ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	5.61857326
2	cellular ketone body metabolic process (GO:0046950)	4.85456828
3	presynaptic membrane organization (GO:0097090)	4.65138075
4	postsynaptic membrane organization (GO:0001941)	4.57736512
5	ketone body metabolic process (GO:1902224)	4.25402070
6	axon ensheathment in central nervous system (GO:0032291)	4.07569031
7	central nervous system myelination (GO:0022010)	4.07569031
8	startle response (GO:0001964)	4.00350708
9	neurotransmitter-gated ion channel clustering (GO:0072578)	3.94468726
10	nephron tubule morphogenesis (GO:0072078)	3.92786827
11	nephron epithelium morphogenesis (GO:0072088)	3.92786827
12	neuron fate determination (GO:0048664)	3.86933716
13	neuronal action potential propagation (GO:0019227)	3.78235421
14	neuron cell-cell adhesion (GO:0007158)	3.77162040
15	otic vesicle formation (GO:0030916)	3.67705417
16	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.66145555
17	cellular response to leptin stimulus (GO:0044320)	3.51519137
18	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.45962670
19	regulation of timing of cell differentiation (GO:0048505)	3.45268651
20	nonmotile primary cilium assembly (GO:0035058)	3.41059464
21	renal tubule morphogenesis (GO:0061333)	3.40759982
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.40646118
23	high-density lipoprotein particle remodeling (GO:0034375)	3.38511664
24	limb bud formation (GO:0060174)	3.34915431
25	regulation of hexokinase activity (GO:1903299)	3.32802942
26	regulation of glucokinase activity (GO:0033131)	3.32802942
27	negative regulation of astrocyte differentiation (GO:0048712)	3.27552717
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.23369202
29	heme transport (GO:0015886)	3.21603867
30	cochlea development (GO:0090102)	3.20176926
31	regulation of cholesterol esterification (GO:0010872)	3.14372708
32	reverse cholesterol transport (GO:0043691)	3.11759050
33	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.05522150
34	hindbrain development (GO:0030902)	3.04733523
35	vocalization behavior (GO:0071625)	3.02253485
36	epithelial cilium movement (GO:0003351)	3.00378893
37	auditory behavior (GO:0031223)	3.00237575
38	regulation of development, heterochronic (GO:0040034)	2.99834644
39	somite development (GO:0061053)	2.98081700
40	positive regulation of male gonad development (GO:2000020)	2.97661145
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.96687542
42	neuronal action potential (GO:0019228)	2.95653771
43	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.93975082
44	phospholipid efflux (GO:0033700)	2.92128993
45	centriole replication (GO:0007099)	2.90126095
46	negative regulation of glial cell differentiation (GO:0045686)	2.88937553
47	L-fucose catabolic process (GO:0042355)	2.87546084
48	fucose catabolic process (GO:0019317)	2.87546084
49	L-fucose metabolic process (GO:0042354)	2.87546084
50	response to leptin (GO:0044321)	2.85965586
51	resolution of meiotic recombination intermediates (GO:0000712)	2.85058245
52	DNA double-strand break processing (GO:0000729)	2.84799865
53	SMAD protein signal transduction (GO:0060395)	2.82787452
54	regulation of male gonad development (GO:2000018)	2.82509760
55	endocrine pancreas development (GO:0031018)	2.81960055
56	locomotory exploration behavior (GO:0035641)	2.80579879
57	neuronal stem cell maintenance (GO:0097150)	2.77012057
58	serotonin metabolic process (GO:0042428)	2.75140260
59	sperm motility (GO:0030317)	2.73692715
60	iron coordination entity transport (GO:1901678)	2.73400524
61	membrane depolarization during action potential (GO:0086010)	2.71759894
62	parental behavior (GO:0060746)	2.68721899
63	maternal behavior (GO:0042711)	2.68400224
64	sex differentiation (GO:0007548)	2.67107857
65	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.63768234
66	righting reflex (GO:0060013)	2.63189964
67	establishment of protein localization to Golgi (GO:0072600)	2.61776286
68	axon regeneration (GO:0031103)	2.61621947
69	acrosome reaction (GO:0007340)	2.60123789
70	heart valve formation (GO:0003188)	2.59605933
71	mechanosensory behavior (GO:0007638)	2.59593353
72	transmission of nerve impulse (GO:0019226)	2.59309572
73	regulation of cell communication by electrical coupling (GO:0010649)	2.58335955
74	C4-dicarboxylate transport (GO:0015740)	2.56954440
75	protein targeting to Golgi (GO:0000042)	2.55783582
76	axon development (GO:0061564)	2.55579265
77	neurotransmitter uptake (GO:0001504)	2.54778771
78	protein localization to synapse (GO:0035418)	2.54264167
79	negative regulation of Ras GTPase activity (GO:0034261)	2.54220238
80	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.53536079
81	regulation of astrocyte differentiation (GO:0048710)	2.53270107
82	regulation of cilium movement (GO:0003352)	2.52616279
83	positive regulation of meiosis (GO:0045836)	2.52109402
84	inner ear receptor stereocilium organization (GO:0060122)	2.49937548
85	Sertoli cell development (GO:0060009)	2.47997856
86	regulation of protein glycosylation (GO:0060049)	2.47899068
87	cilium movement (GO:0003341)	2.47778913
88	plasma lipoprotein particle assembly (GO:0034377)	2.46982213
89	retinal rod cell development (GO:0046548)	2.46171305
90	primary amino compound metabolic process (GO:1901160)	2.45930613
91	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.45089635
92	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.44334987
93	exploration behavior (GO:0035640)	2.43113394
94	nitric oxide mediated signal transduction (GO:0007263)	2.42933434
95	cranial nerve development (GO:0021545)	2.42817906
96	regulation of synapse structural plasticity (GO:0051823)	2.42600300
97	cAMP-mediated signaling (GO:0019933)	2.42058448
98	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.42028574
99	positive regulation of meiotic cell cycle (GO:0051446)	2.41636478
100	behavioral response to nicotine (GO:0035095)	2.41606379

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.44340284
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.63260568
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.43682899
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.35989291
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.83998459
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.60295211
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58965842
8	AR_21572438_ChIP-Seq_LNCaP_Human	2.57788589
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51633509
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51513234
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.49442601
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.40799295
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.23462535
14	P300_19829295_ChIP-Seq_ESCs_Human	2.23433938
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.23161713
16	VDR_22108803_ChIP-Seq_LS180_Human	2.20272249
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07986265
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06827411
19	* FUS_26573619_Chip-Seq_HEK293_Human	2.05707290
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.90172072
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.88822646
22	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.86677203
23	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86677203
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.86627441
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.86575984
26	EWS_26573619_Chip-Seq_HEK293_Human	1.84343576
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77818532
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.75742035
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74245280
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.71918722
31	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68877607
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.67730804
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.67649113
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64198045
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64042835
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.62453550
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.60438908
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.59808459
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.59808459
40	STAT3_23295773_ChIP-Seq_U87_Human	1.57402922
41	AR_25329375_ChIP-Seq_VCAP_Human	1.55115141
42	TCF4_23295773_ChIP-Seq_U87_Human	1.49949547
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49819158
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45963730
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43891202
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43139587
47	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.41932159
48	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39290567
49	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.38964919
50	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.38605897
51	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35685170
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35144949
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.34047821
54	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.33739458
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.32966438
56	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.31925692
57	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31204111
58	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29831730
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.29247441
60	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.27924333
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24161773
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24161773
63	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.22472658
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.20868118
65	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.20760032
66	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.20101964
67	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.19666557
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19569874
69	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18583105
70	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.18551328
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18091057
72	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.16354125
73	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.15641481
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14339309
75	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.14155691
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13722316
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13181697
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12313730
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11495348
80	RXR_22108803_ChIP-Seq_LS180_Human	1.11313468
81	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.10348239
82	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09426232
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09297848
84	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.07572057
85	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.07062837
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07059686
87	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05518665
88	TBL1_22424771_ChIP-Seq_293T_Human	1.04265889
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03231866
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02856856
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02837456
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02287687
93	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.01912482
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98735492
95	GATA1_22025678_ChIP-Seq_K562_Human	0.98230838
96	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97676187
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96610642
98	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.96149000
99	SOX9_26525672_Chip-Seq_HEART_Mouse	0.95802589
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95682558

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.44417325
2	MP0000569_abnormal_digit_pigmentation	4.33376866
3	MP0003136_yellow_coat_color	3.17682864
4	MP0001986_abnormal_taste_sensitivity	2.59257735
5	MP0002928_abnormal_bile_duct	2.53012418
6	MP0005084_abnormal_gallbladder_morpholo	2.51693408
7	MP0001486_abnormal_startle_reflex	2.46743067
8	MP0004859_abnormal_synaptic_plasticity	2.21248394
9	MP0008877_abnormal_DNA_methylation	2.15188531
10	MP0005410_abnormal_fertilization	2.10682852
11	MP0009745_abnormal_behavioral_response	2.09282947
12	MP0005646_abnormal_pituitary_gland	2.06636840
13	MP0002064_seizures	2.01483505
14	MP0001968_abnormal_touch/_nociception	1.99937295
15	MP0001984_abnormal_olfaction	1.98616214
16	MP0004885_abnormal_endolymph	1.94036515
17	MP0002272_abnormal_nervous_system	1.93258598
18	MP0006276_abnormal_autonomic_nervous	1.90360918
19	MP0001529_abnormal_vocalization	1.89139234
20	MP0005551_abnormal_eye_electrophysiolog	1.88041414
21	MP0003635_abnormal_synaptic_transmissio	1.87360916
22	MP0000778_abnormal_nervous_system	1.85725174
23	MP0003787_abnormal_imprinting	1.83650208
24	MP0002653_abnormal_ependyma_morphology	1.82939031
25	MP0002736_abnormal_nociception_after	1.82157771
26	MP0003283_abnormal_digestive_organ	1.80557685
27	MP0002572_abnormal_emotion/affect_behav	1.75648683
28	MP0009046_muscle_twitch	1.63785525
29	MP0005423_abnormal_somatic_nervous	1.63583566
30	MP0002938_white_spotting	1.59334025
31	MP0002734_abnormal_mechanical_nocicepti	1.57749333
32	MP0002067_abnormal_sensory_capabilities	1.55402275
33	MP0003122_maternal_imprinting	1.51358077
34	MP0004270_analgesia	1.50691059
35	MP0002557_abnormal_social/conspecific_i	1.47932783
36	MP0004043_abnormal_pH_regulation	1.46130851
37	MP0003633_abnormal_nervous_system	1.45958383
38	MP0002063_abnormal_learning/memory/cond	1.45561786
39	MP0002102_abnormal_ear_morphology	1.45202205
40	MP0002638_abnormal_pupillary_reflex	1.44881567
41	MP0002090_abnormal_vision	1.44399805
42	MP0001440_abnormal_grooming_behavior	1.37460233
43	MP0000631_abnormal_neuroendocrine_gland	1.34095941
44	MP0001485_abnormal_pinna_reflex	1.31353520
45	MP0005174_abnormal_tail_pigmentation	1.30836834
46	MP0000566_synostosis	1.28406084
47	MP0004142_abnormal_muscle_tone	1.27831630
48	MP0001905_abnormal_dopamine_level	1.25264157
49	MP0003698_abnormal_male_reproductive	1.21112462
50	MP0000026_abnormal_inner_ear	1.17821219
51	MP0001970_abnormal_pain_threshold	1.15471998
52	MP0001929_abnormal_gametogenesis	1.14813246
53	MP0004133_heterotaxia	1.14361508
54	MP0004147_increased_porphyrin_level	1.13682777
55	MP0004742_abnormal_vestibular_system	1.12731744
56	MP0006072_abnormal_retinal_apoptosis	1.11265448
57	MP0000647_abnormal_sebaceous_gland	1.10690880
58	MP0003121_genomic_imprinting	1.09853183
59	MP0003631_nervous_system_phenotype	1.09136532
60	MP0008058_abnormal_DNA_repair	1.08772785
61	MP0001963_abnormal_hearing_physiology	1.07036577
62	MP0000955_abnormal_spinal_cord	1.07009235
63	MP0010329_abnormal_lipoprotein_level	1.03816812
64	MP0000427_abnormal_hair_cycle	1.00663059
65	MP0000538_abnormal_urinary_bladder	0.99188038
66	MP0005253_abnormal_eye_physiology	0.97231349
67	MP0005386_behavior/neurological_phenoty	0.97168962
68	MP0004924_abnormal_behavior	0.97168962
69	MP0009840_abnormal_foam_cell	0.95869595
70	MP0010386_abnormal_urinary_bladder	0.95653909
71	MP0002882_abnormal_neuron_morphology	0.93341531
72	MP0002095_abnormal_skin_pigmentation	0.93090198
73	MP0009780_abnormal_chondrocyte_physiolo	0.92572246
74	MP0000534_abnormal_ureter_morphology	0.91679176
75	MP0001501_abnormal_sleep_pattern	0.91569743
76	MP0002735_abnormal_chemical_nociception	0.91505366
77	MP0001286_abnormal_eye_development	0.91492171
78	MP0001944_abnormal_pancreas_morphology	0.89706831
79	MP0008872_abnormal_physiological_respon	0.89649619
80	MP0005367_renal/urinary_system_phenotyp	0.89502788
81	MP0000516_abnormal_urinary_system	0.89502788
82	MP0003252_abnormal_bile_duct	0.89012870
83	MP0002152_abnormal_brain_morphology	0.88664175
84	MP0002234_abnormal_pharynx_morphology	0.86194206
85	MP0001299_abnormal_eye_distance/	0.85507231
86	MP0002184_abnormal_innervation	0.84993099
87	MP0002233_abnormal_nose_morphology	0.84014653
88	MP0003890_abnormal_embryonic-extraembry	0.83205440
89	MP0002752_abnormal_somatic_nervous	0.83099306
90	MP0004215_abnormal_myocardial_fiber	0.81467486
91	MP0002229_neurodegeneration	0.81366592
92	MP0008569_lethality_at_weaning	0.80798045
93	MP0002066_abnormal_motor_capabilities/c	0.80790369
94	MP0005085_abnormal_gallbladder_physiolo	0.76672287
95	MP0005195_abnormal_posterior_eye	0.76128364
96	MP0006292_abnormal_olfactory_placode	0.75940686
97	MP0003634_abnormal_glial_cell	0.75176048
98	MP0003937_abnormal_limbs/digits/tail_de	0.73762984
99	MP0000920_abnormal_myelination	0.73128856
100	MP0003632_abnormal_nervous_system	0.72656050

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cerebellar dysplasia (HP:0007033)	4.39083587
2	Calf muscle hypertrophy (HP:0008981)	4.27209213
3	Type II lissencephaly (HP:0007260)	3.95576012
4	Focal motor seizures (HP:0011153)	3.95295792
5	Muscle hypertrophy of the lower extremities (HP:0008968)	3.67771591
6	Intestinal atresia (HP:0011100)	3.51506631
7	Chronic hepatic failure (HP:0100626)	3.35820246
8	Atonic seizures (HP:0010819)	3.31377224
9	Spontaneous abortion (HP:0005268)	3.29955556
10	Hemiparesis (HP:0001269)	3.16817190
11	Hyperventilation (HP:0002883)	3.16392195
12	Abnormality of the pons (HP:0007361)	3.11878950
13	Febrile seizures (HP:0002373)	3.11611118
14	Hypoplasia of the pons (HP:0012110)	2.99289127
15	Gastrointestinal atresia (HP:0002589)	2.95929364
16	True hermaphroditism (HP:0010459)	2.95813448
17	Concave nail (HP:0001598)	2.88249890
18	Split foot (HP:0001839)	2.86378061
19	Retinal atrophy (HP:0001105)	2.81666837
20	Focal seizures (HP:0007359)	2.79685224
21	Epileptic encephalopathy (HP:0200134)	2.66203320
22	Pancreatic cysts (HP:0001737)	2.62976217
23	Medial flaring of the eyebrow (HP:0010747)	2.58615428
24	Sex reversal (HP:0012245)	2.49781604
25	Abnormal sex determination (HP:0012244)	2.49781604
26	Pancreatic fibrosis (HP:0100732)	2.48972862
27	Absence seizures (HP:0002121)	2.46252503
28	Dialeptic seizures (HP:0011146)	2.34517186
29	Molar tooth sign on MRI (HP:0002419)	2.29443187
30	Abnormality of midbrain morphology (HP:0002418)	2.29443187
31	Hemiplegia (HP:0002301)	2.27895792
32	Gait imbalance (HP:0002141)	2.21003545
33	Oligodactyly (hands) (HP:0001180)	2.17345721
34	Epileptiform EEG discharges (HP:0011182)	2.17337082
35	Progressive macrocephaly (HP:0004481)	2.17003876
36	Intrahepatic cholestasis (HP:0001406)	2.14997498
37	Abnormality of the labia minora (HP:0012880)	2.10569605
38	Acute necrotizing encephalopathy (HP:0006965)	2.10123299
39	Esophageal atresia (HP:0002032)	2.09651485
40	Large for gestational age (HP:0001520)	2.05112610
41	Megalencephaly (HP:0001355)	2.03559606
42	Median cleft lip (HP:0000161)	2.03355818
43	EEG with generalized epileptiform discharges (HP:0011198)	2.02570937
44	Abnormal drinking behavior (HP:0030082)	2.01475040
45	Polydipsia (HP:0001959)	2.01475040
46	Hypoglycemic seizures (HP:0002173)	2.01048846
47	Congenital primary aphakia (HP:0007707)	2.00225120
48	Hypomagnesemia (HP:0002917)	1.99817968
49	Male pseudohermaphroditism (HP:0000037)	1.99371759
50	Hypsarrhythmia (HP:0002521)	1.98152289
51	Tubulointerstitial nephritis (HP:0001970)	1.97009470
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.94594226
53	Abnormality of alanine metabolism (HP:0010916)	1.94594226
54	Hyperalaninemia (HP:0003348)	1.94594226
55	Progressive cerebellar ataxia (HP:0002073)	1.92280725
56	Hypothermia (HP:0002045)	1.91505209
57	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.88359055
58	Hypoglycemic coma (HP:0001325)	1.87039274
59	Nephronophthisis (HP:0000090)	1.86808115
60	Fair hair (HP:0002286)	1.86697555
61	Abnormality of the renal cortex (HP:0011035)	1.86045580
62	Gaze-evoked nystagmus (HP:0000640)	1.85701971
63	Renal cortical cysts (HP:0000803)	1.84750819
64	Genital tract atresia (HP:0001827)	1.84621519
65	Acute encephalopathy (HP:0006846)	1.83918032
66	Ankle clonus (HP:0011448)	1.82729981
67	Steatorrhea (HP:0002570)	1.81991827
68	Generalized tonic-clonic seizures (HP:0002069)	1.81185485
69	Ketoacidosis (HP:0001993)	1.78620627
70	Vaginal atresia (HP:0000148)	1.77001450
71	Abnormality of the diencephalon (HP:0010662)	1.76873063
72	Intellectual disability, profound (HP:0002187)	1.76268842
73	Methylmalonic acidemia (HP:0002912)	1.76104799
74	Abnormality of the renal medulla (HP:0100957)	1.72838261
75	Neoplasm of the oral cavity (HP:0100649)	1.69311947
76	Nephrogenic diabetes insipidus (HP:0009806)	1.67331808
77	Abnormal biliary tract physiology (HP:0012439)	1.67238027
78	Bile duct proliferation (HP:0001408)	1.67238027
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.67207605
80	Increased circulating renin level (HP:0000848)	1.65415536
81	Poor coordination (HP:0002370)	1.65098808
82	Hypobetalipoproteinemia (HP:0003563)	1.64680840
83	Fat malabsorption (HP:0002630)	1.64250664
84	Posterior subcapsular cataract (HP:0007787)	1.63846681
85	Glioma (HP:0009733)	1.62840125
86	Specific learning disability (HP:0001328)	1.62153457
87	Scrotal hypoplasia (HP:0000046)	1.61843884
88	Postaxial hand polydactyly (HP:0001162)	1.61208764
89	Hyperinsulinemic hypoglycemia (HP:0000825)	1.60818092
90	Abnormal mitochondria in muscle tissue (HP:0008316)	1.60214610
91	Rectal fistula (HP:0100590)	1.59838023
92	Rectovaginal fistula (HP:0000143)	1.59838023
93	Cystic liver disease (HP:0006706)	1.59355825
94	Abnormality of vitamin B metabolism (HP:0004340)	1.58680807
95	Bifid scrotum (HP:0000048)	1.56575652
96	Shoulder girdle muscle weakness (HP:0003547)	1.56118027
97	Amblyopia (HP:0000646)	1.54575329
98	Broad-based gait (HP:0002136)	1.53630311
99	Polyphagia (HP:0002591)	1.53010823
100	Increased corneal curvature (HP:0100692)	1.52419584

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	6.01264868
2	PNCK	5.33377880
3	FRK	3.92714186
4	TRIM28	3.17308593
5	NTRK3	2.99330599
6	PINK1	2.89447693
7	PDK2	2.76452414
8	WEE1	2.59937058
9	CCNB1	2.43738285
10	MKNK2	2.22811238
11	TNIK	2.20832254
12	MAPK13	2.17847805
13	WNK3	2.15340531
14	VRK1	1.96897508
15	TSSK6	1.82760026
16	EPHA4	1.79582559
17	CDK3	1.68133177
18	NTRK2	1.61407300
19	MAP4K2	1.61126003
20	FGFR2	1.55210905
21	TAOK3	1.52867958
22	PLK2	1.50637289
23	NUAK1	1.47452981
24	CASK	1.45430715
25	MARK1	1.38160873
26	PAK6	1.30618538
27	BMPR1B	1.30006452
28	BMPR2	1.25098540
29	PLK3	1.07541574
30	PLK4	1.02466172
31	MAPKAPK3	1.00060686
32	MAP3K12	0.97275060
33	PKN1	0.96235887
34	ERBB3	0.95170587
35	DMPK	0.92143037
36	ZAK	0.92101889
37	MKNK1	0.91898125
38	PRKCG	0.91672386
39	TNK2	0.91228054
40	ACVR1B	0.89385186
41	PAK3	0.88946653
42	PBK	0.87760278
43	MAP3K4	0.84681463
44	INSRR	0.81040306
45	MAP3K2	0.76844275
46	PHKG1	0.76589392
47	PHKG2	0.76589392
48	ADRBK2	0.74293344
49	CAMK1G	0.70661616
50	GRK1	0.70168373
51	CSNK1G2	0.68113120
52	MINK1	0.62585711
53	PAK2	0.62573797
54	PTK2B	0.58868131
55	AKT3	0.57118194
56	CAMK2A	0.56447338
57	DYRK1A	0.51423808
58	SGK2	0.49997632
59	GRK5	0.48939892
60	ROCK1	0.48358038
61	WNK4	0.45853487
62	PRKG1	0.44930619
63	MAPKAPK5	0.44497297
64	CAMK2D	0.42157612
65	PRKCE	0.41856165
66	ERBB4	0.41143802
67	CSNK1A1	0.40837138
68	LATS1	0.39878239
69	SGK1	0.38730946
70	TLK1	0.38303978
71	CSNK1G1	0.37806110
72	UHMK1	0.37790949
73	CAMK1	0.37522286
74	RIPK4	0.35951424
75	SGK223	0.35897148
76	SGK494	0.35897148
77	PRKD3	0.34041249
78	OXSR1	0.31786090
79	GSK3A	0.31261651
80	CSNK1E	0.30217295
81	CDK19	0.29863236
82	PRKACB	0.29682621
83	MARK3	0.28840993
84	CDK5	0.28548152
85	RPS6KA5	0.28368353
86	RPS6KA3	0.27629817
87	PDK1	0.25487812
88	CSNK1G3	0.25329080
89	PRKCZ	0.25216081
90	CAMK1D	0.24185032
91	PRKACA	0.24073341
92	CSNK1D	0.23710756
93	STK39	0.23004526
94	CSNK2A2	0.22982856
95	MAP2K7	0.22820426
96	CSNK1A1L	0.22686139
97	ATM	0.22677299
98	PRKCB	0.22371464
99	NEK6	0.20573196
100	GSK3B	0.20456860

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.58824880
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.21935801
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.28077559
4	Butanoate metabolism_Homo sapiens_hsa00650	2.68073977
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.65377682
6	Nicotine addiction_Homo sapiens_hsa05033	2.56299605
7	Insulin secretion_Homo sapiens_hsa04911	2.14489919
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.11974088
9	Propanoate metabolism_Homo sapiens_hsa00640	2.02625629
10	Amphetamine addiction_Homo sapiens_hsa05031	1.87653190
11	Circadian entrainment_Homo sapiens_hsa04713	1.74672618
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72250305
13	Taste transduction_Homo sapiens_hsa04742	1.70628144
14	Protein export_Homo sapiens_hsa03060	1.61517292
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.57789244
16	Regulation of autophagy_Homo sapiens_hsa04140	1.51144256
17	Cocaine addiction_Homo sapiens_hsa05030	1.50453918
18	Fat digestion and absorption_Homo sapiens_hsa04975	1.48269062
19	Phototransduction_Homo sapiens_hsa04744	1.46314135
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45491437
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.43024988
22	Fatty acid elongation_Homo sapiens_hsa00062	1.42717397
23	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.42543857
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.42502987
25	Peroxisome_Homo sapiens_hsa04146	1.40336430
26	Olfactory transduction_Homo sapiens_hsa04740	1.36621536
27	GABAergic synapse_Homo sapiens_hsa04727	1.35067938
28	PPAR signaling pathway_Homo sapiens_hsa03320	1.34717244
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25696071
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.25109436
31	Morphine addiction_Homo sapiens_hsa05032	1.20346159
32	Dopaminergic synapse_Homo sapiens_hsa04728	1.19962621
33	Salivary secretion_Homo sapiens_hsa04970	1.19798448
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.12032085
35	Caffeine metabolism_Homo sapiens_hsa00232	1.08333144
36	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.08294424
37	Gastric acid secretion_Homo sapiens_hsa04971	1.08043813
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07359378
39	Parkinsons disease_Homo sapiens_hsa05012	1.06003071
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.03891553
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.03267394
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.03165375
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99585173
44	Fatty acid metabolism_Homo sapiens_hsa01212	0.99057410
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95549274
46	cAMP signaling pathway_Homo sapiens_hsa04024	0.94231659
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.92825463
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.92257289
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87840623
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87150067
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85150116
52	Calcium signaling pathway_Homo sapiens_hsa04020	0.85033667
53	Serotonergic synapse_Homo sapiens_hsa04726	0.84731174
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.81216128
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80675951
56	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.78275670
57	Renin secretion_Homo sapiens_hsa04924	0.77592851
58	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77012123
59	ABC transporters_Homo sapiens_hsa02010	0.76848782
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.76249524
61	Oocyte meiosis_Homo sapiens_hsa04114	0.74672726
62	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.74126812
63	Estrogen signaling pathway_Homo sapiens_hsa04915	0.70987652
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.70488557
65	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.70426265
66	Cholinergic synapse_Homo sapiens_hsa04725	0.69203021
67	Fatty acid degradation_Homo sapiens_hsa00071	0.68692029
68	Long-term depression_Homo sapiens_hsa04730	0.67228148
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67203852
70	Alzheimers disease_Homo sapiens_hsa05010	0.66936170
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.66928807
72	Homologous recombination_Homo sapiens_hsa03440	0.66063951
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.65696001
74	Glutathione metabolism_Homo sapiens_hsa00480	0.64757100
75	Long-term potentiation_Homo sapiens_hsa04720	0.64518531
76	Folate biosynthesis_Homo sapiens_hsa00790	0.63469732
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.61176092
78	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.58088021
79	Huntingtons disease_Homo sapiens_hsa05016	0.56339957
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56218616
81	Gap junction_Homo sapiens_hsa04540	0.55036392
82	Arginine biosynthesis_Homo sapiens_hsa00220	0.54332216
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52553780
84	Type II diabetes mellitus_Homo sapiens_hsa04930	0.52443510
85	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52213614
86	Pancreatic secretion_Homo sapiens_hsa04972	0.51415926
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50777523
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50637550
89	Basal transcription factors_Homo sapiens_hsa03022	0.48928545
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48180711
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43321741
92	Non-homologous end-joining_Homo sapiens_hsa03450	0.42356721
93	Retinol metabolism_Homo sapiens_hsa00830	0.41742315
94	Mineral absorption_Homo sapiens_hsa04978	0.40851777
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.40815975
96	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.39700357
97	Asthma_Homo sapiens_hsa05310	0.39225866
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.37500880
99	Bile secretion_Homo sapiens_hsa04976	0.36623409
100	Glucagon signaling pathway_Homo sapiens_hsa04922	0.34211252

ANKRD20A2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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