ANKFN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.93496369
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.53168114
3epithelial cilium movement (GO:0003351)9.45618670
4motile cilium assembly (GO:0044458)6.78291856
5axoneme assembly (GO:0035082)6.27398018
6regulation of cilium movement (GO:0003352)5.71274237
7left/right pattern formation (GO:0060972)5.05564641
8cilium organization (GO:0044782)4.89086035
9ventricular system development (GO:0021591)4.86957715
10intraciliary transport (GO:0042073)4.84651092
11cilium assembly (GO:0042384)4.79868458
12cilium morphogenesis (GO:0060271)4.74582676
13negative regulation of cytosolic calcium ion concentration (GO:0051481)4.67291097
14left/right axis specification (GO:0070986)4.48712589
15protein localization to cilium (GO:0061512)4.24015170
16presynaptic membrane assembly (GO:0097105)3.86593364
17cellular component assembly involved in morphogenesis (GO:0010927)3.73992542
18postsynaptic membrane organization (GO:0001941)3.73917739
19auditory behavior (GO:0031223)3.67770753
20nonmotile primary cilium assembly (GO:0035058)3.67292018
21microtubule bundle formation (GO:0001578)3.65845324
22behavioral response to ethanol (GO:0048149)3.48188654
23regulation of microtubule-based movement (GO:0060632)3.47889136
24photoreceptor cell maintenance (GO:0045494)3.43713294
25transmission of nerve impulse (GO:0019226)3.38849302
26microtubule-based movement (GO:0007018)3.35690929
27mechanosensory behavior (GO:0007638)3.24388864
28cell projection assembly (GO:0030031)3.21544682
29protein polyglutamylation (GO:0018095)3.18669236
30sperm motility (GO:0030317)3.18544430
31presynaptic membrane organization (GO:0097090)3.16451816
32smoothened signaling pathway (GO:0007224)3.09638514
33regulation of synapse structural plasticity (GO:0051823)3.05192727
34vocalization behavior (GO:0071625)2.99020542
35negative regulation of transcription regulatory region DNA binding (GO:2000678)2.96537726
36one-carbon compound transport (GO:0019755)2.96149447
37response to auditory stimulus (GO:0010996)2.95912748
38negative regulation of axon guidance (GO:1902668)2.94764550
39determination of left/right symmetry (GO:0007368)2.90756974
40pyrimidine dimer repair (GO:0006290)2.88477167
41C4-dicarboxylate transport (GO:0015740)2.86948560
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86352800
43establishment of planar polarity (GO:0001736)2.86117344
44establishment of tissue polarity (GO:0007164)2.86117344
45vitamin transmembrane transport (GO:0035461)2.84049933
46determination of bilateral symmetry (GO:0009855)2.79855803
47retinal ganglion cell axon guidance (GO:0031290)2.75417861
48neuron cell-cell adhesion (GO:0007158)2.74703177
49negative regulation of protein localization to cell surface (GO:2000009)2.74113424
50behavioral response to nicotine (GO:0035095)2.72845812
51axon ensheathment in central nervous system (GO:0032291)2.72233806
52central nervous system myelination (GO:0022010)2.72233806
53retinal cone cell development (GO:0046549)2.72007518
54specification of symmetry (GO:0009799)2.71783274
55nucleoside diphosphate phosphorylation (GO:0006165)2.71312068
56regulation of feeding behavior (GO:0060259)2.70580351
57centriole assembly (GO:0098534)2.66921282
58cellular response to sterol (GO:0036315)2.66677330
59pyrimidine-containing compound transmembrane transport (GO:0072531)2.66656110
60limb development (GO:0060173)2.64951341
61appendage development (GO:0048736)2.64951341
62negative regulation of inclusion body assembly (GO:0090084)2.62304790
63positive regulation of mitochondrial fission (GO:0090141)2.59379232
64neuron projection extension involved in neuron projection guidance (GO:1902284)2.58784669
65axon extension involved in axon guidance (GO:0048846)2.58784669
66pyrimidine nucleobase catabolic process (GO:0006208)2.57595045
67eye photoreceptor cell differentiation (GO:0001754)2.56566642
68photoreceptor cell differentiation (GO:0046530)2.56566642
69neural tube formation (GO:0001841)2.55232006
70glomerular epithelial cell development (GO:0072310)2.53185463
71cornea development in camera-type eye (GO:0061303)2.52279155
72negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.51490275
73establishment of nucleus localization (GO:0040023)2.51328333
74microtubule polymerization or depolymerization (GO:0031109)2.51260704
75centriole replication (GO:0007099)2.49301032
76neurotransmitter-gated ion channel clustering (GO:0072578)2.48565608
77microtubule severing (GO:0051013)2.47749722
78protein localization to synapse (GO:0035418)2.45269521
79dendritic spine morphogenesis (GO:0060997)2.42209046
80lateral ventricle development (GO:0021670)2.41583067
81positive regulation of oligodendrocyte differentiation (GO:0048714)2.39403068
82neuronal action potential (GO:0019228)2.36941178
83gamma-aminobutyric acid transport (GO:0015812)2.36235550
84regulation of collateral sprouting (GO:0048670)2.34971478
85negative regulation of adenylate cyclase activity (GO:0007194)2.34712969
86telencephalon development (GO:0021537)2.34474684
87regulation of inclusion body assembly (GO:0090083)2.34264176
88regulation of protein glycosylation (GO:0060049)2.33440980
89retinal rod cell development (GO:0046548)2.33175971
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.32451583
91microtubule depolymerization (GO:0007019)2.31583266
92detection of light stimulus involved in sensory perception (GO:0050962)2.30619746
93detection of light stimulus involved in visual perception (GO:0050908)2.30619746
94cellular response to cholesterol (GO:0071397)2.30523346
95multicellular organism reproduction (GO:0032504)2.29476294
96neurotransmitter uptake (GO:0001504)2.28939377
97cytoplasmic microtubule organization (GO:0031122)2.28635961
98neurotransmitter catabolic process (GO:0042135)2.26604585
99cilium or flagellum-dependent cell motility (GO:0001539)11.1697563
100axonemal dynein complex assembly (GO:0070286)11.0078253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.54529694
2GBX2_23144817_ChIP-Seq_PC3_Human2.91630012
3CTBP2_25329375_ChIP-Seq_LNCAP_Human2.63276567
4ZNF274_21170338_ChIP-Seq_K562_Hela2.55006217
5VDR_22108803_ChIP-Seq_LS180_Human2.45524009
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39539856
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37547688
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37109392
9IGF1R_20145208_ChIP-Seq_DFB_Human2.36334923
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29792843
11* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15248029
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09766139
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07842188
14TAF15_26573619_Chip-Seq_HEK293_Human2.04078900
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.04074584
16AR_21572438_ChIP-Seq_LNCaP_Human2.01661718
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88304145
18NR3C1_21868756_ChIP-Seq_MCF10A_Human1.85018297
19DROSHA_22980978_ChIP-Seq_HELA_Human1.81868468
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.80787605
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80787605
22* P300_19829295_ChIP-Seq_ESCs_Human1.80102613
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78627164
24FUS_26573619_Chip-Seq_HEK293_Human1.78162895
25* SMAD4_21799915_ChIP-Seq_A2780_Human1.77951053
26TOP2B_26459242_ChIP-Seq_MCF-7_Human1.75754649
27* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75263163
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73211843
29* STAT3_23295773_ChIP-Seq_U87_Human1.69882649
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64841314
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63068786
32CBP_20019798_ChIP-Seq_JUKART_Human1.63068786
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61018217
34AR_25329375_ChIP-Seq_VCAP_Human1.60867201
35EWS_26573619_Chip-Seq_HEK293_Human1.59884686
36CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59839398
37* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57106667
38* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52756774
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.51403920
40REST_21632747_ChIP-Seq_MESCs_Mouse1.50770819
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48565503
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46695247
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45718032
44* ER_23166858_ChIP-Seq_MCF-7_Human1.41508054
45TP53_18474530_ChIP-ChIP_U2OS_Human1.40963029
46BCAT_22108803_ChIP-Seq_LS180_Human1.40912719
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40415903
48TCF4_23295773_ChIP-Seq_U87_Human1.40230304
49RUNX2_22187159_ChIP-Seq_PCA_Human1.38604018
50TCF4_22108803_ChIP-Seq_LS180_Human1.37602513
51TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36740229
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36273044
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34231345
54RXR_22108803_ChIP-Seq_LS180_Human1.33612443
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.32864329
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.32578517
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.30863402
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30701092
59AHR_22903824_ChIP-Seq_MCF-7_Human1.28832761
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26561820
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26388561
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.22761772
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21926602
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21075869
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19783171
66TP53_16413492_ChIP-PET_HCT116_Human1.19340479
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19001654
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.16661137
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16084544
70* RNF2_27304074_Chip-Seq_NSC_Mouse1.15953240
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15612965
72NANOG_19829295_ChIP-Seq_ESCs_Human1.13930163
73SOX2_19829295_ChIP-Seq_ESCs_Human1.13930163
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.13866110
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13545476
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.13523456
77* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12574247
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.09502954
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08351975
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07145759
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06591293
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05388013
83JUN_21703547_ChIP-Seq_K562_Human1.04387632
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04211373
85* SMAD4_21741376_ChIP-Seq_HESCs_Human1.02464900
86* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02368177
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02158680
88* SMAD3_21741376_ChIP-Seq_HESCs_Human1.01991892
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.01860269
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.01452500
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.01144022
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98550201
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98271248
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96666115
95GATA1_26923725_Chip-Seq_HPCs_Mouse0.96090634
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95972905
97CDX2_22108803_ChIP-Seq_LS180_Human0.95628970
98* AR_19668381_ChIP-Seq_PC3_Human0.95528483
99IRF1_19129219_ChIP-ChIP_H3396_Human0.94076268
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.94071237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.16598909
2MP0002653_abnormal_ependyma_morphology4.99433029
3MP0001984_abnormal_olfaction3.26178691
4MP0003880_abnormal_central_pattern3.24049589
5MP0008789_abnormal_olfactory_epithelium2.41183622
6MP0004133_heterotaxia2.23974681
7MP0005551_abnormal_eye_electrophysiolog2.23561413
8MP0001485_abnormal_pinna_reflex2.19615242
9MP0005394_taste/olfaction_phenotype2.16901366
10MP0005499_abnormal_olfactory_system2.16901366
11MP0008875_abnormal_xenobiotic_pharmacok2.07360010
12MP0001968_abnormal_touch/_nociception2.05343670
13MP0006276_abnormal_autonomic_nervous2.01597875
14MP0002638_abnormal_pupillary_reflex1.97883069
15MP0001529_abnormal_vocalization1.89759640
16MP0000383_abnormal_hair_follicle1.85693884
17MP0009780_abnormal_chondrocyte_physiolo1.81552070
18MP0000778_abnormal_nervous_system1.80298093
19MP0002102_abnormal_ear_morphology1.78230838
20MP0001486_abnormal_startle_reflex1.72662061
21MP0005253_abnormal_eye_physiology1.72053925
22MP0002734_abnormal_mechanical_nocicepti1.71444534
23MP0009046_muscle_twitch1.67570843
24MP0009745_abnormal_behavioral_response1.65776823
25MP0005423_abnormal_somatic_nervous1.65544396
26MP0002736_abnormal_nociception_after1.64695551
27MP0002822_catalepsy1.63475490
28MP0002876_abnormal_thyroid_physiology1.62164048
29MP0004043_abnormal_pH_regulation1.54785905
30MP0002282_abnormal_trachea_morphology1.48714945
31MP0000427_abnormal_hair_cycle1.46709292
32MP0002572_abnormal_emotion/affect_behav1.43929993
33MP0010678_abnormal_skin_adnexa1.43296873
34MP0000647_abnormal_sebaceous_gland1.42891644
35MP0002928_abnormal_bile_duct1.41847068
36MP0005623_abnormal_meninges_morphology1.39676431
37MP0002160_abnormal_reproductive_system1.36627847
38MP0001970_abnormal_pain_threshold1.35150611
39MP0003635_abnormal_synaptic_transmissio1.34905176
40MP0002272_abnormal_nervous_system1.31721692
41MP0005171_absent_coat_pigmentation1.30314888
42MP0005646_abnormal_pituitary_gland1.29054988
43MP0000566_synostosis1.28211007
44MP0004270_analgesia1.27503589
45MP0006072_abnormal_retinal_apoptosis1.26735786
46MP0000026_abnormal_inner_ear1.25985279
47MP0002064_seizures1.25630286
48MP0002557_abnormal_social/conspecific_i1.23256026
49MP0005195_abnormal_posterior_eye1.21920754
50MP0000955_abnormal_spinal_cord1.20947787
51MP0004859_abnormal_synaptic_plasticity1.19329335
52MP0002067_abnormal_sensory_capabilities1.19196699
53MP0002063_abnormal_learning/memory/cond1.16908032
54MP0000631_abnormal_neuroendocrine_gland1.16831678
55MP0004142_abnormal_muscle_tone1.16047385
56MP0001963_abnormal_hearing_physiology1.14381381
57MP0003011_delayed_dark_adaptation1.14113988
58MP0002752_abnormal_somatic_nervous1.08296644
59MP0003633_abnormal_nervous_system1.07029359
60MP0002735_abnormal_chemical_nociception1.05835449
61MP0002733_abnormal_thermal_nociception1.03282772
62MP0005391_vision/eye_phenotype1.03192093
63MP0005187_abnormal_penis_morphology1.03107351
64MP0004019_abnormal_vitamin_homeostasis1.03068100
65MP0002882_abnormal_neuron_morphology1.01999587
66MP0002229_neurodegeneration1.01635476
67MP0005410_abnormal_fertilization1.01200445
68MP0001501_abnormal_sleep_pattern1.00699996
69MP0002938_white_spotting0.99917212
70MP0003698_abnormal_male_reproductive0.98873027
71MP0008004_abnormal_stomach_pH0.98123403
72MP0002909_abnormal_adrenal_gland0.97642909
73MP0000569_abnormal_digit_pigmentation0.97401879
74MP0001986_abnormal_taste_sensitivity0.96142306
75MP0001293_anophthalmia0.94744647
76MP0002095_abnormal_skin_pigmentation0.93953588
77MP0000049_abnormal_middle_ear0.88978394
78MP0004885_abnormal_endolymph0.88281036
79MP0002132_abnormal_respiratory_system0.87704019
80MP0001502_abnormal_circadian_rhythm0.87456995
81MP0001324_abnormal_eye_pigmentation0.87234103
82MP0002152_abnormal_brain_morphology0.87124478
83MP0003890_abnormal_embryonic-extraembry0.85320483
84MP0005085_abnormal_gallbladder_physiolo0.83789385
85MP0001929_abnormal_gametogenesis0.83556262
86MP0002233_abnormal_nose_morphology0.83465913
87MP0008872_abnormal_physiological_respon0.82062014
88MP0002254_reproductive_system_inflammat0.81503251
89MP0002249_abnormal_larynx_morphology0.80725415
90MP0003937_abnormal_limbs/digits/tail_de0.80355686
91MP0003878_abnormal_ear_physiology0.79263362
92MP0005377_hearing/vestibular/ear_phenot0.79263362
93MP0003861_abnormal_nervous_system0.78720766
94MP0004085_abnormal_heartbeat0.78463279
95MP0008995_early_reproductive_senescence0.78267280
96MP0001664_abnormal_digestion0.77872322
97MP0002751_abnormal_autonomic_nervous0.77267562
98MP0005389_reproductive_system_phenotype0.75087602
99MP0005386_behavior/neurological_phenoty0.74014363
100MP0004924_abnormal_behavior0.74014363

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.64006022
2Abnormal ciliary motility (HP:0012262)8.22960267
3Abnormal respiratory epithelium morphology (HP:0012253)8.11061634
4Abnormal respiratory motile cilium morphology (HP:0005938)8.11061634
5Abnormal respiratory motile cilium physiology (HP:0012261)8.00800117
6Absent/shortened dynein arms (HP:0200106)7.90581129
7Dynein arm defect of respiratory motile cilia (HP:0012255)7.90581129
8Rhinitis (HP:0012384)6.80674823
9True hermaphroditism (HP:0010459)5.03661251
10Pancreatic fibrosis (HP:0100732)4.75956685
11Chronic bronchitis (HP:0004469)4.61960719
12Bronchiectasis (HP:0002110)4.56843050
13Occipital encephalocele (HP:0002085)4.19106148
14Pancreatic cysts (HP:0001737)4.12221456
15Nasal polyposis (HP:0100582)3.63838031
16Abnormality of midbrain morphology (HP:0002418)3.62294166
17Molar tooth sign on MRI (HP:0002419)3.62294166
18Nephronophthisis (HP:0000090)3.56395677
19Cystic liver disease (HP:0006706)3.50235053
20Medial flaring of the eyebrow (HP:0010747)3.48645671
21Gait imbalance (HP:0002141)3.39296845
22Chronic hepatic failure (HP:0100626)3.36974185
23Congenital primary aphakia (HP:0007707)3.31601781
24Postaxial foot polydactyly (HP:0001830)3.15119721
25Abnormality of the renal medulla (HP:0100957)3.06381403
26Tubulointerstitial nephritis (HP:0001970)3.02004628
27Aplasia/Hypoplasia of the tongue (HP:0010295)3.00905131
28Nephrogenic diabetes insipidus (HP:0009806)2.96797546
29Infertility (HP:0000789)2.95809550
30Sclerocornea (HP:0000647)2.92305028
31Abnormality of the nasal mucosa (HP:0000433)2.80097566
32Anencephaly (HP:0002323)2.70256262
33Chronic sinusitis (HP:0011109)2.63642850
34Thyroid-stimulating hormone excess (HP:0002925)2.62264362
35Tubular atrophy (HP:0000092)2.59238331
36Congenital hepatic fibrosis (HP:0002612)2.56557372
37Genital tract atresia (HP:0001827)2.52742582
38Male pseudohermaphroditism (HP:0000037)2.51928069
39Vaginal atresia (HP:0000148)2.45223803
40Recurrent sinusitis (HP:0011108)2.38282969
41Bony spicule pigmentary retinopathy (HP:0007737)2.37440762
42Poor coordination (HP:0002370)2.35751784
43Furrowed tongue (HP:0000221)2.34425565
44Male infertility (HP:0003251)2.30803348
45Concave nail (HP:0001598)2.29738655
46Postaxial hand polydactyly (HP:0001162)2.27138852
47Retinal dysplasia (HP:0007973)2.19536459
48Large for gestational age (HP:0001520)2.16409364
49Hemiparesis (HP:0001269)2.14574344
50Bronchitis (HP:0012387)2.11263644
51Type II lissencephaly (HP:0007260)2.11221397
52Abnormality of macular pigmentation (HP:0008002)2.08466334
53Preaxial hand polydactyly (HP:0001177)2.04274475
54Abnormal biliary tract physiology (HP:0012439)2.01203595
55Bile duct proliferation (HP:0001408)2.01203595
56Tubulointerstitial abnormality (HP:0001969)2.00806242
57Hyperventilation (HP:0002883)2.00623133
58Abnormal drinking behavior (HP:0030082)2.00002860
59Polydipsia (HP:0001959)2.00002860
60Specific learning disability (HP:0001328)1.99233412
61Broad foot (HP:0001769)1.97489281
62Oculomotor apraxia (HP:0000657)1.97348454
63Recurrent otitis media (HP:0000403)1.89443713
64Aplasia/Hypoplasia of the tibia (HP:0005772)1.86248403
65Abnormal rod and cone electroretinograms (HP:0008323)1.85002349
66Aplasia/Hypoplasia of the lens (HP:0008063)1.81940986
67Attenuation of retinal blood vessels (HP:0007843)1.80269302
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80156460
69Progressive cerebellar ataxia (HP:0002073)1.80058559
70Abnormality of the renal cortex (HP:0011035)1.79371406
71Focal motor seizures (HP:0011153)1.78910825
72Retinitis pigmentosa (HP:0000510)1.78645970
73Decreased central vision (HP:0007663)1.77975806
74Absent speech (HP:0001344)1.76318141
75Median cleft lip (HP:0000161)1.75643805
76Cerebellar dysplasia (HP:0007033)1.69084674
77Aganglionic megacolon (HP:0002251)1.67971387
78Polyphagia (HP:0002591)1.61674565
79Supernumerary spleens (HP:0009799)1.61545924
80Abnormality of the dental pulp (HP:0006479)1.61033795
81Renal dysplasia (HP:0000110)1.60486894
82Narrow forehead (HP:0000341)1.60429389
83Gaze-evoked nystagmus (HP:0000640)1.59516443
84Stage 5 chronic kidney disease (HP:0003774)1.58502507
85Focal seizures (HP:0007359)1.58217075
86Left ventricular hypertrophy (HP:0001712)1.55826230
87Prominent nasal bridge (HP:0000426)1.52934858
88Decreased circulating renin level (HP:0003351)1.52487403
89Oligodactyly (hands) (HP:0001180)1.50146946
90Fibular hypoplasia (HP:0003038)1.48194112
91Abnormality of permanent molar morphology (HP:0011071)1.47974509
92Abnormality of the dental root (HP:0006486)1.47974509
93Taurodontia (HP:0000679)1.47974509
94Chorioretinal atrophy (HP:0000533)1.47232195
95Broad-based gait (HP:0002136)1.47076639
96Atonic seizures (HP:0010819)1.45233455
97Nephropathy (HP:0000112)1.44347276
98Abolished electroretinogram (ERG) (HP:0000550)1.43578898
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.42684975
100Abnormality of the aortic arch (HP:0012303)1.40648798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.33065622
2FRK4.54092577
3PNCK3.56773619
4CASK3.35555337
5PINK12.88277723
6ADRBK22.70860965
7BMPR1B2.23635337
8TSSK62.15891631
9EPHA32.15714384
10WEE12.09492124
11BCR1.94706676
12NTRK31.92575284
13NTRK21.91404824
14MARK11.77524350
15MAPK131.72379515
16MAP3K41.62365903
17MAP4K21.62047359
18MST41.60095527
19INSRR1.59242896
20EPHB11.55231360
21MAP2K71.50783409
22WNK31.49723579
23STK391.45712835
24WNK41.33837933
25CAMKK21.28344916
26EPHA21.28190323
27CSNK1A1L1.22761242
28ADRBK11.21084399
29DYRK31.19785025
30TYRO31.15244991
31CSNK1G21.11922271
32STK38L1.10727368
33OXSR11.09698048
34CSNK1G31.06962168
35CDK191.04900040
36CSNK1G11.04114512
37ERBB20.99062616
38EPHA40.97844117
39PRKCE0.97151763
40DYRK20.95463042
41MAPKAPK30.95425301
42GRK70.92436905
43PTK2B0.90105559
44NEK60.86291470
45TGFBR10.84579599
46IRAK10.80356367
47ERBB30.80111078
48PLK20.78911256
49GRK10.76642835
50PRKCG0.76580873
51CAMK1D0.75045710
52CAMK2A0.74180128
53SGK4940.73718579
54SGK2230.73718579
55NME10.70646583
56CDK80.68620562
57MAP3K20.67382706
58PKN10.65310968
59PBK0.64400713
60PAK30.64268416
61MET0.64259454
62PDK20.60133263
63FGFR20.59096978
64STK380.58101955
65TRIM280.57716733
66FER0.55045687
67NEK90.53799213
68CDK30.53444859
69AKT30.51787884
70CAMK1G0.48870516
71PRKACA0.47429104
72MAPKAPK50.47418089
73MAP2K40.47360054
74MKNK20.46049767
75CAMK40.44011259
76RPS6KA50.41106676
77SGK20.40259786
78CAMKK10.39230106
79CAMK2G0.37863908
80LATS10.37838206
81DYRK1B0.35727236
82DYRK1A0.35386902
83RPS6KA40.34932654
84EPHB20.34396896
85CSNK1A10.33554853
86CDK50.33191065
87PRKG10.32751992
88PIK3CA0.32669185
89ACVR1B0.32421521
90UHMK10.32005005
91PRKD30.31115383
92PRKCI0.29196913
93PRKCA0.28639386
94CAMK2B0.28431973
95VRK10.28089227
96SGK10.28035415
97ABL10.27241937
98TNIK0.25924934
99RET0.25821680
100PLK40.25335261

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.24662735
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68719849
3Nicotine addiction_Homo sapiens_hsa050332.63831241
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.41892020
5Butanoate metabolism_Homo sapiens_hsa006502.41223303
6ABC transporters_Homo sapiens_hsa020102.26868493
7Taste transduction_Homo sapiens_hsa047422.24575930
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18566876
9Chemical carcinogenesis_Homo sapiens_hsa052042.09449619
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04537620
11Phototransduction_Homo sapiens_hsa047442.03323012
12Olfactory transduction_Homo sapiens_hsa047401.96959001
13Morphine addiction_Homo sapiens_hsa050321.91038059
14Histidine metabolism_Homo sapiens_hsa003401.89782576
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85497367
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77014286
17Nitrogen metabolism_Homo sapiens_hsa009101.73741614
18GABAergic synapse_Homo sapiens_hsa047271.71484199
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69905432
20Huntingtons disease_Homo sapiens_hsa050161.69861249
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.58969437
22beta-Alanine metabolism_Homo sapiens_hsa004101.56427588
23Steroid biosynthesis_Homo sapiens_hsa001001.55258957
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54682174
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53140612
26Linoleic acid metabolism_Homo sapiens_hsa005911.50038660
27Glutamatergic synapse_Homo sapiens_hsa047241.49828029
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47611768
29Circadian entrainment_Homo sapiens_hsa047131.43601415
30Cocaine addiction_Homo sapiens_hsa050301.40768457
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40269343
32Peroxisome_Homo sapiens_hsa041461.32427779
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.32194738
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20514608
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18940645
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17332685
37Tryptophan metabolism_Homo sapiens_hsa003801.15390933
38Retinol metabolism_Homo sapiens_hsa008301.14029111
39Glutathione metabolism_Homo sapiens_hsa004801.12805019
40Axon guidance_Homo sapiens_hsa043601.11921532
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10171905
42PPAR signaling pathway_Homo sapiens_hsa033201.08307263
43Phenylalanine metabolism_Homo sapiens_hsa003601.08044564
44Hedgehog signaling pathway_Homo sapiens_hsa043401.05514244
45Caffeine metabolism_Homo sapiens_hsa002321.05179648
46Fatty acid biosynthesis_Homo sapiens_hsa000611.04620041
47Serotonergic synapse_Homo sapiens_hsa047261.04014093
48Propanoate metabolism_Homo sapiens_hsa006401.02812554
49Salivary secretion_Homo sapiens_hsa049701.01601049
50Fatty acid degradation_Homo sapiens_hsa000710.97698883
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93930489
52Fatty acid metabolism_Homo sapiens_hsa012120.92978011
53Dopaminergic synapse_Homo sapiens_hsa047280.92765611
54Gastric acid secretion_Homo sapiens_hsa049710.92557911
55Tyrosine metabolism_Homo sapiens_hsa003500.90687497
56Fanconi anemia pathway_Homo sapiens_hsa034600.88302789
57Estrogen signaling pathway_Homo sapiens_hsa049150.85616925
58Calcium signaling pathway_Homo sapiens_hsa040200.84402109
59Basal cell carcinoma_Homo sapiens_hsa052170.84389249
60Fatty acid elongation_Homo sapiens_hsa000620.84139423
61cAMP signaling pathway_Homo sapiens_hsa040240.84026717
62Sphingolipid metabolism_Homo sapiens_hsa006000.83476093
63Collecting duct acid secretion_Homo sapiens_hsa049660.81450569
64Cholinergic synapse_Homo sapiens_hsa047250.79518105
65Amphetamine addiction_Homo sapiens_hsa050310.79254443
66Insulin secretion_Homo sapiens_hsa049110.78553901
67Ovarian steroidogenesis_Homo sapiens_hsa049130.72228554
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71274637
69Regulation of autophagy_Homo sapiens_hsa041400.68984343
70Protein export_Homo sapiens_hsa030600.68227257
71Hippo signaling pathway_Homo sapiens_hsa043900.67987750
72Dorso-ventral axis formation_Homo sapiens_hsa043200.67786172
73Arginine and proline metabolism_Homo sapiens_hsa003300.64967087
74Gap junction_Homo sapiens_hsa045400.64207264
75Sulfur relay system_Homo sapiens_hsa041220.62789230
76Glycerolipid metabolism_Homo sapiens_hsa005610.62077652
77Arachidonic acid metabolism_Homo sapiens_hsa005900.59608155
78Circadian rhythm_Homo sapiens_hsa047100.58077843
79Oxidative phosphorylation_Homo sapiens_hsa001900.54788256
80Bile secretion_Homo sapiens_hsa049760.51561450
81Oxytocin signaling pathway_Homo sapiens_hsa049210.51502423
82Metabolic pathways_Homo sapiens_hsa011000.50420013
83Basal transcription factors_Homo sapiens_hsa030220.49911545
84Parkinsons disease_Homo sapiens_hsa050120.49547835
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49044338
86Long-term depression_Homo sapiens_hsa047300.47334489
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44718395
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44270781
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.43437826
90Tight junction_Homo sapiens_hsa045300.43284992
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43069402
92Cardiac muscle contraction_Homo sapiens_hsa042600.42120298
93Synaptic vesicle cycle_Homo sapiens_hsa047210.40603942
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.38065701
95RNA polymerase_Homo sapiens_hsa030200.37141729
96Ether lipid metabolism_Homo sapiens_hsa005650.36810675
97Notch signaling pathway_Homo sapiens_hsa043300.35939278
98Melanogenesis_Homo sapiens_hsa049160.33261414
99Alcoholism_Homo sapiens_hsa050340.33234932
100Renin secretion_Homo sapiens_hsa049240.31318740

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