ANKFY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternate splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.78917379
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.78917379
3modulation by symbiont of host immune response (GO:0052553)4.78917379
4positive regulation by symbiont of host defense response (GO:0052509)4.78917379
5modulation by symbiont of host defense response (GO:0052031)4.78917379
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.78917379
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44091140
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44091140
9regulation of interferon-beta biosynthetic process (GO:0045357)4.43069517
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.42656775
11antigen processing and presentation of endogenous antigen (GO:0019883)4.23200283
12positive regulation of interferon-alpha production (GO:0032727)3.97995374
13positive regulation of gamma-delta T cell activation (GO:0046645)3.88352068
14regulation of interferon-alpha production (GO:0032647)3.74897057
15regulation of NFAT protein import into nucleus (GO:0051532)3.64825942
16dermatan sulfate biosynthetic process (GO:0030208)3.50349151
17regulation of interleukin-12 biosynthetic process (GO:0045075)3.47988975
18macrophage activation involved in immune response (GO:0002281)3.46860555
19dermatan sulfate metabolic process (GO:0030205)3.38199559
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.37920373
21nuclear pore complex assembly (GO:0051292)3.36153294
22establishment of nucleus localization (GO:0040023)3.16306716
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07381848
24response to host immune response (GO:0052572)3.07381848
25semaphorin-plexin signaling pathway (GO:0071526)3.02605461
26nuclear pore organization (GO:0006999)3.02231746
27response to host (GO:0075136)3.01023708
28response to host defenses (GO:0052200)3.01023708
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01023708
30positive regulation of interferon-beta production (GO:0032728)2.95334513
31regulation of B cell receptor signaling pathway (GO:0050855)2.94452529
32I-kappaB phosphorylation (GO:0007252)2.90871822
33cell adhesion mediated by integrin (GO:0033627)2.90296323
34protein localization to endosome (GO:0036010)2.90201702
35astrocyte differentiation (GO:0048708)2.85333354
36pore complex assembly (GO:0046931)2.79907148
37immunoglobulin mediated immune response (GO:0016064)2.79302555
38regulation of chemokine-mediated signaling pathway (GO:0070099)2.79153493
39adherens junction assembly (GO:0034333)2.74312554
40histone H3-K36 demethylation (GO:0070544)2.72194515
41amino acid import (GO:0043090)2.71621936
42regulation of gamma-delta T cell differentiation (GO:0045586)2.70504481
43regulation of gamma-delta T cell activation (GO:0046643)2.69568948
44L-amino acid import (GO:0043092)2.68707867
45JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.67619927
46negative regulation of cell killing (GO:0031342)2.66092598
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66092598
48negative regulation of B cell proliferation (GO:0030889)2.63780606
49layer formation in cerebral cortex (GO:0021819)2.63402204
50negative regulation of myotube differentiation (GO:0010832)2.62089929
51pinocytosis (GO:0006907)2.60954604
52response to muramyl dipeptide (GO:0032495)2.60908175
53positive regulation of B cell differentiation (GO:0045579)2.60464035
54response to type I interferon (GO:0034340)2.58303829
55germ cell migration (GO:0008354)2.58115294
56cytoplasmic mRNA processing body assembly (GO:0033962)2.57218605
57neutrophil activation involved in immune response (GO:0002283)2.57082269
58positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56102591
59planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54941754
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54105689
61regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53835296
62morphogenesis of an epithelial sheet (GO:0002011)2.52064665
63positive regulation of histone deacetylation (GO:0031065)2.51363421
64camera-type eye morphogenesis (GO:0048593)2.50874294
65type I interferon signaling pathway (GO:0060337)2.50733221
66cellular response to type I interferon (GO:0071357)2.50733221
67cell-substrate adherens junction assembly (GO:0007045)2.50425120
68focal adhesion assembly (GO:0048041)2.50425120
69response to peptidoglycan (GO:0032494)2.49604779
70cellular response to interferon-alpha (GO:0035457)2.49474846
71mitotic sister chromatid cohesion (GO:0007064)2.49429175
72nerve growth factor signaling pathway (GO:0038180)2.49332511
73insulin-like growth factor receptor signaling pathway (GO:0048009)2.49105228
74neuron projection extension involved in neuron projection guidance (GO:1902284)2.48600428
75axon extension involved in axon guidance (GO:0048846)2.48600428
76growth hormone receptor signaling pathway (GO:0060396)2.47787956
77microglial cell activation (GO:0001774)2.46311930
78cell-substrate junction assembly (GO:0007044)2.46273501
79cortical actin cytoskeleton organization (GO:0030866)2.46258104
80hepatocyte apoptotic process (GO:0097284)2.45917039
81positive regulation of receptor recycling (GO:0001921)2.44532756
82regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44222276
83apoptotic cell clearance (GO:0043277)2.43499587
84positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.41950094
85tolerance induction (GO:0002507)2.41757848
86astrocyte development (GO:0014002)2.41752716
87B cell receptor signaling pathway (GO:0050853)2.39982246
88NLS-bearing protein import into nucleus (GO:0006607)2.39780691
89cortical cytoskeleton organization (GO:0030865)2.39515408
90negative regulation of neurotransmitter secretion (GO:0046929)2.39146131
91basement membrane organization (GO:0071711)2.38799718
92natural killer cell mediated immunity (GO:0002228)2.37635696
93natural killer cell mediated cytotoxicity (GO:0042267)2.37635696
94positive thymic T cell selection (GO:0045059)2.37337927
95skin morphogenesis (GO:0043589)2.35347997
96positive regulation of chemokine biosynthetic process (GO:0045080)2.35209025
97establishment of spindle orientation (GO:0051294)2.35063985
98regulation of interferon-beta production (GO:0032648)2.34821359
99phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.32718994
100Notch signaling involved in heart development (GO:0061314)2.32308205
101mannose metabolic process (GO:0006013)2.32139665
102macrophage activation (GO:0042116)2.31757457
103negative regulation of phagocytosis (GO:0050765)2.30813987
104axonal fasciculation (GO:0007413)2.30259274
105response to interferon-alpha (GO:0035455)2.29743106
106epithelial cell differentiation involved in prostate gland development (GO:0060742)2.28785331
107response to laminar fluid shear stress (GO:0034616)2.28705183
108peptidyl-threonine modification (GO:0018210)2.28131881
109B cell mediated immunity (GO:0019724)2.27793938
110Arp2/3 complex-mediated actin nucleation (GO:0034314)2.27761101
111nucleus localization (GO:0051647)2.27426171
112positive regulation of SMAD protein import into nucleus (GO:0060391)2.27057914
113regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.27041461
114positive regulation of antigen processing and presentation (GO:0002579)2.26885747
115regulation of type I interferon-mediated signaling pathway (GO:0060338)2.26378144
116interferon-gamma-mediated signaling pathway (GO:0060333)2.26266504
117regulation of protein polyubiquitination (GO:1902914)2.25959078
118paraxial mesoderm development (GO:0048339)2.25957914
119negative regulation of erythrocyte differentiation (GO:0045647)2.25152241
120barbed-end actin filament capping (GO:0051016)2.25001394
121regulation of ARF protein signal transduction (GO:0032012)2.24771593
122regulation of ARF GTPase activity (GO:0032312)2.24635618
123cellular response to catecholamine stimulus (GO:0071870)2.24317477
124cellular response to monoamine stimulus (GO:0071868)2.24317477
125leukocyte aggregation (GO:0070486)2.24096827
126negative regulation of neurotransmitter transport (GO:0051589)2.23867831
127positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23842110
128embryonic camera-type eye morphogenesis (GO:0048596)2.23648954
129peptidyl-threonine phosphorylation (GO:0018107)2.23596486
130regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.22466685
131locomotory exploration behavior (GO:0035641)2.21860132
132B cell homeostasis (GO:0001782)2.21482798
133regulation of axon extension involved in axon guidance (GO:0048841)2.21424045
134pre-miRNA processing (GO:0031054)2.21197990
135negative regulation of granulocyte differentiation (GO:0030853)2.20706954
136positive regulation of axon extension (GO:0045773)2.18293350
137neutrophil activation (GO:0042119)2.18244919
138regulation of mitotic spindle organization (GO:0060236)2.17984725
139establishment of spindle localization (GO:0051293)2.17146098
140eye morphogenesis (GO:0048592)2.17092682
141import into cell (GO:0098657)2.16999144
142stress granule assembly (GO:0034063)2.16744964
143neuron projection regeneration (GO:0031102)2.16412475
144dosage compensation (GO:0007549)2.16199238
145chondroitin sulfate biosynthetic process (GO:0030206)2.16048496
146substrate-dependent cell migration (GO:0006929)2.15597517
147regulation of integrin activation (GO:0033623)2.15123822
148protein localization to kinetochore (GO:0034501)2.14663531
149regulation of B cell differentiation (GO:0045577)2.14479270
150peptidyl-lysine dimethylation (GO:0018027)2.13439006
151histone lysine demethylation (GO:0070076)2.13261263
152leukocyte cell-cell adhesion (GO:0007159)2.12454471
153germinal center formation (GO:0002467)2.12239011
154histone H3-K9 demethylation (GO:0033169)2.12014244
155myelination in peripheral nervous system (GO:0022011)2.11744089
156peripheral nervous system axon ensheathment (GO:0032292)2.11744089
157granulocyte activation (GO:0036230)2.10910840
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.10764036
159negative regulation of interleukin-12 production (GO:0032695)2.09915642
160myeloid cell activation involved in immune response (GO:0002275)2.09782312
161mitotic chromosome condensation (GO:0007076)2.09763205
162regulation of nucleobase-containing compound transport (GO:0032239)2.09743306
163axon extension (GO:0048675)2.08743089
164negative regulation of fatty acid transport (GO:2000192)2.08310415
165regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.07806653
166heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.07591573
167cellular response to growth hormone stimulus (GO:0071378)2.07434796
168spindle assembly involved in mitosis (GO:0090307)2.07355658
169positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.07080078
170regulation of antigen processing and presentation (GO:0002577)2.06918210
171histone demethylation (GO:0016577)2.06728768
172activation of protein kinase A activity (GO:0034199)2.04670133
173stress fiber assembly (GO:0043149)2.03849186
174regulation of glucose import in response to insulin stimulus (GO:2001273)2.02923065
175chondroitin sulfate catabolic process (GO:0030207)2.02522120
176regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.02180794
177neuron recognition (GO:0008038)2.00271652
178positive regulation of synaptic transmission, dopaminergic (GO:0032226)1.99550272
179neuron projection extension (GO:1990138)1.98950896
180histone H3-K4 trimethylation (GO:0080182)1.98716336
181dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.98352153
182negative regulation of vascular permeability (GO:0043116)1.97888827
183hemidesmosome assembly (GO:0031581)1.97198085
184cell-cell junction maintenance (GO:0045217)1.94984792
185Rac protein signal transduction (GO:0016601)1.93646376
186cell migration in hindbrain (GO:0021535)1.93605629
187regulation of axon guidance (GO:1902667)1.93589432
188vascular endothelial growth factor receptor signaling pathway (GO:0048010)1.91732154
189Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.91615591
190fibroblast migration (GO:0010761)1.91513733
191positive regulation of blood vessel endothelial cell migration (GO:0043536)1.91302430
192endocytic recycling (GO:0032456)1.90921205
193central nervous system projection neuron axonogenesis (GO:0021952)1.89713987
194response to monoamine (GO:0071867)1.89659506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.21589450
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.52766648
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.31295233
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03449701
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.95920303
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.94924867
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.83959976
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02590199
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.86522760
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74736255
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65857944
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65810713
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63886618
14* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63281527
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56306135
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51281740
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.47175902
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45585202
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38675786
20MYC_22102868_ChIP-Seq_BL_Human2.35258556
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.29905573
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21352436
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.17487172
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08866332
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06720465
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05596054
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04721719
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01704962
29KDM2B_26808549_Chip-Seq_K562_Human2.00828900
30VDR_21846776_ChIP-Seq_THP-1_Human1.98151972
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96663713
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.96407766
33* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.96244357
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95409490
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.90341502
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.85177878
37MAF_26560356_Chip-Seq_TH1_Human1.82250953
38MYB_26560356_Chip-Seq_TH2_Human1.79927129
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79463371
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75412167
41SCL_19346495_ChIP-Seq_HPC-7_Human1.73390002
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73117164
43* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71056525
44TCF7_22412390_ChIP-Seq_EML_Mouse1.67508637
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67365492
46RUNX_20019798_ChIP-Seq_JUKART_Human1.64495947
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.63859722
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63251310
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.62637525
50SPI1_23127762_ChIP-Seq_K562_Human1.62427876
51MYB_26560356_Chip-Seq_TH1_Human1.57550702
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55611407
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.55446548
54SPI1_23547873_ChIP-Seq_NB4_Human1.55332004
55* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55123835
56UTX_26944678_Chip-Seq_JUKART_Human1.54969973
57DROSHA_22980978_ChIP-Seq_HELA_Human1.54862922
58VDR_24763502_ChIP-Seq_THP-1_Human1.54566817
59GATA1_22025678_ChIP-Seq_K562_Human1.54389925
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.54091887
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48370551
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47313082
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46443032
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.42372836
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41071621
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39824688
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39797097
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39110096
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.37683600
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.35519881
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35420746
72PU_27001747_Chip-Seq_BMDM_Mouse1.35402447
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.34796835
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33977171
75KDM2B_26808549_Chip-Seq_DND41_Human1.31957303
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30915627
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30887369
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30887369
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30791051
80AR_21909140_ChIP-Seq_LNCAP_Human1.30168820
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29058391
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28292801
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27954949
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27954949
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27206926
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.26504315
87TFEB_21752829_ChIP-Seq_HELA_Human1.25931450
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.25774417
89CLOCK_20551151_ChIP-Seq_293T_Human1.25387215
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24444190
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24317929
92AHR_22903824_ChIP-Seq_MCF-7_Human1.22498808
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20524906
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17773818
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.17638024
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17564789
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17471910
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16523994
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15869890
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15696637
101BRD4_25478319_ChIP-Seq_HGPS_Human1.15695057
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.15602358
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15328677
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14051401
105TBX20_22328084_ChIP-Seq_HEART_Mouse1.13892167
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.13892167
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13579887
108GATA3_27048872_Chip-Seq_THYMUS_Human1.13377145
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12421214
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11915443
111LXR_22292898_ChIP-Seq_THP-1_Human1.11786809
112AR_21572438_ChIP-Seq_LNCaP_Human1.11090532
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09282085
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.07830856
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07481446
116TP53_16413492_ChIP-PET_HCT116_Human1.06991592
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06907517
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06899993
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06494349
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06032219
121* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05029641
122FOXA2_19822575_ChIP-Seq_HepG2_Human1.05002923
123VDR_24787735_ChIP-Seq_THP-1_Human1.04838547
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04670888
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04655799
126BP1_19119308_ChIP-ChIP_Hs578T_Human1.03281902
127GATA2_21666600_ChIP-Seq_HMVEC_Human1.03191182
128GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02357799
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01227871
130RING1B_27294783_Chip-Seq_NPCs_Mouse1.00757505
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00315614
132EP300_21415370_ChIP-Seq_HL-1_Mouse1.00244830
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99733109
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99628541
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99406862
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99254782
137RACK7_27058665_Chip-Seq_MCF-7_Human0.99039418
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98681270
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98656155
140UBF1/2_26484160_Chip-Seq_HMECs_Human0.98533867
141MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95189283
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95081223
143TP53_22127205_ChIP-Seq_IMR90_Human0.94995818
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.94812371
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94724540
146NCOR1_26117541_ChIP-Seq_K562_Human0.93979206
147* AR_19668381_ChIP-Seq_PC3_Human0.93900833
148UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93343614
149* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92977930
150SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92848292
151* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92595328
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91831905
153SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91643526
154GATA1_19941826_ChIP-Seq_K562_Human0.91417938
155TRIM28_21343339_ChIP-Seq_HEK293_Human0.91346495
156GATA6_25053715_ChIP-Seq_YYC3_Human0.90810611
157HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90407902
158CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89450826
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.89093441
160PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88632909
161RING1B_27294783_Chip-Seq_ESCs_Mouse0.88146781
162JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87507217
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.85813290
164STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85298677
165RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85172607
166* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83982495
167* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82487886
168* MAF_26560356_Chip-Seq_TH2_Human0.82422326
169CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82411784
170RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82137615
171KDM2B_26808549_Chip-Seq_JURKAT_Human0.81520182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color3.65026103
2MP0003300_gastrointestinal_ulcer3.14621694
3MP0000569_abnormal_digit_pigmentation3.08803482
4MP0001835_abnormal_antigen_presentation2.94656960
5MP0003303_peritoneal_inflammation2.91720147
6MP0003690_abnormal_glial_cell2.65909772
7MP0005076_abnormal_cell_differentiation2.55192402
8MP0003705_abnormal_hypodermis_morpholog2.53799266
9MP0010352_gastrointestinal_tract_polyps2.50916158
10MP0004858_abnormal_nervous_system2.49959643
11MP0010307_abnormal_tumor_latency2.39282671
12MP0003329_amyloid_beta_deposits2.37809984
13MP0003136_yellow_coat_color2.17238888
14MP0008260_abnormal_autophagy2.13230665
15MP0008438_abnormal_cutaneous_collagen2.07438613
16MP0002166_altered_tumor_susceptibility2.05080200
17MP0005623_abnormal_meninges_morphology2.04637468
18MP0003436_decreased_susceptibility_to2.02889356
19MP0004859_abnormal_synaptic_plasticity1.95197274
20MP0000778_abnormal_nervous_system1.93317538
21MP0003566_abnormal_cell_adhesion1.92839295
22MP0002452_abnormal_antigen_presenting1.91416406
23MP0000685_abnormal_immune_system1.91211871
24MP0005058_abnormal_lysosome_morphology1.88580330
25MP0001800_abnormal_humoral_immune1.88249155
26MP0001790_abnormal_immune_system1.85722667
27MP0005387_immune_system_phenotype1.85722667
28MP0002419_abnormal_innate_immunity1.85562500
29MP0003634_abnormal_glial_cell1.80865587
30MP0009278_abnormal_bone_marrow1.77372394
31MP0003172_abnormal_lysosome_physiology1.76393674
32MP0005000_abnormal_immune_tolerance1.75137510
33MP0004947_skin_inflammation1.74707557
34MP0004808_abnormal_hematopoietic_stem1.74148347
35MP0002396_abnormal_hematopoietic_system1.72538866
36MP0002006_tumorigenesis1.65746619
37MP0005671_abnormal_response_to1.61282288
38MP0002723_abnormal_immune_serum1.59686036
39MP0003448_altered_tumor_morphology1.58256431
40MP0001819_abnormal_immune_cell1.57378855
41MP0002420_abnormal_adaptive_immunity1.57029985
42MP0005464_abnormal_platelet_physiology1.53510915
43MP0005025_abnormal_response_to1.52949422
44MP0005023_abnormal_wound_healing1.50566158
45MP0006082_CNS_inflammation1.49506913
46MP0004381_abnormal_hair_follicle1.47860068
47MP0003091_abnormal_cell_migration1.47725222
48MP0002398_abnormal_bone_marrow1.46197177
49MP0001958_emphysema1.44215117
50MP0006054_spinal_hemorrhage1.39590970
51MP0009785_altered_susceptibility_to1.37910595
52MP0005171_absent_coat_pigmentation1.37571612
53MP0010368_abnormal_lymphatic_system1.37104517
54MP0010155_abnormal_intestine_physiology1.33189470
55MP0002405_respiratory_system_inflammati1.31764420
56MP0001873_stomach_inflammation1.31687696
57MP0000716_abnormal_immune_system1.31369587
58MP0000920_abnormal_myelination1.31174624
59MP0004272_abnormal_basement_membrane1.29340033
60MP0001533_abnormal_skeleton_physiology1.28609039
61MP0003115_abnormal_respiratory_system1.27791108
62MP0001545_abnormal_hematopoietic_system1.27494265
63MP0005397_hematopoietic_system_phenotyp1.27494265
64MP0004130_abnormal_muscle_cell1.27320839
65MP0001915_intracranial_hemorrhage1.26937704
66MP0000689_abnormal_spleen_morphology1.25316619
67MP0004233_abnormal_muscle_weight1.25226567
68MP0000858_altered_metastatic_potential1.24554338
69MP0000733_abnormal_muscle_development1.24152271
70MP0003632_abnormal_nervous_system1.23352602
71MP0001299_abnormal_eye_distance/1.23327023
72MP0001348_abnormal_lacrimal_gland1.23109003
73MP0000465_gastrointestinal_hemorrhage1.21694577
74MP0005503_abnormal_tendon_morphology1.20913317
75MP0000604_amyloidosis1.19632343
76MP0002722_abnormal_immune_system1.19181494
77MP0005248_abnormal_Harderian_gland1.17109938
78MP0003111_abnormal_nucleus_morphology1.16500904
79MP0002877_abnormal_melanocyte_morpholog1.16308526
80MP0002429_abnormal_blood_cell1.15008079
81MP0002148_abnormal_hypersensitivity_rea1.14035901
82MP0003045_fibrosis1.13796901
83MP0002896_abnormal_bone_mineralization1.13728418
84MP0001845_abnormal_inflammatory_respons1.13064135
85MP0002009_preneoplasia1.12172065
86MP0000534_abnormal_ureter_morphology1.11981040
87MP0000371_diluted_coat_color1.11740492
88MP0003279_aneurysm1.09897255
89MP0002092_abnormal_eye_morphology1.09832206
90MP0005257_abnormal_intraocular_pressure1.09443661
91MP0004270_analgesia1.09102436
92MP0003077_abnormal_cell_cycle1.08027474
93MP0001853_heart_inflammation1.07506970
94MP0000015_abnormal_ear_pigmentation1.07484740
95MP0000428_abnormal_craniofacial_morphol1.05871846
96MP0000703_abnormal_thymus_morphology1.05651487
97MP0003453_abnormal_keratinocyte_physiol1.05325105
98MP0004510_myositis1.03253930
99MP0000490_abnormal_crypts_of1.02988305
100MP0002909_abnormal_adrenal_gland1.02635835
101MP0001502_abnormal_circadian_rhythm1.02610764
102MP0002933_joint_inflammation1.00683371
103MP0000767_abnormal_smooth_muscle1.00587263
104MP0000350_abnormal_cell_proliferation1.00066276
105MP0004811_abnormal_neuron_physiology0.99443010
106MP0000579_abnormal_nail_morphology0.99348232
107MP0003942_abnormal_urinary_system0.98537411
108MP0003183_abnormal_peptide_metabolism0.98406417
109MP0003763_abnormal_thymus_physiology0.97392549
110MP0009333_abnormal_splenocyte_physiolog0.96855164
111MP0008007_abnormal_cellular_replicative0.96786590
112MP0004197_abnormal_fetal_growth/weight/0.96543855
113MP0010094_abnormal_chromosome_stability0.95492503
114MP0005388_respiratory_system_phenotype0.95413598
115MP0002133_abnormal_respiratory_system0.95413598
116MP0002998_abnormal_bone_remodeling0.95260878
117MP0005595_abnormal_vascular_smooth0.93895968
118MP0005275_abnormal_skin_tensile0.93250104
119MP0005310_abnormal_salivary_gland0.92684709
120MP0010234_abnormal_vibrissa_follicle0.92106352
121MP0000537_abnormal_urethra_morphology0.90678012
122MP0003724_increased_susceptibility_to0.89992138
123MP0000955_abnormal_spinal_cord0.89494769
124MP0003935_abnormal_craniofacial_develop0.88592363
125MP0003828_pulmonary_edema0.88174032
126MP0005423_abnormal_somatic_nervous0.87409263
127MP0000432_abnormal_head_morphology0.85757055
128MP0002086_abnormal_extraembryonic_tissu0.84762119
129MP0009384_cardiac_valve_regurgitation0.83587453
130MP0002063_abnormal_learning/memory/cond0.82539843
131MP0008469_abnormal_protein_level0.81546205
132MP0002249_abnormal_larynx_morphology0.81506707
133MP0005174_abnormal_tail_pigmentation0.81258274
134MP0003861_abnormal_nervous_system0.79703926
135MP0002060_abnormal_skin_morphology0.79214650
136MP0003385_abnormal_body_wall0.78951869
137MP0001879_abnormal_lymphatic_vessel0.77953364
138MP0005621_abnormal_cell_physiology0.77370960
139MP0002116_abnormal_craniofacial_bone0.77091622
140MP0002019_abnormal_tumor_incidence0.76771391
141MP0001849_ear_inflammation0.76768816
142MP0004185_abnormal_adipocyte_glucose0.76156960
143MP0002152_abnormal_brain_morphology0.75442483
144MP0003635_abnormal_synaptic_transmissio0.75405509
145MP0006138_congestive_heart_failure0.74685418
146MP0001730_embryonic_growth_arrest0.74548773
147MP0008057_abnormal_DNA_replication0.74306517
148MP0002075_abnormal_coat/hair_pigmentati0.74057186
149MP0002088_abnormal_embryonic_growth/wei0.74016068
150MP0003984_embryonic_growth_retardation0.73285282
151MP0000383_abnormal_hair_follicle0.72348898
152MP0001851_eye_inflammation0.72211398
153MP0003795_abnormal_bone_structure0.71770613
154MP0010678_abnormal_skin_adnexa0.71709719
155MP0005390_skeleton_phenotype0.71261576
156MP0002925_abnormal_cardiovascular_devel0.68975884
157MP0003221_abnormal_cardiomyocyte_apopto0.67560275
158MP0002697_abnormal_eye_size0.67014085
159MP0009703_decreased_birth_body0.66918145
160MP0003631_nervous_system_phenotype0.66264876
161MP0003191_abnormal_cellular_cholesterol0.65850286
162MP0001177_atelectasis0.64718710
163MP0001614_abnormal_blood_vessel0.64299842
164MP0002081_perinatal_lethality0.63893348
165MP0002108_abnormal_muscle_morphology0.63353211

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)3.32191930
2Broad face (HP:0000283)3.28132793
3Hematochezia (HP:0002573)3.27947866
4Eczematoid dermatitis (HP:0000976)3.18106295
5Cerebral aneurysm (HP:0004944)3.17716268
6Recurrent bacterial skin infections (HP:0005406)3.04232457
7Protrusio acetabuli (HP:0003179)2.97962804
8Aortic aneurysm (HP:0004942)2.96194409
9Osteolytic defects of the phalanges of the hand (HP:0009771)2.93254945
10Osteolytic defects of the hand bones (HP:0009699)2.93254945
11Difficulty running (HP:0009046)2.74464353
12Obstructive sleep apnea (HP:0002870)2.70527449
13Disinhibition (HP:0000734)2.70072952
14Recurrent viral infections (HP:0004429)2.69265330
15Increased cerebral lipofuscin (HP:0011813)2.58809177
16Absent frontal sinuses (HP:0002688)2.49975898
17Abnormality of the fingertips (HP:0001211)2.43143126
18Cellulitis (HP:0100658)2.40784236
19Short 4th metacarpal (HP:0010044)2.39625701
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39625701
21Recurrent fungal infections (HP:0002841)2.36044441
22Fragile skin (HP:0001030)2.35099097
23Increased density of long bones (HP:0006392)2.31076749
24Vertebral arch anomaly (HP:0008438)2.29778196
25Overgrowth (HP:0001548)2.29292492
26Periodontitis (HP:0000704)2.26846185
27Subacute progressive viral hepatitis (HP:0006572)2.25161273
28Spinal cord lesions (HP:0100561)2.24715665
29Syringomyelia (HP:0003396)2.24715665
30Shallow orbits (HP:0000586)2.24447808
31Autoimmune thrombocytopenia (HP:0001973)2.22194432
32Mitral regurgitation (HP:0001653)2.22163618
33Neurofibrillary tangles (HP:0002185)2.21871421
34Dilatation of the ascending aorta (HP:0005111)2.21378312
35Interstitial pulmonary disease (HP:0006530)2.19129500
36Ankle contracture (HP:0006466)2.16466149
37Cerebral inclusion bodies (HP:0100314)2.15262538
38Abnormality of macrophages (HP:0004311)2.14412218
39Systemic lupus erythematosus (HP:0002725)2.11190132
40Aortic dissection (HP:0002647)2.10301152
41Osteomyelitis (HP:0002754)2.08087587
42Myocardial infarction (HP:0001658)2.07806253
43Turricephaly (HP:0000262)2.06178381
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.05159095
45Abnormality of the distal phalanx of the thumb (HP:0009617)2.04625614
46Bladder diverticulum (HP:0000015)2.04392975
47Mitral valve prolapse (HP:0001634)2.04266810
48Hyperacusis (HP:0010780)2.03687605
49Broad metatarsal (HP:0001783)1.98401217
50Long toe (HP:0010511)1.98087316
51Atrophic scars (HP:0001075)1.98046355
52Ulnar bowing (HP:0003031)1.97230504
53Thin bony cortex (HP:0002753)1.96940450
54Gingivitis (HP:0000230)1.94774201
55Thick nail (HP:0001805)1.94429761
56Wide anterior fontanel (HP:0000260)1.93752042
57Hyperextensible skin (HP:0000974)1.93509040
58Spinal rigidity (HP:0003306)1.93031164
59Joint laxity (HP:0001388)1.92806525
60Recurrent gram-negative bacterial infections (HP:0005420)1.92609338
61Recurrent skin infections (HP:0001581)1.91723033
62Cervical subluxation (HP:0003308)1.87533809
63Chronic otitis media (HP:0000389)1.86763411
64Colitis (HP:0002583)1.86463284
65Vascular tortuosity (HP:0004948)1.86151286
66Persistence of primary teeth (HP:0006335)1.85947780
67Mitral stenosis (HP:0001718)1.85658344
68Short nail (HP:0001799)1.85534836
69Wormian bones (HP:0002645)1.83400049
70Arnold-Chiari malformation (HP:0002308)1.83071135
71Renovascular hypertension (HP:0100817)1.82566714
72Gastrointestinal carcinoma (HP:0002672)1.81970767
73Malignant gastrointestinal tract tumors (HP:0006749)1.81970767
74Elevated erythrocyte sedimentation rate (HP:0003565)1.81603706
75Myositis (HP:0100614)1.81365373
76Vasculitis (HP:0002633)1.80209161
77Neoplasm of the heart (HP:0100544)1.80145708
78Arterial thrombosis (HP:0004420)1.79954163
79Abnormal platelet volume (HP:0011876)1.79155939
80Dislocated radial head (HP:0003083)1.79065861
81Heterotopia (HP:0002282)1.79035359
82Diastasis recti (HP:0001540)1.78748622
83Arterial tortuosity (HP:0005116)1.78682249
84Spondylolisthesis (HP:0003302)1.78314674
85Biconcave vertebral bodies (HP:0004586)1.78212658
86Emphysema (HP:0002097)1.76867018
87Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76686148
88Abnormality of glycosphingolipid metabolism (HP:0004343)1.76466253
89Abnormality of glycolipid metabolism (HP:0010969)1.76466253
90Abnormality of liposaccharide metabolism (HP:0010968)1.76466253
91Pointed chin (HP:0000307)1.76368331
92Genu recurvatum (HP:0002816)1.76133243
93Inflammation of the large intestine (HP:0002037)1.75557731
94Insomnia (HP:0100785)1.75233972
95Hypoplasia of the iris (HP:0007676)1.74999742
96Rectal prolapse (HP:0002035)1.74142278
97Leukocytosis (HP:0001974)1.74085645
98Cortical dysplasia (HP:0002539)1.74055716
99Spontaneous hematomas (HP:0007420)1.72770346
100Mediastinal lymphadenopathy (HP:0100721)1.72652743
101Increased mean platelet volume (HP:0011877)1.72527456
102Agnosia (HP:0010524)1.72423359
103Neonatal short-limb short stature (HP:0008921)1.71781667
104Eosinophilia (HP:0001880)1.71728102
105Gastrointestinal inflammation (HP:0004386)1.70872019
106Pustule (HP:0200039)1.70809420
107Tibial bowing (HP:0002982)1.70594771
108T lymphocytopenia (HP:0005403)1.69549964
109Chronic obstructive pulmonary disease (HP:0006510)1.69517420
110Obstructive lung disease (HP:0006536)1.69517420
111Spinal muscular atrophy (HP:0007269)1.69125468
112Hammertoe (HP:0001765)1.69029518
113Aneurysm (HP:0002617)1.67605355
114Bicuspid aortic valve (HP:0001647)1.67299904
115Peritonitis (HP:0002586)1.66365478
116Long eyelashes (HP:0000527)1.66271566
117Protruding ear (HP:0000411)1.66229633
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.65715517
119Precocious puberty (HP:0000826)1.64245946
120Bowel diverticulosis (HP:0005222)1.64147642
121Bronchomalacia (HP:0002780)1.64032926
122Nephritis (HP:0000123)1.64006454
123Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63626040
124Narrow palate (HP:0000189)1.63145415
125Macroorchidism (HP:0000053)1.63072765
126Transitional cell carcinoma of the bladder (HP:0006740)1.63003485
127Premature rupture of membranes (HP:0001788)1.62472705
128Blue sclerae (HP:0000592)1.61752980
129Abnormality of T cell number (HP:0011839)1.61510042
130Abnormality of the 4th metacarpal (HP:0010012)1.61467623
131Abnormality of the radial head (HP:0003995)1.61413719
132Recurrent bronchitis (HP:0002837)1.60851388
133Recurrent cutaneous fungal infections (HP:0011370)1.60570923
134Chronic mucocutaneous candidiasis (HP:0002728)1.60570923
135Viral hepatitis (HP:0006562)1.60543000
136Increased variability in muscle fiber diameter (HP:0003557)1.60455823
137Coarse hair (HP:0002208)1.59957412
138Dysostosis multiplex (HP:0000943)1.58875517
139Abnormality of the peritoneum (HP:0002585)1.58786541
140Soft skin (HP:0000977)1.58537193
141Trigonocephaly (HP:0000243)1.58329983
142Thrombocytosis (HP:0001894)1.57873383
143Decreased motor nerve conduction velocity (HP:0003431)1.57822420
144Germ cell neoplasia (HP:0100728)1.57635197
145Deviation of the thumb (HP:0009603)1.56829192
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56724947
147Large earlobe (HP:0009748)1.56347598
148Disproportionate tall stature (HP:0001519)1.56331993
149Lower limb muscle weakness (HP:0007340)1.54643974
150Laryngomalacia (HP:0001601)1.54502163
151Camptodactyly of toe (HP:0001836)1.54308073
152Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.53662863
153Onion bulb formation (HP:0003383)1.53231725
154Increased connective tissue (HP:0009025)1.51636985
155Elfin facies (HP:0004428)1.50648133
156Flat acetabular roof (HP:0003180)1.49517139
157Vertebral compression fractures (HP:0002953)1.49081976
158Cubitus valgus (HP:0002967)1.47365937
159Thin ribs (HP:0000883)1.46949849
160Natal tooth (HP:0000695)1.46245492
161Aplasia involving bones of the extremities (HP:0009825)1.45006902
162Aplasia involving bones of the upper limbs (HP:0009823)1.45006902
163Aplasia of the phalanges of the hand (HP:0009802)1.45006902
164Flat cornea (HP:0007720)1.44923901
165Neuronal loss in central nervous system (HP:0002529)1.44699816
166Relative macrocephaly (HP:0004482)1.43901364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.16099522
2MAP4K12.53598349
3TYK22.40526303
4SCYL22.38386908
5EEF2K2.23680083
6STK102.22049961
7TTN2.21161304
8TRIB32.16040403
9MAP3K102.11813581
10CAMK1D2.08194017
11PKN21.98961021
12TYRO31.98748766
13JAK31.96843266
14JAK11.94697126
15SMG11.92588925
16PTK61.88610750
17PRPF4B1.88247301
18TGFBR21.85214866
19TBK11.80775534
20IRAK41.75107808
21KIT1.73177910
22CSF1R1.67570618
23ERN11.66504712
24NTRK11.57030988
25MARK11.56971812
26MAP3K141.56347236
27FGFR31.55304225
28SGK21.54916581
29EPHB11.53173589
30FGFR41.50034232
31MARK21.49262187
32MAP3K71.47933771
33RIPK11.46403284
34BLK1.42852938
35CAMK1G1.38680753
36LRRK21.35698122
37NTRK21.34237023
38STK41.33592364
39SGK4941.30486946
40SGK2231.30486946
41CDC42BPA1.30241332
42SIK11.29355396
43BRD41.28690453
44IKBKE1.28525950
45CDK61.22937063
46CHUK1.22038419
47IRAK31.21121306
48RPS6KA41.19364394
49KSR21.19266741
50DDR21.17915689
51LATS11.16607600
52PAK41.15967881
53NEK91.15131239
54MAP3K131.11856689
55IKBKB1.11283740
56STK31.11142141
57PRKD21.10992041
58MAP3K61.08815006
59FGFR21.07049418
60TRPM71.06980665
61RPS6KA21.06469140
62LATS21.05153880
63CSK1.04582886
64RET1.04226952
65HCK1.02746905
66CASK1.01562426
67PDGFRA1.01039538
68NEK21.00826622
69CDC71.00169192
70ITK0.99203592
71EPHA30.97795837
72MTOR0.93221343
73BTK0.92092669
74PDGFRB0.91069361
75ZAP700.88860049
76SIK20.86302691
77CLK10.85225444
78MELK0.84639974
79CDK40.84437219
80MAP3K80.83454784
81LCK0.82358460
82KSR10.79628495
83MARK30.79317610
84RPS6KB20.79266908
85PIM10.77359337
86NTRK30.77255316
87WNK10.76962515
88PBK0.75318361
89TXK0.74898488
90STK380.74061051
91ATR0.72105838
92BMX0.71699643
93FRK0.71635453
94CAMKK10.71399158
95ZAK0.70439601
96ALK0.69823332
97MST40.69736213
98EPHA20.68698209
99JAK20.68307988
100MAPK100.67921379
101PAK20.67713038
102RIPK40.66268406
103YES10.66005836
104EGFR0.65669778
105PRKD30.65578185
106AKT30.64413691
107PRKCH0.64161170
108SGK30.63129550
109CDK90.62998927
110SYK0.62445122
111SIK30.61393792
112MET0.60611547
113CAMK40.60101272
114FGR0.59829968
115PDPK10.58868977
116ROCK20.58836635
117TGFBR10.58794602
118LYN0.57673982
119RPS6KC10.57462078
120RPS6KL10.57462078
121ICK0.57446270
122NEK60.56689804
123DYRK1B0.56577602
124MAP3K10.53736117
125RPS6KB10.51875775
126MAP2K30.51189958
127HIPK20.51053564
128TAOK30.50832111
129MAP2K40.50591995
130ABL10.49457763
131FLT30.49051750
132EPHB20.48965193
133MAP3K90.46865174
134MAPK110.44964149
135MAPK70.44844004
136STK110.44052617
137MAPKAPK20.43674253
138RPS6KA60.43279780
139ERBB20.43120743
140PAK60.42681385
141GRK60.42615476
142ATM0.41817293
143PIK3CG0.41535541
144SGK10.41517672
145TLK10.41469563
146TESK20.41225650
147PTK20.40498351
148CDK50.40349802
149PDK10.40003385
150RPS6KA50.39902734
151FGFR10.38526706
152PRKAA10.38393540
153INSR0.38278413
154FES0.37776282
155BRSK20.37635074
156AURKB0.37210468
157DMPK0.37089183
158EIF2AK20.36916865
159CHEK10.36445245

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.33321297
2NF-kappa B signaling pathway_Homo sapiens_hsa040641.98984830
3Osteoclast differentiation_Homo sapiens_hsa043801.95103237
4B cell receptor signaling pathway_Homo sapiens_hsa046621.92890591
5Measles_Homo sapiens_hsa051621.81106081
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80539843
7Antigen processing and presentation_Homo sapiens_hsa046121.77300484
8Chronic myeloid leukemia_Homo sapiens_hsa052201.71320058
9Toxoplasmosis_Homo sapiens_hsa051451.67622321
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67225327
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.60731902
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60277109
13Staphylococcus aureus infection_Homo sapiens_hsa051501.57134221
14Small cell lung cancer_Homo sapiens_hsa052221.51751547
15Influenza A_Homo sapiens_hsa051641.51038178
16Viral myocarditis_Homo sapiens_hsa054161.50632131
17Systemic lupus erythematosus_Homo sapiens_hsa053221.46064787
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.45073854
19Pancreatic cancer_Homo sapiens_hsa052121.44565897
20Herpes simplex infection_Homo sapiens_hsa051681.43083793
21Tuberculosis_Homo sapiens_hsa051521.41478084
22Viral carcinogenesis_Homo sapiens_hsa052031.38341672
23Lysosome_Homo sapiens_hsa041421.37426858
24Malaria_Homo sapiens_hsa051441.36997286
25Apoptosis_Homo sapiens_hsa042101.36135937
26ErbB signaling pathway_Homo sapiens_hsa040121.35235309
27Primary immunodeficiency_Homo sapiens_hsa053401.34781966
28Hepatitis B_Homo sapiens_hsa051611.33530275
29MicroRNAs in cancer_Homo sapiens_hsa052061.33265935
30Pertussis_Homo sapiens_hsa051331.33033200
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29883802
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26718708
33Adherens junction_Homo sapiens_hsa045201.26342496
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25992813
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24094376
36TNF signaling pathway_Homo sapiens_hsa046681.22636997
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21942471
38Legionellosis_Homo sapiens_hsa051341.20791266
39Choline metabolism in cancer_Homo sapiens_hsa052311.20523103
40Shigellosis_Homo sapiens_hsa051311.20144263
41Hematopoietic cell lineage_Homo sapiens_hsa046401.20002991
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19560472
43Prion diseases_Homo sapiens_hsa050201.18426770
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.18289892
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16837715
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16762579
47Proteoglycans in cancer_Homo sapiens_hsa052051.15450665
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11609195
49Focal adhesion_Homo sapiens_hsa045101.11447373
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.11370251
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11364821
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.11112123
53Estrogen signaling pathway_Homo sapiens_hsa049151.11064315
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09989405
55HTLV-I infection_Homo sapiens_hsa051661.08543982
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07602400
57T cell receptor signaling pathway_Homo sapiens_hsa046601.07084440
58Salmonella infection_Homo sapiens_hsa051321.06476194
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.06469829
60GnRH signaling pathway_Homo sapiens_hsa049121.05774554
61Notch signaling pathway_Homo sapiens_hsa043301.05759374
62Axon guidance_Homo sapiens_hsa043601.05577651
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05331283
64Inositol phosphate metabolism_Homo sapiens_hsa005621.05247069
65Chemokine signaling pathway_Homo sapiens_hsa040621.04961319
66Hepatitis C_Homo sapiens_hsa051601.04312602
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04310263
68Amoebiasis_Homo sapiens_hsa051460.98432470
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98149878
70Cell cycle_Homo sapiens_hsa041100.98010364
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97950669
72Allograft rejection_Homo sapiens_hsa053300.97127345
73Colorectal cancer_Homo sapiens_hsa052100.97008459
74Platelet activation_Homo sapiens_hsa046110.96025912
75Acute myeloid leukemia_Homo sapiens_hsa052210.95824892
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95247696
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95182375
78Other glycan degradation_Homo sapiens_hsa005110.94914870
79Gap junction_Homo sapiens_hsa045400.92978814
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.92162636
81Epstein-Barr virus infection_Homo sapiens_hsa051690.91290358
82Long-term potentiation_Homo sapiens_hsa047200.90754913
83Lysine degradation_Homo sapiens_hsa003100.90236316
84Type II diabetes mellitus_Homo sapiens_hsa049300.89453163
85Insulin signaling pathway_Homo sapiens_hsa049100.88990037
86Rap1 signaling pathway_Homo sapiens_hsa040150.88015913
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87210801
88mTOR signaling pathway_Homo sapiens_hsa041500.86086385
89ECM-receptor interaction_Homo sapiens_hsa045120.85893494
90Phagosome_Homo sapiens_hsa041450.85084305
91Graft-versus-host disease_Homo sapiens_hsa053320.85083399
92Thyroid cancer_Homo sapiens_hsa052160.84546019
93Non-small cell lung cancer_Homo sapiens_hsa052230.82919324
94Prostate cancer_Homo sapiens_hsa052150.82477072
95One carbon pool by folate_Homo sapiens_hsa006700.82002272
96p53 signaling pathway_Homo sapiens_hsa041150.80855657
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80831845
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80268016
99AMPK signaling pathway_Homo sapiens_hsa041520.79074046
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77686722
101Melanogenesis_Homo sapiens_hsa049160.75399405
102Renin-angiotensin system_Homo sapiens_hsa046140.74622092
103Endometrial cancer_Homo sapiens_hsa052130.73833207
104Gastric acid secretion_Homo sapiens_hsa049710.72473746
105Renal cell carcinoma_Homo sapiens_hsa052110.72053042
106TGF-beta signaling pathway_Homo sapiens_hsa043500.71416746
107Prolactin signaling pathway_Homo sapiens_hsa049170.71018183
108Long-term depression_Homo sapiens_hsa047300.70864799
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70340483
110Hippo signaling pathway_Homo sapiens_hsa043900.69850944
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69330775
112Cholinergic synapse_Homo sapiens_hsa047250.68922032
113FoxO signaling pathway_Homo sapiens_hsa040680.67524553
114Bile secretion_Homo sapiens_hsa049760.66691990
115Cocaine addiction_Homo sapiens_hsa050300.66483185
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66157289
117HIF-1 signaling pathway_Homo sapiens_hsa040660.66115556
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65838841
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65495256
120Insulin resistance_Homo sapiens_hsa049310.65214175
121Melanoma_Homo sapiens_hsa052180.64371428
122Endocytosis_Homo sapiens_hsa041440.64239550
123Dilated cardiomyopathy_Homo sapiens_hsa054140.64168916
124Ras signaling pathway_Homo sapiens_hsa040140.63724394
125Tight junction_Homo sapiens_hsa045300.62869900
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62321105
127MAPK signaling pathway_Homo sapiens_hsa040100.62129725
128Pathways in cancer_Homo sapiens_hsa052000.61855505
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60396802
130Caffeine metabolism_Homo sapiens_hsa002320.59607204
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59193139
132Fatty acid biosynthesis_Homo sapiens_hsa000610.59000617
133Glioma_Homo sapiens_hsa052140.58436704
134Dorso-ventral axis formation_Homo sapiens_hsa043200.57575156
135DNA replication_Homo sapiens_hsa030300.54318333
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49999955
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49960518
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49758509
139Non-homologous end-joining_Homo sapiens_hsa034500.49724149
140VEGF signaling pathway_Homo sapiens_hsa043700.48723324
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47503336
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.46457546
143Bladder cancer_Homo sapiens_hsa052190.46057084
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.45583189

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