ANKRD20A18P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)5.25599450
2pyrimidine nucleotide catabolic process (GO:0006244)5.13481458
3DNA double-strand break processing (GO:0000729)5.02229453
4DNA strand elongation involved in DNA replication (GO:0006271)4.92171352
5DNA replication checkpoint (GO:0000076)4.84239324
6telomere maintenance via recombination (GO:0000722)4.72111986
7nucleotide-excision repair, DNA gap filling (GO:0006297)4.70390105
8DNA strand elongation (GO:0022616)4.60749530
9chromatin remodeling at centromere (GO:0031055)4.39890483
10mitotic recombination (GO:0006312)4.38652746
11CENP-A containing nucleosome assembly (GO:0034080)4.32694258
12dopamine transport (GO:0015872)4.20051151
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.91583669
14histone exchange (GO:0043486)3.90795962
15viral mRNA export from host cell nucleus (GO:0046784)3.88842935
16DNA ligation (GO:0006266)3.87654335
17pyrimidine ribonucleoside catabolic process (GO:0046133)3.83836050
18sequestering of actin monomers (GO:0042989)3.81508355
19establishment of viral latency (GO:0019043)3.79759374
20establishment of integrated proviral latency (GO:0075713)3.79191842
21replication fork processing (GO:0031297)3.76588476
22cysteine metabolic process (GO:0006534)3.74037516
23DNA catabolic process, exonucleolytic (GO:0000738)3.71157411
24response to misfolded protein (GO:0051788)3.70323144
25somite rostral/caudal axis specification (GO:0032525)3.68832560
26nucleoside diphosphate catabolic process (GO:0009134)3.67841960
27positive thymic T cell selection (GO:0045059)3.66597009
28DNA strand renaturation (GO:0000733)3.66013585
29translesion synthesis (GO:0019985)3.65439439
30telomere maintenance via telomere lengthening (GO:0010833)3.65356250
31mismatch repair (GO:0006298)3.64806861
32synapsis (GO:0007129)3.63470119
33regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62542605
34regulation of mitotic spindle checkpoint (GO:1903504)3.62542605
35postreplication repair (GO:0006301)3.60178486
36regulation of double-strand break repair via homologous recombination (GO:0010569)3.58151700
37protein-cofactor linkage (GO:0018065)3.55669764
38regulation of mesoderm development (GO:2000380)3.54298751
39negative regulation of DNA-dependent DNA replication (GO:2000104)3.50363364
40DNA synthesis involved in DNA repair (GO:0000731)3.50128622
41synaptonemal complex assembly (GO:0007130)3.43319232
42pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.41086217
43meiosis I (GO:0007127)3.39352265
44chromosome organization involved in meiosis (GO:0070192)3.38361225
45reciprocal meiotic recombination (GO:0007131)3.34561071
46reciprocal DNA recombination (GO:0035825)3.34561071
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30090433
48cytochrome complex assembly (GO:0017004)3.27455639
49regulation of hydrogen peroxide metabolic process (GO:0010310)3.24066122
50positive T cell selection (GO:0043368)3.19231393
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16968646
52pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.16733521
53UMP biosynthetic process (GO:0006222)3.16733521
54pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.16733521
55UMP metabolic process (GO:0046049)3.16733521
56synaptonemal complex organization (GO:0070193)3.15860497
57DNA biosynthetic process (GO:0071897)3.15496245
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13529851
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13464640
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13464640
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13464640
62pyrimidine ribonucleotide metabolic process (GO:0009218)3.12196624
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12154155
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12154155
65recombinational repair (GO:0000725)3.11997558
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10022419
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08982466
68DNA replication-independent nucleosome assembly (GO:0006336)3.08474193
69DNA replication-independent nucleosome organization (GO:0034724)3.08474193
70endothelial tube morphogenesis (GO:0061154)3.07141036
71morphogenesis of an endothelium (GO:0003159)3.07141036
72proteasome assembly (GO:0043248)3.04594590
73telomere maintenance (GO:0000723)3.04049875
74catecholamine transport (GO:0051937)3.03272041
75signal transduction involved in cell cycle checkpoint (GO:0072395)3.02845307
76DNA recombination (GO:0006310)3.02718158
77pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.02560120
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00558734
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.00558734
80protein complex biogenesis (GO:0070271)3.00328498
81deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.98885154
82DNA damage response, detection of DNA damage (GO:0042769)2.98084007
83base-excision repair (GO:0006284)2.96921356
84telomere organization (GO:0032200)2.96300113
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95558144
86regulation of meiosis I (GO:0060631)2.89586381
87double-strand break repair via homologous recombination (GO:0000724)2.87344726
88piRNA metabolic process (GO:0034587)2.86500131
89respiratory chain complex IV assembly (GO:0008535)2.86049590
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.85009645
91somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85009645
92mitochondrial respiratory chain complex assembly (GO:0033108)2.84479277
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82715487
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.82197063
95negative regulation of ligase activity (GO:0051352)2.81867680
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81867680
97resolution of meiotic recombination intermediates (GO:0000712)2.80951967
98positive regulation of meiotic cell cycle (GO:0051446)2.79884492
99negative T cell selection (GO:0043383)2.79486122
100serine family amino acid biosynthetic process (GO:0009070)2.78451170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.37278015
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96500477
3IGF1R_20145208_ChIP-Seq_DFB_Human3.68172805
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.39669163
5IRF1_19129219_ChIP-ChIP_H3396_Human3.37710278
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35556908
7VDR_22108803_ChIP-Seq_LS180_Human2.79390695
8ZNF274_21170338_ChIP-Seq_K562_Hela2.69406605
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.68122241
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.62183948
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51061345
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.41127079
13ELK1_19687146_ChIP-ChIP_HELA_Human2.35484749
14EWS_26573619_Chip-Seq_HEK293_Human2.32271565
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19374653
16TAF15_26573619_Chip-Seq_HEK293_Human2.11961591
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04438354
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00682831
19GBX2_23144817_ChIP-Seq_PC3_Human1.97869045
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95227893
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91262651
22VDR_23849224_ChIP-Seq_CD4+_Human1.87644325
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85649261
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72063288
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72057819
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70942850
27TP53_22573176_ChIP-Seq_HFKS_Human1.69558028
28HTT_18923047_ChIP-ChIP_STHdh_Human1.67448383
29FUS_26573619_Chip-Seq_HEK293_Human1.67007471
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63473973
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58385258
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57739964
33P300_19829295_ChIP-Seq_ESCs_Human1.57517791
34FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.56948808
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54414041
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.53756753
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.53675132
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53375511
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50489569
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45981448
41FOXP3_21729870_ChIP-Seq_TREG_Human1.45350413
42ER_23166858_ChIP-Seq_MCF-7_Human1.42694134
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39840724
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38134979
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.37963182
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35475448
47CBP_20019798_ChIP-Seq_JUKART_Human1.31028186
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31028186
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.30331321
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29813844
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26098726
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25907567
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25325421
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.24038324
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23691561
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.22435259
57MYC_18940864_ChIP-ChIP_HL60_Human1.21021617
58CIITA_25753668_ChIP-Seq_RAJI_Human1.19754296
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18923050
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.17861309
61HOXB7_26014856_ChIP-Seq_BT474_Human1.17560348
62NCOR_22424771_ChIP-Seq_293T_Human1.15977534
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.15501821
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14526877
65RUNX2_22187159_ChIP-Seq_PCA_Human1.13376170
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12870427
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.10759739
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10296716
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08771050
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.08771050
71BCAT_22108803_ChIP-Seq_LS180_Human1.07432419
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.06912772
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06459525
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.05936984
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05772512
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04396700
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03876712
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03815358
79RNF2_27304074_Chip-Seq_NSC_Mouse1.02500544
80E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02090673
81TCF4_22108803_ChIP-Seq_LS180_Human1.02086994
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.00842787
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99166758
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98183927
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96851286
86CBX2_27304074_Chip-Seq_ESCs_Mouse0.96654914
87SALL1_21062744_ChIP-ChIP_HESCs_Human0.96645722
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96215050
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95717348
90AR_25329375_ChIP-Seq_VCAP_Human0.94249260
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.93788154
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93681976
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92257151
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92000277
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91496870
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90927024
97STAT3_23295773_ChIP-Seq_U87_Human0.90885349
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89866306
99SMAD4_21799915_ChIP-Seq_A2780_Human0.88400052
100AR_21572438_ChIP-Seq_LNCaP_Human0.88211835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.46328169
2MP0003123_paternal_imprinting3.59622923
3MP0003787_abnormal_imprinting3.52798832
4MP0010094_abnormal_chromosome_stability3.49317357
5MP0003890_abnormal_embryonic-extraembry3.24480594
6MP0002102_abnormal_ear_morphology2.96078076
7MP0003283_abnormal_digestive_organ2.83727461
8MP0000372_irregular_coat_pigmentation2.46916519
9MP0002163_abnormal_gland_morphology2.35082713
10MP0001529_abnormal_vocalization2.31433877
11MP0003878_abnormal_ear_physiology2.19172339
12MP0005377_hearing/vestibular/ear_phenot2.19172339
13MP0010386_abnormal_urinary_bladder2.17398849
14MP0000427_abnormal_hair_cycle2.10640172
15MP0001968_abnormal_touch/_nociception2.09340892
16MP0008057_abnormal_DNA_replication2.02420258
17MP0003111_abnormal_nucleus_morphology2.01293756
18MP0008877_abnormal_DNA_methylation1.93868676
19MP0001764_abnormal_homeostasis1.91549774
20MP0004133_heterotaxia1.83736473
21MP0002736_abnormal_nociception_after1.82794988
22MP0005171_absent_coat_pigmentation1.74842198
23MP0003183_abnormal_peptide_metabolism1.74385939
24MP0006292_abnormal_olfactory_placode1.68810634
25MP0004957_abnormal_blastocyst_morpholog1.64247474
26MP0009697_abnormal_copulation1.63918831
27MP0008872_abnormal_physiological_respon1.62375797
28MP0003121_genomic_imprinting1.59703160
29MP0005379_endocrine/exocrine_gland_phen1.58026863
30MP0002210_abnormal_sex_determination1.48749181
31MP0001929_abnormal_gametogenesis1.47919108
32MP0003119_abnormal_digestive_system1.46532037
33MP0000569_abnormal_digit_pigmentation1.46274256
34MP0006072_abnormal_retinal_apoptosis1.44706443
35MP0005551_abnormal_eye_electrophysiolog1.42821366
36MP0000490_abnormal_crypts_of1.42005393
37MP0002837_dystrophic_cardiac_calcinosis1.41417796
38MP0003786_premature_aging1.32861603
39MP0001119_abnormal_female_reproductive1.32826882
40MP0001145_abnormal_male_reproductive1.31661218
41MP0005645_abnormal_hypothalamus_physiol1.30360929
42MP0000653_abnormal_sex_gland1.27792036
43MP0001485_abnormal_pinna_reflex1.27192787
44MP0005075_abnormal_melanosome_morpholog1.25768348
45MP0004147_increased_porphyrin_level1.24794765
46MP0003136_yellow_coat_color1.22784650
47MP0003567_abnormal_fetal_cardiomyocyte1.18636836
48MP0002160_abnormal_reproductive_system1.18437469
49MP0006054_spinal_hemorrhage1.18332556
50MP0004742_abnormal_vestibular_system1.15745895
51MP0008932_abnormal_embryonic_tissue1.15251451
52MP0005389_reproductive_system_phenotype1.15234396
53MP0000613_abnormal_salivary_gland1.13122400
54MP0000631_abnormal_neuroendocrine_gland1.11919255
55MP0001293_anophthalmia1.11325977
56MP0001963_abnormal_hearing_physiology1.11131932
57MP0003195_calcinosis1.10637113
58MP0000647_abnormal_sebaceous_gland1.10369080
59MP0000026_abnormal_inner_ear1.08504164
60MP0005671_abnormal_response_to1.07420085
61MP0003950_abnormal_plasma_membrane1.07247844
62MP0008995_early_reproductive_senescence1.05510533
63MP0005310_abnormal_salivary_gland1.05506922
64MP0000538_abnormal_urinary_bladder1.04857311
65MP0008004_abnormal_stomach_pH1.03920455
66MP0002277_abnormal_respiratory_mucosa1.02868361
67MP0002751_abnormal_autonomic_nervous1.02506680
68MP0002938_white_spotting1.02077059
69MP0005253_abnormal_eye_physiology1.01965649
70MP0002933_joint_inflammation0.97715708
71MP0003941_abnormal_skin_development0.96922209
72MP0003137_abnormal_impulse_conducting0.95769315
73MP0003698_abnormal_male_reproductive0.95641657
74MP0004215_abnormal_myocardial_fiber0.92948672
75MP0010368_abnormal_lymphatic_system0.92702767
76MP0002735_abnormal_chemical_nociception0.90636789
77MP0005220_abnormal_exocrine_pancreas0.90458266
78MP0005408_hypopigmentation0.88523335
79MP0001919_abnormal_reproductive_system0.86362654
80MP0000383_abnormal_hair_follicle0.85611738
81MP0002009_preneoplasia0.85447703
82MP0003077_abnormal_cell_cycle0.84427334
83MP0008007_abnormal_cellular_replicative0.81233456
84MP0004019_abnormal_vitamin_homeostasis0.78894682
85MP0000462_abnormal_digestive_system0.78756548
86MP0003699_abnormal_female_reproductive0.77838977
87MP0000049_abnormal_middle_ear0.77035135
88MP0005332_abnormal_amino_acid0.76721131
89MP0004145_abnormal_muscle_electrophysio0.76613080
90MP0003936_abnormal_reproductive_system0.76276938
91MP0000516_abnormal_urinary_system0.71312186
92MP0005367_renal/urinary_system_phenotyp0.71312186
93MP0003937_abnormal_limbs/digits/tail_de0.68126361
94MP0003880_abnormal_central_pattern0.65329211
95MP0003866_abnormal_defecation0.62786553
96MP0005187_abnormal_penis_morphology0.60279240
97MP0001286_abnormal_eye_development0.60020429
98MP0004924_abnormal_behavior0.59597530
99MP0005386_behavior/neurological_phenoty0.59597530
100MP0001486_abnormal_startle_reflex0.58417027

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)6.16651539
2Intestinal atresia (HP:0011100)5.30348107
3Retinal dysplasia (HP:0007973)4.33286970
4Oligodactyly (hands) (HP:0001180)4.28167909
5Carpal bone hypoplasia (HP:0001498)3.89162866
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.75033941
7Severe combined immunodeficiency (HP:0004430)3.69709086
8Abnormality of the parathyroid morphology (HP:0011766)3.65852947
9Cerebellar dysplasia (HP:0007033)3.58379175
10Congenital stationary night blindness (HP:0007642)3.57790440
11Gonadotropin excess (HP:0000837)3.46133141
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.30560973
13Combined immunodeficiency (HP:0005387)3.25262058
143-Methylglutaconic aciduria (HP:0003535)3.12466449
15Anterior segment dysgenesis (HP:0007700)3.09827838
16Colon cancer (HP:0003003)3.08310295
17Abnormal rod and cone electroretinograms (HP:0008323)2.94886280
18Oligodactyly (HP:0012165)2.92815533
19Hypothermia (HP:0002045)2.92024294
20Esophageal atresia (HP:0002032)2.91215165
21Gastrointestinal atresia (HP:0002589)2.88805701
22Acute necrotizing encephalopathy (HP:0006965)2.74181260
23Aqueductal stenosis (HP:0002410)2.71735218
24Amelogenesis imperfecta (HP:0000705)2.65604090
25Aplasia involving forearm bones (HP:0009822)2.64301954
26Absent forearm bone (HP:0003953)2.64301954
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.58085445
28Panhypogammaglobulinemia (HP:0003139)2.56940154
29Absent radius (HP:0003974)2.53877422
30Lissencephaly (HP:0001339)2.51567868
31Pancreatic cysts (HP:0001737)2.49984857
32Abnormality of the duodenum (HP:0002246)2.49758087
33Dandy-Walker malformation (HP:0001305)2.43357219
34Mitochondrial inheritance (HP:0001427)2.42467160
35Thyroiditis (HP:0100646)2.41695429
36Biliary tract neoplasm (HP:0100574)2.40558641
37Volvulus (HP:0002580)2.37876978
38Small intestinal stenosis (HP:0012848)2.37553855
39Duodenal stenosis (HP:0100867)2.37553855
40Abnormality of the ileum (HP:0001549)2.36608197
41Increased CSF lactate (HP:0002490)2.36287299
42Abnormal mitochondria in muscle tissue (HP:0008316)2.34461074
43Hypoplasia of the fovea (HP:0007750)2.32393417
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.32393417
45Chin dimple (HP:0010751)2.29427910
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29269226
47Pancreatic islet-cell hyperplasia (HP:0004510)2.27059891
48Anencephaly (HP:0002323)2.24030845
49Hepatocellular necrosis (HP:0001404)2.20311053
50Abnormality of chromosome stability (HP:0003220)2.19723641
51Progressive macrocephaly (HP:0004481)2.18579172
52Meckel diverticulum (HP:0002245)2.18510888
53Optic nerve hypoplasia (HP:0000609)2.17799994
54Occipital encephalocele (HP:0002085)2.16819565
55Aplasia/Hypoplasia of the ulna (HP:0006495)2.14835120
56Abnormal lung lobation (HP:0002101)2.13975854
57Hepatic necrosis (HP:0002605)2.13541648
58Bilateral microphthalmos (HP:0007633)2.13174212
59Irregular epiphyses (HP:0010582)2.12069702
60Triphalangeal thumb (HP:0001199)2.10746503
61Abnormal biliary tract physiology (HP:0012439)2.09714326
62Bile duct proliferation (HP:0001408)2.09714326
63Acute encephalopathy (HP:0006846)2.08974009
64Supernumerary spleens (HP:0009799)2.07506652
65True hermaphroditism (HP:0010459)2.07398736
66Abnormality of the fovea (HP:0000493)2.06019679
67Patellar aplasia (HP:0006443)2.05491623
68Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03473406
69Broad ribs (HP:0000885)2.02997044
70Intellectual disability, profound (HP:0002187)2.02035127
71Impaired vibration sensation in the lower limbs (HP:0002166)2.02001151
72Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00819341
73Abnormality of the labia minora (HP:0012880)1.99787844
74Ankle clonus (HP:0011448)1.99704258
75Double outlet right ventricle (HP:0001719)1.98864444
76Congenital malformation of the right heart (HP:0011723)1.98864444
77Non-midline cleft lip (HP:0100335)1.97983138
78Hypoproteinemia (HP:0003075)1.97000393
79Bony spicule pigmentary retinopathy (HP:0007737)1.96789378
80Mixed hearing impairment (HP:0000410)1.96415392
81Megaloblastic anemia (HP:0001889)1.93032820
82Hypoplasia of the ulna (HP:0003022)1.91325921
83Chorioretinal coloboma (HP:0000567)1.90988259
84Neoplasm of the colon (HP:0100273)1.90891126
85Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90797325
86Aplasia/Hypoplasia of the patella (HP:0006498)1.90316812
87Nuclear cataract (HP:0100018)1.89662128
88Ectopic kidney (HP:0000086)1.89221403
89Cerebral edema (HP:0002181)1.87445368
90Hypoplastic pelvis (HP:0008839)1.87119388
91Preaxial hand polydactyly (HP:0001177)1.86234010
92Abnormality of chromosome segregation (HP:0002916)1.83702583
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82498787
94Absent epiphyses (HP:0010577)1.82498787
95Fair hair (HP:0002286)1.82216184
96Impaired proprioception (HP:0010831)1.81211460
97Anophthalmia (HP:0000528)1.80916313
98Neoplasm of the small intestine (HP:0100833)1.80509773
99Tinnitus (HP:0000360)1.80005547
100Rhabdomyosarcoma (HP:0002859)1.79975663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.83554199
2PLK43.46081281
3FRK3.28711768
4VRK13.11152377
5ERBB42.78645975
6WEE12.54041330
7KDR2.22627530
8NUAK12.05470297
9CDC71.86172710
10BUB11.86075938
11BRSK21.82944126
12ADRBK21.74511341
13BMPR1B1.73207059
14TAF11.71720666
15WNK31.65091439
16GRK11.63242945
17ACVR1B1.60562637
18PLK31.59059589
19ERBB31.58541722
20DMPK1.57398876
21MST41.57119227
22BRSK11.53722470
23MELK1.53599679
24MAP3K41.51594555
25MYLK1.50845535
26ZAK1.49707666
27NLK1.47718765
28CAMKK21.44105677
29GRK51.35736476
30CSNK1G11.34853684
31WNK41.32661860
32BCR1.31334856
33MKNK11.31111760
34CSNK1G31.29962744
35CSNK1A1L1.27228738
36PLK21.19457534
37SRPK11.18973844
38TNIK1.18573114
39CSNK1G21.15172020
40EIF2AK31.14811260
41MAP2K71.14797309
42TSSK61.14196431
43ADRBK11.10562215
44MAPK131.08612881
45EIF2AK10.93001101
46TIE10.92874447
47TLK10.92670168
48IRAK20.92034127
49YES10.90458346
50PLK10.90068341
51BMX0.88761624
52TXK0.86883629
53ATR0.86385201
54MKNK20.83609100
55PASK0.83546251
56INSRR0.83188538
57TTK0.83142300
58CHEK20.83091728
59TGFBR10.76080026
60UHMK10.75335138
61CDK30.68190194
62AURKB0.67462658
63EIF2AK20.67449687
64MAP3K60.66222092
65CDK70.60983230
66CSNK1A10.60150374
67IRAK10.56370861
68MARK30.56285013
69STK160.55886820
70WNK10.55434823
71GRK60.54318781
72MAPK150.51709498
73TGFBR20.50453356
74ATM0.47751156
75PTK2B0.46478435
76GRK70.45865258
77TESK20.44835658
78OBSCN0.43954638
79TRIM280.42636988
80STK38L0.41518300
81CDK180.40124277
82CAMKK10.39614135
83FGR0.38628691
84CDK150.38584280
85FGFR20.38047663
86CSNK1D0.37545681
87CSNK2A10.36416258
88LIMK10.36367387
89CDK140.36358970
90SIK20.36099483
91PRKCQ0.35465804
92TAOK30.35053956
93GSK3A0.33469246
94DDR20.33228373
95STK110.32811484
96DYRK1B0.28255705
97PRKCG0.27572661
98CDK11A0.26444603
99NEK60.25954067
100PRKACA0.23838172

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.42222937
2DNA replication_Homo sapiens_hsa030304.38597584
3Homologous recombination_Homo sapiens_hsa034404.36667793
4Proteasome_Homo sapiens_hsa030504.10089858
5Non-homologous end-joining_Homo sapiens_hsa034503.32980163
6Fanconi anemia pathway_Homo sapiens_hsa034603.11470456
7Base excision repair_Homo sapiens_hsa034102.69158080
8Phototransduction_Homo sapiens_hsa047442.49614454
9Nucleotide excision repair_Homo sapiens_hsa034202.41963006
10One carbon pool by folate_Homo sapiens_hsa006702.33140855
11Primary immunodeficiency_Homo sapiens_hsa053402.31687062
12Pyrimidine metabolism_Homo sapiens_hsa002402.04434744
13Basal transcription factors_Homo sapiens_hsa030222.03886381
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93347037
15Asthma_Homo sapiens_hsa053101.52082267
16Oxidative phosphorylation_Homo sapiens_hsa001901.51726968
17RNA degradation_Homo sapiens_hsa030181.42990699
18Protein export_Homo sapiens_hsa030601.42218935
19Graft-versus-host disease_Homo sapiens_hsa053321.36453851
20Parkinsons disease_Homo sapiens_hsa050121.36405683
21Autoimmune thyroid disease_Homo sapiens_hsa053201.32812093
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31435848
23Purine metabolism_Homo sapiens_hsa002301.28007473
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27434194
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25061992
26Allograft rejection_Homo sapiens_hsa053301.23619572
27Propanoate metabolism_Homo sapiens_hsa006401.23095884
28Cell cycle_Homo sapiens_hsa041101.18338000
29RNA transport_Homo sapiens_hsa030131.17868894
30Spliceosome_Homo sapiens_hsa030401.13837470
31Selenocompound metabolism_Homo sapiens_hsa004501.11394701
32Butanoate metabolism_Homo sapiens_hsa006501.09565327
33RNA polymerase_Homo sapiens_hsa030201.09348643
34Antigen processing and presentation_Homo sapiens_hsa046121.08379779
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.03162918
36Huntingtons disease_Homo sapiens_hsa050161.00667090
37p53 signaling pathway_Homo sapiens_hsa041150.95314646
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94807623
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94602582
40Collecting duct acid secretion_Homo sapiens_hsa049660.94493967
41beta-Alanine metabolism_Homo sapiens_hsa004100.92196948
42Type I diabetes mellitus_Homo sapiens_hsa049400.86889155
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.83815370
44Alzheimers disease_Homo sapiens_hsa050100.82474708
45Phenylalanine metabolism_Homo sapiens_hsa003600.81373312
46Tyrosine metabolism_Homo sapiens_hsa003500.79213910
47Sulfur metabolism_Homo sapiens_hsa009200.76672316
48Oocyte meiosis_Homo sapiens_hsa041140.74398355
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72938335
50Taste transduction_Homo sapiens_hsa047420.71602544
51Herpes simplex infection_Homo sapiens_hsa051680.70681803
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.69885495
53Glutathione metabolism_Homo sapiens_hsa004800.68020613
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67660587
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66131837
56Systemic lupus erythematosus_Homo sapiens_hsa053220.65991359
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.65841454
58mRNA surveillance pathway_Homo sapiens_hsa030150.62756597
59Ribosome_Homo sapiens_hsa030100.60579144
60Viral myocarditis_Homo sapiens_hsa054160.60519995
61ABC transporters_Homo sapiens_hsa020100.57656330
62Tryptophan metabolism_Homo sapiens_hsa003800.55468819
63Calcium signaling pathway_Homo sapiens_hsa040200.53576857
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53340445
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50977346
66Wnt signaling pathway_Homo sapiens_hsa043100.50200009
67Rheumatoid arthritis_Homo sapiens_hsa053230.49408332
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48752443
69Cardiac muscle contraction_Homo sapiens_hsa042600.45024573
70Staphylococcus aureus infection_Homo sapiens_hsa051500.44820436
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42545652
72Renin secretion_Homo sapiens_hsa049240.40437187
73Regulation of autophagy_Homo sapiens_hsa041400.39154785
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38440441
75Arachidonic acid metabolism_Homo sapiens_hsa005900.37217387
76Fatty acid degradation_Homo sapiens_hsa000710.34852257
77HTLV-I infection_Homo sapiens_hsa051660.34845411
78Olfactory transduction_Homo sapiens_hsa047400.34666670
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34575241
80Metabolic pathways_Homo sapiens_hsa011000.33477583
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33044524
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32870666
83Nitrogen metabolism_Homo sapiens_hsa009100.32713184
84Fatty acid elongation_Homo sapiens_hsa000620.32472473
85Epstein-Barr virus infection_Homo sapiens_hsa051690.30178829
86Histidine metabolism_Homo sapiens_hsa003400.28234828
87Caffeine metabolism_Homo sapiens_hsa002320.26858556
88Hematopoietic cell lineage_Homo sapiens_hsa046400.24737360
89Sphingolipid metabolism_Homo sapiens_hsa006000.23281365
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.23257535
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22654934
92TGF-beta signaling pathway_Homo sapiens_hsa043500.22425559
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21102881
94Chemical carcinogenesis_Homo sapiens_hsa052040.20235325
95Linoleic acid metabolism_Homo sapiens_hsa005910.19070269
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18873173
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18449833
98Phagosome_Homo sapiens_hsa041450.17494940
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15584585
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15154155

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