ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of protein glycosylation (GO:0060049)	5.04390442
2	negative regulation of systemic arterial blood pressure (GO:0003085)	4.83899305
3	L-fucose metabolic process (GO:0042354)	4.74919638
4	L-fucose catabolic process (GO:0042355)	4.74919638
5	fucose catabolic process (GO:0019317)	4.74919638
6	establishment of protein localization to Golgi (GO:0072600)	4.71681224
7	regulation of establishment of cell polarity (GO:2000114)	4.35097153
8	adaptation of signaling pathway (GO:0023058)	4.21971776
9	centriole replication (GO:0007099)	4.16715968
10	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.84812765
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.83208456
12	protein targeting to lysosome (GO:0006622)	3.79505633
13	establishment of protein localization to vacuole (GO:0072666)	3.79505633
14	protein targeting to vacuole (GO:0006623)	3.79505633
15	protein targeting to Golgi (GO:0000042)	3.75340371
16	intra-S DNA damage checkpoint (GO:0031573)	3.72625884
17	snRNA transcription (GO:0009301)	3.71590413
18	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.60072144
19	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.52620393
20	regulation of acrosome reaction (GO:0060046)	3.38885653
21	double-strand break repair via homologous recombination (GO:0000724)	3.30118897
22	recombinational repair (GO:0000725)	3.25097957
23	axon ensheathment in central nervous system (GO:0032291)	3.21811359
24	central nervous system myelination (GO:0022010)	3.21811359
25	indole-containing compound catabolic process (GO:0042436)	3.19802446
26	indolalkylamine catabolic process (GO:0046218)	3.19802446
27	tryptophan catabolic process (GO:0006569)	3.19802446
28	protein localization to Golgi apparatus (GO:0034067)	3.18680792
29	reciprocal DNA recombination (GO:0035825)	3.13944258
30	reciprocal meiotic recombination (GO:0007131)	3.13944258
31	male meiosis (GO:0007140)	3.12912675
32	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	3.12404349
33	TOR signaling (GO:0031929)	3.12277364
34	auditory receptor cell differentiation (GO:0042491)	3.12244384
35	cellular response to interleukin-15 (GO:0071350)	3.11939216
36	cellular response to gamma radiation (GO:0071480)	3.08948067
37	ketone body metabolic process (GO:1902224)	3.05894878
38	monoubiquitinated protein deubiquitination (GO:0035520)	3.04775633
39	protein K48-linked deubiquitination (GO:0071108)	3.04130013
40	cellular ketone body metabolic process (GO:0046950)	3.03069140
41	protein K63-linked deubiquitination (GO:0070536)	2.99761775
42	sperm motility (GO:0030317)	2.97724242
43	sulfation (GO:0051923)	2.97148496
44	axoneme assembly (GO:0035082)	2.96659398
45	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.96167639
46	replication fork processing (GO:0031297)	2.95100919
47	centriole assembly (GO:0098534)	2.93917460
48	meiotic chromosome segregation (GO:0045132)	2.93654751
49	positive regulation of developmental pigmentation (GO:0048087)	2.90245617
50	multicellular organism reproduction (GO:0032504)	2.89381857
51	DNA double-strand break processing (GO:0000729)	2.85513619
52	histone H3-K9 modification (GO:0061647)	2.84006919
53	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.82708989
54	regulation of DNA endoreduplication (GO:0032875)	2.77144686
55	kynurenine metabolic process (GO:0070189)	2.76875818
56	protein localization to vacuole (GO:0072665)	2.76106617
57	protein localization to lysosome (GO:0061462)	2.76106617
58	histone H3-K9 methylation (GO:0051567)	2.76027140
59	DNA methylation involved in gamete generation (GO:0043046)	2.75139362
60	keratinocyte development (GO:0003334)	2.73045262
61	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.71624197
62	methionine biosynthetic process (GO:0009086)	2.71047570
63	tryptophan metabolic process (GO:0006568)	2.69194297
64	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.68886354
65	negative regulation of protein localization to cell surface (GO:2000009)	2.68147565
66	piRNA metabolic process (GO:0034587)	2.67368704
67	centrosome organization (GO:0051297)	2.66435435
68	microtubule organizing center organization (GO:0031023)	2.64056442
69	fusion of sperm to egg plasma membrane (GO:0007342)	2.62662226
70	regulation of centriole replication (GO:0046599)	2.62301113
71	indolalkylamine metabolic process (GO:0006586)	2.61014984
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.60446097
73	phosphatidylethanolamine metabolic process (GO:0046337)	2.59037864
74	rRNA methylation (GO:0031167)	2.56085070
75	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.55046361
76	sleep (GO:0030431)	2.54468819
77	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.53230304
78	male meiosis I (GO:0007141)	2.51460878
79	negative regulation of multicellular organism growth (GO:0040015)	2.51012511
80	cilium morphogenesis (GO:0060271)	2.50012833
81	positive regulation of action potential (GO:0045760)	2.49675088
82	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.49642989
83	melanocyte differentiation (GO:0030318)	2.48321861
84	response to UV-C (GO:0010225)	2.44162449
85	chromosome organization involved in meiosis (GO:0070192)	2.43969868
86	heme transport (GO:0015886)	2.43453892
87	rRNA catabolic process (GO:0016075)	2.43380253
88	synapsis (GO:0007129)	2.42991414
89	prostate gland growth (GO:0060736)	2.41882280
90	fatty acid transmembrane transport (GO:1902001)	2.41100603
91	behavioral response to nicotine (GO:0035095)	2.39593944
92	microtubule depolymerization (GO:0007019)	2.39564148
93	epithelial cilium movement (GO:0003351)	2.39126549
94	methionine metabolic process (GO:0006555)	2.38883436
95	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.38394368
96	oxidative demethylation (GO:0070989)	2.34959618
97	cellular response to exogenous dsRNA (GO:0071360)	2.33771842
98	microtubule polymerization or depolymerization (GO:0031109)	2.32863490
99	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.32035557
100	positive regulation of glycolytic process (GO:0045821)	2.31808543

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.27204544
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.25903366
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.96508969
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.73806372
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.73107943
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.72626597
7	ER_23166858_ChIP-Seq_MCF-7_Human	2.72071161
8	VDR_22108803_ChIP-Seq_LS180_Human	2.45497187
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.45240335
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39330076
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37045613
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.34899699
13	E2F7_22180533_ChIP-Seq_HELA_Human	2.24767940
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.22358944
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.21371320
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.17924566
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.13249057
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.11001321
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.99047237
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.96580666
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.94757661
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93415176
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.90314410
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.88692570
25	EWS_26573619_Chip-Seq_HEK293_Human	1.86800976
26	P300_19829295_ChIP-Seq_ESCs_Human	1.86390388
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81612991
28	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.79637746
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.75933687
30	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.73448473
31	STAT3_23295773_ChIP-Seq_U87_Human	1.70473217
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69089928
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.69089928
34	TCF4_23295773_ChIP-Seq_U87_Human	1.63328031
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.60886487
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52298869
37	FUS_26573619_Chip-Seq_HEK293_Human	1.50242694
38	TP53_16413492_ChIP-PET_HCT116_Human	1.50049800
39	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.49724048
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47341737
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39325560
42	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.38671951
43	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34899792
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34670447
45	AR_25329375_ChIP-Seq_VCAP_Human	1.29652149
46	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.29532188
47	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.29219046
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28082689
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26610742
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26474417
51	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.25974605
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23793011
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23793011
54	HOXB7_26014856_ChIP-Seq_BT474_Human	1.22623406
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.22574365
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22153945
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21756364
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.21756364
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21112690
60	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.17289637
61	AR_20517297_ChIP-Seq_VCAP_Human	1.17155463
62	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17003297
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16137802
64	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.14707164
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14678888
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14678888
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.13127121
68	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.12759866
69	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.12759866
70	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.12759866
71	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.11479578
72	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.10603491
73	SCL_19346495_ChIP-Seq_HPC-7_Human	1.10274696
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10094089
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09055861
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08915920
77	RXR_22108803_ChIP-Seq_LS180_Human	1.08377819
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08048690
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07992887
80	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07927599
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07418613
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.07183168
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.05635953
84	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05386613
85	TBL1_22424771_ChIP-Seq_293T_Human	1.05378275
86	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.04322868
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03874073
88	RUNX_20019798_ChIP-Seq_JUKART_Human	1.03673325
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02710152
90	ETV1_20927104_ChIP-Seq_GIST48_Human	1.01749440
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99642057
92	NFYB_21822215_ChIP-Seq_K562_Human	0.98421395
93	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.98388643
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97764531
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96777968
96	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.96643142
97	GATA3_26560356_Chip-Seq_TH1_Human	0.95682104
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95279510
99	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94528069
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93797787

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.80725766
2	MP0004147_increased_porphyrin_level	4.17363243
3	MP0009780_abnormal_chondrocyte_physiolo	3.89468306
4	MP0005646_abnormal_pituitary_gland	3.42542089
5	MP0008057_abnormal_DNA_replication	3.19230166
6	MP0003136_yellow_coat_color	3.15449747
7	MP0008877_abnormal_DNA_methylation	2.76659122
8	MP0003787_abnormal_imprinting	2.49565538
9	MP0003195_calcinosis	2.23271713
10	MP0000383_abnormal_hair_follicle	2.12658823
11	MP0005174_abnormal_tail_pigmentation	2.12498696
12	MP0009046_muscle_twitch	2.10033208
13	MP0000015_abnormal_ear_pigmentation	2.00937305
14	MP0004885_abnormal_endolymph	1.92407999
15	MP0005410_abnormal_fertilization	1.90567678
16	MP0002653_abnormal_ependyma_morphology	1.88594603
17	MP0008961_abnormal_basal_metabolism	1.88419768
18	MP0004043_abnormal_pH_regulation	1.83565125
19	MP0000427_abnormal_hair_cycle	1.82913876
20	MP0002638_abnormal_pupillary_reflex	1.79118639
21	MP0005551_abnormal_eye_electrophysiolog	1.77883692
22	MP0002095_abnormal_skin_pigmentation	1.77517868
23	MP0001501_abnormal_sleep_pattern	1.75653860
24	MP0008058_abnormal_DNA_repair	1.64316478
25	MP0001968_abnormal_touch/_nociception	1.62839004
26	MP0000372_irregular_coat_pigmentation	1.59847622
27	MP0000371_diluted_coat_color	1.50425689
28	MP0005670_abnormal_white_adipose	1.45749768
29	MP0002837_dystrophic_cardiac_calcinosis	1.42267942
30	MP0008872_abnormal_physiological_respon	1.39193352
31	MP0003183_abnormal_peptide_metabolism	1.38660912
32	MP0005171_absent_coat_pigmentation	1.38174794
33	MP0002138_abnormal_hepatobiliary_system	1.38006545
34	MP0001764_abnormal_homeostasis	1.35747109
35	MP0005075_abnormal_melanosome_morpholog	1.33636395
36	MP0005379_endocrine/exocrine_gland_phen	1.32352334
37	MP0004381_abnormal_hair_follicle	1.32020377
38	MP0010678_abnormal_skin_adnexa	1.31629361
39	MP0008995_early_reproductive_senescence	1.31594028
40	MP0000470_abnormal_stomach_morphology	1.30949081
41	MP0009745_abnormal_behavioral_response	1.26241743
42	MP0000631_abnormal_neuroendocrine_gland	1.21191330
43	MP0001929_abnormal_gametogenesis	1.20967736
44	MP0005253_abnormal_eye_physiology	1.20054142
45	MP0002736_abnormal_nociception_after	1.16803616
46	MP0003950_abnormal_plasma_membrane	1.14973566
47	MP0002160_abnormal_reproductive_system	1.14736439
48	MP0001873_stomach_inflammation	1.14196155
49	MP0010094_abnormal_chromosome_stability	1.13820366
50	MP0002876_abnormal_thyroid_physiology	1.11521022
51	MP0001502_abnormal_circadian_rhythm	1.09045794
52	MP0004134_abnormal_chest_morphology	1.08588332
53	MP0010329_abnormal_lipoprotein_level	1.08124422
54	MP0003698_abnormal_male_reproductive	1.08019551
55	MP0003718_maternal_effect	1.07769434
56	MP0005083_abnormal_biliary_tract	1.07537631
57	MP0004742_abnormal_vestibular_system	1.06207400
58	MP0010307_abnormal_tumor_latency	1.04616151
59	MP0002938_white_spotting	1.01788604
60	MP0002210_abnormal_sex_determination	0.95312811
61	MP0003172_abnormal_lysosome_physiology	0.95121371
62	MP0005389_reproductive_system_phenotype	0.92710726
63	MP0001664_abnormal_digestion	0.92175091
64	MP0001919_abnormal_reproductive_system	0.90288236
65	MP0003890_abnormal_embryonic-extraembry	0.87680420
66	MP0002009_preneoplasia	0.85772417
67	MP0002064_seizures	0.82378741
68	MP0001486_abnormal_startle_reflex	0.81925616
69	MP0003646_muscle_fatigue	0.81824230
70	MP0002272_abnormal_nervous_system	0.81708132
71	MP0009697_abnormal_copulation	0.81185881
72	MP0003936_abnormal_reproductive_system	0.81108071
73	MP0003786_premature_aging	0.80319829
74	MP0002067_abnormal_sensory_capabilities	0.80056011
75	MP0003806_abnormal_nucleotide_metabolis	0.78944249
76	MP0002075_abnormal_coat/hair_pigmentati	0.78747960
77	MP0004142_abnormal_muscle_tone	0.78172828
78	MP0001145_abnormal_male_reproductive	0.77325158
79	MP0004883_abnormal_blood_vessel	0.77066690
80	MP0002557_abnormal_social/conspecific_i	0.76921580
81	MP0001800_abnormal_humoral_immune	0.75761573
82	MP0003763_abnormal_thymus_physiology	0.74617386
83	MP0001984_abnormal_olfaction	0.74190464
84	MP0002928_abnormal_bile_duct	0.73810287
85	MP0000653_abnormal_sex_gland	0.73653474
86	MP0002396_abnormal_hematopoietic_system	0.73215796
87	MP0001485_abnormal_pinna_reflex	0.73114446
88	MP0005376_homeostasis/metabolism_phenot	0.72905875
89	MP0000647_abnormal_sebaceous_gland	0.72698709
90	MP0005266_abnormal_metabolism	0.70231594
91	MP0000613_abnormal_salivary_gland	0.70130205
92	MP0005085_abnormal_gallbladder_physiolo	0.67453225
93	MP0005636_abnormal_mineral_homeostasis	0.66807081
94	MP0002163_abnormal_gland_morphology	0.65316813
95	MP0001851_eye_inflammation	0.64938338
96	MP0005187_abnormal_penis_morphology	0.64099890
97	MP0002572_abnormal_emotion/affect_behav	0.63345389
98	MP0006292_abnormal_olfactory_placode	0.62013594
99	MP0001324_abnormal_eye_pigmentation	0.61036233
100	MP0009115_abnormal_fat_cell	0.58623789

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.57188196
2	Chromsome breakage (HP:0040012)	3.87815788
3	Pancreatic fibrosis (HP:0100732)	3.76179905
4	Molar tooth sign on MRI (HP:0002419)	3.69532103
5	Abnormality of midbrain morphology (HP:0002418)	3.69532103
6	Abnormality of the renal cortex (HP:0011035)	3.61178212
7	Type II lissencephaly (HP:0007260)	3.60614679
8	True hermaphroditism (HP:0010459)	3.51267677
9	Renal cortical cysts (HP:0000803)	3.48426439
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.33132139
11	Protruding tongue (HP:0010808)	3.13551307
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.00288753
13	Absent/shortened dynein arms (HP:0200106)	3.00288753
14	Cystic liver disease (HP:0006706)	2.94383538
15	Gaze-evoked nystagmus (HP:0000640)	2.84729872
16	Generalized hypopigmentation of hair (HP:0011358)	2.82553603
17	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.82265159
18	Nephronophthisis (HP:0000090)	2.75521146
19	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.71118691
20	Abnormality of the ileum (HP:0001549)	2.66482971
21	Abnormality of chromosome stability (HP:0003220)	2.65153212
22	Neoplasm of the oral cavity (HP:0100649)	2.63710244
23	Delayed CNS myelination (HP:0002188)	2.63346865
24	Meckel diverticulum (HP:0002245)	2.61989195
25	Abnormality of the renal medulla (HP:0100957)	2.61670302
26	Clubbing of toes (HP:0100760)	2.56698247
27	Febrile seizures (HP:0002373)	2.53529750
28	Retinal dysplasia (HP:0007973)	2.48377737
29	Focal motor seizures (HP:0011153)	2.47431776
30	Abnormality of the preputium (HP:0100587)	2.46396186
31	Supernumerary bones of the axial skeleton (HP:0009144)	2.44707866
32	Thyroid-stimulating hormone excess (HP:0002925)	2.39581421
33	Furrowed tongue (HP:0000221)	2.38614519
34	Median cleft lip (HP:0000161)	2.37221716
35	Sloping forehead (HP:0000340)	2.35575838
36	Male pseudohermaphroditism (HP:0000037)	2.31745816
37	Concave nail (HP:0001598)	2.30541408
38	Widely spaced teeth (HP:0000687)	2.29069009
39	Medial flaring of the eyebrow (HP:0010747)	2.28447670
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.24204452
41	Hypoplastic ischia (HP:0003175)	2.22406917
42	Supernumerary ribs (HP:0005815)	2.17005732
43	Fair hair (HP:0002286)	2.15165640
44	Patellar aplasia (HP:0006443)	2.13657019
45	Duodenal stenosis (HP:0100867)	2.13554621
46	Small intestinal stenosis (HP:0012848)	2.13554621
47	Abnormality of the carotid arteries (HP:0005344)	2.11991776
48	Aplasia/Hypoplasia of the patella (HP:0006498)	2.11204404
49	Volvulus (HP:0002580)	2.06378560
50	Hyperventilation (HP:0002883)	2.05551935
51	Inability to walk (HP:0002540)	2.05034940
52	Absence seizures (HP:0002121)	2.03887997
53	Congenital stationary night blindness (HP:0007642)	2.03388657
54	Oligodactyly (hands) (HP:0001180)	1.98179178
55	Atonic seizures (HP:0010819)	1.97086929
56	Chronic hepatic failure (HP:0100626)	1.92408062
57	Abnormality of DNA repair (HP:0003254)	1.92103410
58	Astigmatism (HP:0000483)	1.90876735
59	Clumsiness (HP:0002312)	1.90818574
60	Abnormality of the duodenum (HP:0002246)	1.90251683
61	Congenital sensorineural hearing impairment (HP:0008527)	1.87843774
62	Dialeptic seizures (HP:0011146)	1.86142401
63	Bilateral microphthalmos (HP:0007633)	1.84932737
64	Congenital hepatic fibrosis (HP:0002612)	1.83625652
65	Abnormality of lateral ventricle (HP:0030047)	1.83422665
66	Abnormal ciliary motility (HP:0012262)	1.83076019
67	Congenital, generalized hypertrichosis (HP:0004540)	1.82082034
68	Attenuation of retinal blood vessels (HP:0007843)	1.81620004
69	Postaxial foot polydactyly (HP:0001830)	1.81103917
70	Preaxial hand polydactyly (HP:0001177)	1.80842077
71	Abnormality of alanine metabolism (HP:0010916)	1.78906015
72	Hyperalaninemia (HP:0003348)	1.78906015
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78906015
74	Tubulointerstitial nephritis (HP:0001970)	1.78497388
75	Abnormal sex determination (HP:0012244)	1.76087030
76	Sex reversal (HP:0012245)	1.76087030
77	Oligohydramnios (HP:0001562)	1.76070613
78	Stomach cancer (HP:0012126)	1.74992169
79	Hypoplastic iliac wings (HP:0002866)	1.74658974
80	Albinism (HP:0001022)	1.74531130
81	Abnormality of the ischium (HP:0003174)	1.73029283
82	Decreased circulating renin level (HP:0003351)	1.71340771
83	Highly arched eyebrow (HP:0002553)	1.70901895
84	Large for gestational age (HP:0001520)	1.70686085
85	3-Methylglutaconic aciduria (HP:0003535)	1.70619943
86	Lissencephaly (HP:0001339)	1.70026744
87	Intellectual disability, progressive (HP:0006887)	1.67966624
88	Poikilocytosis (HP:0004447)	1.67755033
89	High pitched voice (HP:0001620)	1.67388633
90	Abnormality of the sella turcica (HP:0002679)	1.66554934
91	Deformed sella turcica (HP:0002681)	1.64584969
92	Aganglionic megacolon (HP:0002251)	1.63382475
93	Dyskinesia (HP:0100660)	1.62296194
94	J-shaped sella turcica (HP:0002680)	1.61488604
95	Ocular albinism (HP:0001107)	1.61387935
96	Focal seizures (HP:0007359)	1.61222802
97	Neoplasm of the adrenal cortex (HP:0100641)	1.61137886
98	Bile duct proliferation (HP:0001408)	1.59914749
99	Abnormal biliary tract physiology (HP:0012439)	1.59914749
100	Facial hemangioma (HP:0000329)	1.57682932

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.49553199
2	BMPR1B	4.19541714
3	PNCK	3.20436109
4	TLK1	3.00147595
5	PINK1	2.90098705
6	BRSK2	2.65969412
7	MARK3	2.60014009
8	ZAK	2.59388952
9	ACVR1B	2.56418863
10	TAOK3	2.27432695
11	ADRBK2	2.03910583
12	CDK3	1.97463068
13	WEE1	1.95381890
14	NUAK1	1.83590362
15	TNIK	1.61207406
16	GRK1	1.60398658
17	NTRK3	1.60394391
18	TEC	1.42788222
19	MAPKAPK3	1.40771885
20	TXK	1.33921665
21	MAPK13	1.32973004
22	WNK4	1.29553959
23	PTK2B	1.27116199
24	IKBKE	1.21108390
25	INSRR	1.20717905
26	TGFBR1	1.19693284
27	MAPKAPK5	1.19420613
28	PIK3CA	1.18868508
29	NTRK2	1.16218519
30	PLK4	1.13641912
31	PKN1	1.11983192
32	MAP4K2	1.10173105
33	LATS1	1.09005357
34	PAK3	1.07099280
35	MST4	1.06856945
36	MAPK15	1.04347295
37	CHUK	1.03158631
38	STK38L	1.00570996
39	PLK2	0.98882263
40	ADRBK1	0.95729703
41	BMPR2	0.92248024
42	TRPM7	0.91473806
43	TNK2	0.85093919
44	NEK2	0.84210803
45	STK3	0.83528275
46	MAP2K6	0.82590394
47	PIM1	0.81998042
48	PRKCE	0.81752127
49	PRKCQ	0.81623098
50	STK39	0.77916611
51	EIF2AK2	0.77074341
52	CSNK1D	0.72614659
53	STK16	0.68236860
54	PRKCG	0.65849706
55	MAP3K2	0.65118369
56	STK38	0.61873803
57	CAMKK2	0.61588433
58	DMPK	0.61436061
59	CAMK1G	0.61421723
60	RIPK1	0.60977089
61	VRK1	0.59710084
62	BTK	0.59098195
63	ATM	0.57459118
64	GRK6	0.57280504
65	RPS6KB1	0.55829765
66	GRK5	0.55405803
67	MAP2K1	0.54667298
68	IKBKB	0.54138426
69	RPS6KA5	0.54016054
70	JAK1	0.48543130
71	NLK	0.47972952
72	SYK	0.47871631
73	MELK	0.47325445
74	TSSK6	0.47190065
75	MAPKAPK2	0.45982007
76	PLK1	0.45877984
77	PRKCI	0.45789714
78	PLK3	0.43063717
79	CHEK2	0.39566015
80	PRKD3	0.39446759
81	PHKG2	0.38445519
82	PHKG1	0.38445519
83	CCNB1	0.38239846
84	ATR	0.38007306
85	BRSK1	0.37475866
86	SGK1	0.37178480
87	MET	0.36180851
88	RPS6KB2	0.35402222
89	MAPK11	0.34277557
90	WNK1	0.33210119
91	PRKG1	0.32389254
92	RPS6KA3	0.32118665
93	CDK7	0.31441686
94	STK10	0.30765735
95	NEK6	0.30477829
96	CSNK1E	0.29840602
97	CDK8	0.29404884
98	TGFBR2	0.29294341
99	CDC7	0.29213534
100	CAMK1	0.28630920

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.08822934
2	Homologous recombination_Homo sapiens_hsa03440	3.08821641
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.95167872
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.91638455
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.72326696
6	Phototransduction_Homo sapiens_hsa04744	2.62592345
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.48866449
8	Olfactory transduction_Homo sapiens_hsa04740	2.46856750
9	One carbon pool by folate_Homo sapiens_hsa00670	1.94322460
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.87180650
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.85398896
12	ABC transporters_Homo sapiens_hsa02010	1.81469099
13	Basal transcription factors_Homo sapiens_hsa03022	1.79036360
14	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.70477741
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69897503
16	Butanoate metabolism_Homo sapiens_hsa00650	1.58732488
17	Salivary secretion_Homo sapiens_hsa04970	1.57643815
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.57028569
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.51016666
20	Taste transduction_Homo sapiens_hsa04742	1.41374179
21	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.40365759
22	Mismatch repair_Homo sapiens_hsa03430	1.38749382
23	Caffeine metabolism_Homo sapiens_hsa00232	1.38199950
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32777798
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31716476
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.31591036
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.30415923
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.30004931
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.19965861
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17953981
31	Nicotine addiction_Homo sapiens_hsa05033	1.17586125
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.14944173
33	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.11906133
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05499840
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.01532901
36	Mineral absorption_Homo sapiens_hsa04978	1.01150434
37	Morphine addiction_Homo sapiens_hsa05032	0.97881607
38	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.96349063
39	Circadian entrainment_Homo sapiens_hsa04713	0.96061846
40	Sphingolipid metabolism_Homo sapiens_hsa00600	0.95419176
41	Oocyte meiosis_Homo sapiens_hsa04114	0.93518513
42	Primary immunodeficiency_Homo sapiens_hsa05340	0.91522760
43	Platelet activation_Homo sapiens_hsa04611	0.90657937
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.90358912
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90311899
46	Renin secretion_Homo sapiens_hsa04924	0.89199900
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89063639
48	Retinol metabolism_Homo sapiens_hsa00830	0.87295855
49	Insulin secretion_Homo sapiens_hsa04911	0.87291488
50	Circadian rhythm_Homo sapiens_hsa04710	0.84009705
51	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.83363816
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.83249896
53	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.82879189
54	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.82141924
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.82134698
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.81769197
57	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.80154023
58	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.80025528
59	RNA degradation_Homo sapiens_hsa03018	0.79186170
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.75971384
61	Gastric acid secretion_Homo sapiens_hsa04971	0.73058985
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72586822
63	Peroxisome_Homo sapiens_hsa04146	0.72258970
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.70607475
65	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.68220966
66	GABAergic synapse_Homo sapiens_hsa04727	0.64915484
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.64485429
68	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.63479988
69	Serotonergic synapse_Homo sapiens_hsa04726	0.63055736
70	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.62144843
71	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.60586948
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60081450
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.58606037
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52742694
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51646349
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51155472
77	PPAR signaling pathway_Homo sapiens_hsa03320	0.50353388
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.49993913
79	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.49065295
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48678021
81	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.48180401
82	Pancreatic secretion_Homo sapiens_hsa04972	0.47873867
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47510285
84	Estrogen signaling pathway_Homo sapiens_hsa04915	0.46355711
85	Lysine degradation_Homo sapiens_hsa00310	0.44262687
86	DNA replication_Homo sapiens_hsa03030	0.43931891
87	Choline metabolism in cancer_Homo sapiens_hsa05231	0.40886505
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.40865390
89	Propanoate metabolism_Homo sapiens_hsa00640	0.40443454
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.39705302
91	Base excision repair_Homo sapiens_hsa03410	0.39394803
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38708731
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38349206
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38198003
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36461447
96	Histidine metabolism_Homo sapiens_hsa00340	0.36066726
97	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.34913296
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33605412
99	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.32637448
100	Cell cycle_Homo sapiens_hsa04110	0.32208164

ANKRD20A11P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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