ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.88291078
2	righting reflex (GO:0060013)	4.71786226
3	cellular ketone body metabolic process (GO:0046950)	4.58612996
4	auditory receptor cell stereocilium organization (GO:0060088)	4.29718380
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.26940672
6	ketone body metabolic process (GO:1902224)	4.21930803
7	detection of light stimulus involved in visual perception (GO:0050908)	4.01593455
8	detection of light stimulus involved in sensory perception (GO:0050962)	4.01593455
9	tryptophan catabolic process (GO:0006569)	4.00284334
10	indole-containing compound catabolic process (GO:0042436)	4.00284334
11	indolalkylamine catabolic process (GO:0046218)	4.00284334
12	reflex (GO:0060004)	3.99636171
13	startle response (GO:0001964)	3.86289752
14	indolalkylamine metabolic process (GO:0006586)	3.76360701
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.71447310
16	synapsis (GO:0007129)	3.68804440
17	photoreceptor cell maintenance (GO:0045494)	3.68291102
18	multicellular organism reproduction (GO:0032504)	3.68290787
19	sperm motility (GO:0030317)	3.57355704
20	regulation of meiosis I (GO:0060631)	3.57101459
21	epithelial cilium movement (GO:0003351)	3.56037285
22	male meiosis (GO:0007140)	3.53831364
23	establishment of protein localization to Golgi (GO:0072600)	3.53054757
24	monoubiquitinated protein deubiquitination (GO:0035520)	3.45812373
25	regulation of hippo signaling (GO:0035330)	3.35833547
26	piRNA metabolic process (GO:0034587)	3.29257747
27	behavioral response to nicotine (GO:0035095)	3.25107540
28	tryptophan metabolic process (GO:0006568)	3.22423195
29	DNA methylation involved in gamete generation (GO:0043046)	3.21397550
30	protein K11-linked deubiquitination (GO:0035871)	3.21363133
31	acrosome reaction (GO:0007340)	3.21322276
32	L-fucose catabolic process (GO:0042355)	3.16592113
33	fucose catabolic process (GO:0019317)	3.16592113
34	L-fucose metabolic process (GO:0042354)	3.16592113
35	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.15765398
36	primary amino compound metabolic process (GO:1901160)	3.15221321
37	TOR signaling (GO:0031929)	3.13476659
38	serotonin metabolic process (GO:0042428)	3.12577479
39	negative regulation of sodium ion transport (GO:0010766)	3.11427654
40	cellular response to sterol (GO:0036315)	3.11340628
41	DNA double-strand break processing (GO:0000729)	3.10465551
42	negative regulation of systemic arterial blood pressure (GO:0003085)	3.10030069
43	regulation of acrosome reaction (GO:0060046)	3.08355375
44	indole-containing compound metabolic process (GO:0042430)	3.07833553
45	neuronal action potential (GO:0019228)	3.07776551
46	inner ear receptor stereocilium organization (GO:0060122)	3.03469469
47	cilium movement (GO:0003341)	3.00918320
48	nonmotile primary cilium assembly (GO:0035058)	2.98393623
49	axoneme assembly (GO:0035082)	2.96660584
50	replication fork processing (GO:0031297)	2.94563158
51	kynurenine metabolic process (GO:0070189)	2.94373354
52	neuronal action potential propagation (GO:0019227)	2.94217849
53	regulation of establishment of cell polarity (GO:2000114)	2.92312034
54	response to pheromone (GO:0019236)	2.92227352
55	aromatic amino acid family catabolic process (GO:0009074)	2.87646387
56	high-density lipoprotein particle remodeling (GO:0034375)	2.85673655
57	interkinetic nuclear migration (GO:0022027)	2.83582428
58	motile cilium assembly (GO:0044458)	2.82499383
59	gamma-aminobutyric acid transport (GO:0015812)	2.81431287
60	neural tube formation (GO:0001841)	2.81085565
61	fusion of sperm to egg plasma membrane (GO:0007342)	2.80769920
62	protein targeting to Golgi (GO:0000042)	2.80175555
63	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.79052620
64	double-strand break repair via homologous recombination (GO:0000724)	2.76431300
65	organic cation transport (GO:0015695)	2.75843982
66	recombinational repair (GO:0000725)	2.74807485
67	spermatid development (GO:0007286)	2.74629662
68	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.73537521
69	regulation of translation, ncRNA-mediated (GO:0045974)	2.73537521
70	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.73537521
71	regulation of glucokinase activity (GO:0033131)	2.72673224
72	regulation of hexokinase activity (GO:1903299)	2.72673224
73	centriole replication (GO:0007099)	2.70998115
74	oxidative demethylation (GO:0070989)	2.70819466
75	positive regulation of glycolytic process (GO:0045821)	2.67337846
76	cilium organization (GO:0044782)	2.67056239
77	signal peptide processing (GO:0006465)	2.66327121
78	regulation of cilium movement (GO:0003352)	2.66146962
79	resolution of meiotic recombination intermediates (GO:0000712)	2.65282925
80	cilium assembly (GO:0042384)	2.63842586
81	activation of protein kinase B activity (GO:0032148)	2.61691153
82	membrane depolarization during action potential (GO:0086010)	2.61293076
83	reverse cholesterol transport (GO:0043691)	2.61187255
84	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.61006931
85	positive regulation of meiotic cell cycle (GO:0051446)	2.56779156
86	behavioral response to ethanol (GO:0048149)	2.56638454
87	positive regulation of meiosis (GO:0045836)	2.55823765
88	adaptation of signaling pathway (GO:0023058)	2.55451271
89	sulfation (GO:0051923)	2.54602598
90	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.53647154
91	chromosome organization involved in meiosis (GO:0070192)	2.52098942
92	aromatic amino acid family metabolic process (GO:0009072)	2.50490772
93	meiotic chromosome segregation (GO:0045132)	2.49007233
94	protein localization to Golgi apparatus (GO:0034067)	2.48792772
95	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.48434046
96	cellular biogenic amine catabolic process (GO:0042402)	2.46330750
97	amine catabolic process (GO:0009310)	2.46330750
98	benzene-containing compound metabolic process (GO:0042537)	2.44729054
99	positive regulation of catecholamine secretion (GO:0033605)	2.43510727
100	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.43478127

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.37318795
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.40496058
3	VDR_22108803_ChIP-Seq_LS180_Human	3.23472942
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04592820
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.82126762
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.60511021
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.60345716
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54117857
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.53934228
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.50427252
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.50286100
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.41798711
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.27752482
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.26958176
15	FUS_26573619_Chip-Seq_HEK293_Human	2.16913132
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16905069
17	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.12028495
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.07304060
19	P300_19829295_ChIP-Seq_ESCs_Human	2.03325056
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.97733234
21	EWS_26573619_Chip-Seq_HEK293_Human	1.94920907
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93313728
23	STAT3_23295773_ChIP-Seq_U87_Human	1.91921604
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.88850820
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87185951
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.84157656
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.82352525
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.81008138
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.80544611
30	TCF4_23295773_ChIP-Seq_U87_Human	1.77205405
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.73079988
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.68944324
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68944324
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63407167
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63012895
36	AR_25329375_ChIP-Seq_VCAP_Human	1.62694387
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.58822497
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.56125522
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53549579
40	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.53520029
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50529471
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50529471
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49397880
44	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.48479978
45	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.45592265
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45042232
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43307848
48	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.41488599
49	AHR_22903824_ChIP-Seq_MCF-7_Human	1.41385615
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.40368992
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40333038
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.38779319
53	TP53_16413492_ChIP-PET_HCT116_Human	1.36718889
54	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28446632
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28374958
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27790659
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27440150
58	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24579576
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23707441
60	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.23672489
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22262840
62	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.21850373
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20386804
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19553013
65	RXR_22108803_ChIP-Seq_LS180_Human	1.19200761
66	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.19171174
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.17891737
68	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.17836301
69	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17835303
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17393605
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17050911
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17050911
73	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16160745
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14716768
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12996201
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12832884
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12753171
78	TP53_22573176_ChIP-Seq_HFKS_Human	1.12117886
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11989374
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09166914
81	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.09145930
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08793397
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08767346
84	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.07426351
85	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07057224
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.04058471
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01853902
88	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.01691926
89	KDM2B_26808549_Chip-Seq_REH_Human	1.01559371
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98803277
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98416644
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98197930
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97897091
94	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97699450
95	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97511692
96	REST_21632747_ChIP-Seq_MESCs_Mouse	0.96193094
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95585135
98	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.94577246
99	TBL1_22424771_ChIP-Seq_293T_Human	0.94392011
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94128436

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.44993632
2	MP0005410_abnormal_fertilization	3.29569634
3	MP0002736_abnormal_nociception_after	3.02452210
4	MP0001968_abnormal_touch/_nociception	2.84975880
5	MP0003195_calcinosis	2.75998148
6	MP0005551_abnormal_eye_electrophysiolog	2.72911010
7	MP0000569_abnormal_digit_pigmentation	2.72666022
8	MP0008877_abnormal_DNA_methylation	2.69341507
9	MP0003136_yellow_coat_color	2.46550782
10	MP0009046_muscle_twitch	2.39810871
11	MP0005646_abnormal_pituitary_gland	2.33146557
12	MP0003646_muscle_fatigue	2.32640318
13	MP0004043_abnormal_pH_regulation	2.02631435
14	MP0002102_abnormal_ear_morphology	1.89104123
15	MP0008872_abnormal_physiological_respon	1.83760372
16	MP0009780_abnormal_chondrocyte_physiolo	1.80268587
17	MP0001984_abnormal_olfaction	1.78634223
18	MP0001501_abnormal_sleep_pattern	1.76279171
19	MP0001486_abnormal_startle_reflex	1.75413408
20	MP0005670_abnormal_white_adipose	1.75222676
21	MP0010329_abnormal_lipoprotein_level	1.69598745
22	MP0000427_abnormal_hair_cycle	1.67123234
23	MP0003698_abnormal_male_reproductive	1.66242302
24	MP0001929_abnormal_gametogenesis	1.65023767
25	MP0002160_abnormal_reproductive_system	1.61262162
26	MP0003045_fibrosis	1.60726491
27	MP0005174_abnormal_tail_pigmentation	1.59666766
28	MP0001986_abnormal_taste_sensitivity	1.49472010
29	MP0005647_abnormal_sex_gland	1.45815682
30	MP0009745_abnormal_behavioral_response	1.45441717
31	MP0000631_abnormal_neuroendocrine_gland	1.42559815
32	MP0005645_abnormal_hypothalamus_physiol	1.41711799
33	MP0008875_abnormal_xenobiotic_pharmacok	1.40510561
34	MP0005253_abnormal_eye_physiology	1.36135649
35	MP0002272_abnormal_nervous_system	1.34409821
36	MP0002876_abnormal_thyroid_physiology	1.33869382
37	MP0000372_irregular_coat_pigmentation	1.33668766
38	MP0004742_abnormal_vestibular_system	1.31786725
39	MP0002837_dystrophic_cardiac_calcinosis	1.30755561
40	MP0009697_abnormal_copulation	1.30146370
41	MP0001485_abnormal_pinna_reflex	1.29589046
42	MP0002210_abnormal_sex_determination	1.27303118
43	MP0004147_increased_porphyrin_level	1.26668056
44	MP0003787_abnormal_imprinting	1.23850839
45	MP0005389_reproductive_system_phenotype	1.22354760
46	MP0002938_white_spotting	1.22093388
47	MP0000383_abnormal_hair_follicle	1.20530598
48	MP0004381_abnormal_hair_follicle	1.19692883
49	MP0008995_early_reproductive_senescence	1.18459317
50	MP0002168_other_aberrant_phenotype	1.17943503
51	MP0010386_abnormal_urinary_bladder	1.17079305
52	MP0002067_abnormal_sensory_capabilities	1.16519405
53	MP0002638_abnormal_pupillary_reflex	1.14679443
54	MP0001664_abnormal_digestion	1.13668458
55	MP0005085_abnormal_gallbladder_physiolo	1.10370414
56	MP0005408_hypopigmentation	1.09458393
57	MP0002064_seizures	1.08743565
58	MP0000653_abnormal_sex_gland	1.06848561
59	MP0003252_abnormal_bile_duct	1.04598282
60	MP0002138_abnormal_hepatobiliary_system	1.04170991
61	MP0001666_abnormal_nutrient_absorption	1.03850687
62	MP0001145_abnormal_male_reproductive	1.01375591
63	MP0003718_maternal_effect	1.00366328
64	MP0005379_endocrine/exocrine_gland_phen	0.95688424
65	MP0005395_other_phenotype	0.93818652
66	MP0008961_abnormal_basal_metabolism	0.93131448
67	MP0002557_abnormal_social/conspecific_i	0.92625715
68	MP0000639_abnormal_adrenal_gland	0.92549070
69	MP0004885_abnormal_endolymph	0.92005395
70	MP0001919_abnormal_reproductive_system	0.91687267
71	MP0003635_abnormal_synaptic_transmissio	0.91634529
72	MP0002928_abnormal_bile_duct	0.91508585
73	MP0004145_abnormal_muscle_electrophysio	0.90334585
74	MP0003633_abnormal_nervous_system	0.89555012
75	MP0003950_abnormal_plasma_membrane	0.88424617
76	MP0005365_abnormal_bile_salt	0.87090478
77	MP0001270_distended_abdomen	0.86694695
78	MP0002572_abnormal_emotion/affect_behav	0.86566253
79	MP0003183_abnormal_peptide_metabolism	0.85542553
80	MP0002229_neurodegeneration	0.84465634
81	MP0001963_abnormal_hearing_physiology	0.81070482
82	MP0005636_abnormal_mineral_homeostasis	0.80918271
83	MP0004215_abnormal_myocardial_fiber	0.80137114
84	MP0003631_nervous_system_phenotype	0.78610913
85	MP0004924_abnormal_behavior	0.77258528
86	MP0005386_behavior/neurological_phenoty	0.77258528
87	MP0005360_urolithiasis	0.76370195
88	MP0003936_abnormal_reproductive_system	0.75366122
89	MP0006292_abnormal_olfactory_placode	0.74631083
90	MP0005266_abnormal_metabolism	0.74516343
91	MP0002132_abnormal_respiratory_system	0.73441947
92	MP0000015_abnormal_ear_pigmentation	0.73430438
93	MP0002095_abnormal_skin_pigmentation	0.72787555
94	MP0001764_abnormal_homeostasis	0.72337349
95	MP0002161_abnormal_fertility/fecundity	0.72222119
96	MP0006276_abnormal_autonomic_nervous	0.71965417
97	MP0003315_abnormal_perineum_morphology	0.71847500
98	MP0000538_abnormal_urinary_bladder	0.71544946
99	MP0000026_abnormal_inner_ear	0.70936651
100	MP0010678_abnormal_skin_adnexa	0.70852877

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.43825114
2	Congenital sensorineural hearing impairment (HP:0008527)	4.29799322
3	Pancreatic cysts (HP:0001737)	4.07833670
4	Gaze-evoked nystagmus (HP:0000640)	3.59882964
5	Pancreatic fibrosis (HP:0100732)	3.57374210
6	Protruding tongue (HP:0010808)	3.55859407
7	Chronic hepatic failure (HP:0100626)	3.47934500
8	True hermaphroditism (HP:0010459)	3.39871028
9	Abnormality of the renal cortex (HP:0011035)	3.36515186
10	Cerebellar dysplasia (HP:0007033)	3.22509108
11	Attenuation of retinal blood vessels (HP:0007843)	3.18475012
12	Febrile seizures (HP:0002373)	3.14419476
13	Abnormality of midbrain morphology (HP:0002418)	3.02948996
14	Molar tooth sign on MRI (HP:0002419)	3.02948996
15	Type II lissencephaly (HP:0007260)	3.00028703
16	Cystic liver disease (HP:0006706)	2.98764551
17	Absent speech (HP:0001344)	2.78034085
18	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.74580995
19	Renal cortical cysts (HP:0000803)	2.71286723
20	Intestinal atresia (HP:0011100)	2.69460985
21	Facial hemangioma (HP:0000329)	2.66388006
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.64301914
23	Absent/shortened dynein arms (HP:0200106)	2.64301914
24	Congenital stationary night blindness (HP:0007642)	2.63463096
25	Large for gestational age (HP:0001520)	2.62595382
26	Medial flaring of the eyebrow (HP:0010747)	2.55793559
27	Male pseudohermaphroditism (HP:0000037)	2.52576352
28	Abnormal drinking behavior (HP:0030082)	2.52489082
29	Polydipsia (HP:0001959)	2.52489082
30	Abnormality of alanine metabolism (HP:0010916)	2.52326324
31	Hyperalaninemia (HP:0003348)	2.52326324
32	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52326324
33	Hypothermia (HP:0002045)	2.51337540
34	Pigmentary retinal degeneration (HP:0001146)	2.44726903
35	Nephronophthisis (HP:0000090)	2.44214231
36	Fair hair (HP:0002286)	2.41235059
37	Atonic seizures (HP:0010819)	2.40911759
38	Abnormality of the renal medulla (HP:0100957)	2.40544299
39	Bony spicule pigmentary retinopathy (HP:0007737)	2.40154621
40	Chromsome breakage (HP:0040012)	2.39278511
41	Tubular atrophy (HP:0000092)	2.38701051
42	Clumsiness (HP:0002312)	2.35645280
43	Abnormal biliary tract physiology (HP:0012439)	2.34607568
44	Bile duct proliferation (HP:0001408)	2.34607568
45	Abnormality of the ileum (HP:0001549)	2.32465524
46	Volvulus (HP:0002580)	2.27638805
47	Hypoplastic labia majora (HP:0000059)	2.26045190
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.26016026
49	Enlarged kidneys (HP:0000105)	2.25840673
50	Abolished electroretinogram (ERG) (HP:0000550)	2.25713616
51	Furrowed tongue (HP:0000221)	2.21744727
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.19414662
53	Spontaneous abortion (HP:0005268)	2.17093391
54	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.15470180
55	Meckel diverticulum (HP:0002245)	2.15077673
56	Focal seizures (HP:0007359)	2.13335888
57	Abnormal ciliary motility (HP:0012262)	2.12631310
58	Broad-based gait (HP:0002136)	2.09835775
59	Generalized hypopigmentation of hair (HP:0011358)	2.09078114
60	Inability to walk (HP:0002540)	2.08804838
61	Supernumerary spleens (HP:0009799)	2.07450848
62	Widely spaced teeth (HP:0000687)	2.07342981
63	Hypobetalipoproteinemia (HP:0003563)	2.07144100
64	Abnormality of the labia majora (HP:0012881)	2.06794249
65	Acanthocytosis (HP:0001927)	2.05730114
66	Clubbing of toes (HP:0100760)	2.05353735
67	Hemiparesis (HP:0001269)	2.03005676
68	Decreased central vision (HP:0007663)	2.02766011
69	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.01102637
70	Congenital primary aphakia (HP:0007707)	2.00803509
71	Congenital hepatic fibrosis (HP:0002612)	1.98649595
72	Tubulointerstitial nephritis (HP:0001970)	1.98220343
73	Abnormality of chromosome stability (HP:0003220)	1.97378681
74	Gait imbalance (HP:0002141)	1.97165401
75	Astigmatism (HP:0000483)	1.96979377
76	Progressive cerebellar ataxia (HP:0002073)	1.96591939
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94797876
78	Poor coordination (HP:0002370)	1.94684269
79	Focal motor seizures (HP:0011153)	1.93885215
80	Epidermoid cyst (HP:0200040)	1.93177046
81	Genetic anticipation (HP:0003743)	1.93053661
82	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.89593404
83	Genital tract atresia (HP:0001827)	1.88892807
84	Concave nail (HP:0001598)	1.87678930
85	Dyskinesia (HP:0100660)	1.86831082
86	Absence seizures (HP:0002121)	1.86504400
87	Sex reversal (HP:0012245)	1.86330484
88	Abnormal sex determination (HP:0012244)	1.86330484
89	Constricted visual fields (HP:0001133)	1.84325028
90	Sloping forehead (HP:0000340)	1.83299404
91	Capillary hemangiomas (HP:0005306)	1.80264622
92	Pancreatic islet-cell hyperplasia (HP:0004510)	1.80152428
93	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78743011
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.78743011
95	Vaginal atresia (HP:0000148)	1.76870633
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.74423317
97	Anencephaly (HP:0002323)	1.73463857
98	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.71741396
99	Polyuria (HP:0000103)	1.71684625
100	Gastrointestinal atresia (HP:0002589)	1.71201649

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.60271409
2	PINK1	4.66089407
3	BMPR1B	2.59740142
4	ACVR1B	2.52449794
5	NUAK1	2.37507348
6	MARK3	2.12740895
7	ADRBK2	1.92649186
8	MAPK13	1.83543927
9	BRSK2	1.77638269
10	INSRR	1.75377573
11	NTRK3	1.72438619
12	PLK4	1.65925386
13	ZAK	1.64636204
14	WNK4	1.60512233
15	FGFR2	1.59998716
16	CASK	1.59862867
17	WEE1	1.56162665
18	MKNK2	1.55421824
19	LATS1	1.45434177
20	PTK2B	1.41550158
21	GRK1	1.41098537
22	NEK2	1.40600003
23	TLK1	1.31059944
24	MAP4K2	1.28549963
25	STK39	1.27723723
26	TAOK3	1.20101762
27	AKT3	1.18516803
28	WNK3	1.18107708
29	PAK3	1.15533316
30	MAP3K4	1.12159626
31	PNCK	1.11653553
32	CDK3	1.08761937
33	PIK3CA	1.06595979
34	SGK2	1.01919554
35	PIK3CG	1.00428802
36	OBSCN	0.99290463
37	PLK2	0.97153282
38	STK38L	0.94352329
39	CCNB1	0.93551834
40	PRKCQ	0.88298418
41	MAP2K7	0.84700484
42	SGK223	0.79961551
43	SGK494	0.79961551
44	PKN1	0.79176783
45	RPS6KB2	0.77025108
46	PRKCE	0.72914288
47	ADRBK1	0.71988232
48	TNIK	0.71496551
49	DMPK	0.71459345
50	STK3	0.70814164
51	MAP2K6	0.67826467
52	TRPM7	0.67429839
53	STK38	0.65347746
54	SIK2	0.62976908
55	CSNK1D	0.62428585
56	MYLK	0.60846650
57	CAMK2A	0.59458722
58	PRKCG	0.58830324
59	MAPKAPK3	0.58513624
60	RPS6KA5	0.57261694
61	CAMK2D	0.56630347
62	ATM	0.55944730
63	OXSR1	0.55919299
64	RPS6KB1	0.54926069
65	MAP3K2	0.53265622
66	MST4	0.52839960
67	TNK2	0.52679222
68	PDK2	0.52548377
69	ROCK1	0.50494626
70	MELK	0.50414201
71	NLK	0.50412769
72	SGK3	0.50040747
73	MAP3K7	0.49798172
74	CAMK2B	0.49609864
75	TGFBR1	0.49578531
76	FLT3	0.48593094
77	PRKAA2	0.47386156
78	PBK	0.47216604
79	FGFR3	0.46039784
80	TEC	0.44313782
81	SGK1	0.42765547
82	MAPK11	0.41109051
83	PHKG1	0.40705471
84	PHKG2	0.40705471
85	PRKG1	0.40424914
86	WNK1	0.40122206
87	DAPK2	0.39639854
88	CSNK1G1	0.38273236
89	PRKAA1	0.36724132
90	VRK1	0.35295638
91	CSNK1A1L	0.34737453
92	CAMK1G	0.34633938
93	CSNK1A1	0.33502692
94	CAMK1	0.32744028
95	MAP2K1	0.32268085
96	EPHA4	0.30241742
97	PRKACA	0.30108454
98	CAMK4	0.29706017
99	CAMKK2	0.29369400
100	PRKCB	0.29102746

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.27269814
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.15765586
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.85315395
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.33860782
5	ABC transporters_Homo sapiens_hsa02010	2.23848629
6	Phototransduction_Homo sapiens_hsa04744	2.16235723
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.15643635
8	Olfactory transduction_Homo sapiens_hsa04740	2.07056806
9	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.04846639
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.03354443
11	Propanoate metabolism_Homo sapiens_hsa00640	1.96704295
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.96502088
13	Nicotine addiction_Homo sapiens_hsa05033	1.92240976
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.86279474
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.82337909
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.81584501
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81369890
18	Fat digestion and absorption_Homo sapiens_hsa04975	1.80622345
19	Homologous recombination_Homo sapiens_hsa03440	1.79874442
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.75289097
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.71112506
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.69528496
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.68584171
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.67030346
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.52076682
26	Taste transduction_Homo sapiens_hsa04742	1.46566362
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.44258026
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.41052195
29	Fatty acid degradation_Homo sapiens_hsa00071	1.36397439
30	Glycerolipid metabolism_Homo sapiens_hsa00561	1.30031260
31	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.24075924
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.20038855
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.18430791
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18252774
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17696001
36	Salivary secretion_Homo sapiens_hsa04970	1.15537348
37	Calcium signaling pathway_Homo sapiens_hsa04020	1.13972878
38	Retinol metabolism_Homo sapiens_hsa00830	1.10762882
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.09150925
40	Circadian entrainment_Homo sapiens_hsa04713	1.08711688
41	Peroxisome_Homo sapiens_hsa04146	1.04929674
42	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.04474180
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04303623
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.02964512
45	Lysine degradation_Homo sapiens_hsa00310	1.02231548
46	Caffeine metabolism_Homo sapiens_hsa00232	1.01511215
47	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.01383791
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.96615498
49	Circadian rhythm_Homo sapiens_hsa04710	0.96453168
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.92228877
51	One carbon pool by folate_Homo sapiens_hsa00670	0.91150929
52	Histidine metabolism_Homo sapiens_hsa00340	0.91015601
53	Morphine addiction_Homo sapiens_hsa05032	0.90388391
54	Renin secretion_Homo sapiens_hsa04924	0.88380715
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88137105
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83662823
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83615755
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.83585181
59	Insulin secretion_Homo sapiens_hsa04911	0.82270949
60	Regulation of autophagy_Homo sapiens_hsa04140	0.82001437
61	Complement and coagulation cascades_Homo sapiens_hsa04610	0.80254160
62	Arginine biosynthesis_Homo sapiens_hsa00220	0.75545586
63	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71585435
64	Serotonergic synapse_Homo sapiens_hsa04726	0.70542393
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68591634
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.68408913
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67284484
68	RNA degradation_Homo sapiens_hsa03018	0.66948258
69	Basal transcription factors_Homo sapiens_hsa03022	0.66661620
70	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.66040679
71	GABAergic synapse_Homo sapiens_hsa04727	0.58473668
72	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.57473024
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54362911
74	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53684574
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53487454
76	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.52624209
77	Gastric acid secretion_Homo sapiens_hsa04971	0.50629982
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50588424
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50055783
80	Purine metabolism_Homo sapiens_hsa00230	0.49511819
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.49425096
82	Pancreatic secretion_Homo sapiens_hsa04972	0.48945422
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.47029149
84	Glutathione metabolism_Homo sapiens_hsa00480	0.45608648
85	Amphetamine addiction_Homo sapiens_hsa05031	0.44123877
86	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42970029
87	Metabolic pathways_Homo sapiens_hsa01100	0.39883231
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39633822
89	Mineral absorption_Homo sapiens_hsa04978	0.39499406
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.37638328
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.35623705
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34011527
93	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.33699629
94	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.33593054
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32850132
96	Graft-versus-host disease_Homo sapiens_hsa05332	0.32477076
97	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32453985
98	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.32231401
99	Gap junction_Homo sapiens_hsa04540	0.31829725
100	Glucagon signaling pathway_Homo sapiens_hsa04922	0.28369567

ANKRD20A5P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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