ANKRD13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.82678650
2layer formation in cerebral cortex (GO:0021819)5.67622369
3locomotory exploration behavior (GO:0035641)5.53959642
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42000322
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.22826354
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.96102375
7vocalization behavior (GO:0071625)4.91126130
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86419269
9dendritic spine morphogenesis (GO:0060997)4.59351397
10regulation of synapse structural plasticity (GO:0051823)4.56931095
11protein localization to synapse (GO:0035418)4.51984556
12synaptic vesicle exocytosis (GO:0016079)4.47200557
13glutamate secretion (GO:0014047)4.43596815
14neuron cell-cell adhesion (GO:0007158)4.42778066
15regulation of glutamate receptor signaling pathway (GO:1900449)4.39650957
16cell migration in hindbrain (GO:0021535)4.34024750
17exploration behavior (GO:0035640)4.31013648
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.27027964
19regulation of synaptic vesicle exocytosis (GO:2000300)4.22067220
20dendrite morphogenesis (GO:0048813)4.17230092
21neuron recognition (GO:0008038)4.03938015
22regulation of neuronal synaptic plasticity (GO:0048168)3.99409402
23axonal fasciculation (GO:0007413)3.97538626
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.96422930
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.90220843
26proline transport (GO:0015824)3.74056517
27neurotransmitter secretion (GO:0007269)3.68313831
28positive regulation of synapse maturation (GO:0090129)3.66853877
29pyrimidine nucleobase catabolic process (GO:0006208)3.62517757
30regulation of synaptic vesicle transport (GO:1902803)3.62354312
31central nervous system projection neuron axonogenesis (GO:0021952)3.55215090
32regulation of dendritic spine morphogenesis (GO:0061001)3.54976462
33neuromuscular process controlling balance (GO:0050885)3.52749352
34auditory behavior (GO:0031223)3.52223384
35presynaptic membrane assembly (GO:0097105)3.45241011
36negative regulation of microtubule polymerization (GO:0031115)3.45029316
37synaptic transmission, glutamatergic (GO:0035249)3.42969632
38activation of protein kinase A activity (GO:0034199)3.40531904
39postsynaptic membrane organization (GO:0001941)3.39167719
40glutamate receptor signaling pathway (GO:0007215)3.39023901
41gamma-aminobutyric acid transport (GO:0015812)3.36507276
42neuronal action potential propagation (GO:0019227)3.35560309
43presynaptic membrane organization (GO:0097090)3.33240017
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31850210
45clathrin coat assembly (GO:0048268)3.26536606
46neurotransmitter-gated ion channel clustering (GO:0072578)3.26507518
47G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24167893
48establishment of nucleus localization (GO:0040023)3.23332632
49positive regulation of membrane potential (GO:0045838)3.21066753
50mitochondrion transport along microtubule (GO:0047497)3.18670240
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.18670240
52establishment of mitochondrion localization (GO:0051654)3.18454080
53transmission of nerve impulse (GO:0019226)3.17128258
54axon extension (GO:0048675)3.17022302
55cerebellar Purkinje cell layer development (GO:0021680)3.15687805
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15105985
57long-term memory (GO:0007616)3.14535651
58dendritic spine organization (GO:0097061)3.14017631
59sodium ion export (GO:0071436)3.12327329
60neuronal ion channel clustering (GO:0045161)3.11823164
61positive regulation of dendritic spine development (GO:0060999)3.10698613
62prepulse inhibition (GO:0060134)3.09927139
63neuron-neuron synaptic transmission (GO:0007270)3.08974871
64regulation of synaptic plasticity (GO:0048167)3.06113937
65dopamine receptor signaling pathway (GO:0007212)3.06067341
66cell communication by electrical coupling (GO:0010644)3.05650091
67response to auditory stimulus (GO:0010996)3.03779886
68cytoskeletal anchoring at plasma membrane (GO:0007016)3.03502861
69cellular potassium ion homeostasis (GO:0030007)3.01327581
70regulation of dendritic spine development (GO:0060998)3.00266875
71positive regulation of dendritic spine morphogenesis (GO:0061003)3.00088602
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00000403
73cerebellar Purkinje cell differentiation (GO:0021702)2.99979321
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99869293
75organelle transport along microtubule (GO:0072384)2.99788460
76positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99227381
77glycine transport (GO:0015816)2.98354432
78nucleobase catabolic process (GO:0046113)2.97899804
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97669493
80regulation of postsynaptic membrane potential (GO:0060078)2.97339262
81synaptic vesicle endocytosis (GO:0048488)2.94904420
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90591935
83nerve growth factor signaling pathway (GO:0038180)2.89482038
84regulation of neurotransmitter secretion (GO:0046928)2.88804563
85neuron projection extension (GO:1990138)2.88646425
86regulation of synapse maturation (GO:0090128)2.86353924
87neurotransmitter transport (GO:0006836)2.84771421
88protein-DNA complex disassembly (GO:0032986)2.84349891
89nucleosome disassembly (GO:0006337)2.84349891
90negative regulation of axonogenesis (GO:0050771)2.83443270
91cerebellar granule cell differentiation (GO:0021707)2.83081751
92adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.81630326
93vesicle transport along microtubule (GO:0047496)2.81444628
94spinal cord development (GO:0021510)2.80705496
95regulation of ARF protein signal transduction (GO:0032012)2.80496751
96central nervous system neuron axonogenesis (GO:0021955)2.80029117
97synapse assembly (GO:0007416)2.79859302
98synapse organization (GO:0050808)2.78331528
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77898184
100membrane depolarization during action potential (GO:0086010)2.77643322
101regulation of vesicle fusion (GO:0031338)2.76266920
102cranial nerve morphogenesis (GO:0021602)2.75501349
103axon cargo transport (GO:0008088)2.75235430
104positive regulation of axon extension (GO:0045773)2.74141231
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73498823
106neuromuscular process (GO:0050905)2.72879343
107regulation of axon extension (GO:0030516)2.72720727
108neuron projection morphogenesis (GO:0048812)2.71451608
109axon ensheathment in central nervous system (GO:0032291)2.70128315
110central nervous system myelination (GO:0022010)2.70128315
111positive regulation of synapse assembly (GO:0051965)2.62898084
112behavioral response to nicotine (GO:0035095)2.62623275
113regulation of respiratory system process (GO:0044065)2.61929519
114pattern specification involved in kidney development (GO:0061004)2.57356617
115mechanosensory behavior (GO:0007638)2.56358143
116body morphogenesis (GO:0010171)2.54607539
117negative regulation of catenin import into nucleus (GO:0035414)2.48361623
118embryonic body morphogenesis (GO:0010172)2.44528990
119neuromuscular synaptic transmission (GO:0007274)2.43937988
120cell differentiation in hindbrain (GO:0021533)2.42330627
121cerebral cortex radially oriented cell migration (GO:0021799)2.41978127
122cell-cell junction maintenance (GO:0045217)2.41856683
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40226312
124regulation of respiratory gaseous exchange (GO:0043576)2.39915889
125microtubule severing (GO:0051013)2.37292416
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35165928
127acrosome reaction (GO:0007340)2.32785254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77329251
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80546992
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05930961
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94243216
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90975476
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90975476
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89874124
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.88679885
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.83122133
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71365655
11DROSHA_22980978_ChIP-Seq_HELA_Human2.69769882
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.66161398
13REST_21632747_ChIP-Seq_MESCs_Mouse2.54832040
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53074022
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48543710
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.48240532
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45010295
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43150061
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42949638
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37906568
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37626132
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.37457570
23GBX2_23144817_ChIP-Seq_PC3_Human2.27215563
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22553602
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21842644
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.16017360
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.12848027
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01758887
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.97513956
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.91488445
31KDM2B_26808549_Chip-Seq_K562_Human1.90110141
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89268358
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.84642996
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62032477
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.61834974
36AR_21572438_ChIP-Seq_LNCaP_Human1.61797910
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59047391
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56389701
39* RING1B_27294783_Chip-Seq_NPCs_Mouse1.53923334
40* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53133191
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52611354
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49572492
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47968618
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40381604
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.40024017
46P68_20966046_ChIP-Seq_HELA_Human1.38999091
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36852882
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.35683390
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34652559
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32298536
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31986101
52KDM2B_26808549_Chip-Seq_DND41_Human1.29411437
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.28002658
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26925256
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25441405
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25003449
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24277819
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24041974
59LXR_22292898_ChIP-Seq_THP-1_Human1.20295065
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19951596
61ZNF274_21170338_ChIP-Seq_K562_Hela1.18052771
62AR_19668381_ChIP-Seq_PC3_Human1.15713028
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15711690
64CTCF_27219007_Chip-Seq_Bcells_Human1.15442408
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.15396246
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15363828
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.13423298
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13365475
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12148646
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11410571
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10421498
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09481722
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09461635
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09100054
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.07845070
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07798590
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07561535
78* TET1_21490601_ChIP-Seq_MESCs_Mouse1.06883964
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05276900
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04105449
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04024572
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03946066
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.03913942
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03757554
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03102208
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01462887
87ZNF263_19887448_ChIP-Seq_K562_Human1.01233012
88P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99356747
89SA1_27219007_Chip-Seq_ERYTHROID_Human0.98808066
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97456607
91THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97453862
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97387527
93RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96995603
94SMAD4_21799915_ChIP-Seq_A2780_Human0.96439603
95AHR_22903824_ChIP-Seq_MCF-7_Human0.95966195
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.95908948
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94977350
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.93977547
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93671050
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93464019
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92679824
102SMAD3_21741376_ChIP-Seq_EPCs_Human0.92185488
103SOX3_22085726_ChIP-Seq_NPCs_Mouse0.91793990
104XRN2_22483619_ChIP-Seq_HELA_Human0.91296975
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.90184660
106* FOXP1_21924763_ChIP-Seq_HESCs_Human0.89280630
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88939954
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88782987
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88276987
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87863013
111KLF4_19829295_ChIP-Seq_ESCs_Human0.87715363
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87535521
113CREB1_26743006_Chip-Seq_LNCaP_Human0.86988472
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86824496
115NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86680705
116SMC4_20622854_ChIP-Seq_HELA_Human0.86590419
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85657890
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84423805
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82578899
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82489276
121MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.81927060
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.81768194
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81020053
124* STAT3_23295773_ChIP-Seq_U87_Human0.80195405
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80142599
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79804590
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.79749422
128OCT4_19829295_ChIP-Seq_ESCs_Human0.79660041
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79408501
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78202294
131RNF2_27304074_Chip-Seq_NSC_Mouse0.78043659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.45050138
2MP0004270_analgesia4.14295069
3MP0003635_abnormal_synaptic_transmissio3.83816007
4MP0003880_abnormal_central_pattern3.56821328
5MP0005423_abnormal_somatic_nervous3.23498340
6MP0002063_abnormal_learning/memory/cond3.11210934
7MP0009745_abnormal_behavioral_response2.81857574
8MP0002734_abnormal_mechanical_nocicepti2.67623575
9MP0002064_seizures2.61404468
10MP0000778_abnormal_nervous_system2.60099376
11MP0004858_abnormal_nervous_system2.57020956
12MP0001968_abnormal_touch/_nociception2.54786942
13MP0002822_catalepsy2.36673692
14MP0002572_abnormal_emotion/affect_behav2.32157869
15MP0009046_muscle_twitch2.27704623
16MP0001486_abnormal_startle_reflex2.23945490
17MP0002733_abnormal_thermal_nociception2.20000889
18MP0002184_abnormal_innervation2.13640625
19MP0002735_abnormal_chemical_nociception2.08522510
20MP0009780_abnormal_chondrocyte_physiolo2.07338662
21MP0002272_abnormal_nervous_system2.06928393
22MP0004811_abnormal_neuron_physiology2.05477557
23MP0001188_hyperpigmentation1.98056490
24MP0003329_amyloid_beta_deposits1.96905282
25MP0001970_abnormal_pain_threshold1.91318303
26MP0000955_abnormal_spinal_cord1.86136931
27MP0002736_abnormal_nociception_after1.80879142
28MP0008569_lethality_at_weaning1.77720563
29MP0004885_abnormal_endolymph1.74912736
30MP0001440_abnormal_grooming_behavior1.71982336
31MP0000566_synostosis1.68798736
32MP0002249_abnormal_larynx_morphology1.68431123
33MP0002557_abnormal_social/conspecific_i1.68359675
34MP0002067_abnormal_sensory_capabilities1.63639876
35MP0002882_abnormal_neuron_morphology1.62644731
36MP0003123_paternal_imprinting1.62274030
37MP0001984_abnormal_olfaction1.57438500
38MP0000569_abnormal_digit_pigmentation1.57421554
39MP0002909_abnormal_adrenal_gland1.56933087
40MP0001501_abnormal_sleep_pattern1.55153440
41MP0005386_behavior/neurological_phenoty1.54373853
42MP0004924_abnormal_behavior1.54373853
43MP0000049_abnormal_middle_ear1.53623071
44MP0010030_abnormal_orbit_morphology1.47688174
45MP0003121_genomic_imprinting1.47368768
46MP0005499_abnormal_olfactory_system1.45967890
47MP0005394_taste/olfaction_phenotype1.45967890
48MP0000751_myopathy1.41116124
49MP0002152_abnormal_brain_morphology1.37605430
50MP0002066_abnormal_motor_capabilities/c1.37427168
51MP0001346_abnormal_lacrimal_gland1.26718029
52MP0003879_abnormal_hair_cell1.25204235
53MP0006276_abnormal_autonomic_nervous1.23668268
54MP0003283_abnormal_digestive_organ1.23163208
55MP0008961_abnormal_basal_metabolism1.22623297
56MP0003942_abnormal_urinary_system1.22612949
57MP0001348_abnormal_lacrimal_gland1.18528305
58MP0003634_abnormal_glial_cell1.16585263
59MP0005623_abnormal_meninges_morphology1.16013584
60MP0004145_abnormal_muscle_electrophysio1.15297579
61MP0006292_abnormal_olfactory_placode1.14621812
62MP0002234_abnormal_pharynx_morphology1.13050508
63MP0003861_abnormal_nervous_system1.12120613
64MP0003633_abnormal_nervous_system1.08921138
65MP0003787_abnormal_imprinting1.07148764
66MP0000920_abnormal_myelination1.07080526
67MP0008789_abnormal_olfactory_epithelium1.03934989
68MP0001529_abnormal_vocalization1.03611875
69MP0003136_yellow_coat_color1.01169731
70MP0005187_abnormal_penis_morphology0.99339159
71MP0003631_nervous_system_phenotype0.99336392
72MP0001299_abnormal_eye_distance/0.97195747
73MP0005645_abnormal_hypothalamus_physiol0.97170636
74MP0000026_abnormal_inner_ear0.97114202
75MP0000579_abnormal_nail_morphology0.94101871
76MP0004742_abnormal_vestibular_system0.93827207
77MP0005410_abnormal_fertilization0.93825298
78MP0000537_abnormal_urethra_morphology0.93499596
79MP0004142_abnormal_muscle_tone0.92848034
80MP0003698_abnormal_male_reproductive0.91500425
81MP0000678_abnormal_parathyroid_gland0.89802874
82MP0004233_abnormal_muscle_weight0.89270378
83MP0002752_abnormal_somatic_nervous0.88903092
84MP0002116_abnormal_craniofacial_bone0.88600589
85MP0004133_heterotaxia0.87441308
86MP0002638_abnormal_pupillary_reflex0.87072025
87MP0003632_abnormal_nervous_system0.86780927
88MP0001502_abnormal_circadian_rhythm0.86589252
89MP0000631_abnormal_neuroendocrine_gland0.86293144
90MP0002069_abnormal_eating/drinking_beha0.86223119
91MP0003115_abnormal_respiratory_system0.84643352
92MP0001485_abnormal_pinna_reflex0.84265832
93MP0003122_maternal_imprinting0.84113471
94MP0003137_abnormal_impulse_conducting0.84036636
95MP0001905_abnormal_dopamine_level0.83055759
96MP0009250_abnormal_appendicular_skeleto0.83033959
97MP0003755_abnormal_palate_morphology0.81127741
98MP0009379_abnormal_foot_pigmentation0.81042185
99MP0004085_abnormal_heartbeat0.80346624
100MP0000747_muscle_weakness0.80327877
101MP0002229_neurodegeneration0.79625344
102MP0000604_amyloidosis0.78058621
103MP0005409_darkened_coat_color0.77384091
104MP0001177_atelectasis0.74788669
105MP0009053_abnormal_anal_canal0.74653700
106MP0005670_abnormal_white_adipose0.73527055
107MP0002089_abnormal_postnatal_growth/wei0.73470721
108MP0000534_abnormal_ureter_morphology0.72946414
109MP0002653_abnormal_ependyma_morphology0.72498833
110MP0003935_abnormal_craniofacial_develop0.71876816
111MP0002081_perinatal_lethality0.68971538
112MP0002751_abnormal_autonomic_nervous0.68894888
113MP0003119_abnormal_digestive_system0.67666452
114MP0001943_abnormal_respiration0.66227518
115MP0010769_abnormal_survival0.65837841
116MP0003938_abnormal_ear_development0.64299384
117MP0005646_abnormal_pituitary_gland0.63899239
118MP0003303_peritoneal_inflammation0.63880158
119MP0008874_decreased_physiological_sensi0.63531874
120MP0002082_postnatal_lethality0.62863801
121MP0010770_preweaning_lethality0.62863801
122MP0003385_abnormal_body_wall0.62195179
123MP0010768_mortality/aging0.60823968
124MP0001963_abnormal_hearing_physiology0.60699608
125MP0004510_myositis0.60696363
126MP0003172_abnormal_lysosome_physiology0.59119775

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.60886558
2Focal motor seizures (HP:0011153)4.28880676
3Focal seizures (HP:0007359)4.15498000
4Action tremor (HP:0002345)3.93580052
5Visual hallucinations (HP:0002367)3.87488616
6Supranuclear gaze palsy (HP:0000605)3.86564975
7Ankle clonus (HP:0011448)3.66823103
8Termporal pattern (HP:0011008)3.52272551
9Insidious onset (HP:0003587)3.52272551
10Mutism (HP:0002300)3.14560356
11Insomnia (HP:0100785)3.00300845
12Epileptic encephalopathy (HP:0200134)2.98175572
13Poor eye contact (HP:0000817)2.98126805
14Urinary urgency (HP:0000012)2.92159239
15Abnormality of the lower motor neuron (HP:0002366)2.91171191
16Cerebral inclusion bodies (HP:0100314)2.90579998
17Abnormality of the corticospinal tract (HP:0002492)2.89205663
18Progressive cerebellar ataxia (HP:0002073)2.88499910
19Broad-based gait (HP:0002136)2.82558626
20Megalencephaly (HP:0001355)2.81785639
21Genetic anticipation (HP:0003743)2.80364128
22Urinary bladder sphincter dysfunction (HP:0002839)2.78017552
23Turricephaly (HP:0000262)2.75532210
24Amyotrophic lateral sclerosis (HP:0007354)2.74336992
25Hyperacusis (HP:0010780)2.74193104
26Depression (HP:0000716)2.73628561
27Abnormal social behavior (HP:0012433)2.73165871
28Impaired social interactions (HP:0000735)2.73165871
29Neurofibrillary tangles (HP:0002185)2.66010484
30Obstructive sleep apnea (HP:0002870)2.64533552
31Papilledema (HP:0001085)2.63031549
32Impaired vibration sensation in the lower limbs (HP:0002166)2.62671242
33Abnormality of the aortic arch (HP:0012303)2.59143918
34Limb dystonia (HP:0002451)2.57942818
35Pointed chin (HP:0000307)2.57342417
36Spastic gait (HP:0002064)2.56308044
37Torticollis (HP:0000473)2.53604324
38Apathy (HP:0000741)2.46316845
39Atonic seizures (HP:0010819)2.42841892
40Inappropriate behavior (HP:0000719)2.39765980
41Lower limb amyotrophy (HP:0007210)2.38450828
42Drooling (HP:0002307)2.36734591
43Excessive salivation (HP:0003781)2.36734591
44Macroorchidism (HP:0000053)2.36666056
45Generalized tonic-clonic seizures (HP:0002069)2.36450763
46Absence seizures (HP:0002121)2.36429008
47Amblyopia (HP:0000646)2.35913188
48Dysmetria (HP:0001310)2.33919297
49Akinesia (HP:0002304)2.32078130
50Overriding aorta (HP:0002623)2.31800461
51Deep palmar crease (HP:0006191)2.31089626
52Hemiparesis (HP:0001269)2.30984661
53Shawl scrotum (HP:0000049)2.30917121
54Neoplasm of the heart (HP:0100544)2.27986351
55Truncal ataxia (HP:0002078)2.26728216
56Elfin facies (HP:0004428)2.26410679
57Focal dystonia (HP:0004373)2.24425042
58Sleep apnea (HP:0010535)2.24263577
59Stereotypic behavior (HP:0000733)2.23170732
60Dialeptic seizures (HP:0011146)2.21243840
61Dysdiadochokinesis (HP:0002075)2.20480615
62Shallow orbits (HP:0000586)2.19909349
63Diminished motivation (HP:0000745)2.18319605
64High anterior hairline (HP:0009890)2.17411907
65Annular pancreas (HP:0001734)2.17369576
66Lower limb muscle weakness (HP:0007340)2.15477946
67Intention tremor (HP:0002080)2.14219268
68Febrile seizures (HP:0002373)2.12355971
69Anxiety (HP:0000739)2.11469193
70Hyperthyroidism (HP:0000836)2.07373201
71Abnormal eating behavior (HP:0100738)2.05857083
72Diplopia (HP:0000651)2.05500088
73Abnormality of binocular vision (HP:0011514)2.05500088
74Gaze-evoked nystagmus (HP:0000640)2.04569004
75Craniofacial dystonia (HP:0012179)2.03084272
76Agitation (HP:0000713)2.01247031
77Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00356088
78Hypoplasia of the brainstem (HP:0002365)2.00356088
79Failure to thrive in infancy (HP:0001531)1.99378028
80Retinal dysplasia (HP:0007973)1.97876528
81Postural instability (HP:0002172)1.97560539
82Renal duplication (HP:0000075)1.95990106
83Rapidly progressive (HP:0003678)1.93622227
84Obsessive-compulsive behavior (HP:0000722)1.92507074
85Astrocytoma (HP:0009592)1.90720680
86Abnormality of the astrocytes (HP:0100707)1.90720680
87Progressive inability to walk (HP:0002505)1.90129561
88Impaired smooth pursuit (HP:0007772)1.88715854
89Bronchomalacia (HP:0002780)1.87981972
90Pachygyria (HP:0001302)1.87173674
91Cerebral hypomyelination (HP:0006808)1.86276858
92Rib fusion (HP:0000902)1.85770685
93Renovascular hypertension (HP:0100817)1.85437647
94Neuronal loss in central nervous system (HP:0002529)1.85019446
95Postural tremor (HP:0002174)1.84869372
96Congenital malformation of the right heart (HP:0011723)1.84798691
97Double outlet right ventricle (HP:0001719)1.84798691
98EEG with generalized epileptiform discharges (HP:0011198)1.82024395
99Fetal akinesia sequence (HP:0001989)1.81937664
100Morphological abnormality of the inner ear (HP:0011390)1.81824063
101Sacral dimple (HP:0000960)1.81754347
102Hypsarrhythmia (HP:0002521)1.81250368
103Clonus (HP:0002169)1.81241787
104Hammertoe (HP:0001765)1.80921035
105Disinhibition (HP:0000734)1.80483687
106Epileptiform EEG discharges (HP:0011182)1.79812953
107Aqueductal stenosis (HP:0002410)1.79519339
108Achilles tendon contracture (HP:0001771)1.79456877
109Broad distal phalanx of finger (HP:0009836)1.78369048
110Buphthalmos (HP:0000557)1.78277234
111Patellar aplasia (HP:0006443)1.78154068
112Bradykinesia (HP:0002067)1.77838081
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76894379
114Heterotopia (HP:0002282)1.76478932
115Hemiplegia (HP:0002301)1.75546720
116Truncus arteriosus (HP:0001660)1.75396864
117Dysmetric saccades (HP:0000641)1.75220970
118Abnormality of ocular smooth pursuit (HP:0000617)1.74384533
119Trigonocephaly (HP:0000243)1.72440973
120Abnormality of the labia minora (HP:0012880)1.70058022
121Megalocornea (HP:0000485)1.69633208
122Abnormality of the 4th metacarpal (HP:0010012)1.69497532
123Hypoventilation (HP:0002791)1.69312617
124Abnormal number of incisors (HP:0011064)1.67981580
125Aplasia/Hypoplasia of the patella (HP:0006498)1.67753889
126Precocious puberty (HP:0000826)1.67063507
127Aplasia involving bones of the extremities (HP:0009825)1.67039010
128Aplasia involving bones of the upper limbs (HP:0009823)1.67039010
129Aplasia of the phalanges of the hand (HP:0009802)1.67039010
130Increased nuchal translucency (HP:0010880)1.66885066
131Oligodactyly (HP:0012165)1.65546088
132Peripheral hypomyelination (HP:0007182)1.64349325
133Spina bifida occulta (HP:0003298)1.61625248
134Oligodactyly (hands) (HP:0001180)1.61236104
135Poor suck (HP:0002033)1.60286734
136Polyphagia (HP:0002591)1.58549565
137Renal dysplasia (HP:0000110)1.58462010
138Intellectual disability, moderate (HP:0002342)1.58180727
139Long palpebral fissure (HP:0000637)1.55586345
140Cortical dysplasia (HP:0002539)1.54985457
141Short 4th metacarpal (HP:0010044)1.54104903
142Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.54104903
143Down-sloping shoulders (HP:0200021)1.52251983
144Exotropia (HP:0000577)1.52149029
145Hypoplasia of the corpus callosum (HP:0002079)1.51927717
146Cutaneous finger syndactyly (HP:0010554)1.49942303
147Cutaneous syndactyly (HP:0012725)1.49633884
148Absent epiphyses (HP:0010577)1.49003223
149Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49003223
150Lissencephaly (HP:0001339)1.48834172
151Patellar dislocation (HP:0002999)1.48338952
152Attention deficit hyperactivity disorder (HP:0007018)1.47122884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.24731773
2MAP3K93.59937736
3EPHA43.21831343
4NTRK33.18830642
5CASK2.61004405
6PAK62.60643948
7MINK12.52304066
8DAPK22.42321041
9NTRK22.25133651
10PRKD32.13901779
11MAP3K42.11909356
12KSR22.01562306
13NTRK12.00450598
14CAMK1D1.96479787
15SIK21.94222180
16CAMKK11.89699683
17TYRO31.88755172
18PHKG21.83971599
19PHKG11.83971599
20KSR11.70629488
21TRIB31.70468388
22LATS21.61818442
23UHMK11.57955204
24CDK51.54327233
25ICK1.51404368
26MAPK131.47562774
27TAOK11.46342539
28MAP2K71.32927527
29MARK21.27993329
30ALK1.18796156
31ARAF1.17609517
32PNCK1.17541103
33CSNK1G21.16863001
34MAP2K41.15797637
35CDK121.13141117
36RET1.12517993
37BRAF1.11875977
38DAPK11.09391460
39MAP3K21.07256024
40CDK151.06674764
41PRPF4B1.05138356
42CDK181.04595368
43DYRK21.04455680
44CDK141.03388704
45RIPK11.03125706
46PKN21.02159203
47PLK40.99956263
48TNIK0.98068938
49LIMK10.96878121
50EEF2K0.96199307
51CDK11A0.95057179
52PAK30.94870455
53PRKCG0.91630187
54STK110.90818487
55PIM20.90249044
56CAMK1G0.88479759
57PRKCH0.88437410
58BRD40.86987731
59STK380.86109531
60ERBB30.84654119
61PLK20.83840488
62MTOR0.83573739
63EPHB20.83486350
64DYRK1B0.83238316
65TESK10.82218605
66RPS6KA20.81464875
67GRK50.81133850
68SMG10.79727101
69IRAK20.78503223
70CSNK1A1L0.75910426
71PDGFRA0.75499886
72DDR20.75158869
73CSNK1G30.71532018
74FES0.71414847
75CDK190.68951606
76ERBB20.68083407
77PRKCZ0.67068728
78PINK10.67033654
79AURKA0.65700717
80MAP3K70.65193922
81SCYL20.64216913
82DYRK1A0.62004270
83CAMKK20.61821756
84PKN10.61765877
85CAMK10.60868693
86CAMK2A0.60547616
87FYN0.59075789
88CDC42BPA0.58638426
89LMTK20.58342996
90DMPK0.58231288
91MAPK150.56795774
92BRSK10.56559661
93CAMK2B0.55839164
94SIK10.55536805
95FGFR20.54670782
96NEK20.54152214
97GSK3B0.54091076
98CDK10.53954148
99WNK10.53874998
100CDK20.53099393
101PRKAA10.53092732
102CDC70.52301243
103PTK2B0.51917233
104ROCK20.50041414
105MAPKAPK50.49563135
106RAF10.49477675
107CDK70.48546269
108SGK2230.48040359
109SGK4940.48040359
110NME10.47683707
111CAMK2G0.47114806
112CSNK1G10.46267584
113RPS6KA30.46234797
114RIPK40.46113016
115PRKCI0.44991405
116BMX0.44866025
117CHEK20.44232674
118SGK30.43985385
119ILK0.42634320
120DAPK30.42444706
121PTK20.41787089
122SGK10.41225346
123DYRK30.40585667
124WNK40.40527126
125MAPK100.39835966
126MAPK80.39783198
127MAP3K100.39614198
128CAMK40.39487122
129MAPK90.39320698
130MAPK140.38668322
131MAPK120.36708360
132PDPK10.35578572
133CSNK1E0.35021720
134FGR0.34559651
135MAP2K10.34297696

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.74103962
2Synaptic vesicle cycle_Homo sapiens_hsa047212.61179075
3Nicotine addiction_Homo sapiens_hsa050332.49190607
4Circadian entrainment_Homo sapiens_hsa047132.42094714
5Glutamatergic synapse_Homo sapiens_hsa047242.28324550
6Long-term potentiation_Homo sapiens_hsa047202.21881218
7GABAergic synapse_Homo sapiens_hsa047272.21391660
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12852413
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10628440
10Dopaminergic synapse_Homo sapiens_hsa047282.07596226
11Morphine addiction_Homo sapiens_hsa050322.04546790
12Cholinergic synapse_Homo sapiens_hsa047251.93792985
13Amphetamine addiction_Homo sapiens_hsa050311.93112772
14Axon guidance_Homo sapiens_hsa043601.85521567
15Salivary secretion_Homo sapiens_hsa049701.78715201
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73276170
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68917784
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66430045
19Gap junction_Homo sapiens_hsa045401.66234953
20Gastric acid secretion_Homo sapiens_hsa049711.65210253
21Insulin secretion_Homo sapiens_hsa049111.64776389
22Cocaine addiction_Homo sapiens_hsa050301.61560431
23Oxytocin signaling pathway_Homo sapiens_hsa049211.61196129
24Fatty acid biosynthesis_Homo sapiens_hsa000611.58647490
25Long-term depression_Homo sapiens_hsa047301.54445432
26Glioma_Homo sapiens_hsa052141.47669226
27GnRH signaling pathway_Homo sapiens_hsa049121.47041092
28Renin secretion_Homo sapiens_hsa049241.43204029
29Notch signaling pathway_Homo sapiens_hsa043301.41874666
30Serotonergic synapse_Homo sapiens_hsa047261.36689448
31Sulfur relay system_Homo sapiens_hsa041221.36665944
32Estrogen signaling pathway_Homo sapiens_hsa049151.35763415
33ErbB signaling pathway_Homo sapiens_hsa040121.30086179
34Type II diabetes mellitus_Homo sapiens_hsa049301.28515500
35Taste transduction_Homo sapiens_hsa047421.27188803
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25429268
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24250636
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22792810
39Melanogenesis_Homo sapiens_hsa049161.21261559
40Calcium signaling pathway_Homo sapiens_hsa040201.19804040
41Vitamin B6 metabolism_Homo sapiens_hsa007501.18625255
42cAMP signaling pathway_Homo sapiens_hsa040241.13618906
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.09104260
44Endometrial cancer_Homo sapiens_hsa052131.08584224
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.07980157
46VEGF signaling pathway_Homo sapiens_hsa043701.07843782
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01803033
48Dorso-ventral axis formation_Homo sapiens_hsa043200.99626144
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99610086
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99338755
51mTOR signaling pathway_Homo sapiens_hsa041500.97392823
52Renal cell carcinoma_Homo sapiens_hsa052110.96146895
53Dilated cardiomyopathy_Homo sapiens_hsa054140.96071496
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90143770
55Oocyte meiosis_Homo sapiens_hsa041140.89990526
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89741492
57Colorectal cancer_Homo sapiens_hsa052100.89594189
58AMPK signaling pathway_Homo sapiens_hsa041520.89243137
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87913429
60Choline metabolism in cancer_Homo sapiens_hsa052310.87104959
61mRNA surveillance pathway_Homo sapiens_hsa030150.86524547
62MAPK signaling pathway_Homo sapiens_hsa040100.86085579
63Non-small cell lung cancer_Homo sapiens_hsa052230.84303856
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.80933645
65Rap1 signaling pathway_Homo sapiens_hsa040150.78870953
66Lysine degradation_Homo sapiens_hsa003100.77938570
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77061519
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76105928
69Endocytosis_Homo sapiens_hsa041440.74960036
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.74925447
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73707742
72Ras signaling pathway_Homo sapiens_hsa040140.73222526
73Wnt signaling pathway_Homo sapiens_hsa043100.72785186
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70965243
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70520555
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70089851
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69680424
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68752872
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67856923
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66563690
81Cardiac muscle contraction_Homo sapiens_hsa042600.66473783
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66399754
83Insulin signaling pathway_Homo sapiens_hsa049100.65954058
84Alcoholism_Homo sapiens_hsa050340.65155880
85Hedgehog signaling pathway_Homo sapiens_hsa043400.64852319
86Thyroid hormone synthesis_Homo sapiens_hsa049180.64692062
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64664637
88Melanoma_Homo sapiens_hsa052180.62354884
89Chronic myeloid leukemia_Homo sapiens_hsa052200.62122050
90Hippo signaling pathway_Homo sapiens_hsa043900.61888884
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61780952
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60496755
93Inositol phosphate metabolism_Homo sapiens_hsa005620.60479432
94Biosynthesis of amino acids_Homo sapiens_hsa012300.60239589
95Collecting duct acid secretion_Homo sapiens_hsa049660.60189251
96Base excision repair_Homo sapiens_hsa034100.59859945
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58896510
98Tight junction_Homo sapiens_hsa045300.58426955
99Pancreatic secretion_Homo sapiens_hsa049720.57896799
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57258704
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57087211
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.56877186
103Steroid biosynthesis_Homo sapiens_hsa001000.56587714
104Vibrio cholerae infection_Homo sapiens_hsa051100.56270011
105Cell cycle_Homo sapiens_hsa041100.55395093
106Basal cell carcinoma_Homo sapiens_hsa052170.54843993
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54253934
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53318033
109MicroRNAs in cancer_Homo sapiens_hsa052060.53056426
110Proteoglycans in cancer_Homo sapiens_hsa052050.52761859
111Prion diseases_Homo sapiens_hsa050200.52208399
112Prolactin signaling pathway_Homo sapiens_hsa049170.51436808
113Phototransduction_Homo sapiens_hsa047440.51157742
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49582700
115Chemokine signaling pathway_Homo sapiens_hsa040620.49115458
116Arginine and proline metabolism_Homo sapiens_hsa003300.48468827
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48258052
118Spliceosome_Homo sapiens_hsa030400.48172902
119RNA transport_Homo sapiens_hsa030130.47591807
120Glucagon signaling pathway_Homo sapiens_hsa049220.46552232
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46347787
122Focal adhesion_Homo sapiens_hsa045100.45804976
123Platelet activation_Homo sapiens_hsa046110.45791899
124Pancreatic cancer_Homo sapiens_hsa052120.43889797

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