ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.04295217
2	fusion of sperm to egg plasma membrane (GO:0007342)	8.09688716
3	acrosome reaction (GO:0007340)	7.20694072
4	protein polyglutamylation (GO:0018095)	7.05763034
5	establishment of protein localization to Golgi (GO:0072600)	6.90040596
6	protein targeting to Golgi (GO:0000042)	6.79295376
7	microtubule depolymerization (GO:0007019)	6.36774475
8	microtubule polymerization or depolymerization (GO:0031109)	6.25557894
9	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.23009911
10	plasma membrane fusion (GO:0045026)	6.13495312
11	axonemal dynein complex assembly (GO:0070286)	5.94980833
12	spermatid development (GO:0007286)	5.89485222
13	centriole replication (GO:0007099)	5.88605029
14	chromosome condensation (GO:0030261)	5.78563809
15	multicellular organism reproduction (GO:0032504)	5.67463685
16	response to pheromone (GO:0019236)	5.61037135
17	cell wall macromolecule catabolic process (GO:0016998)	5.58219657
18	DNA packaging (GO:0006323)	5.54260329
19	sperm-egg recognition (GO:0035036)	5.27724092
20	sperm capacitation (GO:0048240)	5.15778814
21	spermatogenesis (GO:0007283)	5.07501197
22	male gamete generation (GO:0048232)	5.06575159
23	protein localization to Golgi apparatus (GO:0034067)	4.96775612
24	centriole assembly (GO:0098534)	4.92921615
25	cell wall macromolecule metabolic process (GO:0044036)	4.90686592
26	musculoskeletal movement (GO:0050881)	4.83148949
27	multicellular organismal movement (GO:0050879)	4.83148949
28	positive regulation of guanylate cyclase activity (GO:0031284)	4.79829649
29	reproduction (GO:0000003)	4.73887318
30	calcium ion-dependent exocytosis (GO:0017156)	4.69764457
31	gamete generation (GO:0007276)	4.67737366
32	seminiferous tubule development (GO:0072520)	4.64979717
33	atrial cardiac muscle cell action potential (GO:0086014)	4.49122505
34	rRNA methylation (GO:0031167)	4.37167356
35	binding of sperm to zona pellucida (GO:0007339)	4.35209311
36	regulation of guanylate cyclase activity (GO:0031282)	4.34869824
37	spermatid nucleus differentiation (GO:0007289)	4.33428351
38	cell-cell recognition (GO:0009988)	4.32300916
39	cellular ketone body metabolic process (GO:0046950)	4.31520719
40	epithelial cilium movement (GO:0003351)	4.31027850
41	single fertilization (GO:0007338)	4.29070676
42	regulation of centriole replication (GO:0046599)	4.28110947
43	glomerular visceral epithelial cell development (GO:0072015)	4.24510648
44	regulation of microtubule-based movement (GO:0060632)	4.16935168
45	tRNA methylation (GO:0030488)	4.14468068
46	negative regulation of organelle assembly (GO:1902116)	4.14319688
47	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.13039423
48	regulation of cilium movement (GO:0003352)	4.11477834
49	fertilization (GO:0009566)	4.09939780
50	cilium or flagellum-dependent cell motility (GO:0001539)	4.09858704
51	pericardium development (GO:0060039)	4.05737908
52	cilium movement (GO:0003341)	3.98816825
53	microtubule severing (GO:0051013)	3.96948070
54	single strand break repair (GO:0000012)	3.96464837
55	glomerular epithelial cell development (GO:0072310)	3.95472074
56	regulation of Rab GTPase activity (GO:0032313)	3.83686154
57	positive regulation of Rab GTPase activity (GO:0032851)	3.83686154
58	ketone body metabolic process (GO:1902224)	3.77853073
59	phosphatidylethanolamine metabolic process (GO:0046337)	3.75002075
60	multicellular organismal reproductive process (GO:0048609)	3.66846468
61	microtubule nucleation (GO:0007020)	3.64425680
62	motile cilium assembly (GO:0044458)	3.52558836
63	postsynaptic membrane organization (GO:0001941)	3.52152238
64	male sex determination (GO:0030238)	3.51458835
65	piRNA metabolic process (GO:0034587)	3.49387229
66	urinary tract smooth muscle contraction (GO:0014848)	3.49361129
67	negative regulation of inclusion body assembly (GO:0090084)	3.43563025
68	germ cell development (GO:0007281)	3.41249469
69	rRNA modification (GO:0000154)	3.39781013
70	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.38409378
71	regulation of meiosis I (GO:0060631)	3.35011332
72	peristalsis (GO:0030432)	3.29677367
73	axoneme assembly (GO:0035082)	3.27796820
74	RNA destabilization (GO:0050779)	3.27352740
75	presynaptic membrane assembly (GO:0097105)	3.24212224
76	vesicle transport along microtubule (GO:0047496)	3.19053101
77	mitotic G1 DNA damage checkpoint (GO:0031571)	3.17694173
78	nuclear pore complex assembly (GO:0051292)	3.10035985
79	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.09859124
80	appendage development (GO:0048736)	2.97492271
81	limb development (GO:0060173)	2.97492271
82	protein K48-linked deubiquitination (GO:0071108)	2.95723021
83	membrane protein intracellular domain proteolysis (GO:0031293)	2.95206411
84	sexual reproduction (GO:0019953)	2.92861124
85	polarized epithelial cell differentiation (GO:0030859)	2.92075847
86	cardiovascular system development (GO:0072358)	2.91804700
87	positive regulation of cGMP biosynthetic process (GO:0030828)	2.91729455
88	DNA methylation involved in gamete generation (GO:0043046)	2.91080608
89	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.85685986
90	myotube differentiation (GO:0014902)	2.85213163
91	organic cation transport (GO:0015695)	2.82467141
92	G1 DNA damage checkpoint (GO:0044783)	2.80427617
93	lysine catabolic process (GO:0006554)	2.79681910
94	lysine metabolic process (GO:0006553)	2.79681910
95	ventricular system development (GO:0021591)	2.79555721
96	mitotic G1/S transition checkpoint (GO:0044819)	2.79065296
97	arginine catabolic process (GO:0006527)	2.77736341
98	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.74053346
99	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.74053346
100	regulation of mesoderm development (GO:2000380)	2.73281035

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.33664435
2	VDR_22108803_ChIP-Seq_LS180_Human	3.31849855
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.27164661
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.21235095
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.09705719
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.88736482
7	FUS_26573619_Chip-Seq_HEK293_Human	2.81448521
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61767153
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.61767153
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48709519
11	GATA1_22025678_ChIP-Seq_K562_Human	2.14094193
12	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	2.08457133
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08063323
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.01093395
15	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.00884027
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.93379642
17	P300_19829295_ChIP-Seq_ESCs_Human	1.91787903
18	CBP_20019798_ChIP-Seq_JUKART_Human	1.86618100
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.86618100
20	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.80277947
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.77444985
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.76547504
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.72628230
24	MYC_19829295_ChIP-Seq_ESCs_Human	1.72279617
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.71643049
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.70400051
27	DROSHA_22980978_ChIP-Seq_HELA_Human	1.69199511
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64675662
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.64374728
30	AR_25329375_ChIP-Seq_VCAP_Human	1.61048117
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58188314
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56561965
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.56218290
34	STAT3_23295773_ChIP-Seq_U87_Human	1.55801313
35	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.51873968
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51805862
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46568626
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43363808
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.42368517
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40350067
41	ERA_21632823_ChIP-Seq_H3396_Human	1.39932277
42	RUNX2_22187159_ChIP-Seq_PCA_Human	1.38792814
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.37605576
44	TCF4_23295773_ChIP-Seq_U87_Human	1.36949965
45	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.34300275
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33269463
47	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.31426134
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28815859
49	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.26757616
50	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.25662168
51	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24953974
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24838055
53	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.24719698
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24452308
55	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.22916770
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.21648461
57	CJUN_26792858_Chip-Seq_BT549_Human	1.21141306
58	ETV1_20927104_ChIP-Seq_GIST48_Human	1.20606916
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20520437
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.20043880
61	RBPJ_21746931_ChIP-Seq_IB4_Human	1.19539410
62	TBL1_22424771_ChIP-Seq_293T_Human	1.19064167
63	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.17706987
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17462183
65	KDM2B_26808549_Chip-Seq_REH_Human	1.16316685
66	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15891605
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.15364561
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14262296
69	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.13991453
70	AR_19668381_ChIP-Seq_PC3_Human	1.13911782
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.12902567
72	AHR_22903824_ChIP-Seq_MCF-7_Human	1.11742979
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11521559
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11194697
75	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.11015937
76	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.10678338
77	NFYB_21822215_ChIP-Seq_K562_Human	1.10552872
78	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.09744063
79	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.09609696
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09071399
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08814985
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08371398
83	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08329274
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08329274
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07867996
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07867996
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07067586
88	P53_21459846_ChIP-Seq_SAOS-2_Human	1.06535460
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05457079
90	TP53_18474530_ChIP-ChIP_U2OS_Human	1.05329224
91	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05206957
92	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05075420
93	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.05025170
94	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.04270240
95	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.03187020
96	OCT4_20526341_ChIP-Seq_ESCs_Human	1.02776154
97	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.02179293
98	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.01486935
99	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00891327
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.99633725

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.30166916
2	MP0000566_synostosis	5.73326382
3	MP0001348_abnormal_lacrimal_gland	4.84406706
4	MP0003646_muscle_fatigue	3.86681295
5	MP0005377_hearing/vestibular/ear_phenot	3.84237317
6	MP0003878_abnormal_ear_physiology	3.84237317
7	MP0003698_abnormal_male_reproductive	2.90096025
8	MP0005670_abnormal_white_adipose	2.85809426
9	MP0005167_abnormal_blood-brain_barrier	2.83930062
10	MP0003718_maternal_effect	2.49123546
11	MP0001929_abnormal_gametogenesis	2.46873167
12	MP0002735_abnormal_chemical_nociception	2.14648813
13	MP0009697_abnormal_copulation	2.09092632
14	MP0001486_abnormal_startle_reflex	2.06096469
15	MP0004147_increased_porphyrin_level	1.96589736
16	MP0005645_abnormal_hypothalamus_physiol	1.76771761
17	MP0001485_abnormal_pinna_reflex	1.69987125
18	MP0005310_abnormal_salivary_gland	1.59091224
19	MP0003011_delayed_dark_adaptation	1.55219134
20	MP0002210_abnormal_sex_determination	1.51928572
21	MP0001984_abnormal_olfaction	1.48954056
22	MP0004859_abnormal_synaptic_plasticity	1.46344335
23	MP0003693_abnormal_embryo_hatching	1.44462997
24	MP0002161_abnormal_fertility/fecundity	1.42079791
25	MP0005551_abnormal_eye_electrophysiolog	1.40846823
26	MP0001501_abnormal_sleep_pattern	1.39039124
27	MP0005253_abnormal_eye_physiology	1.37942389
28	MP0000383_abnormal_hair_follicle	1.32443234
29	MP0003137_abnormal_impulse_conducting	1.29238117
30	MP0008057_abnormal_DNA_replication	1.28629953
31	MP0001963_abnormal_hearing_physiology	1.28502761
32	MP0000049_abnormal_middle_ear	1.28094863
33	MP0002102_abnormal_ear_morphology	1.25001661
34	MP0002733_abnormal_thermal_nociception	1.21329771
35	MP0008569_lethality_at_weaning	1.21023354
36	MP0008872_abnormal_physiological_respon	1.18224287
37	MP0009115_abnormal_fat_cell	1.16301010
38	MP0008789_abnormal_olfactory_epithelium	1.16045094
39	MP0000428_abnormal_craniofacial_morphol	1.15196948
40	MP0009745_abnormal_behavioral_response	1.14373585
41	MP0008877_abnormal_DNA_methylation	1.12698611
42	MP0004742_abnormal_vestibular_system	1.12240827
43	MP0002272_abnormal_nervous_system	1.11251808
44	MP0000230_abnormal_systemic_arterial	1.10683666
45	MP0002557_abnormal_social/conspecific_i	1.09838609
46	MP0001145_abnormal_male_reproductive	1.09072169
47	MP0005379_endocrine/exocrine_gland_phen	1.09020751
48	MP0003879_abnormal_hair_cell	1.07565992
49	MP0004084_abnormal_cardiac_muscle	1.05549775
50	MP0001970_abnormal_pain_threshold	1.04385948
51	MP0005395_other_phenotype	1.02590601
52	MP0004036_abnormal_muscle_relaxation	1.02423825
53	MP0000653_abnormal_sex_gland	1.01544520
54	MP0008961_abnormal_basal_metabolism	1.00857948
55	MP0002938_white_spotting	0.99998740
56	MP0009053_abnormal_anal_canal	0.98418147
57	MP0000026_abnormal_inner_ear	0.97388234
58	MP0004085_abnormal_heartbeat	0.96322439
59	MP0009046_muscle_twitch	0.95633525
60	MP0004782_abnormal_surfactant_physiolog	0.93943959
61	MP0000678_abnormal_parathyroid_gland	0.92360530
62	MP0005646_abnormal_pituitary_gland	0.91342634
63	MP0003635_abnormal_synaptic_transmissio	0.91037916
64	MP0001299_abnormal_eye_distance/	0.88043053
65	MP0005394_taste/olfaction_phenotype	0.87685827
66	MP0005499_abnormal_olfactory_system	0.87685827
67	MP0002067_abnormal_sensory_capabilities	0.87518241
68	MP0002254_reproductive_system_inflammat	0.83967895
69	MP0000372_irregular_coat_pigmentation	0.83663400
70	MP0002064_seizures	0.83336799
71	MP0000534_abnormal_ureter_morphology	0.82379560
72	MP0002734_abnormal_mechanical_nocicepti	0.82282161
73	MP0003937_abnormal_limbs/digits/tail_de	0.81263303
74	MP0002653_abnormal_ependyma_morphology	0.81032364
75	MP0001968_abnormal_touch/_nociception	0.80099910
76	MP0005391_vision/eye_phenotype	0.78858887
77	MP0002822_catalepsy	0.78027519
78	MP0002184_abnormal_innervation	0.77847530
79	MP0002282_abnormal_trachea_morphology	0.77290769
80	MP0001765_abnormal_ion_homeostasis	0.76565020
81	MP0003119_abnormal_digestive_system	0.76040081
82	MP0006276_abnormal_autonomic_nervous	0.75191538
83	MP0002736_abnormal_nociception_after	0.74865312
84	MP0000427_abnormal_hair_cycle	0.72350668
85	MP0002572_abnormal_emotion/affect_behav	0.71623265
86	MP0010329_abnormal_lipoprotein_level	0.69334379
87	MP0000955_abnormal_spinal_cord	0.66792068
88	MP0004043_abnormal_pH_regulation	0.66609011
89	MP0005423_abnormal_somatic_nervous	0.66482776
90	MP0005266_abnormal_metabolism	0.66354053
91	MP0010678_abnormal_skin_adnexa	0.66051901
92	MP0002063_abnormal_learning/memory/cond	0.65448219
93	MP0002332_abnormal_exercise_endurance	0.62749714
94	MP0004885_abnormal_endolymph	0.60924796
95	MP0002127_abnormal_cardiovascular_syste	0.59255551
96	MP0006292_abnormal_olfactory_placode	0.59116225
97	MP0002098_abnormal_vibrissa_morphology	0.57197954
98	MP0005666_abnormal_adipose_tissue	0.57078192
99	MP0008775_abnormal_heart_ventricle	0.56997839
100	MP0005451_abnormal_body_composition	0.56985894

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	6.41733409
2	Birth length less than 3rd percentile (HP:0003561)	6.33420527
3	Tubulointerstitial nephritis (HP:0001970)	5.28489379
4	Breast hypoplasia (HP:0003187)	4.79312338
5	Intestinal atresia (HP:0011100)	4.68947225
6	Severe visual impairment (HP:0001141)	4.68934813
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.27850752
8	Absent/shortened dynein arms (HP:0200106)	4.27850752
9	Abnormal ciliary motility (HP:0012262)	3.81234353
10	Nephronophthisis (HP:0000090)	3.69924726
11	Abnormal respiratory epithelium morphology (HP:0012253)	3.64214823
12	Abnormal respiratory motile cilium morphology (HP:0005938)	3.64214823
13	Abnormal respiratory motile cilium physiology (HP:0012261)	3.59100810
14	Myokymia (HP:0002411)	3.51759536
15	Bony spicule pigmentary retinopathy (HP:0007737)	3.47152897
16	Cone-rod dystrophy (HP:0000548)	3.36261527
17	Attenuation of retinal blood vessels (HP:0007843)	3.35914976
18	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.34239156
19	Abnormality of the renal medulla (HP:0100957)	3.07785801
20	Aplasia/Hypoplasia of the sternum (HP:0006714)	3.04170364
21	Abnormality of lateral ventricle (HP:0030047)	3.02781057
22	Abnormality of the aortic arch (HP:0012303)	3.00527529
23	Pancreatic cysts (HP:0001737)	2.95501108
24	Gastrointestinal atresia (HP:0002589)	2.91246892
25	Tubulointerstitial abnormality (HP:0001969)	2.89840590
26	Subaortic stenosis (HP:0001682)	2.89258341
27	Abnormality of the left ventricular outflow tract (HP:0011103)	2.89258341
28	Asymmetric septal hypertrophy (HP:0001670)	2.85672626
29	Type II lissencephaly (HP:0007260)	2.85095274
30	Amelogenesis imperfecta (HP:0000705)	2.84097667
31	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.76459838
32	Depressed nasal tip (HP:0000437)	2.71462000
33	Focal segmental glomerulosclerosis (HP:0000097)	2.69737884
34	Impulsivity (HP:0100710)	2.68167567
35	Microretrognathia (HP:0000308)	2.65630055
36	Growth hormone deficiency (HP:0000824)	2.65327360
37	Renovascular hypertension (HP:0100817)	2.63171962
38	Stage 5 chronic kidney disease (HP:0003774)	2.60502879
39	Diastasis recti (HP:0001540)	2.59484214
40	Pancreatic fibrosis (HP:0100732)	2.55631141
41	Tubular atrophy (HP:0000092)	2.54514935
42	Pendular nystagmus (HP:0012043)	2.53531370
43	Abnormality of the fingertips (HP:0001211)	2.53034574
44	True hermaphroditism (HP:0010459)	2.42380181
45	Polydipsia (HP:0001959)	2.41824683
46	Abnormal drinking behavior (HP:0030082)	2.41824683
47	Hyperkalemia (HP:0002153)	2.40946442
48	Patellar aplasia (HP:0006443)	2.40731098
49	Progressive sensorineural hearing impairment (HP:0000408)	2.40017769
50	Intellectual disability, moderate (HP:0002342)	2.36903917
51	Recurrent pneumonia (HP:0006532)	2.34645754
52	Abnormality of midbrain morphology (HP:0002418)	2.34243087
53	Molar tooth sign on MRI (HP:0002419)	2.34243087
54	Hypoalphalipoproteinemia (HP:0003233)	2.31190215
55	Truncal obesity (HP:0001956)	2.29581767
56	Abnormality of macular pigmentation (HP:0008002)	2.27471948
57	Glomerulosclerosis (HP:0000096)	2.27238733
58	Rhabdomyosarcoma (HP:0002859)	2.26751527
59	Rhinitis (HP:0012384)	2.25222452
60	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.23451327
61	Progressive cerebellar ataxia (HP:0002073)	2.23051592
62	Male infertility (HP:0003251)	2.22891788
63	Menstrual irregularities (HP:0000858)	2.22717825
64	Widely spaced teeth (HP:0000687)	2.22360547
65	Cystic liver disease (HP:0006706)	2.20135688
66	Abnormality of dental color (HP:0011073)	2.16545082
67	Aplasia/Hypoplasia of the patella (HP:0006498)	2.16452027
68	Chin dimple (HP:0010751)	2.16345068
69	Infertility (HP:0000789)	2.14271872
70	Mesangial abnormality (HP:0001966)	2.08609141
71	Cerebellar dysplasia (HP:0007033)	2.08327044
72	Sleep apnea (HP:0010535)	2.07891875
73	Resting tremor (HP:0002322)	2.07258577
74	Abnormality of the renal cortex (HP:0011035)	2.07069014
75	Anencephaly (HP:0002323)	2.06600820
76	Hyperventilation (HP:0002883)	2.06393861
77	Nasal polyposis (HP:0100582)	2.01663565
78	Short ribs (HP:0000773)	2.01323780
79	Abnormal urine output (HP:0012590)	2.01021876
80	Hypoplastic ischia (HP:0003175)	2.00851701
81	Long foot (HP:0001833)	1.98050704
82	Polyuria (HP:0000103)	1.96672421
83	Portal hypertension (HP:0001409)	1.96302474
84	Chorioretinal atrophy (HP:0000533)	1.95104293
85	Protruding tongue (HP:0010808)	1.94665734
86	Optic nerve hypoplasia (HP:0000609)	1.94205640
87	Esophageal atresia (HP:0002032)	1.91965873
88	Epidermoid cyst (HP:0200040)	1.91219609
89	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.90260642
90	Abnormal rod and cone electroretinograms (HP:0008323)	1.88515444
91	Lissencephaly (HP:0001339)	1.88433658
92	Ependymoma (HP:0002888)	1.86493003
93	Decreased central vision (HP:0007663)	1.85035835
94	Astrocytoma (HP:0009592)	1.83960746
95	Abnormality of the astrocytes (HP:0100707)	1.83960746
96	Congenital stationary night blindness (HP:0007642)	1.82372694
97	Postural instability (HP:0002172)	1.79565791
98	Abnormality of the hepatic vasculature (HP:0006707)	1.78439491
99	Abnormality of the ischium (HP:0003174)	1.76641679
100	Scotoma (HP:0000575)	1.73815622

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	6.00689993
2	ACVR1B	5.80946732
3	STK16	5.35097832
4	BMPR1B	4.84975515
5	MAP4K2	3.64374619
6	INSRR	3.38587431
7	BRD4	3.20348680
8	FRK	3.07761980
9	TGFBR1	2.63823475
10	DAPK2	2.37984979
11	PLK2	2.30830742
12	NME1	2.28286115
13	CASK	2.03191121
14	STK38L	2.01945902
15	PIK3CG	1.98498365
16	CAMK1G	1.86084040
17	PNCK	1.80006195
18	TESK1	1.47975853
19	MAP3K7	1.46740105
20	PTK2B	1.40813549
21	MAP2K1	1.36209579
22	PRKD3	1.33396124
23	STK38	1.29115838
24	MELK	1.25461987
25	NTRK3	1.23121192
26	DDR2	1.16313274
27	CAMKK1	1.04108911
28	CAMK1D	1.03022100
29	ZAK	0.98099790
30	PDK1	0.97887978
31	TYRO3	0.96475624
32	VRK1	0.87262548
33	CAMK4	0.82096908
34	NEK6	0.77334785
35	AKT3	0.77017535
36	MKNK2	0.76988495
37	ADRBK2	0.75251597
38	CDK12	0.72580085
39	MARK1	0.72195533
40	MST1R	0.71319787
41	CAMK1	0.69652602
42	MAPK15	0.69122931
43	MAP3K13	0.68677443
44	PDPK1	0.68350654
45	TIE1	0.66617680
46	ADRBK1	0.66250268
47	WEE1	0.63574178
48	CDK7	0.62376773
49	SRPK1	0.62063083
50	NEK9	0.61155634
51	PRKG2	0.57591721
52	SIK2	0.56141119
53	WNK1	0.55537235
54	MAP3K4	0.55293114
55	MET	0.51046887
56	MAP2K2	0.46000235
57	MAP2K7	0.41494397
58	PRKG1	0.41444332
59	PRKCZ	0.40925161
60	PRKCG	0.40209385
61	MST4	0.39783937
62	CAMK2A	0.39585209
63	PRKAA2	0.37920996
64	FGR	0.36056240
65	CHUK	0.36039648
66	WNK4	0.35733593
67	SGK2	0.34862537
68	TAF1	0.31211928
69	SGK223	0.29108524
70	SGK494	0.29108524
71	NEK2	0.27325553
72	PRKCE	0.27060245
73	FLT3	0.26283738
74	IGF1R	0.25753101
75	GRK7	0.25431383
76	MAPK1	0.24875982
77	CDK1	0.24425956
78	BRSK2	0.23485999
79	PRKCQ	0.21347957
80	BRSK1	0.21267454
81	ERBB3	0.20725564
82	CAMKK2	0.20115501
83	CDK3	0.19158109
84	GSK3B	0.18155442
85	GRK5	0.17698925
86	MAP2K6	0.16364292
87	BRAF	0.16336725
88	CDK2	0.15341857
89	ROCK1	0.15247172
90	GRK1	0.14980507
91	RPS6KA6	0.14554869
92	STK39	0.13927459
93	MAPK13	0.13472125
94	CSF1R	0.12046207
95	AKT1	0.11367319
96	RET	0.10308488
97	PRKACA	0.10272484
98	CHEK1	0.10220069
99	TNK2	0.09868837
100	TAOK3	0.09357696

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.65075600
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.57769465
3	ABC transporters_Homo sapiens_hsa02010	2.71871290
4	Olfactory transduction_Homo sapiens_hsa04740	2.60884021
5	Butanoate metabolism_Homo sapiens_hsa00650	2.44853856
6	Fatty acid degradation_Homo sapiens_hsa00071	2.11950308
7	Nicotine addiction_Homo sapiens_hsa05033	1.98643998
8	Nitrogen metabolism_Homo sapiens_hsa00910	1.94600577
9	Phototransduction_Homo sapiens_hsa04744	1.92741812
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.91494225
11	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.66822099
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.61482818
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.55089714
14	Serotonergic synapse_Homo sapiens_hsa04726	1.51270003
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.49761881
16	Salivary secretion_Homo sapiens_hsa04970	1.49596910
17	Glutamatergic synapse_Homo sapiens_hsa04724	1.45874818
18	RNA transport_Homo sapiens_hsa03013	1.44882346
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.38716792
20	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.37754235
21	Insulin secretion_Homo sapiens_hsa04911	1.37595371
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.32545419
23	Calcium signaling pathway_Homo sapiens_hsa04020	1.32242783
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29705212
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.28975454
26	Taste transduction_Homo sapiens_hsa04742	1.28467661
27	Histidine metabolism_Homo sapiens_hsa00340	1.28296300
28	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.26868817
29	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.24162236
30	Glycerolipid metabolism_Homo sapiens_hsa00561	1.24153655
31	Gastric acid secretion_Homo sapiens_hsa04971	1.15849051
32	Long-term depression_Homo sapiens_hsa04730	1.13802141
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.12052579
34	Tyrosine metabolism_Homo sapiens_hsa00350	1.11787638
35	Morphine addiction_Homo sapiens_hsa05032	1.08713571
36	Arginine and proline metabolism_Homo sapiens_hsa00330	1.06729136
37	Retinol metabolism_Homo sapiens_hsa00830	1.06067612
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.05342784
39	Circadian entrainment_Homo sapiens_hsa04713	1.01885090
40	GABAergic synapse_Homo sapiens_hsa04727	1.01879888
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00366873
42	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.95681616
43	PPAR signaling pathway_Homo sapiens_hsa03320	0.94394932
44	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.93013695
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.91956689
46	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.91638019
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90562678
48	cAMP signaling pathway_Homo sapiens_hsa04024	0.89521382
49	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.87332304
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.87033846
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83451615
52	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.81801804
53	VEGF signaling pathway_Homo sapiens_hsa04370	0.78428409
54	Renin secretion_Homo sapiens_hsa04924	0.77533663
55	Pancreatic secretion_Homo sapiens_hsa04972	0.76120232
56	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.73128060
57	Type II diabetes mellitus_Homo sapiens_hsa04930	0.72858177
58	Bile secretion_Homo sapiens_hsa04976	0.71207834
59	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.70811206
60	Lysine degradation_Homo sapiens_hsa00310	0.70144807
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67809848
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66446560
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.66290467
64	Phenylalanine metabolism_Homo sapiens_hsa00360	0.65929128
65	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64276150
66	Long-term potentiation_Homo sapiens_hsa04720	0.63700172
67	Amphetamine addiction_Homo sapiens_hsa05031	0.60751395
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56569712
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.55631635
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53201826
71	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.51197830
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.50408622
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49703080
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49328465
75	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.48892824
76	Wnt signaling pathway_Homo sapiens_hsa04310	0.48467337
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46732732
78	Cell cycle_Homo sapiens_hsa04110	0.44382424
79	Oocyte meiosis_Homo sapiens_hsa04114	0.43098177
80	Cholinergic synapse_Homo sapiens_hsa04725	0.42903511
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42864220
82	African trypanosomiasis_Homo sapiens_hsa05143	0.42291995
83	Propanoate metabolism_Homo sapiens_hsa00640	0.39795896
84	Sulfur relay system_Homo sapiens_hsa04122	0.38515340
85	mRNA surveillance pathway_Homo sapiens_hsa03015	0.38003925
86	Axon guidance_Homo sapiens_hsa04360	0.37921600
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35362176
88	Base excision repair_Homo sapiens_hsa03410	0.33298594
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.32972594
90	FoxO signaling pathway_Homo sapiens_hsa04068	0.32867749
91	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.31179262
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30417239
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.30196343
94	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.28033215
95	Estrogen signaling pathway_Homo sapiens_hsa04915	0.27646548
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.27363747
97	Mineral absorption_Homo sapiens_hsa04978	0.27325185
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.26269709
99	Choline metabolism in cancer_Homo sapiens_hsa05231	0.26082627
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.25353613

ANKRD20A10P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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