ANKMY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.83753256
2epithelial cilium movement (GO:0003351)9.72534073
3reproduction (GO:0000003)9.57311210
4motile cilium assembly (GO:0044458)9.04217453
5spermatid development (GO:0007286)9.00946332
6male meiosis (GO:0007140)8.86966325
7regulation of cilium movement (GO:0003352)8.69326399
8cilium movement (GO:0003341)8.68609307
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.37758718
10synaptonemal complex organization (GO:0070193)7.85720569
11synaptonemal complex assembly (GO:0007130)7.61922886
12single fertilization (GO:0007338)7.56557666
13sperm capacitation (GO:0048240)7.53472581
14fertilization (GO:0009566)6.39940127
15DNA methylation involved in gamete generation (GO:0043046)6.08500408
16spermatogenesis (GO:0007283)5.92428787
17male gamete generation (GO:0048232)5.90061333
18negative regulation of inclusion body assembly (GO:0090084)5.89689593
19ventricular system development (GO:0021591)5.79941819
20male meiosis I (GO:0007141)5.67963491
21microtubule severing (GO:0051013)5.61536779
22gamete generation (GO:0007276)5.42745178
23chromosome organization involved in meiosis (GO:0070192)5.37724389
24organic cation transport (GO:0015695)5.35446556
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.33148653
26tolerance induction (GO:0002507)5.25559428
27germ cell development (GO:0007281)5.18545044
28cell recognition (GO:0008037)5.05185134
29microtubule depolymerization (GO:0007019)5.03578018
30meiotic nuclear division (GO:0007126)5.03117566
31regulation of microtubule-based movement (GO:0060632)5.01812078
32calcium ion-dependent exocytosis (GO:0017156)4.80324877
33regulation of inclusion body assembly (GO:0090083)4.74635902
34seminiferous tubule development (GO:0072520)4.62644379
35meiosis I (GO:0007127)4.54085822
36protein polyglutamylation (GO:0018095)4.53247669
37spermatid nucleus differentiation (GO:0007289)4.40772426
38regulation of germinal center formation (GO:0002634)4.33761959
39meiotic cell cycle (GO:0051321)4.30652016
40negative regulation of B cell mediated immunity (GO:0002713)4.29774265
41negative regulation of immunoglobulin mediated immune response (GO:0002890)4.29774265
42multicellular organismal reproductive process (GO:0048609)4.26013503
43left/right pattern formation (GO:0060972)4.19896060
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14414894
45monoubiquitinated protein deubiquitination (GO:0035520)4.12658858
46left/right axis specification (GO:0070986)4.07116418
47positive regulation of tolerance induction (GO:0002645)3.92684112
48protein localization to cilium (GO:0061512)3.92354117
49regulation of gamma-delta T cell differentiation (GO:0045586)3.83417042
50genitalia morphogenesis (GO:0035112)3.79361535
51gene silencing by RNA (GO:0031047)3.74608466
52regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.72814665
53chaperone-mediated protein complex assembly (GO:0051131)3.72068328
54phosphatidylethanolamine biosynthetic process (GO:0006646)3.65567048
55one-carbon compound transport (GO:0019755)3.62463786
56regulation of gamma-delta T cell activation (GO:0046643)3.60027355
57regulation of tolerance induction (GO:0002643)3.57831203
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56791266
59microtubule bundle formation (GO:0001578)3.56214311
60negative regulation of organelle assembly (GO:1902116)3.52571549
61intraciliary transport (GO:0042073)3.50146937
62negative regulation of humoral immune response (GO:0002921)3.48474390
63multicellular organismal development (GO:0007275)3.46475931
64antigen processing and presentation of endogenous antigen (GO:0019883)3.40660040
65primary alcohol catabolic process (GO:0034310)3.37266734
66positive regulation of gamma-delta T cell activation (GO:0046645)3.35844014
67microtubule-based movement (GO:0007018)3.33270525
68phosphatidylethanolamine metabolic process (GO:0046337)3.32754916
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31809515
70negative regulation of cell killing (GO:0031342)3.31809515
71synapsis (GO:0007129)3.31458525
72positive regulation of granulocyte differentiation (GO:0030854)3.29094292
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28248960
74regulation of interleukin-5 production (GO:0032674)3.26158549
75amino-acid betaine transport (GO:0015838)3.25886716
76carnitine transport (GO:0015879)3.25886716
77chromosome condensation (GO:0030261)3.25250800
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.24861296
79ethanol metabolic process (GO:0006067)3.23991069
80nuclear pore complex assembly (GO:0051292)3.23630925
81response to xenobiotic stimulus (GO:0009410)3.23494302
82regulation of centriole replication (GO:0046599)3.23347609
83carnitine transmembrane transport (GO:1902603)3.22435906
84meiotic cell cycle process (GO:1903046)3.21064473
85negative regulation of lymphocyte mediated immunity (GO:0002707)3.20913079
86vitamin transmembrane transport (GO:0035461)3.20610833
87glycerol ether metabolic process (GO:0006662)3.19508363
88regulation of spindle checkpoint (GO:0090231)3.16079436
89diterpenoid biosynthetic process (GO:0016102)3.15268632
90axoneme assembly (GO:0035082)3.14975050
91DNA packaging (GO:0006323)3.13579414
92cilium organization (GO:0044782)3.11678688
93regulation of interleukin-13 production (GO:0032656)3.04176239
94regulation of B cell receptor signaling pathway (GO:0050855)3.03177159
95negative thymic T cell selection (GO:0045060)3.01837028
96peptidyl-glutamic acid modification (GO:0018200)2.98688980
97negative T cell selection (GO:0043383)2.94401470
98protein K11-linked deubiquitination (GO:0035871)2.93799899
99cilium assembly (GO:0042384)2.93495170
100cellular response to exogenous dsRNA (GO:0071360)2.93063907
101ether metabolic process (GO:0018904)2.92814805
102cellular component assembly involved in morphogenesis (GO:0010927)2.91402297
103lactate metabolic process (GO:0006089)2.90924298
104negative regulation of T cell differentiation in thymus (GO:0033085)2.87567366
105negative regulation of adaptive immune response (GO:0002820)2.86057912
106nucleus organization (GO:0006997)2.85514713
107B cell receptor signaling pathway (GO:0050853)2.83710407
108protein refolding (GO:0042026)2.80832475
109positive thymic T cell selection (GO:0045059)2.79753158
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78121715
111negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.72551312
112gene silencing (GO:0016458)2.72367677
113cilium morphogenesis (GO:0060271)2.71744312
114microtubule polymerization or depolymerization (GO:0031109)2.71444785
115regulation of cilium assembly (GO:1902017)2.70828825
116mitotic sister chromatid cohesion (GO:0007064)2.70791160
117regulation of interleukin-6 biosynthetic process (GO:0045408)2.69169644
118lung epithelium development (GO:0060428)2.68542330
119single strand break repair (GO:0000012)2.67205219
120negative regulation of leukocyte mediated immunity (GO:0002704)2.66007559
121positive T cell selection (GO:0043368)2.64437660
122negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.64351497
123hydrogen peroxide biosynthetic process (GO:0050665)2.63797157
124mannose metabolic process (GO:0006013)2.63214958
125regulation of meiosis I (GO:0060631)2.63039112
126centriole replication (GO:0007099)2.62318697
127phosphatidylcholine biosynthetic process (GO:0006656)2.58990433
128cell projection assembly (GO:0030031)2.58659311
129centriole assembly (GO:0098534)2.57929567
130regulation of granulocyte differentiation (GO:0030852)2.56608863
131histone H3-K36 demethylation (GO:0070544)2.55444198
132nucleoside diphosphate phosphorylation (GO:0006165)2.54349863
133alditol metabolic process (GO:0019400)2.52998466
134glycolytic process (GO:0006096)2.52433694
135interferon-gamma secretion (GO:0072643)2.50202238
136regulation of response to osmotic stress (GO:0047484)2.48959958
137negative regulation of skeletal muscle tissue development (GO:0048642)2.48567526
138reactive oxygen species biosynthetic process (GO:1903409)2.47552518
139nuclear pore organization (GO:0006999)2.47112484
140thymic T cell selection (GO:0045061)2.46497953
141T cell selection (GO:0045058)2.46081562
142pore complex assembly (GO:0046931)2.45883300
143establishment of protein localization to Golgi (GO:0072600)2.43786514
144germinal center formation (GO:0002467)2.43333965
145glomerular epithelial cell development (GO:0072310)2.43129462
146regulation of acrosome reaction (GO:0060046)2.42567038
147activated T cell proliferation (GO:0050798)2.40970253
148hepatocyte apoptotic process (GO:0097284)2.40841827
149response to type I interferon (GO:0034340)2.38848133
150mucosal-associated lymphoid tissue development (GO:0048537)2.38800520
151Peyers patch development (GO:0048541)2.38800520
152calcium ion import (GO:0070509)2.38631153
153pyrimidine-containing compound transmembrane transport (GO:0072531)2.38354695
154cytoplasmic microtubule organization (GO:0031122)2.37476742
155detection of bacterium (GO:0016045)2.36934294
156regulation of Rab GTPase activity (GO:0032313)2.34217771
157positive regulation of Rab GTPase activity (GO:0032851)2.34217771
158ethanol oxidation (GO:0006069)2.32073361
159detection of other organism (GO:0098543)2.31282044
160positive regulation of protein deacetylation (GO:0090312)2.29202608
161regulation of interleukin-4 production (GO:0032673)2.26826254
162cilium or flagellum-dependent cell motility (GO:0001539)14.6770731
163fusion of sperm to egg plasma membrane (GO:0007342)13.1688893
164sperm motility (GO:0030317)12.4750815
165multicellular organism reproduction (GO:0032504)11.7102694
166acrosome assembly (GO:0001675)11.7021824
167sperm-egg recognition (GO:0035036)11.6763091
168axonemal dynein complex assembly (GO:0070286)10.7856416
169acrosome reaction (GO:0007340)10.6471707
170cell-cell recognition (GO:0009988)10.5261602
171binding of sperm to zona pellucida (GO:0007339)10.4310807
172cell wall macromolecule catabolic process (GO:0016998)10.2948464
173cell wall macromolecule metabolic process (GO:0044036)10.2948464
174plasma membrane fusion (GO:0045026)10.0285497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.32341748
2EZH2_22144423_ChIP-Seq_EOC_Human4.58248067
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.57176868
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38482296
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14426989
6* DROSHA_22980978_ChIP-Seq_HELA_Human2.82881453
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77078381
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66720818
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60726482
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.38449630
11SCL_19346495_ChIP-Seq_HPC-7_Human2.34102414
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.29015734
13RUNX_20019798_ChIP-Seq_JUKART_Human2.28470858
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.21341850
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20644374
16VDR_22108803_ChIP-Seq_LS180_Human2.18355601
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16999410
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12041658
19VDR_21846776_ChIP-Seq_THP-1_Human2.08625421
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03134970
21MAF_26560356_Chip-Seq_TH1_Human2.02667989
22ELK4_26923725_Chip-Seq_MESODERM_Mouse2.01938197
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2196894
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.99081215
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95585629
26VDR_24763502_ChIP-Seq_THP-1_Human1.95193871
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92790584
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86478615
29LXR_22292898_ChIP-Seq_THP-1_Human1.85017576
30SMC4_20622854_ChIP-Seq_HELA_Human1.82848367
31SPI1_23127762_ChIP-Seq_K562_Human1.81456926
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80135533
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80055287
34MYB_26560356_Chip-Seq_TH2_Human1.79558176
35GATA1_19941826_ChIP-Seq_K562_Human1.78012412
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77635565
37ZNF274_21170338_ChIP-Seq_K562_Hela1.77554617
38UTX_26944678_Chip-Seq_JUKART_Human1.77434744
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74809815
40P68_20966046_ChIP-Seq_HELA_Human1.74412218
41BCOR_27268052_Chip-Seq_Bcells_Human1.72564315
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72200326
43BCL6_27268052_Chip-Seq_Bcells_Human1.71840825
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.71780764
45FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71621263
46STAT1_17558387_ChIP-Seq_HELA_Human1.70521241
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.67131000
48MYC_22102868_ChIP-Seq_BL_Human1.65871511
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.64151847
50MAF_26560356_Chip-Seq_TH2_Human1.63897981
51GATA3_27048872_Chip-Seq_THYMUS_Human1.63550542
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62924281
53KAP1_22055183_ChIP-Seq_ESCs_Mouse1.62654477
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61911053
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61615476
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.61582259
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61371865
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60652996
59TCF7_22412390_ChIP-Seq_EML_Mouse1.59211346
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59079395
61MYB_26560356_Chip-Seq_TH1_Human1.58311500
62CBP_20019798_ChIP-Seq_JUKART_Human1.57096356
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57096356
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54131706
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51851936
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49485592
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.49115851
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47971009
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47703526
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47311554
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.46604387
72* TP63_22573176_ChIP-Seq_HFKS_Human1.46234995
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46023583
74* NFE2_27457419_Chip-Seq_LIVER_Mouse1.44847370
75P300_27268052_Chip-Seq_Bcells_Human1.44543414
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.43643530
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43132255
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42299147
79KDM2B_26808549_Chip-Seq_REH_Human1.41397384
80STAT1_20625510_ChIP-Seq_HELA_Human1.39519268
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.38641322
82PHF8_20622854_ChIP-Seq_HELA_Human1.38337263
83E2F1_20622854_ChIP-Seq_HELA_Human1.37943266
84* CBX2_27304074_Chip-Seq_ESCs_Mouse1.36556038
85GATA3_21867929_ChIP-Seq_CD8_Mouse1.36009981
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35789048
87RUNX1_26923725_Chip-Seq_HPCs_Mouse1.35534554
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35276527
89SMRT_27268052_Chip-Seq_Bcells_Human1.33199460
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.32097331
91FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29050815
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.28058481
93GF1_26923725_Chip-Seq_HPCs_Mouse1.27450123
94LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26434421
95KDM2B_26808549_Chip-Seq_DND41_Human1.25664657
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24355311
97YY1_22570637_ChIP-Seq_MALME-3M_Human1.23184964
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22208607
99* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22064030
100GATA2_19941826_ChIP-Seq_K562_Human1.21895347
101RNF2_27304074_Chip-Seq_NSC_Mouse1.21881121
102GATA3_21867929_ChIP-Seq_TH1_Mouse1.21834581
103RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21456862
104VDR_24787735_ChIP-Seq_THP-1_Human1.21273514
105SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21209956
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20794362
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20019945
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19360488
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.19238263
110SPI1_26923725_Chip-Seq_HPCs_Mouse1.17825259
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17576849
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17044371
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16544290
114TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16392826
115RACK7_27058665_Chip-Seq_MCF-7_Human1.16046505
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15940522
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15940522
118P53_21459846_ChIP-Seq_SAOS-2_Human1.15432552
119SA1_27219007_Chip-Seq_ERYTHROID_Human1.14919570
120ERA_21632823_ChIP-Seq_H3396_Human1.14748426
121CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14034812
122* OCT4_18555785_Chip-Seq_ESCs_Mouse1.13220867
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13021148
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.12770310
125* CRX_20693478_ChIP-Seq_RETINA_Mouse1.11212425
126AHR_22903824_ChIP-Seq_MCF-7_Human1.10953976
127CTCF_20526341_ChIP-Seq_ESCs_Human1.10778588
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10725429
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09962192
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09457978
131KLF5_25053715_ChIP-Seq_YYC3_Human1.09415338
132EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09082599
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08767372
134CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07869639
135SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07509427
136OCT4_20526341_ChIP-Seq_ESCs_Human1.06777654
137RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06311091
138GATA3_26560356_Chip-Seq_TH2_Human1.05984540
139* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05933693
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04163454
141RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03835116
142* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03737080
143ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03313048
144ESET_19884257_ChIP-Seq_ESCs_Mouse1.03297889
145OCT4_19829295_ChIP-Seq_ESCs_Human1.03195604
146* EZH2_27294783_Chip-Seq_NPCs_Mouse1.03046570
147* KLF4_18555785_Chip-Seq_ESCs_Mouse1.02995400
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02741694
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02199153
150* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02162543
151* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01763827
152CREB1_26743006_Chip-Seq_LNCaP_Human1.01605182
153CTCF_27219007_Chip-Seq_Bcells_Human1.01145282
154REST_21632747_ChIP-Seq_MESCs_Mouse1.00789710
155* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00429883
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00137782
157SPI1_23547873_ChIP-Seq_NB4_Human0.99799987
158* P300_18555785_Chip-Seq_ESCs_Mouse0.99433095
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.99030539
160ERG_20517297_ChIP-Seq_VCAP_Human0.98883848
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98650864
162GF1B_26923725_Chip-Seq_HPCs_Mouse0.97735978
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97392189
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97373056
165CEBPB_22108803_ChIP-Seq_LS180_Human0.97189905
166* P53_22387025_ChIP-Seq_ESCs_Mouse0.97085212
167CMYC_18555785_Chip-Seq_ESCs_Mouse0.96765422
168SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95894268
169SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95659263
170* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94525447
171CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94518350
172BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.94413532
173ESR2_21235772_ChIP-Seq_MCF-7_Human0.94384341
174* STAT3_18555785_Chip-Seq_ESCs_Mouse0.94339914
175MYC_27129775_Chip-Seq_CORNEA_Mouse0.93603667
176STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93400436
177CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92829758
178NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92521671
179PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92495981
180RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90937939
181* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90506251
182* CTCF_18555785_Chip-Seq_ESCs_Mouse0.90108239
183NFYB_21822215_ChIP-Seq_K562_Human0.89246487
184STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88937874
185NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88133778
186PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87684185
187RARA_24833708_ChIP-Seq_LIVER_Mouse0.87201959
188SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86542048
189ELF1_20517297_ChIP-Seq_JURKAT_Human0.85589221
190GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85437202
191SOX2_21211035_ChIP-Seq_LN229_Human0.85107219
192FLI1_21867929_ChIP-Seq_CD8_Mouse0.84873447
193* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83943746
194RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83433563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.83452088
2MP0001929_abnormal_gametogenesis5.41952023
3MP0008877_abnormal_DNA_methylation4.85734086
4MP0002132_abnormal_respiratory_system4.04013973
5MP0002210_abnormal_sex_determination3.65624092
6MP0002653_abnormal_ependyma_morphology3.57461970
7MP0002161_abnormal_fertility/fecundity3.16023692
8MP0001145_abnormal_male_reproductive3.12241129
9MP0005623_abnormal_meninges_morphology3.09843405
10MP0008875_abnormal_xenobiotic_pharmacok3.09786882
11MP0000653_abnormal_sex_gland2.69824295
12MP0003436_decreased_susceptibility_to2.49762426
13MP0002282_abnormal_trachea_morphology2.48364466
14MP0001800_abnormal_humoral_immune2.44513198
15MP0003646_muscle_fatigue2.33953491
16MP0001790_abnormal_immune_system2.32425203
17MP0005387_immune_system_phenotype2.32425203
18MP0004043_abnormal_pH_regulation2.30397402
19MP0005671_abnormal_response_to2.25948781
20MP0005670_abnormal_white_adipose2.19498022
21MP0005083_abnormal_biliary_tract2.13781135
22MP0005410_abnormal_fertilization15.0237471
23MP0005025_abnormal_response_to1.99390447
24MP0002723_abnormal_immune_serum1.98088287
25MP0005310_abnormal_salivary_gland1.94012044
26MP0010155_abnormal_intestine_physiology1.87966973
27MP0002452_abnormal_antigen_presenting1.87215562
28MP0002420_abnormal_adaptive_immunity1.86951869
29MP0002277_abnormal_respiratory_mucosa1.86646607
30MP0001819_abnormal_immune_cell1.84324568
31MP0002419_abnormal_innate_immunity1.76298897
32MP0003866_abnormal_defecation1.73927003
33MP0003303_peritoneal_inflammation1.73094273
34MP0002398_abnormal_bone_marrow1.69665648
35MP0005464_abnormal_platelet_physiology1.69085664
36MP0005000_abnormal_immune_tolerance1.66534776
37MP0000465_gastrointestinal_hemorrhage1.65902475
38MP0003172_abnormal_lysosome_physiology1.62893631
39MP0003724_increased_susceptibility_to1.55867613
40MP0000716_abnormal_immune_system1.54909518
41MP0004381_abnormal_hair_follicle1.49525272
42MP0002396_abnormal_hematopoietic_system1.49127664
43MP0002160_abnormal_reproductive_system1.47697370
44MP0008058_abnormal_DNA_repair1.47625097
45MP0000689_abnormal_spleen_morphology1.47260392
46MP0002722_abnormal_immune_system1.45004285
47MP0000703_abnormal_thymus_morphology1.41425498
48MP0002168_other_aberrant_phenotype1.40574717
49MP0009046_muscle_twitch1.39776751
50MP0004134_abnormal_chest_morphology1.31409854
51MP0004133_heterotaxia1.27082149
52MP0005451_abnormal_body_composition1.27056608
53MP0008961_abnormal_basal_metabolism1.27030571
54MP0009333_abnormal_splenocyte_physiolog1.26707601
55MP0004947_skin_inflammation1.26090004
56MP0002429_abnormal_blood_cell1.25860284
57MP0009785_altered_susceptibility_to1.24605990
58MP0008057_abnormal_DNA_replication1.20528295
59MP0006082_CNS_inflammation1.20253914
60MP0002148_abnormal_hypersensitivity_rea1.14776296
61MP0001845_abnormal_inflammatory_respons1.11883274
62MP0004019_abnormal_vitamin_homeostasis1.10309263
63MP0001986_abnormal_taste_sensitivity1.06070716
64MP0005423_abnormal_somatic_nervous1.02474494
65MP0000383_abnormal_hair_follicle1.02002670
66MP0000569_abnormal_digit_pigmentation1.01971516
67MP0010094_abnormal_chromosome_stability1.01146532
68MP0001533_abnormal_skeleton_physiology0.98473553
69MP0004233_abnormal_muscle_weight0.96731238
70MP0004883_abnormal_blood_vessel0.95092065
71MP0000678_abnormal_parathyroid_gland0.92248864
72MP0002166_altered_tumor_susceptibility0.90440127
73MP0001765_abnormal_ion_homeostasis0.90429076
74MP0008469_abnormal_protein_level0.89839415
75MP0003011_delayed_dark_adaptation0.89655233
76MP0002136_abnormal_kidney_physiology0.88821046
77MP0003943_abnormal_hepatobiliary_system0.88181796
78MP0001984_abnormal_olfaction0.85012381
79MP0000249_abnormal_blood_vessel0.83546034
80MP0001853_heart_inflammation0.83511491
81MP0001663_abnormal_digestive_system0.82589339
82MP0001501_abnormal_sleep_pattern0.82486088
83MP0009764_decreased_sensitivity_to0.80871103
84MP0009643_abnormal_urine_homeostasis0.80783013
85MP0005647_abnormal_sex_gland0.80072085
86MP0000858_altered_metastatic_potential0.79115915
87MP0003950_abnormal_plasma_membrane0.78565868
88MP0003300_gastrointestinal_ulcer0.76649333
89MP0002249_abnormal_larynx_morphology0.75796904
90MP0005389_reproductive_system_phenotype0.73823389
91MP0005164_abnormal_response_to0.72279540
92MP0002998_abnormal_bone_remodeling0.71402249
93MP0003786_premature_aging0.71399073
94MP0005220_abnormal_exocrine_pancreas0.71059963
95MP0001348_abnormal_lacrimal_gland0.70870035
96MP0002693_abnormal_pancreas_physiology0.70550396
97MP0005395_other_phenotype0.69711855
98MP0002638_abnormal_pupillary_reflex0.69524943
99MP0008007_abnormal_cellular_replicative0.68924158
100MP0001851_eye_inflammation0.67841815
101MP0009763_increased_sensitivity_to0.67788070
102MP0004130_abnormal_muscle_cell0.67191800
103MP0010386_abnormal_urinary_bladder0.64553844
104MP0008995_early_reproductive_senescence0.64242298
105MP0008789_abnormal_olfactory_epithelium0.64213037
106MP0003252_abnormal_bile_duct0.63044713
107MP0002909_abnormal_adrenal_gland0.62887951
108MP0002933_joint_inflammation0.61653398
109MP0000685_abnormal_immune_system0.58851198
110MP0003111_abnormal_nucleus_morphology0.58048170
111MP0005397_hematopoietic_system_phenotyp0.55368120
112MP0001545_abnormal_hematopoietic_system0.55368120
113MP0003787_abnormal_imprinting0.53137371
114MP0009278_abnormal_bone_marrow0.51950922
115MP0004808_abnormal_hematopoietic_stem0.51563278
116MP0003699_abnormal_female_reproductive0.50767143
117MP0002234_abnormal_pharynx_morphology0.49606959
118MP0003115_abnormal_respiratory_system0.47712169
119MP0010307_abnormal_tumor_latency0.46937497
120MP0000427_abnormal_hair_cycle0.45904171
121MP0005503_abnormal_tendon_morphology0.45472935
122MP0002971_abnormal_brown_adipose0.45146533
123MP0009250_abnormal_appendicular_skeleto0.45145720
124MP0000358_abnormal_cell_content/0.44291544
125MP0001119_abnormal_female_reproductive0.44090833
126MP0005377_hearing/vestibular/ear_phenot0.43698083
127MP0003878_abnormal_ear_physiology0.43698083
128MP0001324_abnormal_eye_pigmentation0.43081584
129MP0001293_anophthalmia0.42962792
130MP0002109_abnormal_limb_morphology0.41964205
131MP0002115_abnormal_skeleton_extremities0.40190541
132MP0005636_abnormal_mineral_homeostasis0.38834340
133MP0002928_abnormal_bile_duct0.37696318
134MP0005076_abnormal_cell_differentiation0.37456999
135MP0002405_respiratory_system_inflammati0.37368725
136MP0005666_abnormal_adipose_tissue0.35949817
137MP0000432_abnormal_head_morphology0.33931928
138MP0005253_abnormal_eye_physiology0.33868152
139MP0002116_abnormal_craniofacial_bone0.32526222
140MP0001730_embryonic_growth_arrest0.31051471
141MP0009115_abnormal_fat_cell0.30948879
142MP0005391_vision/eye_phenotype0.30597295
143MP0005174_abnormal_tail_pigmentation0.30560336
144MP0004036_abnormal_muscle_relaxation0.30339298
145MP0001764_abnormal_homeostasis0.27747233
146MP0000313_abnormal_cell_death0.27382312
147MP0002163_abnormal_gland_morphology0.26532667
148MP0003763_abnormal_thymus_physiology0.25134649
149MP0000534_abnormal_ureter_morphology0.24179635
150MP0002084_abnormal_developmental_patter0.23747188
151MP0003861_abnormal_nervous_system0.23273053
152MP0003329_amyloid_beta_deposits0.22917620
153MP0002102_abnormal_ear_morphology0.21800492
154MP0001919_abnormal_reproductive_system0.21735021
155MP0001835_abnormal_antigen_presentation0.21490569
156MP0000163_abnormal_cartilage_morphology0.21488130
157MP0001542_abnormal_bone_strength0.21143453
158MP0003942_abnormal_urinary_system0.21107959
159MP0000751_myopathy0.20265234
160MP0001873_stomach_inflammation0.19814525
161MP0003959_abnormal_lean_body0.19369440
162MP0006072_abnormal_retinal_apoptosis0.19307522
163MP0002108_abnormal_muscle_morphology0.18893523
164MP0003077_abnormal_cell_cycle0.18798964
165MP0002114_abnormal_axial_skeleton0.17931223
166MP0002113_abnormal_skeleton_development0.17531275
167MP0005551_abnormal_eye_electrophysiolog0.17228880
168MP0002269_muscular_atrophy0.17190349
169MP0002092_abnormal_eye_morphology0.16924514
170MP0003045_fibrosis0.16544555
171MP0003656_abnormal_erythrocyte_physiolo0.16436632
172MP0003879_abnormal_hair_cell0.15712137
173MP0001697_abnormal_embryo_size0.13612347
174MP0004197_abnormal_fetal_growth/weight/0.13447404
175MP0002169_no_abnormal_phenotype0.13301649

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.87434398
2Abnormal respiratory motile cilium morphology (HP:0005938)7.89678887
3Abnormal respiratory epithelium morphology (HP:0012253)7.89678887
4Rhinitis (HP:0012384)7.59842947
5Abnormal ciliary motility (HP:0012262)7.13864770
6Chronic bronchitis (HP:0004469)6.70759726
7Nasal polyposis (HP:0100582)6.51034874
8Infertility (HP:0000789)5.89675947
9Abnormality of the nasal mucosa (HP:0000433)5.31963708
10Bronchitis (HP:0012387)4.65009056
11Bronchiectasis (HP:0002110)4.55098975
12Nephronophthisis (HP:0000090)4.22615763
13Male infertility (HP:0003251)3.88968621
14Recurrent otitis media (HP:0000403)3.52459732
15Chronic otitis media (HP:0000389)3.45351481
16Irregular epiphyses (HP:0010582)3.30568702
17Recurrent sinusitis (HP:0011108)3.29790626
18Recurrent bronchitis (HP:0002837)3.27841942
19Abnormality of the renal medulla (HP:0100957)3.18251150
20Abnormal spermatogenesis (HP:0008669)3.10121153
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.93173392
22Absent epiphyses (HP:0010577)2.93173392
23Absent frontal sinuses (HP:0002688)2.87853414
24Fibular hypoplasia (HP:0003038)2.84842801
25Chronic hepatic failure (HP:0100626)2.82904600
26Epiphyseal dysplasia (HP:0002656)2.77334478
27Abnormality of the lower motor neuron (HP:0002366)2.75838677
28Occipital encephalocele (HP:0002085)2.69593974
29Tubular atrophy (HP:0000092)2.68483573
30True hermaphroditism (HP:0010459)2.65705355
31Abnormality of midbrain morphology (HP:0002418)2.63131108
32Molar tooth sign on MRI (HP:0002419)2.63131108
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.62970303
34Atelectasis (HP:0100750)2.62688695
35Pancreatic cysts (HP:0001737)2.53265842
36Tubulointerstitial nephritis (HP:0001970)2.52009237
37Colitis (HP:0002583)2.49967691
38Vitreoretinal degeneration (HP:0000655)2.47546725
39Short femoral neck (HP:0100864)2.44400101
40Short ribs (HP:0000773)2.36758829
41Impulsivity (HP:0100710)2.33186637
42Small epiphyses (HP:0010585)2.31719450
43Tubulointerstitial abnormality (HP:0001969)2.30490996
44Gonadotropin excess (HP:0000837)2.30305594
45Decreased circulating renin level (HP:0003351)2.29133467
46Hyperkalemia (HP:0002153)2.24744879
47Elevated erythrocyte sedimentation rate (HP:0003565)2.24424509
48Hyperactive renin-angiotensin system (HP:0000841)2.24303655
49Medial flaring of the eyebrow (HP:0010747)2.19077660
50Azoospermia (HP:0000027)2.16865082
51Microglossia (HP:0000171)2.16726194
52Severe visual impairment (HP:0001141)2.14675871
53Amyotrophic lateral sclerosis (HP:0007354)2.11123550
54Postaxial foot polydactyly (HP:0001830)2.10601196
55Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.10428508
56Panhypogammaglobulinemia (HP:0003139)2.04739262
57Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04172673
58Flattened epiphyses (HP:0003071)2.03870615
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.01354705
60Tubulointerstitial fibrosis (HP:0005576)2.00442998
61Recurrent fungal infections (HP:0002841)2.00222828
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3501932
63Dynein arm defect of respiratory motile cilia (HP:0012255)11.4631978
64Absent/shortened dynein arms (HP:0200106)11.4631978
65Flat acetabular roof (HP:0003180)1.99465763
66Recurrent cutaneous fungal infections (HP:0011370)1.99395863
67Chronic mucocutaneous candidiasis (HP:0002728)1.99395863
68Inflammation of the large intestine (HP:0002037)1.96490668
69Recurrent abscess formation (HP:0002722)1.92579802
70Increased neuronal autofluorescent lipopigment (HP:0002074)1.91276695
71Abnormality of femoral epiphyses (HP:0006499)1.90786425
72Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90786425
73Abnormal delayed hypersensitivity skin test (HP:0002963)1.90131361
74Gastrointestinal inflammation (HP:0004386)1.88512842
75Congenital hepatic fibrosis (HP:0002612)1.87221442
76Prolonged bleeding time (HP:0003010)1.86849342
77Chronic sinusitis (HP:0011109)1.84718770
78Hypoplastic ischia (HP:0003175)1.84142105
79Agammaglobulinemia (HP:0004432)1.81402938
80Cupped ribs (HP:0000887)1.81138324
81Abnormality of the epiphysis of the femoral head (HP:0010574)1.80578755
82Eczematoid dermatitis (HP:0000976)1.79734822
83Abnormality of dentin (HP:0010299)1.79156433
84Abnormal rod and cone electroretinograms (HP:0008323)1.79007711
85Aplasia/Hypoplasia of the fibula (HP:0006492)1.78483433
86Stage 5 chronic kidney disease (HP:0003774)1.78270421
87Stomatitis (HP:0010280)1.78153470
88Abnormal tarsal ossification (HP:0008369)1.78019303
89Decreased central vision (HP:0007663)1.77651505
90Myositis (HP:0100614)1.76690124
91Recurrent bacterial skin infections (HP:0005406)1.76085664
92Polydipsia (HP:0001959)1.75697190
93Abnormal drinking behavior (HP:0030082)1.75697190
94Genetic anticipation (HP:0003743)1.74854778
95Abnormality of the fingertips (HP:0001211)1.74781361
96Short thorax (HP:0010306)1.74589941
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74299276
98Increased cerebral lipofuscin (HP:0011813)1.72726401
99Median cleft lip (HP:0000161)1.71972588
100Abnormality of the renal cortex (HP:0011035)1.70164175
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66931405
102Recurrent viral infections (HP:0004429)1.65312042
103Obstructive sleep apnea (HP:0002870)1.64705019
104Increased IgE level (HP:0003212)1.64653131
105J-shaped sella turcica (HP:0002680)1.63440926
106Impaired proprioception (HP:0010831)1.61423954
107Facial cleft (HP:0002006)1.61295099
108Heterotopia (HP:0002282)1.60296233
109Abnormality of the femoral head (HP:0003368)1.57062484
110Abnormality of the ischium (HP:0003174)1.56516648
111Abnormality of the frontal sinuses (HP:0002687)1.55821283
112Oculomotor apraxia (HP:0000657)1.55646246
113Asplenia (HP:0001746)1.55639512
114Renal dysplasia (HP:0000110)1.54418627
115Degeneration of anterior horn cells (HP:0002398)1.54193095
116Abnormality of the anterior horn cell (HP:0006802)1.54193095
117Absent rod-and cone-mediated responses on ERG (HP:0007688)1.54175324
118Anencephaly (HP:0002323)1.54149176
119Cone-rod dystrophy (HP:0000548)1.53404946
120Postaxial hand polydactyly (HP:0001162)1.53324408
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.52655000
122Aplasia/hypoplasia of the femur (HP:0005613)1.51091883
123Lip pit (HP:0100267)1.50953694
124Pancreatic fibrosis (HP:0100732)1.50126882
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.49818493
126Bony spicule pigmentary retinopathy (HP:0007737)1.49710484
127Aplasia/Hypoplasia of the spleen (HP:0010451)1.49104385
128Recurrent skin infections (HP:0001581)1.48966270
129Meningitis (HP:0001287)1.48610470
130Spastic tetraparesis (HP:0001285)1.48452448
13111 pairs of ribs (HP:0000878)1.48037789
132Abnormality of chloride homeostasis (HP:0011422)1.47275932
133Abnormality of T cell physiology (HP:0011840)1.47032842
134Bell-shaped thorax (HP:0001591)1.46430591
135Delayed epiphyseal ossification (HP:0002663)1.46010719
136Attenuation of retinal blood vessels (HP:0007843)1.45890882
137Recurrent pneumonia (HP:0006532)1.43733000
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.43382439
139Male pseudohermaphroditism (HP:0000037)1.42781718
140Abnormality of renin-angiotensin system (HP:0000847)1.42528859
141Abnormality of T cells (HP:0002843)1.42426658
142Glucose intolerance (HP:0000833)1.42396262
143Deformed sella turcica (HP:0002681)1.42396069
144Abnormality of renal excretion (HP:0011036)1.41941775
145Taurodontia (HP:0000679)1.41574310
146Abnormality of permanent molar morphology (HP:0011071)1.41574310
147Abnormality of the dental root (HP:0006486)1.41574310
148Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.40529789
149Upper motor neuron abnormality (HP:0002127)1.39692465
150Recurrent gram-negative bacterial infections (HP:0005420)1.39485346
151Abnormality of saccadic eye movements (HP:0000570)1.38364611
152Epistaxis (HP:0000421)1.37754617
153Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.37095400
154Tongue fasciculations (HP:0001308)1.35510440
155Renal salt wasting (HP:0000127)1.35054368
156Hypoplasia of the thymus (HP:0000778)1.34707894
157Encephalitis (HP:0002383)1.34087641
158Cystic liver disease (HP:0006706)1.33725084
159Dyschromatopsia (HP:0007641)1.33196747
160Hyponatremia (HP:0002902)1.32956256
161Self-mutilation (HP:0000742)1.32148992
162Abnormal biliary tract physiology (HP:0012439)1.31539471
163Bile duct proliferation (HP:0001408)1.31539471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.16847325
2PDK38.16847325
3PDK25.37646520
4PRKD35.36539531
5TESK15.25882170
6ICK3.51224217
7PTK2B2.84502139
8WNK42.52840349
9STK392.34526198
10PNCK2.31386771
11ACVR1B2.22370468
12FRK2.21039488
13BLK2.10019761
14TNK21.93963180
15EPHA21.89967400
16STK381.83649539
17GRK61.82044720
18MST41.75115445
19TYK21.75007733
20TAOK31.71782450
21NEK21.69729221
22MAP2K31.65687176
23MAP3K71.62800539
24SMG11.61035954
25PRPF4B1.58190301
26BTK1.56521143
27TXK1.52011200
28FES1.34626605
29ERN11.33240864
30ITK1.32438774
31SIK21.26252629
32HIPK21.24163588
33KIT1.12258544
34TEC1.12251194
35DYRK1B1.10679534
36JAK31.09125613
37SYK1.07985486
38IKBKE1.07171644
39TYRO31.06976306
40MAPK111.06206675
41EPHB11.05465191
42HCK1.03865840
43JAK11.00199957
44EEF2K0.99873196
45MAPK150.99093569
46PDK10.96672339
47BRD40.96567046
48STK30.94906391
49MST1R0.92285369
50WNK10.92181943
51TTK0.90750618
52PASK0.90056018
53CDC42BPA0.89123663
54IKBKB0.87361072
55PRKD20.86399139
56MAP3K20.84607250
57LCK0.79861340
58MAP2K20.78041287
59LYN0.77657267
60CDC70.76194117
61CHUK0.75576982
62IRAK40.74576356
63TLK10.74386505
64FGFR30.74320559
65MELK0.71524735
66CCNB10.71078642
67DYRK30.70381525
68WEE10.70302206
69FGFR40.68151939
70PRKAA20.67335655
71MAP3K140.67150397
72MAP3K130.67046385
73MAPK120.64563770
74STK38L0.64305556
75MAP3K110.62756338
76CDK40.62494450
77SIK10.62039474
78PRKG20.60845386
79LMTK20.60556164
80NLK0.57448353
81INSRR0.56597992
82CHEK10.55692186
83BRSK20.55185757
84CHEK20.55075900
85CAMK1D0.55012481
86RET0.54202105
87IRAK10.52124815
88CDK120.51659329
89CAMK1G0.50144343
90ZAP700.46592837
91PTK60.46556521
92ATR0.46249134
93RPS6KA60.46199017
94ERBB20.45960552
95PKN20.44079674
96MAP4K20.43089514
97MAPK70.42854769
98EPHA30.42119055
99MATK0.41646948
100DDR20.41351395
101LRRK20.40855288
102PDPK10.38691668
103RPS6KA20.38272059
104CAMKK10.37671217
105ATM0.37537640
106MUSK0.37451530
107RPS6KL10.37075650
108RPS6KC10.37075650
109PLK40.35486819
110MTOR0.34295909
111NTRK20.33244553
112STK100.33241547
113TRIB30.31627564
114PLK10.29461443
115PDGFRB0.28443288
116PAK10.27605720
117IRAK20.27268855
118PAK20.26886428
119MARK20.26825123
120MAP2K60.25472650
121PRKAA10.25135793
122RPS6KB10.24167759
123TESK20.22017477
124TAOK10.21650659
125MAP4K10.20684250
126MAP2K70.20541849
127NEK60.19641558
128BRSK10.19347317
129PINK10.19116266
130MAPKAPK50.19079320
131PRKCG0.18570959
132CSK0.17812143
133ERBB30.16402754
134BMPR1B0.15939389
135TRPM70.13825527
136PRKCQ0.12635852
137CSF1R0.12343887
138RIPK10.11555802
139CDK10.11066554
140CDK20.10609421
141MAPK80.10267943
142RIPK40.09885444
143GSK3B0.08219516
144MAPK100.08170306
145MAP3K30.07679240
146STK110.07564135
147CSNK2A10.07552273
148PRKDC0.07155056
149MARK30.06829568
150NME10.06809243
151MAP3K100.06605299
152CLK10.06270579
153PRKG10.06010147
154CSNK2A20.05523912
155PRKACG0.05443419
156YES10.04931962
157TBK10.04467968
158PRKCZ0.04397595
159INSR0.03314785
160RPS6KA10.02984274
161CDK90.02863652
162MAPK10.02483892
163EGFR0.02049227
164CSNK1D0.01057429
165MAPKAPK30.00989806
166GRK10.00081546
167CDK15-0.0017407

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.01688470
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.97269392
3Pyruvate metabolism_Homo sapiens_hsa006203.67126949
4Fatty acid biosynthesis_Homo sapiens_hsa000613.45354025
5Pentose phosphate pathway_Homo sapiens_hsa000303.26460725
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.84794617
7Primary immunodeficiency_Homo sapiens_hsa053402.81409675
8Linoleic acid metabolism_Homo sapiens_hsa005912.77373762
9Dorso-ventral axis formation_Homo sapiens_hsa043202.71059951
10Glucagon signaling pathway_Homo sapiens_hsa049222.70359175
11Propanoate metabolism_Homo sapiens_hsa006402.59428211
12Basal transcription factors_Homo sapiens_hsa030222.56831366
13Fanconi anemia pathway_Homo sapiens_hsa034602.31600504
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.22755161
15Selenocompound metabolism_Homo sapiens_hsa004502.02993527
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.01010827
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.99292448
18Histidine metabolism_Homo sapiens_hsa003401.98830960
19Graft-versus-host disease_Homo sapiens_hsa053321.96934644
20Phenylalanine metabolism_Homo sapiens_hsa003601.93175973
21Glycerolipid metabolism_Homo sapiens_hsa005611.88014316
22Allograft rejection_Homo sapiens_hsa053301.86843812
23Autoimmune thyroid disease_Homo sapiens_hsa053201.82877300
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.77657672
25Oocyte meiosis_Homo sapiens_hsa041141.76106878
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73011079
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65614060
28Hematopoietic cell lineage_Homo sapiens_hsa046401.65165456
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61620524
30PPAR signaling pathway_Homo sapiens_hsa033201.57365917
31Amphetamine addiction_Homo sapiens_hsa050311.53317105
32Renin-angiotensin system_Homo sapiens_hsa046141.50630777
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47054780
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.46086887
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.45632588
36Acute myeloid leukemia_Homo sapiens_hsa052211.42355738
37Huntingtons disease_Homo sapiens_hsa050161.42247527
38Type I diabetes mellitus_Homo sapiens_hsa049401.42240977
39Antigen processing and presentation_Homo sapiens_hsa046121.41343970
40Notch signaling pathway_Homo sapiens_hsa043301.39025787
41Tyrosine metabolism_Homo sapiens_hsa003501.38073654
42RNA transport_Homo sapiens_hsa030131.37229342
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.37184667
44mRNA surveillance pathway_Homo sapiens_hsa030151.36855491
45Osteoclast differentiation_Homo sapiens_hsa043801.35763977
46Protein digestion and absorption_Homo sapiens_hsa049741.34476383
47Leishmaniasis_Homo sapiens_hsa051401.32616744
48Carbon metabolism_Homo sapiens_hsa012001.32003004
49Staphylococcus aureus infection_Homo sapiens_hsa051501.31742385
50Renin secretion_Homo sapiens_hsa049241.29004112
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26566172
52Other glycan degradation_Homo sapiens_hsa005111.26148486
53Fructose and mannose metabolism_Homo sapiens_hsa000511.25361833
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.22492022
55Measles_Homo sapiens_hsa051621.20680984
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19232687
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17374805
58Biosynthesis of amino acids_Homo sapiens_hsa012301.14137049
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12974195
60Ether lipid metabolism_Homo sapiens_hsa005651.11161784
61Fat digestion and absorption_Homo sapiens_hsa049751.10962511
62Asthma_Homo sapiens_hsa053101.09221244
63Influenza A_Homo sapiens_hsa051641.08409644
64Platelet activation_Homo sapiens_hsa046111.07186909
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.05315063
66Hepatitis C_Homo sapiens_hsa051601.03299168
67Toxoplasmosis_Homo sapiens_hsa051451.03130841
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02461931
69Herpes simplex infection_Homo sapiens_hsa051681.01729013
70Lysine degradation_Homo sapiens_hsa003101.00564334
71Choline metabolism in cancer_Homo sapiens_hsa052311.00215084
72Tuberculosis_Homo sapiens_hsa051520.98271082
73Non-small cell lung cancer_Homo sapiens_hsa052230.97472646
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97460952
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97318514
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96822255
77beta-Alanine metabolism_Homo sapiens_hsa004100.96471711
78Mineral absorption_Homo sapiens_hsa049780.96449678
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95165146
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94634086
81Insulin resistance_Homo sapiens_hsa049310.93578445
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91576227
83TNF signaling pathway_Homo sapiens_hsa046680.87272701
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83843213
85Estrogen signaling pathway_Homo sapiens_hsa049150.82169609
86Retinol metabolism_Homo sapiens_hsa008300.82057705
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80871658
88Purine metabolism_Homo sapiens_hsa002300.78912129
89Pancreatic cancer_Homo sapiens_hsa052120.77460615
90Fatty acid degradation_Homo sapiens_hsa000710.74414956
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.73947954
92Cardiac muscle contraction_Homo sapiens_hsa042600.72702525
93Viral myocarditis_Homo sapiens_hsa054160.71426430
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.71024734
95Hepatitis B_Homo sapiens_hsa051610.70151298
96Fatty acid metabolism_Homo sapiens_hsa012120.69978533
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69766834
98ABC transporters_Homo sapiens_hsa020100.69725726
99ECM-receptor interaction_Homo sapiens_hsa045120.69025207
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68855972
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68488213
102mTOR signaling pathway_Homo sapiens_hsa041500.68040666
103Taste transduction_Homo sapiens_hsa047420.67581222
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67578626
105Long-term potentiation_Homo sapiens_hsa047200.67317878
106Chemokine signaling pathway_Homo sapiens_hsa040620.66998223
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65612782
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64781887
109Chronic myeloid leukemia_Homo sapiens_hsa052200.63962021
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62639956
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.61155557
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59588936
113Apoptosis_Homo sapiens_hsa042100.58981947
114Arachidonic acid metabolism_Homo sapiens_hsa005900.58371452
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57418511
116Malaria_Homo sapiens_hsa051440.57205090
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56044207
118AMPK signaling pathway_Homo sapiens_hsa041520.55869281
119Type II diabetes mellitus_Homo sapiens_hsa049300.55839330
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55554161
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55069141
122Endocytosis_Homo sapiens_hsa041440.54711560
123Thyroid hormone synthesis_Homo sapiens_hsa049180.54458814
124Lysosome_Homo sapiens_hsa041420.54328823
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.53414200
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53342017
127Insulin secretion_Homo sapiens_hsa049110.52096813
128Hedgehog signaling pathway_Homo sapiens_hsa043400.52079020
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.51806799
130B cell receptor signaling pathway_Homo sapiens_hsa046620.51029575
131RNA degradation_Homo sapiens_hsa030180.50656217
132Viral carcinogenesis_Homo sapiens_hsa052030.48340462
133FoxO signaling pathway_Homo sapiens_hsa040680.45709260
134Calcium signaling pathway_Homo sapiens_hsa040200.45383514
135Pancreatic secretion_Homo sapiens_hsa049720.45317953
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44946733
137Sphingolipid metabolism_Homo sapiens_hsa006000.44150403
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.44014574
139VEGF signaling pathway_Homo sapiens_hsa043700.43763257
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43756276
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43705276
142Homologous recombination_Homo sapiens_hsa034400.43685062
143T cell receptor signaling pathway_Homo sapiens_hsa046600.43251636
144Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41172387
145MAPK signaling pathway_Homo sapiens_hsa040100.40672066
146Inositol phosphate metabolism_Homo sapiens_hsa005620.40587669
147Prolactin signaling pathway_Homo sapiens_hsa049170.39606529
148Legionellosis_Homo sapiens_hsa051340.39178395
149Systemic lupus erythematosus_Homo sapiens_hsa053220.39076899
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38632252
151Olfactory transduction_Homo sapiens_hsa047400.38510578
152Glutathione metabolism_Homo sapiens_hsa004800.38355910
153Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35640331
154Cocaine addiction_Homo sapiens_hsa050300.32694506
155Salivary secretion_Homo sapiens_hsa049700.31437879
156N-Glycan biosynthesis_Homo sapiens_hsa005100.30453431
157Bile secretion_Homo sapiens_hsa049760.29886069
158Chemical carcinogenesis_Homo sapiens_hsa052040.28592613
159cAMP signaling pathway_Homo sapiens_hsa040240.27188189
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26940262
161Cell cycle_Homo sapiens_hsa041100.24486833
162Wnt signaling pathway_Homo sapiens_hsa043100.23155942
163Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22477869
164Gastric acid secretion_Homo sapiens_hsa049710.21315369
165Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20888379
166HTLV-I infection_Homo sapiens_hsa051660.20845301
167Vascular smooth muscle contraction_Homo sapiens_hsa042700.20804361
168Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20173889
169Metabolic pathways_Homo sapiens_hsa011000.18314905
170Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17994460

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