ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	kynurenine metabolic process (GO:0070189)	5.33019534
2	tryptophan catabolic process (GO:0006569)	4.87351720
3	indole-containing compound catabolic process (GO:0042436)	4.87351720
4	indolalkylamine catabolic process (GO:0046218)	4.87351720
5	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.71165153
6	indolalkylamine metabolic process (GO:0006586)	4.58029668
7	tryptophan metabolic process (GO:0006568)	4.34083552
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.31451917
9	synapsis (GO:0007129)	4.31043756
10	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.92226809
11	reflex (GO:0060004)	3.85993323
12	amine catabolic process (GO:0009310)	3.83080743
13	cellular biogenic amine catabolic process (GO:0042402)	3.83080743
14	DNA methylation involved in gamete generation (GO:0043046)	3.76746495
15	piRNA metabolic process (GO:0034587)	3.72232273
16	membrane repolarization during action potential (GO:0086011)	3.63897568
17	regulation of establishment of cell polarity (GO:2000114)	3.55557147
18	auditory receptor cell stereocilium organization (GO:0060088)	3.52753793
19	regulation of hippo signaling (GO:0035330)	3.47831802
20	indole-containing compound metabolic process (GO:0042430)	3.47793203
21	behavioral response to nicotine (GO:0035095)	3.47374178
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.44577391
23	detection of light stimulus involved in visual perception (GO:0050908)	3.44577391
24	meiotic chromosome segregation (GO:0045132)	3.44319082
25	cilium or flagellum-dependent cell motility (GO:0001539)	3.42297353
26	fucose catabolic process (GO:0019317)	3.39439254
27	L-fucose metabolic process (GO:0042354)	3.39439254
28	L-fucose catabolic process (GO:0042355)	3.39439254
29	aromatic amino acid family catabolic process (GO:0009074)	3.38467547
30	interkinetic nuclear migration (GO:0022027)	3.36856722
31	male meiosis (GO:0007140)	3.30601843
32	snRNA transcription (GO:0009301)	3.29907733
33	startle response (GO:0001964)	3.21761259
34	regulation of cilium movement (GO:0003352)	3.20035746
35	acrosome assembly (GO:0001675)	3.18574106
36	cellular ketone body metabolic process (GO:0046950)	3.15340874
37	benzene-containing compound metabolic process (GO:0042537)	3.15175662
38	photoreceptor cell maintenance (GO:0045494)	3.14752667
39	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.11959273
40	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.11959273
41	cellular response to ATP (GO:0071318)	3.11314098
42	DNA replication checkpoint (GO:0000076)	3.10422391
43	ketone body metabolic process (GO:1902224)	3.07464710
44	regulation of neurotransmitter uptake (GO:0051580)	3.06616634
45	dopamine transport (GO:0015872)	3.06489744
46	aromatic amino acid family metabolic process (GO:0009072)	3.05563164
47	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.03459548
48	reciprocal DNA recombination (GO:0035825)	2.99243507
49	reciprocal meiotic recombination (GO:0007131)	2.99243507
50	vitamin transmembrane transport (GO:0035461)	2.97496777
51	magnesium ion transport (GO:0015693)	2.97306232
52	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.96794431
53	signal peptide processing (GO:0006465)	2.96215791
54	rRNA catabolic process (GO:0016075)	2.95879523
55	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.93391792
56	positive regulation of steroid hormone secretion (GO:2000833)	2.91508605
57	multicellular organism reproduction (GO:0032504)	2.90474798
58	NAD biosynthetic process (GO:0009435)	2.88342435
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.86462473
60	peristalsis (GO:0030432)	2.86426794
61	potassium ion export (GO:0071435)	2.84198948
62	serotonin metabolic process (GO:0042428)	2.82148009
63	organic cation transport (GO:0015695)	2.80654822
64	recombinational repair (GO:0000725)	2.80537772
65	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.79159009
66	double-strand break repair via homologous recombination (GO:0000724)	2.77723248
67	phasic smooth muscle contraction (GO:0014821)	2.74401915
68	sperm motility (GO:0030317)	2.73144396
69	endosome to melanosome transport (GO:0035646)	2.72864981
70	endosome to pigment granule transport (GO:0043485)	2.72864981
71	negative regulation of sodium ion transport (GO:0010766)	2.72446824
72	neuronal action potential (GO:0019228)	2.71784837
73	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68926240
74	keratinocyte development (GO:0003334)	2.68267620
75	regulation of hexokinase activity (GO:1903299)	2.67896770
76	regulation of glucokinase activity (GO:0033131)	2.67896770
77	male meiosis I (GO:0007141)	2.67580602
78	methionine biosynthetic process (GO:0009086)	2.66418567
79	protein import into peroxisome matrix (GO:0016558)	2.66317042
80	response to pheromone (GO:0019236)	2.64345104
81	righting reflex (GO:0060013)	2.61281155
82	primary amino compound metabolic process (GO:1901160)	2.60965871
83	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.58622047
84	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.57694889
85	membrane depolarization during action potential (GO:0086010)	2.55825756
86	positive regulation of glycolytic process (GO:0045821)	2.54674442
87	cellular response to sterol (GO:0036315)	2.53443423
88	flavonoid metabolic process (GO:0009812)	2.51842421
89	regulation of steroid hormone secretion (GO:2000831)	2.51648510
90	neuronal action potential propagation (GO:0019227)	2.51392006
91	replication fork processing (GO:0031297)	2.50740449
92	chromosome organization involved in meiosis (GO:0070192)	2.50492199
93	inner ear receptor stereocilium organization (GO:0060122)	2.49832838
94	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49067847
95	thyroid hormone metabolic process (GO:0042403)	2.48997561
96	resolution of meiotic recombination intermediates (GO:0000712)	2.48384724
97	musculoskeletal movement (GO:0050881)	2.47724443
98	multicellular organismal movement (GO:0050879)	2.47724443
99	sulfation (GO:0051923)	2.45420988
100	polyol catabolic process (GO:0046174)	2.45135819

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.10884401
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.87446319
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.40433886
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.08609031
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.65623822
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.58676480
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.55680058
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43227553
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.23646669
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.23055425
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.18155320
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.15373853
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.11618971
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.09905575
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.09818246
16	EZH2_22144423_ChIP-Seq_EOC_Human	1.99373421
17	P300_19829295_ChIP-Seq_ESCs_Human	1.99202960
18	FUS_26573619_Chip-Seq_HEK293_Human	1.95583398
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92355808
20	STAT3_23295773_ChIP-Seq_U87_Human	1.91652127
21	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.91047332
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.90513642
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.87869656
24	EWS_26573619_Chip-Seq_HEK293_Human	1.87719874
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.82936130
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.79240889
27	TCF4_23295773_ChIP-Seq_U87_Human	1.77789757
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76463904
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76422509
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.75448724
31	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.66776982
32	AR_25329375_ChIP-Seq_VCAP_Human	1.65253603
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54510034
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53884990
35	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.53516913
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52296120
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52296120
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49249309
39	RUNX2_22187159_ChIP-Seq_PCA_Human	1.45601962
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42593557
41	TCF4_22108803_ChIP-Seq_LS180_Human	1.42040725
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.40238777
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40238777
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40078268
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.36868247
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36560185
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.36554256
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36331226
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35886786
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35750368
51	TP53_16413492_ChIP-PET_HCT116_Human	1.34909297
52	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.34836145
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34395928
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34395928
55	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33973443
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33940988
57	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.33632570
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29308496
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29189987
60	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27705865
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27597764
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27467624
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27043815
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27043815
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26625594
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25785343
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24825090
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.24672657
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23838907
70	GATA1_22025678_ChIP-Seq_K562_Human	1.23357184
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21687936
72	E2F7_22180533_ChIP-Seq_HELA_Human	1.21253756
73	AR_21572438_ChIP-Seq_LNCaP_Human	1.20876545
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19340738
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18239055
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17582601
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17308636
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14761767
79	NFYB_21822215_ChIP-Seq_K562_Human	1.11399714
80	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11094027
81	TBL1_22424771_ChIP-Seq_293T_Human	1.08927944
82	ETV1_20927104_ChIP-Seq_GIST48_Human	1.07717904
83	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.06130369
84	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05979116
85	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.05691494
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05511785
87	AR_20517297_ChIP-Seq_VCAP_Human	1.05197375
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03717725
89	RXR_22108803_ChIP-Seq_LS180_Human	1.03509838
90	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03276193
91	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01941980
92	NFYA_21822215_ChIP-Seq_K562_Human	1.01507533
93	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01222980
94	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01045966
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00664420
96	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.00428321
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99428148
98	NCOR_22424771_ChIP-Seq_293T_Human	0.98272250
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98014391
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97653992

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.74526742
2	MP0003878_abnormal_ear_physiology	3.69117117
3	MP0005377_hearing/vestibular/ear_phenot	3.69117117
4	MP0003136_yellow_coat_color	3.52946336
5	MP0000372_irregular_coat_pigmentation	2.94727722
6	MP0003806_abnormal_nucleotide_metabolis	2.76385511
7	MP0009046_muscle_twitch	2.72748704
8	MP0000569_abnormal_digit_pigmentation	2.68725142
9	MP0008877_abnormal_DNA_methylation	2.49866875
10	MP0001485_abnormal_pinna_reflex	2.33092070
11	MP0005551_abnormal_eye_electrophysiolog	2.32471421
12	MP0001968_abnormal_touch/_nociception	2.20335675
13	MP0003950_abnormal_plasma_membrane	2.09892150
14	MP0005410_abnormal_fertilization	2.04919814
15	MP0001501_abnormal_sleep_pattern	2.04705893
16	MP0002160_abnormal_reproductive_system	2.02156728
17	MP0000383_abnormal_hair_follicle	1.91751708
18	MP0008057_abnormal_DNA_replication	1.89245330
19	MP0004215_abnormal_myocardial_fiber	1.87545890
20	MP0003646_muscle_fatigue	1.86527537
21	MP0005451_abnormal_body_composition	1.83817077
22	MP0000427_abnormal_hair_cycle	1.83611387
23	MP0002837_dystrophic_cardiac_calcinosis	1.82190598
24	MP0002736_abnormal_nociception_after	1.80784000
25	MP0005360_urolithiasis	1.78266418
26	MP0008872_abnormal_physiological_respon	1.72183759
27	MP0002638_abnormal_pupillary_reflex	1.70546128
28	MP0008775_abnormal_heart_ventricle	1.68041799
29	MP0000647_abnormal_sebaceous_gland	1.68031018
30	MP0001486_abnormal_startle_reflex	1.64660352
31	MP0005174_abnormal_tail_pigmentation	1.64459228
32	MP0004043_abnormal_pH_regulation	1.62965018
33	MP0005408_hypopigmentation	1.62104431
34	MP0006276_abnormal_autonomic_nervous	1.55399346
35	MP0005389_reproductive_system_phenotype	1.54276448
36	MP0005646_abnormal_pituitary_gland	1.54197069
37	MP0005171_absent_coat_pigmentation	1.52995237
38	MP0002095_abnormal_skin_pigmentation	1.51071504
39	MP0009697_abnormal_copulation	1.50748990
40	MP0009745_abnormal_behavioral_response	1.49285193
41	MP0005253_abnormal_eye_physiology	1.30669409
42	MP0003718_maternal_effect	1.29250334
43	MP0002735_abnormal_chemical_nociception	1.28156084
44	MP0002272_abnormal_nervous_system	1.23926238
45	MP0004147_increased_porphyrin_level	1.22512229
46	MP0009780_abnormal_chondrocyte_physiolo	1.22049704
47	MP0001986_abnormal_taste_sensitivity	1.20771379
48	MP0008875_abnormal_xenobiotic_pharmacok	1.18499117
49	MP0002938_white_spotting	1.18341608
50	MP0005075_abnormal_melanosome_morpholog	1.17679297
51	MP0002067_abnormal_sensory_capabilities	1.15365734
52	MP0005085_abnormal_gallbladder_physiolo	1.14901166
53	MP0003698_abnormal_male_reproductive	1.14193552
54	MP0002102_abnormal_ear_morphology	1.13794108
55	MP0002229_neurodegeneration	1.13280065
56	MP0010678_abnormal_skin_adnexa	1.13102062
57	MP0003137_abnormal_impulse_conducting	1.11575364
58	MP0002733_abnormal_thermal_nociception	1.10081865
59	MP0001929_abnormal_gametogenesis	1.09677636
60	MP0010094_abnormal_chromosome_stability	1.09403823
61	MP0010386_abnormal_urinary_bladder	1.09179278
62	MP0001919_abnormal_reproductive_system	1.09123717
63	MP0000230_abnormal_systemic_arterial	1.07480439
64	MP0000015_abnormal_ear_pigmentation	1.07095426
65	MP0005636_abnormal_mineral_homeostasis	1.06102201
66	MP0004145_abnormal_muscle_electrophysio	1.05487273
67	MP0004924_abnormal_behavior	1.03155091
68	MP0005386_behavior/neurological_phenoty	1.03155091
69	MP0003252_abnormal_bile_duct	1.03108759
70	MP0005645_abnormal_hypothalamus_physiol	1.03055467
71	MP0002876_abnormal_thyroid_physiology	1.02817409
72	MP0002572_abnormal_emotion/affect_behav	0.99495927
73	MP0000678_abnormal_parathyroid_gland	0.98533145
74	MP0004885_abnormal_endolymph	0.98492161
75	MP0002064_seizures	0.97940553
76	MP0004381_abnormal_hair_follicle	0.97590490
77	MP0004142_abnormal_muscle_tone	0.96693671
78	MP0001963_abnormal_hearing_physiology	0.96527672
79	MP0002928_abnormal_bile_duct	0.96030682
80	MP0002210_abnormal_sex_determination	0.93973053
81	MP0000371_diluted_coat_color	0.92434825
82	MP0000631_abnormal_neuroendocrine_gland	0.92057038
83	MP0000026_abnormal_inner_ear	0.90292002
84	MP0002557_abnormal_social/conspecific_i	0.89673981
85	MP0001664_abnormal_digestion	0.89140551
86	MP0004084_abnormal_cardiac_muscle	0.87403784
87	MP0001970_abnormal_pain_threshold	0.86814949
88	MP0003943_abnormal_hepatobiliary_system	0.86548948
89	MP0005187_abnormal_penis_morphology	0.86214255
90	MP0002693_abnormal_pancreas_physiology	0.86146984
91	MP0006072_abnormal_retinal_apoptosis	0.84566775
92	MP0000538_abnormal_urinary_bladder	0.84399781
93	MP0005266_abnormal_metabolism	0.83156972
94	MP0001324_abnormal_eye_pigmentation	0.81206955
95	MP0010329_abnormal_lipoprotein_level	0.81020443
96	MP0005332_abnormal_amino_acid	0.80814698
97	MP0004085_abnormal_heartbeat	0.79513255
98	MP0001765_abnormal_ion_homeostasis	0.78812782
99	MP0001873_stomach_inflammation	0.77649816
100	MP0003633_abnormal_nervous_system	0.73444000

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.35311221
2	Hyperventilation (HP:0002883)	4.22876240
3	True hermaphroditism (HP:0010459)	4.18670336
4	Pancreatic fibrosis (HP:0100732)	4.17107957
5	Molar tooth sign on MRI (HP:0002419)	3.98858037
6	Abnormality of midbrain morphology (HP:0002418)	3.98858037
7	Cerebellar dysplasia (HP:0007033)	3.85758269
8	Birth length less than 3rd percentile (HP:0003561)	3.84421246
9	Gaze-evoked nystagmus (HP:0000640)	3.82500752
10	Protruding tongue (HP:0010808)	3.55105421
11	Congenital stationary night blindness (HP:0007642)	3.49493600
12	Large for gestational age (HP:0001520)	3.19750751
13	Abnormality of the renal cortex (HP:0011035)	3.19011590
14	Nephronophthisis (HP:0000090)	3.03744017
15	Attenuation of retinal blood vessels (HP:0007843)	3.01418425
16	Cystic liver disease (HP:0006706)	2.98511406
17	Furrowed tongue (HP:0000221)	2.97939091
18	Renal cortical cysts (HP:0000803)	2.96112646
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.90620426
20	Absent/shortened dynein arms (HP:0200106)	2.90620426
21	Type II lissencephaly (HP:0007260)	2.88981605
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.88040111
23	Abnormality of alanine metabolism (HP:0010916)	2.88040111
24	Hyperalaninemia (HP:0003348)	2.88040111
25	Congenital sensorineural hearing impairment (HP:0008527)	2.83541471
26	Hypoplasia of the fovea (HP:0007750)	2.78467951
27	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.78467951
28	Ventricular fibrillation (HP:0001663)	2.73023605
29	Genetic anticipation (HP:0003743)	2.71860199
30	Abnormality of the renal medulla (HP:0100957)	2.71015588
31	Inability to walk (HP:0002540)	2.70278967
32	Fair hair (HP:0002286)	2.64308014
33	Clumsiness (HP:0002312)	2.46165331
34	Generalized hypopigmentation of hair (HP:0011358)	2.44026846
35	Absent speech (HP:0001344)	2.42891420
36	Congenital hepatic fibrosis (HP:0002612)	2.41685617
37	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.40465264
38	Dysmetric saccades (HP:0000641)	2.31727349
39	Medial flaring of the eyebrow (HP:0010747)	2.29176882
40	Progressive cerebellar ataxia (HP:0002073)	2.28494899
41	Progressive inability to walk (HP:0002505)	2.28212660
42	11 pairs of ribs (HP:0000878)	2.27444807
43	Febrile seizures (HP:0002373)	2.27315616
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26857601
45	Blue irides (HP:0000635)	2.26496496
46	Mesangial abnormality (HP:0001966)	2.24343917
47	Ketoacidosis (HP:0001993)	2.22955130
48	Male pseudohermaphroditism (HP:0000037)	2.18807421
49	Hypomagnesemia (HP:0002917)	2.18720769
50	Sclerocornea (HP:0000647)	2.17681800
51	Syncope (HP:0001279)	2.17526375
52	Decreased central vision (HP:0007663)	2.15003436
53	Abnormal ciliary motility (HP:0012262)	2.13905429
54	Hypoplastic labia majora (HP:0000059)	2.13834949
55	Volvulus (HP:0002580)	2.13435868
56	Cone-rod dystrophy (HP:0000548)	2.08434878
57	Abnormal respiratory epithelium morphology (HP:0012253)	2.07834270
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07834270
59	Abnormal drinking behavior (HP:0030082)	2.07180556
60	Polydipsia (HP:0001959)	2.07180556
61	Constricted visual fields (HP:0001133)	2.07019607
62	Increased corneal curvature (HP:0100692)	2.06985055
63	Keratoconus (HP:0000563)	2.06985055
64	Abnormality of the fovea (HP:0000493)	2.06340145
65	Decreased circulating renin level (HP:0003351)	2.02092832
66	Chromsome breakage (HP:0040012)	2.00950813
67	Albinism (HP:0001022)	1.99202201
68	Hypoplastic ischia (HP:0003175)	1.97575222
69	Abolished electroretinogram (ERG) (HP:0000550)	1.96997178
70	Chronic hepatic failure (HP:0100626)	1.95999016
71	Tetany (HP:0001281)	1.95588528
72	Concave nail (HP:0001598)	1.95408252
73	Hemiparesis (HP:0001269)	1.94798608
74	Gait imbalance (HP:0002141)	1.92958389
75	Severe muscular hypotonia (HP:0006829)	1.92909220
76	Abnormality of the labia majora (HP:0012881)	1.92755610
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.92394393
78	Tachypnea (HP:0002789)	1.92165120
79	Congenital primary aphakia (HP:0007707)	1.91752360
80	Broad-based gait (HP:0002136)	1.89195474
81	Patellar aplasia (HP:0006443)	1.87579020
82	Prolonged QT interval (HP:0001657)	1.86493567
83	Astigmatism (HP:0000483)	1.85577817
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.83710748
85	Congenital, generalized hypertrichosis (HP:0004540)	1.82941735
86	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.82675312
87	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.82675312
88	Recurrent corneal erosions (HP:0000495)	1.82220069
89	Nephrogenic diabetes insipidus (HP:0009806)	1.82005568
90	Widely spaced teeth (HP:0000687)	1.80718790
91	Ketosis (HP:0001946)	1.80716238
92	Aplasia/Hypoplasia of the macula (HP:0008059)	1.79162271
93	Small hand (HP:0200055)	1.78419571
94	Tubular atrophy (HP:0000092)	1.77090243
95	Anencephaly (HP:0002323)	1.75638838
96	Breast hypoplasia (HP:0003187)	1.75627356
97	Abnormal rod and cone electroretinograms (HP:0008323)	1.75452403
98	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73729558
99	Sloping forehead (HP:0000340)	1.72670118
100	Aplasia/Hypoplasia of the patella (HP:0006498)	1.72567150

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.39968714
2	NEK1	3.26329436
3	ACVR1B	3.24918558
4	ADRBK2	3.23768991
5	MAP3K13	3.23730381
6	BMPR1B	2.84815699
7	GRK1	2.40771450
8	NTRK3	2.36285099
9	ZAK	2.27894157
10	EIF2AK3	2.09090752
11	NEK2	1.92131440
12	MST4	1.89102507
13	PINK1	1.87043324
14	PNCK	1.64784769
15	MET	1.57542774
16	WEE1	1.54114712
17	NUAK1	1.42973577
18	INSRR	1.42349532
19	MAPK13	1.40362210
20	WNK4	1.39650280
21	TAOK3	1.38071628
22	PTK2B	1.35832937
23	TLK1	1.28253278
24	STK3	1.21927867
25	MAP3K7	1.20791388
26	MKNK2	1.18045706
27	WNK3	1.15614921
28	PLK4	1.12797990
29	PAK3	1.01935553
30	ADRBK1	1.01374481
31	FLT3	0.96972428
32	CASK	0.92839197
33	PRKAA2	0.88877478
34	TRPM7	0.86128484
35	TGFBR1	0.84921691
36	MAP3K2	0.84891285
37	STK39	0.83795081
38	DAPK2	0.83535653
39	OXSR1	0.83233778
40	BRSK2	0.82880095
41	KIT	0.81310174
42	MAP4K2	0.80331127
43	MUSK	0.79318997
44	NTRK2	0.78765899
45	PRKCG	0.76425129
46	MAPKAPK3	0.75262070
47	PLK2	0.72883073
48	WNK1	0.71895407
49	MAP2K1	0.70815558
50	PHKG1	0.69248216
51	PHKG2	0.69248216
52	PRKCE	0.65926144
53	FER	0.63247018
54	PIK3CA	0.62870061
55	TEC	0.60857345
56	CAMK2A	0.59380250
57	RPS6KB2	0.57548238
58	TNK2	0.56633558
59	CAMKK2	0.55580887
60	CHEK2	0.55548727
61	ATM	0.55050420
62	MAP3K14	0.54712857
63	MAP3K4	0.53689717
64	PRKAA1	0.52344327
65	MARK3	0.51777406
66	FGFR2	0.51128167
67	MAP2K6	0.50112647
68	PLK1	0.49370767
69	PIK3CG	0.47994369
70	CAMK2D	0.47651434
71	PKN1	0.47622448
72	MAPKAPK5	0.47033730
73	AKT3	0.46975914
74	CHUK	0.46882884
75	CAMK1D	0.46551882
76	PASK	0.44985296
77	TNIK	0.43224074
78	IKBKB	0.43044792
79	MAPK15	0.42504448
80	CSNK1D	0.40531596
81	STK38L	0.40506796
82	CCNB1	0.38931241
83	PRKACB	0.37491298
84	CAMK1G	0.37366877
85	BMPR2	0.36657919
86	EIF2AK2	0.34930342
87	ERBB2	0.34299643
88	PRKCQ	0.34131798
89	PDK2	0.33369301
90	RPS6KA5	0.32016198
91	PRKCA	0.29320036
92	MKNK1	0.27833447
93	SGK1	0.27700569
94	PAK6	0.27560565
95	PRKCH	0.27181820
96	PRKACA	0.26825199
97	ERBB3	0.26767516
98	CAMK1	0.26223466
99	PRKG2	0.24755178
100	TIE1	0.24629943

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	3.55139807
2	Butanoate metabolism_Homo sapiens_hsa00650	3.16208979
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.74948050
4	One carbon pool by folate_Homo sapiens_hsa00670	2.71284898
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.69497707
6	Homologous recombination_Homo sapiens_hsa03440	2.62669958
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37861781
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.37002661
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.19238659
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.06481281
11	Olfactory transduction_Homo sapiens_hsa04740	2.05784233
12	Phototransduction_Homo sapiens_hsa04744	1.96256369
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95285746
14	ABC transporters_Homo sapiens_hsa02010	1.93429573
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.85044942
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81555323
17	Nicotine addiction_Homo sapiens_hsa05033	1.78222495
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.72775137
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.63468140
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57489562
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54856422
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.51191707
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.50766673
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.47984099
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44182628
26	Circadian entrainment_Homo sapiens_hsa04713	1.39208959
27	Taste transduction_Homo sapiens_hsa04742	1.35848869
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.34886391
29	Peroxisome_Homo sapiens_hsa04146	1.32187685
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.31028388
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.30934245
32	Salivary secretion_Homo sapiens_hsa04970	1.29853235
33	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.29407630
34	Retinol metabolism_Homo sapiens_hsa00830	1.29000491
35	Morphine addiction_Homo sapiens_hsa05032	1.26462559
36	Insulin secretion_Homo sapiens_hsa04911	1.22222276
37	Caffeine metabolism_Homo sapiens_hsa00232	1.17246077
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15410351
39	Basal transcription factors_Homo sapiens_hsa03022	1.14488714
40	Serotonergic synapse_Homo sapiens_hsa04726	1.10881115
41	Glycerolipid metabolism_Homo sapiens_hsa00561	1.10715081
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09730747
43	Propanoate metabolism_Homo sapiens_hsa00640	1.09396195
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03596809
45	Mineral absorption_Homo sapiens_hsa04978	1.00457615
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99581309
47	Histidine metabolism_Homo sapiens_hsa00340	0.99267017
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96283267
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.95988278
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.95638957
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95507779
52	Circadian rhythm_Homo sapiens_hsa04710	0.94025245
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.93164479
54	Type II diabetes mellitus_Homo sapiens_hsa04930	0.92162767
55	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.91047352
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.87287763
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.83189421
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.82133599
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81943361
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81104826
61	Regulation of autophagy_Homo sapiens_hsa04140	0.78070583
62	GABAergic synapse_Homo sapiens_hsa04727	0.77402164
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77366769
64	Sphingolipid metabolism_Homo sapiens_hsa00600	0.76825242
65	Lysine degradation_Homo sapiens_hsa00310	0.72789832
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72638776
67	Purine metabolism_Homo sapiens_hsa00230	0.70745718
68	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65623164
69	RNA degradation_Homo sapiens_hsa03018	0.65612190
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.63890938
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60902104
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59436641
73	Long-term depression_Homo sapiens_hsa04730	0.56858631
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55999136
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.54806240
76	Gastric acid secretion_Homo sapiens_hsa04971	0.54404091
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.52799443
78	Fatty acid degradation_Homo sapiens_hsa00071	0.52124397
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50629166
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.50177712
81	Metabolic pathways_Homo sapiens_hsa01100	0.49625453
82	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46726396
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.45156150
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43760970
85	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43339317
86	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.40948814
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.39628869
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39199752
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38903927
90	Bile secretion_Homo sapiens_hsa04976	0.37115935
91	Amphetamine addiction_Homo sapiens_hsa05031	0.36521795
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36436304
93	RNA polymerase_Homo sapiens_hsa03020	0.34756899
94	Cholinergic synapse_Homo sapiens_hsa04725	0.34528340
95	Pancreatic secretion_Homo sapiens_hsa04972	0.33980843
96	Arginine biosynthesis_Homo sapiens_hsa00220	0.32573395
97	Platelet activation_Homo sapiens_hsa04611	0.32519222
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.31313203
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.31227604
100	Renin secretion_Homo sapiens_hsa04924	0.29196006

ANKRD20A8P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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