ANKRD12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.09795772
2establishment of protein localization to Golgi (GO:0072600)4.64211407
3ionotropic glutamate receptor signaling pathway (GO:0035235)4.55098356
4presynaptic membrane assembly (GO:0097105)4.51817282
5protein localization to synapse (GO:0035418)4.43815831
6vocalization behavior (GO:0071625)4.43381684
7glutamate receptor signaling pathway (GO:0007215)4.33764895
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.27139138
9pyrimidine nucleobase catabolic process (GO:0006208)4.24627466
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.19217628
11regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.18416686
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17867258
13synaptic vesicle exocytosis (GO:0016079)4.07358615
14gamma-aminobutyric acid transport (GO:0015812)4.00891788
15presynaptic membrane organization (GO:0097090)3.97181253
16activated T cell proliferation (GO:0050798)3.83905441
17neuron recognition (GO:0008038)3.80452550
18negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79643677
19neural tube formation (GO:0001841)3.74085347
20behavioral response to nicotine (GO:0035095)3.68977508
21synaptic transmission, glutamatergic (GO:0035249)3.68192202
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65969092
23postsynaptic membrane organization (GO:0001941)3.65892668
24neuron-neuron synaptic transmission (GO:0007270)3.64985754
25regulation of glutamate receptor signaling pathway (GO:1900449)3.62641890
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60988772
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.54964989
28startle response (GO:0001964)3.54877984
29regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.54273262
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53491817
31nucleobase catabolic process (GO:0046113)3.51113507
32regulation of postsynaptic membrane potential (GO:0060078)3.41455204
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40468180
34response to histamine (GO:0034776)3.40329309
35protein localization to Golgi apparatus (GO:0034067)3.37669683
36dendritic spine morphogenesis (GO:0060997)3.36584138
37retinal cone cell development (GO:0046549)3.35789185
38neuronal action potential propagation (GO:0019227)3.35730216
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35320297
40locomotory exploration behavior (GO:0035641)3.30479687
41regulation of synaptic vesicle exocytosis (GO:2000300)3.30106634
42adaptation of signaling pathway (GO:0023058)3.30027835
43transmission of nerve impulse (GO:0019226)3.18888758
44regulation of rhodopsin mediated signaling pathway (GO:0022400)3.18595901
45negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18127042
46cerebellar Purkinje cell differentiation (GO:0021702)3.15068547
47axonal fasciculation (GO:0007413)3.13248929
48rhodopsin mediated signaling pathway (GO:0016056)3.10952461
49glutamate secretion (GO:0014047)3.09752282
50righting reflex (GO:0060013)3.08370717
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06465672
52neurotransmitter-gated ion channel clustering (GO:0072578)3.06445041
53synaptic vesicle endocytosis (GO:0048488)3.05659765
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.02392775
55long-term memory (GO:0007616)3.02319664
56neuronal action potential (GO:0019228)3.01235181
57membrane hyperpolarization (GO:0060081)3.01220541
58exploration behavior (GO:0035640)2.99755756
59long-term synaptic potentiation (GO:0060291)2.98351429
60positive regulation of synapse assembly (GO:0051965)2.98154755
61regulation of respiratory system process (GO:0044065)2.97261586
62protein localization to cilium (GO:0061512)2.95654593
63positive regulation of membrane potential (GO:0045838)2.95538046
64synapse assembly (GO:0007416)2.94989449
65regulation of synaptic vesicle transport (GO:1902803)2.94889525
66histone H3-K4 trimethylation (GO:0080182)2.88623805
67eye photoreceptor cell development (GO:0042462)2.86788889
68regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86010844
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85715165
70membrane depolarization (GO:0051899)2.84844066
71regulation of vesicle fusion (GO:0031338)2.84199877
72photoreceptor cell development (GO:0042461)2.81653968
73cerebral cortex radially oriented cell migration (GO:0021799)2.80666872
74neurotransmitter secretion (GO:0007269)2.80661508
75detection of calcium ion (GO:0005513)2.79192244
76regulation of voltage-gated calcium channel activity (GO:1901385)2.77862365
77photoreceptor cell maintenance (GO:0045494)2.77481240
78detection of light stimulus involved in visual perception (GO:0050908)2.77162147
79detection of light stimulus involved in sensory perception (GO:0050962)2.77162147
80protein targeting to Golgi (GO:0000042)2.76842236
81behavioral response to cocaine (GO:0048148)2.76270862
82innervation (GO:0060384)2.76129038
83regulation of telomere maintenance (GO:0032204)2.74290178
84fear response (GO:0042596)2.74241691
85cellular potassium ion homeostasis (GO:0030007)2.73117024
86L-fucose catabolic process (GO:0042355)2.71548738
87fucose catabolic process (GO:0019317)2.71548738
88L-fucose metabolic process (GO:0042354)2.71548738
89cerebellar granule cell differentiation (GO:0021707)2.70824671
90behavioral defense response (GO:0002209)2.70795773
91behavioral fear response (GO:0001662)2.70795773
92regulation of neuronal synaptic plasticity (GO:0048168)2.69818815
93retinal rod cell development (GO:0046548)2.69269000
94negative regulation of neurotransmitter transport (GO:0051589)2.69074782
95dendrite development (GO:0016358)2.67542150
96regulation of respiratory gaseous exchange (GO:0043576)2.67484691
97neurotransmitter transport (GO:0006836)2.66895747
98positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.66673084
99regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.66673084
100glycosphingolipid biosynthetic process (GO:0006688)2.64396901
101retina layer formation (GO:0010842)2.62940796
102regulation of synapse assembly (GO:0051963)2.62366826
103learning (GO:0007612)2.62364343
104regulation of neurotransmitter secretion (GO:0046928)2.61889096
105regulation of synaptic transmission, GABAergic (GO:0032228)2.61692673
106serotonin metabolic process (GO:0042428)2.60634496
107dendrite morphogenesis (GO:0048813)2.60328094
108synaptic vesicle maturation (GO:0016188)2.58406921
109mating behavior (GO:0007617)2.54903519
110monoubiquitinated protein deubiquitination (GO:0035520)2.54639901
111mechanosensory behavior (GO:0007638)2.54292191
112positive regulation of potassium ion transmembrane transport (GO:1901381)2.53886947
113regulation of dendritic spine morphogenesis (GO:0061001)2.52434531
114positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.52069641
115positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52020907
116regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52020907
117striatum development (GO:0021756)2.51704567
118establishment of mitochondrion localization (GO:0051654)2.51277392
119intra-Golgi vesicle-mediated transport (GO:0006891)2.51268959
120behavioral response to ethanol (GO:0048149)2.51249388
121membrane depolarization during action potential (GO:0086010)2.50105864
122neuron remodeling (GO:0016322)2.49594729
123epithelial cilium movement (GO:0003351)2.49517822
124regulation of dendritic spine development (GO:0060998)2.49312701
125retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49206277
126nonmotile primary cilium assembly (GO:0035058)2.48788120
127regulation of synaptic plasticity (GO:0048167)2.48044539
128protein K11-linked deubiquitination (GO:0035871)2.47816087
129synapse organization (GO:0050808)2.46815452
130positive regulation of dendritic spine development (GO:0060999)2.46550809
131primary amino compound metabolic process (GO:1901160)2.45476272
132central nervous system projection neuron axonogenesis (GO:0021952)2.45124648
133cAMP catabolic process (GO:0006198)2.44951442
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44819633
135auditory behavior (GO:0031223)2.44286820
136adult walking behavior (GO:0007628)2.42463049
137axoneme assembly (GO:0035082)2.40720929
138intraciliary transport (GO:0042073)2.37715345
139interkinetic nuclear migration (GO:0022027)2.37585539
140cilium morphogenesis (GO:0060271)2.36105144
141neurofilament cytoskeleton organization (GO:0060052)2.34839497
142negative regulation of translation, ncRNA-mediated (GO:0040033)2.33823021
143regulation of translation, ncRNA-mediated (GO:0045974)2.33823021
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.33823021
145negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.33215212
146peptidyl-lysine trimethylation (GO:0018023)2.32747705
147regulation of action potential (GO:0098900)2.32218833
148regulation of feeding behavior (GO:0060259)2.29958811
149forebrain neuron differentiation (GO:0021879)2.28769039
150regulation of synapse structural plasticity (GO:0051823)2.27232074
151cyclic nucleotide catabolic process (GO:0009214)2.26886162
152negative regulation of mast cell activation (GO:0033004)2.26685315
153histone H3-K9 methylation (GO:0051567)2.26611383
154synaptic transmission, cholinergic (GO:0007271)2.26130195
155positive regulation of mRNA catabolic process (GO:0061014)2.25655780
156action potential (GO:0001508)2.25236539
157cilium organization (GO:0044782)2.24557122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93652838
2GBX2_23144817_ChIP-Seq_PC3_Human4.12959422
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57780195
4TAF15_26573619_Chip-Seq_HEK293_Human2.57415351
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55277306
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44814123
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37014164
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21260888
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17665824
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16328331
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15550333
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.14070940
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08732292
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06593152
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06593152
16AR_21572438_ChIP-Seq_LNCaP_Human2.04992358
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02026392
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01804047
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01204632
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99380614
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99318686
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.97258447
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.95068327
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91775870
25P300_19829295_ChIP-Seq_ESCs_Human1.90876588
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90217602
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89575008
28REST_21632747_ChIP-Seq_MESCs_Mouse1.88856455
29SMAD4_21799915_ChIP-Seq_A2780_Human1.87041311
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86289834
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.83355841
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82872387
33FUS_26573619_Chip-Seq_HEK293_Human1.81368198
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.79935881
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75544010
36DROSHA_22980978_ChIP-Seq_HELA_Human1.73732078
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.73505225
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72394859
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.71377890
40VDR_22108803_ChIP-Seq_LS180_Human1.70006936
41IGF1R_20145208_ChIP-Seq_DFB_Human1.62590077
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62243674
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.60798742
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.58424425
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54230562
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54188206
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52080973
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.50293079
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.49277935
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48334075
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48318065
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46310548
53ER_23166858_ChIP-Seq_MCF-7_Human1.46148534
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44131192
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43709722
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43632260
57CBP_20019798_ChIP-Seq_JUKART_Human1.43632260
58RNF2_27304074_Chip-Seq_NSC_Mouse1.42304912
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41186775
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40883069
61STAT3_23295773_ChIP-Seq_U87_Human1.40451861
62AR_25329375_ChIP-Seq_VCAP_Human1.37788548
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33800817
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33509001
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33226787
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33008786
67TCF4_23295773_ChIP-Seq_U87_Human1.31755671
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31671236
69ZNF274_21170338_ChIP-Seq_K562_Hela1.29617347
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.28839555
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27902876
72TP53_16413492_ChIP-PET_HCT116_Human1.27690630
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27494682
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27489700
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.27337789
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.25650499
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24038430
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23945166
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23872948
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23872948
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.23088917
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.23031740
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.22767436
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.22650463
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.22289042
86P53_22387025_ChIP-Seq_ESCs_Mouse1.21844036
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21765420
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21338984
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21062764
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20698000
91RUNX2_22187159_ChIP-Seq_PCA_Human1.20523114
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20425167
93TCF4_22108803_ChIP-Seq_LS180_Human1.20399413
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19180026
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18622268
96BCAT_22108803_ChIP-Seq_LS180_Human1.17959261
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17924685
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17895034
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16759873
100EWS_26573619_Chip-Seq_HEK293_Human1.16095695
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15556341
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14714858
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14392723
104* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14374899
105TP53_18474530_ChIP-ChIP_U2OS_Human1.13880309
106AHR_22903824_ChIP-Seq_MCF-7_Human1.13460818
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11759589
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10874045
109RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10740142
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.07950815
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.07856616
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07077570
113KDM2B_26808549_Chip-Seq_REH_Human1.06375452
114TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05287084
115P300_18555785_Chip-Seq_ESCs_Mouse1.05081023
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.04304347
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.04190098
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04011079
119IRF1_19129219_ChIP-ChIP_H3396_Human1.03678597
120* TP53_22573176_ChIP-Seq_HFKS_Human1.03307562
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02822252
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00188172
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.99439255
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98581941
125SMAD4_21741376_ChIP-Seq_EPCs_Human0.97217367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.11234824
2MP0004859_abnormal_synaptic_plasticity3.95478568
3MP0003635_abnormal_synaptic_transmissio3.22666006
4MP0004270_analgesia3.06415541
5MP0005551_abnormal_eye_electrophysiolog2.78460246
6MP0009745_abnormal_behavioral_response2.76413964
7MP0005423_abnormal_somatic_nervous2.72424669
8MP0002063_abnormal_learning/memory/cond2.63740327
9MP0002064_seizures2.57412396
10MP0001968_abnormal_touch/_nociception2.55039438
11MP0001486_abnormal_startle_reflex2.53898462
12MP0002572_abnormal_emotion/affect_behav2.53882774
13MP0001188_hyperpigmentation2.53552267
14MP0009046_muscle_twitch2.50701239
15MP0002272_abnormal_nervous_system2.41061289
16MP0003121_genomic_imprinting2.28395604
17MP0002735_abnormal_chemical_nociception2.27525556
18MP0002734_abnormal_mechanical_nocicepti2.26030613
19MP0001501_abnormal_sleep_pattern2.13185003
20MP0006072_abnormal_retinal_apoptosis2.11806704
21MP0006276_abnormal_autonomic_nervous2.10813474
22MP0002736_abnormal_nociception_after2.09233247
23MP0001440_abnormal_grooming_behavior2.02975025
24MP0002067_abnormal_sensory_capabilities2.00597615
25MP0001984_abnormal_olfaction1.98170254
26MP0000778_abnormal_nervous_system1.97656555
27MP0005409_darkened_coat_color1.82281191
28MP0000569_abnormal_digit_pigmentation1.80255131
29MP0002184_abnormal_innervation1.77733586
30MP0003787_abnormal_imprinting1.77033498
31MP0005253_abnormal_eye_physiology1.70998429
32MP0002557_abnormal_social/conspecific_i1.70790265
33MP0001970_abnormal_pain_threshold1.62868361
34MP0004742_abnormal_vestibular_system1.62801807
35MP0005646_abnormal_pituitary_gland1.62594569
36MP0001502_abnormal_circadian_rhythm1.59608417
37MP0004924_abnormal_behavior1.58613336
38MP0005386_behavior/neurological_phenoty1.58613336
39MP0010386_abnormal_urinary_bladder1.54822364
40MP0002733_abnormal_thermal_nociception1.52444283
41MP0001529_abnormal_vocalization1.52134517
42MP0008569_lethality_at_weaning1.50348723
43MP0002882_abnormal_neuron_morphology1.43685228
44MP0005645_abnormal_hypothalamus_physiol1.43562976
45MP0002822_catalepsy1.40175700
46MP0001905_abnormal_dopamine_level1.39935973
47MP0009780_abnormal_chondrocyte_physiolo1.38869375
48MP0002638_abnormal_pupillary_reflex1.38590532
49MP0000427_abnormal_hair_cycle1.33931150
50MP0004043_abnormal_pH_regulation1.33029431
51MP0002229_neurodegeneration1.27978048
52MP0005671_abnormal_response_to1.26739102
53MP0003195_calcinosis1.25907962
54MP0006292_abnormal_olfactory_placode1.25634030
55MP0002928_abnormal_bile_duct1.23633177
56MP0000955_abnormal_spinal_cord1.20334156
57MP0000015_abnormal_ear_pigmentation1.19405471
58MP0002752_abnormal_somatic_nervous1.19290148
59MP0004142_abnormal_muscle_tone1.18699167
60MP0005171_absent_coat_pigmentation1.16095367
61MP0003183_abnormal_peptide_metabolism1.12970966
62MP0002066_abnormal_motor_capabilities/c1.12892807
63MP0004885_abnormal_endolymph1.11586152
64MP0003879_abnormal_hair_cell1.11199902
65MP0005195_abnormal_posterior_eye1.10587181
66MP0002090_abnormal_vision1.09847281
67MP0001963_abnormal_hearing_physiology1.08401094
68MP0004811_abnormal_neuron_physiology1.06045701
69MP0004145_abnormal_muscle_electrophysio1.04865890
70MP0008877_abnormal_DNA_methylation1.02283173
71MP0002009_preneoplasia1.00088291
72MP0002102_abnormal_ear_morphology0.99365076
73MP0000631_abnormal_neuroendocrine_gland0.98714733
74MP0001986_abnormal_taste_sensitivity0.97595660
75MP0005379_endocrine/exocrine_gland_phen0.96919747
76MP0002277_abnormal_respiratory_mucosa0.93878829
77MP0003136_yellow_coat_color0.91979954
78MP0002876_abnormal_thyroid_physiology0.90135059
79MP0002909_abnormal_adrenal_gland0.90065850
80MP0003890_abnormal_embryonic-extraembry0.89958821
81MP0002152_abnormal_brain_morphology0.88807619
82MP0003634_abnormal_glial_cell0.88162886
83MP0000920_abnormal_myelination0.87487286
84MP0008872_abnormal_physiological_respon0.87153140
85MP0005394_taste/olfaction_phenotype0.86542922
86MP0005499_abnormal_olfactory_system0.86542922
87MP0003122_maternal_imprinting0.85863240
88MP0005174_abnormal_tail_pigmentation0.84560399
89MP0002095_abnormal_skin_pigmentation0.83740488
90MP0000026_abnormal_inner_ear0.83329987
91MP0003724_increased_susceptibility_to0.82491516
92MP0001919_abnormal_reproductive_system0.81464658
93MP0003633_abnormal_nervous_system0.81351425
94MP0005310_abnormal_salivary_gland0.80112701
95MP0005075_abnormal_melanosome_morpholog0.79349728
96MP0004130_abnormal_muscle_cell0.78538665
97MP0002653_abnormal_ependyma_morphology0.77440394
98MP0003011_delayed_dark_adaptation0.77125786
99MP0008995_early_reproductive_senescence0.75839560
100MP0004147_increased_porphyrin_level0.75614457
101MP0003646_muscle_fatigue0.75580387
102MP0001800_abnormal_humoral_immune0.74379075
103MP0001299_abnormal_eye_distance/0.71818041
104MP0003631_nervous_system_phenotype0.71817538
105MP0003632_abnormal_nervous_system0.70794997
106MP0003329_amyloid_beta_deposits0.70485069
107MP0004858_abnormal_nervous_system0.69754706
108MP0001324_abnormal_eye_pigmentation0.68430140
109MP0004510_myositis0.67999738
110MP0004133_heterotaxia0.67789569
111MP0004085_abnormal_heartbeat0.67627439
112MP0001485_abnormal_pinna_reflex0.66487598
113MP0002837_dystrophic_cardiac_calcinosis0.66450541
114MP0002069_abnormal_eating/drinking_beha0.66086976
115MP0005084_abnormal_gallbladder_morpholo0.65527602
116MP0005187_abnormal_penis_morphology0.65079019
117MP0000372_irregular_coat_pigmentation0.64519762
118MP0005389_reproductive_system_phenotype0.64387682
119MP0002163_abnormal_gland_morphology0.58426853
120MP0003938_abnormal_ear_development0.58110170
121MP0008789_abnormal_olfactory_epithelium0.57971140
122MP0005535_abnormal_body_temperature0.57907930
123MP0000013_abnormal_adipose_tissue0.57310753
124MP0005391_vision/eye_phenotype0.57184094
125MP0008874_decreased_physiological_sensi0.56621378
126MP0004215_abnormal_myocardial_fiber0.55815162

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.77150999
2Congenital stationary night blindness (HP:0007642)4.56209209
3Febrile seizures (HP:0002373)4.50586619
4Epileptic encephalopathy (HP:0200134)4.39776854
5Focal seizures (HP:0007359)4.19980428
6Atonic seizures (HP:0010819)3.98823800
7Progressive cerebellar ataxia (HP:0002073)3.72261788
8Hyperventilation (HP:0002883)3.53309312
9Broad-based gait (HP:0002136)3.51690064
10Pancreatic cysts (HP:0001737)3.51671120
11Visual hallucinations (HP:0002367)3.47272354
12Absence seizures (HP:0002121)3.46507397
13Volvulus (HP:0002580)3.38411795
14Abnormality of macular pigmentation (HP:0008002)3.35217915
15Dialeptic seizures (HP:0011146)3.24757485
16Abnormality of the renal cortex (HP:0011035)3.19503180
17Gait imbalance (HP:0002141)3.18167239
18Abnormal rod and cone electroretinograms (HP:0008323)3.11215706
19Bony spicule pigmentary retinopathy (HP:0007737)3.07764682
20Medial flaring of the eyebrow (HP:0010747)3.02903835
21Abnormality of the renal medulla (HP:0100957)3.02412681
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.00460740
23Drooling (HP:0002307)2.97207604
24Excessive salivation (HP:0003781)2.97207604
25Generalized tonic-clonic seizures (HP:0002069)2.84579894
26Absent speech (HP:0001344)2.84178882
27Congenital primary aphakia (HP:0007707)2.80906438
28Gaze-evoked nystagmus (HP:0000640)2.79359461
29Myokymia (HP:0002411)2.79036208
30Dyschromatopsia (HP:0007641)2.77690036
31Central scotoma (HP:0000603)2.75494322
32Renal cortical cysts (HP:0000803)2.71060209
33Decreased central vision (HP:0007663)2.70345109
34Nephrogenic diabetes insipidus (HP:0009806)2.68954370
35Chronic hepatic failure (HP:0100626)2.68489704
36Stomach cancer (HP:0012126)2.67964073
37Abnormal hair whorl (HP:0010721)2.67350412
38Protruding tongue (HP:0010808)2.62892578
39Attenuation of retinal blood vessels (HP:0007843)2.59626060
40Truncal ataxia (HP:0002078)2.56233488
41Widely spaced teeth (HP:0000687)2.54249173
42Lissencephaly (HP:0001339)2.53212690
43Genital tract atresia (HP:0001827)2.37199934
44Amblyopia (HP:0000646)2.35993454
45Action tremor (HP:0002345)2.34052336
46Vaginal atresia (HP:0000148)2.32444248
47Oligodactyly (hands) (HP:0001180)2.29991142
48Pachygyria (HP:0001302)2.28564140
49Absent/shortened dynein arms (HP:0200106)2.28162453
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.28162453
51Retinal dysplasia (HP:0007973)2.28133392
52Polydipsia (HP:0001959)2.27071959
53Abnormal drinking behavior (HP:0030082)2.27071959
54Supranuclear gaze palsy (HP:0000605)2.25216668
55Severe visual impairment (HP:0001141)2.24962781
56Blue irides (HP:0000635)2.20490605
57Epileptiform EEG discharges (HP:0011182)2.18046794
58Progressive inability to walk (HP:0002505)2.17965696
59Poor coordination (HP:0002370)2.16550962
60Increased corneal curvature (HP:0100692)2.16318148
61Keratoconus (HP:0000563)2.16318148
62Scotoma (HP:0000575)2.16148552
63Genetic anticipation (HP:0003743)2.15349838
64Abnormality of salivation (HP:0100755)2.14904309
65Abnormality of binocular vision (HP:0011514)2.14816546
66Diplopia (HP:0000651)2.14816546
67Abnormality of midbrain morphology (HP:0002418)2.13457967
68Molar tooth sign on MRI (HP:0002419)2.13457967
69Cystic liver disease (HP:0006706)2.11893365
70Stomatitis (HP:0010280)2.11876535
71Dysmetria (HP:0001310)2.10150298
72Aplasia/Hypoplasia of the lens (HP:0008063)2.10014962
73Hemiparesis (HP:0001269)2.09096245
74Dysdiadochokinesis (HP:0002075)2.08984062
75EEG with generalized epileptiform discharges (HP:0011198)2.06735727
76Congenital sensorineural hearing impairment (HP:0008527)2.06051193
77Tubular atrophy (HP:0000092)2.04439094
78Exotropia (HP:0000577)1.96338664
79Papilledema (HP:0001085)1.95953869
80Pancreatic fibrosis (HP:0100732)1.95073585
81Generalized hypopigmentation of hair (HP:0011358)1.94436863
82Inability to walk (HP:0002540)1.93620464
83Narrow forehead (HP:0000341)1.93421420
84Tented upper lip vermilion (HP:0010804)1.93326643
85Nephronophthisis (HP:0000090)1.93121368
86Retinitis pigmentosa (HP:0000510)1.92739872
87Abnormal eating behavior (HP:0100738)1.92384441
88Thickened helices (HP:0000391)1.92268680
89Neurofibrillary tangles (HP:0002185)1.90813135
90Abolished electroretinogram (ERG) (HP:0000550)1.90661320
91Hemiplegia (HP:0002301)1.90622555
92Photophobia (HP:0000613)1.90598515
93Choroideremia (HP:0001139)1.88088444
94Dyskinesia (HP:0100660)1.87193407
95Mutism (HP:0002300)1.86890704
96Intellectual disability, severe (HP:0010864)1.86315734
97Hypothermia (HP:0002045)1.86032140
98Inappropriate behavior (HP:0000719)1.85096654
99Thyroiditis (HP:0100646)1.84690255
100Abnormal ciliary motility (HP:0012262)1.84603794
101Decreased circulating renin level (HP:0003351)1.84047815
102Poor eye contact (HP:0000817)1.83690108
103Gastroesophageal reflux (HP:0002020)1.83480680
104Scanning speech (HP:0002168)1.82919362
105Spastic tetraplegia (HP:0002510)1.82914439
106Abnormality of the labia minora (HP:0012880)1.81986514
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81591095
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.81591095
109Postaxial hand polydactyly (HP:0001162)1.81433978
110Optic disc pallor (HP:0000543)1.80938044
111Congenital hepatic fibrosis (HP:0002612)1.80864037
112Short tibia (HP:0005736)1.80449850
113Hip dysplasia (HP:0001385)1.79751751
114Amyotrophic lateral sclerosis (HP:0007354)1.77518950
115Hypsarrhythmia (HP:0002521)1.77244929
116Anxiety (HP:0000739)1.76539190
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.76159867
118Intellectual disability, progressive (HP:0006887)1.76017218
119Short foot (HP:0001773)1.76003517
120Papillary thyroid carcinoma (HP:0002895)1.75902191
121Fair hair (HP:0002286)1.75322580
122Abnormality of the corticospinal tract (HP:0002492)1.75314326
123Specific learning disability (HP:0001328)1.74915677
124Polyphagia (HP:0002591)1.73339664
125Esotropia (HP:0000565)1.73138921
126True hermaphroditism (HP:0010459)1.73077357
127Limb dystonia (HP:0002451)1.70722422
128Cerebral inclusion bodies (HP:0100314)1.70495486
129Agitation (HP:0000713)1.70325070
130Urinary bladder sphincter dysfunction (HP:0002839)1.67278250
131Type II lissencephaly (HP:0007260)1.66785969
132Pendular nystagmus (HP:0012043)1.65774743
133Polyuria (HP:0000103)1.65771213
134Stereotypic behavior (HP:0000733)1.65484404
135Hypochromic microcytic anemia (HP:0004840)1.64770492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.80995796
2NTRK33.36204386
3MARK12.91412372
4MAP3K42.70023758
5MAP2K72.68688777
6TNIK2.61236680
7RIPK42.60414151
8EPHA42.58843918
9PNCK2.46188591
10SIK22.08814979
11MAP4K22.02072851
12PINK11.99301565
13MAP3K121.98240453
14NTRK21.96742704
15MAPK131.94225565
16PLK21.71605382
17ACVR1B1.67064425
18TRIM281.64942275
19BMPR21.55888004
20MAP3K91.55661380
21NUAK11.53463094
22CAMK1G1.49466339
23FES1.45650804
24MINK11.32880204
25INSRR1.24616856
26FGR1.19344325
27CAMK2A1.18228760
28EPHA31.17921827
29GRK51.17593359
30CDK51.15142853
31NME11.13145503
32PKN11.12207097
33MAP3K131.04377280
34SIK31.02891895
35CDK31.00154826
36GRK10.99919324
37MUSK0.99559951
38MAP2K40.99486961
39PRPF4B0.98778983
40PAK60.98467927
41OXSR10.97692764
42DYRK1A0.96411779
43TEC0.95883287
44AKT30.95792696
45TAOK30.95767352
46STK390.95143076
47SGK20.94835903
48NLK0.94580952
49GRK70.93851271
50SGK2230.93711264
51SGK4940.93711264
52PIK3CA0.91524665
53CAMKK20.91199414
54CAMK2B0.90425711
55PRKCE0.88566220
56SGK10.88111644
57UHMK10.87717553
58BMPR1B0.87525118
59NTRK10.87112349
60MARK20.85498934
61NEK60.83724580
62TNK20.82665102
63CSNK1G20.81135755
64IKBKE0.79999305
65YES10.79718196
66WNK30.78605887
67DAPK20.76385498
68KSR10.76280862
69WNK10.74605847
70BCR0.74529390
71PRKCG0.74468390
72IRAK20.74183539
73PHKG20.72080467
74PHKG10.72080467
75ADRBK20.71082081
76CSNK1G10.69919810
77STK110.69474256
78CAMK2D0.67849823
79MAPKAPK50.67065537
80TXK0.65658166
81FRK0.64532768
82CAMK1D0.63131152
83PAK30.62882952
84STK160.62026815
85MKNK20.61712311
86CAMK10.61274943
87PRKCZ0.60269402
88MAP3K60.60187791
89CSNK1A1L0.58801900
90TYRO30.58690990
91WNK40.58585853
92PRKG10.57392795
93ITK0.57000698
94PRKCQ0.56203985
95MARK30.55485862
96DAPK10.55264071
97DYRK20.54268285
98HIPK20.53338239
99PTK2B0.53333148
100ADRBK10.53013572
101CHUK0.52343184
102FGFR20.48642104
103FYN0.48619296
104IRAK10.48350791
105MAP4K10.45902943
106CAMK40.45294863
107CSNK1G30.45284022
108ERBB30.45224168
109MAPK100.45177925
110CDK190.45039057
111DMPK0.44971737
112SYK0.44963795
113CAMKK10.44952574
114PRKCB0.44194125
115ROCK20.44056004
116SGK30.44051647
117PRKCH0.43794033
118PRKACA0.42342472
119RAF10.41052447
120CSNK1D0.40334178
121LYN0.39675768
122LCK0.39456832
123ZAK0.39273207
124IKBKB0.38999654
125PRKACB0.38623433
126ERBB20.38046961
127MAP2K60.36427802
128RPS6KA30.36223677
129CSNK1A10.35331605

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69787149
2Phototransduction_Homo sapiens_hsa047443.52409560
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57662122
4Glutamatergic synapse_Homo sapiens_hsa047242.41995834
5Morphine addiction_Homo sapiens_hsa050322.33454382
6GABAergic synapse_Homo sapiens_hsa047272.29474793
7Circadian entrainment_Homo sapiens_hsa047132.24856193
8Synaptic vesicle cycle_Homo sapiens_hsa047212.21821425
9Long-term potentiation_Homo sapiens_hsa047202.15745999
10Olfactory transduction_Homo sapiens_hsa047402.09378769
11Serotonergic synapse_Homo sapiens_hsa047262.06639776
12Amphetamine addiction_Homo sapiens_hsa050311.99630886
13Taste transduction_Homo sapiens_hsa047421.91507802
14Salivary secretion_Homo sapiens_hsa049701.91139350
15Dopaminergic synapse_Homo sapiens_hsa047281.80161445
16Long-term depression_Homo sapiens_hsa047301.77801148
17Insulin secretion_Homo sapiens_hsa049111.77043186
18Renin secretion_Homo sapiens_hsa049241.75973434
19Cholinergic synapse_Homo sapiens_hsa047251.63297941
20Collecting duct acid secretion_Homo sapiens_hsa049661.59846425
21Regulation of autophagy_Homo sapiens_hsa041401.59482707
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55605337
23Cocaine addiction_Homo sapiens_hsa050301.52139106
24Linoleic acid metabolism_Homo sapiens_hsa005911.51936829
25Calcium signaling pathway_Homo sapiens_hsa040201.46485880
26Gastric acid secretion_Homo sapiens_hsa049711.45336372
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45220106
28Protein export_Homo sapiens_hsa030601.44374724
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.43131946
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40439168
31Oxytocin signaling pathway_Homo sapiens_hsa049211.40141166
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35031871
33Butanoate metabolism_Homo sapiens_hsa006501.34640859
34Axon guidance_Homo sapiens_hsa043601.24085445
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20406535
36cAMP signaling pathway_Homo sapiens_hsa040241.18998327
37GnRH signaling pathway_Homo sapiens_hsa049121.18199850
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15729191
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15598591
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15282992
41Nitrogen metabolism_Homo sapiens_hsa009101.14696541
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05782579
43Graft-versus-host disease_Homo sapiens_hsa053321.04944861
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04285340
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03389598
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.02403711
47Vibrio cholerae infection_Homo sapiens_hsa051101.01819253
48Gap junction_Homo sapiens_hsa045401.00971118
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00634282
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99502574
51ErbB signaling pathway_Homo sapiens_hsa040120.97764368
52Cardiac muscle contraction_Homo sapiens_hsa042600.97298805
53Type II diabetes mellitus_Homo sapiens_hsa049300.96201472
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91900190
55Primary immunodeficiency_Homo sapiens_hsa053400.91445271
56Allograft rejection_Homo sapiens_hsa053300.90674141
57Oxidative phosphorylation_Homo sapiens_hsa001900.88820635
58Alzheimers disease_Homo sapiens_hsa050100.88767777
59Pancreatic secretion_Homo sapiens_hsa049720.88354607
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86957771
61Basal transcription factors_Homo sapiens_hsa030220.83299380
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82537252
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.82104102
64Melanogenesis_Homo sapiens_hsa049160.81951729
65Choline metabolism in cancer_Homo sapiens_hsa052310.78792962
66Estrogen signaling pathway_Homo sapiens_hsa049150.78650460
67Dorso-ventral axis formation_Homo sapiens_hsa043200.78273050
68Glioma_Homo sapiens_hsa052140.76743405
69African trypanosomiasis_Homo sapiens_hsa051430.76688662
70MAPK signaling pathway_Homo sapiens_hsa040100.76140770
71Rheumatoid arthritis_Homo sapiens_hsa053230.76029197
72RNA degradation_Homo sapiens_hsa030180.75713073
73Circadian rhythm_Homo sapiens_hsa047100.74767799
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74315084
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73755186
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73235719
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73070803
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72825656
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72789280
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.72735724
81Ras signaling pathway_Homo sapiens_hsa040140.71393443
82Inositol phosphate metabolism_Homo sapiens_hsa005620.69013169
83Dilated cardiomyopathy_Homo sapiens_hsa054140.68680935
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.62936350
85ABC transporters_Homo sapiens_hsa020100.62921840
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60103749
87Sphingolipid metabolism_Homo sapiens_hsa006000.59596120
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57582564
89Ovarian steroidogenesis_Homo sapiens_hsa049130.57516995
90Chemokine signaling pathway_Homo sapiens_hsa040620.57141210
91Type I diabetes mellitus_Homo sapiens_hsa049400.56444793
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56295896
93Thyroid hormone synthesis_Homo sapiens_hsa049180.54224434
94Ether lipid metabolism_Homo sapiens_hsa005650.53823096
95Wnt signaling pathway_Homo sapiens_hsa043100.53687368
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.52867802
97T cell receptor signaling pathway_Homo sapiens_hsa046600.52773951
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52381313
99Caffeine metabolism_Homo sapiens_hsa002320.49282996
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48969708
101Phagosome_Homo sapiens_hsa041450.48341262
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48314376
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47007533
104Autoimmune thyroid disease_Homo sapiens_hsa053200.46903205
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46106667
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45685273
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45415919
108Rap1 signaling pathway_Homo sapiens_hsa040150.44387953
109Renal cell carcinoma_Homo sapiens_hsa052110.44076921
110Alcoholism_Homo sapiens_hsa050340.43553669
111Prolactin signaling pathway_Homo sapiens_hsa049170.43516468
112Asthma_Homo sapiens_hsa053100.41959242
113Tryptophan metabolism_Homo sapiens_hsa003800.41833299
114Parkinsons disease_Homo sapiens_hsa050120.40872740
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.40532274
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39504386
117Huntingtons disease_Homo sapiens_hsa050160.39008627
118FoxO signaling pathway_Homo sapiens_hsa040680.38392238
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36925199
120Peroxisome_Homo sapiens_hsa041460.36826873
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35730992
122Glycerolipid metabolism_Homo sapiens_hsa005610.35655604
123Platelet activation_Homo sapiens_hsa046110.35340211
124Melanoma_Homo sapiens_hsa052180.34706224
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.33615631
126VEGF signaling pathway_Homo sapiens_hsa043700.33060406
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31270845
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31177809
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29466619
130Mineral absorption_Homo sapiens_hsa049780.28789552
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28540844
132Oocyte meiosis_Homo sapiens_hsa041140.27728563

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