ANKHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.25607783
2nuclear pore complex assembly (GO:0051292)5.01926391
3cytoplasmic mRNA processing body assembly (GO:0033962)4.64422679
4nuclear pore organization (GO:0006999)4.61594256
5regulation of histone H3-K27 methylation (GO:0061085)4.51907471
6histone H3-K4 trimethylation (GO:0080182)4.51465207
7interkinetic nuclear migration (GO:0022027)4.36944172
8pre-miRNA processing (GO:0031054)3.99723715
9histone H3-K4 methylation (GO:0051568)3.94980323
10positive regulation of granulocyte differentiation (GO:0030854)3.92903123
11regulation of DNA endoreduplication (GO:0032875)3.89897162
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.89790619
13pore complex assembly (GO:0046931)3.75572904
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.68117257
15regulation of translation, ncRNA-mediated (GO:0045974)3.68117257
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.68117257
17protein K11-linked deubiquitination (GO:0035871)3.67926333
18regulation of RNA export from nucleus (GO:0046831)3.67316565
19positive regulation of gamma-delta T cell activation (GO:0046645)3.61742603
20negative regulation of histone methylation (GO:0031061)3.56659819
21N-terminal protein amino acid acetylation (GO:0006474)3.54843177
22histone H3-K36 demethylation (GO:0070544)3.52328269
23hepatocyte apoptotic process (GO:0097284)3.51748697
24positive regulation of histone H3-K4 methylation (GO:0051571)3.50212569
25peptidyl-lysine trimethylation (GO:0018023)3.49238296
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48480637
27snRNA transcription (GO:0009301)3.47729598
28positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.34767397
29positive regulation by host of viral transcription (GO:0043923)3.34295050
30positive regulation of histone deacetylation (GO:0031065)3.34013909
31NLS-bearing protein import into nucleus (GO:0006607)3.33646050
32regulation of histone H3-K9 methylation (GO:0051570)3.31538896
33glucocorticoid receptor signaling pathway (GO:0042921)3.29912059
34cellular response to ethanol (GO:0071361)3.29083537
35histone H3-K9 demethylation (GO:0033169)3.21083052
36histone lysine methylation (GO:0034968)3.20758887
37histone H3-K9 methylation (GO:0051567)3.09932756
38histone lysine demethylation (GO:0070076)3.06480334
39regulation of granulocyte differentiation (GO:0030852)3.05894160
40regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.05474590
41positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.05474590
42positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.04212622
43regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.04212622
44establishment of protein localization to Golgi (GO:0072600)3.04169674
45protein K48-linked deubiquitination (GO:0071108)3.03912193
46regulation of nucleobase-containing compound transport (GO:0032239)3.02336927
47histone deubiquitination (GO:0016578)3.00581139
48histone H3-K9 modification (GO:0061647)2.98954712
49sister chromatid cohesion (GO:0007062)2.98942327
50regulation of gamma-delta T cell differentiation (GO:0045586)2.98296779
51regulation of B cell receptor signaling pathway (GO:0050855)2.96378850
52meiotic chromosome segregation (GO:0045132)2.93612282
53corticosteroid receptor signaling pathway (GO:0031958)2.93020836
54peptidyl-lysine methylation (GO:0018022)2.92960525
55positive regulation of mRNA catabolic process (GO:0061014)2.91157757
56regulation of gamma-delta T cell activation (GO:0046643)2.89345763
57positive regulation of histone methylation (GO:0031062)2.87927565
58regulation of mRNA catabolic process (GO:0061013)2.87228419
59histone demethylation (GO:0016577)2.85923237
60positive regulation of DNA-templated transcription, initiation (GO:2000144)2.84732968
61DNA topological change (GO:0006265)2.81044934
62regulation of interleukin-12 biosynthetic process (GO:0045075)2.73582244
63regulation of histone methylation (GO:0031060)2.71382042
64histone H4-K16 acetylation (GO:0043984)2.70706127
65protein targeting to Golgi (GO:0000042)2.69437570
66RNA stabilization (GO:0043489)2.69010359
67mRNA stabilization (GO:0048255)2.69010359
68histone H4-K5 acetylation (GO:0043981)2.69003680
69histone H4-K8 acetylation (GO:0043982)2.69003680
70T cell selection (GO:0045058)2.68059100
71poly(A)+ mRNA export from nucleus (GO:0016973)2.67834292
72DNA geometric change (GO:0032392)2.65356845
73regulation of protein polyubiquitination (GO:1902914)2.64885269
74histone mRNA catabolic process (GO:0071044)2.64333633
75DNA duplex unwinding (GO:0032508)2.63562336
76B cell receptor signaling pathway (GO:0050853)2.63429130
77mitotic chromosome condensation (GO:0007076)2.62353179
78heterochromatin organization (GO:0070828)2.62259291
79radial glial cell differentiation (GO:0060019)2.61599246
80peptidyl-lysine dimethylation (GO:0018027)2.60967595
81negative regulation of granulocyte differentiation (GO:0030853)2.58650605
82nucleus localization (GO:0051647)2.58132959
83regulation of histone H3-K4 methylation (GO:0051569)2.57831140
84positive thymic T cell selection (GO:0045059)2.57295728
85retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56984595
86negative regulation of cell killing (GO:0031342)2.56704181
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56704181
88regulation of interferon-beta biosynthetic process (GO:0045357)2.56330054
89positive regulation of protein deacetylation (GO:0090312)2.56191518
90histone H4 acetylation (GO:0043967)2.55039133
91negative regulation of DNA repair (GO:0045738)2.54864201
92mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.54522389
93positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.54522389
94Golgi to endosome transport (GO:0006895)2.54270465
95embryonic camera-type eye morphogenesis (GO:0048596)2.53665881
96I-kappaB phosphorylation (GO:0007252)2.52916717
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52894202
98monoubiquitinated protein deubiquitination (GO:0035520)2.52865819
99gene silencing by RNA (GO:0031047)2.52477618
100auditory receptor cell differentiation (GO:0042491)2.52392499
101protein dealkylation (GO:0008214)2.51826974
102protein demethylation (GO:0006482)2.51826974
103thymic T cell selection (GO:0045061)2.51668755
104insulin-like growth factor receptor signaling pathway (GO:0048009)2.51360519
105nucleus organization (GO:0006997)2.51341222
106histone methylation (GO:0016571)2.51035299
107regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.49491052
108embryonic hemopoiesis (GO:0035162)2.48596819
109definitive hemopoiesis (GO:0060216)2.47652881
110chromatin assembly (GO:0031497)2.47239233
111regulation of mRNA 3-end processing (GO:0031440)2.46328734
112response to UV-C (GO:0010225)2.45602754
113positive regulation of mRNA 3-end processing (GO:0031442)2.43955628
114positive T cell selection (GO:0043368)2.43905172
115protein localization to microtubule cytoskeleton (GO:0072698)2.43544769
116histone acetylation (GO:0016573)2.42856481
117alternative mRNA splicing, via spliceosome (GO:0000380)2.42427862
118regulation of establishment of cell polarity (GO:2000114)2.42355093
119mitotic nuclear envelope disassembly (GO:0007077)2.41808691
120gene silencing (GO:0016458)2.41804382
121negative regulation of DNA-dependent DNA replication (GO:2000104)2.40741735
122phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.40490081
123negative T cell selection (GO:0043383)2.35749573
124positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.35185804
125embryonic retina morphogenesis in camera-type eye (GO:0060059)2.32577289
126negative thymic T cell selection (GO:0045060)2.31024924
127regulation of sister chromatid cohesion (GO:0007063)2.30563496
128negative regulation of histone modification (GO:0031057)2.30317479
129stress granule assembly (GO:0034063)2.28464474
130nuclear envelope disassembly (GO:0051081)2.28063572
131membrane disassembly (GO:0030397)2.28063572
132regulation of centriole replication (GO:0046599)2.27162780
133negative regulation of chromatin modification (GO:1903309)2.26397161
134regulation of mitotic spindle organization (GO:0060236)2.25346080
135positive regulation of mitotic sister chromatid separation (GO:1901970)2.24786225
136positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.24786225
137positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.24786225
138growth hormone receptor signaling pathway (GO:0060396)2.22752299
139dosage compensation (GO:0007549)2.22644097
140positive regulation of gene expression, epigenetic (GO:0045815)2.22489639
141positive regulation of B cell differentiation (GO:0045579)2.21790572
142negative regulation of B cell proliferation (GO:0030889)2.21622587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51858334
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.91446030
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88076677
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.66605091
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.62180867
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58272068
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.95450107
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90809206
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.77664780
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65786497
11MYC_22102868_ChIP-Seq_BL_Human2.58348149
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42684995
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42312026
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36145539
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34217023
16GATA1_22025678_ChIP-Seq_K562_Human2.27953849
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15387435
18SCL_19346495_ChIP-Seq_HPC-7_Human2.08977236
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04051410
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.02777781
21RUNX_20019798_ChIP-Seq_JUKART_Human2.00418281
22* TCF7_22412390_ChIP-Seq_EML_Mouse1.99645812
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85565219
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79355408
25AR_21572438_ChIP-Seq_LNCaP_Human1.75035501
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71868308
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70861265
28MYB_26560356_Chip-Seq_TH2_Human1.70209806
29MYB_26560356_Chip-Seq_TH1_Human1.69319427
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67985359
31* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67823782
32* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67660854
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.66970419
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66271106
35PKCTHETA_26484144_Chip-Seq_BREAST_Human1.60422814
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60249417
37FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59033864
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.56393125
39ER_23166858_ChIP-Seq_MCF-7_Human1.54583342
40CIITA_25753668_ChIP-Seq_RAJI_Human1.52508114
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.46793587
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42299914
43MAF_26560356_Chip-Seq_TH1_Human1.41879241
44TP53_16413492_ChIP-PET_HCT116_Human1.41094262
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38642847
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37905742
47* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37440713
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37343001
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37220165
50TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36747525
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36194868
52UTX_26944678_Chip-Seq_JUKART_Human1.36090876
53VDR_21846776_ChIP-Seq_THP-1_Human1.33454152
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.32980091
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29786753
56STAT3_23295773_ChIP-Seq_U87_Human1.29737858
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28481678
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28135963
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.25843045
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.25501482
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24053476
62CHD1_26751641_Chip-Seq_LNCaP_Human1.24042587
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23552688
64KDM2B_26808549_Chip-Seq_DND41_Human1.22900561
65SPI1_23127762_ChIP-Seq_K562_Human1.22672760
66GATA3_26560356_Chip-Seq_TH2_Human1.21811511
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21700779
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19974969
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18888527
70FUS_26573619_Chip-Seq_HEK293_Human1.18857234
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18767606
72BRD4_25478319_ChIP-Seq_HGPS_Human1.18353301
73AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16658947
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15850925
75* TCF4_23295773_ChIP-Seq_U87_Human1.15496690
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15496259
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15496259
78PU_27001747_Chip-Seq_BMDM_Mouse1.15342471
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.14699021
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13509923
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12828850
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12219789
83* KDM5A_27292631_Chip-Seq_BREAST_Human1.11895341
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11690131
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.11269076
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.10598986
87GATA3_27048872_Chip-Seq_THYMUS_Human1.10597600
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09560595
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.09517392
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.09032637
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06604186
92GATA6_25053715_ChIP-Seq_YYC3_Human1.06535932
93* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06447266
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05888812
95* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05357757
96AR_21909140_ChIP-Seq_LNCAP_Human1.04980566
97VDR_24763502_ChIP-Seq_THP-1_Human1.04316251
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03730899
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02041866
100FOXA2_19822575_ChIP-Seq_HepG2_Human1.01992906
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01685681
102VDR_24787735_ChIP-Seq_THP-1_Human1.01130702
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00902072
104* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99873520
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99737281
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99210720
107* RUNX1_22412390_ChIP-Seq_EML_Mouse0.97297399
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95727396
109* NCOR1_26117541_ChIP-Seq_K562_Human0.95684745
110FLI1_27457419_Chip-Seq_LIVER_Mouse0.95091939
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.95039415
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94980917
113* EWS_26573619_Chip-Seq_HEK293_Human0.94785202
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94626515
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.94503535
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94494597
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94494597
118* SPI1_23547873_ChIP-Seq_NB4_Human0.94106856
119RXR_22108803_ChIP-Seq_LS180_Human0.92837306
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92307851
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91990368
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91917917
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91601485
124GATA2_19941826_ChIP-Seq_K562_Human0.90079960
125AHR_22903824_ChIP-Seq_MCF-7_Human0.88165006
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87548711
127TP63_17297297_ChIP-ChIP_HaCaT_Human0.87398643
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87293545
129SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87222389
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.84966199
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84900525
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83801465
133KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81997008
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81788452
135PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81522152
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80674104
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80531659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.09620225
2MP0010352_gastrointestinal_tract_polyps2.76527586
3MP0005076_abnormal_cell_differentiation2.64623626
4MP0008057_abnormal_DNA_replication2.60194426
5MP0003300_gastrointestinal_ulcer2.60063944
6MP0002166_altered_tumor_susceptibility2.51128072
7MP0003656_abnormal_erythrocyte_physiolo2.38381063
8MP0002396_abnormal_hematopoietic_system2.29273493
9MP0004381_abnormal_hair_follicle2.21186956
10MP0004808_abnormal_hematopoietic_stem2.09112791
11MP0002009_preneoplasia2.03929043
12MP0010307_abnormal_tumor_latency2.03225054
13MP0008877_abnormal_DNA_methylation1.94539035
14MP0005075_abnormal_melanosome_morpholog1.90607948
15MP0002006_tumorigenesis1.90372447
16MP0003705_abnormal_hypodermis_morpholog1.84405769
17MP0009278_abnormal_bone_marrow1.83725471
18MP0003787_abnormal_imprinting1.83070230
19MP0001835_abnormal_antigen_presentation1.81940990
20MP0010094_abnormal_chromosome_stability1.81937991
21MP0008995_early_reproductive_senescence1.79664166
22MP0010234_abnormal_vibrissa_follicle1.76864356
23MP0002138_abnormal_hepatobiliary_system1.69154905
24MP0004264_abnormal_extraembryonic_tissu1.66209262
25MP0003111_abnormal_nucleus_morphology1.64649040
26MP0000383_abnormal_hair_follicle1.64206505
27MP0001800_abnormal_humoral_immune1.61209021
28MP0003763_abnormal_thymus_physiology1.60773937
29MP0003890_abnormal_embryonic-extraembry1.58137400
30MP0002877_abnormal_melanocyte_morpholog1.53682536
31MP0010678_abnormal_skin_adnexa1.52441220
32MP0005174_abnormal_tail_pigmentation1.51623118
33MP0003077_abnormal_cell_cycle1.50806553
34MP0003566_abnormal_cell_adhesion1.47481545
35MP0003183_abnormal_peptide_metabolism1.46432115
36MP0003045_fibrosis1.44905507
37MP0005387_immune_system_phenotype1.40859637
38MP0001790_abnormal_immune_system1.40859637
39MP0001873_stomach_inflammation1.38269901
40MP0002398_abnormal_bone_marrow1.37908497
41MP0000703_abnormal_thymus_morphology1.37406001
42MP0006054_spinal_hemorrhage1.33218994
43MP0008961_abnormal_basal_metabolism1.32017821
44MP0004947_skin_inflammation1.30237263
45MP0003121_genomic_imprinting1.29764813
46MP0004197_abnormal_fetal_growth/weight/1.29409489
47MP0002254_reproductive_system_inflammat1.27364568
48MP0002452_abnormal_antigen_presenting1.26955469
49MP0008007_abnormal_cellular_replicative1.26599816
50MP0004185_abnormal_adipocyte_glucose1.24983571
51MP0000371_diluted_coat_color1.24218328
52MP0009115_abnormal_fat_cell1.21705046
53MP0005451_abnormal_body_composition1.21281367
54MP0002095_abnormal_skin_pigmentation1.20397234
55MP0002086_abnormal_extraembryonic_tissu1.19963455
56MP0001545_abnormal_hematopoietic_system1.19850774
57MP0005397_hematopoietic_system_phenotyp1.19850774
58MP0009703_decreased_birth_body1.15509154
59MP0001915_intracranial_hemorrhage1.13803463
60MP0000350_abnormal_cell_proliferation1.13130991
61MP0002088_abnormal_embryonic_growth/wei1.13079383
62MP0003984_embryonic_growth_retardation1.12176512
63MP0000685_abnormal_immune_system1.11836738
64MP0002420_abnormal_adaptive_immunity1.10853700
65MP0005380_embryogenesis_phenotype1.08946388
66MP0001672_abnormal_embryogenesis/_devel1.08946388
67MP0001819_abnormal_immune_cell1.08672000
68MP0004883_abnormal_blood_vessel1.06902749
69MP0002722_abnormal_immune_system1.06286542
70MP0006292_abnormal_olfactory_placode1.05056724
71MP0000716_abnormal_immune_system1.04163834
72MP0003303_peritoneal_inflammation1.03860628
73MP0002723_abnormal_immune_serum1.03805029
74MP0008058_abnormal_DNA_repair1.03798445
75MP0005671_abnormal_response_to1.02033482
76MP0002928_abnormal_bile_duct1.01210119
77MP0003252_abnormal_bile_duct1.01187327
78MP0000427_abnormal_hair_cycle1.00064858
79MP0000689_abnormal_spleen_morphology0.99747608
80MP0002084_abnormal_developmental_patter0.99544345
81MP0002925_abnormal_cardiovascular_devel0.99008590
82MP0001879_abnormal_lymphatic_vessel0.98659503
83MP0010155_abnormal_intestine_physiology0.97814236
84MP0005408_hypopigmentation0.94257778
85MP0003567_abnormal_fetal_cardiomyocyte0.94091378
86MP0002098_abnormal_vibrissa_morphology0.93949993
87MP0002876_abnormal_thyroid_physiology0.92760884
88MP0003693_abnormal_embryo_hatching0.91992689
89MP0003091_abnormal_cell_migration0.91359824
90MP0000733_abnormal_muscle_development0.90979323
91MP0001730_embryonic_growth_arrest0.90480525
92MP0002405_respiratory_system_inflammati0.88801993
93MP0005666_abnormal_adipose_tissue0.87474920
94MP0003436_decreased_susceptibility_to0.87081020
95MP0003935_abnormal_craniofacial_develop0.86870426
96MP0003172_abnormal_lysosome_physiology0.86668453
97MP0005220_abnormal_exocrine_pancreas0.86518214
98MP0000428_abnormal_craniofacial_morphol0.86496079
99MP0002429_abnormal_blood_cell0.86418681
100MP0009672_abnormal_birth_weight0.86046657
101MP0000613_abnormal_salivary_gland0.85799425
102MP0002060_abnormal_skin_morphology0.84980038
103MP0005248_abnormal_Harderian_gland0.84697938
104MP0005000_abnormal_immune_tolerance0.84248610
105MP0002168_other_aberrant_phenotype0.83294055
106MP0005310_abnormal_salivary_gland0.83005830
107MP0000490_abnormal_crypts_of0.82597583
108MP0002075_abnormal_coat/hair_pigmentati0.81381960
109MP0001849_ear_inflammation0.80888885
110MP0000015_abnormal_ear_pigmentation0.80711675
111MP0003943_abnormal_hepatobiliary_system0.80710079
112MP0000432_abnormal_head_morphology0.79984890
113MP0005023_abnormal_wound_healing0.79386748
114MP0005409_darkened_coat_color0.78881511
115MP0002419_abnormal_innate_immunity0.78578134
116MP0001293_anophthalmia0.78288035
117MP0000377_abnormal_hair_follicle0.78088004
118MP0009780_abnormal_chondrocyte_physiolo0.77894290
119MP0002085_abnormal_embryonic_tissue0.77487765
120MP0001697_abnormal_embryo_size0.75928247
121MP0001324_abnormal_eye_pigmentation0.73476651
122MP0001186_pigmentation_phenotype0.71856278
123MP0003646_muscle_fatigue0.71450436
124MP0002163_abnormal_gland_morphology0.70934735
125MP0000566_synostosis0.68298838
126MP0004043_abnormal_pH_regulation0.67021099
127MP0003868_abnormal_feces_composition0.66678588
128MP0005647_abnormal_sex_gland0.66643095
129MP0000631_abnormal_neuroendocrine_gland0.66291094
130MP0003866_abnormal_defecation0.66124063
131MP0002019_abnormal_tumor_incidence0.64768476
132MP0002970_abnormal_white_adipose0.64541297
133MP0001929_abnormal_gametogenesis0.63706971
134MP0003724_increased_susceptibility_to0.63131811
135MP0000609_abnormal_liver_physiology0.63031196

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.91204904
2Volvulus (HP:0002580)3.92525721
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07632254
4Lip pit (HP:0100267)3.02731034
5Urethral obstruction (HP:0000796)3.00591805
6Long eyelashes (HP:0000527)2.99452009
7Abnormality of incisor morphology (HP:0011063)2.90959011
8Macroorchidism (HP:0000053)2.87422514
9Hyperkalemia (HP:0002153)2.84661446
10Recurrent viral infections (HP:0004429)2.73343435
11Short 4th metacarpal (HP:0010044)2.72142705
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.72142705
13Deep philtrum (HP:0002002)2.66684143
14Absent frontal sinuses (HP:0002688)2.66451050
15Colitis (HP:0002583)2.57221411
16Narrow palate (HP:0000189)2.54147009
17Abnormality of the nasal septum (HP:0000419)2.52191815
18Tubulointerstitial nephritis (HP:0001970)2.51591436
19Submucous cleft hard palate (HP:0000176)2.50302554
20Fair hair (HP:0002286)2.47020204
21Abnormal delayed hypersensitivity skin test (HP:0002963)2.46262916
22Hematochezia (HP:0002573)2.39486910
23Abnormality of chromosome segregation (HP:0002916)2.36803770
2411 pairs of ribs (HP:0000878)2.34688964
25Truncal obesity (HP:0001956)2.31362165
26Anal stenosis (HP:0002025)2.30193930
27Deep palmar crease (HP:0006191)2.29692693
28Hypoplastic labia majora (HP:0000059)2.29651955
29Obsessive-compulsive behavior (HP:0000722)2.28101868
30T lymphocytopenia (HP:0005403)2.24258629
31Heterotopia (HP:0002282)2.22483855
32Acute myeloid leukemia (HP:0004808)2.20729289
33Increased nuchal translucency (HP:0010880)2.20282323
34Prominent nose (HP:0000448)2.20092428
35Periodontitis (HP:0000704)2.18276910
36Hypoplastic iliac wings (HP:0002866)2.17739409
37Ectopic kidney (HP:0000086)2.16902549
38Genetic anticipation (HP:0003743)2.15624259
39Trigonocephaly (HP:0000243)2.15569567
40Acute lymphatic leukemia (HP:0006721)2.14219722
41Generalized hypopigmentation of hair (HP:0011358)2.13681153
42Inflammation of the large intestine (HP:0002037)2.12725810
43Abnormality of chromosome stability (HP:0003220)2.12193463
44Panhypogammaglobulinemia (HP:0003139)2.12170065
45Syringomyelia (HP:0003396)2.12140661
46Spinal cord lesions (HP:0100561)2.12140661
47Abnormality of chloride homeostasis (HP:0011422)2.10956598
48Hypoplasia of the thymus (HP:0000778)2.10265196
49Agammaglobulinemia (HP:0004432)2.09801486
50Low anterior hairline (HP:0000294)2.05929761
51Abnormality of T cell number (HP:0011839)2.05784680
52Recurrent fungal infections (HP:0002841)2.05400595
53Gastrointestinal inflammation (HP:0004386)2.03563523
54Neoplasm of the oral cavity (HP:0100649)2.03472600
55Chronic hepatic failure (HP:0100626)1.99630995
56Hypoplastic ischia (HP:0003175)1.98171100
57Abnormality of the labia majora (HP:0012881)1.98155858
58Chromsome breakage (HP:0040012)1.98076155
59Impulsivity (HP:0100710)1.96621072
60Viral hepatitis (HP:0006562)1.95836518
61Neoplasm of striated muscle (HP:0009728)1.94465976
62Deviation of the thumb (HP:0009603)1.94254047
63Widely spaced teeth (HP:0000687)1.93955131
64Overlapping toe (HP:0001845)1.92673427
65Proximal placement of thumb (HP:0009623)1.91879765
66Limb hypertonia (HP:0002509)1.91825890
67Abnormality of the renal cortex (HP:0011035)1.91175861
68Basal cell carcinoma (HP:0002671)1.90723996
69Recurrent cutaneous fungal infections (HP:0011370)1.90341737
70Chronic mucocutaneous candidiasis (HP:0002728)1.90341737
71Cutis marmorata (HP:0000965)1.89700952
72Malignant gastrointestinal tract tumors (HP:0006749)1.87857949
73Gastrointestinal carcinoma (HP:0002672)1.87857949
74Limited elbow extension (HP:0001377)1.87625079
75Thick eyebrow (HP:0000574)1.87546370
76Subacute progressive viral hepatitis (HP:0006572)1.87526807
77Albinism (HP:0001022)1.87249111
78Smooth philtrum (HP:0000319)1.86461134
79Abnormality of the incisor (HP:0000676)1.86330845
80Tented upper lip vermilion (HP:0010804)1.86186764
81Cerebral aneurysm (HP:0004944)1.85771996
82Thickened helices (HP:0000391)1.85757948
83Biliary tract neoplasm (HP:0100574)1.85049572
84Neonatal hypoglycemia (HP:0001998)1.84890103
85Abnormality of the 4th metacarpal (HP:0010012)1.82551006
86Supernumerary ribs (HP:0005815)1.82231313
87Abnormality of the renal medulla (HP:0100957)1.81679427
88Poikilocytosis (HP:0004447)1.81292874
89Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80484517
90Capillary hemangiomas (HP:0005306)1.80040491
91Ependymoma (HP:0002888)1.79779811
92IgM deficiency (HP:0002850)1.78761424
93Rhabdomyosarcoma (HP:0002859)1.78505617
94Aplasia/Hypoplasia of the thymus (HP:0010515)1.78413022
95Hyperacusis (HP:0010780)1.77562465
96Cafe-au-lait spot (HP:0000957)1.76758479
97Menstrual irregularities (HP:0000858)1.76532205
98Rectal prolapse (HP:0002035)1.76385149
99Thyroiditis (HP:0100646)1.75884448
100Skull defect (HP:0001362)1.73863238
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73326970
102Synophrys (HP:0000664)1.73234950
103Abnormality of the aortic arch (HP:0012303)1.73018366
104Curly hair (HP:0002212)1.72654526
105Oligodactyly (hands) (HP:0001180)1.72286107
106Abnormality of T cell physiology (HP:0011840)1.72129702
107Long clavicles (HP:0000890)1.69895252
108Sandal gap (HP:0001852)1.69704793
109Papillary thyroid carcinoma (HP:0002895)1.69546955
110Abnormal hair whorl (HP:0010721)1.69487989
111Cystic hygroma (HP:0000476)1.69238531
112Abnormality of the astrocytes (HP:0100707)1.67808622
113Astrocytoma (HP:0009592)1.67808622
114Severe combined immunodeficiency (HP:0004430)1.67743707
115Dysmetric saccades (HP:0000641)1.66759386
116Aortic aneurysm (HP:0004942)1.66177856
117Highly arched eyebrow (HP:0002553)1.66176209
118Abnormality of the ischium (HP:0003174)1.66163080
119Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66077391
120IgA deficiency (HP:0002720)1.65787233
121Transitional cell carcinoma of the bladder (HP:0006740)1.65287450
122Neoplasm of the tracheobronchial system (HP:0100552)1.65282238
123Broad thumb (HP:0011304)1.64896488
124Rib fusion (HP:0000902)1.63285842
125Hypoplasia of the maxilla (HP:0000327)1.63124961
126Spondylolisthesis (HP:0003302)1.62410393
127Milia (HP:0001056)1.62357154
128Broad palm (HP:0001169)1.62120912
129Sloping forehead (HP:0000340)1.61759748
130Myelodysplasia (HP:0002863)1.61342170
131Acanthocytosis (HP:0001927)1.60020172
132Glioma (HP:0009733)1.59931150
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59869350
134Tubular atrophy (HP:0000092)1.59442061
135Clubbing of toes (HP:0100760)1.59337816
136Chronic diarrhea (HP:0002028)1.58891582
137Abnormality of DNA repair (HP:0003254)1.58746543
138Elfin facies (HP:0004428)1.58721850
139Abnormality of the radial head (HP:0003995)1.58713501
140Medulloblastoma (HP:0002885)1.58188687
141Gaze-evoked nystagmus (HP:0000640)1.57342802
142Protruding tongue (HP:0010808)1.57159609
143Chromosomal breakage induced by crosslinking agents (HP:0003221)1.57008667
144Recurrent skin infections (HP:0001581)1.56612168
145Nephronophthisis (HP:0000090)1.56485031
146Progressive cerebellar ataxia (HP:0002073)1.56283010
147Ureteral obstruction (HP:0006000)1.56099585
148Renovascular hypertension (HP:0100817)1.56082819
149Vertebral arch anomaly (HP:0008438)1.54507659
150Abnormality of T cells (HP:0002843)1.52921786
151Skin tags (HP:0010609)1.52885574
152Dislocated radial head (HP:0003083)1.52369997
153Tapered finger (HP:0001182)1.51768906
154Supernumerary bones of the axial skeleton (HP:0009144)1.51482251
155Spinal muscular atrophy (HP:0007269)1.51205756
156Abnormality of the frontal sinuses (HP:0002687)1.51038663
157Large earlobe (HP:0009748)1.50042484
158Cellulitis (HP:0100658)1.48273987
159Leiomyosarcoma (HP:0100243)1.48057624
160Uterine leiomyosarcoma (HP:0002891)1.48057624
161High pitched voice (HP:0001620)1.46187886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.01063105
2BRD43.04757695
3CAMK1D2.79260180
4CAMK1G2.53926863
5FRK2.31040810
6AKT32.24348687
7LATS12.23472357
8TAOK32.15206951
9MAP3K102.07784452
10CDC71.96434394
11EEF2K1.93341358
12MAP4K11.93014601
13BLK1.79713595
14RIPK41.69183615
15BRSK21.65489922
16FGFR31.65006521
17BMPR1B1.53513499
18STK101.53106731
19CDK61.52627870
20IRAK41.51162797
21NUAK11.50334587
22PTK61.44647294
23MAP3K141.43663347
24SIK11.43514015
25TYK21.39775054
26TNK21.39640530
27MTOR1.37228404
28MARK21.37119481
29JAK31.36969301
30CHUK1.36582219
31RIPK11.36125526
32JAK11.33117372
33ATR1.31619124
34KSR11.31083431
35SCYL21.29419114
36STK31.25312869
37SIK21.24042486
38SGK31.23107656
39CDK91.22617215
40NEK21.19605649
41CDK81.17395847
42CDK31.15941602
43IRAK11.13095136
44TAOK11.12696842
45FGFR41.09854378
46SGK21.09174171
47STK41.07261037
48FGFR21.05605459
49TTN1.05586785
50INSRR1.02638881
51PDGFRB1.02366180
52ATM1.02024310
53CDK41.00445381
54NEK90.98973902
55CSF1R0.97460204
56SGK2230.97313407
57SGK4940.97313407
58WNK10.97121678
59TXK0.96796826
60PRKD30.96700325
61ITK0.96016346
62DMPK0.95734545
63CDC42BPA0.95395917
64TGFBR20.94541074
65MAP3K70.93393721
66RAF10.88354570
67CHEK10.87898118
68PKN20.86901445
69TGFBR10.85477338
70PIK3CA0.83424033
71MKNK20.83045440
72KSR20.82556426
73HIPK20.82149304
74ALK0.82070475
75PNCK0.81363519
76RPS6KB20.79983120
77TYRO30.79039778
78PASK0.78632993
79RPS6KA40.77504658
80TTK0.77366430
81MKNK10.76811171
82ERN10.74855800
83NTRK30.73515303
84MELK0.73326584
85STK110.73274689
86MARK30.73006043
87KIT0.71396182
88PDGFRA0.71179089
89ZAK0.70208199
90PRKCH0.68742287
91YES10.67883533
92FLT30.66958408
93TRPM70.66301362
94HCK0.66269825
95PIM10.66240163
96GRK60.65818027
97NLK0.63261193
98PRKDC0.62854945
99PRKAA20.62664698
100PLK40.61332715
101MAP3K130.61105771
102PRKD20.61066095
103CDK20.60887139
104ZAP700.60838400
105PDK10.60254480
106MAP3K30.60139995
107IKBKB0.60116706
108IKBKE0.58841878
109MAPK140.58632796
110TEC0.58428995
111LCK0.57474995
112SYK0.56584134
113AURKB0.56325442
114SGK10.56309567
115EPHA30.54865690
116PIK3CG0.54361408
117CSK0.53985989
118RET0.53619624
119PLK20.53160540
120BTK0.52528598
121JAK20.51262531
122MAPK10.50581553
123CLK10.50454949
124ERBB20.49834970
125STK38L0.49650998
126ACVR1B0.49136363
127MAP3K20.48912737
128CDK10.47892214
129CDK70.47537147
130TAF10.47048299
131BMPR20.47010808
132CSNK1D0.46679253
133CAMK40.46642088
134FGFR10.46140394
135EGFR0.45088281
136AKT10.44734399
137MAP2K30.43367372

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.38124506
2Primary immunodeficiency_Homo sapiens_hsa053401.88862707
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.80712610
4Non-homologous end-joining_Homo sapiens_hsa034501.78147497
5B cell receptor signaling pathway_Homo sapiens_hsa046621.77549158
6Renal cell carcinoma_Homo sapiens_hsa052111.54221978
7Antigen processing and presentation_Homo sapiens_hsa046121.54027145
8Osteoclast differentiation_Homo sapiens_hsa043801.53979719
9Transcriptional misregulation in cancer_Homo sapiens_hsa052021.53860067
10Adherens junction_Homo sapiens_hsa045201.53850507
11Chronic myeloid leukemia_Homo sapiens_hsa052201.53294906
12MicroRNAs in cancer_Homo sapiens_hsa052061.52429323
13Herpes simplex infection_Homo sapiens_hsa051681.40479103
14Small cell lung cancer_Homo sapiens_hsa052221.38981076
15T cell receptor signaling pathway_Homo sapiens_hsa046601.33551247
16Measles_Homo sapiens_hsa051621.32950180
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31038035
18Type II diabetes mellitus_Homo sapiens_hsa049301.30642676
19Toxoplasmosis_Homo sapiens_hsa051451.29783612
20Thyroid cancer_Homo sapiens_hsa052161.26448739
21Leishmaniasis_Homo sapiens_hsa051401.23895701
22mTOR signaling pathway_Homo sapiens_hsa041501.23784039
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22131438
24Influenza A_Homo sapiens_hsa051641.20830092
25Dorso-ventral axis formation_Homo sapiens_hsa043201.20444297
26Acute myeloid leukemia_Homo sapiens_hsa052211.17556450
27Pancreatic cancer_Homo sapiens_hsa052121.17008163
28mRNA surveillance pathway_Homo sapiens_hsa030151.16377917
29Prostate cancer_Homo sapiens_hsa052151.15266036
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15248455
31ErbB signaling pathway_Homo sapiens_hsa040121.15115124
32Insulin resistance_Homo sapiens_hsa049311.15056366
33Notch signaling pathway_Homo sapiens_hsa043301.14274176
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12277789
35Circadian rhythm_Homo sapiens_hsa047101.11671093
36Proteoglycans in cancer_Homo sapiens_hsa052051.10627221
37Hematopoietic cell lineage_Homo sapiens_hsa046401.10553043
38Viral carcinogenesis_Homo sapiens_hsa052031.09686017
39HTLV-I infection_Homo sapiens_hsa051661.09325671
40Hepatitis B_Homo sapiens_hsa051611.06891870
41VEGF signaling pathway_Homo sapiens_hsa043701.06364866
42One carbon pool by folate_Homo sapiens_hsa006701.06287573
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.03471846
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.02858400
45Basal transcription factors_Homo sapiens_hsa030221.01762195
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01612412
47FoxO signaling pathway_Homo sapiens_hsa040681.01575740
48Cell cycle_Homo sapiens_hsa041101.01234777
49Viral myocarditis_Homo sapiens_hsa054160.98331833
50Non-small cell lung cancer_Homo sapiens_hsa052230.97858633
51Colorectal cancer_Homo sapiens_hsa052100.97728082
52Inositol phosphate metabolism_Homo sapiens_hsa005620.97561979
53TNF signaling pathway_Homo sapiens_hsa046680.94788860
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93850377
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93797782
56Fatty acid biosynthesis_Homo sapiens_hsa000610.93224740
57Endometrial cancer_Homo sapiens_hsa052130.92226500
58Platelet activation_Homo sapiens_hsa046110.92047893
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89940048
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89011558
61Fanconi anemia pathway_Homo sapiens_hsa034600.88915589
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88811446
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88030851
64Focal adhesion_Homo sapiens_hsa045100.87894342
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86550012
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.85944390
67Apoptosis_Homo sapiens_hsa042100.83904476
68TGF-beta signaling pathway_Homo sapiens_hsa043500.81951578
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.81051931
70Prolactin signaling pathway_Homo sapiens_hsa049170.79366420
71Linoleic acid metabolism_Homo sapiens_hsa005910.78883238
72Systemic lupus erythematosus_Homo sapiens_hsa053220.78289768
73Chemokine signaling pathway_Homo sapiens_hsa040620.77617506
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76897283
75Mismatch repair_Homo sapiens_hsa034300.76785506
76Insulin signaling pathway_Homo sapiens_hsa049100.76497392
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76324408
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76045062
79Pathways in cancer_Homo sapiens_hsa052000.75578426
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75008770
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74350348
82p53 signaling pathway_Homo sapiens_hsa041150.73214495
83Basal cell carcinoma_Homo sapiens_hsa052170.73111933
84ABC transporters_Homo sapiens_hsa020100.71586093
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71056833
86Hepatitis C_Homo sapiens_hsa051600.70816859
87Selenocompound metabolism_Homo sapiens_hsa004500.70651480
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.66986236
89Tuberculosis_Homo sapiens_hsa051520.66454831
90ECM-receptor interaction_Homo sapiens_hsa045120.66178897
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66005863
92RNA degradation_Homo sapiens_hsa030180.65373398
93Legionellosis_Homo sapiens_hsa051340.65057504
94Autoimmune thyroid disease_Homo sapiens_hsa053200.64406041
95RNA transport_Homo sapiens_hsa030130.64298882
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63422756
97Glucagon signaling pathway_Homo sapiens_hsa049220.63104345
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61163184
99Estrogen signaling pathway_Homo sapiens_hsa049150.60547017
100Glioma_Homo sapiens_hsa052140.60346802
101Graft-versus-host disease_Homo sapiens_hsa053320.60185867
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.59755117
103AMPK signaling pathway_Homo sapiens_hsa041520.59331771
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59085738
105Epstein-Barr virus infection_Homo sapiens_hsa051690.58751824
106GnRH signaling pathway_Homo sapiens_hsa049120.57633778
107Amoebiasis_Homo sapiens_hsa051460.57629080
108Choline metabolism in cancer_Homo sapiens_hsa052310.55646818
109Melanoma_Homo sapiens_hsa052180.55555338
110HIF-1 signaling pathway_Homo sapiens_hsa040660.55527865
111Wnt signaling pathway_Homo sapiens_hsa043100.54515063
112Homologous recombination_Homo sapiens_hsa034400.53718715
113Base excision repair_Homo sapiens_hsa034100.53324834
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.52027549
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51418235
116Staphylococcus aureus infection_Homo sapiens_hsa051500.51414797
117MAPK signaling pathway_Homo sapiens_hsa040100.51359376
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50252712
119Rap1 signaling pathway_Homo sapiens_hsa040150.50231191
120Spliceosome_Homo sapiens_hsa030400.49955712
121Allograft rejection_Homo sapiens_hsa053300.48484992
122Type I diabetes mellitus_Homo sapiens_hsa049400.47730158
123Thyroid hormone synthesis_Homo sapiens_hsa049180.46470122
124Asthma_Homo sapiens_hsa053100.46469588
125Ether lipid metabolism_Homo sapiens_hsa005650.44618583
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.43134613
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41642709
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40858236

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