ANKEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.78251289
2acrosome assembly (GO:0001675)9.76633899
3multicellular organism reproduction (GO:0032504)9.73011639
4sperm-egg recognition (GO:0035036)9.55913092
5axonemal dynein complex assembly (GO:0070286)9.34124762
6plasma membrane fusion (GO:0045026)9.09571795
7epithelial cilium movement (GO:0003351)9.01683602
8binding of sperm to zona pellucida (GO:0007339)8.54197207
9cell-cell recognition (GO:0009988)8.53592654
10motile cilium assembly (GO:0044458)8.38893399
11reproduction (GO:0000003)8.24093885
12spermatid development (GO:0007286)8.09628130
13cilium movement (GO:0003341)7.62112545
14regulation of cilium movement (GO:0003352)7.49229485
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.00609672
16sperm capacitation (GO:0048240)6.72786377
17single fertilization (GO:0007338)6.65787363
18piRNA metabolic process (GO:0034587)6.23928620
19male meiosis (GO:0007140)6.21167332
20synaptonemal complex organization (GO:0070193)5.94949854
21organic cation transport (GO:0015695)5.75229344
22synaptonemal complex assembly (GO:0007130)5.71289915
23low-density lipoprotein particle clearance (GO:0034383)5.64068989
24fertilization (GO:0009566)5.48423145
25spermatogenesis (GO:0007283)5.41646584
26male gamete generation (GO:0048232)5.39396621
27negative regulation of inclusion body assembly (GO:0090084)5.37472025
28regulation of sequestering of triglyceride (GO:0010889)5.23254616
29microtubule depolymerization (GO:0007019)5.18275781
30gamete generation (GO:0007276)4.95189252
31carnitine transmembrane transport (GO:1902603)4.90402643
32carnitine transport (GO:0015879)4.79857299
33amino-acid betaine transport (GO:0015838)4.79857299
34ventricular system development (GO:0021591)4.65396404
35calcium ion-dependent exocytosis (GO:0017156)4.63268302
36triglyceride catabolic process (GO:0019433)4.60465052
37cellular process involved in reproduction in multicellular organism (GO:0022412)4.56575921
38germ cell development (GO:0007281)4.43253415
39male meiosis I (GO:0007141)4.32132262
40alditol metabolic process (GO:0019400)4.31678976
41brown fat cell differentiation (GO:0050873)4.27456053
42seminiferous tubule development (GO:0072520)4.26407646
43glycerol metabolic process (GO:0006071)4.22648219
44regulation of inclusion body assembly (GO:0090083)4.21027028
45regulation of microtubule-based movement (GO:0060632)4.14623748
46cell recognition (GO:0008037)4.13401439
47cellular ketone body metabolic process (GO:0046950)4.13005775
48microtubule severing (GO:0051013)4.12729181
49glycerol ether metabolic process (GO:0006662)4.10844086
50DNA methylation involved in gamete generation (GO:0043046)4.06589780
51acylglycerol catabolic process (GO:0046464)4.06304640
52neutral lipid catabolic process (GO:0046461)4.06304640
53white fat cell differentiation (GO:0050872)3.99534080
54chromosome organization involved in meiosis (GO:0070192)3.99255941
55multicellular organismal reproductive process (GO:0048609)3.96960819
56fatty acid transmembrane transport (GO:1902001)3.89312791
57carnitine shuttle (GO:0006853)3.85561071
58spermatid nucleus differentiation (GO:0007289)3.84762621
59indole-containing compound catabolic process (GO:0042436)3.81460641
60indolalkylamine catabolic process (GO:0046218)3.81460641
61tryptophan catabolic process (GO:0006569)3.81460641
62ether metabolic process (GO:0018904)3.77211920
63signal peptide processing (GO:0006465)3.74135966
64UDP-N-acetylglucosamine metabolic process (GO:0006047)3.73281532
65ketone body metabolic process (GO:1902224)3.72118700
66left/right pattern formation (GO:0060972)3.69663168
67genitalia morphogenesis (GO:0035112)3.64722073
68triglyceride biosynthetic process (GO:0019432)3.59409152
69lipid particle organization (GO:0034389)3.55087141
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53978266
71amino acid salvage (GO:0043102)3.49220677
72L-methionine salvage (GO:0071267)3.49220677
73L-methionine biosynthetic process (GO:0071265)3.49220677
74neutral lipid biosynthetic process (GO:0046460)3.43913851
75acylglycerol biosynthetic process (GO:0046463)3.43913851
76quaternary ammonium group transport (GO:0015697)3.43277874
77meiotic nuclear division (GO:0007126)3.40467923
78regulation of hippo signaling (GO:0035330)3.37931418
79indolalkylamine metabolic process (GO:0006586)3.37830193
80kynurenine metabolic process (GO:0070189)3.36446156
81photoreceptor cell maintenance (GO:0045494)3.34630433
82sex differentiation (GO:0007548)3.31087943
83neural tube formation (GO:0001841)3.30883027
84meiosis I (GO:0007127)3.29552222
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28211985
86biotin metabolic process (GO:0006768)3.25603118
87reflex (GO:0060004)3.24733335
88CDP-diacylglycerol biosynthetic process (GO:0016024)3.20663433
89establishment of protein localization to Golgi (GO:0072600)3.20456949
90multicellular organismal development (GO:0007275)3.16411969
91regulation of protein kinase A signaling (GO:0010738)3.16310188
92righting reflex (GO:0060013)3.16306610
93positive regulation of glycolytic process (GO:0045821)3.15866408
94methionine biosynthetic process (GO:0009086)3.13921674
95regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.12615821
96intraciliary transport (GO:0042073)3.11104773
97cilium assembly (GO:0042384)3.10888703
98tryptophan metabolic process (GO:0006568)3.09104877
99glycerolipid catabolic process (GO:0046503)3.07861951
100regulation of posttranscriptional gene silencing (GO:0060147)3.06929006
101regulation of gene silencing by miRNA (GO:0060964)3.06929006
102regulation of gene silencing by RNA (GO:0060966)3.06929006
103protein localization to cilium (GO:0061512)3.03856849
104regulation of acrosome reaction (GO:0060046)3.03058300
105sexual reproduction (GO:0019953)3.02881747
106chromosome condensation (GO:0030261)3.00171033
107monoubiquitinated protein deubiquitination (GO:0035520)3.00115389
108single strand break repair (GO:0000012)3.00019714
109regulation of cholesterol storage (GO:0010885)2.98903461
110DNA packaging (GO:0006323)2.98604122
111valine metabolic process (GO:0006573)2.97525819
112negative regulation of keratinocyte proliferation (GO:0010839)2.97075381
113lipid storage (GO:0019915)2.96176185
114axoneme assembly (GO:0035082)2.93180703
115aromatic amino acid family catabolic process (GO:0009074)2.90901837
116regulation of acyl-CoA biosynthetic process (GO:0050812)2.86849877
117glycolytic process (GO:0006096)2.83642865
118sphingoid metabolic process (GO:0046519)2.83445467
119cilium morphogenesis (GO:0060271)2.81887518
120negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.81675454
121benzene-containing compound metabolic process (GO:0042537)2.78614570
122phosphatidic acid metabolic process (GO:0046473)2.77935255
123phosphatidic acid biosynthetic process (GO:0006654)2.77935255
124nucleoside diphosphate catabolic process (GO:0009134)2.77501124
125coenzyme catabolic process (GO:0009109)2.77496986
126polyol catabolic process (GO:0046174)2.75176374
127protein K11-linked deubiquitination (GO:0035871)2.75152561
128methionine metabolic process (GO:0006555)2.74021487
129regulation of establishment of cell polarity (GO:2000114)2.73590647
130response to nitrosative stress (GO:0051409)2.72901577
131meiotic cell cycle (GO:0051321)2.72140888
132fatty acid beta-oxidation (GO:0006635)2.72063252
133CDP-diacylglycerol metabolic process (GO:0046341)2.71836429
134protein polyglutamylation (GO:0018095)2.69868979
135positive regulation of fatty acid oxidation (GO:0046321)2.69222398
136tachykinin receptor signaling pathway (GO:0007217)2.68395249
137synapsis (GO:0007129)2.67957892
138regulation of glucokinase activity (GO:0033131)2.67806085
139regulation of hexokinase activity (GO:1903299)2.67806085
140protein targeting to Golgi (GO:0000042)2.66277198
141cilium organization (GO:0044782)2.65884744
142DNA double-strand break processing (GO:0000729)2.65743462
143regulation of sulfur metabolic process (GO:0042762)2.64849993
144positive regulation of fatty acid beta-oxidation (GO:0032000)2.63874164
145detection of light stimulus involved in visual perception (GO:0050908)2.63026406
146detection of light stimulus involved in sensory perception (GO:0050962)2.63026406
147aspartate family amino acid biosynthetic process (GO:0009067)2.61349711
148sulfur amino acid biosynthetic process (GO:0000097)2.59971233
149regulation of coenzyme metabolic process (GO:0051196)2.58154774
150regulation of cofactor metabolic process (GO:0051193)2.58154774
151negative regulation of complement activation (GO:0045916)2.57653585
152water-soluble vitamin biosynthetic process (GO:0042364)2.52589742
153cytoplasmic mRNA processing body assembly (GO:0033962)2.52088569
154aromatic amino acid family metabolic process (GO:0009072)2.51698232
155L-fucose catabolic process (GO:0042355)2.51090572
156fucose catabolic process (GO:0019317)2.51090572
157L-fucose metabolic process (GO:0042354)2.51090572
158ADP metabolic process (GO:0046031)2.48981791
159androgen biosynthetic process (GO:0006702)2.48857205
160negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48217796
161negative regulation of translation, ncRNA-mediated (GO:0040033)2.48217796
162regulation of translation, ncRNA-mediated (GO:0045974)2.48217796
163auditory receptor cell stereocilium organization (GO:0060088)2.47899994
164peptidyl-threonine dephosphorylation (GO:0035970)2.47652493
165regulation of keratinocyte proliferation (GO:0010837)2.47574299
166bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47182417
167thyroid hormone metabolic process (GO:0042403)2.46298402
168intestinal epithelial cell development (GO:0060576)2.46282705
169cellular component assembly involved in morphogenesis (GO:0010927)2.44648130
170gene silencing by RNA (GO:0031047)2.40665506
171retrograde transport, vesicle recycling within Golgi (GO:0000301)2.40296157
172snRNA transcription (GO:0009301)2.40222539
173negative regulation of protein activation cascade (GO:2000258)2.39934971
174regulation of establishment or maintenance of cell polarity (GO:0032878)2.39244620
175indole-containing compound metabolic process (GO:0042430)2.35151358
176peptidyl-histidine modification (GO:0018202)2.34546316
177fusion of sperm to egg plasma membrane (GO:0007342)11.8574925
178sperm motility (GO:0030317)11.8338632
179cell wall macromolecule metabolic process (GO:0044036)10.3313976
180cell wall macromolecule catabolic process (GO:0016998)10.3313976
181acrosome reaction (GO:0007340)10.1262179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.80425034
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.42684423
3EZH2_22144423_ChIP-Seq_EOC_Human4.02019692
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54132459
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14417646
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.98301248
7IGF1R_20145208_ChIP-Seq_DFB_Human2.92570336
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70897373
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57930613
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57885512
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48267202
12FUS_26573619_Chip-Seq_HEK293_Human2.40655507
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.32456152
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22211980
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.18208182
16PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.08182526
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07331672
18P300_19829295_ChIP-Seq_ESCs_Human2.07012249
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05969149
20PIAS1_25552417_ChIP-Seq_VCAP_Human2.02081469
21EWS_26573619_Chip-Seq_HEK293_Human1.95067842
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93378515
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91350624
24STAT3_23295773_ChIP-Seq_U87_Human1.88461322
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87809086
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82782081
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76689308
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74320824
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.68496763
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66849548
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65381472
32STAT1_17558387_ChIP-Seq_HELA_Human1.65080327
33BCAT_22108803_ChIP-Seq_LS180_Human1.64076158
34CBP_20019798_ChIP-Seq_JUKART_Human1.63696199
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63696199
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63192971
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.62018874
38VDR_22108803_ChIP-Seq_LS180_Human1.61942370
39KDM2B_26808549_Chip-Seq_REH_Human1.58832256
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58360345
41AR_25329375_ChIP-Seq_VCAP_Human1.55599745
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.53671414
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53450214
44TCF4_22108803_ChIP-Seq_LS180_Human1.52544884
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52155574
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.51835939
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51148470
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51132850
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49433168
50ZNF274_21170338_ChIP-Seq_K562_Hela1.48738231
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48501857
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.47358822
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.46773245
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46546192
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45795868
56CDX2_22108803_ChIP-Seq_LS180_Human1.45403237
57AHR_22903824_ChIP-Seq_MCF-7_Human1.44236944
58TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.43177395
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.41628922
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41478673
61WDR5_24793694_ChIP-Seq_LNCAP_Human1.40979319
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39698535
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36954554
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36918086
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35214140
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35117903
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34690098
68KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32993145
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32445690
70RUNX2_22187159_ChIP-Seq_PCA_Human1.32297526
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.31280260
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.30413056
73FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30314778
74TAF15_26573619_Chip-Seq_HEK293_Human1.30204553
75SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30069093
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27711241
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27603224
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27479358
79IRF1_19129219_ChIP-ChIP_H3396_Human1.24298955
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21710817
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21666785
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21234136
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20965637
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20965637
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19818389
86P53_22387025_ChIP-Seq_ESCs_Mouse1.19644835
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19459655
88GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.15589814
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.15153983
90SOX2_19829295_ChIP-Seq_ESCs_Human1.15119918
91NANOG_19829295_ChIP-Seq_ESCs_Human1.15119918
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14680614
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.14489725
94CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13967894
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.13505123
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13251455
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12266670
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11660930
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11585970
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11168280
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10992630
102TP53_22573176_ChIP-Seq_HFKS_Human1.10626686
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10251457
104GF1_26923725_Chip-Seq_HPCs_Mouse1.10149573
105P300_18555785_Chip-Seq_ESCs_Mouse1.09977516
106GBX2_23144817_ChIP-Seq_PC3_Human1.08541661
107RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08485315
108REST_21632747_ChIP-Seq_MESCs_Mouse1.07911704
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.06852109
110HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06306966
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.06175829
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05711791
113TP53_18474530_ChIP-ChIP_U2OS_Human1.05291009
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.04571694
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04440989
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04356539
117ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03972744
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.03740887
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03329395
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02836963
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.02836963
122PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.02557037
123ERG_20517297_ChIP-Seq_VCAP_Human1.02381760
124ER_23166858_ChIP-Seq_MCF-7_Human1.02110940
125TP63_23658742_ChIP-Seq_EP156T_Human1.01297228
126KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01070575
127RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00848975
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00703807
129TCF4_18268006_ChIP-ChIP_LS174T_Human1.00680185
130FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00511743
131HOXB7_26014856_ChIP-Seq_BT474_Human1.00475616
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99813285
133SOX2_18555785_Chip-Seq_ESCs_Mouse0.99256179
134AR_20517297_ChIP-Seq_VCAP_Human0.99198190
135GATA3_21867929_ChIP-Seq_CD8_Mouse0.99169458
136KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98541367
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98415984
138P53_21459846_ChIP-Seq_SAOS-2_Human0.98304836
139GATA3_21867929_ChIP-Seq_TH1_Mouse0.98168566
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.97874108
141TCF4_23295773_ChIP-Seq_U87_Human0.97234351
142ELK1_19687146_ChIP-ChIP_HELA_Human0.97079635
143VDR_24787735_ChIP-Seq_THP-1_Human0.96835462
144PU1_27457419_Chip-Seq_LIVER_Mouse0.96026781
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94813110
146CTCF_18555785_Chip-Seq_ESCs_Mouse0.94633567
147TBL1_22424771_ChIP-Seq_293T_Human0.91978443
148SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91654334
149CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91589308
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91560460
151SMAD4_21799915_ChIP-Seq_A2780_Human0.90995881
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90378108
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.89941383
154LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.89805887
155Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89581599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.28248686
2MP0005666_abnormal_adipose_tissue4.40699989
3MP0003698_abnormal_male_reproductive4.34026105
4MP0001929_abnormal_gametogenesis3.78727619
5MP0004130_abnormal_muscle_cell3.38893318
6MP0008057_abnormal_DNA_replication3.13477000
7MP0005375_adipose_tissue_phenotype3.04219679
8MP0004185_abnormal_adipocyte_glucose2.97906715
9MP0003195_calcinosis2.96844839
10MP0008877_abnormal_DNA_methylation2.71421541
11MP0002971_abnormal_brown_adipose2.62694888
12MP0010234_abnormal_vibrissa_follicle2.62525186
13MP0002210_abnormal_sex_determination2.42085372
14MP0010678_abnormal_skin_adnexa2.40845352
15MP0009115_abnormal_fat_cell2.31096129
16MP0002161_abnormal_fertility/fecundity2.30684868
17MP0000383_abnormal_hair_follicle2.21932097
18MP0003718_maternal_effect2.21466302
19MP0002876_abnormal_thyroid_physiology2.09926876
20MP0000013_abnormal_adipose_tissue2.00246235
21MP0005410_abnormal_fertilization11.6443673
22MP0009697_abnormal_copulation1.91843440
23MP0001145_abnormal_male_reproductive1.89589254
24MP0008438_abnormal_cutaneous_collagen1.89040637
25MP0005334_abnormal_fat_pad1.87340293
26MP0000003_abnormal_adipose_tissue1.79311428
27MP0010386_abnormal_urinary_bladder1.78954868
28MP0002736_abnormal_nociception_after1.77853536
29MP0003646_muscle_fatigue1.75758820
30MP0002837_dystrophic_cardiac_calcinosis1.75744367
31MP0002139_abnormal_hepatobiliary_system1.72157551
32MP0005551_abnormal_eye_electrophysiolog1.71986720
33MP0001661_extended_life_span1.66681393
34MP0000653_abnormal_sex_gland1.63189901
35MP0004264_abnormal_extraembryonic_tissu1.62033593
36MP0002970_abnormal_white_adipose1.59663748
37MP0006072_abnormal_retinal_apoptosis1.56443777
38MP0005646_abnormal_pituitary_gland1.54907767
39MP0008875_abnormal_xenobiotic_pharmacok1.54832628
40MP0005085_abnormal_gallbladder_physiolo1.54815828
41MP0010329_abnormal_lipoprotein_level1.54531242
42MP0005253_abnormal_eye_physiology1.53220775
43MP0003252_abnormal_bile_duct1.52710658
44MP0003941_abnormal_skin_development1.50106583
45MP0004133_heterotaxia1.44657628
46MP0005535_abnormal_body_temperature1.43809045
47MP0005248_abnormal_Harderian_gland1.42227407
48MP0005395_other_phenotype1.41462348
49MP0003959_abnormal_lean_body1.40717721
50MP0002928_abnormal_bile_duct1.37143001
51MP0001968_abnormal_touch/_nociception1.37032750
52MP0003890_abnormal_embryonic-extraembry1.36491240
53MP0002653_abnormal_ependyma_morphology1.35656215
54MP0004043_abnormal_pH_regulation1.31253239
55MP0003787_abnormal_imprinting1.31041585
56MP0008058_abnormal_DNA_repair1.29181345
57MP0001529_abnormal_vocalization1.28457563
58MP0002118_abnormal_lipid_homeostasis1.26497536
59MP0005275_abnormal_skin_tensile1.25241112
60MP0000538_abnormal_urinary_bladder1.16480281
61MP0008872_abnormal_physiological_respon1.15803024
62MP0002138_abnormal_hepatobiliary_system1.13304142
63MP0005647_abnormal_sex_gland1.12719937
64MP0005623_abnormal_meninges_morphology1.12475274
65MP0006276_abnormal_autonomic_nervous1.12229580
66MP0003136_yellow_coat_color1.11556018
67MP0003868_abnormal_feces_composition1.10244547
68MP0003806_abnormal_nucleotide_metabolis1.09328723
69MP0010094_abnormal_chromosome_stability1.09220799
70MP0003937_abnormal_limbs/digits/tail_de1.08556360
71MP0009745_abnormal_behavioral_response1.08330708
72MP0001666_abnormal_nutrient_absorption1.07564685
73MP0000647_abnormal_sebaceous_gland1.06060141
74MP0002938_white_spotting1.05660399
75MP0005332_abnormal_amino_acid1.05090457
76MP0001485_abnormal_pinna_reflex1.04468428
77MP0003943_abnormal_hepatobiliary_system1.04300590
78MP0002234_abnormal_pharynx_morphology1.02937517
79MP0002160_abnormal_reproductive_system1.02623111
80MP0000631_abnormal_neuroendocrine_gland1.02202211
81MP0005448_abnormal_energy_balance1.01859269
82MP0003121_genomic_imprinting1.01834772
83MP0002102_abnormal_ear_morphology1.01503821
84MP0001944_abnormal_pancreas_morphology1.00305837
85MP0003045_fibrosis0.98773141
86MP0005220_abnormal_exocrine_pancreas0.98263833
87MP0002693_abnormal_pancreas_physiology0.98115525
88MP0003191_abnormal_cellular_cholesterol0.97856849
89MP0005452_abnormal_adipose_tissue0.97633750
90MP0003119_abnormal_digestive_system0.95770578
91MP0004147_increased_porphyrin_level0.94576046
92MP0010352_gastrointestinal_tract_polyps0.93666276
93MP0003122_maternal_imprinting0.92024453
94MP0001764_abnormal_homeostasis0.91365209
95MP0002638_abnormal_pupillary_reflex0.90276456
96MP0003693_abnormal_embryo_hatching0.87516405
97MP0003950_abnormal_plasma_membrane0.87495340
98MP0002090_abnormal_vision0.85303618
99MP0000516_abnormal_urinary_system0.85247343
100MP0005367_renal/urinary_system_phenotyp0.85247343
101MP0002233_abnormal_nose_morphology0.83849959
102MP0001765_abnormal_ion_homeostasis0.82667519
103MP0003724_increased_susceptibility_to0.81329466
104MP0005645_abnormal_hypothalamus_physiol0.79856888
105MP0002078_abnormal_glucose_homeostasis0.78573663
106MP0005266_abnormal_metabolism0.77751279
107MP0001727_abnormal_embryo_implantation0.77470876
108MP0005084_abnormal_gallbladder_morpholo0.75529517
109MP0001501_abnormal_sleep_pattern0.74011594
110MP0002557_abnormal_social/conspecific_i0.72614855
111MP0000569_abnormal_digit_pigmentation0.72613441
112MP0000372_irregular_coat_pigmentation0.72576918
113MP0006138_congestive_heart_failure0.71801660
114MP0002909_abnormal_adrenal_gland0.70816422
115MP0004272_abnormal_basement_membrane0.69948960
116MP0002229_neurodegeneration0.69516505
117MP0003948_abnormal_gas_homeostasis0.69106103
118MP0003690_abnormal_glial_cell0.67567407
119MP0001984_abnormal_olfaction0.64774240
120MP0003953_abnormal_hormone_level0.64614300
121MP0006036_abnormal_mitochondrial_physio0.63518572
122MP0003011_delayed_dark_adaptation0.61504315
123MP0002282_abnormal_trachea_morphology0.60744647
124MP0003828_pulmonary_edema0.59139381
125MP0009046_muscle_twitch0.58459064
126MP0004233_abnormal_muscle_weight0.58153017
127MP0005389_reproductive_system_phenotype0.56305694
128MP0008961_abnormal_basal_metabolism0.56175843
129MP0000609_abnormal_liver_physiology0.56080556
130MP0001545_abnormal_hematopoietic_system0.55265393
131MP0005397_hematopoietic_system_phenotyp0.55265393
132MP0000751_myopathy0.54527387
133MP0002796_impaired_skin_barrier0.54489994
134MP0008995_early_reproductive_senescence0.53232357
135MP0005379_endocrine/exocrine_gland_phen0.50009896
136MP0005365_abnormal_bile_salt0.49869163
137MP0009780_abnormal_chondrocyte_physiolo0.48432960
138MP0001986_abnormal_taste_sensitivity0.47898251
139MP0002168_other_aberrant_phenotype0.45730529
140MP0002060_abnormal_skin_morphology0.45321667
141MP0005620_abnormal_muscle_contractility0.42442976
142MP0000343_altered_response_to0.42067535
143MP0003186_abnormal_redox_activity0.41388054
144MP0009672_abnormal_birth_weight0.39617098
145MP0000759_abnormal_skeletal_muscle0.39170640
146MP0002009_preneoplasia0.38106788
147MP0001881_abnormal_mammary_gland0.38078992
148MP0003699_abnormal_female_reproductive0.37518853
149MP0005584_abnormal_enzyme/coenzyme_acti0.37238050
150MP0008775_abnormal_heart_ventricle0.37109490
151MP0005319_abnormal_enzyme/_coenzyme0.35458361
152MP0003878_abnormal_ear_physiology0.35212737
153MP0005377_hearing/vestibular/ear_phenot0.35212737
154MP0002108_abnormal_muscle_morphology0.34747270
155MP0000427_abnormal_hair_cycle0.34333649
156MP0004019_abnormal_vitamin_homeostasis0.34042367
157MP0002133_abnormal_respiratory_system0.33469278
158MP0005388_respiratory_system_phenotype0.33469278
159MP0003115_abnormal_respiratory_system0.32627855
160MP0002254_reproductive_system_inflammat0.32505833
161MP0001324_abnormal_eye_pigmentation0.32198752
162MP0003879_abnormal_hair_cell0.31525531
163MP0000750_abnormal_muscle_regeneration0.31213775
164MP0001544_abnormal_cardiovascular_syste0.30453592
165MP0005385_cardiovascular_system_phenoty0.30453592
166MP0002295_abnormal_pulmonary_circulatio0.29805313

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.66316031
2Abnormal respiratory motile cilium morphology (HP:0005938)8.39135863
3Abnormal respiratory epithelium morphology (HP:0012253)8.39135863
4Abnormal ciliary motility (HP:0012262)7.20080397
5Rhinitis (HP:0012384)6.65919327
6Infertility (HP:0000789)6.15691317
7Chronic bronchitis (HP:0004469)5.95347530
8Nasal polyposis (HP:0100582)5.68281025
9Abnormality of the nasal mucosa (HP:0000433)4.67234390
10Male infertility (HP:0003251)4.33244413
11Nephronophthisis (HP:0000090)4.12951419
12Bronchiectasis (HP:0002110)4.02159206
13Oligomenorrhea (HP:0000876)3.92507400
14Pancreatic cysts (HP:0001737)3.90675429
15Bronchitis (HP:0012387)3.77824260
16True hermaphroditism (HP:0010459)3.68349927
17Abnormal spermatogenesis (HP:0008669)3.53142208
18Recurrent sinusitis (HP:0011108)3.36620893
19Acanthosis nigricans (HP:0000956)3.36076747
20Chronic hepatic failure (HP:0100626)3.34863866
21Tubulointerstitial nephritis (HP:0001970)3.22425647
22Abnormality of the renal medulla (HP:0100957)3.19212101
23Gaze-evoked nystagmus (HP:0000640)3.18495728
24Hypertriglyceridemia (HP:0002155)3.04240995
25Genetic anticipation (HP:0003743)2.97801312
26Recurrent otitis media (HP:0000403)2.88971311
27Gonadotropin excess (HP:0000837)2.88136498
28Tubulointerstitial abnormality (HP:0001969)2.81572215
29Progressive cerebellar ataxia (HP:0002073)2.78596935
30Insulin-resistant diabetes mellitus (HP:0000831)2.72064138
31Azoospermia (HP:0000027)2.60252461
32Hemorrhage of the eye (HP:0011885)2.57009564
33Attenuation of retinal blood vessels (HP:0007843)2.52990040
34Occipital encephalocele (HP:0002085)2.50780608
35Fibular hypoplasia (HP:0003038)2.45454148
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.40435536
37Abnormality of macular pigmentation (HP:0008002)2.37057388
38Abnormality of midbrain morphology (HP:0002418)2.36748855
39Molar tooth sign on MRI (HP:0002419)2.36748855
40Myoglobinuria (HP:0002913)2.35573385
41Bony spicule pigmentary retinopathy (HP:0007737)2.33929804
42Recurrent bronchitis (HP:0002837)2.32808747
43Abnormality of the renal cortex (HP:0011035)2.32205113
44Abnormal protein glycosylation (HP:0012346)2.30491029
45Abnormal glycosylation (HP:0012345)2.30491029
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30491029
47Abnormal protein N-linked glycosylation (HP:0012347)2.30491029
48Sclerocornea (HP:0000647)2.30053433
49Hyperventilation (HP:0002883)2.29615094
50Long foot (HP:0001833)2.28677205
51Progressive inability to walk (HP:0002505)2.28141728
52Congenital primary aphakia (HP:0007707)2.28117090
53Tubulointerstitial fibrosis (HP:0005576)2.26470176
54Furrowed tongue (HP:0000221)2.25491379
55Inability to walk (HP:0002540)2.22301838
56Proximal tubulopathy (HP:0000114)2.20998587
57Congenital sensorineural hearing impairment (HP:0008527)2.20776781
58Gait imbalance (HP:0002141)2.19326440
59Ketoacidosis (HP:0001993)2.18378226
60Subcapsular cataract (HP:0000523)2.18073582
61Medial flaring of the eyebrow (HP:0010747)2.15093286
62Bell-shaped thorax (HP:0001591)2.13828720
63Type I transferrin isoform profile (HP:0003642)2.13560267
64Genital tract atresia (HP:0001827)2.13100570
65Dysmetric saccades (HP:0000641)2.12929307
66Hyperglycinemia (HP:0002154)2.12549897
67Fair hair (HP:0002286)2.11101765
68Biliary tract neoplasm (HP:0100574)2.09036748
69Tubular atrophy (HP:0000092)2.06888948
70Male pseudohermaphroditism (HP:0000037)2.06163349
71Hypothermia (HP:0002045)2.05256599
72Vaginal atresia (HP:0000148)2.04458448
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03675931
74Abnormality of alanine metabolism (HP:0010916)2.03675931
75Hyperalaninemia (HP:0003348)2.03675931
76Type II lissencephaly (HP:0007260)2.03393632
77Impulsivity (HP:0100710)2.03349872
78Stage 5 chronic kidney disease (HP:0003774)2.01332796
79Abnormal biliary tract physiology (HP:0012439)2.00571219
80Bile duct proliferation (HP:0001408)2.00571219
81Rhabdomyolysis (HP:0003201)2.00455758
82Dynein arm defect of respiratory motile cilia (HP:0012255)12.4579386
83Absent/shortened dynein arms (HP:0200106)12.4579386
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0567861
85Central scotoma (HP:0000603)1.99339403
86Abnormality of the labia minora (HP:0012880)1.98921615
87Nephrogenic diabetes insipidus (HP:0009806)1.96847467
88Postaxial foot polydactyly (HP:0001830)1.96353652
89Hypoplastic labia majora (HP:0000059)1.95732065
90Dyschromatopsia (HP:0007641)1.91928118
91Hyperglycinuria (HP:0003108)1.90856817
92Prolonged partial thromboplastin time (HP:0003645)1.89603642
93Difficulty running (HP:0009046)1.88129464
94Ketosis (HP:0001946)1.87396672
95Decreased central vision (HP:0007663)1.84388999
96Retinitis pigmentosa (HP:0000510)1.83975754
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.83773647
98Dialeptic seizures (HP:0011146)1.82699075
99Preaxial hand polydactyly (HP:0001177)1.82698676
100Abnormal biliary tract morphology (HP:0012440)1.79527465
101Hyperpituitarism (HP:0010514)1.78528919
102Reduced antithrombin III activity (HP:0001976)1.77588906
103Absent speech (HP:0001344)1.77234160
104Poor coordination (HP:0002370)1.76024592
105Large for gestational age (HP:0001520)1.75591976
106Retinal dysplasia (HP:0007973)1.75089480
107Abnormality of the labia majora (HP:0012881)1.74329347
108Cerebellar dysplasia (HP:0007033)1.73676017
109Abolished electroretinogram (ERG) (HP:0000550)1.73364195
110Labial hypoplasia (HP:0000066)1.72072089
111Congenital hepatic fibrosis (HP:0002612)1.72005278
112Anencephaly (HP:0002323)1.71829832
113Protruding tongue (HP:0010808)1.71687032
114Cholecystitis (HP:0001082)1.70295397
115Abnormal gallbladder physiology (HP:0012438)1.70295397
116Abnormality of the astrocytes (HP:0100707)1.69903911
117Astrocytoma (HP:0009592)1.69903911
118Hypoglycemic coma (HP:0001325)1.69200071
119Hypobetalipoproteinemia (HP:0003563)1.69172347
120Neoplasm of the adrenal cortex (HP:0100641)1.67373355
121Amelogenesis imperfecta (HP:0000705)1.67220259
122Absence seizures (HP:0002121)1.66549947
123Ependymoma (HP:0002888)1.65680208
124Insulin resistance (HP:0000855)1.64271270
125Breast carcinoma (HP:0003002)1.64087470
126Heterotopia (HP:0002282)1.63533233
127Glioma (HP:0009733)1.62991800
128Cystic liver disease (HP:0006706)1.62432085
129Hypoplastic female external genitalia (HP:0012815)1.61981079
130Truncal obesity (HP:0001956)1.60348374
131Pigmentary retinal degeneration (HP:0001146)1.59269898
132Easy fatigability (HP:0003388)1.59256284
133Decreased electroretinogram (ERG) amplitude (HP:0000654)1.57711066
134Hyperkalemia (HP:0002153)1.57525344
135Spastic tetraparesis (HP:0001285)1.55970190
136Abnormality of molar (HP:0011077)1.52284447
137Abnormality of molar morphology (HP:0011070)1.52284447
138Complement deficiency (HP:0004431)1.50242277
139Oculomotor apraxia (HP:0000657)1.48687851
140Hypercholesterolemia (HP:0003124)1.47566232
141Choroideremia (HP:0001139)1.47100663
142Epidermoid cyst (HP:0200040)1.46338289
143Tetraparesis (HP:0002273)1.46202743
144Glucose intolerance (HP:0000833)1.46129195
145Abnormality of the dental root (HP:0006486)1.44439497
146Taurodontia (HP:0000679)1.44439497
147Abnormality of permanent molar morphology (HP:0011071)1.44439497
148Asymmetric septal hypertrophy (HP:0001670)1.40913307
149Pancreatic fibrosis (HP:0100732)1.40643374
150Nephropathy (HP:0000112)1.39771653
151Growth hormone excess (HP:0000845)1.39415121
152Thyroid-stimulating hormone excess (HP:0002925)1.39199942
153Hyporeflexia of lower limbs (HP:0002600)1.38868266
154Hypoalphalipoproteinemia (HP:0003233)1.37741500
155Accelerated skeletal maturation (HP:0005616)1.37260248
156Aplasia/Hypoplasia of the fibula (HP:0006492)1.36802449
157Absent frontal sinuses (HP:0002688)1.36459991
158Abnormality of glycine metabolism (HP:0010895)1.36238189
159Abnormality of serine family amino acid metabolism (HP:0010894)1.36238189
160Renal cortical cysts (HP:0000803)1.36178189
161Exercise-induced myalgia (HP:0003738)1.34284512
162Sensory axonal neuropathy (HP:0003390)1.34214520
163Postaxial hand polydactyly (HP:0001162)1.32490271
164Hyperthyroidism (HP:0000836)1.31296291
165Polyphagia (HP:0002591)1.30785533
166Polycystic ovaries (HP:0000147)1.30742747
167Abnormality of the dental pulp (HP:0006479)1.30733569
168Bundle branch block (HP:0011710)1.28839366
169Abnormal drinking behavior (HP:0030082)1.28471397
170Polydipsia (HP:0001959)1.28471397
171Short ribs (HP:0000773)1.27937640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.31057436
2PDK48.31057436
3PDK25.45046643
4PRKD34.69910275
5TESK13.98924155
6ICK3.70685871
7MST43.28110584
8CAMK1D2.90202765
9CAMK1G2.83727982
10BMPR1B2.49154534
11MAP4K22.41889144
12WNK31.96205484
13TRIM281.91796660
14PTK2B1.88403063
15ACVR1B1.76709802
16OXSR11.66600806
17BCR1.64278927
18NUAK11.61935264
19EIF2AK31.61287542
20ZAK1.57527118
21MAP3K41.53457320
22STK381.49855658
23MKNK21.46035926
24ERBB31.41895303
25PBK1.40893163
26TRIB31.39496832
27WNK41.39451138
28LMTK21.38695091
29SIK11.34975415
30MAP2K71.30332757
31STK391.28697377
32TSSK61.23528710
33PDK11.18118660
34ADRBK21.16645823
35PNCK1.16392723
36NTRK31.08982594
37INSRR1.07800010
38EIF2AK11.04514422
39IRAK11.04429732
40MST1R1.03332342
41BCKDK1.02784299
42TNIK1.02748347
43EPHA20.99931445
44PRKCE0.98815213
45DYRK1B0.93332940
46PLK40.92889992
47PLK30.92750252
48CSNK1G10.90492410
49NEK20.87369731
50PRKAA20.86986084
51PINK10.85926715
52MKNK10.83581202
53CDK190.83354888
54PLK20.82225948
55BRD40.81126299
56PDPK10.78900321
57CSNK1A1L0.75154459
58PAK30.74765615
59STK30.74659660
60MAPK130.73438632
61STK38L0.72072527
62PLK10.71963686
63FRK0.71203187
64CDK90.71108252
65CSNK1G30.70918844
66MAPKAPK30.69596598
67WNK10.69269064
68CASK0.69097284
69NME10.66481488
70CSNK1G20.66433918
71IRAK20.66300812
72LATS10.64372504
73MAP3K120.64135171
74MAPK150.63319763
75MAP3K90.63275276
76STK240.63225920
77PRKAA10.62021274
78NLK0.57675017
79TGFBR10.53905910
80RPS6KA40.53733864
81RPS6KB20.53216323
82RIPK10.52228655
83MARK30.51327326
84NEK10.48430169
85TAF10.47881239
86EIF2AK20.47241450
87MAP3K20.47094870
88BUB10.46852942
89ADRBK10.46576743
90WEE10.46439596
91MARK20.46367773
92PRKCI0.44857817
93TLK10.44273790
94YES10.44083602
95AKT30.43104114
96FGFR20.42798885
97MTOR0.41462013
98TYRO30.40475482
99CDK60.40466207
100CAMK10.40131705
101PIK3CG0.39859980
102TIE10.38710679
103FLT30.38645144
104MELK0.37505090
105CDC70.36950250
106FGFR10.36871424
107MAP2K60.36464206
108CHEK20.34094931
109SRPK10.33282307
110NEK60.33017799
111RPS6KB10.32999112
112TTK0.32412804
113CSNK1D0.31718373
114DYRK30.30949640
115CSNK1A10.30522286
116FGFR30.29791070
117EEF2K0.29445798
118TRPM70.28914605
119TGFBR20.28733578
120PRKD20.27871735
121CAMK2A0.26503046
122CAMK2D0.26209333
123PRKACG0.25789654
124CDK30.25471170
125CAMKK20.25328919
126PAK20.23872848
127MUSK0.23588547
128ERN10.23473566
129PRKCH0.20198440
130CDK120.19498630
131EPHB20.18884038
132JAK10.17760370
133TNK20.17582051
134IGF1R0.17373795
135STK110.17242856
136RIPK40.16545763
137CCNB10.16529991
138CSF1R0.15822273
139MET0.15771415
140NTRK20.15281058
141GRK10.15200848
142CDK40.14905978
143GSK3A0.11246641
144PRKG10.11107004
145INSR0.10599853
146PRKCZ0.10558016
147PRKG20.10447108
148ATM0.10123821
149PKN10.09470887
150CAMKK10.09013809
151PDGFRB0.08069186
152CHEK10.06886499
153PRKACA0.06594919
154PIK3CA0.06496182
155PAK10.05971729
156MAP3K60.05781204
157RPS6KA30.05640460
158PHKG20.04832813
159PHKG10.04832813
160PASK0.04654835
161BRSK20.04530359
162SRC0.04372263
163ATR0.03974496
164MAPKAPK50.03922202
165MAPK80.03636602
166FER0.03102668
167PRKCG0.02353020

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.00078432
2Propanoate metabolism_Homo sapiens_hsa006404.78068898
3PPAR signaling pathway_Homo sapiens_hsa033203.95401579
4Pyruvate metabolism_Homo sapiens_hsa006203.32946001
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.29555815
6Glycerolipid metabolism_Homo sapiens_hsa005613.24610588
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11696798
8Fatty acid metabolism_Homo sapiens_hsa012123.08240277
9Vitamin B6 metabolism_Homo sapiens_hsa007503.07733293
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60976376
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.59701723
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.55311212
13Fatty acid degradation_Homo sapiens_hsa000712.49140448
14Glucagon signaling pathway_Homo sapiens_hsa049222.15063129
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03383790
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.03144505
17Tryptophan metabolism_Homo sapiens_hsa003802.02579462
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01466557
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.93377771
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93356999
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.89721087
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.82256591
23Linoleic acid metabolism_Homo sapiens_hsa005911.81828446
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80930174
25Carbon metabolism_Homo sapiens_hsa012001.67790001
26AMPK signaling pathway_Homo sapiens_hsa041521.63481785
27Retinol metabolism_Homo sapiens_hsa008301.63267887
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.62373616
29Fat digestion and absorption_Homo sapiens_hsa049751.60427609
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58575618
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52029413
32Non-homologous end-joining_Homo sapiens_hsa034501.45371045
33Renin secretion_Homo sapiens_hsa049241.44684780
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44578319
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42930288
36Sphingolipid metabolism_Homo sapiens_hsa006001.40103204
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36319356
38Histidine metabolism_Homo sapiens_hsa003401.31636298
39Homologous recombination_Homo sapiens_hsa034401.30461780
40Phototransduction_Homo sapiens_hsa047441.30348368
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29359621
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26506064
43Protein export_Homo sapiens_hsa030601.26393214
44Pentose phosphate pathway_Homo sapiens_hsa000301.26171701
45Nitrogen metabolism_Homo sapiens_hsa009101.16158930
46Circadian rhythm_Homo sapiens_hsa047101.15622461
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13507318
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09787046
49Dorso-ventral axis formation_Homo sapiens_hsa043201.05304040
50N-Glycan biosynthesis_Homo sapiens_hsa005101.01608850
51Fructose and mannose metabolism_Homo sapiens_hsa000511.00717187
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98994817
53RNA polymerase_Homo sapiens_hsa030200.98280891
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97894983
55One carbon pool by folate_Homo sapiens_hsa006700.96552451
56Lysine degradation_Homo sapiens_hsa003100.96018102
57beta-Alanine metabolism_Homo sapiens_hsa004100.95788121
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95543413
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.93398028
60Olfactory transduction_Homo sapiens_hsa047400.92772517
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87792476
62Steroid biosynthesis_Homo sapiens_hsa001000.87739479
63ABC transporters_Homo sapiens_hsa020100.86007048
64Nicotine addiction_Homo sapiens_hsa050330.85543680
65Basal transcription factors_Homo sapiens_hsa030220.82236957
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81912173
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81022359
68Peroxisome_Homo sapiens_hsa041460.80398873
69Insulin signaling pathway_Homo sapiens_hsa049100.78675441
70Insulin resistance_Homo sapiens_hsa049310.76573225
71RNA degradation_Homo sapiens_hsa030180.75484282
72Arachidonic acid metabolism_Homo sapiens_hsa005900.74831202
73Starch and sucrose metabolism_Homo sapiens_hsa005000.74115025
74Arginine and proline metabolism_Homo sapiens_hsa003300.71257796
75Protein digestion and absorption_Homo sapiens_hsa049740.70722398
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70031565
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68278263
78Arginine biosynthesis_Homo sapiens_hsa002200.68250861
79Ether lipid metabolism_Homo sapiens_hsa005650.67326879
80Salivary secretion_Homo sapiens_hsa049700.64991583
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64629299
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62447324
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61425310
84Oocyte meiosis_Homo sapiens_hsa041140.61342149
85Tight junction_Homo sapiens_hsa045300.61107969
86Type II diabetes mellitus_Homo sapiens_hsa049300.60574719
87Fatty acid elongation_Homo sapiens_hsa000620.60455895
88RNA transport_Homo sapiens_hsa030130.59821635
89Regulation of autophagy_Homo sapiens_hsa041400.59724185
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.58783543
91cAMP signaling pathway_Homo sapiens_hsa040240.57311953
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56958067
93Amphetamine addiction_Homo sapiens_hsa050310.55603096
94Mineral absorption_Homo sapiens_hsa049780.55321382
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53540904
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53363698
97Calcium signaling pathway_Homo sapiens_hsa040200.53176695
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51948251
99Selenocompound metabolism_Homo sapiens_hsa004500.50382773
100Fanconi anemia pathway_Homo sapiens_hsa034600.50000320
101Serotonergic synapse_Homo sapiens_hsa047260.49675169
102Huntingtons disease_Homo sapiens_hsa050160.49674843
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.49349953
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49119992
105Mismatch repair_Homo sapiens_hsa034300.48760409
106Proteasome_Homo sapiens_hsa030500.48488818
107Phenylalanine metabolism_Homo sapiens_hsa003600.48228272
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47944512
109Complement and coagulation cascades_Homo sapiens_hsa046100.47090478
110Sulfur metabolism_Homo sapiens_hsa009200.46547038
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43896430
112Vitamin digestion and absorption_Homo sapiens_hsa049770.43342315
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42841639
114Staphylococcus aureus infection_Homo sapiens_hsa051500.42131928
115Caffeine metabolism_Homo sapiens_hsa002320.41040420
116Pyrimidine metabolism_Homo sapiens_hsa002400.40437688
117Renin-angiotensin system_Homo sapiens_hsa046140.40239900
118GABAergic synapse_Homo sapiens_hsa047270.38711687
119Inositol phosphate metabolism_Homo sapiens_hsa005620.36856301
120Glutamatergic synapse_Homo sapiens_hsa047240.36448861
121Thyroid hormone synthesis_Homo sapiens_hsa049180.35436319
122Estrogen signaling pathway_Homo sapiens_hsa049150.35268892
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35119618
124Biosynthesis of amino acids_Homo sapiens_hsa012300.34859317
125Tyrosine metabolism_Homo sapiens_hsa003500.34167065
126Taste transduction_Homo sapiens_hsa047420.32782807
127Autoimmune thyroid disease_Homo sapiens_hsa053200.31881131
128Purine metabolism_Homo sapiens_hsa002300.31684241
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30428216
130Metabolic pathways_Homo sapiens_hsa011000.30170173
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.27746546
132Circadian entrainment_Homo sapiens_hsa047130.25024206
133ECM-receptor interaction_Homo sapiens_hsa045120.24726848
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24489763
135Cardiac muscle contraction_Homo sapiens_hsa042600.24403807
136Insulin secretion_Homo sapiens_hsa049110.24378028
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24253862
138Hedgehog signaling pathway_Homo sapiens_hsa043400.23052282
139Glutathione metabolism_Homo sapiens_hsa004800.22324060
140HIF-1 signaling pathway_Homo sapiens_hsa040660.20226397
141Collecting duct acid secretion_Homo sapiens_hsa049660.19487067
142Legionellosis_Homo sapiens_hsa051340.18271178
143Basal cell carcinoma_Homo sapiens_hsa052170.18127188
144Butanoate metabolism_Homo sapiens_hsa006500.17628431
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17493826
146Chemical carcinogenesis_Homo sapiens_hsa052040.17351018
147Ovarian steroidogenesis_Homo sapiens_hsa049130.15841709
148Gastric acid secretion_Homo sapiens_hsa049710.14861107
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14338802
150Pancreatic secretion_Homo sapiens_hsa049720.12990965
151Morphine addiction_Homo sapiens_hsa050320.12358722
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12335715
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.11612932
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08235800

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