ANKRD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.12456691
2semaphorin-plexin signaling pathway (GO:0071526)4.09927239
3histone H3-K4 trimethylation (GO:0080182)3.99130054
4nuclear pore complex assembly (GO:0051292)3.95662687
5cytoplasmic mRNA processing body assembly (GO:0033962)3.79833695
6mitotic sister chromatid cohesion (GO:0007064)3.52852031
7atrioventricular valve morphogenesis (GO:0003181)3.48595179
8activation of Rac GTPase activity (GO:0032863)3.44688085
9nuclear pore organization (GO:0006999)3.41440762
10cell-cell junction maintenance (GO:0045217)3.40861899
11histone H3-K4 methylation (GO:0051568)3.32123807
12negative regulation of histone methylation (GO:0031061)3.28433937
13neural tube development (GO:0021915)3.23098451
14endothelial cell chemotaxis (GO:0035767)3.09179458
15mannose metabolic process (GO:0006013)3.08654692
16regulation of histone H3-K27 methylation (GO:0061085)3.08076639
17establishment or maintenance of monopolar cell polarity (GO:0061339)3.05064191
18establishment of monopolar cell polarity (GO:0061162)3.05064191
19negative regulation of translation, ncRNA-mediated (GO:0040033)3.04866070
20regulation of translation, ncRNA-mediated (GO:0045974)3.04866070
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04866070
22pore complex assembly (GO:0046931)3.02696683
23cytoskeletal anchoring at plasma membrane (GO:0007016)3.02466574
24positive regulation of protein deacetylation (GO:0090312)2.98549396
25positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.96787991
26cell migration in hindbrain (GO:0021535)2.92344625
27camera-type eye morphogenesis (GO:0048593)2.90586004
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88842534
29mitochondrion transport along microtubule (GO:0047497)2.88842534
30convergent extension (GO:0060026)2.87379281
31NLS-bearing protein import into nucleus (GO:0006607)2.86430457
32regulation of RNA export from nucleus (GO:0046831)2.85267556
33regulation of DNA endoreduplication (GO:0032875)2.83834754
34histone lysine methylation (GO:0034968)2.83755042
35peptidyl-lysine trimethylation (GO:0018023)2.82352897
36heterochromatin organization (GO:0070828)2.82193870
37negative regulation of cell killing (GO:0031342)2.82125143
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.82125143
39positive regulation of CREB transcription factor activity (GO:0032793)2.81371829
40apoptotic process involved in morphogenesis (GO:0060561)2.80189483
41positive regulation of histone deacetylation (GO:0031065)2.80060010
42regulation of translational fidelity (GO:0006450)2.79450979
43positive regulation of gene expression, epigenetic (GO:0045815)2.78828922
44glucocorticoid receptor signaling pathway (GO:0042921)2.75909985
45positive thymic T cell selection (GO:0045059)2.70529023
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68671469
47regulation of histone deacetylation (GO:0031063)2.64876763
48negative regulation of erythrocyte differentiation (GO:0045647)2.64711645
49peptidyl-lysine dimethylation (GO:0018027)2.64176609
50positive T cell selection (GO:0043368)2.63229875
51thymic T cell selection (GO:0045061)2.61452810
52positive regulation by host of viral transcription (GO:0043923)2.61298165
53negative regulation of fatty acid transport (GO:2000192)2.60269108
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59805001
55regulation of nucleobase-containing compound transport (GO:0032239)2.59653378
56histone H3-K9 methylation (GO:0051567)2.59650933
57histone H4 deacetylation (GO:0070933)2.59081874
58collecting duct development (GO:0072044)2.59053929
59establishment of apical/basal cell polarity (GO:0035089)2.58287041
60heart valve formation (GO:0003188)2.56979297
61regulation of histone H3-K9 methylation (GO:0051570)2.56284117
62histone H3-K36 demethylation (GO:0070544)2.52205057
63regulation of protein deacetylation (GO:0090311)2.50856546
64regulation of posttranscriptional gene silencing (GO:0060147)2.49973061
65regulation of gene silencing by miRNA (GO:0060964)2.49973061
66regulation of gene silencing by RNA (GO:0060966)2.49973061
67eye morphogenesis (GO:0048592)2.49943060
68heart morphogenesis (GO:0003007)2.48101177
69T cell selection (GO:0045058)2.47339630
70regulation of chromatin binding (GO:0035561)2.47313697
71regulation of ARF protein signal transduction (GO:0032012)2.47029875
72adherens junction assembly (GO:0034333)2.46437759
73embryonic retina morphogenesis in camera-type eye (GO:0060059)2.45042282
74histone methylation (GO:0016571)2.43230992
75histone H4-K16 acetylation (GO:0043984)2.42832940
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.42594469
77peptidyl-lysine methylation (GO:0018022)2.42508066
78embryonic eye morphogenesis (GO:0048048)2.42434965
79regulation of establishment of planar polarity (GO:0090175)2.42205625
80vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41607770
81negative T cell selection (GO:0043383)2.41524712
82histone H3-K9 demethylation (GO:0033169)2.41427072
83histone H3-K9 modification (GO:0061647)2.40796080
84cell junction maintenance (GO:0034331)2.40032529
85RNA stabilization (GO:0043489)2.39987480
86mRNA stabilization (GO:0048255)2.39987480
87body morphogenesis (GO:0010171)2.39544255
88stress granule assembly (GO:0034063)2.39192351
89axon extension (GO:0048675)2.38764227
90negative thymic T cell selection (GO:0045060)2.38434069
91positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.38147823
92lung epithelium development (GO:0060428)2.37747127
93renal system development (GO:0072001)2.37581025
94corticosteroid receptor signaling pathway (GO:0031958)2.37543113
95G1 DNA damage checkpoint (GO:0044783)2.37336693
96positive regulation of blood vessel endothelial cell migration (GO:0043536)2.36853931
97regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.36767760
98positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.36767760
99regulation of mammary gland epithelial cell proliferation (GO:0033599)2.34919996
100bone trabecula formation (GO:0060346)2.34142955
101cochlea morphogenesis (GO:0090103)2.33803865
102histone H4-K12 acetylation (GO:0043983)2.32663877
103regulation of glucose import in response to insulin stimulus (GO:2001273)2.32435797
104plasma membrane repair (GO:0001778)2.31993679
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31954194
106positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.31574410
107regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.31574410
108cell-substrate junction assembly (GO:0007044)2.29678043
109intracellular estrogen receptor signaling pathway (GO:0030520)2.28574632
110neuron projection extension (GO:1990138)2.28267083
111chromatin assembly (GO:0031497)2.28146576
112hippo signaling (GO:0035329)2.27158767
113regulation of axon extension involved in axon guidance (GO:0048841)2.26510802
114cellular response to epidermal growth factor stimulus (GO:0071364)2.26494583
115positive regulation of synapse maturation (GO:0090129)2.26413794
116alternative mRNA splicing, via spliceosome (GO:0000380)2.26284300
117regulation of early endosome to late endosome transport (GO:2000641)2.26278304
118positive regulation of Rac GTPase activity (GO:0032855)2.26043321
119mitotic chromosome condensation (GO:0007076)2.26032279
120negative regulation of Ras protein signal transduction (GO:0046580)2.25877036
121dopamine receptor signaling pathway (GO:0007212)2.25827736
122focal adhesion assembly (GO:0048041)2.25382374
123cell-substrate adherens junction assembly (GO:0007045)2.25382374
124establishment of mitochondrion localization (GO:0051654)2.25283812
125histone H3 deacetylation (GO:0070932)2.25238520
126basement membrane organization (GO:0071711)2.25233978
127regulation of histone H3-K4 methylation (GO:0051569)2.24958164
128histone lysine demethylation (GO:0070076)2.24849619
129regulation of histone methylation (GO:0031060)2.23662647
130positive regulation of SMAD protein import into nucleus (GO:0060391)2.23659034
131mRNA splice site selection (GO:0006376)2.22137737
132peptidyl-threonine phosphorylation (GO:0018107)2.21799324
133chromatin silencing (GO:0006342)2.20329930
134negative regulation of histone modification (GO:0031057)2.19787586
135paraxial mesoderm development (GO:0048339)2.19592234
136regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.19241924
137determination of adult lifespan (GO:0008340)2.19114508
138neural tube closure (GO:0001843)2.18988687
139DNA duplex unwinding (GO:0032508)2.18216681
140DNA geometric change (GO:0032392)2.17529503
141positive regulation of RNA splicing (GO:0033120)2.17327722
142dosage compensation (GO:0007549)2.17196632
143tube closure (GO:0060606)2.16525607
144negative regulation of DNA repair (GO:0045738)2.15406570
145regulation of NFAT protein import into nucleus (GO:0051532)2.13853870
146negative regulation of chromatin modification (GO:1903309)2.11569789
147coronary vasculature morphogenesis (GO:0060977)2.11477005
148trophectodermal cell differentiation (GO:0001829)2.11469462
149peptidyl-threonine modification (GO:0018210)2.10964206
150histone demethylation (GO:0016577)2.10549742
151regulation of ARF GTPase activity (GO:0032312)2.09267978
152protein-DNA complex disassembly (GO:0032986)2.08302529
153nucleosome disassembly (GO:0006337)2.08302529
154regulation of gamma-delta T cell differentiation (GO:0045586)2.08148661
155regulation of sister chromatid cohesion (GO:0007063)2.08021648
156positive regulation of mRNA catabolic process (GO:0061014)2.07736129
157cerebellar Purkinje cell differentiation (GO:0021702)2.07267517
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.06940257
159regulation of hippo signaling (GO:0035330)2.06516163
160planar cell polarity pathway involved in neural tube closure (GO:0090179)2.05884254
161positive regulation of gamma-delta T cell activation (GO:0046645)2.04643358
162hemidesmosome assembly (GO:0031581)2.04306955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.13700084
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.93250683
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.52550489
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.34420176
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06781476
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99727164
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90711305
8MYC_22102868_ChIP-Seq_BL_Human2.88618688
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.71264752
10LXR_22292898_ChIP-Seq_THP-1_Human2.59235490
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56158661
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.46413204
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.46075313
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.42364668
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42049537
16KDM2B_26808549_Chip-Seq_DND41_Human2.40127987
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31715294
18TCF7_22412390_ChIP-Seq_EML_Mouse2.27915775
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25786824
20ZFP281_27345836_Chip-Seq_ESCs_Mouse2.14114948
21* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13175119
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.07270667
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02856325
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98963480
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.95630587
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.93030295
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88599026
28* KDM2B_26808549_Chip-Seq_JURKAT_Human1.83787989
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80777090
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76357703
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76313400
32KDM2B_26808549_Chip-Seq_K562_Human1.74301960
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.73981326
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70902800
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68337790
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67664475
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63962419
38P68_20966046_ChIP-Seq_HELA_Human1.61810536
39DROSHA_22980978_ChIP-Seq_HELA_Human1.60506246
40FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.58465124
41VDR_21846776_ChIP-Seq_THP-1_Human1.58328220
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.57731071
43ZNF263_19887448_ChIP-Seq_K562_Human1.56332658
44SMC4_20622854_ChIP-Seq_HELA_Human1.54777116
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53525480
46CTCF_27219007_Chip-Seq_Bcells_Human1.51141675
47* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48074148
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46840572
49* TP53_22127205_ChIP-Seq_IMR90_Human1.46751174
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46128886
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46085065
52RUNX_20019798_ChIP-Seq_JUKART_Human1.44625485
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.42241478
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39514156
55* TP53_16413492_ChIP-PET_HCT116_Human1.38937093
56* UTX_26944678_Chip-Seq_JUKART_Human1.37287423
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.36840689
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36143236
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36002189
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.35540575
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33577709
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33577709
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33577709
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32887387
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32475288
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32180529
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31384485
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30228156
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.29976545
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.29242609
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.28592678
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28539286
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27172967
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26170464
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25660835
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25471465
77MAF_26560356_Chip-Seq_TH1_Human1.24984258
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23248897
79* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21887854
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20707083
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19714526
82* TP53_23651856_ChIP-Seq_MEFs_Mouse1.17848212
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17547674
84* RUNX1_27514584_Chip-Seq_MCF-7_Human1.17294347
85* ATF3_27146783_Chip-Seq_COLON_Human1.17208781
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16937390
87AHR_22903824_ChIP-Seq_MCF-7_Human1.16437854
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.15768339
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.15152667
90SPI1_23127762_ChIP-Seq_K562_Human1.14972100
91* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14638057
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14284947
93* RARB_27405468_Chip-Seq_BRAIN_Mouse1.13231953
94* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12366019
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12097180
96* MAF_26560356_Chip-Seq_TH2_Human1.11135811
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11101785
98E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11017532
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.10401056
100* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09797531
101SCL_19346495_ChIP-Seq_HPC-7_Human1.08880708
102TP53_20018659_ChIP-ChIP_R1E_Mouse1.06999855
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06555803
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06223266
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.06045495
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.05881246
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.05379297
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04946320
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04937568
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04631914
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02843933
112STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02842831
113EZH2_22144423_ChIP-Seq_EOC_Human1.02809721
114TP63_22573176_ChIP-Seq_HFKS_Human1.02659850
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00368676
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99714973
117SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99561747
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99413511
119MYB_26560356_Chip-Seq_TH1_Human0.99202268
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98797420
121POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98349435
122JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98280611
123OCT4_19829295_ChIP-Seq_ESCs_Human0.98083119
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97968068
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97535212
126* NCOR1_26117541_ChIP-Seq_K562_Human0.97509631
127RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96954791
128EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96954791
129EZH2_27294783_Chip-Seq_ESCs_Mouse0.96035103
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95397820
131BRD4_25478319_ChIP-Seq_HGPS_Human0.94699244
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93978772
133MYB_26560356_Chip-Seq_TH2_Human0.92929383
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92561456
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.92364377
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92293695
137RACK7_27058665_Chip-Seq_MCF-7_Human0.91937923
138E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91837662
139CREB1_26743006_Chip-Seq_LNCaP_Human0.91768267
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91126383
141STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90661166
142TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89822954
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89522461
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89333031
145SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89333031
146CIITA_25753668_ChIP-Seq_RAJI_Human0.88702943
147VDR_24763502_ChIP-Seq_THP-1_Human0.88611124
148PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88359961
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.87745192
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87215661
151TBX20_22328084_ChIP-Seq_HEART_Mouse0.86611351
152TBX20_22080862_ChIP-Seq_HEART_Mouse0.86611351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.02506601
2MP0000569_abnormal_digit_pigmentation2.98377129
3MP0003705_abnormal_hypodermis_morpholog2.78418234
4MP0010352_gastrointestinal_tract_polyps2.68243386
5MP0003787_abnormal_imprinting2.59483863
6MP0000566_synostosis2.45923651
7MP0001348_abnormal_lacrimal_gland2.34489678
8MP0005623_abnormal_meninges_morphology2.31566507
9MP0010234_abnormal_vibrissa_follicle2.17811192
10MP0004858_abnormal_nervous_system2.05936681
11MP0002089_abnormal_postnatal_growth/wei1.96125356
12MP0003566_abnormal_cell_adhesion1.94758642
13MP0010030_abnormal_orbit_morphology1.93640610
14MP0003172_abnormal_lysosome_physiology1.89230066
15MP0009278_abnormal_bone_marrow1.86655035
16MP0000678_abnormal_parathyroid_gland1.82351048
17MP0000733_abnormal_muscle_development1.81053912
18MP0005503_abnormal_tendon_morphology1.75735900
19MP0003942_abnormal_urinary_system1.75459837
20MP0008961_abnormal_basal_metabolism1.74778712
21MP0003045_fibrosis1.72943674
22MP0005257_abnormal_intraocular_pressure1.67428181
23MP0008057_abnormal_DNA_replication1.67339587
24MP0003300_gastrointestinal_ulcer1.66640606
25MP0004808_abnormal_hematopoietic_stem1.60975889
26MP0004197_abnormal_fetal_growth/weight/1.58291780
27MP0008438_abnormal_cutaneous_collagen1.57327274
28MP0003941_abnormal_skin_development1.55090644
29MP0010307_abnormal_tumor_latency1.54343267
30MP0003091_abnormal_cell_migration1.53917961
31MP0000579_abnormal_nail_morphology1.53294380
32MP0000778_abnormal_nervous_system1.51669922
33MP0003121_genomic_imprinting1.44402165
34MP0003111_abnormal_nucleus_morphology1.41542263
35MP0004185_abnormal_adipocyte_glucose1.39809216
36* MP0002084_abnormal_developmental_patter1.39239605
37MP0001849_ear_inflammation1.37587477
38MP0010678_abnormal_skin_adnexa1.35066646
39MP0002396_abnormal_hematopoietic_system1.34142874
40MP0002925_abnormal_cardiovascular_devel1.33690449
41MP0001958_emphysema1.30335821
42MP0000703_abnormal_thymus_morphology1.29660445
43MP0002166_altered_tumor_susceptibility1.28414031
44MP0004510_myositis1.27090361
45MP0000537_abnormal_urethra_morphology1.26279496
46MP0004859_abnormal_synaptic_plasticity1.24587067
47MP0002086_abnormal_extraembryonic_tissu1.24414687
48MP0003385_abnormal_body_wall1.24201993
49MP0003283_abnormal_digestive_organ1.23340995
50MP0001672_abnormal_embryogenesis/_devel1.23250326
51MP0005380_embryogenesis_phenotype1.23250326
52MP0000383_abnormal_hair_follicle1.23243347
53MP0003935_abnormal_craniofacial_develop1.22421028
54MP0003763_abnormal_thymus_physiology1.21242850
55MP0010630_abnormal_cardiac_muscle1.19812882
56MP0003984_embryonic_growth_retardation1.19391560
57MP0009703_decreased_birth_body1.18923774
58MP0000534_abnormal_ureter_morphology1.18728324
59MP0002088_abnormal_embryonic_growth/wei1.18559554
60MP0000350_abnormal_cell_proliferation1.18521355
61MP0000428_abnormal_craniofacial_morphol1.18339000
62MP0005023_abnormal_wound_healing1.18096714
63MP0002085_abnormal_embryonic_tissue1.17967533
64MP0001730_embryonic_growth_arrest1.17543221
65MP0001299_abnormal_eye_distance/1.17485858
66MP0002932_abnormal_joint_morphology1.14517618
67MP0003303_peritoneal_inflammation1.13176296
68MP0003828_pulmonary_edema1.11970782
69MP0009053_abnormal_anal_canal1.11799159
70MP0008877_abnormal_DNA_methylation1.11525547
71MP0003115_abnormal_respiratory_system1.11378308
72MP0003567_abnormal_fetal_cardiomyocyte1.09285630
73MP0000003_abnormal_adipose_tissue1.07768827
74* MP0000432_abnormal_head_morphology1.07048006
75MP0002006_tumorigenesis1.06506974
76MP0003077_abnormal_cell_cycle1.06322144
77MP0001784_abnormal_fluid_regulation1.04204556
78MP0010094_abnormal_chromosome_stability1.02851134
79MP0002009_preneoplasia1.01864809
80MP0002877_abnormal_melanocyte_morpholog1.01509513
81MP0004381_abnormal_hair_follicle0.97222285
82MP0002081_perinatal_lethality0.96884615
83MP0003279_aneurysm0.96615185
84MP0002796_impaired_skin_barrier0.95487110
85* MP0002114_abnormal_axial_skeleton0.94797926
86MP0005670_abnormal_white_adipose0.94374292
87MP0005508_abnormal_skeleton_morphology0.94320027
88MP0005501_abnormal_skin_physiology0.93814010
89MP0003890_abnormal_embryonic-extraembry0.93566958
90MP0003453_abnormal_keratinocyte_physiol0.93182534
91MP0000266_abnormal_heart_morphology0.92892971
92MP0002108_abnormal_muscle_morphology0.91814377
93MP0002697_abnormal_eye_size0.90216250
94MP0005375_adipose_tissue_phenotype0.89992727
95MP0009384_cardiac_valve_regurgitation0.89689799
96MP0000049_abnormal_middle_ear0.89380835
97MP0005666_abnormal_adipose_tissue0.89214599
98MP0004233_abnormal_muscle_weight0.88095367
99* MP0001697_abnormal_embryo_size0.88021935
100MP0004087_abnormal_muscle_fiber0.87951933
101MP0002152_abnormal_brain_morphology0.87474473
102MP0008770_decreased_survivor_rate0.87153275
103MP0000762_abnormal_tongue_morphology0.86686803
104MP0003938_abnormal_ear_development0.85577247
105MP0003861_abnormal_nervous_system0.85193917
106MP0003119_abnormal_digestive_system0.85121026
107MP0009379_abnormal_foot_pigmentation0.84358165
108MP0005621_abnormal_cell_physiology0.83410465
109MP0001293_anophthalmia0.82937764
110MP0003937_abnormal_limbs/digits/tail_de0.82673080
111MP0009672_abnormal_birth_weight0.82563408
112MP0002970_abnormal_white_adipose0.82332385
113MP0005451_abnormal_body_composition0.81145305
114MP0002092_abnormal_eye_morphology0.81000772
115MP0000516_abnormal_urinary_system0.80725118
116MP0005367_renal/urinary_system_phenotyp0.80725118
117MP0003755_abnormal_palate_morphology0.80331380
118MP0005248_abnormal_Harderian_gland0.79909167
119MP0010368_abnormal_lymphatic_system0.78896269
120MP0003948_abnormal_gas_homeostasis0.78714290
121MP0001502_abnormal_circadian_rhythm0.77923376
122MP0000751_myopathy0.77881854
123MP0001340_abnormal_eyelid_morphology0.77712803
124MP0002098_abnormal_vibrissa_morphology0.77223500
125MP0000955_abnormal_spinal_cord0.76775517
126MP0002060_abnormal_skin_morphology0.75713131
127MP0009250_abnormal_appendicular_skeleto0.75348179
128MP0000767_abnormal_smooth_muscle0.74501387
129MP0004272_abnormal_basement_membrane0.74280448
130MP0001915_intracranial_hemorrhage0.74181009
131* MP0002116_abnormal_craniofacial_bone0.74141177
132MP0000467_abnormal_esophagus_morphology0.73929438
133* MP0002080_prenatal_lethality0.73441293
134MP0002398_abnormal_bone_marrow0.72864168
135MP0002128_abnormal_blood_circulation0.72620692
136MP0002234_abnormal_pharynx_morphology0.72579506
137MP0002249_abnormal_larynx_morphology0.72164663
138MP0005409_darkened_coat_color0.72030542
139MP0004947_skin_inflammation0.71966654
140MP0003448_altered_tumor_morphology0.71489927
141MP0003122_maternal_imprinting0.70733430
142MP0003123_paternal_imprinting0.70248940
143MP0004957_abnormal_blastocyst_morpholog0.70113573
144MP0004145_abnormal_muscle_electrophysio0.69799234

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.32427649
2Broad face (HP:0000283)3.45818275
3Abnormality of the fingertips (HP:0001211)3.29412424
4Protrusio acetabuli (HP:0003179)3.13398209
5Bronchomalacia (HP:0002780)2.95861265
6Hyperacusis (HP:0010780)2.83432271
7Shallow orbits (HP:0000586)2.81540739
8Urethral obstruction (HP:0000796)2.79449972
9Volvulus (HP:0002580)2.76920404
10Disproportionate tall stature (HP:0001519)2.72134698
11Macroorchidism (HP:0000053)2.65961057
12Long eyelashes (HP:0000527)2.62817347
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59167799
14Short 4th metacarpal (HP:0010044)2.59167799
15Upper limb amyotrophy (HP:0009129)2.58176388
16Distal upper limb amyotrophy (HP:0007149)2.58176388
17Abnormality of the aortic arch (HP:0012303)2.49539551
18Cerebral aneurysm (HP:0004944)2.46838944
19Fragile skin (HP:0001030)2.43538243
20Trigonocephaly (HP:0000243)2.42357236
21Thin bony cortex (HP:0002753)2.39242418
22Deep palmar crease (HP:0006191)2.38874691
23Absent frontal sinuses (HP:0002688)2.32184399
24Mitral regurgitation (HP:0001653)2.30816510
25Sleep apnea (HP:0010535)2.22580825
26Anal stenosis (HP:0002025)2.22053133
27Cervical subluxation (HP:0003308)2.20960532
28Premature rupture of membranes (HP:0001788)2.19552431
29Narrow palate (HP:0000189)2.18303554
30Abnormality of the nasal septum (HP:0000419)2.16688848
31Increased nuchal translucency (HP:0010880)2.15110246
32Ependymoma (HP:0002888)2.14310035
33Patellar dislocation (HP:0002999)2.12221598
34Overgrowth (HP:0001548)2.11274055
35Astrocytoma (HP:0009592)2.10452643
36Abnormality of the astrocytes (HP:0100707)2.10452643
37Biconcave vertebral bodies (HP:0004586)2.08168814
38Distal lower limb amyotrophy (HP:0008944)2.07078195
39Precocious puberty (HP:0000826)2.05691453
40Turricephaly (HP:0000262)2.05662223
41Heterotopia (HP:0002282)2.05568325
42Obsessive-compulsive behavior (HP:0000722)2.05180509
43Elfin facies (HP:0004428)2.02622711
44Subacute progressive viral hepatitis (HP:0006572)2.01260593
45Skull defect (HP:0001362)1.98742141
46Renal duplication (HP:0000075)1.96756666
47Broad thumb (HP:0011304)1.95103890
48Bowel diverticulosis (HP:0005222)1.94463214
49Hand muscle atrophy (HP:0009130)1.94421565
50Lower limb amyotrophy (HP:0007210)1.94080240
51Renovascular hypertension (HP:0100817)1.93480866
52Shawl scrotum (HP:0000049)1.92404213
53Neoplasm of the oral cavity (HP:0100649)1.92101608
54Gastrointestinal carcinoma (HP:0002672)1.91900454
55Malignant gastrointestinal tract tumors (HP:0006749)1.91900454
56Hypoplastic ischia (HP:0003175)1.90182566
57Broad metatarsal (HP:0001783)1.88897396
58Tracheomalacia (HP:0002779)1.88700484
59Neonatal short-limb short stature (HP:0008921)1.88662609
60Lip pit (HP:0100267)1.88343202
61Laryngomalacia (HP:0001601)1.88083209
62Spinal cord lesions (HP:0100561)1.87069645
63Syringomyelia (HP:0003396)1.87069645
64Flat cornea (HP:0007720)1.86966965
65Abnormality of the 4th metacarpal (HP:0010012)1.85339687
66Thin ribs (HP:0000883)1.85155758
67Advanced eruption of teeth (HP:0006288)1.84089600
68Asymmetry of the thorax (HP:0001555)1.83766935
69Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83404668
70Premature skin wrinkling (HP:0100678)1.82236363
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79953376
72Overriding aorta (HP:0002623)1.79151562
73Joint laxity (HP:0001388)1.78730907
74Broad palm (HP:0001169)1.78288958
75Broad finger (HP:0001500)1.77968213
76Aneurysm (HP:0002617)1.76813423
77Limited elbow extension (HP:0001377)1.76214191
78Flat acetabular roof (HP:0003180)1.75687627
79Leiomyosarcoma (HP:0100243)1.75513501
80Uterine leiomyosarcoma (HP:0002891)1.75513501
81Sparse scalp hair (HP:0002209)1.75184027
82Transitional cell carcinoma of the bladder (HP:0006740)1.75178719
83Annular pancreas (HP:0001734)1.74373260
84Aqueductal stenosis (HP:0002410)1.73686162
85Wide anterior fontanel (HP:0000260)1.73150529
86Milia (HP:0001056)1.72639547
87Dislocated radial head (HP:0003083)1.72246353
88* Supernumerary ribs (HP:0005815)1.71178798
89Basal cell carcinoma (HP:0002671)1.70313587
90Bladder diverticulum (HP:0000015)1.69869417
91Bowed forearm bones (HP:0003956)1.69055082
92Bowing of the arm (HP:0006488)1.69055082
93Morphological abnormality of the middle ear (HP:0008609)1.68527300
94Atelectasis (HP:0100750)1.68038625
95* Pointed chin (HP:0000307)1.68024223
96Mitral valve prolapse (HP:0001634)1.67378549
97Ectopic kidney (HP:0000086)1.67259954
98Natal tooth (HP:0000695)1.66569346
99Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65897436
100Short 1st metacarpal (HP:0010034)1.65897436
101Abnormality of the distal phalanx of the thumb (HP:0009617)1.65880324
102Long foot (HP:0001833)1.65705529
103Abnormal vertebral ossification (HP:0100569)1.65424273
104Hypoplasia of the maxilla (HP:0000327)1.65205792
105Blue sclerae (HP:0000592)1.65083489
106Achilles tendon contracture (HP:0001771)1.64777171
107Increased density of long bones (HP:0006392)1.64209948
108Glioma (HP:0009733)1.64042180
109Bladder carcinoma (HP:0002862)1.63764742
110Bladder neoplasm (HP:0009725)1.63764742
111Medulloblastoma (HP:0002885)1.63726540
112Abnormality of the phalanges of the hallux (HP:0010057)1.62831079
113High anterior hairline (HP:0009890)1.62404062
114Short phalanx of the thumb (HP:0009660)1.61696073
115Spinal rigidity (HP:0003306)1.61473308
116Abnormality of dentin (HP:0010299)1.61410852
117Abnormality of the radial head (HP:0003995)1.60208966
118Germ cell neoplasia (HP:0100728)1.59879857
119Aplasia cutis congenita (HP:0001057)1.59802790
120Abnormality of the parietal bone (HP:0002696)1.59685809
121Intestinal fistula (HP:0100819)1.59656021
122Broad long bones (HP:0005622)1.59563935
123Prominent nose (HP:0000448)1.59431485
124Spina bifida occulta (HP:0003298)1.59066290
125Hyperthyroidism (HP:0000836)1.58252932
126Genetic anticipation (HP:0003743)1.58096229
127Hypoventilation (HP:0002791)1.57369814
128Sandal gap (HP:0001852)1.57354083
129Insomnia (HP:0100785)1.56844037
130Abnormality of the columella (HP:0009929)1.55990979
131Attention deficit hyperactivity disorder (HP:0007018)1.55928057
132Ulnar bowing (HP:0003031)1.55404764
133Broad phalanx (HP:0006009)1.54755203
134Smooth philtrum (HP:0000319)1.53942297
135Truncal obesity (HP:0001956)1.53462174
136Abnormality of the diencephalon (HP:0010662)1.53032745
137Broad phalanges of the hand (HP:0009768)1.53003463
138Depressed nasal tip (HP:0000437)1.52636845
139Ankyloglossia (HP:0010296)1.52622256
140Abnormality of oral frenula (HP:0000190)1.52230972
141Pseudobulbar signs (HP:0002200)1.51815988
142Arnold-Chiari malformation (HP:0002308)1.50962329
143Rectal prolapse (HP:0002035)1.50942943
144Abnormality of the ischium (HP:0003174)1.50574948
145Hematochezia (HP:0002573)1.49451871
146Genu recurvatum (HP:0002816)1.49406970
147Dysmetric saccades (HP:0000641)1.48546753
148Atrophic scars (HP:0001075)1.48361621
149Cutis marmorata (HP:0000965)1.48082638
150Deep philtrum (HP:0002002)1.47556242
151Sparse lateral eyebrow (HP:0005338)1.47120115
152Abnormality of the antihelix (HP:0009738)1.46728103
153Increased connective tissue (HP:0009025)1.46223171
154Persistence of primary teeth (HP:0006335)1.45719505
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.45218276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.26142202
2BRD43.10934072
3MAP3K102.74204113
4CAMK1G2.57311476
5PRPF4B2.46329705
6SIK22.43525232
7SMG12.42658379
8EEF2K2.24125586
9RIPK12.22420341
10DMPK2.06299066
11CAMK1D2.03656881
12TTN2.00098175
13MST1R1.84124272
14PNCK1.80660693
15ALK1.76509075
16CDC71.66560673
17PDGFRA1.63539900
18TYRO31.60827302
19MAP4K11.56356683
20TRIB31.52977791
21PKN21.52872712
22MTOR1.50542634
23ICK1.49226480
24PTK61.39843465
25STK101.38857458
26ERN11.37685599
27TAOK11.33722610
28PDGFRB1.32047222
29NTRK11.29902746
30BMX1.27025893
31LATS11.24474194
32CDK61.22506409
33MAPK151.20438149
34FGFR31.14857195
35FGFR21.12302629
36NEK21.12219544
37WNK11.03878621
38MAP3K71.01117485
39CDK40.99682513
40MARK20.98513563
41CDC42BPA0.97606294
42MKNK20.97224227
43LATS20.97006772
44HCK0.95451140
45SGK30.95166668
46EPHA20.93711267
47MARK10.93134886
48ITK0.92657872
49CHUK0.92490521
50IRAK30.90173224
51STK110.88405975
52PRKCH0.88095499
53CHEK10.87797286
54DDR20.86012328
55FGFR10.85654576
56CLK10.85312829
57MAP3K130.84387851
58EPHB10.79977849
59PRKD30.79482027
60RPS6KL10.79241232
61RPS6KC10.79241232
62STK40.78937297
63MET0.78291645
64CSNK1D0.76461571
65PAK20.76264254
66JAK10.75519600
67ATM0.75010391
68EPHB20.74060184
69CDK90.73791041
70MAP3K60.73362375
71PRKD20.73254007
72PTK20.70833575
73SIK10.70110682
74MARK30.69372126
75ATR0.69118749
76GRK60.68553929
77CDK20.68078543
78RIPK40.67355462
79CAMKK10.66488721
80WNK40.65673544
81RPS6KA60.65530982
82TNK20.64227625
83TTK0.64100528
84CAMK40.63022920
85PRKDC0.62497176
86MAPK140.61233334
87CSNK1E0.60786937
88MKNK10.60167080
89MAP3K90.59687083
90SGK4940.59067244
91SGK2230.59067244
92MAPK100.58233029
93MELK0.57848005
94MAPK80.57782502
95GSK3B0.57316719
96CSK0.57176110
97PRKD10.56525637
98SGK10.56075162
99PIM10.55082863
100STK380.54597953
101NME10.54218621
102PDPK10.53436347
103STK30.52990027
104CSNK1A1L0.52922192
105NTRK30.52170779
106CDK70.50568493
107MAPK10.50533994
108TNIK0.49745641
109CDK10.49705113
110SGK20.49003355
111RPS6KB20.48440430
112FES0.47370525
113MAP3K80.46419899
114LCK0.46284106
115AKT10.45322714
116IRAK20.45122349
117HIPK20.44851487
118RET0.44569627
119CAMK10.44415403
120LRRK20.44346569
121LMTK20.42592664
122PAK60.42566253
123PRKAA10.42535278
124MAP3K10.42126093
125RPS6KA10.41432087
126FGFR40.40984443
127RPS6KA30.39867435
128INSR0.39798694
129NTRK20.39476978
130RPS6KA20.39050207
131ERBB20.38054700
132TAOK20.34098552
133MAP2K20.33473256
134MAP2K30.33472241

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045201.55810485
2MicroRNAs in cancer_Homo sapiens_hsa052061.49529434
3Chronic myeloid leukemia_Homo sapiens_hsa052201.47761642
4Lysine degradation_Homo sapiens_hsa003101.47309016
5Thyroid cancer_Homo sapiens_hsa052161.41487276
6B cell receptor signaling pathway_Homo sapiens_hsa046621.34886953
7T cell receptor signaling pathway_Homo sapiens_hsa046601.34002337
8Notch signaling pathway_Homo sapiens_hsa043301.31369111
9Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30766897
10Glioma_Homo sapiens_hsa052141.29558988
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29200624
12Proteoglycans in cancer_Homo sapiens_hsa052051.28615227
13Primary immunodeficiency_Homo sapiens_hsa053401.25923786
14Dorso-ventral axis formation_Homo sapiens_hsa043201.25165738
15mTOR signaling pathway_Homo sapiens_hsa041501.24068275
16Basal cell carcinoma_Homo sapiens_hsa052171.23049926
17Focal adhesion_Homo sapiens_hsa045101.21348233
18Non-small cell lung cancer_Homo sapiens_hsa052231.21247452
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19355402
20Viral myocarditis_Homo sapiens_hsa054161.19009213
21Small cell lung cancer_Homo sapiens_hsa052221.17405997
22Long-term potentiation_Homo sapiens_hsa047201.15700691
23Type II diabetes mellitus_Homo sapiens_hsa049301.15255147
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.14008022
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13199722
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12699626
27Insulin signaling pathway_Homo sapiens_hsa049101.12480987
28mRNA surveillance pathway_Homo sapiens_hsa030151.12464742
29Endometrial cancer_Homo sapiens_hsa052131.11172479
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.09572607
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08823905
32Dilated cardiomyopathy_Homo sapiens_hsa054141.08095275
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07885375
34Estrogen signaling pathway_Homo sapiens_hsa049151.07761387
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07548732
36Colorectal cancer_Homo sapiens_hsa052101.07202597
37Prolactin signaling pathway_Homo sapiens_hsa049171.06160801
38Prostate cancer_Homo sapiens_hsa052151.05769549
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05266619
40Wnt signaling pathway_Homo sapiens_hsa043101.05182247
41HTLV-I infection_Homo sapiens_hsa051661.05137549
42Osteoclast differentiation_Homo sapiens_hsa043801.04819535
43Hippo signaling pathway_Homo sapiens_hsa043901.04447121
44ErbB signaling pathway_Homo sapiens_hsa040121.03675883
45ECM-receptor interaction_Homo sapiens_hsa045121.01265591
46Acute myeloid leukemia_Homo sapiens_hsa052211.00520394
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00435753
48Rap1 signaling pathway_Homo sapiens_hsa040151.00413763
49Pancreatic cancer_Homo sapiens_hsa052120.99653966
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98418930
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98376825
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98257296
53Platelet activation_Homo sapiens_hsa046110.96738752
54MAPK signaling pathway_Homo sapiens_hsa040100.95941888
55Axon guidance_Homo sapiens_hsa043600.95090371
56Renal cell carcinoma_Homo sapiens_hsa052110.94162507
57Pathways in cancer_Homo sapiens_hsa052000.92435644
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92330050
59Melanogenesis_Homo sapiens_hsa049160.92325933
60AMPK signaling pathway_Homo sapiens_hsa041520.91764517
61Oxytocin signaling pathway_Homo sapiens_hsa049210.91070886
62Tight junction_Homo sapiens_hsa045300.90947240
63VEGF signaling pathway_Homo sapiens_hsa043700.90672695
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90250579
65GnRH signaling pathway_Homo sapiens_hsa049120.89804097
66Hedgehog signaling pathway_Homo sapiens_hsa043400.89764177
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89493323
68Gastric acid secretion_Homo sapiens_hsa049710.89215809
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.88345273
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.88162963
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87776333
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87227079
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87066373
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86126345
75Chemokine signaling pathway_Homo sapiens_hsa040620.86016733
76Prion diseases_Homo sapiens_hsa050200.83981864
77Choline metabolism in cancer_Homo sapiens_hsa052310.83112160
78Toxoplasmosis_Homo sapiens_hsa051450.82571501
79Renin secretion_Homo sapiens_hsa049240.81431094
80Salivary secretion_Homo sapiens_hsa049700.80195267
81cAMP signaling pathway_Homo sapiens_hsa040240.79521343
82Cholinergic synapse_Homo sapiens_hsa047250.78061484
83FoxO signaling pathway_Homo sapiens_hsa040680.77795904
84TGF-beta signaling pathway_Homo sapiens_hsa043500.76718363
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76303859
86Circadian entrainment_Homo sapiens_hsa047130.76215457
87Amoebiasis_Homo sapiens_hsa051460.75997977
88Hepatitis B_Homo sapiens_hsa051610.75303467
89Melanoma_Homo sapiens_hsa052180.74419275
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73411133
91Insulin resistance_Homo sapiens_hsa049310.73288656
92Olfactory transduction_Homo sapiens_hsa047400.73046575
93Gap junction_Homo sapiens_hsa045400.72995407
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72962230
95Long-term depression_Homo sapiens_hsa047300.72790384
96Thyroid hormone synthesis_Homo sapiens_hsa049180.72473032
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72178294
98TNF signaling pathway_Homo sapiens_hsa046680.71973690
99Viral carcinogenesis_Homo sapiens_hsa052030.71763282
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71470260
101Leishmaniasis_Homo sapiens_hsa051400.70787461
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70528707
103Bladder cancer_Homo sapiens_hsa052190.70015862
104Non-homologous end-joining_Homo sapiens_hsa034500.69736188
105Glucagon signaling pathway_Homo sapiens_hsa049220.69220203
106Other glycan degradation_Homo sapiens_hsa005110.68887869
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67685914
108Endocytosis_Homo sapiens_hsa041440.67620851
109Ras signaling pathway_Homo sapiens_hsa040140.67361993
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67324057
111Inositol phosphate metabolism_Homo sapiens_hsa005620.67141614
112Cocaine addiction_Homo sapiens_hsa050300.67110933
113Amphetamine addiction_Homo sapiens_hsa050310.66993481
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.66379602
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66189685
116Measles_Homo sapiens_hsa051620.65585859
117Insulin secretion_Homo sapiens_hsa049110.65166260
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.63587261
119Hepatitis C_Homo sapiens_hsa051600.62138929
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.60601560
121Glutamatergic synapse_Homo sapiens_hsa047240.57103750
122Dopaminergic synapse_Homo sapiens_hsa047280.56734353

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