ANKRD18EP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.44264811
2nuclear pore organization (GO:0006999)5.42454737
3pore complex assembly (GO:0046931)4.77470963
4regulation of RNA export from nucleus (GO:0046831)4.48674654
5COPI coating of Golgi vesicle (GO:0048205)4.34200191
6Golgi transport vesicle coating (GO:0048200)4.34200191
7regulation of nucleobase-containing compound transport (GO:0032239)3.94856298
8histone H3-K36 demethylation (GO:0070544)3.89261861
9regulation of histone H3-K27 methylation (GO:0061085)3.83656478
10negative regulation of erythrocyte differentiation (GO:0045647)3.78729033
11embryonic process involved in female pregnancy (GO:0060136)3.67107760
12COPII vesicle coating (GO:0048208)3.61999012
13regulation of DNA damage checkpoint (GO:2000001)3.52284369
14tolerance induction (GO:0002507)3.50358232
15mitotic sister chromatid cohesion (GO:0007064)3.29729626
16definitive hemopoiesis (GO:0060216)3.28381298
17negative regulation of necroptotic process (GO:0060546)3.20606618
18hepatocyte apoptotic process (GO:0097284)3.18767658
19dosage compensation (GO:0007549)3.15480908
20signal complex assembly (GO:0007172)3.14482820
21positive regulation of cell cycle checkpoint (GO:1901978)3.12944459
22histone lysine demethylation (GO:0070076)3.12480339
23positive regulation of granulocyte differentiation (GO:0030854)3.08504918
24negative regulation of necrotic cell death (GO:0060547)3.06963849
25wound healing, spreading of epidermal cells (GO:0035313)3.05748996
26cytoplasmic mRNA processing body assembly (GO:0033962)3.04587978
27peptidyl-threonine dephosphorylation (GO:0035970)3.04075299
28histone demethylation (GO:0016577)2.96388132
29histone H3-K9 demethylation (GO:0033169)2.93882467
30vesicle coating (GO:0006901)2.90040903
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87626692
32regulation of necroptotic process (GO:0060544)2.87558446
33positive regulation of gamma-delta T cell activation (GO:0046645)2.85116919
34peptidyl-lysine dimethylation (GO:0018027)2.83661933
35regulation of cell cycle checkpoint (GO:1901976)2.80273146
36V(D)J recombination (GO:0033151)2.78829043
37regulation of NFAT protein import into nucleus (GO:0051532)2.78122184
38mitotic chromosome condensation (GO:0007076)2.77482318
39regulation of defense response to virus by virus (GO:0050690)2.76828488
40mRNA stabilization (GO:0048255)2.75737893
41RNA stabilization (GO:0043489)2.75737893
42protein demethylation (GO:0006482)2.74430536
43protein dealkylation (GO:0008214)2.74430536
44peptidyl-lysine trimethylation (GO:0018023)2.74166456
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72981550
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.71214038
47nucleus organization (GO:0006997)2.69822704
48DNA synthesis involved in DNA repair (GO:0000731)2.67331649
49DNA unwinding involved in DNA replication (GO:0006268)2.65253411
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65189837
51megakaryocyte development (GO:0035855)2.62362762
52histone H3-K4 trimethylation (GO:0080182)2.58990207
533-UTR-mediated mRNA stabilization (GO:0070935)2.57392582
54response to laminar fluid shear stress (GO:0034616)2.56964972
55protein export from nucleus (GO:0006611)2.54714839
56pyrimidine dimer repair (GO:0006290)2.52911329
57negative T cell selection (GO:0043383)2.52155240
58DNA duplex unwinding (GO:0032508)2.50767489
59negative thymic T cell selection (GO:0045060)2.49653906
60regulation of centriole replication (GO:0046599)2.48703017
61CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.46732169
62T-helper cell differentiation (GO:0042093)2.46732169
63necroptotic process (GO:0070266)2.46691328
64positive regulation of keratinocyte differentiation (GO:0045618)2.46008469
65regulation of gamma-delta T cell differentiation (GO:0045586)2.43667235
66negative regulation of histone methylation (GO:0031061)2.39864974
67poly(A)+ mRNA export from nucleus (GO:0016973)2.39586407
68histone H3-K4 methylation (GO:0051568)2.38945773
69T cell selection (GO:0045058)2.36937156
70response to muramyl dipeptide (GO:0032495)2.36723616
71DNA geometric change (GO:0032392)2.36716203
72regulation of histone methylation (GO:0031060)2.36008316
73thymic T cell selection (GO:0045061)2.35982376
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.33858735
75protein-DNA complex disassembly (GO:0032986)2.33058107
76nucleosome disassembly (GO:0006337)2.33058107
77positive T cell selection (GO:0043368)2.32822058
78spliceosomal tri-snRNP complex assembly (GO:0000244)2.32139957
79nuclear envelope disassembly (GO:0051081)2.31302775
80membrane disassembly (GO:0030397)2.31302775
81nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.30110038
82embryonic camera-type eye morphogenesis (GO:0048596)2.28677135
83histone H3-K9 modification (GO:0061647)2.28637715
84glucocorticoid receptor signaling pathway (GO:0042921)2.27231624
85nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.26868497
86nuclear envelope organization (GO:0006998)2.26521740
87trophectodermal cell differentiation (GO:0001829)2.23750875
88regulation of spindle checkpoint (GO:0090231)2.21917122
89mitotic nuclear envelope disassembly (GO:0007077)2.21194348
90corticosteroid receptor signaling pathway (GO:0031958)2.20791839
91peptidyl-threonine modification (GO:0018210)2.20195869
92intracellular estrogen receptor signaling pathway (GO:0030520)2.19859932
93peptidyl-threonine phosphorylation (GO:0018107)2.18309612
94protein localization to endosome (GO:0036010)2.17151154
95response to lipoprotein particle (GO:0055094)2.15522317
96regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.14187532
97positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.14187532
98cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.14141586
99regulation of gamma-delta T cell activation (GO:0046643)2.14126550
100negative regulation of histone modification (GO:0031057)2.13942067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.77784575
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24701951
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.21846798
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.12205559
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.18633301
6MYC_22102868_ChIP-Seq_BL_Human3.16581457
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64971416
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36829029
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34805457
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33010709
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29714133
12CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.27590924
13GATA1_22025678_ChIP-Seq_K562_Human2.25927982
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24643521
15TCF7_22412390_ChIP-Seq_EML_Mouse2.21636880
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.19943557
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18790572
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13226081
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10150873
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.08649620
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08063300
22RUNX_20019798_ChIP-Seq_JUKART_Human2.05900635
23MYB_26560356_Chip-Seq_TH2_Human2.02930654
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02223900
25MYB_26560356_Chip-Seq_TH1_Human1.99581089
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99335083
27TFEB_21752829_ChIP-Seq_HELA_Human1.85770746
28MAF_26560356_Chip-Seq_TH1_Human1.85676133
29TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.79189437
30PKCTHETA_26484144_Chip-Seq_BREAST_Human1.74921616
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.71307763
32CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69820452
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68147060
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66257273
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.64082571
36CIITA_25753668_ChIP-Seq_RAJI_Human1.61828437
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61230105
38CHD1_26751641_Chip-Seq_LNCaP_Human1.60785101
39SCL_19346495_ChIP-Seq_HPC-7_Human1.57315233
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57080045
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55805441
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.55381138
43KDM2B_26808549_Chip-Seq_DND41_Human1.54105977
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53535680
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49491011
46UTX_26944678_Chip-Seq_JUKART_Human1.48365389
47SPI1_23547873_ChIP-Seq_NB4_Human1.46613412
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45771119
49VDR_21846776_ChIP-Seq_THP-1_Human1.45243524
50KDM5A_27292631_Chip-Seq_BREAST_Human1.42892296
51CLOCK_20551151_ChIP-Seq_293T_Human1.42667106
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40505327
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.40068630
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37471098
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36068979
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36045053
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.34456956
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.34328560
59PU_27001747_Chip-Seq_BMDM_Mouse1.33889349
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33795882
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33262793
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32101071
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31889109
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29375509
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28607882
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28498357
67MAF_26560356_Chip-Seq_TH2_Human1.27439180
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25553623
69AR_21909140_ChIP-Seq_LNCAP_Human1.25007895
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24277341
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.23935948
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.23647274
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23621459
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.20512644
75NCOR1_26117541_ChIP-Seq_K562_Human1.19852877
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.19321366
77GATA3_27048872_Chip-Seq_THYMUS_Human1.19272373
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19094372
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17809025
80VDR_24763502_ChIP-Seq_THP-1_Human1.17643331
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16814417
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15893705
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14451505
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13197417
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12018063
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11490299
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.11160031
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10605029
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10421500
90GATA1_19941826_ChIP-Seq_K562_Human1.10389645
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09640816
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09570027
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09570027
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08128327
95SPI1_23127762_ChIP-Seq_K562_Human1.07445719
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.05804829
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05084374
98GATA2_19941826_ChIP-Seq_K562_Human1.02037890
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00491966
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.99239552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.14647966
2MP0008057_abnormal_DNA_replication3.80885790
3MP0003763_abnormal_thymus_physiology3.03903485
4MP0005451_abnormal_body_composition3.00697172
5MP0002877_abnormal_melanocyte_morpholog2.72848047
6MP0003724_increased_susceptibility_to2.71580565
7MP0003300_gastrointestinal_ulcer2.61252786
8MP0000465_gastrointestinal_hemorrhage2.40534057
9MP0002396_abnormal_hematopoietic_system2.37959462
10MP0005076_abnormal_cell_differentiation2.33004198
11MP0004185_abnormal_adipocyte_glucose2.26986974
12MP0003656_abnormal_erythrocyte_physiolo2.23979974
13MP0004233_abnormal_muscle_weight2.17878413
14MP0002166_altered_tumor_susceptibility2.08662554
15MP0003828_pulmonary_edema2.03822337
16MP0003436_decreased_susceptibility_to2.00970911
17MP0003221_abnormal_cardiomyocyte_apopto1.97728322
18MP0010234_abnormal_vibrissa_follicle1.89103134
19MP0008260_abnormal_autophagy1.81035815
20MP0000703_abnormal_thymus_morphology1.79590158
21MP0003111_abnormal_nucleus_morphology1.79283972
22MP0003693_abnormal_embryo_hatching1.78125738
23MP0010352_gastrointestinal_tract_polyps1.77739971
24MP0004264_abnormal_extraembryonic_tissu1.72798616
25MP0002398_abnormal_bone_marrow1.61647610
26MP0004808_abnormal_hematopoietic_stem1.58343021
27MP0003566_abnormal_cell_adhesion1.50904686
28MP0003077_abnormal_cell_cycle1.50063685
29MP0005397_hematopoietic_system_phenotyp1.47091835
30MP0001545_abnormal_hematopoietic_system1.47091835
31MP0009278_abnormal_bone_marrow1.46653531
32MP0004957_abnormal_blastocyst_morpholog1.41799318
33MP0005464_abnormal_platelet_physiology1.41744366
34MP0003191_abnormal_cellular_cholesterol1.39871327
35MP0002722_abnormal_immune_system1.35622392
36MP0000350_abnormal_cell_proliferation1.30024722
37MP0004947_skin_inflammation1.28501352
38MP0000689_abnormal_spleen_morphology1.28003638
39MP0002006_tumorigenesis1.26831733
40MP0002086_abnormal_extraembryonic_tissu1.24090731
41MP0005621_abnormal_cell_physiology1.24013567
42MP0004381_abnormal_hair_follicle1.22817653
43MP0001873_stomach_inflammation1.18904156
44MP0003984_embryonic_growth_retardation1.18701243
45MP0001800_abnormal_humoral_immune1.18372036
46MP0010094_abnormal_chromosome_stability1.17439965
47MP0001730_embryonic_growth_arrest1.16616730
48MP0003091_abnormal_cell_migration1.16048669
49MP0002088_abnormal_embryonic_growth/wei1.15186167
50MP0005000_abnormal_immune_tolerance1.13767365
51MP0005666_abnormal_adipose_tissue1.13466478
52MP0008007_abnormal_cellular_replicative1.12157391
53MP0005380_embryogenesis_phenotype1.10343130
54MP0001672_abnormal_embryogenesis/_devel1.10343130
55MP0000716_abnormal_immune_system1.09518482
56MP0002429_abnormal_blood_cell1.05294691
57MP0001819_abnormal_immune_cell1.05022865
58MP0008961_abnormal_basal_metabolism1.04214330
59MP0001835_abnormal_antigen_presentation1.04085391
60MP0002420_abnormal_adaptive_immunity1.03047521
61MP0009115_abnormal_fat_cell1.01634681
62MP0008004_abnormal_stomach_pH1.00905014
63MP0009333_abnormal_splenocyte_physiolog0.99788745
64MP0002080_prenatal_lethality0.98938453
65MP0002452_abnormal_antigen_presenting0.98567869
66MP0005409_darkened_coat_color0.98138501
67MP0001697_abnormal_embryo_size0.96508843
68MP0001851_eye_inflammation0.96244292
69MP0005058_abnormal_lysosome_morphology0.96203429
70MP0002723_abnormal_immune_serum0.96130556
71MP0002796_impaired_skin_barrier0.95864405
72MP0001919_abnormal_reproductive_system0.95479851
73MP0004782_abnormal_surfactant_physiolog0.94026260
74MP0008877_abnormal_DNA_methylation0.92808966
75MP0009697_abnormal_copulation0.92204702
76MP0005384_cellular_phenotype0.91833992
77MP0000490_abnormal_crypts_of0.91706390
78MP0008932_abnormal_embryonic_tissue0.90910965
79MP0004197_abnormal_fetal_growth/weight/0.90228955
80MP0002019_abnormal_tumor_incidence0.90114794
81MP0000313_abnormal_cell_death0.90071938
82MP0001533_abnormal_skeleton_physiology0.89058135
83MP0001727_abnormal_embryo_implantation0.88974587
84MP0003943_abnormal_hepatobiliary_system0.87640068
85MP0004130_abnormal_muscle_cell0.86616749
86MP0000858_altered_metastatic_potential0.85535268
87MP0002405_respiratory_system_inflammati0.84542945
88MP0010155_abnormal_intestine_physiology0.83479598
89MP0001915_intracranial_hemorrhage0.80109819
90MP0000003_abnormal_adipose_tissue0.79315809
91MP0009672_abnormal_birth_weight0.75809907
92MP0002419_abnormal_innate_immunity0.75361716
93MP0005501_abnormal_skin_physiology0.75011121
94MP0003453_abnormal_keratinocyte_physiol0.73246360
95MP0009703_decreased_birth_body0.73180263
96MP0004484_altered_response_of0.72024779
97MP0000685_abnormal_immune_system0.71911537
98MP0002822_catalepsy0.71890256
99MP0005257_abnormal_intraocular_pressure0.71567641
100MP0001216_abnormal_epidermal_layer0.70911589

Predicted human phenotypes

RankGene SetZ-score
1Insidious onset (HP:0003587)3.22099072
2Termporal pattern (HP:0011008)3.22099072
3Asymmetry of the thorax (HP:0001555)3.07895064
4Subaortic stenosis (HP:0001682)2.96240814
5Abnormality of the left ventricular outflow tract (HP:0011103)2.96240814
6Curly hair (HP:0002212)2.95926407
7Chromsome breakage (HP:0040012)2.89345887
8Broad face (HP:0000283)2.86943012
9Sparse lateral eyebrow (HP:0005338)2.81633937
10Syringomyelia (HP:0003396)2.77887226
11Spinal cord lesions (HP:0100561)2.77887226
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.75696993
13Papillary thyroid carcinoma (HP:0002895)2.70865886
14Abnormality of the fingertips (HP:0001211)2.59622337
15Abnormal foot bone ossification (HP:0010675)2.55288253
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.54872745
17Abnormal platelet volume (HP:0011876)2.52431888
18Anteriorly placed anus (HP:0001545)2.49162580
19Orthostatic hypotension (HP:0001278)2.48029616
20Deep philtrum (HP:0002002)2.47054980
21Subacute progressive viral hepatitis (HP:0006572)2.46303813
22Long palpebral fissure (HP:0000637)2.45889311
23Spontaneous hematomas (HP:0007420)2.41908644
24T lymphocytopenia (HP:0005403)2.38042876
25Stomatitis (HP:0010280)2.37938083
26Germ cell neoplasia (HP:0100728)2.35787668
27Thyroid carcinoma (HP:0002890)2.33827095
28Increased mean platelet volume (HP:0011877)2.33557458
29Broad nasal tip (HP:0000455)2.31354738
30Hyperacusis (HP:0010780)2.22202462
31Flat acetabular roof (HP:0003180)2.21497334
32Prolonged bleeding time (HP:0003010)2.12775390
33Bladder neoplasm (HP:0009725)2.10357448
34Bladder carcinoma (HP:0002862)2.10357448
35Relative macrocephaly (HP:0004482)2.08445389
36Abnormality of the columella (HP:0009929)2.06659317
37Exercise-induced myalgia (HP:0003738)2.06349367
38Papilledema (HP:0001085)2.05562859
39Cutis marmorata (HP:0000965)2.04634360
40Abnormal tarsal ossification (HP:0008369)2.04223399
41Overlapping toe (HP:0001845)2.02433279
42Acute myeloid leukemia (HP:0004808)2.02374417
43Transitional cell carcinoma of the bladder (HP:0006740)2.02068951
44Recurrent viral infections (HP:0004429)1.99998136
45Microglossia (HP:0000171)1.98271724
46Cutaneous melanoma (HP:0012056)1.98208556
47Exostoses (HP:0100777)1.96940732
48Self-mutilation (HP:0000742)1.92576417
49Micronodular cirrhosis (HP:0001413)1.92463810
50Septate vagina (HP:0001153)1.92214248
51Dysmetric saccades (HP:0000641)1.90991300
52Eczematoid dermatitis (HP:0000976)1.90876731
53Abnormal ossification of hand bones (HP:0005921)1.90026452
54Ankyloglossia (HP:0010296)1.89039627
55Dislocated radial head (HP:0003083)1.88307366
56Tubulointerstitial nephritis (HP:0001970)1.87757340
57Autoamputation (HP:0001218)1.87649761
58Basal cell carcinoma (HP:0002671)1.87585340
59Abnormality of carpal bone ossification (HP:0006257)1.84476080
60Coarse hair (HP:0002208)1.83877136
61Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83328349
62Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82722693
63Heterotopia (HP:0002282)1.82718998
64Leiomyosarcoma (HP:0100243)1.82006413
65Uterine leiomyosarcoma (HP:0002891)1.82006413
66Neonatal hypoglycemia (HP:0001998)1.81486994
67Sandal gap (HP:0001852)1.81275793
68Abnormality of T cell number (HP:0011839)1.79991264
69Centrally nucleated skeletal muscle fibers (HP:0003687)1.78270044
70Unilateral renal agenesis (HP:0000122)1.78167731
71Viral hepatitis (HP:0006562)1.76838733
72Fatigue (HP:0012378)1.76371164
73Menorrhagia (HP:0000132)1.75607854
74Reticulocytosis (HP:0001923)1.74994105
75Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71140683
76Medulloblastoma (HP:0002885)1.70698194
77Poikiloderma (HP:0001029)1.69782950
78Elevated alkaline phosphatase (HP:0003155)1.68869255
79Abnormality of the radial head (HP:0003995)1.68546766
80Autoimmune hemolytic anemia (HP:0001890)1.67935164
81B lymphocytopenia (HP:0010976)1.67793263
82Abnormal hand bone ossification (HP:0010660)1.67351049
83Truncal obesity (HP:0001956)1.66351458
84Long eyelashes (HP:0000527)1.66135207
85Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65133290
86Colitis (HP:0002583)1.64130909
87Progressive hearing impairment (HP:0001730)1.63698489
88Nephroblastoma (Wilms tumor) (HP:0002667)1.61974408
89Malignant gastrointestinal tract tumors (HP:0006749)1.60371990
90Gastrointestinal carcinoma (HP:0002672)1.60371990
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.59088934
92Slow saccadic eye movements (HP:0000514)1.58736362
93Prominent nose (HP:0000448)1.57544008
94Episodic fever (HP:0001954)1.57427079
95Abnormality of T cells (HP:0002843)1.56981505
96Granulocytopenia (HP:0001913)1.56235146
97Tetraparesis (HP:0002273)1.56036416
98Abnormality of oral frenula (HP:0000190)1.54215561
99Acanthocytosis (HP:0001927)1.53867143
100Cubitus valgus (HP:0002967)1.53623455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.08270727
2SCYL23.41638436
3PRPF4B3.18700378
4CDK82.76145249
5TRIB32.65221756
6MAP3K102.64366040
7SIK32.60425105
8ICK2.54498899
9PKN22.20169462
10PLK42.18912334
11BRD42.17530319
12MAP3K141.97915803
13EEF2K1.55807740
14FGFR41.55555741
15RPS6KB21.50885945
16KSR21.48636332
17MAP4K11.44767868
18RIPK41.41589469
19SIK11.38956894
20YES11.38118959
21GRK61.35741139
22CDK61.32394682
23LATS11.23315904
24MAP2K71.15909327
25IRAK31.14808855
26FGFR31.13725565
27PDGFRA1.11721877
28RET1.11106493
29RAF11.08850566
30EPHA31.04971566
31BTK1.03146244
32MAP3K21.03009582
33AKT31.01476648
34SGK31.01341830
35CAMKK21.00259099
36DYRK30.97386164
37EIF2AK10.96014467
38ZAP700.95438322
39NLK0.95259946
40RPS6KA40.94182059
41JAK10.93384465
42MAP3K10.93251065
43MAP2K20.91379573
44KSR10.89069429
45HCK0.88043454
46ERBB30.87874563
47MAP2K30.87301836
48CDK40.86315231
49EPHB10.82301796
50MTOR0.81873944
51JAK20.81216513
52BCR0.79924714
53CDK90.78706144
54CDK70.78040137
55NEK60.77638732
56MAP3K70.76982108
57PDGFRB0.75516233
58MAP3K130.75506027
59MST40.74863308
60CAMK1D0.74848563
61SMG10.73987371
62MARK30.73384077
63NEK90.73064461
64SGK20.71979668
65MAP3K60.70662562
66RPS6KB10.66227922
67DYRK1B0.65438155
68MAP2K10.65156367
69SRPK10.64994370
70PASK0.64439030
71TAF10.64408973
72JAK30.63745750
73TESK10.63695826
74MAP3K40.62763147
75MAPK110.56790105
76CAMK1G0.53683013
77ITK0.53146656
78HIPK20.52882705
79MATK0.51596376
80TRPM70.49975906
81WNK10.49838851
82CHEK10.49023220
83TYK20.46533697
84CLK10.46259795
85LCK0.46160638
86CSK0.46110960
87ALK0.45223213
88TTK0.44032821
89ATM0.43242293
90CAMK40.41161054
91PIM10.40666295
92IKBKE0.40374163
93ATR0.39976359
94TRIM280.39644036
95DMPK0.39314029
96EIF2AK30.37838936
97STK380.36500447
98SIK20.36290531
99STK30.36211034
100STK100.35905721

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052162.75626816
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37070874
3Non-small cell lung cancer_Homo sapiens_hsa052232.30890459
4Acute myeloid leukemia_Homo sapiens_hsa052212.22689369
5T cell receptor signaling pathway_Homo sapiens_hsa046602.10353769
6Chronic myeloid leukemia_Homo sapiens_hsa052202.03011249
7Endometrial cancer_Homo sapiens_hsa052132.00086938
8Pancreatic cancer_Homo sapiens_hsa052121.91414585
9B cell receptor signaling pathway_Homo sapiens_hsa046621.85037229
10mTOR signaling pathway_Homo sapiens_hsa041501.73533198
11Renal cell carcinoma_Homo sapiens_hsa052111.59687392
12Hepatitis B_Homo sapiens_hsa051611.59491151
13Colorectal cancer_Homo sapiens_hsa052101.58565305
14Prostate cancer_Homo sapiens_hsa052151.58524293
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53225804
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.45017191
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44590415
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39536587
19ErbB signaling pathway_Homo sapiens_hsa040121.38582126
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37284390
21Measles_Homo sapiens_hsa051621.34969079
22Viral carcinogenesis_Homo sapiens_hsa052031.34347394
23Prolactin signaling pathway_Homo sapiens_hsa049171.33145160
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31869577
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.30130379
26Osteoclast differentiation_Homo sapiens_hsa043801.25775256
27Non-homologous end-joining_Homo sapiens_hsa034501.24616204
28VEGF signaling pathway_Homo sapiens_hsa043701.23718964
29Shigellosis_Homo sapiens_hsa051311.23648112
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22806135
31Choline metabolism in cancer_Homo sapiens_hsa052311.20099272
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18867580
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18766329
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17109572
35TNF signaling pathway_Homo sapiens_hsa046681.16418165
36Inositol phosphate metabolism_Homo sapiens_hsa005621.15540673
37Adherens junction_Homo sapiens_hsa045201.13984993
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12786987
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10845658
40Glioma_Homo sapiens_hsa052141.10179601
41Cell cycle_Homo sapiens_hsa041101.09344382
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07401526
43FoxO signaling pathway_Homo sapiens_hsa040681.07150167
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.06641102
45Apoptosis_Homo sapiens_hsa042101.06010386
46Insulin signaling pathway_Homo sapiens_hsa049101.02977259
47AMPK signaling pathway_Homo sapiens_hsa041521.01492047
48Hepatitis C_Homo sapiens_hsa051601.01207234
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00941528
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00091337
51MicroRNAs in cancer_Homo sapiens_hsa052060.99623451
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.99061502
53Herpes simplex infection_Homo sapiens_hsa051680.98572443
54mRNA surveillance pathway_Homo sapiens_hsa030150.98285449
55Bladder cancer_Homo sapiens_hsa052190.96915524
56Platelet activation_Homo sapiens_hsa046110.94785147
57Small cell lung cancer_Homo sapiens_hsa052220.94770634
58Insulin resistance_Homo sapiens_hsa049310.91482343
59Other glycan degradation_Homo sapiens_hsa005110.90136467
60Type II diabetes mellitus_Homo sapiens_hsa049300.89913118
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88891581
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.88662311
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87762411
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87440314
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87047724
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86358639
67RNA transport_Homo sapiens_hsa030130.84986320
68Toxoplasmosis_Homo sapiens_hsa051450.83147812
69Influenza A_Homo sapiens_hsa051640.82689084
70Primary immunodeficiency_Homo sapiens_hsa053400.80034927
71Chemokine signaling pathway_Homo sapiens_hsa040620.76781201
72Estrogen signaling pathway_Homo sapiens_hsa049150.76397427
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74345809
74Circadian rhythm_Homo sapiens_hsa047100.74218006
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.73008390
76Proteoglycans in cancer_Homo sapiens_hsa052050.72358626
77Epstein-Barr virus infection_Homo sapiens_hsa051690.72222022
78HIF-1 signaling pathway_Homo sapiens_hsa040660.70277120
79Legionellosis_Homo sapiens_hsa051340.70185072
80Endocytosis_Homo sapiens_hsa041440.68725691
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.68034671
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.66605284
83Leishmaniasis_Homo sapiens_hsa051400.66323393
84Fatty acid biosynthesis_Homo sapiens_hsa000610.65322513
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64422014
86HTLV-I infection_Homo sapiens_hsa051660.62159652
87Sphingolipid metabolism_Homo sapiens_hsa006000.61565995
88Dorso-ventral axis formation_Homo sapiens_hsa043200.59823305
89Melanoma_Homo sapiens_hsa052180.57695211
90Long-term potentiation_Homo sapiens_hsa047200.55503061
91Nucleotide excision repair_Homo sapiens_hsa034200.52816916
92Tuberculosis_Homo sapiens_hsa051520.52445353
93Alcoholism_Homo sapiens_hsa050340.52065830
94Spliceosome_Homo sapiens_hsa030400.51373038
95GnRH signaling pathway_Homo sapiens_hsa049120.48768353
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47829509
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46668539
98MAPK signaling pathway_Homo sapiens_hsa040100.46497251
99N-Glycan biosynthesis_Homo sapiens_hsa005100.46356137
100Basal transcription factors_Homo sapiens_hsa030220.46108520

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