ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	central nervous system myelination (GO:0022010)	5.84563515
2	axon ensheathment in central nervous system (GO:0032291)	5.84563515
3	nephron epithelium morphogenesis (GO:0072088)	4.92652472
4	nephron tubule morphogenesis (GO:0072078)	4.92652472
5	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	4.65884412
6	neuron fate determination (GO:0048664)	4.64377148
7	negative regulation of astrocyte differentiation (GO:0048712)	4.49900029
8	auditory receptor cell differentiation (GO:0042491)	4.42659676
9	neuronal stem cell maintenance (GO:0097150)	4.40007043
10	renal tubule morphogenesis (GO:0061333)	4.31973539
11	otic vesicle formation (GO:0030916)	4.06887503
12	tongue development (GO:0043586)	4.06758196
13	centriole replication (GO:0007099)	3.87298942
14	neuronal action potential propagation (GO:0019227)	3.74983211
15	presynaptic membrane assembly (GO:0097105)	3.74298594
16	astrocyte differentiation (GO:0048708)	3.74183104
17	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.71849922
18	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.56270809
19	postsynaptic membrane organization (GO:0001941)	3.55492835
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.45321848
21	pattern specification involved in kidney development (GO:0061004)	3.43215638
22	membrane depolarization during action potential (GO:0086010)	3.37653743
23	negative regulation of inclusion body assembly (GO:0090084)	3.37026136
24	cerebral cortex radially oriented cell migration (GO:0021799)	3.36188056
25	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.33822087
26	inner ear receptor cell differentiation (GO:0060113)	3.28082598
27	regulation of microtubule-based movement (GO:0060632)	3.23249982
28	heart valve formation (GO:0003188)	3.19594517
29	adaptation of signaling pathway (GO:0023058)	3.19551303
30	neuronal action potential (GO:0019228)	3.18010435
31	multicellular organism reproduction (GO:0032504)	3.17402727
32	presynaptic membrane organization (GO:0097090)	3.14716406
33	cilium or flagellum-dependent cell motility (GO:0001539)	3.13113818
34	gamma-aminobutyric acid transport (GO:0015812)	3.08253216
35	forebrain neuron differentiation (GO:0021879)	3.06334817
36	nonmotile primary cilium assembly (GO:0035058)	3.05676583
37	behavioral response to nicotine (GO:0035095)	3.04297416
38	epithelial cilium movement (GO:0003351)	3.03918932
39	limb bud formation (GO:0060174)	3.03489760
40	protein polyglutamylation (GO:0018095)	3.01854720
41	male sex determination (GO:0030238)	2.95795896
42	startle response (GO:0001964)	2.92820166
43	regulation of male gonad development (GO:2000018)	2.91532979
44	positive regulation of vascular permeability (GO:0043117)	2.91465081
45	positive regulation of male gonad development (GO:2000020)	2.90870537
46	axonemal dynein complex assembly (GO:0070286)	2.88107716
47	axoneme assembly (GO:0035082)	2.87690150
48	protein localization to synapse (GO:0035418)	2.86162642
49	neuron cell-cell adhesion (GO:0007158)	2.84965305
50	sperm motility (GO:0030317)	2.84934666
51	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.84427315
52	negative regulation of glial cell differentiation (GO:0045686)	2.83285103
53	regulation of cellular respiration (GO:0043457)	2.82279972
54	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.81794129
55	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.79982624
56	radial glial cell differentiation (GO:0060019)	2.78990166
57	regulation of cilium movement (GO:0003352)	2.77433532
58	mechanoreceptor differentiation (GO:0042490)	2.77411619
59	negative regulation of response to food (GO:0032096)	2.75856052
60	negative regulation of appetite (GO:0032099)	2.75856052
61	cilium movement (GO:0003341)	2.74044365
62	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.73596858
63	auditory behavior (GO:0031223)	2.71462951
64	retina layer formation (GO:0010842)	2.70732230
65	telencephalon development (GO:0021537)	2.68267543
66	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.67019413
67	L-fucose catabolic process (GO:0042355)	2.63275799
68	fucose catabolic process (GO:0019317)	2.63275799
69	L-fucose metabolic process (GO:0042354)	2.63275799
70	cilium organization (GO:0044782)	2.62125012
71	cochlea development (GO:0090102)	2.61308421
72	regulation of glucokinase activity (GO:0033131)	2.61117534
73	regulation of hexokinase activity (GO:1903299)	2.61117534
74	cellular ketone body metabolic process (GO:0046950)	2.59087034
75	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.58306782
76	centriole assembly (GO:0098534)	2.57845833
77	negative regulation of telomere maintenance (GO:0032205)	2.57396118
78	nephron tubule formation (GO:0072079)	2.54923918
79	resolution of meiotic recombination intermediates (GO:0000712)	2.54512987
80	mechanosensory behavior (GO:0007638)	2.53717080
81	protein refolding (GO:0042026)	2.53487593
82	regulation of response to food (GO:0032095)	2.53177056
83	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.50640751
84	neurotransmitter-gated ion channel clustering (GO:0072578)	2.50503381
85	glutamate receptor signaling pathway (GO:0007215)	2.50192257
86	negative regulation of mast cell activation (GO:0033004)	2.49757836
87	spermatid nucleus differentiation (GO:0007289)	2.48655410
88	synaptic transmission, glutamatergic (GO:0035249)	2.48348414
89	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.47806291
90	regulation of astrocyte differentiation (GO:0048710)	2.45467055
91	cilium assembly (GO:0042384)	2.45106501
92	mannosylation (GO:0097502)	2.43767320
93	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.40424390
94	regulation of action potential (GO:0098900)	2.40334778
95	replication fork processing (GO:0031297)	2.38298337
96	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.38234162
97	substrate-independent telencephalic tangential migration (GO:0021826)	2.38234162
98	hindbrain development (GO:0030902)	2.37445546
99	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.37165580
100	ATP synthesis coupled proton transport (GO:0015986)	2.36420107

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.11712275
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.22153035
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84834801
4	VDR_22108803_ChIP-Seq_LS180_Human	2.63095587
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51716177
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.38460531
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.33597056
8	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.30896032
9	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30672638
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28773614
11	FUS_26573619_Chip-Seq_HEK293_Human	2.18845049
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.08919392
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.99287356
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98238568
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.95709999
16	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.88795786
17	P300_19829295_ChIP-Seq_ESCs_Human	1.87743438
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.85140501
19	* TAF15_26573619_Chip-Seq_HEK293_Human	1.84045488
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.83403562
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79412084
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78501510
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.78501510
24	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.78018298
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.77937995
26	EWS_26573619_Chip-Seq_HEK293_Human	1.74478178
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.74227380
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71499822
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.69507887
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67733265
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.67354033
32	* ER_23166858_ChIP-Seq_MCF-7_Human	1.66195566
33	AR_25329375_ChIP-Seq_VCAP_Human	1.63350812
34	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.60845544
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57566948
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57371269
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56923368
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56610110
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54845452
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54701729
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53177485
42	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.53103536
43	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.53055547
44	STAT3_23295773_ChIP-Seq_U87_Human	1.52470221
45	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.51585259
46	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.50646410
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.48420941
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47524927
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.47524927
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44381755
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43951697
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42889232
53	TCF4_23295773_ChIP-Seq_U87_Human	1.42674226
54	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41871308
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41472664
56	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.41196374
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.40916182
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40314297
59	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.39216790
60	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.39216790
61	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.39184233
62	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38519231
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.37781182
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37048735
65	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.36773928
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33961686
67	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33874028
68	TP53_16413492_ChIP-PET_HCT116_Human	1.30589855
69	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29490969
70	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.29437896
71	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27963031
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.26593104
73	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.25341903
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.23701745
75	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.23255676
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22041181
77	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18838929
78	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18223564
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15883925
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15755987
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.14930434
82	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14406474
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13937266
84	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13248430
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13121389
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13068578
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12946678
88	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11961654
89	MYC_18940864_ChIP-ChIP_HL60_Human	1.11804702
90	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11724895
91	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11724895
92	JUN_21703547_ChIP-Seq_K562_Human	1.09504399
93	TP53_22573176_ChIP-Seq_HFKS_Human	1.09231930
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08312240
95	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.07808797
96	RXR_22108803_ChIP-Seq_LS180_Human	1.04645665
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03059664
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03047496
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02409118
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01820701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.74830133
2	MP0004885_abnormal_endolymph	3.55905078
3	MP0001485_abnormal_pinna_reflex	3.00567561
4	MP0001968_abnormal_touch/_nociception	2.54044896
5	MP0002638_abnormal_pupillary_reflex	2.47556787
6	MP0002736_abnormal_nociception_after	2.45674207
7	MP0003880_abnormal_central_pattern	2.38800076
8	MP0004742_abnormal_vestibular_system	2.37503069
9	MP0008877_abnormal_DNA_methylation	2.20114536
10	MP0009745_abnormal_behavioral_response	2.06505297
11	MP0005551_abnormal_eye_electrophysiolog	2.05790157
12	MP0004142_abnormal_muscle_tone	2.05112055
13	MP0002272_abnormal_nervous_system	2.04117221
14	MP0006292_abnormal_olfactory_placode	2.03829976
15	MP0002822_catalepsy	1.90563423
16	MP0003787_abnormal_imprinting	1.89254483
17	MP0001486_abnormal_startle_reflex	1.82353948
18	MP0001984_abnormal_olfaction	1.79975682
19	MP0004147_increased_porphyrin_level	1.78303583
20	MP0006072_abnormal_retinal_apoptosis	1.77577622
21	MP0001529_abnormal_vocalization	1.75783830
22	MP0000631_abnormal_neuroendocrine_gland	1.75517777
23	MP0003635_abnormal_synaptic_transmissio	1.73364913
24	MP0009384_cardiac_valve_regurgitation	1.72323974
25	MP0002102_abnormal_ear_morphology	1.70291104
26	MP0005646_abnormal_pituitary_gland	1.69817883
27	MP0009046_muscle_twitch	1.69137980
28	MP0002064_seizures	1.68551696
29	MP0002067_abnormal_sensory_capabilities	1.66011285
30	MP0005423_abnormal_somatic_nervous	1.63809933
31	MP0000566_synostosis	1.56135273
32	MP0001986_abnormal_taste_sensitivity	1.54988990
33	MP0002572_abnormal_emotion/affect_behav	1.53319248
34	MP0000026_abnormal_inner_ear	1.52100633
35	MP0005253_abnormal_eye_physiology	1.50544254
36	MP0000049_abnormal_middle_ear	1.49828790
37	MP0002653_abnormal_ependyma_morphology	1.49468030
38	MP0002557_abnormal_social/conspecific_i	1.48996010
39	MP0001963_abnormal_hearing_physiology	1.39885721
40	MP0000569_abnormal_digit_pigmentation	1.38456643
41	MP0003283_abnormal_digestive_organ	1.38187508
42	MP0003122_maternal_imprinting	1.37697155
43	MP0002735_abnormal_chemical_nociception	1.36569972
44	MP0002063_abnormal_learning/memory/cond	1.36226231
45	MP0004043_abnormal_pH_regulation	1.35820475
46	MP0000778_abnormal_nervous_system	1.35320677
47	MP0002938_white_spotting	1.34104401
48	MP0004270_analgesia	1.33123126
49	MP0002249_abnormal_larynx_morphology	1.32659565
50	MP0002734_abnormal_mechanical_nocicepti	1.30615183
51	MP0004859_abnormal_synaptic_plasticity	1.29773201
52	MP0002733_abnormal_thermal_nociception	1.28624687
53	MP0003878_abnormal_ear_physiology	1.25992157
54	MP0005377_hearing/vestibular/ear_phenot	1.25992157
55	MP0001970_abnormal_pain_threshold	1.25924682
56	MP0003121_genomic_imprinting	1.24738188
57	MP0005195_abnormal_posterior_eye	1.22555668
58	MP0008872_abnormal_physiological_respon	1.21628087
59	MP0000427_abnormal_hair_cycle	1.20773178
60	MP0002282_abnormal_trachea_morphology	1.19143985
61	MP0000955_abnormal_spinal_cord	1.18135452
62	MP0003195_calcinosis	1.16156909
63	MP0004924_abnormal_behavior	1.15988381
64	MP0005386_behavior/neurological_phenoty	1.15988381
65	MP0008058_abnormal_DNA_repair	1.12881224
66	MP0001905_abnormal_dopamine_level	1.10811035
67	MP0005187_abnormal_penis_morphology	1.09311097
68	MP0006276_abnormal_autonomic_nervous	1.09171531
69	MP0001929_abnormal_gametogenesis	1.07949802
70	MP0002184_abnormal_innervation	1.07748625
71	MP0004133_heterotaxia	1.06982930
72	MP0002752_abnormal_somatic_nervous	1.02789556
73	MP0002882_abnormal_neuron_morphology	1.02738159
74	MP0003698_abnormal_male_reproductive	1.01909551
75	MP0002160_abnormal_reproductive_system	1.01504074
76	MP0001764_abnormal_homeostasis	1.00789018
77	MP0001502_abnormal_circadian_rhythm	1.00575099
78	MP0002229_neurodegeneration	0.99019494
79	MP0002837_dystrophic_cardiac_calcinosis	0.96695182
80	MP0005410_abnormal_fertilization	0.94724364
81	MP0002234_abnormal_pharynx_morphology	0.94571216
82	MP0005391_vision/eye_phenotype	0.93326127
83	MP0003755_abnormal_palate_morphology	0.89997529
84	MP0002928_abnormal_bile_duct	0.89262144
85	MP0005174_abnormal_tail_pigmentation	0.88319742
86	MP0002210_abnormal_sex_determination	0.87285448
87	MP0003633_abnormal_nervous_system	0.87228359
88	MP0002095_abnormal_skin_pigmentation	0.87040588
89	MP0009780_abnormal_chondrocyte_physiolo	0.86345753
90	MP0001299_abnormal_eye_distance/	0.84977034
91	MP0001293_anophthalmia	0.84568101
92	MP0002152_abnormal_brain_morphology	0.83913460
93	MP0005084_abnormal_gallbladder_morpholo	0.83889237
94	MP0000534_abnormal_ureter_morphology	0.82616858
95	MP0000613_abnormal_salivary_gland	0.82227682
96	MP0003890_abnormal_embryonic-extraembry	0.81899535
97	MP0001270_distended_abdomen	0.80234378
98	MP0001440_abnormal_grooming_behavior	0.79206686
99	MP0001324_abnormal_eye_pigmentation	0.78203828
100	MP0000647_abnormal_sebaceous_gland	0.78126404

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.37528657
2	Molar tooth sign on MRI (HP:0002419)	4.37528657
3	True hermaphroditism (HP:0010459)	4.27025869
4	Hypoplastic iliac wings (HP:0002866)	3.77607717
5	Medial flaring of the eyebrow (HP:0010747)	3.59190341
6	11 pairs of ribs (HP:0000878)	3.45990856
7	Pancreatic fibrosis (HP:0100732)	3.44085835
8	Nephronophthisis (HP:0000090)	3.38076324
9	Hyperventilation (HP:0002883)	3.34653391
10	Type II lissencephaly (HP:0007260)	3.23483541
11	Pancreatic cysts (HP:0001737)	3.11356881
12	Chronic hepatic failure (HP:0100626)	2.99125274
13	Cerebellar dysplasia (HP:0007033)	2.96483579
14	Tubular atrophy (HP:0000092)	2.86731618
15	Morphological abnormality of the inner ear (HP:0011390)	2.81498261
16	Abnormality of the renal medulla (HP:0100957)	2.79499047
17	Abnormal ciliary motility (HP:0012262)	2.76095011
18	Gait imbalance (HP:0002141)	2.75355512
19	Abnormality of the renal cortex (HP:0011035)	2.71260846
20	Abnormal sex determination (HP:0012244)	2.69492596
21	Sex reversal (HP:0012245)	2.69492596
22	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.60269778
23	Congenital primary aphakia (HP:0007707)	2.54466736
24	Hemiparesis (HP:0001269)	2.53292528
25	Focal motor seizures (HP:0011153)	2.48048697
26	Nephrogenic diabetes insipidus (HP:0009806)	2.47740211
27	Male pseudohermaphroditism (HP:0000037)	2.47002754
28	Septo-optic dysplasia (HP:0100842)	2.46665001
29	Abnormal drinking behavior (HP:0030082)	2.40266409
30	Polydipsia (HP:0001959)	2.40266409
31	Abnormal respiratory epithelium morphology (HP:0012253)	2.40034360
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.40034360
33	Broad-based gait (HP:0002136)	2.37248104
34	Acute necrotizing encephalopathy (HP:0006965)	2.34219561
35	Genital tract atresia (HP:0001827)	2.33845320
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.32082483
37	Absent/shortened dynein arms (HP:0200106)	2.32082483
38	Missing ribs (HP:0000921)	2.28761653
39	Febrile seizures (HP:0002373)	2.26282308
40	Abnormality of DNA repair (HP:0003254)	2.24446088
41	Abnormality of the diencephalon (HP:0010662)	2.23163624
42	Gastrointestinal atresia (HP:0002589)	2.17766384
43	Large for gestational age (HP:0001520)	2.17446151
44	Abnormal respiratory motile cilium physiology (HP:0012261)	2.16565778
45	Vaginal atresia (HP:0000148)	2.16545795
46	Hypoplastic ilia (HP:0000946)	2.14705031
47	Abnormality of the wing of the ilium (HP:0011867)	2.12651606
48	Sclerocornea (HP:0000647)	2.10956972
49	Conical tooth (HP:0000698)	2.08600771
50	Cystic liver disease (HP:0006706)	2.08454993
51	Severe muscular hypotonia (HP:0006829)	2.08302651
52	Acute encephalopathy (HP:0006846)	2.07446778
53	Atonic seizures (HP:0010819)	2.07192437
54	Optic nerve hypoplasia (HP:0000609)	2.06802796
55	Retinal atrophy (HP:0001105)	2.06527715
56	Congenital stationary night blindness (HP:0007642)	2.06490724
57	Renal cortical cysts (HP:0000803)	2.03000250
58	Congenital hepatic fibrosis (HP:0002612)	2.02033077
59	Protruding tongue (HP:0010808)	2.01775922
60	Progressive cerebellar ataxia (HP:0002073)	2.00495689
61	Progressive macrocephaly (HP:0004481)	1.99532403
62	Focal seizures (HP:0007359)	1.97297692
63	Abnormality of the labia minora (HP:0012880)	1.93230252
64	Retinal dysplasia (HP:0007973)	1.91507412
65	Abnormal rod and cone electroretinograms (HP:0008323)	1.89996750
66	Inability to walk (HP:0002540)	1.87938306
67	Morphological abnormality of the middle ear (HP:0008609)	1.87533253
68	Poor coordination (HP:0002370)	1.86894811
69	Lissencephaly (HP:0001339)	1.85737683
70	Gaze-evoked nystagmus (HP:0000640)	1.83839958
71	Concave nail (HP:0001598)	1.81658321
72	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81431831
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81070032
74	Intestinal atresia (HP:0011100)	1.78734612
75	Pachygyria (HP:0001302)	1.78677156
76	Mitochondrial inheritance (HP:0001427)	1.78401539
77	Increased CSF lactate (HP:0002490)	1.77716448
78	Esophageal atresia (HP:0002032)	1.77547895
79	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.76611675
80	Postaxial hand polydactyly (HP:0001162)	1.75686655
81	Attenuation of retinal blood vessels (HP:0007843)	1.74170751
82	Hip dysplasia (HP:0001385)	1.72975211
83	Abnormality of the pons (HP:0007361)	1.72389392
84	Median cleft lip (HP:0000161)	1.68297990
85	Specific learning disability (HP:0001328)	1.68254728
86	Hypoplasia of the pons (HP:0012110)	1.67919157
87	Oligodactyly (hands) (HP:0001180)	1.67780891
88	Tachypnea (HP:0002789)	1.66792770
89	Hepatic necrosis (HP:0002605)	1.66689873
90	Hepatocellular necrosis (HP:0001404)	1.65776932
91	Disproportionate short-trunk short stature (HP:0003521)	1.65402132
92	Anencephaly (HP:0002323)	1.65198560
93	Action tremor (HP:0002345)	1.64409459
94	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.63749442
95	Epileptiform EEG discharges (HP:0011182)	1.63142309
96	Duplicated collecting system (HP:0000081)	1.62835039
97	Tubulointerstitial abnormality (HP:0001969)	1.61969280
98	Pendular nystagmus (HP:0012043)	1.61558964
99	Midline defect of the nose (HP:0004122)	1.61201512
100	Aganglionic megacolon (HP:0002251)	1.60943772

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.75724524
2	WEE1	4.42134590
3	PINK1	3.43860760
4	TSSK6	3.43200647
5	IRAK1	3.00574898
6	FRK	2.79462799
7	TAOK3	2.70769688
8	CASK	2.53442196
9	TNIK	2.34698715
10	WNK4	2.21350464
11	WNK3	2.00207017
12	MAPK15	1.99837807
13	NTRK3	1.99305411
14	ZAK	1.99300243
15	STK39	1.92571884
16	NUAK1	1.87578966
17	MAPK13	1.80265660
18	NTRK2	1.72647662
19	PTK2B	1.68897574
20	ADRBK2	1.62751545
21	GRK1	1.54597284
22	MAPKAPK5	1.54019655
23	BRSK2	1.49239823
24	MKNK2	1.46144258
25	MARK1	1.25506009
26	PLK4	1.24773551
27	BMPR1B	1.24542254
28	DAPK2	1.23258891
29	PRKCG	1.19993649
30	CDK3	1.16009231
31	MAP3K4	1.15355533
32	NEK2	1.08819390
33	TIE1	1.06725861
34	UHMK1	1.02418155
35	TRIM28	0.97298180
36	DMPK	0.95639875
37	LATS1	0.94409758
38	PAK3	0.90792342
39	VRK1	0.87825028
40	BRSK1	0.85928436
41	PLK2	0.85241463
42	MAPKAPK3	0.81801014
43	PAK6	0.78714253
44	CCNB1	0.74254434
45	INSRR	0.73868334
46	OXSR1	0.70458927
47	MAP2K7	0.69357147
48	DYRK3	0.69051780
49	PKN1	0.66767626
50	PHKG2	0.66149048
51	PHKG1	0.66149048
52	PLK3	0.64620537
53	TAF1	0.64379025
54	STK3	0.63600083
55	EPHA4	0.62180803
56	MAP4K2	0.61580043
57	PRKCE	0.60847714
58	AKT3	0.59941468
59	PDK2	0.59186585
60	SIK2	0.58375072
61	MAP3K12	0.58327557
62	STK11	0.58062858
63	DYRK2	0.57810754
64	PLK1	0.57733922
65	WNK1	0.56619069
66	MELK	0.55230581
67	CAMKK2	0.53114978
68	CAMK1G	0.52116124
69	CAMK2A	0.51620527
70	ROCK1	0.51615692
71	EPHB2	0.49797131
72	FGFR2	0.48160795
73	ERBB2	0.47505408
74	MARK3	0.47343552
75	ADRBK1	0.46095637
76	TRPM7	0.45953832
77	NLK	0.45751750
78	CSNK1E	0.42735761
79	PRKG1	0.40536608
80	PRKACA	0.39921339
81	CAMK2D	0.35321356
82	SGK1	0.34716302
83	MKNK1	0.34212962
84	SGK2	0.33207840
85	PRKCQ	0.31747586
86	ERBB3	0.31047315
87	TTK	0.30216929
88	SGK223	0.29359275
89	SGK494	0.29359275
90	CDC7	0.29231449
91	CAMK2B	0.28109133
92	PRKD3	0.28078887
93	RPS6KA5	0.27952954
94	CSNK1A1	0.27863978
95	CAMK1	0.27745129
96	LATS2	0.27684130
97	NTRK1	0.26667785
98	EIF2AK2	0.25441411
99	CSNK1G2	0.24668670
100	TEC	0.24281771

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.06075225
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.93353848
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.69691705
4	Butanoate metabolism_Homo sapiens_hsa00650	2.60410306
5	Phototransduction_Homo sapiens_hsa04744	2.47391309
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32973096
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.26783390
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16667925
9	Morphine addiction_Homo sapiens_hsa05032	1.90787912
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.90026570
11	Circadian entrainment_Homo sapiens_hsa04713	1.89989250
12	Taste transduction_Homo sapiens_hsa04742	1.85633771
13	GABAergic synapse_Homo sapiens_hsa04727	1.85595650
14	Parkinsons disease_Homo sapiens_hsa05012	1.78863514
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.76420714
16	Olfactory transduction_Homo sapiens_hsa04740	1.75525834
17	Insulin secretion_Homo sapiens_hsa04911	1.74015091
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.70824366
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69940904
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.68505907
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.63138853
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.58839927
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52743753
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.51201638
25	Homologous recombination_Homo sapiens_hsa03440	1.49179677
26	Amphetamine addiction_Homo sapiens_hsa05031	1.48812399
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43700313
28	Protein export_Homo sapiens_hsa03060	1.38539368
29	Cocaine addiction_Homo sapiens_hsa05030	1.38126533
30	Alzheimers disease_Homo sapiens_hsa05010	1.34675275
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.34539758
32	Dopaminergic synapse_Homo sapiens_hsa04728	1.29805035
33	Regulation of autophagy_Homo sapiens_hsa04140	1.29431037
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28875005
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28863078
36	Huntingtons disease_Homo sapiens_hsa05016	1.27559121
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25850059
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22780081
39	Serotonergic synapse_Homo sapiens_hsa04726	1.21032049
40	Propanoate metabolism_Homo sapiens_hsa00640	1.15665556
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.15437400
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09622523
43	Basal transcription factors_Homo sapiens_hsa03022	1.08825974
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06397925
45	Peroxisome_Homo sapiens_hsa04146	1.05663574
46	Salivary secretion_Homo sapiens_hsa04970	1.04661385
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.03611381
48	Calcium signaling pathway_Homo sapiens_hsa04020	1.00405122
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98638279
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.98608618
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.93240282
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92602457
53	Caffeine metabolism_Homo sapiens_hsa00232	0.88666158
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85973756
55	Cholinergic synapse_Homo sapiens_hsa04725	0.85906196
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.85837771
57	Renin secretion_Homo sapiens_hsa04924	0.84702904
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.84509305
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83813188
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83626838
61	ABC transporters_Homo sapiens_hsa02010	0.83147626
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.76763161
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75707345
64	Axon guidance_Homo sapiens_hsa04360	0.72498758
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.71975253
66	Mineral absorption_Homo sapiens_hsa04978	0.71845835
67	RNA degradation_Homo sapiens_hsa03018	0.71257916
68	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.69565871
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.69384016
70	Gastric acid secretion_Homo sapiens_hsa04971	0.67163927
71	Ribosome_Homo sapiens_hsa03010	0.65975422
72	Retinol metabolism_Homo sapiens_hsa00830	0.65744204
73	Estrogen signaling pathway_Homo sapiens_hsa04915	0.63787591
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63610223
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58896281
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58799303
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58613138
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.58040225
79	Long-term depression_Homo sapiens_hsa04730	0.55624549
80	Oocyte meiosis_Homo sapiens_hsa04114	0.54680385
81	Folate biosynthesis_Homo sapiens_hsa00790	0.53738812
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51484914
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51339920
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51268029
85	PPAR signaling pathway_Homo sapiens_hsa03320	0.50869786
86	Pancreatic secretion_Homo sapiens_hsa04972	0.50591498
87	Alcoholism_Homo sapiens_hsa05034	0.49330707
88	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48052599
89	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47930380
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.46043086
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46023398
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45228092
93	Gap junction_Homo sapiens_hsa04540	0.45146189
94	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43720647
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43596354
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.42502035
97	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.42211044
98	Metabolic pathways_Homo sapiens_hsa01100	0.41686762
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.40248979
100	Sulfur relay system_Homo sapiens_hsa04122	0.39108148

ANKRD20A1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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