regulation of microtubule polymerization (GO:0031115)2.81982296
139response to histamine (GO:0034776)2.81966660
140reverse cholesterol transport (GO:0043691)2.80780730
141positive regulation of action potential (GO:0045760)2.78209868
142membrane hyperpolarization (GO:0060081)2.76784620
143rhodopsin mediated signaling pathway (GO:0016056)2.75866268
144glutathione derivative biosynthetic process (GO:1901687)2.75833129
145glutathione derivative metabolic process (GO:1901685)2.75833129
146adenosine receptor signaling pathway (GO:0001973)2.75534993
147energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74458487
148ATP synthesis coupled proton transport (GO:0015986)2.74458487
149nucleoside diphosphate phosphorylation (GO:0006165)2.74406748
150exploration behavior (GO:0035640)2.74190081
151response to pheromone (GO:0019236)2.72970116
152regulation of neurotransmitter levels (GO:0001505)2.72678581
153regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.72480356
154synaptic transmission (GO:0007268)2.72264209
155cardiolipin metabolic process (GO:0032048)2.71913580
156protein polyglutamylation (GO:0018095)2.71042612
157regulation of macrophage derived foam cell differentiation (GO:0010743)2.70829790
158mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.70767870
159retinol metabolic process (GO:0042572)2.70576741
160mechanosensory behavior (GO:0007638)2.69755491
161negative regulation of thymocyte apoptotic process (GO:0070244)2.69647786
162potassium ion transmembrane transport (GO:0071805)2.69205698
163cellular potassium ion transport (GO:0071804)2.69205698
164negative regulation of platelet activation (GO:0010544)2.66833949
165positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.66777151
166cilium morphogenesis (GO:0060271)2.65326538
167platelet aggregation (GO:0070527)2.65072365
168negative regulation of neurotransmitter transport (GO:0051589)2.64200288
169regulation of megakaryocyte differentiation (GO:0045652)2.64168647
170erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.63709861
171L-phenylalanine catabolic process (GO:0006559)2.63709861
172termination of G-protein coupled receptor signaling pathway (GO:0038032)2.62560625
173regulation of memory T cell differentiation (GO:0043380)2.62355387
174phospholipid homeostasis (GO:0055091)2.61886808
175negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.61621690
176microtubule polymerization or depolymerization (GO:0031109)2.61425362
177androgen biosynthetic process (GO:0006702)2.58658065
178negative regulation of protein localization to cell surface (GO:2000009)2.55453091
179regulation of female receptivity (GO:0045924)2.54638077
180negative regulation of homotypic cell-cell adhesion (GO:0034111)2.54547650
181beta-amyloid metabolic process (GO:0050435)2.52747116
182positive regulation of cAMP-mediated signaling (GO:0043950)2.52648505
183exogenous drug catabolic process (GO:0042738)2.52536800
184long-chain fatty acid biosynthetic process (GO:0042759)2.50988151
185positive regulation of tolerance induction (GO:0002645)2.48296215
186glutathione metabolic process (GO:0006749)2.47221761
187multicellular organism reproduction (GO:0032504)2.46627568
188termination of signal transduction (GO:0023021)2.44815997
189ADP metabolic process (GO:0046031)2.44784556
190regulation of interleukin-5 production (GO:0032674)2.42788081
191sleep (GO:0030431)2.40133698
192leukocyte migration involved in inflammatory response (GO:0002523)2.38977652
193dopamine transport (GO:0015872)2.38488799
194negative regulation of humoral immune response (GO:0002921)2.37233909
195ethanol oxidation (GO:0006069)2.36677828
196axonemal dynein complex assembly (GO:0070286)13.3493642
197cilium or flagellum-dependent cell motility (GO:0001539)13.1210689
198cilium movement (GO:0003341)10.8595042
199epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.7079045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52719889
2GBX2_23144817_ChIP-Seq_PC3_Human3.96275450
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.94374742
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89952401
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86330086
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78852694
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52868518
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52868518
9REST_21632747_ChIP-Seq_MESCs_Mouse2.52078383
10VDR_22108803_ChIP-Seq_LS180_Human2.51580736
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.48231449
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.41671459
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39841873
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35796875
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27345355
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24162712
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22815280
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21416066
19TAF15_26573619_Chip-Seq_HEK293_Human2.17612187
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.17081498
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15860148
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09875392
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.08488084
24SCL_19346495_ChIP-Seq_HPC-7_Human2.06273341
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05986992
26GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.04597295
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.99412336
28DROSHA_22980978_ChIP-Seq_HELA_Human1.98671267
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98426982
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.94983345
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94887819
32GATA1_19941826_ChIP-Seq_K562_Human1.94723590
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93849520
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92034499
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.88716319
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86704067
37IGF1R_20145208_ChIP-Seq_DFB_Human1.84926229
38GATA2_19941826_ChIP-Seq_K562_Human1.84237509
39P300_19829295_ChIP-Seq_ESCs_Human1.83784351
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79297311
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77967162
42ZNF274_21170338_ChIP-Seq_K562_Hela1.77857557
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77083113
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.72382527
45FUS_26573619_Chip-Seq_HEK293_Human1.69677028
46SMAD4_21799915_ChIP-Seq_A2780_Human1.68342370
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67281236
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66037315
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63867136
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62260415
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60064600
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59795994
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59562084
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.59309461
55AR_21572438_ChIP-Seq_LNCaP_Human1.59151909
56STAT1_20625510_ChIP-Seq_HELA_Human1.58950710
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58742178
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55671684
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.55064495
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.54986672
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54411646
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.53858310
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53141723
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51686184
65RNF2_27304074_Chip-Seq_NSC_Mouse1.50470144
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50280861
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48196117
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47834267
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47369496
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46261006
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.45792067
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45762107
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44706514
74GATA4_25053715_ChIP-Seq_YYC3_Human1.44694115
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40699615
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38344278
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37216546
78SMRT_27268052_Chip-Seq_Bcells_Human1.35372724
79AR_20517297_ChIP-Seq_VCAP_Human1.34884723
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34515995
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33309956
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32528464
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.31493200
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28934026
85NANOG_19829295_ChIP-Seq_ESCs_Human1.28536181
86SOX2_19829295_ChIP-Seq_ESCs_Human1.28536181
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26897414
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26743669
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26743669
90STAT3_23295773_ChIP-Seq_U87_Human1.26491048
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26280284
92ER_23166858_ChIP-Seq_MCF-7_Human1.26145467
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25305182
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25068810
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24748078
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24741984
97CDX2_22108803_ChIP-Seq_LS180_Human1.24282223
98HTT_18923047_ChIP-ChIP_STHdh_Human1.24076155
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23461514
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.23043224
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.22445565
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22307899
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.21154642
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.21002365
105AR_25329375_ChIP-Seq_VCAP_Human1.20594051
106ERG_20517297_ChIP-Seq_VCAP_Human1.20512969
107TP63_23658742_ChIP-Seq_EP156T_Human1.20137396
108SPI1_23127762_ChIP-Seq_K562_Human1.18254058
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17935242
110* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17922656
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.16548631
112HNFA_21074721_ChIP-Seq_CACO-2_Human1.15214446
113BCAT_22108803_ChIP-Seq_LS180_Human1.15113372
114GATA1_26923725_Chip-Seq_HPCs_Mouse1.14762313
115TCF4_23295773_ChIP-Seq_U87_Human1.14178731
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.13667964
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13609668
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.13609668
119RUNX2_22187159_ChIP-Seq_PCA_Human1.13574288
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.13109506
121RBPJ_21746931_ChIP-Seq_IB4_Human1.12966512
122CEBPB_22108803_ChIP-Seq_LS180_Human1.12605388
123ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12465140
124ETV1_20927104_ChIP-Seq_GIST48_Human1.12407513
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11986515
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.11702379
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11670703
128CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11573386
129PHF8_20622853_ChIP-Seq_HELA_Human1.10433440
130RUNX_20019798_ChIP-Seq_JUKART_Human1.10175079
131JUN_21703547_ChIP-Seq_K562_Human1.10149986
132GATA3_26560356_Chip-Seq_TH2_Human1.09207919
133RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09124151
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08909414
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08684340
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08684340
137AHR_22903824_ChIP-Seq_MCF-7_Human1.06368889
138STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06328800
139MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06146039
140ESR1_21235772_ChIP-Seq_MCF-7_Human1.05548893
141NFYA_21822215_ChIP-Seq_K562_Human1.05489665
142FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05137077
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04975753
144SALL4_22934838_ChIP-ChIP_CD34+_Human1.04871263
145SOX9_26525672_Chip-Seq_HEART_Mouse1.04589015
146SOX2_20726797_ChIP-Seq_SW620_Human1.04509222
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04337208
148RING1B_27294783_Chip-Seq_NPCs_Mouse1.04270968
149PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03819421
150EWS_26573619_Chip-Seq_HEK293_Human1.03441690
151SMAD3_21741376_ChIP-Seq_ESCs_Human1.03228723
152FOXA1_25552417_ChIP-Seq_VCAP_Human1.02936818
153TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02337089
154* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01736803
155ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01526343
156FOXO3_23340844_ChIP-Seq_DLD1_Human1.01448790
157RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00606923
158AR_19668381_ChIP-Seq_PC3_Human0.99362299
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99314337
160GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99044262
161GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98736992
162NANOG_18555785_Chip-Seq_ESCs_Mouse0.98486948
163CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98267251
164FLI1_27457419_Chip-Seq_LIVER_Mouse0.97133183
165YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95879390
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93395510
167* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93151823
168SMAD4_21741376_ChIP-Seq_EPCs_Human0.91003186
169LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87937255
170WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87934002
171CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87437551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.45307756
2MP0001984_abnormal_olfaction5.09788764
3MP0005083_abnormal_biliary_tract4.79083539
4MP0004859_abnormal_synaptic_plasticity4.70713819
5MP0003880_abnormal_central_pattern4.50903368
6MP0002132_abnormal_respiratory_system3.69342650
7MP0008875_abnormal_xenobiotic_pharmacok3.55721772
8MP0003635_abnormal_synaptic_transmissio3.55145963
9MP0000465_gastrointestinal_hemorrhage3.12744661
10MP0004270_analgesia3.05393936
11MP0009745_abnormal_behavioral_response3.04198510
12MP0003724_increased_susceptibility_to2.91446253
13MP0003011_delayed_dark_adaptation2.86101765
14MP0002064_seizures2.85861935
15MP0002063_abnormal_learning/memory/cond2.81019976
16MP0001968_abnormal_touch/_nociception2.67927568
17MP0009046_muscle_twitch2.64745294
18MP0002272_abnormal_nervous_system2.58626471
19MP0001486_abnormal_startle_reflex2.52846874
20MP0002734_abnormal_mechanical_nocicepti2.48733379
21MP0002572_abnormal_emotion/affect_behav2.43949237
22MP0005365_abnormal_bile_salt2.32562904
23MP0002184_abnormal_innervation2.29316117
24MP0000383_abnormal_hair_follicle2.21586105
25MP0005085_abnormal_gallbladder_physiolo2.21040209
26MP0004043_abnormal_pH_regulation2.18422534
27MP0002736_abnormal_nociception_after2.11230432
28MP0001188_hyperpigmentation2.06446381
29MP0002735_abnormal_chemical_nociception2.05826943
30MP0006276_abnormal_autonomic_nervous2.03448336
31MP0002067_abnormal_sensory_capabilities1.99866668
32MP0001501_abnormal_sleep_pattern1.97142959
33MP0006072_abnormal_retinal_apoptosis1.94423873
34MP0005551_abnormal_eye_electrophysiolog1.93921032
35MP0005084_abnormal_gallbladder_morpholo1.93311097
36MP0000778_abnormal_nervous_system1.91722641
37MP0005646_abnormal_pituitary_gland1.86862467
38MP0001835_abnormal_antigen_presentation1.86323074
39MP0001905_abnormal_dopamine_level1.85225268
40MP0003195_calcinosis1.83871533
41MP0000230_abnormal_systemic_arterial1.83696501
42MP0005423_abnormal_somatic_nervous1.76133202
43MP0005410_abnormal_fertilization1.75502256
44MP0010678_abnormal_skin_adnexa1.71204565
45MP0010155_abnormal_intestine_physiology1.70499696
46MP0004145_abnormal_muscle_electrophysio1.68911856
47MP0001970_abnormal_pain_threshold1.68877625
48MP0003303_peritoneal_inflammation1.67425963
49MP0001765_abnormal_ion_homeostasis1.66249913
50MP0001440_abnormal_grooming_behavior1.65082667
51MP0002876_abnormal_thyroid_physiology1.63941211
52MP0002557_abnormal_social/conspecific_i1.62735071
53MP0003656_abnormal_erythrocyte_physiolo1.61727507
54MP0002733_abnormal_thermal_nociception1.61613380
55MP0008872_abnormal_physiological_respon1.60540237
56MP0000955_abnormal_spinal_cord1.57010689
57MP0002882_abnormal_neuron_morphology1.56148489
58MP0003329_amyloid_beta_deposits1.53793904
59MP0004811_abnormal_neuron_physiology1.53775347
60MP0004019_abnormal_vitamin_homeostasis1.53112253
61MP0003122_maternal_imprinting1.51732431
62MP0001529_abnormal_vocalization1.51596537
63MP0003787_abnormal_imprinting1.47857206
64MP0005386_behavior/neurological_phenoty1.47093103
65MP0004924_abnormal_behavior1.47093103
66MP0010329_abnormal_lipoprotein_level1.46890960
67MP0002822_catalepsy1.40013595
68MP0003718_maternal_effect1.36827979
69MP0001879_abnormal_lymphatic_vessel1.36424235
70MP0002909_abnormal_adrenal_gland1.35902178
71MP0002638_abnormal_pupillary_reflex1.35348051
72MP0003638_abnormal_response/metabolism_1.33753195
73MP0002752_abnormal_somatic_nervous1.32953720
74MP0003828_pulmonary_edema1.32849883
75MP0002066_abnormal_motor_capabilities/c1.32417300
76MP0004215_abnormal_myocardial_fiber1.30111872
77MP0000343_altered_response_to1.29219310
78MP0002229_neurodegeneration1.26710785
79MP0000751_myopathy1.26685290
80MP0004142_abnormal_muscle_tone1.26097011
81MP0004484_altered_response_of1.24618670
82MP0003866_abnormal_defecation1.23826828
83MP0002837_dystrophic_cardiac_calcinosis1.22485530
84MP0002148_abnormal_hypersensitivity_rea1.21951624
85MP0002234_abnormal_pharynx_morphology1.19268260
86MP0008569_lethality_at_weaning1.18000873
87MP0005167_abnormal_blood-brain_barrier1.17514807
88MP0002152_abnormal_brain_morphology1.16141656
89MP0005645_abnormal_hypothalamus_physiol1.15007065
90MP0006036_abnormal_mitochondrial_physio1.14684115
91MP0005000_abnormal_immune_tolerance1.12423903
92MP0009780_abnormal_chondrocyte_physiolo1.10623301
93MP0008775_abnormal_heart_ventricle1.09358901
94MP0001663_abnormal_digestive_system1.09193445
95MP0005409_darkened_coat_color1.08913631
96MP0009643_abnormal_urine_homeostasis1.08583056
97MP0004085_abnormal_heartbeat1.07991987
98MP0002277_abnormal_respiratory_mucosa1.07317827
99MP0003252_abnormal_bile_duct1.06347693
100MP0005394_taste/olfaction_phenotype1.06233333
101MP0005499_abnormal_olfactory_system1.06233333
102MP0009763_increased_sensitivity_to1.06171616
103MP0004133_heterotaxia1.05818579
104MP0003879_abnormal_hair_cell1.04956327
105MP0004742_abnormal_vestibular_system1.03805282
106MP0009765_abnormal_xenobiotic_induced0.99975837
107MP0005636_abnormal_mineral_homeostasis0.99795019
108MP0002653_abnormal_ependyma_morphology0.97244284
109MP0004036_abnormal_muscle_relaxation0.97028101
110MP0004858_abnormal_nervous_system0.94662157
111MP0005220_abnormal_exocrine_pancreas0.93812278
112MP0002136_abnormal_kidney_physiology0.93702975
113MP0001963_abnormal_hearing_physiology0.93429755
114MP0002102_abnormal_ear_morphology0.93242037
115MP0000249_abnormal_blood_vessel0.92899775
116MP0009642_abnormal_blood_homeostasis0.90980027
117MP0001545_abnormal_hematopoietic_system0.89808169
118MP0005397_hematopoietic_system_phenotyp0.89808169
119MP0001485_abnormal_pinna_reflex0.89720581
120MP0001664_abnormal_digestion0.89627910
121MP0003631_nervous_system_phenotype0.89627748
122MP0004883_abnormal_blood_vessel0.89251116
123MP0005165_increased_susceptibility_to0.88398023
124MP0001533_abnormal_skeleton_physiology0.87672177
125MP0010386_abnormal_urinary_bladder0.87651783
126MP0006292_abnormal_olfactory_placode0.87322497
127MP0003633_abnormal_nervous_system0.87012765
128MP0005253_abnormal_eye_physiology0.86861498
129MP0004947_skin_inflammation0.86293401
130MP0008789_abnormal_olfactory_epithelium0.85973928
131MP0005395_other_phenotype0.85062619
132MP0002723_abnormal_immune_serum0.84773422
133MP0002127_abnormal_cardiovascular_syste0.84673097
134MP0001845_abnormal_inflammatory_respons0.84528041
135MP0001756_abnormal_urination0.83802186
136MP0003136_yellow_coat_color0.83650213
137MP0001800_abnormal_humoral_immune0.82889898
138MP0003632_abnormal_nervous_system0.82494725
139MP0002452_abnormal_antigen_presenting0.81924453
140MP0002118_abnormal_lipid_homeostasis0.81738818
141MP0002405_respiratory_system_inflammati0.81359729
142MP0005058_abnormal_lysosome_morphology0.80426077
143MP0008004_abnormal_stomach_pH0.79942801
144MP0001177_atelectasis0.79765136
145MP0000631_abnormal_neuroendocrine_gland0.79685688
146MP0003634_abnormal_glial_cell0.79613914
147MP0004147_increased_porphyrin_level0.79148109
148MP0005195_abnormal_posterior_eye0.77499622
149MP0005310_abnormal_salivary_gland0.77473239
150MP0005164_abnormal_response_to0.77106297
151MP0004130_abnormal_muscle_cell0.76912748
152MP0002090_abnormal_vision0.76614301
153MP0003566_abnormal_cell_adhesion0.75447448
154MP0005671_abnormal_response_to0.74763425
155MP0003646_muscle_fatigue0.74478025
156MP0003121_genomic_imprinting0.74036259
157MP0009379_abnormal_foot_pigmentation0.73372392
158MP0001502_abnormal_circadian_rhythm0.73092726
159MP0003698_abnormal_male_reproductive0.72884750
160MP0001929_abnormal_gametogenesis0.71961071
161MP0003861_abnormal_nervous_system0.71736639
162MP0010234_abnormal_vibrissa_follicle0.70997031
163MP0008877_abnormal_DNA_methylation0.70705146
164MP0000026_abnormal_inner_ear0.70345893
165MP0002751_abnormal_autonomic_nervous0.69405545
166MP0003123_paternal_imprinting0.69218280
167MP0008874_decreased_physiological_sensi0.68923074
168MP0002069_abnormal_eating/drinking_beha0.68838395
169MP0004084_abnormal_cardiac_muscle0.68478038
170MP0002332_abnormal_exercise_endurance0.68203497
171MP0001851_eye_inflammation0.67918581
172MP0003137_abnormal_impulse_conducting0.67826688
173MP0003436_decreased_susceptibility_to0.67690726
174MP0001790_abnormal_immune_system0.65582388
175MP0005387_immune_system_phenotype0.65582388
176MP0009764_decreased_sensitivity_to0.64680680
177MP0005623_abnormal_meninges_morphology0.64553988
178MP0002139_abnormal_hepatobiliary_system0.63803837
179MP0002160_abnormal_reproductive_system0.63561691
180MP0005025_abnormal_response_to0.62708084
181MP0002419_abnormal_innate_immunity0.61898967
182MP0002398_abnormal_bone_marrow0.60714800
183MP0002168_other_aberrant_phenotype0.58967393

Predicted human phenotypes

RankGene SetZ-score
1Bronchiectasis (HP:0002110)6.09018864
2Focal motor seizures (HP:0011153)5.82448371
3Nasal polyposis (HP:0100582)5.39504858
4Atonic seizures (HP:0010819)5.08636928
5Prolonged bleeding time (HP:0003010)4.80372029
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.53718017
7Epileptic encephalopathy (HP:0200134)4.49750221
8Abnormality of the nasal mucosa (HP:0000433)4.48144660
9Febrile seizures (HP:0002373)4.35157970
10Focal seizures (HP:0007359)4.20253986
11Limb dystonia (HP:0002451)4.13588320
12Menorrhagia (HP:0000132)4.00181495
13Absence seizures (HP:0002121)3.89827541
14Recurrent sinusitis (HP:0011108)3.87144401
15Myokymia (HP:0002411)3.85273021
16Bronchitis (HP:0012387)3.80095292
17Infertility (HP:0000789)3.79772875
18Purpura (HP:0000979)3.68282729
19Increased mean platelet volume (HP:0011877)3.68016246
20Chronic sinusitis (HP:0011109)3.67770012
21Male infertility (HP:0003251)3.65372075
22Petechiae (HP:0000967)3.57478233
23Retinal dysplasia (HP:0007973)3.38991811
24Abnormal platelet volume (HP:0011876)3.38551348
25Dialeptic seizures (HP:0011146)3.36047291
26Hyperventilation (HP:0002883)3.33493956
27Rhinitis (HP:0012384)3.25632061
28Visual hallucinations (HP:0002367)3.15774930
29Abnormal respiratory motile cilium physiology (HP:0012261)3.05074694
30Muscle hypertrophy of the lower extremities (HP:0008968)3.02885700
31Epistaxis (HP:0000421)3.02541865
32Chronic otitis media (HP:0000389)3.00681269
33Abnormality of macular pigmentation (HP:0008002)2.89712760
34Insidious onset (HP:0003587)2.87527120
35Termporal pattern (HP:0011008)2.87527120
36Bony spicule pigmentary retinopathy (HP:0007737)2.86254534
37Recurrent otitis media (HP:0000403)2.84089354
38Broad-based gait (HP:0002136)2.83265248
39Acute necrotizing encephalopathy (HP:0006965)2.80354394
40Progressive cerebellar ataxia (HP:0002073)2.77920317
41Hyperlipoproteinemia (HP:0010980)2.77657826
42Hyperactive renin-angiotensin system (HP:0000841)2.72232329
43Generalized tonic-clonic seizures (HP:0002069)2.69809099
44Gait imbalance (HP:0002141)2.69481137
45Hyperthyroidism (HP:0000836)2.67600970
46Chronic hepatic failure (HP:0100626)2.64510086
47Pheochromocytoma (HP:0002666)2.63320561
48Tubulointerstitial nephritis (HP:0001970)2.62820285
49Amblyopia (HP:0000646)2.57117816
50Pancreatic fibrosis (HP:0100732)2.56890670
51Abnormal mitochondria in muscle tissue (HP:0008316)2.53225386
52Progressive macrocephaly (HP:0004481)2.52952225
53True hermaphroditism (HP:0010459)2.52801973
54Progressive inability to walk (HP:0002505)2.48356269
55Chronic bronchitis (HP:0004469)2.48225839
56Neuroendocrine neoplasm (HP:0100634)2.48105398
57Pancreatic cysts (HP:0001737)2.43421004
58Syncope (HP:0001279)2.41787260
59Gingival bleeding (HP:0000225)2.39351114
60Gaze-evoked nystagmus (HP:0000640)2.38162019
61Acanthocytosis (HP:0001927)2.37766506
62Nephronophthisis (HP:0000090)2.37387015
63Anxiety (HP:0000739)2.35471906
64Congenital primary aphakia (HP:0007707)2.34506641
65Occipital encephalocele (HP:0002085)2.32125306
66Agitation (HP:0000713)2.30450205
67Depression (HP:0000716)2.29961440
68Decreased circulating renin level (HP:0003351)2.28434224
69Abnormal ciliary motility (HP:0012262)2.27780404
70Abnormality of the corticospinal tract (HP:0002492)2.26502956
71Split foot (HP:0001839)2.26097608
72Narrow nasal bridge (HP:0000446)2.25900733
73Epileptiform EEG discharges (HP:0011182)2.25541277
74Decreased central vision (HP:0007663)2.25342635
75Drooling (HP:0002307)2.24500198
76Excessive salivation (HP:0003781)2.24500198
77Delusions (HP:0000746)2.23483105
78Central scotoma (HP:0000603)2.23395440
79Truncal ataxia (HP:0002078)2.21262478
80Mutism (HP:0002300)2.19600667
81Absent speech (HP:0001344)2.19087826
82Abnormal rod and cone electroretinograms (HP:0008323)2.16658628
83Sensory axonal neuropathy (HP:0003390)2.15141463
84Failure to thrive in infancy (HP:0001531)2.14748372
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.14363046
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14363046
87Optic disc pallor (HP:0000543)2.14213074
88Dysmetria (HP:0001310)2.13293705
89Medial flaring of the eyebrow (HP:0010747)2.12582068
90Inability to walk (HP:0002540)2.12421887
91Nephrogenic diabetes insipidus (HP:0009806)2.11889406
92Mitochondrial inheritance (HP:0001427)2.11191640
93Abnormal respiratory motile cilium morphology (HP:0005938)2.11175392
94Abnormal respiratory epithelium morphology (HP:0012253)2.11175392
95Congenital stationary night blindness (HP:0007642)2.09567024
96Abnormal hair whorl (HP:0010721)2.09257133
97EEG with generalized epileptiform discharges (HP:0011198)2.09143677
98Impaired platelet aggregation (HP:0003540)2.08232437
99Abnormal platelet function (HP:0011869)2.08232437
100Dyschromatopsia (HP:0007641)2.04127946
101Poikilocytosis (HP:0004447)2.02694575
102Specific learning disability (HP:0001328)2.01978580
103Stereotypic behavior (HP:0000733)2.01858653
104Cystic liver disease (HP:0006706)2.01388225
105Recurrent bronchitis (HP:0002837)2.01080109
106Acute encephalopathy (HP:0006846)1.99556792
107Cerebral hypomyelination (HP:0006808)1.98896466
108Ventricular fibrillation (HP:0001663)1.97465040
109Abnormality of the renal medulla (HP:0100957)1.97068044
110Protruding tongue (HP:0010808)1.96291874
111Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96252857
112Dysdiadochokinesis (HP:0002075)1.96226598
113Methylmalonic acidemia (HP:0002912)1.94367788
114Cerebral inclusion bodies (HP:0100314)1.93647873
115Hypsarrhythmia (HP:0002521)1.92495170
116Inappropriate behavior (HP:0000719)1.91441355
117Genital tract atresia (HP:0001827)1.91148155
118Choroideremia (HP:0001139)1.90064826
119Calf muscle hypertrophy (HP:0008981)1.90025449
120Insulin-resistant diabetes mellitus (HP:0000831)1.87939926
121Focal dystonia (HP:0004373)1.87721862
122Vaginal atresia (HP:0000148)1.87001557
123Hypoventilation (HP:0002791)1.86222265
124Absent/shortened dynein arms (HP:0200106)1.85570799
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.85570799
126Neurofibrillary tangles (HP:0002185)1.85415291
127Postural instability (HP:0002172)1.83685580
128Dysphonia (HP:0001618)1.83163717
129Abnormal eating behavior (HP:0100738)1.81831807
130Atelectasis (HP:0100750)1.81536701
131Polyphagia (HP:0002591)1.81169796
132Torticollis (HP:0000473)1.81023229
133Progressive external ophthalmoplegia (HP:0000590)1.80233197
134Abnormality of midbrain morphology (HP:0002418)1.80219309
135Molar tooth sign on MRI (HP:0002419)1.80219309
136Abnormal pupillary function (HP:0007686)1.79863459
137Palpitations (HP:0001962)1.78905356
138Action tremor (HP:0002345)1.77283345
139Male pseudohermaphroditism (HP:0000037)1.71125836
140Abnormality of the renal cortex (HP:0011035)1.68184956
141Congenital hepatic fibrosis (HP:0002612)1.67406973
142Joint swelling (HP:0001386)1.65759853
143Abnormality of renin-angiotensin system (HP:0000847)1.63754865
144Postaxial foot polydactyly (HP:0001830)1.59545854
145Nephropathy (HP:0000112)1.58443244
146Renal salt wasting (HP:0000127)1.57343925
147Hyperaldosteronism (HP:0000859)1.57174510
148Hyperkalemia (HP:0002153)1.55607895
149Hypophosphatemic rickets (HP:0004912)1.50435447
150Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.49622061
151Hypokalemic alkalosis (HP:0001949)1.47566214
152Median cleft lip (HP:0000161)1.45826075
153Tubular atrophy (HP:0000092)1.44400228
154Paralysis (HP:0003470)1.44197299
155Xanthomatosis (HP:0000991)1.38698617
156Cone-rod dystrophy (HP:0000548)1.38292213
157Tubulointerstitial abnormality (HP:0001969)1.38246288
158Abnormality of transition element cation homeostasis (HP:0011030)1.38213126
159Stomatitis (HP:0010280)1.36277160
160Pancreatic islet-cell hyperplasia (HP:0004510)1.34130548
161Polydipsia (HP:0001959)1.33404784
162Abnormal drinking behavior (HP:0030082)1.33404784
163Oculomotor apraxia (HP:0000657)1.32492793
164Azoospermia (HP:0000027)1.31475711
165Abnormality of chloride homeostasis (HP:0011422)1.31132045
166Anencephaly (HP:0002323)1.30513304
167Conjunctival telangiectasia (HP:0000524)1.29907100
168Abnormal spermatogenesis (HP:0008669)1.29714889
169Abnormality of iron homeostasis (HP:0011031)1.28713304
170Furrowed tongue (HP:0000221)1.26973403
171Vascular calcification (HP:0004934)1.25953125
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.24259770
173Spontaneous hematomas (HP:0007420)1.24005234
174Bell-shaped thorax (HP:0001591)1.21131219
175Stage 5 chronic kidney disease (HP:0003774)1.19472864
176Portal hypertension (HP:0001409)1.19428183
177Renal cortical cysts (HP:0000803)1.18255820
178Abnormality of the heme biosynthetic pathway (HP:0010472)1.17740575
179Postaxial hand polydactyly (HP:0001162)1.17174172
180Bruising susceptibility (HP:0000978)1.16701526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST47.03702020
2MAPK154.62474208
3CASK4.11397278
4TAOK33.84815404
5MAP3K43.29834512
6MAP3K93.26413291
7EPHA43.14685678
8NTRK33.02912579
9MAP2K72.88728826
10ACVR1B2.61387803
11MAPKAPK32.59465535
12TEC2.39406914
13MYLK2.39175175
14MARK12.37114141
15MAPK132.30742282
16MINK12.28478361
17BMX2.21905017
18PLK22.07087228
19STK392.06619320
20GRK62.03933631
21DAPK22.00351636
22ARAF1.84662604
23FRK1.83012645
24BTK1.78971296
25EIF2AK11.77902644
26CDK191.74150621
27WNK41.67587681
28PNCK1.65529126
29STK161.62751039
30MAP2K41.62030736
31KSR11.60294849
32PRPF4B1.58422531
33OXSR11.56750255
34GRK51.46423566
35FES1.45413191
36CAMK2B1.45059743
37MAP3K121.43847287
38PAK61.42587421
39PAK31.42068631
40RIPK41.40567170
41IKBKB1.39390977
42CSF1R1.38939471
43NTRK21.31494445
44PIK3CG1.31484951
45TRPM71.31070538
46PRKCG1.28976130
47DYRK1A1.27291713
48CAMK2A1.26154983
49CAMK2D1.23836267
50ERBB31.22457590
51NME11.21693170
52KSR21.21142653
53CDK51.20422200
54EPHA21.20093453
55DAPK11.15018973
56MAP3K131.14831144
57SYK1.14629034
58ZAP701.13955867
59ILK1.11449812
60GRK11.10254797
61PHKG11.09834519
62PHKG21.09834519
63TBK11.06709371
64CDK141.06446805
65TNIK1.06273486
66MAPKAPK51.05581775
67CAMKK21.04682954
68WNK11.04497813
69MAP2K21.00515978
70CCNB10.99332548
71STK30.98179975
72CDK180.98076329
73STK380.97929739
74AKT30.97065465
75IKBKE0.97014095
76NTRK10.95349629
77TLK10.93373785
78CDK150.93236437
79CSNK1G20.93230137
80MUSK0.90370007
81SGK4940.90064310
82SGK2230.90064310
83ERBB20.88460967
84CAMKK10.87575597
85MAP3K20.86309373
86FER0.84566987
87NEK90.83204086
88ITK0.83139778
89STK38L0.82691824
90LYN0.81273214
91CDK11A0.81164545
92CSNK1G30.79735779
93CAMK2G0.79484646
94LMTK20.79065750
95PTK2B0.78577116
96IRAK10.77963440
97TNK20.77089300
98TXK0.76006627
99RAF10.74071744
100PIM20.73724564
101MAP3K10.73562557
102MAP4K20.73057478
103PRKCE0.72494699
104LATS20.69286971
105ROCK20.65801677
106SIK20.65724276
107HCK0.65174030
108CSK0.65122051
109PAK10.65093108
110ADRBK20.64259398
111TYRO30.62848355
112PRKD10.61825488
113UHMK10.60436563
114ERBB40.59706421
115STK110.59179742
116MAPK120.58657644
117PRKD30.58473836
118BRAF0.58414835
119EIF2AK30.54925726
120MAPK100.54656077
121NUAK10.54234420
122STK100.53575248
123BMPR1B0.52598463
124BMPR20.51882795
125SGK20.51360444
126PRKCH0.50632259
127PDPK10.50283437
128FGR0.49552411
129PKN10.47845343
130MKNK20.47147871
131MAP2K10.46650758
132ALK0.46414543
133PRKCZ0.45990886
134FLT30.45768081
135BCR0.45559278
136CAMK10.44992443
137BLK0.44789974
138PRKCQ0.43808640
139WNK30.42768538
140MAP3K60.42514034
141TAF10.42140815
142PRKCI0.41989331
143DAPK30.41961255
144ADRBK10.41629633
145PRKCD0.41509278
146ABL10.40599534
147CSNK1G10.40224500
148IGF1R0.39657086
149ZAK0.39002797
150STK240.37831474
151TESK20.37437378
152PRKG10.37239703
153PDK10.37149479
154PINK10.36755130
155HIPK20.36750325
156PIM10.36687472
157SGK30.34717726
158STK40.31917501
159PRKCA0.31692468
160MATK0.31437679
161EPHA30.30142489
162MAP3K30.29844866
163MAP3K70.29180445

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.68081909
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.37264172
3Nicotine addiction_Homo sapiens_hsa050333.29038375
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.12238258
5Phototransduction_Homo sapiens_hsa047443.03599512
6Chemical carcinogenesis_Homo sapiens_hsa052042.96182877
7Synaptic vesicle cycle_Homo sapiens_hsa047212.95507298
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72421864
9Circadian entrainment_Homo sapiens_hsa047132.52671285
10Morphine addiction_Homo sapiens_hsa050322.49368385
11GABAergic synapse_Homo sapiens_hsa047272.48028453
12Arachidonic acid metabolism_Homo sapiens_hsa005902.46004325
13Amphetamine addiction_Homo sapiens_hsa050312.41038412
14Long-term potentiation_Homo sapiens_hsa047202.37183528
15Nitrogen metabolism_Homo sapiens_hsa009102.34182066
16Glutamatergic synapse_Homo sapiens_hsa047242.32771195
17Dopaminergic synapse_Homo sapiens_hsa047282.28769051
18Oxidative phosphorylation_Homo sapiens_hsa001902.27447178
19Linoleic acid metabolism_Homo sapiens_hsa005912.20300117
20Retinol metabolism_Homo sapiens_hsa008302.15844653
21Parkinsons disease_Homo sapiens_hsa050122.14559877
22beta-Alanine metabolism_Homo sapiens_hsa004102.12322786
23Steroid hormone biosynthesis_Homo sapiens_hsa001402.02184251
24Histidine metabolism_Homo sapiens_hsa003402.00439618
25Glutathione metabolism_Homo sapiens_hsa004801.99701263
26Salivary secretion_Homo sapiens_hsa049701.97878035
27Tyrosine metabolism_Homo sapiens_hsa003501.96873102
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89086745
29Cardiac muscle contraction_Homo sapiens_hsa042601.87829152
30Alzheimers disease_Homo sapiens_hsa050101.87440303
31Serotonergic synapse_Homo sapiens_hsa047261.82605558
32Insulin secretion_Homo sapiens_hsa049111.81505819
33Gastric acid secretion_Homo sapiens_hsa049711.80979395
34Taste transduction_Homo sapiens_hsa047421.79982655
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.78417068
36Renin secretion_Homo sapiens_hsa049241.77095579
37Cocaine addiction_Homo sapiens_hsa050301.75216147
38Hematopoietic cell lineage_Homo sapiens_hsa046401.74202115
39Long-term depression_Homo sapiens_hsa047301.72499369
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72192153
41Cholinergic synapse_Homo sapiens_hsa047251.71372582
42Collecting duct acid secretion_Homo sapiens_hsa049661.71082468
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.67896816
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67644521
45ABC transporters_Homo sapiens_hsa020101.66704144
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65741675
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61085106
48Vibrio cholerae infection_Homo sapiens_hsa051101.52539348
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50700156
50Oxytocin signaling pathway_Homo sapiens_hsa049211.49720967
51Calcium signaling pathway_Homo sapiens_hsa040201.48827025
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47221329
53Gap junction_Homo sapiens_hsa045401.44749727
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44227832
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41020200
56Glycerolipid metabolism_Homo sapiens_hsa005611.39411835
57GnRH signaling pathway_Homo sapiens_hsa049121.36777401
58Caffeine metabolism_Homo sapiens_hsa002321.36369316
59Huntingtons disease_Homo sapiens_hsa050161.30553217
60cAMP signaling pathway_Homo sapiens_hsa040241.24862089
61Phenylalanine metabolism_Homo sapiens_hsa003601.19864468
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19437983
63Sulfur metabolism_Homo sapiens_hsa009201.17319269
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16583624
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11783763
66ECM-receptor interaction_Homo sapiens_hsa045121.07308346
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05033109
68Axon guidance_Homo sapiens_hsa043601.02372253
69Estrogen signaling pathway_Homo sapiens_hsa049151.01519634
70Melanogenesis_Homo sapiens_hsa049161.01330455
71Starch and sucrose metabolism_Homo sapiens_hsa005000.96449222
72Oocyte meiosis_Homo sapiens_hsa041140.94930016
73Dilated cardiomyopathy_Homo sapiens_hsa054140.90687646
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88898648
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.88766727
76Chemokine signaling pathway_Homo sapiens_hsa040620.87114074
77Peroxisome_Homo sapiens_hsa041460.84567771
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84280887
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84208709
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83666049
81ErbB signaling pathway_Homo sapiens_hsa040120.82357515
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.81076450
83PPAR signaling pathway_Homo sapiens_hsa033200.80654468
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79863986
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.78757919
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78204666
87Thyroid hormone synthesis_Homo sapiens_hsa049180.75027684
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.73692547
89Dorso-ventral axis formation_Homo sapiens_hsa043200.72538587
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71201132
91Alcoholism_Homo sapiens_hsa050340.70646662
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70493163
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68692008
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66909757
95Pancreatic secretion_Homo sapiens_hsa049720.66880651
96Glioma_Homo sapiens_hsa052140.66719229
97Ras signaling pathway_Homo sapiens_hsa040140.63656443
98Fat digestion and absorption_Homo sapiens_hsa049750.62170164
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.62041851
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60933236
101Systemic lupus erythematosus_Homo sapiens_hsa053220.59277291
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59203869
103Inositol phosphate metabolism_Homo sapiens_hsa005620.58909084
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58512853
105MAPK signaling pathway_Homo sapiens_hsa040100.58065129
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.56391331
107Type II diabetes mellitus_Homo sapiens_hsa049300.54688194
108Tryptophan metabolism_Homo sapiens_hsa003800.53879134
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53474271
110Complement and coagulation cascades_Homo sapiens_hsa046100.53118494
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.51652179
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51386408
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50625729
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50205538
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.46914754
116Fatty acid degradation_Homo sapiens_hsa000710.46030068
117Choline metabolism in cancer_Homo sapiens_hsa052310.45816852
118Glucagon signaling pathway_Homo sapiens_hsa049220.45460976
119Arginine and proline metabolism_Homo sapiens_hsa003300.45093298
120Rap1 signaling pathway_Homo sapiens_hsa040150.44905152
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44877690
122Fatty acid elongation_Homo sapiens_hsa000620.43808944
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43586550
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.43474342
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43438277
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41676584
127Regulation of autophagy_Homo sapiens_hsa041400.41542048
128Bile secretion_Homo sapiens_hsa049760.40925235
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40207417
130Asthma_Homo sapiens_hsa053100.39438713
131Renal cell carcinoma_Homo sapiens_hsa052110.38935592
132Ovarian steroidogenesis_Homo sapiens_hsa049130.38513366
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37969860
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36711858
135Graft-versus-host disease_Homo sapiens_hsa053320.34346474
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34123607
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33433332
138Vitamin digestion and absorption_Homo sapiens_hsa049770.31772780
139Wnt signaling pathway_Homo sapiens_hsa043100.31695007
140Metabolic pathways_Homo sapiens_hsa011000.30915446
141Sphingolipid metabolism_Homo sapiens_hsa006000.30580221
142Legionellosis_Homo sapiens_hsa051340.30014447
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29864165
144VEGF signaling pathway_Homo sapiens_hsa043700.29766904
145Circadian rhythm_Homo sapiens_hsa047100.29355659
146T cell receptor signaling pathway_Homo sapiens_hsa046600.28115007
147Tight junction_Homo sapiens_hsa045300.28026182
148TNF signaling pathway_Homo sapiens_hsa046680.27957860
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27418966
150Autoimmune thyroid disease_Homo sapiens_hsa053200.26597768
151Ether lipid metabolism_Homo sapiens_hsa005650.25113753
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24916927
153Endocytosis_Homo sapiens_hsa041440.24024674
154Melanoma_Homo sapiens_hsa052180.23956296
155Platelet activation_Homo sapiens_hsa046110.22355389
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20619321
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18677537
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18492443
159Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18336085
160Purine metabolism_Homo sapiens_hsa002300.17458409
161Neurotrophin signaling pathway_Homo sapiens_hsa047220.17005131
162Insulin signaling pathway_Homo sapiens_hsa049100.14492139
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13911023
164Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13892310
165Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12487713

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