ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	5.18246564
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.45257223
3	indolalkylamine metabolic process (GO:0006586)	4.32923499
4	indole-containing compound catabolic process (GO:0042436)	4.14881224
5	indolalkylamine catabolic process (GO:0046218)	4.14881224
6	tryptophan catabolic process (GO:0006569)	4.14881224
7	piRNA metabolic process (GO:0034587)	3.78137233
8	neural tube formation (GO:0001841)	3.74425757
9	reflex (GO:0060004)	3.73428810
10	photoreceptor cell maintenance (GO:0045494)	3.72417506
11	tryptophan metabolic process (GO:0006568)	3.68360870
12	kynurenine metabolic process (GO:0070189)	3.66804299
13	DNA methylation involved in gamete generation (GO:0043046)	3.66516610
14	righting reflex (GO:0060013)	3.62907834
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.60616527
16	detection of light stimulus involved in visual perception (GO:0050908)	3.60616527
17	signal peptide processing (GO:0006465)	3.57361926
18	cilium or flagellum-dependent cell motility (GO:0001539)	3.52905147
19	cellular ketone body metabolic process (GO:0046950)	3.50106794
20	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.46097152
21	monoubiquitinated protein deubiquitination (GO:0035520)	3.45648928
22	L-fucose catabolic process (GO:0042355)	3.38730447
23	fucose catabolic process (GO:0019317)	3.38730447
24	L-fucose metabolic process (GO:0042354)	3.38730447
25	regulation of sarcomere organization (GO:0060297)	3.28531338
26	regulation of skeletal muscle contraction (GO:0014819)	3.22484537
27	auditory receptor cell stereocilium organization (GO:0060088)	3.19451478
28	protein K11-linked deubiquitination (GO:0035871)	3.19339590
29	response to pheromone (GO:0019236)	3.18606575
30	axoneme assembly (GO:0035082)	3.18068500
31	ketone body metabolic process (GO:1902224)	3.16308067
32	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.15043300
33	regulation of action potential (GO:0098900)	3.11367754
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.11167493
35	DNA double-strand break processing (GO:0000729)	3.06600565
36	adenosine metabolic process (GO:0046085)	3.06051981
37	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.05304544
38	neuronal action potential propagation (GO:0019227)	2.98852922
39	indole-containing compound metabolic process (GO:0042430)	2.98713212
40	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.95484908
41	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.95484908
42	positive regulation of action potential (GO:0045760)	2.91297575
43	inner ear receptor stereocilium organization (GO:0060122)	2.91127858
44	regulation of hippo signaling (GO:0035330)	2.90620407
45	benzene-containing compound metabolic process (GO:0042537)	2.90265577
46	behavioral response to ethanol (GO:0048149)	2.88358235
47	proline transport (GO:0015824)	2.84846733
48	negative regulation of mast cell activation (GO:0033004)	2.84440451
49	regulation of meiosis I (GO:0060631)	2.82869068
50	gamma-aminobutyric acid transport (GO:0015812)	2.81316850
51	behavioral response to nicotine (GO:0035095)	2.78543891
52	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.78055983
53	regulation of cilium movement (GO:0003352)	2.77095614
54	resolution of meiotic recombination intermediates (GO:0000712)	2.74965175
55	positive regulation of developmental pigmentation (GO:0048087)	2.74708871
56	regulation of male gonad development (GO:2000018)	2.72266214
57	positive regulation of meiosis (GO:0045836)	2.70710351
58	response to nitrosative stress (GO:0051409)	2.69901853
59	amine catabolic process (GO:0009310)	2.69461634
60	cellular biogenic amine catabolic process (GO:0042402)	2.69461634
61	double-strand break repair via homologous recombination (GO:0000724)	2.68331750
62	recombinational repair (GO:0000725)	2.67612073
63	cellular response to sterol (GO:0036315)	2.67386807
64	response to inactivity (GO:0014854)	2.67048081
65	amino acid salvage (GO:0043102)	2.66781944
66	L-methionine salvage (GO:0071267)	2.66781944
67	L-methionine biosynthetic process (GO:0071265)	2.66781944
68	establishment of protein localization to Golgi (GO:0072600)	2.66746717
69	regulation of collateral sprouting (GO:0048670)	2.66385156
70	membrane depolarization during action potential (GO:0086010)	2.65855547
71	regulation of glucokinase activity (GO:0033131)	2.65832526
72	regulation of hexokinase activity (GO:1903299)	2.65832526
73	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.64127571
74	neuronal action potential (GO:0019228)	2.64011167
75	replication fork processing (GO:0031297)	2.63695057
76	positive regulation of meiotic cell cycle (GO:0051446)	2.63476063
77	positive regulation of vascular permeability (GO:0043117)	2.63123766
78	protein prenylation (GO:0018342)	2.62785795
79	prenylation (GO:0097354)	2.62785795
80	synapsis (GO:0007129)	2.62744396
81	xenobiotic catabolic process (GO:0042178)	2.62647342
82	adaptation of signaling pathway (GO:0023058)	2.61388891
83	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.59152083
84	cornea development in camera-type eye (GO:0061303)	2.58576355
85	DNA integration (GO:0015074)	2.58276482
86	thyroid hormone metabolic process (GO:0042403)	2.58048936
87	regulation of pigment cell differentiation (GO:0050932)	2.55099140
88	retinal cone cell development (GO:0046549)	2.54472284
89	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.54229192
90	methionine biosynthetic process (GO:0009086)	2.53650892
91	meiotic chromosome segregation (GO:0045132)	2.51754972
92	C4-dicarboxylate transport (GO:0015740)	2.51188859
93	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.49418842
94	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.49418842
95	regulation of translation, ncRNA-mediated (GO:0045974)	2.49418842
96	central nervous system neuron axonogenesis (GO:0021955)	2.48654687
97	nonmotile primary cilium assembly (GO:0035058)	2.48277267
98	positive regulation of digestive system process (GO:0060456)	2.45971537
99	regulation of uterine smooth muscle contraction (GO:0070472)	2.45142774
100	mannosylation (GO:0097502)	2.43657325

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.67784957
2	VDR_22108803_ChIP-Seq_LS180_Human	3.27567339
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.21375924
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.09200131
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.05173131
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.94847927
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.83126480
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.66506818
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.40341422
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34508249
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34189682
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29798908
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.23915698
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.22342159
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19908440
16	P300_19829295_ChIP-Seq_ESCs_Human	2.18182434
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12291505
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.07417137
19	ER_23166858_ChIP-Seq_MCF-7_Human	2.03278275
20	FUS_26573619_Chip-Seq_HEK293_Human	2.03006397
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.02705524
22	EWS_26573619_Chip-Seq_HEK293_Human	1.96243871
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.88033199
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83609537
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.82956004
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.82956004
27	STAT3_23295773_ChIP-Seq_U87_Human	1.82948271
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.82495553
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81816149
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.73397581
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.71350503
32	TCF4_23295773_ChIP-Seq_U87_Human	1.67318633
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.59417504
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57419247
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.57336351
36	AR_25329375_ChIP-Seq_VCAP_Human	1.57254594
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.53201002
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52533393
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.52092645
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46576712
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44926044
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.44495604
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.42291068
44	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42112713
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39477002
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38830273
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38642334
48	AR_21572438_ChIP-Seq_LNCaP_Human	1.38193728
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.37349854
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36905948
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36776070
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36776070
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36496300
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36165356
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36165356
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.36086673
57	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33728169
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33400150
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.32111811
60	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.28648059
61	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28611785
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28558612
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27388162
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.27108409
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26809362
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26642147
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21724178
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20077843
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.18570813
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17651712
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17353661
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.16698793
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14744423
74	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13564394
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11441955
76	TP53_16413492_ChIP-PET_HCT116_Human	1.11272746
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11200079
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08880757
79	KDM2B_26808549_Chip-Seq_REH_Human	1.08079704
80	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07877930
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06490358
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05800688
83	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05545540
84	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05095894
85	RXR_22108803_ChIP-Seq_LS180_Human	1.04904535
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02344687
87	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02115137
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01740159
89	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01281937
90	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01072510
91	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00624437
92	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.00272452
93	NCOR_22424771_ChIP-Seq_293T_Human	1.00030474
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99966634
95	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99830575
96	P300_18555785_Chip-Seq_ESCs_Mouse	0.99446219
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99177109
98	TBL1_22424771_ChIP-Seq_293T_Human	0.98294548
99	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.98038174
100	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97508264

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.53312820
2	MP0002736_abnormal_nociception_after	3.11470385
3	MP0001968_abnormal_touch/_nociception	2.89758500
4	MP0000569_abnormal_digit_pigmentation	2.78469068
5	MP0004147_increased_porphyrin_level	2.46315267
6	MP0002837_dystrophic_cardiac_calcinosis	2.44318792
7	MP0003195_calcinosis	2.42682502
8	MP0008057_abnormal_DNA_replication	2.37844835
9	MP0002102_abnormal_ear_morphology	2.36536563
10	MP0008877_abnormal_DNA_methylation	2.35821665
11	MP0005551_abnormal_eye_electrophysiolog	2.32363716
12	MP0004145_abnormal_muscle_electrophysio	2.18826180
13	MP0001529_abnormal_vocalization	2.11826308
14	MP0005646_abnormal_pituitary_gland	2.07412129
15	MP0008872_abnormal_physiological_respon	2.03376485
16	MP0001501_abnormal_sleep_pattern	1.99319757
17	MP0000427_abnormal_hair_cycle	1.97029307
18	MP0003880_abnormal_central_pattern	1.92234461
19	MP0004043_abnormal_pH_regulation	1.86000126
20	MP0009046_muscle_twitch	1.78073834
21	MP0002735_abnormal_chemical_nociception	1.74533651
22	MP0000372_irregular_coat_pigmentation	1.67301282
23	MP0002876_abnormal_thyroid_physiology	1.66530882
24	MP0006292_abnormal_olfactory_placode	1.65631261
25	MP0009745_abnormal_behavioral_response	1.63149122
26	MP0003136_yellow_coat_color	1.61567170
27	MP0009697_abnormal_copulation	1.61097974
28	MP0001984_abnormal_olfaction	1.60546425
29	MP0005253_abnormal_eye_physiology	1.58164562
30	MP0002938_white_spotting	1.58043737
31	MP0000383_abnormal_hair_follicle	1.55874801
32	MP0006276_abnormal_autonomic_nervous	1.54249267
33	MP0001486_abnormal_startle_reflex	1.53493322
34	MP0000631_abnormal_neuroendocrine_gland	1.51841961
35	MP0005645_abnormal_hypothalamus_physiol	1.49571838
36	MP0008995_early_reproductive_senescence	1.49544519
37	MP0009780_abnormal_chondrocyte_physiolo	1.38319647
38	MP0002272_abnormal_nervous_system	1.37597802
39	MP0001485_abnormal_pinna_reflex	1.37029980
40	MP0006072_abnormal_retinal_apoptosis	1.35737853
41	MP0005670_abnormal_white_adipose	1.34343643
42	MP0004924_abnormal_behavior	1.32119325
43	MP0005386_behavior/neurological_phenoty	1.32119325
44	MP0004215_abnormal_myocardial_fiber	1.29414096
45	MP0000749_muscle_degeneration	1.29409633
46	MP0001986_abnormal_taste_sensitivity	1.25851985
47	MP0008058_abnormal_DNA_repair	1.24849032
48	MP0003045_fibrosis	1.19717377
49	MP0005410_abnormal_fertilization	1.19469738
50	MP0002067_abnormal_sensory_capabilities	1.18386328
51	MP0005085_abnormal_gallbladder_physiolo	1.18230622
52	MP0003183_abnormal_peptide_metabolism	1.13838896
53	MP0002138_abnormal_hepatobiliary_system	1.10937811
54	MP0002168_other_aberrant_phenotype	1.09147213
55	MP0001970_abnormal_pain_threshold	1.07768018
56	MP0003698_abnormal_male_reproductive	1.05297950
57	MP0005377_hearing/vestibular/ear_phenot	1.05023875
58	MP0003878_abnormal_ear_physiology	1.05023875
59	MP0002234_abnormal_pharynx_morphology	1.05016654
60	MP0003950_abnormal_plasma_membrane	1.01339331
61	MP0005174_abnormal_tail_pigmentation	1.01265489
62	MP0005266_abnormal_metabolism	1.00641680
63	MP0003635_abnormal_synaptic_transmissio	1.00298887
64	MP0002733_abnormal_thermal_nociception	1.00200331
65	MP0002909_abnormal_adrenal_gland	1.00121252
66	MP0003252_abnormal_bile_duct	1.00011975
67	MP0001764_abnormal_homeostasis	0.98198179
68	MP0005171_absent_coat_pigmentation	0.97957498
69	MP0003718_maternal_effect	0.97533540
70	MP0008789_abnormal_olfactory_epithelium	0.96542988
71	MP0002638_abnormal_pupillary_reflex	0.96281565
72	MP0004133_heterotaxia	0.95839361
73	MP0002064_seizures	0.95270157
74	MP0004142_abnormal_muscle_tone	0.94649655
75	MP0001929_abnormal_gametogenesis	0.93393658
76	MP0002572_abnormal_emotion/affect_behav	0.93271245
77	MP0004085_abnormal_heartbeat	0.92614782
78	MP0002734_abnormal_mechanical_nocicepti	0.92003088
79	MP0008875_abnormal_xenobiotic_pharmacok	0.89971906
80	MP0005167_abnormal_blood-brain_barrier	0.89633252
81	MP0003787_abnormal_imprinting	0.89310051
82	MP0004742_abnormal_vestibular_system	0.88477247
83	MP0005395_other_phenotype	0.88246858
84	MP0002557_abnormal_social/conspecific_i	0.87511987
85	MP0004036_abnormal_muscle_relaxation	0.86962619
86	MP0010678_abnormal_skin_adnexa	0.86666470
87	MP0004130_abnormal_muscle_cell	0.85669225
88	MP0002822_catalepsy	0.84544222
89	MP0002095_abnormal_skin_pigmentation	0.83581705
90	MP0002229_neurodegeneration	0.83275292
91	MP0003137_abnormal_impulse_conducting	0.80862244
92	MP0004084_abnormal_cardiac_muscle	0.78572707
93	MP0002653_abnormal_ependyma_morphology	0.77490464
94	MP0000230_abnormal_systemic_arterial	0.76718587
95	MP0000653_abnormal_sex_gland	0.75827071
96	MP0010386_abnormal_urinary_bladder	0.74564714
97	MP0003890_abnormal_embryonic-extraembry	0.73854980
98	MP0002210_abnormal_sex_determination	0.72796194
99	MP0008775_abnormal_heart_ventricle	0.72749415
100	MP0003567_abnormal_fetal_cardiomyocyte	0.72483722

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.32861028
2	Pancreatic cysts (HP:0001737)	4.18378636
3	Gaze-evoked nystagmus (HP:0000640)	3.78697450
4	Pancreatic fibrosis (HP:0100732)	3.76259821
5	True hermaphroditism (HP:0010459)	3.61003782
6	Focal motor seizures (HP:0011153)	3.32351011
7	Attenuation of retinal blood vessels (HP:0007843)	3.26036436
8	Congenital stationary night blindness (HP:0007642)	3.14337785
9	Abnormality of the renal cortex (HP:0011035)	2.99021005
10	Genetic anticipation (HP:0003743)	2.95471113
11	Medial flaring of the eyebrow (HP:0010747)	2.89621884
12	Congenital sensorineural hearing impairment (HP:0008527)	2.81144367
13	Febrile seizures (HP:0002373)	2.79425211
14	Chronic hepatic failure (HP:0100626)	2.75560497
15	Broad-based gait (HP:0002136)	2.73827938
16	Abnormality of midbrain morphology (HP:0002418)	2.70494223
17	Molar tooth sign on MRI (HP:0002419)	2.70494223
18	Cystic liver disease (HP:0006706)	2.69096435
19	Focal seizures (HP:0007359)	2.67086654
20	Progressive cerebellar ataxia (HP:0002073)	2.64814620
21	Type II lissencephaly (HP:0007260)	2.57392186
22	Nephronophthisis (HP:0000090)	2.56865191
23	Abolished electroretinogram (ERG) (HP:0000550)	2.49512367
24	Gait imbalance (HP:0002141)	2.46946634
25	Clumsiness (HP:0002312)	2.44155371
26	Abnormality of the renal medulla (HP:0100957)	2.42171000
27	Cerebellar dysplasia (HP:0007033)	2.41793698
28	Intestinal atresia (HP:0011100)	2.37851651
29	Congenital primary aphakia (HP:0007707)	2.37473033
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35802747
31	Abnormality of alanine metabolism (HP:0010916)	2.35802747
32	Hyperalaninemia (HP:0003348)	2.35802747
33	Protruding tongue (HP:0010808)	2.35298637
34	Sclerocornea (HP:0000647)	2.33443217
35	Ketoacidosis (HP:0001993)	2.33416605
36	Tubulointerstitial nephritis (HP:0001970)	2.31375783
37	Absent speech (HP:0001344)	2.31259912
38	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.31018525
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.30075016
40	Renal cortical cysts (HP:0000803)	2.28035015
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.27317444
42	Dialeptic seizures (HP:0011146)	2.24332826
43	Thyroiditis (HP:0100646)	2.23852798
44	Subaortic stenosis (HP:0001682)	2.23586185
45	Abnormality of the left ventricular outflow tract (HP:0011103)	2.23586185
46	Nephrogenic diabetes insipidus (HP:0009806)	2.22757974
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.22337723
48	Bony spicule pigmentary retinopathy (HP:0007737)	2.18972350
49	Colon cancer (HP:0003003)	2.18575671
50	Genital tract atresia (HP:0001827)	2.16504633
51	Thyroid-stimulating hormone excess (HP:0002925)	2.16406008
52	Decreased central vision (HP:0007663)	2.16161464
53	Congenital hepatic fibrosis (HP:0002612)	2.09701956
54	Central scotoma (HP:0000603)	2.08763010
55	Ketosis (HP:0001946)	2.07894889
56	Abnormality of the labia minora (HP:0012880)	2.07777152
57	Inability to walk (HP:0002540)	2.07602932
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.05031942
59	Postaxial foot polydactyly (HP:0001830)	2.03648628
60	Constricted visual fields (HP:0001133)	2.02805445
61	Vaginal atresia (HP:0000148)	2.02142008
62	Methylmalonic aciduria (HP:0012120)	2.01358801
63	Increased corneal curvature (HP:0100692)	2.00912887
64	Keratoconus (HP:0000563)	2.00912887
65	Hyperglycinuria (HP:0003108)	1.98973738
66	Furrowed tongue (HP:0000221)	1.97122031
67	Muscle hypertrophy of the lower extremities (HP:0008968)	1.97060429
68	Calf muscle hypertrophy (HP:0008981)	1.94328392
69	Tubular atrophy (HP:0000092)	1.94124849
70	Male pseudohermaphroditism (HP:0000037)	1.92030920
71	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89899272
72	Optic nerve hypoplasia (HP:0000609)	1.87212998
73	Supernumerary spleens (HP:0009799)	1.87102106
74	Absent/shortened dynein arms (HP:0200106)	1.87022907
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.87022907
76	Hypothermia (HP:0002045)	1.86672442
77	Lissencephaly (HP:0001339)	1.86274272
78	Fair hair (HP:0002286)	1.86242172
79	Hypoplastic iliac wings (HP:0002866)	1.84966350
80	Abnormality of B cell number (HP:0010975)	1.84355792
81	Proximal tubulopathy (HP:0000114)	1.82974902
82	Facial diplegia (HP:0001349)	1.82191498
83	Atonic seizures (HP:0010819)	1.81985756
84	Abnormal drinking behavior (HP:0030082)	1.81792479
85	Polydipsia (HP:0001959)	1.81792479
86	Progressive inability to walk (HP:0002505)	1.81078948
87	Poor coordination (HP:0002370)	1.80236642
88	Anencephaly (HP:0002323)	1.80028684
89	Small hand (HP:0200055)	1.79639091
90	Abnormal biliary tract physiology (HP:0012439)	1.79081647
91	Bile duct proliferation (HP:0001408)	1.79081647
92	Long clavicles (HP:0000890)	1.77510483
93	Drooling (HP:0002307)	1.77192427
94	Astigmatism (HP:0000483)	1.76362564
95	Short foot (HP:0001773)	1.75190550
96	Methylmalonic acidemia (HP:0002912)	1.74695439
97	Decreased circulating renin level (HP:0003351)	1.74643134
98	Absence seizures (HP:0002121)	1.73803100
99	Abnormality of glycine metabolism (HP:0010895)	1.73723505
100	Abnormality of serine family amino acid metabolism (HP:0010894)	1.73723505

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.79277294
2	MAP4K2	2.75206184
3	ACVR1B	2.60745339
4	NUAK1	2.53103238
5	BMPR1B	2.52230655
6	WNK3	2.51412997
7	INSRR	2.33007850
8	ADRBK2	2.30285875
9	MAPK13	2.29077201
10	LATS1	2.19224208
11	OBSCN	2.09714368
12	PINK1	2.01558126
13	AKT3	1.88050356
14	CASK	1.81588372
15	PIK3CG	1.74929849
16	STK38L	1.73000312
17	MKNK2	1.70934359
18	GRK1	1.69619111
19	ZAK	1.58614926
20	MAP3K4	1.58534259
21	MUSK	1.57974122
22	PHKG1	1.39861820
23	PHKG2	1.39861820
24	TAOK3	1.34789393
25	MAP3K7	1.33809325
26	MARK1	1.31119191
27	EIF2AK3	1.25838169
28	NEK1	1.25424117
29	BRSK2	1.25036194
30	OXSR1	1.21873932
31	TNIK	1.16570345
32	TRIM28	1.16566748
33	CCNB1	1.11217605
34	STK39	1.10606093
35	PAK3	1.08995070
36	STK3	1.07183045
37	NTRK3	1.00927138
38	WNK4	0.99976050
39	EPHA4	0.97419835
40	PRKCE	0.94695434
41	BCR	0.92412358
42	SGK2	0.92039201
43	PRKAA2	0.91945948
44	PLK2	0.90115117
45	PTK2B	0.88708944
46	PLK4	0.88563653
47	MST4	0.85293213
48	TNK2	0.84667773
49	ERBB3	0.82997012
50	ADRBK1	0.78482107
51	IRAK1	0.74639555
52	CAMK4	0.74487728
53	MKNK1	0.70913410
54	FGFR2	0.62538149
55	DAPK2	0.62385263
56	CDK19	0.62014737
57	CSNK1A1L	0.61784727
58	TRPM7	0.61056521
59	FER	0.60045281
60	EIF2AK1	0.58972561
61	MAP2K7	0.58446914
62	MAPKAPK3	0.57880103
63	CSNK1G1	0.56308925
64	STK11	0.56286748
65	PKN1	0.55776185
66	CAMK2A	0.52202570
67	CSNK1G2	0.51875879
68	PRKAA1	0.50858782
69	CAMKK2	0.50134971
70	PDK2	0.49547573
71	CAMK1	0.49414793
72	WEE1	0.48587213
73	CSNK1G3	0.48300328
74	MARK3	0.47745636
75	PRKCG	0.47580040
76	VRK1	0.47541154
77	PBK	0.43438947
78	TAF1	0.42931667
79	TGFBR1	0.41488064
80	CSNK1D	0.41408610
81	CAMK2D	0.41364596
82	TEC	0.39366795
83	SGK494	0.38976568
84	SGK223	0.38976568
85	PRKACA	0.38550971
86	STK38	0.37904125
87	PRKG1	0.35544743
88	EIF2AK2	0.33211325
89	VRK2	0.31869704
90	BRD4	0.31000809
91	PRKACB	0.30813106
92	CSNK1A1	0.29717748
93	SGK1	0.28959950
94	ATM	0.27720066
95	PLK1	0.26992128
96	BCKDK	0.26763789
97	MAP2K1	0.24709194
98	MAPKAPK5	0.24359630
99	NLK	0.24357497
100	CAMK2B	0.22156870

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.23213890
2	Phototransduction_Homo sapiens_hsa04744	2.64798304
3	Propanoate metabolism_Homo sapiens_hsa00640	2.63059213
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39184564
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.29509821
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.26428079
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.25901461
8	ABC transporters_Homo sapiens_hsa02010	2.18413580
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15931453
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12604645
11	Nicotine addiction_Homo sapiens_hsa05033	2.12011494
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.96714290
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.95243813
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.93937434
15	Homologous recombination_Homo sapiens_hsa03440	1.92609224
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.92368920
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.90191755
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84349239
19	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.83474578
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.80862287
21	Taste transduction_Homo sapiens_hsa04742	1.76681286
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.75974367
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73614930
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.72942802
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.67327328
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.64985070
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.55366454
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.54304372
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.48330558
30	Olfactory transduction_Homo sapiens_hsa04740	1.48275074
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.38956600
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.36179110
33	Retinol metabolism_Homo sapiens_hsa00830	1.29439418
34	Circadian rhythm_Homo sapiens_hsa04710	1.28277556
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21938313
36	Morphine addiction_Homo sapiens_hsa05032	1.19447365
37	Basal transcription factors_Homo sapiens_hsa03022	1.18534764
38	Calcium signaling pathway_Homo sapiens_hsa04020	1.18135418
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.15788337
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15448639
41	Glutamatergic synapse_Homo sapiens_hsa04724	1.14799966
42	Regulation of autophagy_Homo sapiens_hsa04140	1.13037508
43	Fatty acid degradation_Homo sapiens_hsa00071	1.12884326
44	Serotonergic synapse_Homo sapiens_hsa04726	1.11723833
45	Circadian entrainment_Homo sapiens_hsa04713	1.11636334
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09121799
47	Lysine degradation_Homo sapiens_hsa00310	1.05311179
48	Peroxisome_Homo sapiens_hsa04146	1.00583689
49	Caffeine metabolism_Homo sapiens_hsa00232	0.96597936
50	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.96551931
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.96134830
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95573417
53	Insulin secretion_Homo sapiens_hsa04911	0.91914207
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90367667
55	One carbon pool by folate_Homo sapiens_hsa00670	0.87930858
56	Salivary secretion_Homo sapiens_hsa04970	0.87741956
57	GABAergic synapse_Homo sapiens_hsa04727	0.86309885
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84322963
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83245724
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.82961047
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81453520
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.80923715
63	RNA polymerase_Homo sapiens_hsa03020	0.79976874
64	Histidine metabolism_Homo sapiens_hsa00340	0.75470884
65	Purine metabolism_Homo sapiens_hsa00230	0.75060931
66	Protein export_Homo sapiens_hsa03060	0.72201288
67	RNA degradation_Homo sapiens_hsa03018	0.69655805
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66536690
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66245670
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65430023
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.62406721
72	Long-term depression_Homo sapiens_hsa04730	0.60555197
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58066616
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.56379285
75	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.56315925
76	Metabolic pathways_Homo sapiens_hsa01100	0.55709997
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53983254
78	Dopaminergic synapse_Homo sapiens_hsa04728	0.50738269
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48474714
80	Cholinergic synapse_Homo sapiens_hsa04725	0.48071400
81	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.47920731
82	Renin secretion_Homo sapiens_hsa04924	0.47855293
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45371351
84	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.44442165
85	Glutathione metabolism_Homo sapiens_hsa00480	0.44056027
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.42830163
87	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.42722919
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.42629934
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42615112
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42230409
91	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.35058026
92	PPAR signaling pathway_Homo sapiens_hsa03320	0.34761621
93	Cocaine addiction_Homo sapiens_hsa05030	0.32623718
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.31885682
95	Amphetamine addiction_Homo sapiens_hsa05031	0.27853831
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27179456
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.26354332
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.23844112
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.23509831
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23068402

ANKRD20A19P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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