ANKLE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)5.40910405
2DNA strand elongation involved in DNA replication (GO:0006271)5.12812034
3protein localization to kinetochore (GO:0034501)5.03970989
4kinetochore organization (GO:0051383)5.00552739
5tachykinin receptor signaling pathway (GO:0007217)4.98136637
6DNA strand elongation (GO:0022616)4.97166719
7telomere maintenance via recombination (GO:0000722)4.83400623
8mitotic recombination (GO:0006312)4.68064379
9kinetochore assembly (GO:0051382)4.63483008
10CENP-A containing nucleosome assembly (GO:0034080)4.63282431
11protein localization to chromosome, centromeric region (GO:0071459)4.61828441
12DNA replication initiation (GO:0006270)4.53125572
13behavioral response to nicotine (GO:0035095)4.52500285
14DNA replication checkpoint (GO:0000076)4.46930179
15mitotic sister chromatid segregation (GO:0000070)4.46499951
16chromatin remodeling at centromere (GO:0031055)4.43501697
17indolalkylamine metabolic process (GO:0006586)4.41265451
18regulation of DNA endoreduplication (GO:0032875)4.36319986
19meiotic chromosome segregation (GO:0045132)4.34409445
20L-fucose catabolic process (GO:0042355)4.28619672
21fucose catabolic process (GO:0019317)4.28619672
22L-fucose metabolic process (GO:0042354)4.28619672
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.27665785
24attachment of spindle microtubules to kinetochore (GO:0008608)4.27136616
25daunorubicin metabolic process (GO:0044597)4.26356000
26polyketide metabolic process (GO:0030638)4.26356000
27doxorubicin metabolic process (GO:0044598)4.26356000
28telomere maintenance via telomere lengthening (GO:0010833)4.26240897
29sister chromatid segregation (GO:0000819)4.11392671
30nucleotide-excision repair, DNA gap filling (GO:0006297)4.07194334
31DNA unwinding involved in DNA replication (GO:0006268)4.07010032
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.03919047
33DNA replication-independent nucleosome assembly (GO:0006336)4.03516892
34DNA replication-independent nucleosome organization (GO:0034724)4.03516892
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.97459371
36DNA deamination (GO:0045006)3.97220088
37indole-containing compound catabolic process (GO:0042436)3.91794965
38indolalkylamine catabolic process (GO:0046218)3.91794965
39tryptophan catabolic process (GO:0006569)3.91794965
40detection of light stimulus involved in visual perception (GO:0050908)3.86805474
41detection of light stimulus involved in sensory perception (GO:0050962)3.86805474
42mitotic metaphase plate congression (GO:0007080)3.86711524
43mitotic chromosome condensation (GO:0007076)3.72803319
44kynurenine metabolic process (GO:0070189)3.65951342
45ribosomal small subunit assembly (GO:0000028)3.65662113
46neural tube formation (GO:0001841)3.64900880
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.64060802
48tryptophan metabolic process (GO:0006568)3.63322452
49piRNA metabolic process (GO:0034587)3.61174128
50metaphase plate congression (GO:0051310)3.60455456
51translesion synthesis (GO:0019985)3.47684470
52protein K11-linked deubiquitination (GO:0035871)3.47098427
53protoporphyrinogen IX metabolic process (GO:0046501)3.44933359
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.44298177
55establishment of chromosome localization (GO:0051303)3.43349888
56histone exchange (GO:0043486)3.43020715
57positive regulation of developmental pigmentation (GO:0048087)3.42312620
58positive regulation of DNA-dependent DNA replication (GO:2000105)3.38879698
59response to pheromone (GO:0019236)3.38346055
60telomere maintenance (GO:0000723)3.37843905
61DNA synthesis involved in DNA repair (GO:0000731)3.35522706
62telomere organization (GO:0032200)3.34550504
63negative regulation of mast cell activation (GO:0033004)3.34211608
64negative regulation of DNA-dependent DNA replication (GO:2000104)3.33505661
65protoporphyrinogen IX biosynthetic process (GO:0006782)3.31682647
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30138794
67regulation of spindle organization (GO:0090224)3.28132024
68reflex (GO:0060004)3.26003157
69cilium or flagellum-dependent cell motility (GO:0001539)3.25842248
70mitotic nuclear envelope disassembly (GO:0007077)3.24597281
71DNA topological change (GO:0006265)3.23897835
72NAD biosynthetic process (GO:0009435)3.23057479
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22435120
74deoxyribonucleotide biosynthetic process (GO:0009263)3.20081840
75cellular ketone body metabolic process (GO:0046950)3.19682333
76chromosome segregation (GO:0007059)3.19464714
77spindle checkpoint (GO:0031577)3.19452352
78spindle assembly checkpoint (GO:0071173)3.17358184
79protein localization to chromosome (GO:0034502)3.17155570
80indole-containing compound metabolic process (GO:0042430)3.16110809
81mitotic sister chromatid cohesion (GO:0007064)3.14623460
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14570805
83double-strand break repair via homologous recombination (GO:0000724)3.14230327
84adaptation of signaling pathway (GO:0023058)3.13936336
85recombinational repair (GO:0000725)3.13503106
86auditory receptor cell stereocilium organization (GO:0060088)3.13204645
87DNA catabolic process, exonucleolytic (GO:0000738)3.12234303
88negative regulation of RNA splicing (GO:0033119)3.11433761
89mismatch repair (GO:0006298)3.10487338
90DNA strand renaturation (GO:0000733)3.10293779
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09647049
92negative regulation of chromosome segregation (GO:0051985)3.09548261
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.09013485
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09013485
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09013485
96negative regulation of sister chromatid segregation (GO:0033046)3.09013485
97regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05989122
98DNA replication-dependent nucleosome organization (GO:0034723)3.02215962
99DNA replication-dependent nucleosome assembly (GO:0006335)3.02215962
100behavioral response to ethanol (GO:0048149)3.01488771
101protein K6-linked ubiquitination (GO:0085020)3.01209311
102DNA methylation involved in gamete generation (GO:0043046)3.00615901
103DNA double-strand break processing (GO:0000729)3.00385828
104chromatin assembly or disassembly (GO:0006333)3.00079028
105heme biosynthetic process (GO:0006783)2.99518900
106regulation of mitotic spindle checkpoint (GO:1903504)2.98423922
107regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98423922
108photoreceptor cell maintenance (GO:0045494)2.98233929
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97668282
110regulation of DNA-dependent DNA replication (GO:0090329)2.97329927
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97291110
112base-excision repair (GO:0006284)2.96780563
113regulation of chromosome segregation (GO:0051983)2.96693070
114microtubule depolymerization (GO:0007019)2.96451990
115mitotic spindle assembly checkpoint (GO:0007094)2.95394542
116regulation of centrosome cycle (GO:0046605)2.93809802
117DNA ligation (GO:0006266)2.91975291
118regulation of sister chromatid segregation (GO:0033045)2.91123717
119regulation of mitotic sister chromatid separation (GO:0010965)2.91123717
120regulation of mitotic sister chromatid segregation (GO:0033047)2.91123717
121negative regulation of mRNA processing (GO:0050686)2.90679006
122axoneme assembly (GO:0035082)2.89871923
123membrane disassembly (GO:0030397)2.89862211
124nuclear envelope disassembly (GO:0051081)2.89862211
125dopamine transport (GO:0015872)2.89791255
126regulation of double-strand break repair via homologous recombination (GO:0010569)2.88499261
127regulation of hippo signaling (GO:0035330)2.87033413
128DNA replication (GO:0006260)2.86756031
129cornea development in camera-type eye (GO:0061303)2.86711148
130ATP-dependent chromatin remodeling (GO:0043044)2.84808266
131reciprocal meiotic recombination (GO:0007131)2.84685346
132reciprocal DNA recombination (GO:0035825)2.84685346
133ketone body metabolic process (GO:1902224)2.84243339
134viral mRNA export from host cell nucleus (GO:0046784)2.83682985
135disruption of cells of other organism (GO:0044364)2.83014262
136killing of cells of other organism (GO:0031640)2.83014262
137postreplication repair (GO:0006301)2.82608461
138replication fork processing (GO:0031297)2.81239024
139serotonin metabolic process (GO:0042428)2.81170552
140signal peptide processing (GO:0006465)2.80553867
141intra-S DNA damage checkpoint (GO:0031573)2.78802139
142DNA geometric change (GO:0032392)2.77787821
143IMP biosynthetic process (GO:0006188)2.77787272
144monoubiquitinated protein deubiquitination (GO:0035520)2.77205215
145sulfation (GO:0051923)2.76819609
146DNA duplex unwinding (GO:0032508)2.76287226
147primary amino compound metabolic process (GO:1901160)2.75208019
148amine catabolic process (GO:0009310)2.72337519
149cellular biogenic amine catabolic process (GO:0042402)2.72337519
150negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69980561
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68331448
152protein-cofactor linkage (GO:0018065)2.65941108
153centriole replication (GO:0007099)2.64310183
154gamma-aminobutyric acid transport (GO:0015812)2.64301990
155glycine transport (GO:0015816)2.63628156
156rRNA catabolic process (GO:0016075)2.63441996
157protein polyglutamylation (GO:0018095)2.58737205
158nonmotile primary cilium assembly (GO:0035058)2.57786554
159regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57756559
160tetrapyrrole biosynthetic process (GO:0033014)2.57133976
161histone H3-K9 methylation (GO:0051567)2.53392631
162protein localization to cilium (GO:0061512)2.53378754
163porphyrin-containing compound biosynthetic process (GO:0006779)2.53149238
164inner ear receptor stereocilium organization (GO:0060122)2.52840796
165retinal cone cell development (GO:0046549)2.52520874
166ubiquinone biosynthetic process (GO:0006744)2.52517263
167rhodopsin mediated signaling pathway (GO:0016056)2.51956186
168positive regulation of digestive system process (GO:0060456)2.51732345
169ubiquinone metabolic process (GO:0006743)2.49244938
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49185255
171proline transport (GO:0015824)2.47610817
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46930546
173protein K48-linked deubiquitination (GO:0071108)2.46297933
174negative regulation of calcium ion transport into cytosol (GO:0010523)2.46250060
175DNA integration (GO:0015074)2.45949178
176mitochondrial respiratory chain complex I assembly (GO:0032981)2.44600256
177NADH dehydrogenase complex assembly (GO:0010257)2.44600256
178mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44600256
179synapsis (GO:0007129)2.44047779
180positive regulation of defense response to virus by host (GO:0002230)2.42862423
181respiratory chain complex IV assembly (GO:0008535)2.42199706
182detection of mechanical stimulus involved in sensory perception (GO:0050974)2.41506692
183positive regulation of granulocyte differentiation (GO:0030854)2.40810368
184snRNA transcription (GO:0009301)2.38315132
185negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36665596
186negative regulation of translation, ncRNA-mediated (GO:0040033)2.36665596
187regulation of translation, ncRNA-mediated (GO:0045974)2.36665596
188cilium morphogenesis (GO:0060271)2.36424199
189righting reflex (GO:0060013)2.36258563
190cell wall macromolecule metabolic process (GO:0044036)2.35199246
191negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34786696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.21478194
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.97745410
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.17888009
4ZNF274_21170338_ChIP-Seq_K562_Hela3.63649774
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.39088331
6VDR_22108803_ChIP-Seq_LS180_Human3.38667617
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20494598
8IGF1R_20145208_ChIP-Seq_DFB_Human3.04927283
9GBX2_23144817_ChIP-Seq_PC3_Human3.01792938
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97319609
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86627445
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76152483
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56280553
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.49699993
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49154145
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46930241
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38903709
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.38570001
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33946190
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30791643
21TAF15_26573619_Chip-Seq_HEK293_Human2.29203784
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.27350200
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24283041
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23005383
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21618049
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20767756
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.18455143
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17942731
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15699043
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14188658
31AR_21909140_ChIP-Seq_LNCAP_Human2.11899302
32EZH2_22144423_ChIP-Seq_EOC_Human2.06891649
33VDR_23849224_ChIP-Seq_CD4+_Human2.04831341
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.03164082
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03137324
36CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02228408
37GABP_17652178_ChIP-ChIP_JURKAT_Human2.00841775
38E2F7_22180533_ChIP-Seq_HELA_Human11.5578822
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98694501
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.97531774
41GATA1_22025678_ChIP-Seq_K562_Human1.96504694
42FUS_26573619_Chip-Seq_HEK293_Human1.95493944
43P300_19829295_ChIP-Seq_ESCs_Human1.94156633
44FOXP3_21729870_ChIP-Seq_TREG_Human1.94012497
45ER_23166858_ChIP-Seq_MCF-7_Human1.93083717
46XRN2_22483619_ChIP-Seq_HELA_Human1.84680169
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84329860
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82046601
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81431296
50CIITA_25753668_ChIP-Seq_RAJI_Human1.80202606
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77209597
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76720413
53STAT3_23295773_ChIP-Seq_U87_Human1.76409879
54SCL_19346495_ChIP-Seq_HPC-7_Human1.75429398
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74901167
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72765133
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72679718
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71469044
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70148051
60DCP1A_22483619_ChIP-Seq_HELA_Human1.70124332
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69736287
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68681829
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66597005
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65558896
65CBP_20019798_ChIP-Seq_JUKART_Human1.64101551
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64101551
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64037186
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63817608
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63784473
70TP53_22573176_ChIP-Seq_HFKS_Human1.61730516
71TCF4_23295773_ChIP-Seq_U87_Human1.61656896
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61217726
73* MYC_22102868_ChIP-Seq_BL_Human1.61054612
74TTF2_22483619_ChIP-Seq_HELA_Human1.60687921
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59376232
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58351111
77ELK1_19687146_ChIP-ChIP_HELA_Human1.58003800
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.56083386
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54063666
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52298274
81VDR_21846776_ChIP-Seq_THP-1_Human1.51433450
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51297563
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51297563
84BCAT_22108803_ChIP-Seq_LS180_Human1.50899645
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49755999
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49626913
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.49560280
88AR_21572438_ChIP-Seq_LNCaP_Human1.48878559
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47674160
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.45859212
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45436374
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45185866
93SMAD4_21799915_ChIP-Seq_A2780_Human1.44838686
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44628589
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44437427
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43603643
97GABP_19822575_ChIP-Seq_HepG2_Human1.42189197
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41186798
99AR_25329375_ChIP-Seq_VCAP_Human1.35534232
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34721005
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33651740
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.31313263
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31186538
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30666934
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28937062
106* NANOG_19829295_ChIP-Seq_ESCs_Human1.28576199
107* SOX2_19829295_ChIP-Seq_ESCs_Human1.28576199
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.28499190
109TCF4_22108803_ChIP-Seq_LS180_Human1.26260731
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24088507
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23695461
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.23585734
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23554749
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.23112097
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22352767
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21744127
117* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21254490
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.20565898
119FOXA1_25329375_ChIP-Seq_VCAP_Human1.20287900
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20287900
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19869953
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19259809
123REST_21632747_ChIP-Seq_MESCs_Mouse1.18475667
124KDM5A_27292631_Chip-Seq_BREAST_Human1.18386468
125RUNX2_22187159_ChIP-Seq_PCA_Human1.18256047
126* SPI1_23547873_ChIP-Seq_NB4_Human1.17555398
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17121679
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.16989393
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16437463
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.13222939
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11143452
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09567171
133SMAD4_21741376_ChIP-Seq_EPCs_Human1.09477300
134EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09224498
135NCOR_22424771_ChIP-Seq_293T_Human1.07791660
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07601893
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06322092
138GATA3_21878914_ChIP-Seq_MCF-7_Human1.05289718
139IRF8_22096565_ChIP-ChIP_GC-B_Human1.05120484
140CRX_20693478_ChIP-Seq_RETINA_Mouse1.03924767
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03819551
142AR_20517297_ChIP-Seq_VCAP_Human1.03427939
143PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02923121
144GATA3_26560356_Chip-Seq_TH2_Human1.02511103
145HOXB7_26014856_ChIP-Seq_BT474_Human1.02134501
146AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01990060
147E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01902231
148CDX2_22108803_ChIP-Seq_LS180_Human1.01777438
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01145280
150ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00991620
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00319511
152MYC_18940864_ChIP-ChIP_HL60_Human0.99053766
153SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98174462
154TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97877352
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97534580
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.96266182
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95444041
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95170821
159OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94972317
160RNF2_27304074_Chip-Seq_NSC_Mouse0.94875933
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94874517
162GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94853903
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94618955
164SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93704388
165CBX2_27304074_Chip-Seq_ESCs_Mouse0.90560740
166STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86442822
167RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85819451
168IRF8_21731497_ChIP-ChIP_J774_Mouse0.85566307
169KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85018908
170POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83306097
171CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82340708
172IRF1_19129219_ChIP-ChIP_H3396_Human0.81285589
173MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80751798
174GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77999977
175TFEB_21752829_ChIP-Seq_HELA_Human0.77746666
176MYB_26560356_Chip-Seq_TH1_Human0.76141428
177TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74282318
178ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74156301
179POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74047980
180MYB_26560356_Chip-Seq_TH2_Human0.73662304
181PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73334760
182RUNX1_22412390_ChIP-Seq_EML_Mouse0.72644959
183BP1_19119308_ChIP-ChIP_Hs578T_Human0.72004230
184RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70660575
185VDR_24763502_ChIP-Seq_THP-1_Human0.68277881
186EWS_26573619_Chip-Seq_HEK293_Human0.67341062
187FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66179954
188LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.65061964
189GATA1_19941827_ChIP-Seq_MEL_Mouse0.65006408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.81208845
2MP0010094_abnormal_chromosome_stability4.62191221
3MP0003111_abnormal_nucleus_morphology4.51357363
4MP0008057_abnormal_DNA_replication3.64961830
5MP0003077_abnormal_cell_cycle3.49712165
6MP0002396_abnormal_hematopoietic_system3.41943667
7MP0008058_abnormal_DNA_repair3.22844641
8MP0003195_calcinosis3.01172066
9MP0004957_abnormal_blastocyst_morpholog2.83169804
10MP0004147_increased_porphyrin_level2.63621160
11MP0008007_abnormal_cellular_replicative2.52004409
12MP0003656_abnormal_erythrocyte_physiolo2.49223598
13MP0001968_abnormal_touch/_nociception2.36876348
14MP0000372_irregular_coat_pigmentation2.31705817
15MP0005551_abnormal_eye_electrophysiolog2.28159731
16MP0009046_muscle_twitch2.22462894
17MP0003646_muscle_fatigue2.20056540
18MP0006292_abnormal_olfactory_placode2.17892879
19MP0000490_abnormal_crypts_of2.17372420
20MP0001501_abnormal_sleep_pattern2.15503799
21MP0002736_abnormal_nociception_after2.03550807
22MP0006276_abnormal_autonomic_nervous2.01855881
23MP0002638_abnormal_pupillary_reflex2.00092461
24MP0002132_abnormal_respiratory_system1.98305409
25MP0008872_abnormal_physiological_respon1.93602782
26MP0008932_abnormal_embryonic_tissue1.93470759
27MP0003136_yellow_coat_color1.93167989
28MP0001545_abnormal_hematopoietic_system1.91358124
29MP0005397_hematopoietic_system_phenotyp1.91358124
30MP0005174_abnormal_tail_pigmentation1.86782505
31MP0000569_abnormal_digit_pigmentation1.81074794
32MP0004808_abnormal_hematopoietic_stem1.76544912
33MP0003786_premature_aging1.75817633
34MP0005646_abnormal_pituitary_gland1.71672200
35MP0000566_synostosis1.69929691
36MP0009745_abnormal_behavioral_response1.69440319
37MP0002735_abnormal_chemical_nociception1.68670248
38MP0000015_abnormal_ear_pigmentation1.64752864
39MP0009697_abnormal_copulation1.61823898
40MP0002398_abnormal_bone_marrow1.56941290
41MP0005253_abnormal_eye_physiology1.56720620
42MP0002095_abnormal_skin_pigmentation1.55129945
43MP0004043_abnormal_pH_regulation1.52320232
44MP0005075_abnormal_melanosome_morpholog1.47643977
45MP0000350_abnormal_cell_proliferation1.46598089
46MP0003121_genomic_imprinting1.46592441
47MP0000703_abnormal_thymus_morphology1.41848225
48MP0003718_maternal_effect1.41348218
49MP0001835_abnormal_antigen_presentation1.37260159
50MP0002837_dystrophic_cardiac_calcinosis1.37229325
51MP0005671_abnormal_response_to1.36449709
52MP0008877_abnormal_DNA_methylation1.35595855
53MP0002722_abnormal_immune_system1.34659842
54MP0010307_abnormal_tumor_latency1.34522397
55MP0005083_abnormal_biliary_tract1.34174377
56MP0004742_abnormal_vestibular_system1.34038882
57MP0003787_abnormal_imprinting1.32727940
58MP0009333_abnormal_splenocyte_physiolog1.31790654
59MP0002138_abnormal_hepatobiliary_system1.31717425
60MP0000313_abnormal_cell_death1.30751806
61MP0004145_abnormal_muscle_electrophysio1.30361236
62MP0002876_abnormal_thyroid_physiology1.29463105
63MP0000689_abnormal_spleen_morphology1.28736530
64MP0004142_abnormal_muscle_tone1.24363005
65MP0003763_abnormal_thymus_physiology1.22315421
66MP0002733_abnormal_thermal_nociception1.21948885
67MP0002019_abnormal_tumor_incidence1.21840357
68MP0005310_abnormal_salivary_gland1.20849259
69MP0002163_abnormal_gland_morphology1.20140704
70MP0002277_abnormal_respiratory_mucosa1.19216137
71MP0001970_abnormal_pain_threshold1.18636702
72MP0006072_abnormal_retinal_apoptosis1.18595902
73MP0002429_abnormal_blood_cell1.18112609
74MP0002272_abnormal_nervous_system1.17942128
75MP0002938_white_spotting1.17507319
76MP0002653_abnormal_ependyma_morphology1.17355210
77MP0005410_abnormal_fertilization1.15492910
78MP0001529_abnormal_vocalization1.15277837
79MP0001485_abnormal_pinna_reflex1.15122402
80MP0005171_absent_coat_pigmentation1.14547516
81MP0000427_abnormal_hair_cycle1.14254165
82MP0001188_hyperpigmentation1.13095796
83MP0001486_abnormal_startle_reflex1.12546657
84MP0000631_abnormal_neuroendocrine_gland1.12506164
85MP0001800_abnormal_humoral_immune1.12352450
86MP0003045_fibrosis1.10207255
87MP0010386_abnormal_urinary_bladder1.09882397
88MP0003698_abnormal_male_reproductive1.09482305
89MP0005645_abnormal_hypothalamus_physiol1.08737180
90MP0003941_abnormal_skin_development1.06965745
91MP0002572_abnormal_emotion/affect_behav1.06854404
92MP0009278_abnormal_bone_marrow1.06806021
93MP0000716_abnormal_immune_system1.06662350
94MP0002102_abnormal_ear_morphology1.04480771
95MP0004924_abnormal_behavior1.03759295
96MP0005386_behavior/neurological_phenoty1.03759295
97MP0005670_abnormal_white_adipose1.03444647
98MP0003123_paternal_imprinting1.03310146
99MP0002075_abnormal_coat/hair_pigmentati1.02898114
100MP0002928_abnormal_bile_duct1.02753227
101MP0002420_abnormal_adaptive_immunity1.01711162
102MP0001819_abnormal_immune_cell1.00846501
103MP0006054_spinal_hemorrhage1.00665002
104MP0002452_abnormal_antigen_presenting1.00208957
105MP0001730_embryonic_growth_arrest0.99243435
106MP0000685_abnormal_immune_system0.97903024
107MP0001186_pigmentation_phenotype0.96760000
108MP0002064_seizures0.95442842
109MP0002229_neurodegeneration0.95304368
110MP0002067_abnormal_sensory_capabilities0.95021548
111MP0001764_abnormal_homeostasis0.94677423
112MP0001293_anophthalmia0.94292269
113MP0001929_abnormal_gametogenesis0.93937824
114MP0001984_abnormal_olfaction0.92477232
115MP0000678_abnormal_parathyroid_gland0.90623937
116MP0002723_abnormal_immune_serum0.88907066
117MP0005380_embryogenesis_phenotype0.88623738
118MP0001672_abnormal_embryogenesis/_devel0.88623738
119MP0002693_abnormal_pancreas_physiology0.87325713
120MP0003878_abnormal_ear_physiology0.86790588
121MP0005377_hearing/vestibular/ear_phenot0.86790588
122MP0002080_prenatal_lethality0.84902095
123MP0003635_abnormal_synaptic_transmissio0.83842661
124MP0001324_abnormal_eye_pigmentation0.83520247
125MP0009785_altered_susceptibility_to0.83186461
126MP0005266_abnormal_metabolism0.82939719
127MP0009764_decreased_sensitivity_to0.82451925
128MP0002557_abnormal_social/conspecific_i0.82396229
129MP0005025_abnormal_response_to0.82335657
130MP0008875_abnormal_xenobiotic_pharmacok0.82299198
131MP0002210_abnormal_sex_determination0.81167983
132MP0001986_abnormal_taste_sensitivity0.81022682
133MP0000858_altered_metastatic_potential0.80919477
134MP0003567_abnormal_fetal_cardiomyocyte0.80400537
135MP0008004_abnormal_stomach_pH0.80316524
136MP0001790_abnormal_immune_system0.80271738
137MP0005387_immune_system_phenotype0.80271738
138MP0002160_abnormal_reproductive_system0.79182578
139MP0001119_abnormal_female_reproductive0.78501290
140MP0000049_abnormal_middle_ear0.78475604
141MP0003880_abnormal_central_pattern0.78076066
142MP0002085_abnormal_embryonic_tissue0.77578220
143MP0005636_abnormal_mineral_homeostasis0.77470484
144MP0002405_respiratory_system_inflammati0.77366004
145MP0001697_abnormal_embryo_size0.76516384
146MP0003984_embryonic_growth_retardation0.75769944
147MP0002751_abnormal_autonomic_nervous0.75607118
148MP0005395_other_phenotype0.74322160
149MP0002086_abnormal_extraembryonic_tissu0.74119792
150MP0004885_abnormal_endolymph0.73796783
151MP0004133_heterotaxia0.73356797
152MP0000230_abnormal_systemic_arterial0.73060863
153MP0002088_abnormal_embryonic_growth/wei0.72851191
154MP0000653_abnormal_sex_gland0.72752785
155MP0005000_abnormal_immune_tolerance0.71782425
156MP0005647_abnormal_sex_gland0.71219833
157MP0005167_abnormal_blood-brain_barrier0.70819578
158MP0000371_diluted_coat_color0.70461030
159MP0005464_abnormal_platelet_physiology0.69929938
160MP0005195_abnormal_posterior_eye0.69499843
161MP0000383_abnormal_hair_follicle0.68188439
162MP0002419_abnormal_innate_immunity0.68023393
163MP0001873_stomach_inflammation0.67022738
164MP0002148_abnormal_hypersensitivity_rea0.64459739
165MP0010030_abnormal_orbit_morphology0.62547381
166MP0003436_decreased_susceptibility_to0.61521293
167MP0008995_early_reproductive_senescence0.61268428
168MP0004197_abnormal_fetal_growth/weight/0.59626616
169MP0003943_abnormal_hepatobiliary_system0.58811641
170MP0005389_reproductive_system_phenotype0.56727379
171MP0010155_abnormal_intestine_physiology0.56626677
172MP0001919_abnormal_reproductive_system0.56217756

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.88265804
2Chromsome breakage (HP:0040012)5.76139037
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.81119924
4Pancreatic cysts (HP:0001737)4.24735514
5Attenuation of retinal blood vessels (HP:0007843)4.18285865
6Reticulocytopenia (HP:0001896)4.14298043
7Abnormality of the preputium (HP:0100587)4.06063414
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.98842461
9Hyperventilation (HP:0002883)3.97189881
10Meckel diverticulum (HP:0002245)3.95122336
11Birth length less than 3rd percentile (HP:0003561)3.90532099
12Abnormality of chromosome stability (HP:0003220)3.82817749
13Abnormality of the ileum (HP:0001549)3.81936709
14Duplicated collecting system (HP:0000081)3.80255543
15Pancreatic fibrosis (HP:0100732)3.66827226
16Congenital stationary night blindness (HP:0007642)3.65158321
17Abnormality of the renal collecting system (HP:0004742)3.59152116
18True hermaphroditism (HP:0010459)3.56862188
19Ectopic kidney (HP:0000086)3.52388122
20Abnormal number of erythroid precursors (HP:0012131)3.40210857
21Molar tooth sign on MRI (HP:0002419)3.33750019
22Abnormality of midbrain morphology (HP:0002418)3.33750019
23Small intestinal stenosis (HP:0012848)3.29539505
24Duodenal stenosis (HP:0100867)3.29539505
25Gaze-evoked nystagmus (HP:0000640)3.25492433
26Abnormality of DNA repair (HP:0003254)3.20910878
27Clubbing of toes (HP:0100760)3.20359565
28Myelodysplasia (HP:0002863)3.10292489
29Abnormality of cells of the erythroid lineage (HP:0012130)3.09540452
30Nephronophthisis (HP:0000090)3.05281716
31Abnormality of the carotid arteries (HP:0005344)2.99117823
32Genetic anticipation (HP:0003743)2.98097883
33Abnormal rod and cone electroretinograms (HP:0008323)2.87624198
34Decreased central vision (HP:0007663)2.84449098
35Abolished electroretinogram (ERG) (HP:0000550)2.83517337
36Abnormality of the renal cortex (HP:0011035)2.81442015
37Chronic hepatic failure (HP:0100626)2.79764905
38Abnormality of the renal medulla (HP:0100957)2.78744482
39Bony spicule pigmentary retinopathy (HP:0007737)2.76566905
40Bone marrow hypocellularity (HP:0005528)2.75216712
41Aplastic anemia (HP:0001915)2.73862540
42Pallor (HP:0000980)2.73497141
43Patellar aplasia (HP:0006443)2.73468889
44Progressive cerebellar ataxia (HP:0002073)2.66064004
45Cystic liver disease (HP:0006706)2.66054693
46Progressive inability to walk (HP:0002505)2.65995269
47Abnormality of the duodenum (HP:0002246)2.63128458
48Medial flaring of the eyebrow (HP:0010747)2.62941717
49Absent thumb (HP:0009777)2.61869593
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.61197865
51Clumsiness (HP:0002312)2.55742493
52Type II lissencephaly (HP:0007260)2.52758411
53Protruding tongue (HP:0010808)2.51165212
54Sloping forehead (HP:0000340)2.49554477
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46954081
56Inability to walk (HP:0002540)2.45785148
57Aplasia/Hypoplasia of the patella (HP:0006498)2.45747758
58Poikilocytosis (HP:0004447)2.45182875
59Abnormality of reticulocytes (HP:0004312)2.44559064
60Triphalangeal thumb (HP:0001199)2.41495835
61Pendular nystagmus (HP:0012043)2.40525487
62Abnormality of macular pigmentation (HP:0008002)2.39882192
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39529148
64Abnormality of alanine metabolism (HP:0010916)2.39529148
65Hyperalaninemia (HP:0003348)2.39529148
66Oral leukoplakia (HP:0002745)2.34925142
67Decreased circulating renin level (HP:0003351)2.33722403
68Nephroblastoma (Wilms tumor) (HP:0002667)2.27128644
69Cerebellar dysplasia (HP:0007033)2.25911870
70Constricted visual fields (HP:0001133)2.23900768
71Abnormal number of incisors (HP:0011064)2.20914016
72Lissencephaly (HP:0001339)2.19732125
73Abnormal biliary tract physiology (HP:0012439)2.19290824
74Bile duct proliferation (HP:0001408)2.19290824
75Abnormality of the columella (HP:0009929)2.17444050
76Prolonged bleeding time (HP:0003010)2.16886328
77Embryonal renal neoplasm (HP:0011794)2.16855338
78Premature graying of hair (HP:0002216)2.16379659
79Abnormality of B cell number (HP:0010975)2.16342815
80Breast hypoplasia (HP:0003187)2.15582556
81Short middle phalanx of the 5th finger (HP:0004220)2.15128393
82Increased corneal curvature (HP:0100692)2.14376858
83Keratoconus (HP:0000563)2.14376858
84Focal motor seizures (HP:0011153)2.14355069
85Fair hair (HP:0002286)2.13663729
86Selective tooth agenesis (HP:0001592)2.13057950
87Abnormal drinking behavior (HP:0030082)2.12640574
88Polydipsia (HP:0001959)2.12640574
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11892092
90Tracheoesophageal fistula (HP:0002575)2.11463969
91Absent speech (HP:0001344)2.11149740
92Type I transferrin isoform profile (HP:0003642)2.09988748
93Stomach cancer (HP:0012126)2.06960003
94Optic nerve coloboma (HP:0000588)2.05752812
95Gait imbalance (HP:0002141)2.04793597
96Congenital primary aphakia (HP:0007707)2.04260511
97Petechiae (HP:0000967)2.03827725
98Tubular atrophy (HP:0000092)2.02241791
99Nephrogenic diabetes insipidus (HP:0009806)2.00686779
100Leukopenia (HP:0001882)2.00191376
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.99746613
102Poikiloderma (HP:0001029)1.99711337
103Sclerocornea (HP:0000647)1.99093034
104Short thumb (HP:0009778)1.98906394
105Dialeptic seizures (HP:0011146)1.98888824
106Prostate neoplasm (HP:0100787)1.97584425
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97369108
108Chorioretinal atrophy (HP:0000533)1.96369914
109Cheilitis (HP:0100825)1.96101870
110Absent radius (HP:0003974)1.96100967
111Unilateral renal agenesis (HP:0000122)1.95505819
112Acute lymphatic leukemia (HP:0006721)1.94941054
113Febrile seizures (HP:0002373)1.93574396
114Arteriovenous malformation (HP:0100026)1.93300623
115Broad-based gait (HP:0002136)1.92268019
116Congenital hepatic fibrosis (HP:0002612)1.91761118
117Hypochromic microcytic anemia (HP:0004840)1.91229111
118Microvesicular hepatic steatosis (HP:0001414)1.91171895
119Increased nuchal translucency (HP:0010880)1.91150692
120Horseshoe kidney (HP:0000085)1.90920786
121Anencephaly (HP:0002323)1.90757169
122Lymphoma (HP:0002665)1.90418234
123Hypoplasia of the pons (HP:0012110)1.89918509
124Volvulus (HP:0002580)1.89726467
125Impulsivity (HP:0100710)1.89173228
126Furrowed tongue (HP:0000221)1.88773719
127Abnormality of the fingertips (HP:0001211)1.87669582
128Abnormality of the pons (HP:0007361)1.87605714
129Colon cancer (HP:0003003)1.85536814
130Duplication of thumb phalanx (HP:0009942)1.85042583
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.83779087
132Renal cortical cysts (HP:0000803)1.82964262
133Large for gestational age (HP:0001520)1.82453177
134Absent forearm bone (HP:0003953)1.82126543
135Aplasia involving forearm bones (HP:0009822)1.82126543
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.81627473
137Cafe-au-lait spot (HP:0000957)1.81282789
138Congenital sensorineural hearing impairment (HP:0008527)1.80584501
139Small hand (HP:0200055)1.80375705
140Oligohydramnios (HP:0001562)1.79847481
141Pancytopenia (HP:0001876)1.79621958
142Widely spaced teeth (HP:0000687)1.78747398
143Rough bone trabeculation (HP:0100670)1.77764309
144Cleft eyelid (HP:0000625)1.76870313
145Polyuria (HP:0000103)1.76625301
14611 pairs of ribs (HP:0000878)1.76549717
147Agnosia (HP:0010524)1.76536492
148Macular degeneration (HP:0000608)1.76503076
149Severe visual impairment (HP:0001141)1.76473608
150Long eyelashes (HP:0000527)1.76463448
151Genital tract atresia (HP:0001827)1.76374507
152Abnormal lung lobation (HP:0002101)1.75490154
153Panhypogammaglobulinemia (HP:0003139)1.75233182
154Recurrent cutaneous fungal infections (HP:0011370)1.74982485
155Chronic mucocutaneous candidiasis (HP:0002728)1.74982485
156Hypergonadotropic hypogonadism (HP:0000815)1.74806981
157Microretrognathia (HP:0000308)1.74588855
158Recurrent abscess formation (HP:0002722)1.73379048
159Osteomalacia (HP:0002749)1.73070710
160Abnormality of dental color (HP:0011073)1.72482660
161Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72209664
162Cutaneous photosensitivity (HP:0000992)1.72058015
163Convex nasal ridge (HP:0000444)1.71937388
164Prominent nose (HP:0000448)1.71630102
165Hemiparesis (HP:0001269)1.71204114
166Astigmatism (HP:0000483)1.69781121
167Focal seizures (HP:0007359)1.69628179
168Retinitis pigmentosa (HP:0000510)1.68730766
169Vaginal atresia (HP:0000148)1.68305119
170Thyroid-stimulating hormone excess (HP:0002925)1.67279567
171Hypopigmented skin patches (HP:0001053)1.66847166
172Abnormal delayed hypersensitivity skin test (HP:0002963)1.66734519
173Intestinal atresia (HP:0011100)1.66261375
174Chronic otitis media (HP:0000389)1.66219613
175Thrombocytosis (HP:0001894)1.65149371
176Male pseudohermaphroditism (HP:0000037)1.65047720
177Central scotoma (HP:0000603)1.64877755
178Medulloblastoma (HP:0002885)1.64747875
179Macrocytic anemia (HP:0001972)1.63007170
180Cellular immunodeficiency (HP:0005374)1.62139385
181Abnormality of the prostate (HP:0008775)1.60541179
182IgM deficiency (HP:0002850)1.60390319
183Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59763825
184Absent epiphyses (HP:0010577)1.59763825
185Type 2 muscle fiber atrophy (HP:0003554)1.57271557
186Abnormality of the incisor (HP:0000676)1.54426275
187Slender long bone (HP:0003100)1.54371409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.67404053
2CDC74.04143138
3BUB13.43820900
4NEK23.43089519
5EIF2AK12.99994935
6SIK32.94280898
7WEE12.80959062
8MAP4K22.63302857
9CCNB12.48319081
10BMPR1B2.46925502
11WNK32.36054085
12STK162.35849438
13VRK12.33643855
14ZAK2.28434469
15SRPK12.26495556
16TTK2.21515613
17TLK12.09262872
18INSRR2.07026229
19STK41.97364902
20ATR1.93396720
21MKNK21.92566668
22NME21.90744152
23MKNK11.86754100
24TAOK31.85970867
25PLK11.84593375
26MAP3K41.83315249
27AURKB1.76110257
28CDK81.71647156
29GRK11.65695120
30ACVR1B1.62885865
31PLK41.62489785
32CHEK21.61087661
33BRD41.59794984
34CDK71.57056546
35PIK3CG1.50713567
36BRSK21.48545325
37PINK11.47328138
38CDK41.46830487
39EIF2AK21.46242414
40SIK21.44906930
41IRAK31.44647671
42BRSK11.43981600
43IRAK41.43785706
44OXSR11.43534678
45DYRK31.33318976
46CDK121.33114199
47EIF2AK31.21214731
48WNK41.19316416
49CLK11.17326239
50MAP3K101.15499153
51STK101.14794450
52YES11.13666611
53TNK21.11691360
54RPS6KA41.10368241
55PLK31.06638906
56CASK1.06406863
57BCKDK1.05915661
58CHEK11.05611933
59ADRBK11.05287154
60STK391.04968492
61PASK1.04120484
62MAP4K11.02745608
63IRAK11.01138145
64TXK0.99783972
65VRK20.99540209
66ATM0.98518078
67TRIM280.98006769
68TEC0.95708117
69DAPK20.95420914
70AURKA0.95095729
71STK38L0.94439479
72KIT0.91171294
73CSNK1G30.90425875
74MARK30.87092322
75MAP2K70.86120432
76MAP3K80.85437332
77PIM10.84248186
78CSNK1G20.82577103
79TSSK60.82437186
80EEF2K0.80762230
81CSNK1G10.79093780
82RPS6KB20.78843802
83TAF10.78495607
84CSNK1A1L0.78484299
85NEK10.76925508
86PTK2B0.75163845
87PAK40.74077262
88TAOK20.73890256
89DYRK20.72499082
90ITK0.72076213
91CDK60.71378390
92CDK20.71199632
93BLK0.69410548
94BTK0.68059901
95PRKAA20.67842944
96PRKCE0.66678575
97FLT30.66378703
98MUSK0.65647502
99CDK10.63455774
100MAPK110.62976090
101PIM20.62113751
102MAP3K140.61927760
103SIK10.60797347
104LYN0.60348491
105JAK30.59190386
106NLK0.59013788
107STK30.58820011
108CAMKK20.58604052
109CSNK2A10.57980043
110CDK190.57868543
111PRKCG0.57700754
112SYK0.57177680
113MST40.56398126
114NTRK30.54767675
115RPS6KA50.54374483
116MATK0.54308584
117PIK3CA0.54088730
118PAK30.53424005
119PRKCQ0.53077136
120IKBKB0.52474773
121AKT20.51526471
122CSNK1D0.51023010
123CHUK0.50630652
124STK110.50155666
125MARK10.49045465
126BRAF0.47386425
127TNIK0.47313102
128PLK20.46776625
129LATS10.45771351
130PRKAA10.43192716
131MAPKAPK50.42985417
132TIE10.42542376
133CSNK2A20.42469634
134MAPK130.41873693
135MAP2K60.41120740
136CDK30.41013345
137SGK20.40099452
138TRPM70.39804764
139WNK10.39505480
140ADRBK20.39133935
141AKT10.38958029
142CSNK1A10.38823226
143PNCK0.38702447
144PKN10.38571963
145PBK0.37245727
146RPS6KA60.36716207
147PRKDC0.35160337
148NUAK10.34682413
149MAPKAPK20.34328495
150NEK90.33803157
151CSF1R0.32888293
152MAPK140.30811779
153MAP2K30.29683113
154TYK20.28268298
155KDR0.27318674
156TESK20.26591731
157TGFBR10.24734555
158IKBKE0.24637042

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.42442049
2Mismatch repair_Homo sapiens_hsa034304.38892600
3Homologous recombination_Homo sapiens_hsa034403.78757274
4Base excision repair_Homo sapiens_hsa034103.46624102
5Fanconi anemia pathway_Homo sapiens_hsa034603.29665929
6Nitrogen metabolism_Homo sapiens_hsa009102.91239280
7Cell cycle_Homo sapiens_hsa041102.89786337
8Spliceosome_Homo sapiens_hsa030402.83637436
9Nucleotide excision repair_Homo sapiens_hsa034202.82697595
10Phototransduction_Homo sapiens_hsa047442.73168058
11Butanoate metabolism_Homo sapiens_hsa006502.70878096
12Ribosome_Homo sapiens_hsa030102.55742250
13Nicotine addiction_Homo sapiens_hsa050332.52229762
14Non-homologous end-joining_Homo sapiens_hsa034502.43389879
15One carbon pool by folate_Homo sapiens_hsa006702.32743209
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.32715265
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25152984
18Pyrimidine metabolism_Homo sapiens_hsa002402.23916776
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23803335
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18339021
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16420207
22Linoleic acid metabolism_Homo sapiens_hsa005912.14576198
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14174907
24RNA polymerase_Homo sapiens_hsa030202.06872464
25RNA transport_Homo sapiens_hsa030132.04729177
26ABC transporters_Homo sapiens_hsa020102.01579629
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96402002
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93472932
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90336870
30Tryptophan metabolism_Homo sapiens_hsa003801.85532713
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.83557981
32Selenocompound metabolism_Homo sapiens_hsa004501.79336517
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.76092524
34Systemic lupus erythematosus_Homo sapiens_hsa053221.72850256
35p53 signaling pathway_Homo sapiens_hsa041151.67890042
36Ether lipid metabolism_Homo sapiens_hsa005651.66686127
37Taste transduction_Homo sapiens_hsa047421.64635243
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58009393
39RNA degradation_Homo sapiens_hsa030181.57337394
40Basal transcription factors_Homo sapiens_hsa030221.54702913
41Olfactory transduction_Homo sapiens_hsa047401.49980619
42Proteasome_Homo sapiens_hsa030501.48918308
43Primary immunodeficiency_Homo sapiens_hsa053401.43231879
44Morphine addiction_Homo sapiens_hsa050321.42650085
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.42626266
46Propanoate metabolism_Homo sapiens_hsa006401.41512684
47Herpes simplex infection_Homo sapiens_hsa051681.31854584
48Caffeine metabolism_Homo sapiens_hsa002321.28224909
49mRNA surveillance pathway_Homo sapiens_hsa030151.23529414
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22726151
51Hematopoietic cell lineage_Homo sapiens_hsa046401.17199426
52Purine metabolism_Homo sapiens_hsa002301.16081257
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.15020024
54Glycerolipid metabolism_Homo sapiens_hsa005611.14260844
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12503760
56Regulation of autophagy_Homo sapiens_hsa041401.11358597
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07477464
58Measles_Homo sapiens_hsa051621.06831210
59Serotonergic synapse_Homo sapiens_hsa047261.03995846
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.01901885
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00972380
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00913441
63Epstein-Barr virus infection_Homo sapiens_hsa051690.99382108
64GABAergic synapse_Homo sapiens_hsa047270.99174011
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99015837
66HTLV-I infection_Homo sapiens_hsa051660.92281852
67Viral carcinogenesis_Homo sapiens_hsa052030.89473308
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.86013551
69Peroxisome_Homo sapiens_hsa041460.84809812
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82975654
71Ovarian steroidogenesis_Homo sapiens_hsa049130.82564539
72Small cell lung cancer_Homo sapiens_hsa052220.80491626
73Chemical carcinogenesis_Homo sapiens_hsa052040.80480814
74Calcium signaling pathway_Homo sapiens_hsa040200.79775475
75Salivary secretion_Homo sapiens_hsa049700.78574109
76Arachidonic acid metabolism_Homo sapiens_hsa005900.78223133
77Dorso-ventral axis formation_Homo sapiens_hsa043200.77600655
78Hepatitis B_Homo sapiens_hsa051610.76848789
79Circadian entrainment_Homo sapiens_hsa047130.75612323
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74294763
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74148098
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.73538908
83Alcoholism_Homo sapiens_hsa050340.72670611
84Apoptosis_Homo sapiens_hsa042100.72560495
85Glutamatergic synapse_Homo sapiens_hsa047240.71743017
86Influenza A_Homo sapiens_hsa051640.67814568
87Asthma_Homo sapiens_hsa053100.67768844
88Retinol metabolism_Homo sapiens_hsa008300.65471079
89Leishmaniasis_Homo sapiens_hsa051400.65315250
90Antigen processing and presentation_Homo sapiens_hsa046120.64314849
91MicroRNAs in cancer_Homo sapiens_hsa052060.63839929
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62688606
93Circadian rhythm_Homo sapiens_hsa047100.61542843
94N-Glycan biosynthesis_Homo sapiens_hsa005100.61229477
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60051292
96Protein export_Homo sapiens_hsa030600.59421845
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58223331
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57652689
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56511195
100Chronic myeloid leukemia_Homo sapiens_hsa052200.54095758
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53934595
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53401737
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52864550
104Metabolic pathways_Homo sapiens_hsa011000.51757095
105Legionellosis_Homo sapiens_hsa051340.51233556
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51080062
107Sphingolipid metabolism_Homo sapiens_hsa006000.50636008
108Oocyte meiosis_Homo sapiens_hsa041140.50471362
109Insulin secretion_Homo sapiens_hsa049110.50340936
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.49643489
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49265626
112Allograft rejection_Homo sapiens_hsa053300.48496540
113Fatty acid metabolism_Homo sapiens_hsa012120.47750866
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.47003377
115Collecting duct acid secretion_Homo sapiens_hsa049660.46001143
116B cell receptor signaling pathway_Homo sapiens_hsa046620.45700823
117Sulfur relay system_Homo sapiens_hsa041220.45603254
118Folate biosynthesis_Homo sapiens_hsa007900.45531473
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45152397
120beta-Alanine metabolism_Homo sapiens_hsa004100.44951505
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44893514
122Histidine metabolism_Homo sapiens_hsa003400.44879548
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43338712
124Lysine degradation_Homo sapiens_hsa003100.43217135
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42854025
126Notch signaling pathway_Homo sapiens_hsa043300.41594280
127Renin-angiotensin system_Homo sapiens_hsa046140.41441625
128Fatty acid biosynthesis_Homo sapiens_hsa000610.40730143
129African trypanosomiasis_Homo sapiens_hsa051430.40215677
130Other glycan degradation_Homo sapiens_hsa005110.38652275
131Fatty acid degradation_Homo sapiens_hsa000710.37481395
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37465858
133Acute myeloid leukemia_Homo sapiens_hsa052210.36607147
134Melanoma_Homo sapiens_hsa052180.34924867
135Oxidative phosphorylation_Homo sapiens_hsa001900.34246035
136Colorectal cancer_Homo sapiens_hsa052100.33745396
137Autoimmune thyroid disease_Homo sapiens_hsa053200.32248649
138Malaria_Homo sapiens_hsa051440.31858385
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30632131
140Dopaminergic synapse_Homo sapiens_hsa047280.30253783
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29461562
142Pancreatic cancer_Homo sapiens_hsa052120.28812844
143Non-small cell lung cancer_Homo sapiens_hsa052230.27867511
144Shigellosis_Homo sapiens_hsa051310.26519996
145Prostate cancer_Homo sapiens_hsa052150.26505032
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.26440583
147Osteoclast differentiation_Homo sapiens_hsa043800.25923386
148Tuberculosis_Homo sapiens_hsa051520.25040073
149Pentose phosphate pathway_Homo sapiens_hsa000300.24313186
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24097268
151Pathways in cancer_Homo sapiens_hsa052000.23328437
152Toxoplasmosis_Homo sapiens_hsa051450.21930942
153T cell receptor signaling pathway_Homo sapiens_hsa046600.21615057
154TNF signaling pathway_Homo sapiens_hsa046680.20332201
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18747646
156Bladder cancer_Homo sapiens_hsa052190.18346845
157Graft-versus-host disease_Homo sapiens_hsa053320.17936443
158Huntingtons disease_Homo sapiens_hsa050160.17663849
159Viral myocarditis_Homo sapiens_hsa054160.17181639
160FoxO signaling pathway_Homo sapiens_hsa040680.16640123
161Pertussis_Homo sapiens_hsa051330.16630762
162Type I diabetes mellitus_Homo sapiens_hsa049400.16252252
163Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15131875

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