ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	5.73833030
2	neuronal action potential propagation (GO:0019227)	5.05566750
3	axon ensheathment in central nervous system (GO:0032291)	4.57112840
4	central nervous system myelination (GO:0022010)	4.57112840
5	hindbrain development (GO:0030902)	4.50424203
6	presynaptic membrane assembly (GO:0097105)	4.38122458
7	regulation of timing of cell differentiation (GO:0048505)	4.30603588
8	neuronal stem cell maintenance (GO:0097150)	4.18962891
9	otic vesicle formation (GO:0030916)	4.00902188
10	neuron fate determination (GO:0048664)	3.87389792
11	cerebral cortex radially oriented cell migration (GO:0021799)	3.87267769
12	astrocyte development (GO:0014002)	3.77597662
13	startle response (GO:0001964)	3.75662405
14	regulation of development, heterochronic (GO:0040034)	3.74875950
15	presynaptic membrane organization (GO:0097090)	3.71491588
16	cellular response to leptin stimulus (GO:0044320)	3.70018737
17	postsynaptic membrane organization (GO:0001941)	3.69541737
18	negative regulation of astrocyte differentiation (GO:0048712)	3.65887520
19	nonmotile primary cilium assembly (GO:0035058)	3.65508781
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63287794
21	astrocyte differentiation (GO:0048708)	3.60073072
22	forebrain neuron differentiation (GO:0021879)	3.60057038
23	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.55909694
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.54854703
25	nephron tubule morphogenesis (GO:0072078)	3.54207076
26	nephron epithelium morphogenesis (GO:0072088)	3.54207076
27	neuron cell-cell adhesion (GO:0007158)	3.51047258
28	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.41695531
29	behavioral response to nicotine (GO:0035095)	3.36514003
30	telencephalon development (GO:0021537)	3.31786297
31	negative regulation of glial cell differentiation (GO:0045686)	3.30989296
32	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.29028236
33	proline transport (GO:0015824)	3.26647746
34	response to leptin (GO:0044321)	3.24149192
35	cochlea development (GO:0090102)	3.22275724
36	detection of light stimulus involved in sensory perception (GO:0050962)	3.20694676
37	detection of light stimulus involved in visual perception (GO:0050908)	3.20694676
38	regulation of cilium movement (GO:0003352)	3.17039723
39	eye photoreceptor cell differentiation (GO:0001754)	3.16470540
40	photoreceptor cell differentiation (GO:0046530)	3.16470540
41	protein localization to synapse (GO:0035418)	3.14742727
42	epithelial cilium movement (GO:0003351)	3.13801057
43	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.13675008
44	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.09046005
45	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.08869668
46	neuronal action potential (GO:0019228)	3.08842544
47	regulation of response to food (GO:0032095)	3.05915467
48	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.02095966
49	cornea development in camera-type eye (GO:0061303)	3.01205627
50	synaptic transmission, glutamatergic (GO:0035249)	2.97658408
51	glutamate receptor signaling pathway (GO:0007215)	2.94903693
52	regulation of respiratory system process (GO:0044065)	2.93139097
53	regulation of voltage-gated calcium channel activity (GO:1901385)	2.89957269
54	radial glial cell differentiation (GO:0060019)	2.89836206
55	detection of calcium ion (GO:0005513)	2.89237466
56	transmission of nerve impulse (GO:0019226)	2.86761257
57	nucleobase catabolic process (GO:0046113)	2.85665803
58	cilium morphogenesis (GO:0060271)	2.82907132
59	regulation of microtubule-based movement (GO:0060632)	2.79200201
60	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.78213421
61	renal tubule morphogenesis (GO:0061333)	2.77792090
62	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.77007060
63	cell proliferation in forebrain (GO:0021846)	2.73832546
64	positive regulation of synapse assembly (GO:0051965)	2.71998631
65	prepulse inhibition (GO:0060134)	2.71599317
66	pattern specification involved in kidney development (GO:0061004)	2.71010649
67	somite development (GO:0061053)	2.70623006
68	C4-dicarboxylate transport (GO:0015740)	2.70618524
69	cellular response to nitric oxide (GO:0071732)	2.69179534
70	cilium movement (GO:0003341)	2.68761158
71	adult walking behavior (GO:0007628)	2.68192269
72	auditory behavior (GO:0031223)	2.67429211
73	positive regulation of Notch signaling pathway (GO:0045747)	2.64852256
74	behavioral defense response (GO:0002209)	2.64356971
75	behavioral fear response (GO:0001662)	2.64356971
76	spinal cord association neuron differentiation (GO:0021527)	2.64010970
77	synapse assembly (GO:0007416)	2.63990233
78	retinal ganglion cell axon guidance (GO:0031290)	2.63688777
79	atrial cardiac muscle cell action potential (GO:0086014)	2.63166923
80	glutamate secretion (GO:0014047)	2.61767593
81	photoreceptor cell development (GO:0042461)	2.60772626
82	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.60750314
83	smoothened signaling pathway (GO:0007224)	2.60633069
84	central nervous system projection neuron axonogenesis (GO:0021952)	2.60519402
85	Sertoli cell development (GO:0060009)	2.59917568
86	membrane depolarization during action potential (GO:0086010)	2.59292174
87	response to auditory stimulus (GO:0010996)	2.59205661
88	limb bud formation (GO:0060174)	2.58952773
89	regulation of protein glycosylation (GO:0060049)	2.56702803
90	negative regulation of response to food (GO:0032096)	2.54439021
91	negative regulation of appetite (GO:0032099)	2.54439021
92	dermatan sulfate biosynthetic process (GO:0030208)	2.54287119
93	positive regulation of dendritic spine development (GO:0060999)	2.53377934
94	negative regulation of axon extension (GO:0030517)	2.53370428
95	negative regulation of gliogenesis (GO:0014014)	2.53104707
96	dendritic spine morphogenesis (GO:0060997)	2.51834978
97	regulation of oligodendrocyte differentiation (GO:0048713)	2.50861795
98	fear response (GO:0042596)	2.50450676
99	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.50018202
100	neuron-neuron synaptic transmission (GO:0007270)	2.49712962

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.01970428
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.40295774
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.02030049
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.90222088
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70754443
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61811309
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.41845339
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.41623879
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.38431910
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.36881223
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29093070
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.21465884
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19670854
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.18312391
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.17673051
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.17663145
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.08719535
18	FUS_26573619_Chip-Seq_HEK293_Human	2.08648280
19	VDR_22108803_ChIP-Seq_LS180_Human	2.05030413
20	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.04748622
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.02069202
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.98709546
23	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.98069530
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.92881777
25	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.90362405
26	P300_19829295_ChIP-Seq_ESCs_Human	1.82497191
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.79838878
28	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.77452253
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.75942685
30	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.71695031
31	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.65878577
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65202790
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64533133
34	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.64076563
35	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.64076563
36	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.63965081
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60395445
38	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.60339550
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59978907
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.59656314
41	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59316368
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57509782
43	EWS_26573619_Chip-Seq_HEK293_Human	1.55063411
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54421675
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.54309625
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.52405005
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52000730
48	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.51506025
49	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.51124254
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49027371
51	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.47864254
52	STAT3_23295773_ChIP-Seq_U87_Human	1.46618740
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46562470
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43188303
55	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.42275391
56	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.40570519
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39546608
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37337780
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.36540970
60	AR_25329375_ChIP-Seq_VCAP_Human	1.36177452
61	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.34134920
62	TP53_16413492_ChIP-PET_HCT116_Human	1.33650985
63	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.33069712
64	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32370477
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30987310
66	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28386707
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28077862
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26736832
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26736832
70	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.25754945
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25224614
72	TCF4_23295773_ChIP-Seq_U87_Human	1.24585657
73	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20738177
74	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.19895061
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19315768
76	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18635598
77	HTT_18923047_ChIP-ChIP_STHdh_Human	1.17208482
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16762670
79	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.15746607
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14422441
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.14422441
82	JUN_21703547_ChIP-Seq_K562_Human	1.13691129
83	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13107240
84	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.11399671
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.11126251
86	SOX9_26525672_Chip-Seq_HEART_Mouse	1.10198336
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10193307
88	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.07393538
89	DROSHA_22980978_ChIP-Seq_HELA_Human	1.06606496
90	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.06079505
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05995697
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04098356
93	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.02980482
94	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02582466
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02004404
96	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99827117
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99516030
98	KDM2B_26808549_Chip-Seq_REH_Human	0.99043669
99	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.97220508
100	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.96672327

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.94787048
2	MP0000569_abnormal_digit_pigmentation	3.54694802
3	MP0008877_abnormal_DNA_methylation	3.30671781
4	MP0003787_abnormal_imprinting	3.30362501
5	MP0003880_abnormal_central_pattern	3.10555457
6	MP0006292_abnormal_olfactory_placode	2.97992614
7	MP0005423_abnormal_somatic_nervous	2.47064080
8	MP0009745_abnormal_behavioral_response	2.37428698
9	MP0003635_abnormal_synaptic_transmissio	2.31754573
10	MP0000566_synostosis	2.31313922
11	MP0004885_abnormal_endolymph	2.24361959
12	MP0002653_abnormal_ependyma_morphology	2.18042196
13	MP0009046_muscle_twitch	2.14379969
14	MP0002638_abnormal_pupillary_reflex	2.13299490
15	MP0004859_abnormal_synaptic_plasticity	2.10278448
16	MP0002064_seizures	2.09933663
17	MP0005551_abnormal_eye_electrophysiolog	2.05245695
18	MP0002572_abnormal_emotion/affect_behav	2.04095717
19	MP0002272_abnormal_nervous_system	2.03130164
20	MP0001968_abnormal_touch/_nociception	1.95546700
21	MP0000778_abnormal_nervous_system	1.92245245
22	MP0000631_abnormal_neuroendocrine_gland	1.90461207
23	MP0001485_abnormal_pinna_reflex	1.80207592
24	MP0002938_white_spotting	1.78703897
25	MP0001486_abnormal_startle_reflex	1.77501937
26	MP0003122_maternal_imprinting	1.73346854
27	MP0005646_abnormal_pituitary_gland	1.72264705
28	MP0002063_abnormal_learning/memory/cond	1.70358071
29	MP0008789_abnormal_olfactory_epithelium	1.69564336
30	MP0000955_abnormal_spinal_cord	1.68973521
31	MP0005187_abnormal_penis_morphology	1.67972654
32	MP0004742_abnormal_vestibular_system	1.67607928
33	MP0004133_heterotaxia	1.63149769
34	MP0003121_genomic_imprinting	1.59960102
35	MP0002736_abnormal_nociception_after	1.57668057
36	MP0002557_abnormal_social/conspecific_i	1.56209400
37	MP0002067_abnormal_sensory_capabilities	1.54754647
38	MP0005386_behavior/neurological_phenoty	1.49732743
39	MP0004924_abnormal_behavior	1.49732743
40	MP0002734_abnormal_mechanical_nocicepti	1.49697984
41	MP0006072_abnormal_retinal_apoptosis	1.44837580
42	MP0000026_abnormal_inner_ear	1.43263678
43	MP0001970_abnormal_pain_threshold	1.35130395
44	MP0005499_abnormal_olfactory_system	1.32623729
45	MP0005394_taste/olfaction_phenotype	1.32623729
46	MP0003195_calcinosis	1.30758103
47	MP0004270_analgesia	1.29054166
48	MP0005084_abnormal_gallbladder_morpholo	1.27128034
49	MP0002735_abnormal_chemical_nociception	1.26540623
50	MP0004142_abnormal_muscle_tone	1.24736154
51	MP0005195_abnormal_posterior_eye	1.20311676
52	MP0001963_abnormal_hearing_physiology	1.20041952
53	MP0002882_abnormal_neuron_morphology	1.19887655
54	MP0001986_abnormal_taste_sensitivity	1.19077128
55	MP0001905_abnormal_dopamine_level	1.18733066
56	MP0002102_abnormal_ear_morphology	1.17838189
57	MP0002733_abnormal_thermal_nociception	1.17668806
58	MP0002752_abnormal_somatic_nervous	1.17331120
59	MP0002184_abnormal_innervation	1.15775690
60	MP0000647_abnormal_sebaceous_gland	1.13818744
61	MP0001440_abnormal_grooming_behavior	1.11727825
62	MP0006276_abnormal_autonomic_nervous	1.11605508
63	MP0010386_abnormal_urinary_bladder	1.11230584
64	MP0005253_abnormal_eye_physiology	1.11184250
65	MP0003011_delayed_dark_adaptation	1.08872039
66	MP0001984_abnormal_olfaction	1.08621127
67	MP0004043_abnormal_pH_regulation	1.05489334
68	MP0005085_abnormal_gallbladder_physiolo	1.04294480
69	MP0002152_abnormal_brain_morphology	1.02156327
70	MP0001529_abnormal_vocalization	1.00649966
71	MP0002066_abnormal_motor_capabilities/c	0.95702322
72	MP0002928_abnormal_bile_duct	0.94199546
73	MP0000049_abnormal_middle_ear	0.93526608
74	MP0001501_abnormal_sleep_pattern	0.93255081
75	MP0005645_abnormal_hypothalamus_physiol	0.92939021
76	MP0002751_abnormal_autonomic_nervous	0.91815578
77	MP0008875_abnormal_xenobiotic_pharmacok	0.89308942
78	MP0002229_neurodegeneration	0.88107968
79	MP0002234_abnormal_pharynx_morphology	0.85656338
80	MP0000427_abnormal_hair_cycle	0.85581449
81	MP0008872_abnormal_physiological_respon	0.84905635
82	MP0002095_abnormal_skin_pigmentation	0.83700213
83	MP0002837_dystrophic_cardiac_calcinosis	0.82876640
84	MP0005171_absent_coat_pigmentation	0.82521934
85	MP0003938_abnormal_ear_development	0.81847304
86	MP0009780_abnormal_chondrocyte_physiolo	0.80392650
87	MP0004811_abnormal_neuron_physiology	0.79213279
88	MP0001324_abnormal_eye_pigmentation	0.79166277
89	MP0005257_abnormal_intraocular_pressure	0.78250877
90	MP0001502_abnormal_circadian_rhythm	0.76694412
91	MP0003633_abnormal_nervous_system	0.75399086
92	MP0002282_abnormal_trachea_morphology	0.75281196
93	MP0005391_vision/eye_phenotype	0.74774091
94	MP0002069_abnormal_eating/drinking_beha	0.73290892
95	MP0002249_abnormal_larynx_morphology	0.72437817
96	MP0001944_abnormal_pancreas_morphology	0.72394032
97	MP0000639_abnormal_adrenal_gland	0.72326311
98	MP0003119_abnormal_digestive_system	0.71174257
99	MP0003861_abnormal_nervous_system	0.71123472
100	MP0000613_abnormal_salivary_gland	0.70623992

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.05062111
2	True hermaphroditism (HP:0010459)	3.72520776
3	Pancreatic fibrosis (HP:0100732)	3.70272165
4	Abnormality of midbrain morphology (HP:0002418)	3.63994120
5	Molar tooth sign on MRI (HP:0002419)	3.63994120
6	Focal motor seizures (HP:0011153)	3.54976011
7	Progressive cerebellar ataxia (HP:0002073)	3.44346179
8	Hemiparesis (HP:0001269)	3.36082694
9	Nephronophthisis (HP:0000090)	3.34963650
10	Gaze-evoked nystagmus (HP:0000640)	3.29737281
11	Febrile seizures (HP:0002373)	3.28786243
12	Pancreatic cysts (HP:0001737)	3.25377331
13	Medial flaring of the eyebrow (HP:0010747)	3.17732857
14	Gait imbalance (HP:0002141)	3.17460934
15	Bilateral sensorineural hearing impairment (HP:0008619)	3.06458500
16	Focal seizures (HP:0007359)	2.89694239
17	Atonic seizures (HP:0010819)	2.81123107
18	Abnormality of the renal medulla (HP:0100957)	2.79023643
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.70360151
20	Absent/shortened dynein arms (HP:0200106)	2.70360151
21	Optic nerve hypoplasia (HP:0000609)	2.70329961
22	Congenital primary aphakia (HP:0007707)	2.68676783
23	Oligodactyly (hands) (HP:0001180)	2.63008065
24	Myokymia (HP:0002411)	2.53919068
25	Genetic anticipation (HP:0003743)	2.52466130
26	Broad-based gait (HP:0002136)	2.49489394
27	Drooling (HP:0002307)	2.47117435
28	Septo-optic dysplasia (HP:0100842)	2.46455044
29	Abnormality of the diencephalon (HP:0010662)	2.44083983
30	Congenital stationary night blindness (HP:0007642)	2.43761196
31	Nephrogenic diabetes insipidus (HP:0009806)	2.40240117
32	Cystic liver disease (HP:0006706)	2.37230249
33	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.32525872
34	Humeroradial synostosis (HP:0003041)	2.29448252
35	Synostosis involving the elbow (HP:0003938)	2.29448252
36	Abnormality of the renal cortex (HP:0011035)	2.28517752
37	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.25758315
38	Hypoplasia of the fovea (HP:0007750)	2.25758315
39	Volvulus (HP:0002580)	2.25520583
40	Lissencephaly (HP:0001339)	2.25286851
41	Epileptic encephalopathy (HP:0200134)	2.23782962
42	Tubulointerstitial nephritis (HP:0001970)	2.23509771
43	Excessive salivation (HP:0003781)	2.22740889
44	Epileptiform EEG discharges (HP:0011182)	2.22206249
45	Absence seizures (HP:0002121)	2.22120128
46	Inability to walk (HP:0002540)	2.19989566
47	Genital tract atresia (HP:0001827)	2.18755871
48	Oligodactyly (HP:0012165)	2.18577445
49	Renal cortical cysts (HP:0000803)	2.18507553
50	Large for gestational age (HP:0001520)	2.16711876
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14407130
52	Specific learning disability (HP:0001328)	2.14294190
53	Congenital sensorineural hearing impairment (HP:0008527)	2.13917772
54	Type II lissencephaly (HP:0007260)	2.12835730
55	Anencephaly (HP:0002323)	2.11847243
56	Postaxial hand polydactyly (HP:0001162)	2.11543022
57	Abnormality of the fovea (HP:0000493)	2.10454121
58	Dialeptic seizures (HP:0011146)	2.08995066
59	Generalized tonic-clonic seizures (HP:0002069)	2.07492963
60	Ulnar claw (HP:0001178)	2.07360079
61	Absent speech (HP:0001344)	2.04414373
62	Sclerocornea (HP:0000647)	2.03831863
63	Poor coordination (HP:0002370)	2.03001605
64	Esophageal atresia (HP:0002032)	2.02964879
65	Vaginal atresia (HP:0000148)	2.01280068
66	Postaxial foot polydactyly (HP:0001830)	2.00388885
67	EEG with generalized epileptiform discharges (HP:0011198)	1.99551780
68	Shawl scrotum (HP:0000049)	1.99226491
69	Aplasia/Hypoplasia of the lens (HP:0008063)	1.98713184
70	Hemiplegia (HP:0002301)	1.97280215
71	Tented upper lip vermilion (HP:0010804)	1.96061952
72	Hypsarrhythmia (HP:0002521)	1.95863469
73	Gastrointestinal atresia (HP:0002589)	1.95119455
74	Abnormal ciliary motility (HP:0012262)	1.94682416
75	Congenital hepatic fibrosis (HP:0002612)	1.94150610
76	Progressive inability to walk (HP:0002505)	1.93381803
77	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.91997242
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91564272
79	Protruding tongue (HP:0010808)	1.91467075
80	Morphological abnormality of the inner ear (HP:0011390)	1.89946085
81	Chronic hepatic failure (HP:0100626)	1.88825087
82	Broad foot (HP:0001769)	1.88539026
83	Polyphagia (HP:0002591)	1.88341736
84	Generalized myoclonic seizures (HP:0002123)	1.88084800
85	Decreased central vision (HP:0007663)	1.87590411
86	Action tremor (HP:0002345)	1.85875196
87	Pendular nystagmus (HP:0012043)	1.82140605
88	Abnormality of dentin (HP:0010299)	1.82103186
89	Limb dystonia (HP:0002451)	1.79746848
90	Status epilepticus (HP:0002133)	1.79460130
91	Male pseudohermaphroditism (HP:0000037)	1.78416144
92	Median cleft lip (HP:0000161)	1.77467994
93	Anophthalmia (HP:0000528)	1.75604294
94	Pachygyria (HP:0001302)	1.75007645
95	Brushfield spots (HP:0001088)	1.74519393
96	Abnormality of the 4th metacarpal (HP:0010012)	1.73501889
97	Fair hair (HP:0002286)	1.73056672
98	Agitation (HP:0000713)	1.72978009
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.72870921
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.72870921

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.71866898
2	TNIK	4.27048397
3	CASK	3.90879327
4	MAPK15	3.29642465
5	NTRK2	3.16026410
6	MARK1	3.11274802
7	MAPK13	2.99785934
8	FRK	2.80360737
9	NTRK3	2.61246520
10	WNK3	2.20037917
11	TSSK6	1.95994463
12	NEK1	1.81560305
13	UHMK1	1.81137010
14	EPHA4	1.77484666
15	MAP3K4	1.74725934
16	BMPR1B	1.74231462
17	MAP4K2	1.71543741
18	WEE1	1.68925708
19	GRK1	1.64844567
20	MAP2K7	1.57558471
21	SGK2	1.51945813
22	PINK1	1.41886457
23	MAPKAPK5	1.40716324
24	SGK494	1.38304928
25	SGK223	1.38304928
26	PRKCG	1.38051956
27	TAOK1	1.33004559
28	STK39	1.26533272
29	PAK3	1.26205950
30	PTK2B	1.25678198
31	CAMKK2	1.22737275
32	INSRR	1.22241983
33	PLK2	1.21795930
34	PHKG2	1.19812955
35	PHKG1	1.19812955
36	PAK6	1.14398597
37	DYRK2	1.02314296
38	MKNK2	1.00952508
39	WNK4	0.97853337
40	TAOK3	0.96615236
41	CSNK1G2	0.95481174
42	ADRBK2	0.93733791
43	MAPKAPK3	0.86660766
44	NUAK1	0.85679369
45	PKN1	0.84854362
46	VRK1	0.84734661
47	SGK1	0.80850838
48	MINK1	0.78967275
49	CAMK2A	0.78835625
50	MAP2K4	0.77535572
51	CAMK1G	0.76236317
52	OXSR1	0.75434404
53	NTRK1	0.74683614
54	CAMK2B	0.74626197
55	DMPK	0.74319822
56	CDK3	0.73163481
57	FGFR2	0.72571252
58	CAMK1D	0.65032848
59	EPHA3	0.64833164
60	DAPK2	0.62473540
61	IRAK2	0.61456787
62	SGK3	0.60700376
63	CSNK1A1	0.59569686
64	CSNK1G1	0.56487864
65	TAF1	0.56357806
66	PRKCE	0.55567632
67	TYRO3	0.54550454
68	CSNK1D	0.52089163
69	PLK4	0.51776463
70	PIK3CA	0.51554612
71	ERBB3	0.51532130
72	PRKCZ	0.49421494
73	MAP3K9	0.49250538
74	STK38	0.49183893
75	ACVR1B	0.49034061
76	NEK2	0.48810292
77	PRKG1	0.48752745
78	CSNK1G3	0.48498197
79	CSNK1A1L	0.48110538
80	LIMK1	0.48093532
81	CAMK2D	0.44828167
82	PRKACA	0.44442205
83	CSNK1E	0.42414567
84	TLK1	0.42018139
85	STK11	0.41628215
86	SIK2	0.40731855
87	CDK5	0.40062171
88	TNK2	0.37990096
89	EPHB2	0.34592009
90	RPS6KA3	0.34372346
91	CAMK1	0.34273532
92	PRKACB	0.33441957
93	PRKCQ	0.32436332
94	ADRBK1	0.31415180
95	TGFBR1	0.31372008
96	MKNK1	0.28657503
97	CAMKK1	0.28072569
98	CAMK4	0.27482963
99	ROCK1	0.24487215
100	KSR1	0.23892447

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.05569627
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.53707727
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.89967380
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.79476431
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24449016
6	Butanoate metabolism_Homo sapiens_hsa00650	2.23386841
7	Morphine addiction_Homo sapiens_hsa05032	2.09643231
8	Taste transduction_Homo sapiens_hsa04742	2.06096724
9	Phototransduction_Homo sapiens_hsa04744	2.02933747
10	GABAergic synapse_Homo sapiens_hsa04727	1.99284655
11	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96832425
12	Circadian entrainment_Homo sapiens_hsa04713	1.84572352
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.83750131
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.83740658
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.83493591
16	Glutamatergic synapse_Homo sapiens_hsa04724	1.78445317
17	Insulin secretion_Homo sapiens_hsa04911	1.76842971
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.76256932
19	Cocaine addiction_Homo sapiens_hsa05030	1.59902463
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.58310557
21	Amphetamine addiction_Homo sapiens_hsa05031	1.57035999
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52039999
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.51882548
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50511887
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46887237
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.29098572
27	Salivary secretion_Homo sapiens_hsa04970	1.28729781
28	Olfactory transduction_Homo sapiens_hsa04740	1.25378821
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.24234839
30	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.16168147
31	Axon guidance_Homo sapiens_hsa04360	1.15404692
32	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.14240436
33	Long-term depression_Homo sapiens_hsa04730	1.13138822
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.10868323
35	Propanoate metabolism_Homo sapiens_hsa00640	1.09893929
36	Serotonergic synapse_Homo sapiens_hsa04726	1.09665863
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08518817
38	Parkinsons disease_Homo sapiens_hsa05012	1.07477594
39	Histidine metabolism_Homo sapiens_hsa00340	1.07433949
40	Peroxisome_Homo sapiens_hsa04146	1.06933844
41	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.05205564
42	Calcium signaling pathway_Homo sapiens_hsa04020	1.04148802
43	Sulfur relay system_Homo sapiens_hsa04122	1.02637512
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.01537984
45	Cholinergic synapse_Homo sapiens_hsa04725	1.01356209
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.00071923
47	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.97579160
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95630566
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.95440214
50	Gastric acid secretion_Homo sapiens_hsa04971	0.93709173
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91705836
52	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.90682441
53	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.88019667
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85941589
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84357863
56	Renin secretion_Homo sapiens_hsa04924	0.84215544
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81068681
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79749589
59	Retinol metabolism_Homo sapiens_hsa00830	0.79618047
60	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.79617260
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.77720335
62	Folate biosynthesis_Homo sapiens_hsa00790	0.77465012
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.75095665
64	Long-term potentiation_Homo sapiens_hsa04720	0.74811653
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74251663
66	Alzheimers disease_Homo sapiens_hsa05010	0.72015518
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71094138
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69737424
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69079934
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.68733536
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.68659514
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68448020
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.68341428
74	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.68219021
75	Basal cell carcinoma_Homo sapiens_hsa05217	0.66395495
76	Bile secretion_Homo sapiens_hsa04976	0.66171900
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65978583
78	Pancreatic secretion_Homo sapiens_hsa04972	0.64256465
79	Estrogen signaling pathway_Homo sapiens_hsa04915	0.63953905
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61501907
81	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.61489881
82	Huntingtons disease_Homo sapiens_hsa05016	0.60946331
83	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59690466
84	Fatty acid degradation_Homo sapiens_hsa00071	0.58562819
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.56727603
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52479429
87	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.50690898
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48622455
89	Protein export_Homo sapiens_hsa03060	0.48482391
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.48284106
91	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.47397441
92	Caffeine metabolism_Homo sapiens_hsa00232	0.46087543
93	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44100181
94	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.43108813
95	Gap junction_Homo sapiens_hsa04540	0.43008518
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.38737156
97	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.37646112
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.37073552
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35030545
100	ABC transporters_Homo sapiens_hsa02010	0.34553513

ANKRD20A7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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