ANKRD18B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.73201221
2CENP-A containing nucleosome assembly (GO:0034080)4.48194340
3kinetochore organization (GO:0051383)4.37875856
4DNA replication checkpoint (GO:0000076)4.26102579
5histone exchange (GO:0043486)4.24929215
6regulation of centriole replication (GO:0046599)3.86951548
7mitotic metaphase plate congression (GO:0007080)3.85405763
8replication fork processing (GO:0031297)3.84294576
9kinetochore assembly (GO:0051382)3.84039705
10mitotic sister chromatid segregation (GO:0000070)3.83492394
11sister chromatid segregation (GO:0000819)3.63017075
12nuclear pore organization (GO:0006999)3.59757412
13negative regulation of DNA-dependent DNA replication (GO:2000104)3.56644748
14DNA strand elongation involved in DNA replication (GO:0006271)3.55735818
15DNA unwinding involved in DNA replication (GO:0006268)3.55032981
16DNA replication-independent nucleosome organization (GO:0034724)3.54093796
17DNA replication-independent nucleosome assembly (GO:0006336)3.54093796
18maturation of SSU-rRNA (GO:0030490)3.50265813
19nuclear pore complex assembly (GO:0051292)3.49996028
20mitotic sister chromatid cohesion (GO:0007064)3.48789603
21metaphase plate congression (GO:0051310)3.45484668
22DNA replication initiation (GO:0006270)3.40997681
23DNA double-strand break processing (GO:0000729)3.39695298
24protein localization to kinetochore (GO:0034501)3.39349829
25centriole replication (GO:0007099)3.39343841
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.37502615
27meiotic chromosome segregation (GO:0045132)3.37243239
28DNA strand elongation (GO:0022616)3.35009009
29telomere maintenance via semi-conservative replication (GO:0032201)3.26752255
30regulation of centrosome cycle (GO:0046605)3.25480685
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14899317
32ribosomal small subunit assembly (GO:0000028)3.14678689
33regulation of DNA endoreduplication (GO:0032875)3.14380746
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.12266539
35synapsis (GO:0007129)3.10162448
36ribosomal small subunit biogenesis (GO:0042274)3.06935914
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04828461
38regulation of mitotic spindle checkpoint (GO:1903504)3.04828461
39regulation of centrosome duplication (GO:0010824)3.03211835
40heterochromatin organization (GO:0070828)3.02342258
41DNA strand renaturation (GO:0000733)3.01478132
42recombinational repair (GO:0000725)3.00509494
43double-strand break repair via homologous recombination (GO:0000724)3.00227252
44negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.99699229
45telomere maintenance via recombination (GO:0000722)2.97488961
46somatic hypermutation of immunoglobulin genes (GO:0016446)2.95568085
47somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95568085
48regulation of mitochondrial translation (GO:0070129)2.94219574
49mitotic recombination (GO:0006312)2.94075676
50resolution of meiotic recombination intermediates (GO:0000712)2.92982694
51centriole assembly (GO:0098534)2.92557615
52mitotic chromosome condensation (GO:0007076)2.92542419
53pseudouridine synthesis (GO:0001522)2.91524201
54spindle checkpoint (GO:0031577)2.91055925
55DNA replication-dependent nucleosome organization (GO:0034723)2.90327624
56DNA replication-dependent nucleosome assembly (GO:0006335)2.90327624
57negative regulation of chromosome segregation (GO:0051985)2.89195495
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89107130
59negative regulation of sister chromatid segregation (GO:0033046)2.86578245
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86578245
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86578245
62negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86578245
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.86578245
64nucleobase biosynthetic process (GO:0046112)2.86210407
65ribosomal large subunit biogenesis (GO:0042273)2.81269019
66rRNA modification (GO:0000154)2.80595616
67purine nucleobase biosynthetic process (GO:0009113)2.80395602
68chaperone-mediated protein transport (GO:0072321)2.79517950
69regulation of posttranscriptional gene silencing (GO:0060147)2.76938539
70regulation of gene silencing by miRNA (GO:0060964)2.76938539
71regulation of gene silencing by RNA (GO:0060966)2.76938539
72DNA topological change (GO:0006265)2.76823818
73translational termination (GO:0006415)2.75532467
74protein localization to chromosome, centromeric region (GO:0071459)2.75515093
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74360778
76regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74360778
77mitotic spindle checkpoint (GO:0071174)2.73196826
78DNA catabolic process, exonucleolytic (GO:0000738)2.71271244
79pore complex assembly (GO:0046931)2.70509124
80mitotic G2/M transition checkpoint (GO:0044818)2.69538384
81IMP biosynthetic process (GO:0006188)2.69432903
82attachment of spindle microtubules to kinetochore (GO:0008608)2.68998760
83regulation of chromosome segregation (GO:0051983)2.68942390
84ATP-dependent chromatin remodeling (GO:0043044)2.66891540
85regulation of sister chromatid segregation (GO:0033045)2.66663489
86regulation of mitotic sister chromatid separation (GO:0010965)2.66663489
87regulation of mitotic sister chromatid segregation (GO:0033047)2.66663489
88chromatin assembly or disassembly (GO:0006333)2.65158576
89viral transcription (GO:0019083)2.64977764
90non-recombinational repair (GO:0000726)2.62956687
91double-strand break repair via nonhomologous end joining (GO:0006303)2.62956687
92mitotic nuclear envelope disassembly (GO:0007077)2.62800847
93centrosome organization (GO:0051297)2.62665930
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62003846
95establishment of integrated proviral latency (GO:0075713)2.60274001
96energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59440519
97ATP synthesis coupled proton transport (GO:0015986)2.59440519
98rRNA methylation (GO:0031167)2.59422298
99chromosome segregation (GO:0007059)2.59191570
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58969840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.83523009
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08853461
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.05000923
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58853794
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.17613738
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.17391272
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.00588519
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99110412
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.90161101
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.88593603
11VDR_22108803_ChIP-Seq_LS180_Human2.42240928
12ELK1_19687146_ChIP-ChIP_HELA_Human2.27581549
13FUS_26573619_Chip-Seq_HEK293_Human2.24778832
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.23760641
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22805943
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17532672
17EWS_26573619_Chip-Seq_HEK293_Human2.17470393
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15143864
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14288424
20AR_21909140_ChIP-Seq_LNCAP_Human2.11468924
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.08960149
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93559122
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93388174
24ZNF274_21170338_ChIP-Seq_K562_Hela1.92072999
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84507407
26MYC_18940864_ChIP-ChIP_HL60_Human1.83507504
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76379219
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68604135
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66880870
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66501806
31VDR_23849224_ChIP-Seq_CD4+_Human1.57734754
32IGF1R_20145208_ChIP-Seq_DFB_Human1.57278057
33TTF2_22483619_ChIP-Seq_HELA_Human1.57010972
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56002873
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55834415
36FOXP3_21729870_ChIP-Seq_TREG_Human1.54052389
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53406006
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47976917
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47597165
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.45927271
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41472261
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41414921
43DCP1A_22483619_ChIP-Seq_HELA_Human1.38184301
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37791064
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33630870
46XRN2_22483619_ChIP-Seq_HELA_Human1.32902555
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30823365
48P300_19829295_ChIP-Seq_ESCs_Human1.30298533
49TAF15_26573619_Chip-Seq_HEK293_Human1.29875840
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29176329
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28089567
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24738846
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21844214
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.18503403
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.17883133
56GABP_19822575_ChIP-Seq_HepG2_Human1.17201196
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16568911
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16455962
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.13632676
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10979018
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09855612
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09701850
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07629479
64KDM5A_27292631_Chip-Seq_BREAST_Human1.02876857
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02473407
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.02196337
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02017283
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01973761
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01878992
70ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99002471
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97890933
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96091010
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94656407
74ER_23166858_ChIP-Seq_MCF-7_Human0.94234326
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93115597
76GBX2_23144817_ChIP-Seq_PC3_Human0.92444800
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91385343
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88881996
79IRF1_19129219_ChIP-ChIP_H3396_Human0.87264327
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86069188
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85149902
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85086351
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84233733
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82998923
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82950721
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.81988273
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81839929
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81646712
89TP53_22573176_ChIP-Seq_HFKS_Human0.79963264
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.79956528
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78435040
92STAT3_23295773_ChIP-Seq_U87_Human0.77684588
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77338076
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76667471
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76667471
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75405483
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74048640
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73318981
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72276194
100SOX9_26525672_Chip-Seq_HEART_Mouse0.71592147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.75470244
2MP0010094_abnormal_chromosome_stability3.62813796
3MP0003693_abnormal_embryo_hatching3.46407199
4MP0006292_abnormal_olfactory_placode3.12904558
5MP0008058_abnormal_DNA_repair2.92549686
6MP0003136_yellow_coat_color2.87491721
7MP0003111_abnormal_nucleus_morphology2.82064824
8MP0004957_abnormal_blastocyst_morpholog2.66394775
9MP0009379_abnormal_foot_pigmentation2.57944202
10MP0003890_abnormal_embryonic-extraembry2.47926540
11MP0003077_abnormal_cell_cycle2.29922624
12MP0009697_abnormal_copulation2.22010599
13MP0002938_white_spotting2.12540238
14MP0008877_abnormal_DNA_methylation2.03064427
15MP0008932_abnormal_embryonic_tissue1.98322531
16MP0001293_anophthalmia1.88414116
17MP0003941_abnormal_skin_development1.86991787
18MP0000566_synostosis1.86772557
19MP0003937_abnormal_limbs/digits/tail_de1.84490558
20MP0008007_abnormal_cellular_replicative1.71005378
21MP0010030_abnormal_orbit_morphology1.70128813
22MP0003718_maternal_effect1.54959663
23MP0002160_abnormal_reproductive_system1.52955189
24MP0001485_abnormal_pinna_reflex1.47233349
25MP0002697_abnormal_eye_size1.39401685
26MP0001286_abnormal_eye_development1.39376083
27MP0003878_abnormal_ear_physiology1.34475917
28MP0005377_hearing/vestibular/ear_phenot1.34475917
29MP0001188_hyperpigmentation1.32363706
30MP0003315_abnormal_perineum_morphology1.30196514
31MP0002210_abnormal_sex_determination1.26582406
32MP0003123_paternal_imprinting1.26361635
33MP0003786_premature_aging1.25444883
34MP0002234_abnormal_pharynx_morphology1.24389040
35MP0001929_abnormal_gametogenesis1.24365138
36MP0000631_abnormal_neuroendocrine_gland1.23516933
37MP0003119_abnormal_digestive_system1.22115498
38MP0006072_abnormal_retinal_apoptosis1.21556943
39MP0002837_dystrophic_cardiac_calcinosis1.18342152
40MP0002084_abnormal_developmental_patter1.16463728
41MP0005410_abnormal_fertilization1.15689674
42MP0002085_abnormal_embryonic_tissue1.14290513
43MP0002233_abnormal_nose_morphology1.11494339
44MP0003698_abnormal_male_reproductive1.10987215
45MP0003567_abnormal_fetal_cardiomyocyte1.10345483
46MP0000350_abnormal_cell_proliferation1.10295019
47MP0001697_abnormal_embryo_size1.09298452
48MP0000049_abnormal_middle_ear1.09232492
49MP0004147_increased_porphyrin_level1.08794753
50MP0000579_abnormal_nail_morphology1.08307764
51MP0001145_abnormal_male_reproductive1.04943631
52MP0001672_abnormal_embryogenesis/_devel1.04932476
53MP0005380_embryogenesis_phenotype1.04932476
54MP0010307_abnormal_tumor_latency1.04581085
55MP0003755_abnormal_palate_morphology1.03175730
56MP0000428_abnormal_craniofacial_morphol1.02246190
57MP0002102_abnormal_ear_morphology1.01325854
58MP0000653_abnormal_sex_gland0.98688992
59MP0008789_abnormal_olfactory_epithelium0.96743860
60MP0001299_abnormal_eye_distance/0.96594994
61MP0000427_abnormal_hair_cycle0.96538815
62MP0008995_early_reproductive_senescence0.94491152
63MP0003121_genomic_imprinting0.92564547
64MP0005253_abnormal_eye_physiology0.90530269
65MP0004197_abnormal_fetal_growth/weight/0.90466630
66MP0005174_abnormal_tail_pigmentation0.90250672
67MP0003646_muscle_fatigue0.88898224
68MP0005391_vision/eye_phenotype0.88491734
69MP0003984_embryonic_growth_retardation0.87751037
70MP0004215_abnormal_myocardial_fiber0.87496418
71MP0002111_abnormal_tail_morphology0.86131657
72MP0003861_abnormal_nervous_system0.85707977
73MP0009672_abnormal_birth_weight0.85525971
74MP0001730_embryonic_growth_arrest0.85117828
75MP0005551_abnormal_eye_electrophysiolog0.85102184
76MP0002088_abnormal_embryonic_growth/wei0.84929091
77MP0002736_abnormal_nociception_after0.83919671
78MP0001529_abnormal_vocalization0.82813550
79MP0004133_heterotaxia0.81758207
80MP0000569_abnormal_digit_pigmentation0.81272227
81MP0003195_calcinosis0.80728327
82MP0005408_hypopigmentation0.79794813
83MP0002080_prenatal_lethality0.77106024
84MP0005171_absent_coat_pigmentation0.76303266
85MP0005389_reproductive_system_phenotype0.76075384
86MP0000647_abnormal_sebaceous_gland0.76059977
87MP0002095_abnormal_skin_pigmentation0.75337875
88MP0009053_abnormal_anal_canal0.75166942
89MP0003950_abnormal_plasma_membrane0.75061314
90MP0005187_abnormal_penis_morphology0.74820200
91MP0003938_abnormal_ear_development0.74443279
92MP0003186_abnormal_redox_activity0.73566249
93MP0003935_abnormal_craniofacial_develop0.73232999
94MP0003942_abnormal_urinary_system0.73076389
95MP0000372_irregular_coat_pigmentation0.73045344
96MP0002751_abnormal_autonomic_nervous0.72785908
97MP0000762_abnormal_tongue_morphology0.72665423
98MP0006035_abnormal_mitochondrial_morpho0.72521824
99MP0009250_abnormal_appendicular_skeleto0.72144811
100MP0002092_abnormal_eye_morphology0.70826815

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.60265618
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.52734872
3Birth length less than 3rd percentile (HP:0003561)3.82433356
4Reticulocytopenia (HP:0001896)3.55850311
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.42917065
6Abnormality of chromosome stability (HP:0003220)3.39487651
7Meckel diverticulum (HP:0002245)3.33832559
8Volvulus (HP:0002580)3.32598992
9Abnormality of the ileum (HP:0001549)3.24944275
10Colon cancer (HP:0003003)3.00581693
11Abnormality of the preputium (HP:0100587)2.95375000
12Ectopic kidney (HP:0000086)2.88612186
13Small intestinal stenosis (HP:0012848)2.66035316
14Duodenal stenosis (HP:0100867)2.66035316
15Aplasia/Hypoplasia of the sacrum (HP:0008517)2.61816172
16Triphalangeal thumb (HP:0001199)2.57791266
17Intestinal atresia (HP:0011100)2.50875895
18Pancreatic cysts (HP:0001737)2.48513069
19Pancreatic fibrosis (HP:0100732)2.47210808
20Absent thumb (HP:0009777)2.46211997
21Absent radius (HP:0003974)2.45566717
22Abnormality of the duodenum (HP:0002246)2.45380674
23Abnormality of the labia minora (HP:0012880)2.37011466
24Sloping forehead (HP:0000340)2.34707751
25Absent forearm bone (HP:0003953)2.32659855
26Aplasia involving forearm bones (HP:0009822)2.32659855
27Abnormal lung lobation (HP:0002101)2.27373105
28Gastrointestinal atresia (HP:0002589)2.26066520
29Abnormality of the carotid arteries (HP:0005344)2.25671788
30True hermaphroditism (HP:0010459)2.23071175
31Anophthalmia (HP:0000528)2.21544336
32Esophageal atresia (HP:0002032)2.21439261
33Molar tooth sign on MRI (HP:0002419)2.20362373
34Abnormality of midbrain morphology (HP:0002418)2.20362373
35Abnormality of cochlea (HP:0000375)2.16463239
36Septo-optic dysplasia (HP:0100842)2.14871112
37Nephroblastoma (Wilms tumor) (HP:0002667)2.14646468
38Abnormality of cells of the erythroid lineage (HP:0012130)2.14090019
39Abnormal number of incisors (HP:0011064)2.12225340
40Acute necrotizing encephalopathy (HP:0006965)2.12112359
41Cerebellar dysplasia (HP:0007033)2.06207799
42Embryonal renal neoplasm (HP:0011794)2.05855845
43Short thumb (HP:0009778)2.05775578
44Acute encephalopathy (HP:0006846)2.05618440
45Facial cleft (HP:0002006)2.04227937
46Abnormal number of erythroid precursors (HP:0012131)2.03206173
47Macrocytic anemia (HP:0001972)2.02572335
48Oligodactyly (hands) (HP:0001180)2.01085586
49Glioma (HP:0009733)2.00701908
50Horseshoe kidney (HP:0000085)2.00321819
51Chronic hepatic failure (HP:0100626)1.99729140
52Clubbing of toes (HP:0100760)1.98680714
53Patellar aplasia (HP:0006443)1.98020040
54Nephronophthisis (HP:0000090)1.97699703
55Sclerocornea (HP:0000647)1.96707910
56Duplicated collecting system (HP:0000081)1.94794438
57Bifid tongue (HP:0010297)1.94411341
58Rhabdomyosarcoma (HP:0002859)1.93431589
59Bilateral microphthalmos (HP:0007633)1.92396241
60Myelodysplasia (HP:0002863)1.91170241
61Sensory axonal neuropathy (HP:0003390)1.89062112
62Increased nuchal translucency (HP:0010880)1.88508140
63Aplasia/Hypoplasia of the patella (HP:0006498)1.87268690
64Small hand (HP:0200055)1.87216086
65Duplication of thumb phalanx (HP:0009942)1.85415828
66Abnormal mitochondria in muscle tissue (HP:0008316)1.84040169
67Increased CSF lactate (HP:0002490)1.83512055
68Preaxial hand polydactyly (HP:0001177)1.77647389
69Hypoplastic labia majora (HP:0000059)1.77499654
70Hypoplasia of the pons (HP:0012110)1.75487653
71Abnormality of the renal collecting system (HP:0004742)1.74146927
72Mitochondrial inheritance (HP:0001427)1.73606136
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72046443
74Optic nerve hypoplasia (HP:0000609)1.71496400
75Median cleft lip (HP:0000161)1.71439258
76Pallor (HP:0000980)1.71229834
77Abnormality of methionine metabolism (HP:0010901)1.71098569
78Increased hepatocellular lipid droplets (HP:0006565)1.70742649
79Morphological abnormality of the inner ear (HP:0011390)1.69872508
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68844667
81Abnormality of alanine metabolism (HP:0010916)1.68844667
82Hyperalaninemia (HP:0003348)1.68844667
83Absent septum pellucidum (HP:0001331)1.67880133
84Abnormality of the pons (HP:0007361)1.67421756
85Neoplasm of the colon (HP:0100273)1.66547128
86Aplasia/Hypoplasia of the tibia (HP:0005772)1.66536252
87Progressive macrocephaly (HP:0004481)1.66181313
88Anencephaly (HP:0002323)1.64838272
89Lipid accumulation in hepatocytes (HP:0006561)1.64656849
90Dandy-Walker malformation (HP:0001305)1.63996310
91Breast hypoplasia (HP:0003187)1.63447847
92Oligodactyly (HP:0012165)1.63393808
93Astrocytoma (HP:0009592)1.63219592
94Abnormality of the astrocytes (HP:0100707)1.63219592
95Abnormality of the renal medulla (HP:0100957)1.62835077
96Holoprosencephaly (HP:0001360)1.62396116
97Male pseudohermaphroditism (HP:0000037)1.62075663
98Medulloblastoma (HP:0002885)1.61409712
99Cerebral edema (HP:0002181)1.60451263
100Abnormality of the septum pellucidum (HP:0007375)1.60406109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.11395361
2BUB13.09217547
3BMPR1B2.94883042
4FRK2.94359317
5ACVR1B2.80845842
6ZAK2.77756256
7PLK42.73627780
8TTK2.53371474
9VRK22.46348976
10BRSK22.42773686
11STK162.33895641
12WEE12.30384525
13MKNK22.30257749
14NEK12.27342539
15PNCK2.25342120
16PLK32.07413958
17PBK1.98869937
18STK38L1.96677619
19SRPK11.93876115
20NUAK11.89322484
21MKNK11.83902609
22NEK21.78517482
23VRK11.70290410
24CHEK21.69717997
25PLK11.57997544
26NME11.56653861
27TAF11.55440926
28LATS11.46861065
29TSSK61.44111641
30EIF2AK11.42397826
31TGFBR11.31710217
32ATR1.26610378
33INSRR1.25980321
34WNK31.23074343
35STK31.20414850
36AURKB1.13792868
37TNIK1.11465768
38BRSK11.04329600
39TRIM281.00106345
40PINK10.98578901
41ATM0.96838702
42MELK0.94678916
43PLK20.93343309
44TLK10.92830596
45CDK30.91089122
46CHEK10.89040575
47MAP4K20.88492657
48WNK40.86885261
49MARK30.84293663
50BRD40.83694568
51PASK0.81235629
52PDK20.80033006
53STK390.79473668
54BRAF0.78139446
55CAMK1G0.77626176
56NME20.75268061
57OXSR10.72179131
58MUSK0.67237374
59CSNK1E0.66111717
60CASK0.64901335
61CDK10.64535293
62MAP3K90.63862500
63EIF2AK30.63578402
64EPHA40.63492545
65CDK70.62914040
66CDK80.60719251
67AURKA0.56244931
68GRK10.55099352
69CDK20.55086990
70MST40.52926160
71MAP3K40.52661668
72ADRBK20.51255088
73CSNK2A20.49732610
74DYRK30.49269375
75PRKDC0.49001483
76STK40.45548279
77PRKCG0.45231915
78CSNK2A10.45215059
79RPS6KA50.43118110
80LATS20.43066833
81RPS6KB20.40899257
82CAMK1D0.37392797
83CDK40.37048968
84CSNK1G10.34386651
85DMPK0.33604684
86AKT30.33268687
87EIF2AK20.33245520
88FGFR10.32873004
89MAPKAPK50.31265028
90DYRK20.31127977
91CAMK10.30685412
92MAPK140.29815973
93ARAF0.28929063
94GSK3B0.28708332
95FLT30.27853549
96WNK10.26653385
97PRKCI0.25692406
98MAP2K70.25679137
99PRKD30.24934553
100PRKACB0.24007432

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.78211225
2DNA replication_Homo sapiens_hsa030303.54656510
3Mismatch repair_Homo sapiens_hsa034303.54052129
4Ribosome_Homo sapiens_hsa030103.15534369
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05499759
6Fanconi anemia pathway_Homo sapiens_hsa034602.92296616
7One carbon pool by folate_Homo sapiens_hsa006702.60779853
8RNA polymerase_Homo sapiens_hsa030202.60120105
9Non-homologous end-joining_Homo sapiens_hsa034502.47080009
10RNA transport_Homo sapiens_hsa030132.31273362
11Nucleotide excision repair_Homo sapiens_hsa034202.06770518
12Proteasome_Homo sapiens_hsa030502.02564711
13Cell cycle_Homo sapiens_hsa041102.02020553
14Protein export_Homo sapiens_hsa030602.00500364
15Oxidative phosphorylation_Homo sapiens_hsa001901.97486509
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91690840
17Spliceosome_Homo sapiens_hsa030401.89239626
18Basal transcription factors_Homo sapiens_hsa030221.84392539
19RNA degradation_Homo sapiens_hsa030181.80705513
20Parkinsons disease_Homo sapiens_hsa050121.72696017
21Huntingtons disease_Homo sapiens_hsa050161.70496262
22Selenocompound metabolism_Homo sapiens_hsa004501.70394937
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.67262220
24Base excision repair_Homo sapiens_hsa034101.66404916
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66263968
26Pyrimidine metabolism_Homo sapiens_hsa002401.55826176
27Purine metabolism_Homo sapiens_hsa002301.35774804
28Propanoate metabolism_Homo sapiens_hsa006401.25680892
29mRNA surveillance pathway_Homo sapiens_hsa030151.19618503
30Pyruvate metabolism_Homo sapiens_hsa006201.16164117
31Hedgehog signaling pathway_Homo sapiens_hsa043401.13231905
32Alzheimers disease_Homo sapiens_hsa050101.12996052
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05828450
34Oocyte meiosis_Homo sapiens_hsa041141.04054380
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01041489
36p53 signaling pathway_Homo sapiens_hsa041150.99842215
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99818515
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93947339
39Butanoate metabolism_Homo sapiens_hsa006500.91861457
40Nitrogen metabolism_Homo sapiens_hsa009100.89397333
41Cardiac muscle contraction_Homo sapiens_hsa042600.88626604
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86772034
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84630365
44Vitamin B6 metabolism_Homo sapiens_hsa007500.84387449
45Basal cell carcinoma_Homo sapiens_hsa052170.81336848
46Nicotine addiction_Homo sapiens_hsa050330.80715020
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80560691
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80516818
49Lysine degradation_Homo sapiens_hsa003100.79905382
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77435762
51Tryptophan metabolism_Homo sapiens_hsa003800.77356865
52Hippo signaling pathway_Homo sapiens_hsa043900.75008782
53Folate biosynthesis_Homo sapiens_hsa007900.71988326
54Taste transduction_Homo sapiens_hsa047420.71768474
55Phototransduction_Homo sapiens_hsa047440.70739910
56TGF-beta signaling pathway_Homo sapiens_hsa043500.69431920
57Steroid biosynthesis_Homo sapiens_hsa001000.69364002
58Metabolic pathways_Homo sapiens_hsa011000.68874265
59Glutathione metabolism_Homo sapiens_hsa004800.65986657
60Sulfur relay system_Homo sapiens_hsa041220.65500935
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64016471
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63787123
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62604305
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61429371
65Biosynthesis of amino acids_Homo sapiens_hsa012300.60002950
66Wnt signaling pathway_Homo sapiens_hsa043100.58931217
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55104523
68Olfactory transduction_Homo sapiens_hsa047400.54736554
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54282282
70Fatty acid biosynthesis_Homo sapiens_hsa000610.49778607
71beta-Alanine metabolism_Homo sapiens_hsa004100.49283108
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.48593893
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48384437
74Arginine and proline metabolism_Homo sapiens_hsa003300.48340296
75Retinol metabolism_Homo sapiens_hsa008300.48252854
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44498801
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42588639
78Vitamin digestion and absorption_Homo sapiens_hsa049770.40329305
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39832021
80N-Glycan biosynthesis_Homo sapiens_hsa005100.38898894
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35780713
82Fatty acid degradation_Homo sapiens_hsa000710.34401363
83Linoleic acid metabolism_Homo sapiens_hsa005910.34194833
84Melanoma_Homo sapiens_hsa052180.31773495
85Ether lipid metabolism_Homo sapiens_hsa005650.30628451
86Alcoholism_Homo sapiens_hsa050340.29556202
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28882655
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.28677625
89Carbon metabolism_Homo sapiens_hsa012000.28015253
90Fatty acid metabolism_Homo sapiens_hsa012120.27182601
91Chemical carcinogenesis_Homo sapiens_hsa052040.26687841
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25527299
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25499338
94Peroxisome_Homo sapiens_hsa041460.24773496
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21874466
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.21335824
97Systemic lupus erythematosus_Homo sapiens_hsa053220.20320219
98Morphine addiction_Homo sapiens_hsa050320.18423773
99Tyrosine metabolism_Homo sapiens_hsa003500.18334746
100Caffeine metabolism_Homo sapiens_hsa002320.18333630

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