ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.87461892
2	tryptophan catabolic process (GO:0006569)	4.59005240
3	indole-containing compound catabolic process (GO:0042436)	4.59005240
4	indolalkylamine catabolic process (GO:0046218)	4.59005240
5	indolalkylamine metabolic process (GO:0006586)	4.35410564
6	synapsis (GO:0007129)	4.25912972
7	kynurenine metabolic process (GO:0070189)	4.24951068
8	gamma-aminobutyric acid transport (GO:0015812)	3.95377200
9	behavioral response to nicotine (GO:0035095)	3.90499677
10	signal peptide processing (GO:0006465)	3.88040895
11	tryptophan metabolic process (GO:0006568)	3.85671610
12	cellular ketone body metabolic process (GO:0046950)	3.81252770
13	piRNA metabolic process (GO:0034587)	3.64106415
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.61394995
15	detection of light stimulus involved in visual perception (GO:0050908)	3.61394995
16	photoreceptor cell maintenance (GO:0045494)	3.59518840
17	ketone body metabolic process (GO:1902224)	3.58318212
18	indole-containing compound metabolic process (GO:0042430)	3.49042633
19	startle response (GO:0001964)	3.47464384
20	DNA methylation involved in gamete generation (GO:0043046)	3.47253018
21	cilium or flagellum-dependent cell motility (GO:0001539)	3.42992451
22	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.42382839
23	sulfation (GO:0051923)	3.41649901
24	auditory receptor cell stereocilium organization (GO:0060088)	3.39787776
25	regulation of meiosis I (GO:0060631)	3.37155299
26	reflex (GO:0060004)	3.26670852
27	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.23076759
28	male meiosis (GO:0007140)	3.22794883
29	regulation of cilium movement (GO:0003352)	3.20472126
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.14925853
31	monoubiquitinated protein deubiquitination (GO:0035520)	3.10444673
32	L-fucose catabolic process (GO:0042355)	3.09974973
33	fucose catabolic process (GO:0019317)	3.09974973
34	L-fucose metabolic process (GO:0042354)	3.09974973
35	serotonin metabolic process (GO:0042428)	3.09855074
36	behavioral response to ethanol (GO:0048149)	3.08327675
37	centriole replication (GO:0007099)	3.07826377
38	response to pheromone (GO:0019236)	3.04005946
39	reciprocal DNA recombination (GO:0035825)	3.03294645
40	reciprocal meiotic recombination (GO:0007131)	3.03294645
41	neuronal action potential (GO:0019228)	2.94319018
42	male meiosis I (GO:0007141)	2.93354487
43	chromosome organization involved in meiosis (GO:0070192)	2.92181718
44	meiotic chromosome segregation (GO:0045132)	2.91118434
45	righting reflex (GO:0060013)	2.89189924
46	amine catabolic process (GO:0009310)	2.82120626
47	cellular biogenic amine catabolic process (GO:0042402)	2.82120626
48	aromatic amino acid family catabolic process (GO:0009074)	2.82109037
49	interkinetic nuclear migration (GO:0022027)	2.81562246
50	positive regulation of meiosis (GO:0045836)	2.81074810
51	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.80991568
52	benzene-containing compound metabolic process (GO:0042537)	2.80688841
53	nonmotile primary cilium assembly (GO:0035058)	2.77880088
54	oxidative demethylation (GO:0070989)	2.77103773
55	transmission of nerve impulse (GO:0019226)	2.76748505
56	resolution of meiotic recombination intermediates (GO:0000712)	2.76485045
57	membrane depolarization during action potential (GO:0086010)	2.74092192
58	recombinational repair (GO:0000725)	2.71900581
59	establishment of protein localization to Golgi (GO:0072600)	2.71605336
60	glutamate receptor signaling pathway (GO:0007215)	2.71211273
61	double-strand break repair via homologous recombination (GO:0000724)	2.70988826
62	inner ear receptor stereocilium organization (GO:0060122)	2.69952775
63	regulation of hippo signaling (GO:0035330)	2.69599981
64	axoneme assembly (GO:0035082)	2.69495291
65	cilium organization (GO:0044782)	2.69267672
66	protein K11-linked deubiquitination (GO:0035871)	2.66305824
67	dopamine transport (GO:0015872)	2.65325249
68	cilium morphogenesis (GO:0060271)	2.65311021
69	cilium assembly (GO:0042384)	2.64926126
70	proline transport (GO:0015824)	2.64720778
71	primary amino compound metabolic process (GO:1901160)	2.64441648
72	neural tube formation (GO:0001841)	2.63541320
73	positive regulation of meiotic cell cycle (GO:0051446)	2.62300417
74	presynaptic membrane assembly (GO:0097105)	2.61033873
75	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.59299246
76	aromatic amino acid family metabolic process (GO:0009072)	2.57976689
77	anterograde synaptic vesicle transport (GO:0048490)	2.57093330
78	sensory perception of smell (GO:0007608)	2.56591594
79	replication fork processing (GO:0031297)	2.55887690
80	multicellular organism reproduction (GO:0032504)	2.52724449
81	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.51060472
82	retinal cone cell development (GO:0046549)	2.50085930
83	protein polyglutamylation (GO:0018095)	2.47748693
84	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.47327040
85	NAD biosynthetic process (GO:0009435)	2.46426547
86	epithelial cilium movement (GO:0003351)	2.45945476
87	thyroid hormone metabolic process (GO:0042403)	2.45193483
88	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.43469808
89	synaptic transmission, glutamatergic (GO:0035249)	2.42121253
90	neuron cell-cell adhesion (GO:0007158)	2.41569720
91	cellular response to sterol (GO:0036315)	2.39967213
92	regulation of sarcomere organization (GO:0060297)	2.36775831
93	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.33638576
94	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.33638576
95	sperm motility (GO:0030317)	2.33503390
96	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.33364933
97	positive regulation of glycolytic process (GO:0045821)	2.33162540
98	methionine biosynthetic process (GO:0009086)	2.32589750
99	microtubule anchoring (GO:0034453)	2.31549497
100	postsynaptic membrane organization (GO:0001941)	2.29817347

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.70495350
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.43147744
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.18662435
4	VDR_22108803_ChIP-Seq_LS180_Human	3.13326221
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.08101324
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.91972895
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.81476002
8	* ZNF274_21170338_ChIP-Seq_K562_Hela	2.79731441
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75057256
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.66691605
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.31985194
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.27054376
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.22718479
14	FUS_26573619_Chip-Seq_HEK293_Human	2.19995589
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.17893277
16	P300_19829295_ChIP-Seq_ESCs_Human	2.17132531
17	EWS_26573619_Chip-Seq_HEK293_Human	2.14617742
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.11056986
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03242895
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.01510684
21	STAT3_23295773_ChIP-Seq_U87_Human	1.92139400
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.91818233
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.83709015
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.77643715
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.77403100
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71337147
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.70494942
28	TCF4_23295773_ChIP-Seq_U87_Human	1.69919800
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.69443099
30	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.65840153
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61761812
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61698963
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.61698963
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.60854303
35	AR_25329375_ChIP-Seq_VCAP_Human	1.60437865
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.59597404
37	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.50287845
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49779526
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49576757
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46224035
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.46028176
42	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45138630
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43613447
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43613447
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.42476857
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42245169
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41686398
48	RUNX2_22187159_ChIP-Seq_PCA_Human	1.41509571
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40403164
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34060958
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33644844
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32582086
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.32069902
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30370570
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29109189
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29109189
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.29041648
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27581073
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27472586
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.26598697
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23189954
62	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21487278
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20395039
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20323594
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20258304
66	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19492243
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.18857649
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18818529
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.18755289
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18066236
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14451393
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13690867
73	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.13688396
74	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12119280
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10992322
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10659934
77	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09816818
78	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.08780059
79	TP53_16413492_ChIP-PET_HCT116_Human	1.08148612
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08120815
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07720090
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06536321
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05919240
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05919240
85	RXR_22108803_ChIP-Seq_LS180_Human	1.04283699
86	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.03772546
87	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03524429
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02811342
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02224949
90	TBL1_22424771_ChIP-Seq_293T_Human	1.02160280
91	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.00869588
92	JUN_21703547_ChIP-Seq_K562_Human	1.00772343
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00316274
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99980005
95	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.99504559
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99258118
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98834375
98	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98272650
99	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.96464218
100	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95475360

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.24287208
2	MP0003195_calcinosis	3.11061702
3	MP0008877_abnormal_DNA_methylation	2.66402553
4	MP0002736_abnormal_nociception_after	2.62521073
5	MP0001968_abnormal_touch/_nociception	2.55028888
6	MP0000372_irregular_coat_pigmentation	2.54294623
7	MP0000569_abnormal_digit_pigmentation	2.51522679
8	MP0005551_abnormal_eye_electrophysiolog	2.48347590
9	MP0001485_abnormal_pinna_reflex	2.37633303
10	MP0009046_muscle_twitch	2.29856405
11	MP0005171_absent_coat_pigmentation	2.17514120
12	MP0008057_abnormal_DNA_replication	2.05056437
13	MP0001501_abnormal_sleep_pattern	1.96558580
14	MP0009745_abnormal_behavioral_response	1.92436116
15	MP0003646_muscle_fatigue	1.92123201
16	MP0004885_abnormal_endolymph	1.91828967
17	MP0005646_abnormal_pituitary_gland	1.87566289
18	MP0004043_abnormal_pH_regulation	1.86021186
19	MP0004147_increased_porphyrin_level	1.85729695
20	MP0005174_abnormal_tail_pigmentation	1.83625404
21	MP0002272_abnormal_nervous_system	1.76902850
22	MP0002102_abnormal_ear_morphology	1.74709660
23	MP0000427_abnormal_hair_cycle	1.72198856
24	MP0006276_abnormal_autonomic_nervous	1.66444814
25	MP0000631_abnormal_neuroendocrine_gland	1.62914624
26	MP0002837_dystrophic_cardiac_calcinosis	1.60916174
27	MP0005253_abnormal_eye_physiology	1.60401073
28	MP0005410_abnormal_fertilization	1.59594098
29	MP0001486_abnormal_startle_reflex	1.59395805
30	MP0008872_abnormal_physiological_respon	1.56851544
31	MP0002638_abnormal_pupillary_reflex	1.48059092
32	MP0010386_abnormal_urinary_bladder	1.47340183
33	MP0004142_abnormal_muscle_tone	1.44744542
34	MP0002938_white_spotting	1.42391531
35	MP0002064_seizures	1.40658168
36	MP0008058_abnormal_DNA_repair	1.40203263
37	MP0003718_maternal_effect	1.35211977
38	MP0003698_abnormal_male_reproductive	1.35206109
39	MP0001986_abnormal_taste_sensitivity	1.33658457
40	MP0002572_abnormal_emotion/affect_behav	1.33501265
41	MP0001929_abnormal_gametogenesis	1.32309862
42	MP0002067_abnormal_sensory_capabilities	1.31257666
43	MP0003635_abnormal_synaptic_transmissio	1.30463406
44	MP0006072_abnormal_retinal_apoptosis	1.29215890
45	MP0002160_abnormal_reproductive_system	1.27785908
46	MP0005377_hearing/vestibular/ear_phenot	1.26444413
47	MP0003878_abnormal_ear_physiology	1.26444413
48	MP0002735_abnormal_chemical_nociception	1.25192240
49	MP0002095_abnormal_skin_pigmentation	1.23628328
50	MP0001970_abnormal_pain_threshold	1.23377060
51	MP0002876_abnormal_thyroid_physiology	1.22895690
52	MP0002210_abnormal_sex_determination	1.22053510
53	MP0002557_abnormal_social/conspecific_i	1.20524731
54	MP0009780_abnormal_chondrocyte_physiolo	1.20061831
55	MP0004742_abnormal_vestibular_system	1.17754030
56	MP0003950_abnormal_plasma_membrane	1.17695357
57	MP0005085_abnormal_gallbladder_physiolo	1.14715564
58	MP0004215_abnormal_myocardial_fiber	1.14257545
59	MP0006292_abnormal_olfactory_placode	1.13194655
60	MP0005645_abnormal_hypothalamus_physiol	1.12922976
61	MP0002734_abnormal_mechanical_nocicepti	1.07181381
62	MP0002733_abnormal_thermal_nociception	1.07025774
63	MP0002063_abnormal_learning/memory/cond	1.06921621
64	MP0001984_abnormal_olfaction	1.06732769
65	MP0002928_abnormal_bile_duct	1.05697429
66	MP0005386_behavior/neurological_phenoty	1.04446506
67	MP0004924_abnormal_behavior	1.04446506
68	MP0005187_abnormal_penis_morphology	1.04135284
69	MP0002229_neurodegeneration	1.01806611
70	MP0004145_abnormal_muscle_electrophysio	1.01474051
71	MP0001963_abnormal_hearing_physiology	1.00387021
72	MP0000230_abnormal_systemic_arterial	0.99740827
73	MP0003787_abnormal_imprinting	0.97732356
74	MP0003880_abnormal_central_pattern	0.96836836
75	MP0002090_abnormal_vision	0.96826127
76	MP0005389_reproductive_system_phenotype	0.96675762
77	MP0008995_early_reproductive_senescence	0.95463247
78	MP0000653_abnormal_sex_gland	0.93622689
79	MP0000647_abnormal_sebaceous_gland	0.92320344
80	MP0001145_abnormal_male_reproductive	0.90623338
81	MP0003879_abnormal_hair_cell	0.89659169
82	MP0000383_abnormal_hair_follicle	0.89533173
83	MP0001529_abnormal_vocalization	0.86947735
84	MP0000026_abnormal_inner_ear	0.86234392
85	MP0002909_abnormal_adrenal_gland	0.84857607
86	MP0010094_abnormal_chromosome_stability	0.84830609
87	MP0008875_abnormal_xenobiotic_pharmacok	0.84587388
88	MP0004085_abnormal_heartbeat	0.83914116
89	MP0005195_abnormal_posterior_eye	0.80672018
90	MP0003633_abnormal_nervous_system	0.79758467
91	MP0003252_abnormal_bile_duct	0.79616451
92	MP0000538_abnormal_urinary_bladder	0.78810885
93	MP0009697_abnormal_copulation	0.76719966
94	MP0001324_abnormal_eye_pigmentation	0.76149694
95	MP0010329_abnormal_lipoprotein_level	0.75639090
96	MP0002138_abnormal_hepatobiliary_system	0.74108060
97	MP0003137_abnormal_impulse_conducting	0.73034009
98	MP0002882_abnormal_neuron_morphology	0.71464731
99	MP0005395_other_phenotype	0.70998262
100	MP0002234_abnormal_pharynx_morphology	0.70515396

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.47069446
2	Pancreatic cysts (HP:0001737)	4.26458661
3	Pancreatic fibrosis (HP:0100732)	4.13904946
4	True hermaphroditism (HP:0010459)	4.06497266
5	Gaze-evoked nystagmus (HP:0000640)	3.57443064
6	Congenital stationary night blindness (HP:0007642)	3.51415760
7	Molar tooth sign on MRI (HP:0002419)	3.51200107
8	Abnormality of midbrain morphology (HP:0002418)	3.51200107
9	Attenuation of retinal blood vessels (HP:0007843)	3.17211939
10	Congenital sensorineural hearing impairment (HP:0008527)	3.11835714
11	Progressive cerebellar ataxia (HP:0002073)	3.00598597
12	Large for gestational age (HP:0001520)	2.95453169
13	Nephronophthisis (HP:0000090)	2.93875494
14	Abnormality of the renal cortex (HP:0011035)	2.87258586
15	Cystic liver disease (HP:0006706)	2.85602000
16	Type II lissencephaly (HP:0007260)	2.83963936
17	Protruding tongue (HP:0010808)	2.83606663
18	Medial flaring of the eyebrow (HP:0010747)	2.75286942
19	Abnormality of the renal medulla (HP:0100957)	2.73887868
20	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.72442732
21	Sclerocornea (HP:0000647)	2.67206692
22	Fair hair (HP:0002286)	2.57731570
23	Genetic anticipation (HP:0003743)	2.55599718
24	Chronic hepatic failure (HP:0100626)	2.53877676
25	Furrowed tongue (HP:0000221)	2.47955205
26	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36763960
27	Hyperalaninemia (HP:0003348)	2.36612425
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.36612425
29	Abnormality of alanine metabolism (HP:0010916)	2.36612425
30	Absent speech (HP:0001344)	2.33863197
31	Cerebellar dysplasia (HP:0007033)	2.32698377
32	Bony spicule pigmentary retinopathy (HP:0007737)	2.31003962
33	Febrile seizures (HP:0002373)	2.30265057
34	Focal seizures (HP:0007359)	2.29374957
35	Inability to walk (HP:0002540)	2.27964890
36	Abolished electroretinogram (ERG) (HP:0000550)	2.24904409
37	Gait imbalance (HP:0002141)	2.24553238
38	Concave nail (HP:0001598)	2.23012333
39	Broad-based gait (HP:0002136)	2.20301972
40	Hemiparesis (HP:0001269)	2.19926594
41	Congenital hepatic fibrosis (HP:0002612)	2.19823047
42	Congenital primary aphakia (HP:0007707)	2.19125679
43	Anencephaly (HP:0002323)	2.18888214
44	Tubular atrophy (HP:0000092)	2.15535310
45	Male pseudohermaphroditism (HP:0000037)	2.12413742
46	Bile duct proliferation (HP:0001408)	2.12101446
47	Abnormal biliary tract physiology (HP:0012439)	2.12101446
48	Absent/shortened dynein arms (HP:0200106)	2.11776010
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11776010
50	Congenital, generalized hypertrichosis (HP:0004540)	2.10755637
51	Generalized hypopigmentation of hair (HP:0011358)	2.10371800
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.06659253
53	Chromsome breakage (HP:0040012)	2.06291342
54	Genital tract atresia (HP:0001827)	2.05215046
55	Focal motor seizures (HP:0011153)	2.05209643
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03833965
57	Decreased central vision (HP:0007663)	2.03435282
58	Hypoplastic labia majora (HP:0000059)	2.02982035
59	Clumsiness (HP:0002312)	2.02837206
60	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.01609457
61	Hypoplasia of the fovea (HP:0007750)	2.01609457
62	Renal cortical cysts (HP:0000803)	2.01333083
63	Hypothermia (HP:0002045)	2.01203255
64	Preaxial hand polydactyly (HP:0001177)	2.00918536
65	Abnormality of the pons (HP:0007361)	2.00374415
66	Hypoplasia of the pons (HP:0012110)	1.98911603
67	Optic nerve hypoplasia (HP:0000609)	1.98390748
68	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.98286105
69	Polydipsia (HP:0001959)	1.97752209
70	Abnormal drinking behavior (HP:0030082)	1.97752209
71	Progressive inability to walk (HP:0002505)	1.97502860
72	Postaxial foot polydactyly (HP:0001830)	1.97269790
73	Nephrogenic diabetes insipidus (HP:0009806)	1.93802658
74	Dialeptic seizures (HP:0011146)	1.92105221
75	Birth length less than 3rd percentile (HP:0003561)	1.91626176
76	Vaginal atresia (HP:0000148)	1.90963174
77	Duplicated collecting system (HP:0000081)	1.90248182
78	Constricted visual fields (HP:0001133)	1.90049545
79	Abnormality of the renal collecting system (HP:0004742)	1.89884036
80	Abnormality of the labia majora (HP:0012881)	1.87866735
81	Astigmatism (HP:0000483)	1.86120868
82	Progressive macrocephaly (HP:0004481)	1.86091330
83	Abnormal ciliary motility (HP:0012262)	1.84839510
84	Blue irides (HP:0000635)	1.84047128
85	Widely spaced teeth (HP:0000687)	1.82739909
86	Ketoacidosis (HP:0001993)	1.82711532
87	Abnormality of the ileum (HP:0001549)	1.82353152
88	Absence seizures (HP:0002121)	1.81695466
89	Intestinal atresia (HP:0011100)	1.81149563
90	Poor coordination (HP:0002370)	1.80708293
91	Small hand (HP:0200055)	1.80288340
92	Acute necrotizing encephalopathy (HP:0006965)	1.79437604
93	Acute encephalopathy (HP:0006846)	1.78764646
94	Lissencephaly (HP:0001339)	1.77580222
95	Abnormality of the labia minora (HP:0012880)	1.76843288
96	Oligodactyly (hands) (HP:0001180)	1.76720628
97	Meckel diverticulum (HP:0002245)	1.76208686
98	Epileptic encephalopathy (HP:0200134)	1.75971653
99	Tubulointerstitial nephritis (HP:0001970)	1.75369056
100	Drooling (HP:0002307)	1.75083893

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.27563887
2	CASK	2.95002212
3	PNCK	2.92585205
4	ZAK	2.38540403
5	ACVR1B	2.27621313
6	ADRBK2	2.27376208
7	NUAK1	2.24058777
8	BMPR1B	2.16393519
9	PINK1	2.11190232
10	INSRR	2.09725535
11	TAOK3	2.01115328
12	MAPK13	1.98226272
13	WNK3	1.95367651
14	STK39	1.91185442
15	MKNK2	1.87470320
16	GRK1	1.83857771
17	WEE1	1.78200673
18	MAP4K2	1.69535720
19	WNK4	1.59162617
20	NTRK3	1.58353330
21	MAP3K4	1.41145519
22	NEK2	1.37581900
23	CCNB1	1.35223320
24	OXSR1	1.22733771
25	PLK2	1.22090881
26	NEK1	1.17862535
27	STK3	1.15757585
28	PAK3	1.15597269
29	MAPK15	1.14306001
30	STK38L	1.08196457
31	PDK2	1.07389390
32	PLK4	1.07339620
33	PTK2B	1.05488569
34	ADRBK1	1.01004830
35	BRSK2	1.00421024
36	TNIK	0.99757091
37	PRKCG	0.98757806
38	MAPKAPK3	0.97649728
39	MAPKAPK5	0.88764044
40	LATS1	0.84046965
41	PRKCE	0.79303780
42	MKNK1	0.77878921
43	MAP2K7	0.71423584
44	TGFBR1	0.71227783
45	TLK1	0.70679978
46	PHKG1	0.69863899
47	PHKG2	0.69863899
48	AKT3	0.69562385
49	MARK3	0.67605352
50	EIF2AK3	0.66572285
51	MARK1	0.66511328
52	PLK3	0.66181311
53	CAMK2A	0.64872887
54	PKN1	0.63320810
55	MUSK	0.60674881
56	CDK3	0.60069507
57	FGFR2	0.59367438
58	SIK2	0.58908614
59	TSSK6	0.58316997
60	NTRK2	0.58265546
61	DAPK2	0.58056920
62	CAMK1G	0.57813826
63	TEC	0.57640182
64	FER	0.56865058
65	PLK1	0.52806216
66	PIK3CG	0.52779536
67	VRK1	0.52269122
68	TRPM7	0.49306234
69	ATM	0.44947926
70	PRKAA2	0.44484743
71	NME1	0.44246662
72	CHEK2	0.43281024
73	CSNK1G2	0.43199738
74	CSNK1G1	0.43128932
75	TRIM28	0.40878533
76	SGK2	0.39220643
77	DMPK	0.37889130
78	OBSCN	0.37593639
79	PRKACA	0.37574017
80	CAMK1	0.37219027
81	PRKAA1	0.35745980
82	MST4	0.34819383
83	NLK	0.34270796
84	CSNK1A1	0.33992228
85	BCR	0.33879710
86	TIE1	0.33374699
87	PIK3CA	0.33162911
88	CAMKK2	0.32612485
89	CAMK2B	0.32210277
90	PRKACB	0.31866984
91	TTK	0.31581976
92	CSNK1A1L	0.31452952
93	RPS6KA5	0.30654475
94	CSNK1D	0.30011264
95	EIF2AK1	0.29413310
96	IRAK1	0.29265775
97	ATR	0.28504058
98	TNK2	0.27113500
99	CAMK2D	0.26577525
100	CSNK1G3	0.26524672

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.38476338
2	Nicotine addiction_Homo sapiens_hsa05033	2.93354196
3	Phototransduction_Homo sapiens_hsa04744	2.58848561
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.56624809
5	Homologous recombination_Homo sapiens_hsa03440	2.53821970
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.30411070
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.26488797
8	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.24315575
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.20379472
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.06007228
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01761553
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.01083805
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.94667417
14	Propanoate metabolism_Homo sapiens_hsa00640	1.93434214
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93105639
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.90967902
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86692223
18	Olfactory transduction_Homo sapiens_hsa04740	1.82987705
19	ABC transporters_Homo sapiens_hsa02010	1.80437956
20	Taste transduction_Homo sapiens_hsa04742	1.76274548
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.74318723
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65348093
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.60497438
24	Morphine addiction_Homo sapiens_hsa05032	1.45341383
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.42961332
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.41691009
27	Circadian entrainment_Homo sapiens_hsa04713	1.38794104
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.34396673
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32642188
30	GABAergic synapse_Homo sapiens_hsa04727	1.27308325
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25866304
32	Retinol metabolism_Homo sapiens_hsa00830	1.19200050
33	Insulin secretion_Homo sapiens_hsa04911	1.19187959
34	Basal transcription factors_Homo sapiens_hsa03022	1.18596690
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18350640
36	Protein export_Homo sapiens_hsa03060	1.17650916
37	One carbon pool by folate_Homo sapiens_hsa00670	1.16301934
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.14511124
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.13005369
40	Serotonergic synapse_Homo sapiens_hsa04726	1.12653404
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.07719131
42	Salivary secretion_Homo sapiens_hsa04970	1.06973757
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.04625281
44	Calcium signaling pathway_Homo sapiens_hsa04020	1.03374367
45	Oxidative phosphorylation_Homo sapiens_hsa00190	1.02448161
46	Peroxisome_Homo sapiens_hsa04146	1.02280010
47	Caffeine metabolism_Homo sapiens_hsa00232	0.97859567
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.96789911
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94325001
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94057536
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.84734569
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.84635610
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83516767
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.82221612
55	Fatty acid degradation_Homo sapiens_hsa00071	0.79846028
56	Parkinsons disease_Homo sapiens_hsa05012	0.78843236
57	Amphetamine addiction_Homo sapiens_hsa05031	0.77044256
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77011395
59	Cocaine addiction_Homo sapiens_hsa05030	0.76591075
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76438000
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75480844
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74933200
63	Purine metabolism_Homo sapiens_hsa00230	0.72225292
64	Circadian rhythm_Homo sapiens_hsa04710	0.71417800
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.70531506
66	RNA degradation_Homo sapiens_hsa03018	0.69714562
67	RNA polymerase_Homo sapiens_hsa03020	0.69571874
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69419567
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67209013
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67200382
71	Long-term depression_Homo sapiens_hsa04730	0.66315712
72	Histidine metabolism_Homo sapiens_hsa00340	0.62652822
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62418886
74	Huntingtons disease_Homo sapiens_hsa05016	0.60792573
75	Lysine degradation_Homo sapiens_hsa00310	0.60361190
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59289261
77	Regulation of autophagy_Homo sapiens_hsa04140	0.57576857
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56840405
79	Mismatch repair_Homo sapiens_hsa03430	0.56384848
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.55416878
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.55182640
82	Metabolic pathways_Homo sapiens_hsa01100	0.54218436
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51978208
84	Mineral absorption_Homo sapiens_hsa04978	0.51335170
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49950326
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.48886671
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48681942
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47064165
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47052686
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.46107237
91	Cholinergic synapse_Homo sapiens_hsa04725	0.46036836
92	Alzheimers disease_Homo sapiens_hsa05010	0.44853568
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44681929
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.44247165
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.43921441
96	Renin secretion_Homo sapiens_hsa04924	0.41158906
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40468326
98	Oocyte meiosis_Homo sapiens_hsa04114	0.38892256
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.38743764
100	Gastric acid secretion_Homo sapiens_hsa04971	0.38551256

ANKRD20A3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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