ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cilium movement (GO:0003352)	6.56342455
2	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	5.51761196
3	behavioral response to nicotine (GO:0035095)	5.08746855
4	meiotic chromosome segregation (GO:0045132)	4.98856391
5	resolution of meiotic recombination intermediates (GO:0000712)	4.89663120
6	synaptonemal complex assembly (GO:0007130)	4.86486033
7	synapsis (GO:0007129)	4.80126255
8	motile cilium assembly (GO:0044458)	4.65611825
9	chromosome organization involved in meiosis (GO:0070192)	4.53395933
10	synaptonemal complex organization (GO:0070193)	4.46946167
11	positive regulation of meiosis (GO:0045836)	4.37373531
12	histamine transport (GO:0051608)	4.26158333
13	auditory receptor cell stereocilium organization (GO:0060088)	4.24094953
14	drug transmembrane transport (GO:0006855)	4.21634731
15	organic cation transport (GO:0015695)	4.20422487
16	regulation of microtubule-based movement (GO:0060632)	4.10914345
17	positive regulation of meiotic cell cycle (GO:0051446)	4.09532386
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.05815621
19	quaternary ammonium group transport (GO:0015697)	4.05269958
20	detection of chemical stimulus involved in sensory perception (GO:0050907)	3.93319818
21	epithelial cilium movement (GO:0003351)	3.89298762
22	male meiosis I (GO:0007141)	3.75972398
23	righting reflex (GO:0060013)	3.72994018
24	cilium movement (GO:0003341)	3.69646102
25	cilium or flagellum-dependent cell motility (GO:0001539)	3.66325439
26	piRNA metabolic process (GO:0034587)	3.64399720
27	exogenous drug catabolic process (GO:0042738)	3.62064282
28	neurotransmitter biosynthetic process (GO:0042136)	3.55598341
29	centriole replication (GO:0007099)	3.55247384
30	reciprocal meiotic recombination (GO:0007131)	3.55057634
31	reciprocal DNA recombination (GO:0035825)	3.55057634
32	DNA methylation involved in gamete generation (GO:0043046)	3.53773111
33	positive regulation of protein homodimerization activity (GO:0090073)	3.46309072
34	neurotransmitter metabolic process (GO:0042133)	3.42577016
35	regulation of meiosis I (GO:0060631)	3.41548925
36	startle response (GO:0001964)	3.37098072
37	protein K6-linked ubiquitination (GO:0085020)	3.35410809
38	polyol catabolic process (GO:0046174)	3.31283584
39	attachment of spindle microtubules to kinetochore (GO:0008608)	3.31100185
40	male meiosis (GO:0007140)	3.29104994
41	regulation of sarcomere organization (GO:0060297)	3.25891319
42	rRNA catabolic process (GO:0016075)	3.18654263
43	rRNA methylation (GO:0031167)	3.16499076
44	adaptation of signaling pathway (GO:0023058)	3.14831360
45	acrosome reaction (GO:0007340)	3.09253189
46	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	3.09022067
47	short-term memory (GO:0007614)	3.08081103
48	sulfation (GO:0051923)	3.07370576
49	drug catabolic process (GO:0042737)	3.06568181
50	regulation of pigment cell differentiation (GO:0050932)	3.04688531
51	histone H3-K36 demethylation (GO:0070544)	3.04267084
52	water-soluble vitamin biosynthetic process (GO:0042364)	3.01237150
53	hindbrain development (GO:0030902)	3.00276802
54	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99620015
55	meiosis I (GO:0007127)	2.98779038
56	glycine transport (GO:0015816)	2.97211226
57	fucose catabolic process (GO:0019317)	2.93743101
58	L-fucose metabolic process (GO:0042354)	2.93743101
59	L-fucose catabolic process (GO:0042355)	2.93743101
60	regulation of skeletal muscle contraction (GO:0014819)	2.92399275
61	sensory perception of smell (GO:0007608)	2.88114888
62	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.86430748
63	establishment of protein localization to Golgi (GO:0072600)	2.84854852
64	fatty acid transmembrane transport (GO:1902001)	2.83610768
65	positive regulation of glycolytic process (GO:0045821)	2.82912071
66	positive regulation of developmental pigmentation (GO:0048087)	2.82622901
67	protein K48-linked deubiquitination (GO:0071108)	2.81494222
68	otic vesicle formation (GO:0030916)	2.80754406
69	retinal cone cell development (GO:0046549)	2.79858857
70	kynurenine metabolic process (GO:0070189)	2.79127809
71	detection of chemical stimulus (GO:0009593)	2.78816824
72	negative regulation of neurotransmitter transport (GO:0051589)	2.78163260
73	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.77708085
74	multicellular organism reproduction (GO:0032504)	2.77204810
75	axoneme assembly (GO:0035082)	2.75231644
76	gonadal mesoderm development (GO:0007506)	2.74887340
77	centriole assembly (GO:0098534)	2.72229461
78	oxidative demethylation (GO:0070989)	2.71852899
79	negative regulation of response to food (GO:0032096)	2.68621452
80	negative regulation of appetite (GO:0032099)	2.68621452
81	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.68152834
82	tooth mineralization (GO:0034505)	2.67914277
83	mitochondrial DNA replication (GO:0006264)	2.67281842
84	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.67124091
85	negative regulation of epidermal cell differentiation (GO:0045605)	2.66771070
86	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.64846698
87	indole-containing compound catabolic process (GO:0042436)	2.64741016
88	indolalkylamine catabolic process (GO:0046218)	2.64741016
89	tryptophan catabolic process (GO:0006569)	2.64741016
90	double-strand break repair via homologous recombination (GO:0000724)	2.63566600
91	tyrosine metabolic process (GO:0006570)	2.63218927
92	autophagic vacuole fusion (GO:0000046)	2.61725277
93	dopamine transport (GO:0015872)	2.60709268
94	negative regulation of systemic arterial blood pressure (GO:0003085)	2.59699200
95	drug transport (GO:0015893)	2.59463390
96	recombinational repair (GO:0000725)	2.58306197
97	C4-dicarboxylate transport (GO:0015740)	2.57045056
98	positive regulation of catecholamine secretion (GO:0033605)	2.56424793
99	meiotic cell cycle process (GO:1903046)	2.56221672
100	lymphangiogenesis (GO:0001946)	2.54328159

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.40640206
2	GBX2_23144817_ChIP-Seq_PC3_Human	4.15139613
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.57484889
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.53190592
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.45888714
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.23410525
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04017379
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.87494103
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.61771040
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.47057932
11	EWS_26573619_Chip-Seq_HEK293_Human	2.44152063
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.42248544
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.25162857
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.25051086
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16744531
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13968948
17	FUS_26573619_Chip-Seq_HEK293_Human	2.07729468
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.01266312
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97733740
20	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.87773253
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84541019
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77221071
23	P300_19829295_ChIP-Seq_ESCs_Human	1.72255036
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.71695173
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.71695173
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.71287093
27	TCF4_23295773_ChIP-Seq_U87_Human	1.71152939
28	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.69477587
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69146724
30	STAT3_23295773_ChIP-Seq_U87_Human	1.67965079
31	AR_21572438_ChIP-Seq_LNCaP_Human	1.67131164
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.63389786
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.63367051
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.60816252
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49998922
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49833109
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.48287866
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48087252
39	AR_25329375_ChIP-Seq_VCAP_Human	1.47836404
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46094945
41	RUNX2_22187159_ChIP-Seq_PCA_Human	1.45298794
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.44692348
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.41629697
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41293450
45	GATA1_22025678_ChIP-Seq_K562_Human	1.40321791
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39817986
47	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.38847441
48	RXR_22108803_ChIP-Seq_LS180_Human	1.37812867
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35866030
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35866030
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35388492
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35388492
53	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.32040702
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32029397
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.30234816
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28714046
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27675710
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26739400
59	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.25759341
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25250972
61	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.23588298
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22359023
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22065889
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22063440
65	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.21665558
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21093539
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20682580
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18828098
69	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17964395
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.16569970
71	ETV1_20927104_ChIP-Seq_GIST48_Human	1.16305828
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16178252
73	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15732371
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13921547
75	NFYB_21822215_ChIP-Seq_K562_Human	1.12825217
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11894279
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10215793
78	TP53_16413492_ChIP-PET_HCT116_Human	1.08174397
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06116398
80	AR_20517297_ChIP-Seq_VCAP_Human	1.05743340
81	TBL1_22424771_ChIP-Seq_293T_Human	1.04463071
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03931040
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.02175077
84	CDX2_22108803_ChIP-Seq_LS180_Human	1.01918998
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00611959
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00550689
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00404535
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99888492
89	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.99842660
90	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.98376419
91	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98196740
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98147028
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98147028
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96735832
95	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.95532544
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.95480312
97	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.95419890
98	GATA3_26560356_Chip-Seq_TH1_Human	0.94835974
99	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.94438798
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93422668

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.82754719
2	MP0002837_dystrophic_cardiac_calcinosis	4.08034173
3	MP0003646_muscle_fatigue	3.73563496
4	MP0003950_abnormal_plasma_membrane	3.28656244
5	MP0003136_yellow_coat_color	3.28224301
6	MP0004084_abnormal_cardiac_muscle	3.16629165
7	MP0009697_abnormal_copulation	3.16536477
8	MP0000372_irregular_coat_pigmentation	2.95805755
9	MP0004147_increased_porphyrin_level	2.61958182
10	MP0004381_abnormal_hair_follicle	2.51710376
11	MP0000569_abnormal_digit_pigmentation	2.37498247
12	MP0004043_abnormal_pH_regulation	2.36900968
13	MP0002160_abnormal_reproductive_system	2.35813512
14	MP0004145_abnormal_muscle_electrophysio	2.30598473
15	MP0005410_abnormal_fertilization	2.05828978
16	MP0004215_abnormal_myocardial_fiber	1.98841638
17	MP0005085_abnormal_gallbladder_physiolo	1.96238532
18	MP0005647_abnormal_sex_gland	1.95825895
19	MP0010386_abnormal_urinary_bladder	1.87419893
20	MP0000427_abnormal_hair_cycle	1.82930108
21	MP0008872_abnormal_physiological_respon	1.79436700
22	MP0008775_abnormal_heart_ventricle	1.76462145
23	MP0005167_abnormal_blood-brain_barrier	1.74524887
24	MP0003718_maternal_effect	1.74053629
25	MP0005646_abnormal_pituitary_gland	1.72527431
26	MP0001664_abnormal_digestion	1.69102687
27	MP0006036_abnormal_mitochondrial_physio	1.66525794
28	MP0005551_abnormal_eye_electrophysiolog	1.64969084
29	MP0004036_abnormal_muscle_relaxation	1.64681327
30	MP0005187_abnormal_penis_morphology	1.64589827
31	MP0001968_abnormal_touch/_nociception	1.61286141
32	MP0004484_altered_response_of	1.56427671
33	MP0008058_abnormal_DNA_repair	1.53320602
34	MP0005171_absent_coat_pigmentation	1.47425784
35	MP0002254_reproductive_system_inflammat	1.41512872
36	MP0005389_reproductive_system_phenotype	1.37832756
37	MP0003698_abnormal_male_reproductive	1.34651849
38	MP0001929_abnormal_gametogenesis	1.34516613
39	MP0005075_abnormal_melanosome_morpholog	1.34240227
40	MP0006138_congestive_heart_failure	1.27351139
41	MP0004885_abnormal_endolymph	1.25455989
42	MP0002272_abnormal_nervous_system	1.24076446
43	MP0006276_abnormal_autonomic_nervous	1.23879993
44	MP0002876_abnormal_thyroid_physiology	1.22980908
45	MP0002210_abnormal_sex_determination	1.17828848
46	MP0008877_abnormal_DNA_methylation	1.15016349
47	MP0002736_abnormal_nociception_after	1.14700979
48	MP0006292_abnormal_olfactory_placode	1.14457050
49	MP0001764_abnormal_homeostasis	1.12066127
50	MP0009046_muscle_twitch	1.11383293
51	MP0002234_abnormal_pharynx_morphology	1.10218934
52	MP0009745_abnormal_behavioral_response	1.10167857
53	MP0001501_abnormal_sleep_pattern	1.05580135
54	MP0002138_abnormal_hepatobiliary_system	1.04273204
55	MP0001919_abnormal_reproductive_system	1.04000258
56	MP0001879_abnormal_lymphatic_vessel	1.03609950
57	MP0001986_abnormal_taste_sensitivity	0.98651707
58	MP0005266_abnormal_metabolism	0.96994503
59	MP0003693_abnormal_embryo_hatching	0.95874763
60	MP0002269_muscular_atrophy	0.93888874
61	MP0003195_calcinosis	0.93527141
62	MP0002095_abnormal_skin_pigmentation	0.93423343
63	MP0000647_abnormal_sebaceous_gland	0.93201488
64	MP0005620_abnormal_muscle_contractility	0.92262836
65	MP0004134_abnormal_chest_morphology	0.91731393
66	MP0001984_abnormal_olfaction	0.91119791
67	MP0004085_abnormal_heartbeat	0.90178459
68	MP0000230_abnormal_systemic_arterial	0.89506425
69	MP0005334_abnormal_fat_pad	0.88961267
70	MP0005330_cardiomyopathy	0.88848126
71	MP0000653_abnormal_sex_gland	0.87694630
72	MP0000749_muscle_degeneration	0.86576694
73	MP0005385_cardiovascular_system_phenoty	0.83252263
74	MP0001544_abnormal_cardiovascular_syste	0.83252263
75	MP0004130_abnormal_muscle_cell	0.79753595
76	MP0001145_abnormal_male_reproductive	0.79357593
77	MP0006035_abnormal_mitochondrial_morpho	0.78874629
78	MP0005174_abnormal_tail_pigmentation	0.77895545
79	MP0001873_stomach_inflammation	0.77523585
80	MP0010368_abnormal_lymphatic_system	0.77015707
81	MP0000538_abnormal_urinary_bladder	0.75784694
82	MP0002638_abnormal_pupillary_reflex	0.74251477
83	MP0002163_abnormal_gland_morphology	0.73656610
84	MP0009115_abnormal_fat_cell	0.72252906
85	MP0001486_abnormal_startle_reflex	0.71707269
86	MP0001963_abnormal_hearing_physiology	0.71007377
87	MP0005332_abnormal_amino_acid	0.69378883
88	MP0005376_homeostasis/metabolism_phenot	0.66555440
89	MP0004742_abnormal_vestibular_system	0.66304013
90	MP0002822_catalepsy	0.64768803
91	MP0000631_abnormal_neuroendocrine_gland	0.64081504
92	MP0005253_abnormal_eye_physiology	0.63522800
93	MP0004883_abnormal_blood_vessel	0.63060825
94	MP0002161_abnormal_fertility/fecundity	0.62668076
95	MP0001440_abnormal_grooming_behavior	0.62596533
96	MP0002693_abnormal_pancreas_physiology	0.62107203
97	MP0001661_extended_life_span	0.62098492
98	MP0002108_abnormal_muscle_morphology	0.61989042
99	MP0000470_abnormal_stomach_morphology	0.60898212
100	MP0002972_abnormal_cardiac_muscle	0.60741217

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the fovea (HP:0007750)	5.04614410
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.04614410
3	Renal cortical cysts (HP:0000803)	4.44164842
4	Abnormality of the renal cortex (HP:0011035)	4.07953353
5	Abnormality of midbrain morphology (HP:0002418)	3.95955989
6	Molar tooth sign on MRI (HP:0002419)	3.95955989
7	Abnormality of the fovea (HP:0000493)	3.74759315
8	Pancreatic cysts (HP:0001737)	3.72043868
9	Volvulus (HP:0002580)	3.53824497
10	Pancreatic fibrosis (HP:0100732)	3.53155842
11	Aplasia/Hypoplasia of the macula (HP:0008059)	3.46543837
12	True hermaphroditism (HP:0010459)	3.34098799
13	Unilateral renal agenesis (HP:0000122)	3.30324076
14	Medial flaring of the eyebrow (HP:0010747)	3.25862756
15	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.21901783
16	Methylmalonic acidemia (HP:0002912)	3.09148999
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.08699629
18	Absent/shortened dynein arms (HP:0200106)	3.08699629
19	Concave nail (HP:0001598)	3.08677558
20	Type II lissencephaly (HP:0007260)	3.04748327
21	Nephrogenic diabetes insipidus (HP:0009806)	3.01685853
22	Inability to walk (HP:0002540)	3.01208457
23	Bilateral microphthalmos (HP:0007633)	2.98306265
24	Conjugated hyperbilirubinemia (HP:0002908)	2.95417080
25	Progressive inability to walk (HP:0002505)	2.92522805
26	Hyperventilation (HP:0002883)	2.82685790
27	Abnormal ciliary motility (HP:0012262)	2.75722472
28	Aplasia cutis congenita (HP:0001057)	2.73630984
29	Polydipsia (HP:0001959)	2.70267181
30	Abnormal drinking behavior (HP:0030082)	2.70267181
31	3-Methylglutaconic aciduria (HP:0003535)	2.63164353
32	Clumsiness (HP:0002312)	2.59135126
33	Gaze-evoked nystagmus (HP:0000640)	2.55257882
34	Nephronophthisis (HP:0000090)	2.54993999
35	Cystic liver disease (HP:0006706)	2.53451313
36	Congenital primary aphakia (HP:0007707)	2.49615167
37	Congenital stationary night blindness (HP:0007642)	2.49323587
38	Median cleft lip (HP:0000161)	2.46253643
39	Hypoplastic ischia (HP:0003175)	2.46138061
40	Decreased central vision (HP:0007663)	2.45889865
41	Gait imbalance (HP:0002141)	2.42803469
42	Cerebellar dysplasia (HP:0007033)	2.39250338
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.36432448
44	Bulbous nose (HP:0000414)	2.34764845
45	Congenital sensorineural hearing impairment (HP:0008527)	2.33405821
46	Large for gestational age (HP:0001520)	2.29737593
47	Increased circulating renin level (HP:0000848)	2.28700557
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26758763
49	Abnormality of the ischium (HP:0003174)	2.24060632
50	Poor coordination (HP:0002370)	2.23862851
51	Furrowed tongue (HP:0000221)	2.21177857
52	Amelogenesis imperfecta (HP:0000705)	2.20896697
53	Severe muscular hypotonia (HP:0006829)	2.17118445
54	Abnormality of the renal medulla (HP:0100957)	2.13475293
55	Protruding tongue (HP:0010808)	2.12119678
56	J-shaped sella turcica (HP:0002680)	2.11826020
57	Methylmalonic aciduria (HP:0012120)	2.08848695
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.07153437
59	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.06772063
60	Syncope (HP:0001279)	2.05740996
61	Partial agenesis of the corpus callosum (HP:0001338)	2.05273867
62	Abnormality of alanine metabolism (HP:0010916)	2.04924773
63	Hyperalaninemia (HP:0003348)	2.04924773
64	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04924773
65	Bony spicule pigmentary retinopathy (HP:0007737)	2.04763762
66	Abnormal respiratory motile cilium physiology (HP:0012261)	2.02420824
67	Decreased circulating renin level (HP:0003351)	1.99967596
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.98950952
69	Abnormal respiratory motile cilium morphology (HP:0005938)	1.98950952
70	Tubular atrophy (HP:0000092)	1.96851061
71	Congenital hepatic fibrosis (HP:0002612)	1.96711404
72	Generalized hypopigmentation of hair (HP:0011358)	1.96143765
73	Sclerocornea (HP:0000647)	1.93971482
74	Fair hair (HP:0002286)	1.92815412
75	Calf muscle hypertrophy (HP:0008981)	1.91004943
76	Abnormality of renin-angiotensin system (HP:0000847)	1.89194501
77	Abnormality of vitamin B metabolism (HP:0004340)	1.88443165
78	Short chin (HP:0000331)	1.85062988
79	Male pseudohermaphroditism (HP:0000037)	1.84975251
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84608485
81	Polyuria (HP:0000103)	1.84512794
82	Proximal tubulopathy (HP:0000114)	1.84439828
83	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.84077152
84	Attenuation of retinal blood vessels (HP:0007843)	1.83651594
85	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.83364148
86	Acute encephalopathy (HP:0006846)	1.82342454
87	Widely spaced teeth (HP:0000687)	1.82199642
88	Hypomagnesemia (HP:0002917)	1.78513177
89	Acute necrotizing encephalopathy (HP:0006965)	1.77067396
90	Absent speech (HP:0001344)	1.76755552
91	Azoospermia (HP:0000027)	1.76137035
92	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.75980824
93	Lissencephaly (HP:0001339)	1.74263473
94	Mixed hearing impairment (HP:0000410)	1.72295822
95	Ventricular fibrillation (HP:0001663)	1.71669167
96	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.70706617
97	Tetany (HP:0001281)	1.70624877
98	Muscle hypertrophy of the lower extremities (HP:0008968)	1.68639390
99	Oligohydramnios (HP:0001562)	1.68359361
100	Progressive macrocephaly (HP:0004481)	1.68306841

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	7.07803397
2	FRK	4.32971017
3	PINK1	4.26641700
4	NEK2	4.10157718
5	RIPK4	3.65621134
6	WNK4	3.05161851
7	TLK1	2.95893576
8	BMPR2	2.52506244
9	STK39	2.26095594
10	ACVR1B	2.13613354
11	TIE1	2.00071019
12	PLK4	1.97016896
13	OBSCN	1.96035910
14	MARK3	1.86332256
15	TNIK	1.84523651
16	STK38L	1.79603935
17	MAPK15	1.77423201
18	OXSR1	1.64132079
19	CCNB1	1.63964455
20	BMPR1B	1.61683925
21	ADRBK2	1.49266190
22	TAOK3	1.41236359
23	MAPKAPK5	1.40876636
24	PTK2B	1.37549220
25	MAPK13	1.35558620
26	AKT3	1.33841834
27	GRK1	1.23722304
28	TRPM7	1.15628294
29	MAP3K2	1.08060447
30	ZAK	1.07421113
31	MAP3K7	0.97037598
32	STK3	0.93328830
33	SIK2	0.91190319
34	RPS6KB2	0.80365137
35	MAPKAPK3	0.76402477
36	MAP4K2	0.73487137
37	TEC	0.71315504
38	MYLK	0.70906959
39	PIK3CA	0.69979294
40	ADRBK1	0.69279711
41	NME1	0.68354790
42	NTRK3	0.67585026
43	MAP2K1	0.67048734
44	CDK3	0.63773010
45	MUSK	0.63444489
46	STK38	0.63039817
47	PRKAA2	0.60125830
48	CASK	0.59927419
49	TSSK6	0.59426042
50	PHKG1	0.58560916
51	PHKG2	0.58560916
52	RPS6KA5	0.58210324
53	PKN1	0.51668616
54	TNK2	0.49992993
55	DAPK2	0.49272613
56	LATS1	0.48894613
57	CAMK4	0.48216331
58	NLK	0.44782897
59	CHEK2	0.44652756
60	WEE1	0.44416679
61	PRKAA1	0.42316673
62	PRKCG	0.42286512
63	PRKACB	0.42198797
64	INSRR	0.39294145
65	NUAK1	0.38597196
66	PRKG2	0.38217361
67	ERBB2	0.35101558
68	EIF2AK3	0.33824732
69	MELK	0.33100007
70	PLK2	0.32257669
71	SIK3	0.32073079
72	MAPK12	0.31713954
73	CAMK1	0.31434436
74	SGK2	0.30906415
75	VRK1	0.30595293
76	AURKA	0.30287818
77	MAPK4	0.28807642
78	RPS6KA6	0.27897581
79	EEF2K	0.27870120
80	ILK	0.27867053
81	RPS6KB1	0.27247258
82	CSNK1A1	0.26837883
83	ICK	0.26134579
84	BTK	0.25900361
85	CSNK1G1	0.25851568
86	PRKACG	0.25461106
87	AKT2	0.24453962
88	CAMK2A	0.24274254
89	PRKACA	0.23743055
90	PRKG1	0.23742902
91	CSNK1G2	0.23203301
92	PAK1	0.22244123
93	TGFBR1	0.22026459
94	IGF1R	0.21581798
95	BUB1	0.21426220
96	AURKB	0.21166361
97	WNK3	0.21157088
98	WNK1	0.21025735
99	PDK2	0.20901786
100	NEK6	0.20026994

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	4.69167919
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.62180185
3	Basal transcription factors_Homo sapiens_hsa03022	2.54401714
4	Homologous recombination_Homo sapiens_hsa03440	2.52739521
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.44047206
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.37376806
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.15872086
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.12319288
9	Butanoate metabolism_Homo sapiens_hsa00650	2.05249614
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99123294
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87816910
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.77800605
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.73928606
14	Regulation of autophagy_Homo sapiens_hsa04140	1.67804325
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.65983397
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.64239404
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.63348694
18	Phototransduction_Homo sapiens_hsa04744	1.62408220
19	ABC transporters_Homo sapiens_hsa02010	1.55748459
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.52104942
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50760226
22	One carbon pool by folate_Homo sapiens_hsa00670	1.46367022
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.46253402
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.44134923
25	RNA degradation_Homo sapiens_hsa03018	1.43679385
26	Salivary secretion_Homo sapiens_hsa04970	1.43422253
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42047705
28	Taste transduction_Homo sapiens_hsa04742	1.41747904
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31467834
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.28708563
31	Propanoate metabolism_Homo sapiens_hsa00640	1.25864909
32	Retinol metabolism_Homo sapiens_hsa00830	1.25321313
33	Nicotine addiction_Homo sapiens_hsa05033	1.23675789
34	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.23284853
35	Circadian entrainment_Homo sapiens_hsa04713	1.22210967
36	Insulin secretion_Homo sapiens_hsa04911	1.19365154
37	Calcium signaling pathway_Homo sapiens_hsa04020	1.13087895
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.09413948
39	Morphine addiction_Homo sapiens_hsa05032	1.07315999
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.06475900
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04941300
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03440621
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01783458
44	Gastric acid secretion_Homo sapiens_hsa04971	1.00610334
45	Tyrosine metabolism_Homo sapiens_hsa00350	0.97381842
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.96502801
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.95198717
48	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.92776134
49	Mineral absorption_Homo sapiens_hsa04978	0.90637086
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.87283039
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.85569452
52	Circadian rhythm_Homo sapiens_hsa04710	0.85363269
53	Caffeine metabolism_Homo sapiens_hsa00232	0.83239839
54	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.82650121
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.80543770
56	Arginine biosynthesis_Homo sapiens_hsa00220	0.80453297
57	Histidine metabolism_Homo sapiens_hsa00340	0.79417241
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79327702
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.79194550
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76320803
61	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.75632500
62	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.73138569
63	Oxidative phosphorylation_Homo sapiens_hsa00190	0.72633717
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.72199635
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71920301
66	GABAergic synapse_Homo sapiens_hsa04727	0.71823468
67	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70652790
68	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.70284819
69	Bile secretion_Homo sapiens_hsa04976	0.68440962
70	Pancreatic secretion_Homo sapiens_hsa04972	0.67960267
71	Purine metabolism_Homo sapiens_hsa00230	0.66937497
72	Serotonergic synapse_Homo sapiens_hsa04726	0.64844636
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64787002
74	Renin secretion_Homo sapiens_hsa04924	0.62860227
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62613244
76	Long-term depression_Homo sapiens_hsa04730	0.61087093
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.60010773
78	Insulin resistance_Homo sapiens_hsa04931	0.57787173
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57270186
80	Choline metabolism in cancer_Homo sapiens_hsa05231	0.57192832
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.51583160
82	Peroxisome_Homo sapiens_hsa04146	0.49931844
83	Cholinergic synapse_Homo sapiens_hsa04725	0.49881556
84	Mismatch repair_Homo sapiens_hsa03430	0.48876351
85	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48844175
86	African trypanosomiasis_Homo sapiens_hsa05143	0.48609437
87	Parkinsons disease_Homo sapiens_hsa05012	0.43973109
88	PPAR signaling pathway_Homo sapiens_hsa03320	0.43037785
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41337304
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.41182572
91	Melanoma_Homo sapiens_hsa05218	0.39673131
92	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.39478148
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.38236983
94	Amphetamine addiction_Homo sapiens_hsa05031	0.37047850
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.35618228
96	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.34790578
97	Huntingtons disease_Homo sapiens_hsa05016	0.34610872
98	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34182440
99	Type II diabetes mellitus_Homo sapiens_hsa04930	0.33585204
100	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.33376891

ANKRD20A17P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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