ANKLE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.83974399
2nuclear pore organization (GO:0006999)4.58933291
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.31011972
4regulation of vitamin D biosynthetic process (GO:0060556)4.23418701
5pore complex assembly (GO:0046931)4.03501219
6cellular response to exogenous dsRNA (GO:0071360)4.03147104
7hemidesmosome assembly (GO:0031581)3.96294234
8mitotic sister chromatid cohesion (GO:0007064)3.83234427
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.80891155
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80891155
11mannose metabolic process (GO:0006013)3.71370547
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69626117
13regulation of interleukin-12 biosynthetic process (GO:0045075)3.57519771
14antigen processing and presentation of endogenous antigen (GO:0019883)3.54345856
15CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.53270361
16regulation of histone H3-K9 methylation (GO:0051570)3.50129962
17monoubiquitinated protein deubiquitination (GO:0035520)3.43324666
18regulation of hippo signaling (GO:0035330)3.36620263
19histone mRNA catabolic process (GO:0071044)3.30726704
20positive regulation of gamma-delta T cell activation (GO:0046645)3.27962365
21mitotic chromosome condensation (GO:0007076)3.27104569
22cellular response to ATP (GO:0071318)3.26631753
23IMP biosynthetic process (GO:0006188)3.23562768
24regulation of helicase activity (GO:0051095)3.23048882
25positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20366151
26positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20366151
27positive regulation of mitotic sister chromatid separation (GO:1901970)3.20366151
28negative regulation of histone methylation (GO:0031061)3.20156720
29positive regulation of CREB transcription factor activity (GO:0032793)3.17773129
30DNA unwinding involved in DNA replication (GO:0006268)3.17371063
31positive regulation of defense response to virus by host (GO:0002230)3.17136402
32protein localization to kinetochore (GO:0034501)3.12764012
33regulation of DNA endoreduplication (GO:0032875)3.11086037
34snRNA transcription (GO:0009301)3.09998627
35mitotic nuclear envelope disassembly (GO:0007077)3.08656655
36snRNA processing (GO:0016180)3.08292505
37pericardium development (GO:0060039)3.07621118
38positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.07592820
39regulation of integrin activation (GO:0033623)3.06791789
40protein K48-linked deubiquitination (GO:0071108)3.06757386
41regulation of T-helper 1 cell differentiation (GO:0045625)3.05592632
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05491140
43regulation of vitamin metabolic process (GO:0030656)3.00939695
44T cell lineage commitment (GO:0002360)2.99355159
45attachment of spindle microtubules to kinetochore (GO:0008608)2.98532283
46cellular response to ethanol (GO:0071361)2.98457766
47positive regulation of chromosome segregation (GO:0051984)2.98027635
48somatic hypermutation of immunoglobulin genes (GO:0016446)2.97408549
49somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97408549
50positive regulation of histone deacetylation (GO:0031065)2.96952416
51dosage compensation (GO:0007549)2.96387718
52interleukin-1-mediated signaling pathway (GO:0070498)2.95774344
53DNA geometric change (GO:0032392)2.93504455
54DNA duplex unwinding (GO:0032508)2.93384180
55regulation of MHC class I biosynthetic process (GO:0045343)2.93312923
56response to muramyl dipeptide (GO:0032495)2.93243834
57protein localization to chromosome, centromeric region (GO:0071459)2.91201765
58negative regulation of DNA repair (GO:0045738)2.90966604
59chromatin assembly (GO:0031497)2.90891712
60snRNA metabolic process (GO:0016073)2.90702121
61histone H3-K4 trimethylation (GO:0080182)2.90432542
62regulation of histone phosphorylation (GO:0033127)2.89335612
63NIK/NF-kappaB signaling (GO:0038061)2.88001874
64kinetochore organization (GO:0051383)2.86550477
65glucocorticoid receptor signaling pathway (GO:0042921)2.85119601
66DNA synthesis involved in DNA repair (GO:0000731)2.82901386
67membrane disassembly (GO:0030397)2.82413762
68nuclear envelope disassembly (GO:0051081)2.82413762
69DNA replication-independent nucleosome assembly (GO:0006336)2.81731913
70DNA replication-independent nucleosome organization (GO:0034724)2.81731913
71chromatin remodeling at centromere (GO:0031055)2.81629385
72meiotic chromosome segregation (GO:0045132)2.81209333
73DNA replication-dependent nucleosome assembly (GO:0006335)2.81052079
74DNA replication-dependent nucleosome organization (GO:0034723)2.81052079
75negative regulation of granulocyte differentiation (GO:0030853)2.80791310
76DNA replication initiation (GO:0006270)2.80377118
77histone-serine phosphorylation (GO:0035404)2.77994647
78negative regulation of interleukin-12 production (GO:0032695)2.77491415
79CENP-A containing nucleosome assembly (GO:0034080)2.76944129
80histone H3-K36 demethylation (GO:0070544)2.76822773
81necroptotic process (GO:0070266)2.75662822
82IMP metabolic process (GO:0046040)2.74957284
83regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74563189
84chromatin assembly or disassembly (GO:0006333)2.73730906
85positive regulation of protein import into nucleus, translocation (GO:0033160)2.72148815
86positive regulation of protein kinase C signaling (GO:0090037)2.71986343
87negative regulation of phagocytosis (GO:0050765)2.71623020
88DNA strand elongation involved in DNA replication (GO:0006271)2.71095224
89positive regulation of interferon-alpha production (GO:0032727)2.70075450
90DNA replication checkpoint (GO:0000076)2.69603314
91positive regulation of B cell differentiation (GO:0045579)2.68857694
92positive regulation of heat generation (GO:0031652)2.68100563
93folic acid-containing compound biosynthetic process (GO:0009396)2.67241425
94regulation of spindle organization (GO:0090224)2.66884363
95negative regulation of DNA-dependent DNA replication (GO:2000104)2.65048247
96regulation of defense response to virus by host (GO:0050691)2.64531655
97mitotic recombination (GO:0006312)2.64462173
98pre-miRNA processing (GO:0031054)2.63423978
99telomere maintenance via recombination (GO:0000722)2.63146007
100translesion synthesis (GO:0019985)2.62580300
101mitotic metaphase plate congression (GO:0007080)2.62168861
102response to protozoan (GO:0001562)2.61547582
103endosome to melanosome transport (GO:0035646)2.61476605
104endosome to pigment granule transport (GO:0043485)2.61476605
105sister chromatid cohesion (GO:0007062)2.60252719
106DNA strand elongation (GO:0022616)2.59749716
107negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58305439
108hepatocyte apoptotic process (GO:0097284)2.57947607
109positive regulation of protein deacetylation (GO:0090312)2.57598269
110interkinetic nuclear migration (GO:0022027)2.56213091
111B cell mediated immunity (GO:0019724)2.55265004
112telomere maintenance via semi-conservative replication (GO:0032201)2.54500229
113maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53838357
114regulation of interferon-alpha production (GO:0032647)2.53486259
115regulation of necroptotic process (GO:0060544)2.52779232
116regulation of chronic inflammatory response (GO:0002676)2.52689424
117response to peptidoglycan (GO:0032494)2.51840795
118DNA conformation change (GO:0071103)2.51561878
119regulation of interferon-beta production (GO:0032648)2.50983457
120cytoplasmic mRNA processing body assembly (GO:0033962)2.50769285
121gene silencing by RNA (GO:0031047)2.50337001
122sister chromatid segregation (GO:0000819)2.49970303
123regulation of gene silencing (GO:0060968)2.48875463
124intra-S DNA damage checkpoint (GO:0031573)2.48853431
125negative regulation of viral release from host cell (GO:1902187)2.48839243
126regulation of B cell differentiation (GO:0045577)2.48530075
127programmed necrotic cell death (GO:0097300)2.48525260
128mismatch repair (GO:0006298)2.48344359
129establishment of chromosome localization (GO:0051303)2.47544197
130negative regulation of B cell proliferation (GO:0030889)2.47540977
131regulation of apoptotic process involved in morphogenesis (GO:1902337)2.47097428
132germinal center formation (GO:0002467)2.46939352
133cellular response to zinc ion (GO:0071294)2.46705587
134peptidyl-lysine methylation (GO:0018022)2.46375191
135regulation of gene silencing by RNA (GO:0060966)2.45532090
136regulation of posttranscriptional gene silencing (GO:0060147)2.45532090
137regulation of gene silencing by miRNA (GO:0060964)2.45532090
138positive regulation of natural killer cell activation (GO:0032816)2.44772970
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.44492944
140postreplication repair (GO:0006301)2.43472363
141replication fork processing (GO:0031297)2.42765097
142purine nucleobase biosynthetic process (GO:0009113)2.42456008
143metaphase plate congression (GO:0051310)2.42185715
144regulation of mitotic spindle organization (GO:0060236)2.42013333
145regulation of RNA export from nucleus (GO:0046831)2.41997646
146regulation of interferon-beta biosynthetic process (GO:0045357)2.41940842
147nucleobase biosynthetic process (GO:0046112)2.41285431
148cell-substrate junction assembly (GO:0007044)2.39984542
149regulation of interferon-gamma biosynthetic process (GO:0045072)2.37890555
150negative regulation of fatty acid transport (GO:2000192)2.37698177
151cellular response to virus (GO:0098586)2.37685028
152heterochromatin organization (GO:0070828)2.37476818
153telomere maintenance (GO:0000723)2.36607302
154negative regulation of macroautophagy (GO:0016242)2.36379555
155positive regulation of keratinocyte differentiation (GO:0045618)2.36109906
156protein localization to chromosome (GO:0034502)2.35736442
157kinetochore assembly (GO:0051382)2.35605064
158embryonic process involved in female pregnancy (GO:0060136)2.35582306
159response to exogenous dsRNA (GO:0043330)2.35469960
160positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.35189022
161regulation of gamma-delta T cell activation (GO:0046643)2.35000622
162regulation of NFAT protein import into nucleus (GO:0051532)2.34976548
163corticosteroid receptor signaling pathway (GO:0031958)2.34859916
164mature B cell differentiation involved in immune response (GO:0002313)2.34172118
165cellular response to dsRNA (GO:0071359)2.33885115
166positive regulation of histone methylation (GO:0031062)2.33735489
167necrotic cell death (GO:0070265)2.33435297
168positive regulation of developmental pigmentation (GO:0048087)2.32546003
169regulation of dendritic cell antigen processing and presentation (GO:0002604)2.31675727
170mature B cell differentiation (GO:0002335)2.31592829
171kynurenine metabolic process (GO:0070189)2.31329961
172defense response to protozoan (GO:0042832)2.30299305
173positive regulation of interferon-beta production (GO:0032728)2.30259170
174tolerance induction (GO:0002507)2.29790108
175regulation of fatty acid beta-oxidation (GO:0031998)2.28440894
176regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.27430769
177negative regulation of tumor necrosis factor production (GO:0032720)2.26280643
178positive regulation of transcription factor import into nucleus (GO:0042993)2.25866364
179macrophage activation involved in immune response (GO:0002281)2.24765994
180positive regulation of fatty acid beta-oxidation (GO:0032000)2.24493970
181response to type I interferon (GO:0034340)2.24030612
182histone phosphorylation (GO:0016572)2.22325209
183striated muscle atrophy (GO:0014891)2.22003025
184negative regulation of macrophage differentiation (GO:0045650)2.21084010
185positive regulation of chemokine biosynthetic process (GO:0045080)2.21010416
186negative regulation of interleukin-6 production (GO:0032715)2.20242937
187regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.19714408
188histone lysine methylation (GO:0034968)2.19020513
189negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.18816835
190histone H3-K9 methylation (GO:0051567)2.15934032
191negative regulation by host of viral transcription (GO:0043922)2.15141463
192low-density lipoprotein particle clearance (GO:0034383)2.15080551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.68943829
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.74378477
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.71189585
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59969648
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.30315712
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06437979
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64124153
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60770846
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54156937
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.53283306
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50521698
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.35967951
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34349220
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31939330
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26474843
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24859008
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.23844058
18ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.19175050
19MYC_22102868_ChIP-Seq_BL_Human2.16568959
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.14722891
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07860158
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04501481
23E2F7_22180533_ChIP-Seq_HELA_Human10.4535399
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.99586833
25KDM2B_26808549_Chip-Seq_DND41_Human1.94890134
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.94076788
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92320753
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92087832
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.88437133
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86932484
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85174663
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83722063
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82519205
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.81218283
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79559422
36MAF_26560356_Chip-Seq_TH2_Human1.77459567
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77149672
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77083510
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77083510
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75384933
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73294901
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73080418
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71487887
44TP53_22127205_ChIP-Seq_IMR90_Human1.70378115
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.65138081
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64611835
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.61690494
48UBF1/2_26484160_Chip-Seq_HMECs_Human1.61386989
49GATA1_22025678_ChIP-Seq_K562_Human1.59015379
50AR_21909140_ChIP-Seq_LNCAP_Human1.58694019
51ELK1_19687146_ChIP-ChIP_HELA_Human1.57226619
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.56173830
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56058900
54MYB_26560356_Chip-Seq_TH2_Human1.55846743
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54294542
56MYB_26560356_Chip-Seq_TH1_Human1.54189478
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52284829
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51889314
59SCL_19346495_ChIP-Seq_HPC-7_Human1.51749016
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51250764
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51046017
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.50609946
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50236882
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48793819
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.46704208
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46350425
67RACK7_27058665_Chip-Seq_MCF-7_Human1.45095812
68* SPI1_23547873_ChIP-Seq_NB4_Human1.43947253
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43904946
70LXR_22292898_ChIP-Seq_THP-1_Human1.43685445
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41883394
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41503086
73VDR_23849224_ChIP-Seq_CD4+_Human1.40641461
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.40576227
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40490839
76* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39298429
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38159240
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37677945
79CIITA_25753668_ChIP-Seq_RAJI_Human1.37154818
80* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36217463
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35733779
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35488639
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35452103
84KDM2B_26808549_Chip-Seq_K562_Human1.34530168
85* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34448421
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.33676208
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32065323
88TP53_16413492_ChIP-PET_HCT116_Human1.31631961
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30938198
90FOXP3_21729870_ChIP-Seq_TREG_Human1.30285887
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29711195
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29379572
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29311981
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28556694
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27375744
96TFEB_21752829_ChIP-Seq_HELA_Human1.26848133
97GATA1_19941826_ChIP-Seq_K562_Human1.25637124
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24982718
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23787784
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23656198
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23493451
102RUNX_20019798_ChIP-Seq_JUKART_Human1.23156039
103VDR_24787735_ChIP-Seq_THP-1_Human1.22443980
104VDR_21846776_ChIP-Seq_THP-1_Human1.19030296
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18851850
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18202406
107ATF3_27146783_Chip-Seq_COLON_Human1.17564838
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17508176
109P68_20966046_ChIP-Seq_HELA_Human1.17076089
110* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15371550
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14052275
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13606405
113P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12845191
114* KDM5A_27292631_Chip-Seq_BREAST_Human1.08594435
115* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08485810
116KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08237027
117TP53_23651856_ChIP-Seq_MEFs_Mouse1.07791444
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07221539
119* MAF_26560356_Chip-Seq_TH1_Human1.06971313
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06953067
121SMC4_20622854_ChIP-Seq_HELA_Human1.06923918
122BCOR_27268052_Chip-Seq_Bcells_Human1.06824931
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05817769
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05184171
125TCF7_22412390_ChIP-Seq_EML_Mouse1.03663915
126* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03116698
127PU_27001747_Chip-Seq_BMDM_Mouse1.02877931
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.02158311
129PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01845359
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01148820
131RUNX1_22412390_ChIP-Seq_EML_Mouse1.00866600
132* TP63_22573176_ChIP-Seq_HFKS_Human1.00747994
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.99868544
134CREB1_26743006_Chip-Seq_LNCaP_Human0.99617294
135VDR_24763502_ChIP-Seq_THP-1_Human0.98469670
136* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98135375
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.97907162
138AHR_22903824_ChIP-Seq_MCF-7_Human0.96468134
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95438553
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95322648
141UTX_26944678_Chip-Seq_JUKART_Human0.95245327
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94935424
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94428904
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94372714
145ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92889187
146GATA3_27048872_Chip-Seq_THYMUS_Human0.92559734
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90092759
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89156208
149* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88873877
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.87168972
151MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86103765
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85447307
153NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85303782
154* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82142909
155DCP1A_22483619_ChIP-Seq_HELA_Human0.78941059
156GABP_19822575_ChIP-Seq_HepG2_Human0.78714243
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78400142
158XRN2_22483619_ChIP-Seq_HELA_Human0.77940394
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77848807
160TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77737134
161E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77374658
162DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76997821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.24214682
2MP0008057_abnormal_DNA_replication3.14876924
3MP0001835_abnormal_antigen_presentation2.96066883
4MP0003303_peritoneal_inflammation2.74586377
5MP0010352_gastrointestinal_tract_polyps2.70060375
6MP0003111_abnormal_nucleus_morphology2.55464588
7MP0003077_abnormal_cell_cycle2.53828079
8MP0010307_abnormal_tumor_latency2.50337205
9MP0002396_abnormal_hematopoietic_system2.49517123
10MP0008007_abnormal_cellular_replicative2.33993051
11MP0003453_abnormal_keratinocyte_physiol2.27098163
12MP0008058_abnormal_DNA_repair2.18720729
13MP0003693_abnormal_embryo_hatching2.17585400
14MP0004808_abnormal_hematopoietic_stem2.09363947
15MP0009840_abnormal_foam_cell2.08261260
16MP0003091_abnormal_cell_migration2.01638345
17MP0002166_altered_tumor_susceptibility1.98318253
18MP0008961_abnormal_basal_metabolism1.96688928
19MP0000569_abnormal_digit_pigmentation1.93825806
20MP0000383_abnormal_hair_follicle1.89725462
21MP0001800_abnormal_humoral_immune1.84621063
22MP0003300_gastrointestinal_ulcer1.82740644
23MP0003763_abnormal_thymus_physiology1.80385445
24MP0002006_tumorigenesis1.79490372
25MP0004957_abnormal_blastocyst_morpholog1.76756829
26MP0002452_abnormal_antigen_presenting1.73565305
27MP0004185_abnormal_adipocyte_glucose1.73432953
28MP0002009_preneoplasia1.71182239
29MP0002398_abnormal_bone_marrow1.68056312
30MP0002332_abnormal_exercise_endurance1.66477141
31MP0001790_abnormal_immune_system1.62645921
32MP0005387_immune_system_phenotype1.62645921
33MP0001348_abnormal_lacrimal_gland1.58568353
34MP0008877_abnormal_DNA_methylation1.56319910
35MP0000685_abnormal_immune_system1.54057485
36MP0002420_abnormal_adaptive_immunity1.51620316
37MP0001819_abnormal_immune_cell1.50820998
38MP0005076_abnormal_cell_differentiation1.50308809
39MP0005023_abnormal_wound_healing1.49195212
40MP0002877_abnormal_melanocyte_morpholog1.48821293
41MP0003950_abnormal_plasma_membrane1.46697979
42MP0004130_abnormal_muscle_cell1.45552022
43MP0005671_abnormal_response_to1.44473585
44MP0000579_abnormal_nail_morphology1.44135064
45MP0002723_abnormal_immune_serum1.41716192
46MP0000689_abnormal_spleen_morphology1.41663537
47MP0000350_abnormal_cell_proliferation1.41197333
48MP0003045_fibrosis1.40161177
49MP0003123_paternal_imprinting1.39495385
50MP0002419_abnormal_innate_immunity1.39365513
51MP0001853_heart_inflammation1.37257114
52MP0000716_abnormal_immune_system1.36997547
53MP0005000_abnormal_immune_tolerance1.36761057
54MP0000490_abnormal_crypts_of1.34370422
55MP0009764_decreased_sensitivity_to1.33777911
56MP0003436_decreased_susceptibility_to1.32767210
57MP0001216_abnormal_epidermal_layer1.31577639
58MP0002722_abnormal_immune_system1.31336855
59MP0010678_abnormal_skin_adnexa1.26232543
60MP0000703_abnormal_thymus_morphology1.25220375
61MP0002405_respiratory_system_inflammati1.24817805
62MP0004510_myositis1.24361897
63MP0009785_altered_susceptibility_to1.23393970
64MP0002429_abnormal_blood_cell1.21958464
65MP0000427_abnormal_hair_cycle1.21705206
66MP0005397_hematopoietic_system_phenotyp1.19714016
67MP0001545_abnormal_hematopoietic_system1.19714016
68MP0005025_abnormal_response_to1.18526792
69MP0006054_spinal_hemorrhage1.17820762
70MP0002019_abnormal_tumor_incidence1.16432925
71MP0003646_muscle_fatigue1.15590680
72MP0001730_embryonic_growth_arrest1.12422577
73MP0002132_abnormal_respiratory_system1.12376739
74MP0002086_abnormal_extraembryonic_tissu1.11979572
75MP0003121_genomic_imprinting1.11432909
76MP0005409_darkened_coat_color1.11086683
77MP0000465_gastrointestinal_hemorrhage1.10934194
78MP0003566_abnormal_cell_adhesion1.10413135
79MP0004233_abnormal_muscle_weight1.10125514
80MP0001533_abnormal_skeleton_physiology1.09721414
81MP0005058_abnormal_lysosome_morphology1.09122151
82MP0005380_embryogenesis_phenotype1.08539152
83MP0001672_abnormal_embryogenesis/_devel1.08539152
84MP0002148_abnormal_hypersensitivity_rea1.08080627
85MP0003984_embryonic_growth_retardation1.07288201
86MP0005464_abnormal_platelet_physiology1.05697217
87MP0002088_abnormal_embryonic_growth/wei1.05684450
88MP0003943_abnormal_hepatobiliary_system1.05495520
89MP0002998_abnormal_bone_remodeling1.05080827
90MP0005367_renal/urinary_system_phenotyp1.04061135
91MP0000516_abnormal_urinary_system1.04061135
92MP0000313_abnormal_cell_death1.03733707
93MP0001293_anophthalmia1.01683260
94MP0002060_abnormal_skin_morphology1.01680437
95MP0001915_intracranial_hemorrhage1.01505491
96MP0002933_joint_inflammation1.01245864
97MP0010155_abnormal_intestine_physiology1.00166225
98MP0000371_diluted_coat_color0.98981163
99MP0004197_abnormal_fetal_growth/weight/0.98790448
100MP0000003_abnormal_adipose_tissue0.95719461
101MP0003786_premature_aging0.95671953
102MP0000858_altered_metastatic_potential0.95548844
103MP0005451_abnormal_body_composition0.95237580
104MP0004381_abnormal_hair_follicle0.95114725
105MP0003787_abnormal_imprinting0.95087118
106MP0001873_stomach_inflammation0.93997900
107MP0002928_abnormal_bile_duct0.92694108
108MP0000470_abnormal_stomach_morphology0.91742877
109MP0001845_abnormal_inflammatory_respons0.90661160
110MP0003705_abnormal_hypodermis_morpholog0.90050728
111MP0003172_abnormal_lysosome_physiology0.90004309
112MP0000015_abnormal_ear_pigmentation0.89749620
113MP0001119_abnormal_female_reproductive0.89414348
114MP0005621_abnormal_cell_physiology0.89355615
115MP0004947_skin_inflammation0.88528630
116MP0001191_abnormal_skin_condition0.87747145
117MP0001849_ear_inflammation0.86260979
118MP0009053_abnormal_anal_canal0.85110216
119MP0001663_abnormal_digestive_system0.84376056
120MP0004043_abnormal_pH_regulation0.84349665
121MP0009278_abnormal_bone_marrow0.84127447
122MP0005375_adipose_tissue_phenotype0.83897990
123MP0001697_abnormal_embryo_size0.83748380
124MP0003279_aneurysm0.83229236
125MP0009384_cardiac_valve_regurgitation0.82735877
126MP0003567_abnormal_fetal_cardiomyocyte0.82416215
127MP0000538_abnormal_urinary_bladder0.79691302
128MP0001243_abnormal_dermal_layer0.79076237
129MP0005266_abnormal_metabolism0.79033449
130MP0005174_abnormal_tail_pigmentation0.78516523
131MP0005390_skeleton_phenotype0.78144924
132MP0009931_abnormal_skin_appearance0.77271528
133MP0002080_prenatal_lethality0.77108830
134MP0009115_abnormal_fat_cell0.76014464
135MP0000733_abnormal_muscle_development0.75450652
136MP0005310_abnormal_salivary_gland0.74645770
137MP0002075_abnormal_coat/hair_pigmentati0.73873519
138MP0002084_abnormal_developmental_patter0.73332288
139MP0006082_CNS_inflammation0.73040110
140MP0002210_abnormal_sex_determination0.73004151
141MP0004264_abnormal_extraembryonic_tissu0.72597184
142MP0003448_altered_tumor_morphology0.72541116
143MP0002092_abnormal_eye_morphology0.72082774
144MP0002138_abnormal_hepatobiliary_system0.72003176
145MP0002085_abnormal_embryonic_tissue0.71362971
146MP0000767_abnormal_smooth_muscle0.71355645
147MP0009333_abnormal_splenocyte_physiolog0.70997164

Predicted human phenotypes

RankGene SetZ-score
1Syringomyelia (HP:0003396)4.09909899
2Spinal cord lesions (HP:0100561)4.09909899
3Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.85672015
4Increased neuronal autofluorescent lipopigment (HP:0002074)3.59709585
5Chromsome breakage (HP:0040012)3.50505960
6Abnormality of the fingertips (HP:0001211)3.32585881
7Increased cerebral lipofuscin (HP:0011813)3.30407211
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28415658
9Genetic anticipation (HP:0003743)3.08655331
10Milia (HP:0001056)3.06567156
11Dysmetric saccades (HP:0000641)2.94841455
12Breast hypoplasia (HP:0003187)2.94038772
13Hyperacusis (HP:0010780)2.92819051
14Recurrent viral infections (HP:0004429)2.89926065
15Thrombocytosis (HP:0001894)2.89010590
16Broad face (HP:0000283)2.85489308
17Agnosia (HP:0010524)2.83452836
18Absent frontal sinuses (HP:0002688)2.81377034
19Protruding tongue (HP:0010808)2.77037280
20Eczematoid dermatitis (HP:0000976)2.74958488
21Thin bony cortex (HP:0002753)2.70552046
2211 pairs of ribs (HP:0000878)2.68511963
23Recurrent bacterial skin infections (HP:0005406)2.68342774
24Abnormality of chromosome stability (HP:0003220)2.66370065
25Mediastinal lymphadenopathy (HP:0100721)2.65692267
26Recurrent abscess formation (HP:0002722)2.65666018
27Acute myeloid leukemia (HP:0004808)2.62804148
28Lip pit (HP:0100267)2.62001896
29Persistence of primary teeth (HP:0006335)2.59787746
30Clumsiness (HP:0002312)2.57555868
31IgM deficiency (HP:0002850)2.52810195
32Colon cancer (HP:0003003)2.50011934
33Squamous cell carcinoma (HP:0002860)2.49672432
34Ectopic kidney (HP:0000086)2.48712878
35Global brain atrophy (HP:0002283)2.47810059
36Recurrent bronchitis (HP:0002837)2.41898740
37Chronic otitis media (HP:0000389)2.38417649
38Myelodysplasia (HP:0002863)2.32310610
39Duplicated collecting system (HP:0000081)2.31186667
40Cellulitis (HP:0100658)2.30923337
41Amaurosis fugax (HP:0100576)2.30739707
42Recurrent fungal infections (HP:0002841)2.30072545
43Hematochezia (HP:0002573)2.29909140
44Abnormality of liposaccharide metabolism (HP:0010968)2.29781798
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.29781798
46Abnormality of glycolipid metabolism (HP:0010969)2.29781798
47Volvulus (HP:0002580)2.28718758
48Atrophic scars (HP:0001075)2.28127693
49Cutaneous melanoma (HP:0012056)2.28100593
50Myositis (HP:0100614)2.25301862
51Cheilitis (HP:0100825)2.23848781
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.23783010
53Abnormality of T cell number (HP:0011839)2.21969117
54Spondylolisthesis (HP:0003302)2.21890018
55Short 4th metacarpal (HP:0010044)2.20608840
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20608840
57Ulnar bowing (HP:0003031)2.18379764
58Birth length less than 3rd percentile (HP:0003561)2.16579437
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.16290676
60Medulloblastoma (HP:0002885)2.16238807
61Poikiloderma (HP:0001029)2.16138324
62T lymphocytopenia (HP:0005403)2.15602420
63Rhabdomyosarcoma (HP:0002859)2.15237087
64Periodontitis (HP:0000704)2.14581350
65IgA deficiency (HP:0002720)2.13918605
66Patellar aplasia (HP:0006443)2.12341868
67Selective tooth agenesis (HP:0001592)2.12248258
68Hypoplasia of the thymus (HP:0000778)2.11995376
69Clubbing of toes (HP:0100760)2.11376820
70Agammaglobulinemia (HP:0004432)2.10664270
71Biliary tract neoplasm (HP:0100574)2.10075875
72Osteomyelitis (HP:0002754)2.07072394
73Abnormal spermatogenesis (HP:0008669)2.05882705
74Long eyelashes (HP:0000527)2.05240136
75Abnormality of nail color (HP:0100643)2.02906224
76Osteolytic defects of the hand bones (HP:0009699)2.01356803
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.01356803
78Abnormality of the renal collecting system (HP:0004742)2.00105111
79Aplasia/Hypoplasia of the patella (HP:0006498)1.99899304
80Lymphoma (HP:0002665)1.98220030
81Short chin (HP:0000331)1.97963178
82Subacute progressive viral hepatitis (HP:0006572)1.96854114
83Sparse lateral eyebrow (HP:0005338)1.96403664
84Meningitis (HP:0001287)1.96382646
85Acute lymphatic leukemia (HP:0006721)1.95814809
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.95627796
87Abnormal biliary tract morphology (HP:0012440)1.95213144
88Increased number of teeth (HP:0011069)1.95052178
89Impaired smooth pursuit (HP:0007772)1.94210091
90Thyroiditis (HP:0100646)1.93697829
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.93476963
92Recurrent gram-negative bacterial infections (HP:0005420)1.93442278
93Bicuspid aortic valve (HP:0001647)1.93402204
94Rectal prolapse (HP:0002035)1.93239151
95Abnormality of cells of the lymphoid lineage (HP:0012140)1.92157628
96Prominent nose (HP:0000448)1.91394242
97Autoimmune thrombocytopenia (HP:0001973)1.91290489
98Hypochromic anemia (HP:0001931)1.90666627
99Thick nail (HP:0001805)1.90307806
100Arterial thrombosis (HP:0004420)1.89836182
101Long clavicles (HP:0000890)1.89593820
102Lymphopenia (HP:0001888)1.89514222
103Retrobulbar optic neuritis (HP:0100654)1.89235858
104Optic neuritis (HP:0100653)1.89235858
105Oligodontia (HP:0000677)1.89044889
106Impulsivity (HP:0100710)1.87711220
107Ectropion (HP:0000656)1.87459790
108Flat cornea (HP:0007720)1.87002561
109Basal cell carcinoma (HP:0002671)1.86865810
110Meckel diverticulum (HP:0002245)1.86797179
111Dislocated radial head (HP:0003083)1.86644411
112Abnormal platelet volume (HP:0011876)1.85937897
113Recurrent pneumonia (HP:0006532)1.84905741
114Deep philtrum (HP:0002002)1.84204466
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84078960
116Abnormality of T cells (HP:0002843)1.83310618
117Natal tooth (HP:0000695)1.82081486
118Abnormality of the radial head (HP:0003995)1.81958710
119Ureteral stenosis (HP:0000071)1.81254124
120Colitis (HP:0002583)1.80261205
121Tibial bowing (HP:0002982)1.80008591
122Keratoconjunctivitis sicca (HP:0001097)1.79714189
123Abnormality of DNA repair (HP:0003254)1.78613954
124Malnutrition (HP:0004395)1.78435698
125Broad metatarsal (HP:0001783)1.77355475
126Abnormality of the sella turcica (HP:0002679)1.76181917
127Partial agenesis of the corpus callosum (HP:0001338)1.74398573
128Renovascular hypertension (HP:0100817)1.74162518
129High pitched voice (HP:0001620)1.73656019
130Limb hypertonia (HP:0002509)1.72565934
131Narrow palate (HP:0000189)1.71145075
132Abnormality of the preputium (HP:0100587)1.70577358
133Eosinophilia (HP:0001880)1.69972241
134Flat occiput (HP:0005469)1.69816505
135Sandal gap (HP:0001852)1.69804138
136Abnormality of the nasal septum (HP:0000419)1.69748977
137Abnormality of the frontal sinuses (HP:0002687)1.68915138
138Pustule (HP:0200039)1.68446212
139Short middle phalanx of the 5th finger (HP:0004220)1.68074411
140Ureteral obstruction (HP:0006000)1.66973085
141Dysostosis multiplex (HP:0000943)1.66755273
142Viral hepatitis (HP:0006562)1.66417066
143Papillary thyroid carcinoma (HP:0002895)1.66354480
144Radial bowing (HP:0002986)1.66016979
145Abnormality of the ileum (HP:0001549)1.65320663
146Plantar hyperkeratosis (HP:0007556)1.65068891
147Sloping forehead (HP:0000340)1.64666110
148Elfin facies (HP:0004428)1.64333585
149Bronchitis (HP:0012387)1.63797360
150Abnormality of the columella (HP:0009929)1.63506909
151Abnormality of the prostate (HP:0008775)1.63499385
152Recurrent skin infections (HP:0001581)1.62502163
153Interstitial pulmonary disease (HP:0006530)1.62428374
154Bowed forearm bones (HP:0003956)1.61706134
155Bowing of the arm (HP:0006488)1.61706134
156Leukopenia (HP:0001882)1.61597699
157Abnormality of the calcaneus (HP:0008364)1.61523380
158Azoospermia (HP:0000027)1.61370019
159Smooth philtrum (HP:0000319)1.61307509
160Encephalitis (HP:0002383)1.60976380
161Missing ribs (HP:0000921)1.60799758
162Increased IgE level (HP:0003212)1.60723547
163Abnormality of the carotid arteries (HP:0005344)1.60213437
164Vasculitis (HP:0002633)1.59681189
165Breast carcinoma (HP:0003002)1.59549145
166Chronic obstructive pulmonary disease (HP:0006510)1.59230022
167Obstructive lung disease (HP:0006536)1.59230022
168Hypoplasia of dental enamel (HP:0006297)1.58768315
169Short thumb (HP:0009778)1.58149099
170Cerebellar dysplasia (HP:0007033)1.57144980
171Ureteral duplication (HP:0000073)1.56849176
172Aortic regurgitation (HP:0001659)1.56190825
173Tubular atrophy (HP:0000092)1.56146474
174Tracheomalacia (HP:0002779)1.55555672
175Neonatal hypoglycemia (HP:0001998)1.55458837
176Bronchomalacia (HP:0002780)1.55377650
177Abnormality of the labia majora (HP:0012881)1.54752181
178Entropion (HP:0000621)1.54185429
179Abnormality of glycosaminoglycan metabolism (HP:0004371)1.53041511
180Abnormality of mucopolysaccharide metabolism (HP:0011020)1.53041511
181Abnormality of polysaccharide metabolism (HP:0011012)1.53041511
182Tented upper lip vermilion (HP:0010804)1.52880075
183Hyperventilation (HP:0002883)1.52809688
184Aplasia cutis congenita (HP:0001057)1.52792481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.92534316
2CDC73.46233197
3CDK123.20777215
4NEK22.52542439
5ZAK2.50320374
6ICK2.37930268
7MAP3K142.27738617
8MAP3K102.12623194
9JAK32.09200435
10FRK2.07116520
11MAP4K11.97101016
12STK31.96357198
13EEF2K1.95085730
14ACVR1B1.90424571
15FGFR31.74438281
16SIK21.72082585
17CAMK1G1.70491938
18STK41.65874476
19ATR1.62215450
20PIM11.60783152
21SRPK11.58397296
22CDC42BPA1.57413964
23TYK21.56691354
24BLK1.50796261
25FLT31.49929634
26MAPK111.47550187
27TAOK31.47340995
28ERN11.43105859
29MTOR1.41684332
30MAP3K131.40924789
31STK101.39871838
32CSF1R1.34921008
33ADRBK21.34564383
34PIM21.34385681
35BRD41.34139854
36CLK11.32421844
37EIF2AK31.32249614
38CHUK1.29056102
39CDK41.27573510
40MST1R1.26888634
41AKT31.25784430
42WEE11.23860444
43TEC1.22810884
44RPS6KB21.22776316
45CDK61.21669726
46KIT1.20207011
47RPS6KA41.19621826
48IRAK41.14997565
49PDGFRB1.14319748
50PASK1.14035349
51TTK1.13646740
52PLK41.12775419
53NEK91.12379729
54CDK91.11591835
55IKBKB1.09399931
56PKN21.09249710
57JAK11.08706675
58LATS11.07931771
59BTK1.06680374
60PRPF4B1.06520586
61AURKB1.05422854
62IKBKE1.05160216
63SMG11.04481520
64ATM1.04367245
65MET1.04274070
66EIF2AK11.03999092
67BRSK21.02923846
68NUAK11.02481608
69SGK21.02338196
70STK241.01938344
71DDR21.01506342
72MELK1.01074786
73CDK71.00005019
74MAP3K70.99158438
75VRK10.96962981
76IRAK30.95749973
77CHEK20.95329522
78CHEK10.93918562
79PDGFRA0.92254049
80TYRO30.90490918
81MARK20.89322387
82DYRK30.88853720
83IRAK10.87643558
84SCYL20.86976658
85PLK10.86445803
86PLK30.85829150
87TBK10.85482943
88RIPK10.83756529
89WNK10.83398519
90SGK30.82948838
91BMPR1B0.82921203
92MKNK10.82751654
93MAP2K60.82090608
94TRPM70.81305948
95WNK40.81071387
96TLK10.80756122
97HIPK20.80262726
98MAP3K80.77730535
99TXK0.77360414
100PRKD20.77347566
101CAMK1D0.76979716
102RPS6KC10.75894644
103RPS6KL10.75894644
104EIF2AK20.75408225
105RPS6KB10.74778558
106NLK0.74063936
107NEK10.73306497
108MAPK150.71831268
109NEK60.71094008
110TGFBR10.70662975
111NME20.70234074
112EPHA20.68502237
113* CDK20.68253720
114TSSK60.68226091
115PDPK10.68016548
116SYK0.67761779
117ERBB30.67646172
118TAOK10.67616523
119LMTK20.63876773
120BMX0.63613842
121EPHA30.63578112
122MARK30.60974807
123RPS6KA20.60794957
124RPS6KA50.59855000
125MATK0.58338549
126CSK0.57188306
127HCK0.57179196
128LYN0.57120014
129LCK0.56490871
130TAOK20.56222685
131YES10.55133099
132PDK10.54138992
133STK38L0.53859511
134CAMKK20.53564294
135PAK20.52128490
136CAMKK10.51876214
137GRK70.51748722
138SIK10.51657000
139MAP3K30.50870968
140MAP2K20.50471068
141TTN0.49511061
142RPS6KA60.49457706
143CDK10.47101809
144ADRBK10.46544822
145MAP2K30.46458820
146ZAP700.46458329
147MAPKAPK30.46121869
148PRKAA20.45696108
149FGFR40.45600726
150ABL10.44540828
151MKNK20.44528051
152PTK60.40560656
153MAP3K110.39100951

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.06534181
2Mismatch repair_Homo sapiens_hsa034302.83968506
3One carbon pool by folate_Homo sapiens_hsa006702.64486562
4Non-homologous end-joining_Homo sapiens_hsa034502.62316420
5Base excision repair_Homo sapiens_hsa034102.30246354
6Cell cycle_Homo sapiens_hsa041102.28996312
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25917032
8Systemic lupus erythematosus_Homo sapiens_hsa053222.13181219
9Homologous recombination_Homo sapiens_hsa034402.12287955
10Fanconi anemia pathway_Homo sapiens_hsa034602.04396239
11Herpes simplex infection_Homo sapiens_hsa051681.86674124
12RNA transport_Homo sapiens_hsa030131.82508594
13Antigen processing and presentation_Homo sapiens_hsa046121.81229654
14Nucleotide excision repair_Homo sapiens_hsa034201.79967565
15Bladder cancer_Homo sapiens_hsa052191.79122290
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.78548842
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72557357
18Primary immunodeficiency_Homo sapiens_hsa053401.70708673
19Measles_Homo sapiens_hsa051621.61660866
20B cell receptor signaling pathway_Homo sapiens_hsa046621.57674180
21mRNA surveillance pathway_Homo sapiens_hsa030151.57311333
22Spliceosome_Homo sapiens_hsa030401.52696275
23p53 signaling pathway_Homo sapiens_hsa041151.49503998
24Other glycan degradation_Homo sapiens_hsa005111.49282505
25RNA degradation_Homo sapiens_hsa030181.45022548
26Selenocompound metabolism_Homo sapiens_hsa004501.43950387
27Leishmaniasis_Homo sapiens_hsa051401.43171040
28Legionellosis_Homo sapiens_hsa051341.38572195
29Basal transcription factors_Homo sapiens_hsa030221.38473900
30Viral carcinogenesis_Homo sapiens_hsa052031.38161001
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36008383
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.35371549
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35050519
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34566461
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33998330
36VEGF signaling pathway_Homo sapiens_hsa043701.28791310
37Influenza A_Homo sapiens_hsa051641.27770294
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23886320
39MicroRNAs in cancer_Homo sapiens_hsa052061.20024466
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17696733
41Hematopoietic cell lineage_Homo sapiens_hsa046401.17332334
42Osteoclast differentiation_Homo sapiens_hsa043801.12740247
43Dorso-ventral axis formation_Homo sapiens_hsa043201.12119796
44Asthma_Homo sapiens_hsa053101.11963764
45Hepatitis B_Homo sapiens_hsa051611.08743438
46Lysine degradation_Homo sapiens_hsa003101.08440491
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06779447
48Small cell lung cancer_Homo sapiens_hsa052221.05779713
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05674635
50HTLV-I infection_Homo sapiens_hsa051661.05222824
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03554199
52Prolactin signaling pathway_Homo sapiens_hsa049171.03247899
53African trypanosomiasis_Homo sapiens_hsa051431.03082499
54Pyrimidine metabolism_Homo sapiens_hsa002401.00434216
55Epstein-Barr virus infection_Homo sapiens_hsa051690.99354504
56Chronic myeloid leukemia_Homo sapiens_hsa052200.99053824
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98489566
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.98442352
59Lysosome_Homo sapiens_hsa041420.98109229
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96044209
61Autoimmune thyroid disease_Homo sapiens_hsa053200.95197376
62mTOR signaling pathway_Homo sapiens_hsa041500.95172066
63Toxoplasmosis_Homo sapiens_hsa051450.94892773
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.93812005
65Adherens junction_Homo sapiens_hsa045200.91823860
66Apoptosis_Homo sapiens_hsa042100.91351129
67RNA polymerase_Homo sapiens_hsa030200.89189285
68Sulfur relay system_Homo sapiens_hsa041220.89072082
69MAPK signaling pathway_Homo sapiens_hsa040100.85217835
70Viral myocarditis_Homo sapiens_hsa054160.80978098
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79582202
72TNF signaling pathway_Homo sapiens_hsa046680.79131263
73ErbB signaling pathway_Homo sapiens_hsa040120.78758203
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78459353
75Renal cell carcinoma_Homo sapiens_hsa052110.77475641
76Acute myeloid leukemia_Homo sapiens_hsa052210.74753592
77Allograft rejection_Homo sapiens_hsa053300.73446079
78Graft-versus-host disease_Homo sapiens_hsa053320.72689049
79Type II diabetes mellitus_Homo sapiens_hsa049300.70352346
80Pancreatic cancer_Homo sapiens_hsa052120.69706288
81TGF-beta signaling pathway_Homo sapiens_hsa043500.69661586
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69199803
83Malaria_Homo sapiens_hsa051440.68826655
84Staphylococcus aureus infection_Homo sapiens_hsa051500.68706879
85Tuberculosis_Homo sapiens_hsa051520.68310832
86FoxO signaling pathway_Homo sapiens_hsa040680.68299580
87Sphingolipid metabolism_Homo sapiens_hsa006000.68065365
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67605602
89Amoebiasis_Homo sapiens_hsa051460.66266537
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.66194238
91Notch signaling pathway_Homo sapiens_hsa043300.65838880
92Prostate cancer_Homo sapiens_hsa052150.64085923
93Rheumatoid arthritis_Homo sapiens_hsa053230.63616024
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63528518
95ECM-receptor interaction_Homo sapiens_hsa045120.63267915
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.63188669
97Shigellosis_Homo sapiens_hsa051310.62830663
98GnRH signaling pathway_Homo sapiens_hsa049120.60595450
99Focal adhesion_Homo sapiens_hsa045100.59937720
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59802964
101T cell receptor signaling pathway_Homo sapiens_hsa046600.58905991
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57711534
103Salmonella infection_Homo sapiens_hsa051320.57309905
104Melanoma_Homo sapiens_hsa052180.56908429
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.56896758
106Colorectal cancer_Homo sapiens_hsa052100.56847101
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55044829
108Choline metabolism in cancer_Homo sapiens_hsa052310.54847001
109N-Glycan biosynthesis_Homo sapiens_hsa005100.54832868
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54148606
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54028537
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53487901
113Ovarian steroidogenesis_Homo sapiens_hsa049130.52983807
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52964910
115Glioma_Homo sapiens_hsa052140.52466571
116Chemokine signaling pathway_Homo sapiens_hsa040620.51979404
117Alcoholism_Homo sapiens_hsa050340.51520953
118ABC transporters_Homo sapiens_hsa020100.50849753
119Non-small cell lung cancer_Homo sapiens_hsa052230.49137546
120Hepatitis C_Homo sapiens_hsa051600.48215304
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47546674
122Insulin resistance_Homo sapiens_hsa049310.46577569
123Inositol phosphate metabolism_Homo sapiens_hsa005620.46441832
124Type I diabetes mellitus_Homo sapiens_hsa049400.46076622
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45381580
126Platelet activation_Homo sapiens_hsa046110.44971525
127Purine metabolism_Homo sapiens_hsa002300.44687826
128Pertussis_Homo sapiens_hsa051330.43186005
129Proteoglycans in cancer_Homo sapiens_hsa052050.42708344
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40419242
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39570159
132Pathways in cancer_Homo sapiens_hsa052000.38743505
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.37583333
134Pentose phosphate pathway_Homo sapiens_hsa000300.37240170
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37044046
136Thyroid cancer_Homo sapiens_hsa052160.36409969
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.35801107
138Endometrial cancer_Homo sapiens_hsa052130.34403120

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »