ANKRD20A9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.69100023
2acrosome reaction (GO:0007340)8.25909670
3fusion of sperm to egg plasma membrane (GO:0007342)7.21857772
4spermatid development (GO:0007286)6.86535165
5protein polyglutamylation (GO:0018095)6.60726972
6multicellular organism reproduction (GO:0032504)6.37785776
7regulation of cilium movement (GO:0003352)6.33136144
8protein targeting to Golgi (GO:0000042)6.23110762
9establishment of protein localization to Golgi (GO:0072600)6.22862497
10retrograde transport, vesicle recycling within Golgi (GO:0000301)5.81106075
11sperm-egg recognition (GO:0035036)5.55708765
12plasma membrane fusion (GO:0045026)5.53593316
13protein localization to Golgi apparatus (GO:0034067)5.50898828
14spermatid nucleus differentiation (GO:0007289)5.42417129
15motile cilium assembly (GO:0044458)5.34971300
16binding of sperm to zona pellucida (GO:0007339)5.13404135
17rRNA methylation (GO:0031167)5.09248578
18epithelial cilium movement (GO:0003351)5.08088319
19cilium or flagellum-dependent cell motility (GO:0001539)4.97532137
20axonemal dynein complex assembly (GO:0070286)4.96327522
21chromosome condensation (GO:0030261)4.93738833
22reproduction (GO:0000003)4.92377723
23organic cation transport (GO:0015695)4.92120502
24phosphatidylethanolamine biosynthetic process (GO:0006646)4.88416565
25male meiosis (GO:0007140)4.75929280
26single fertilization (GO:0007338)4.74575045
27regulation of phosphoprotein phosphatase activity (GO:0043666)4.71503079
28cell-cell recognition (GO:0009988)4.71213401
29microtubule depolymerization (GO:0007019)4.69961004
30rRNA modification (GO:0000154)4.63876516
31phosphatidylethanolamine metabolic process (GO:0046337)4.57498637
32DNA packaging (GO:0006323)4.52895675
33calcium ion-dependent exocytosis (GO:0017156)4.49246346
34male gamete generation (GO:0048232)4.42383995
35spermatogenesis (GO:0007283)4.41087906
36centriole replication (GO:0007099)4.41064213
37centriole assembly (GO:0098534)4.39007084
38response to pheromone (GO:0019236)4.38172920
39regulation of microtubule-based movement (GO:0060632)4.30639684
40microtubule polymerization or depolymerization (GO:0031109)4.27202401
41sperm capacitation (GO:0048240)4.26075933
42cellular ketone body metabolic process (GO:0046950)4.16773937
43gamete generation (GO:0007276)4.07515319
44cilium movement (GO:0003341)4.05804170
45germ cell development (GO:0007281)3.97008045
46ketone body metabolic process (GO:1902224)3.96144922
47single strand break repair (GO:0000012)3.94374827
48axoneme assembly (GO:0035082)3.84910241
49fertilization (GO:0009566)3.84383883
50positive regulation of glycolytic process (GO:0045821)3.66908006
51cellular process involved in reproduction in multicellular organism (GO:0022412)3.57623765
52seminiferous tubule development (GO:0072520)3.49545119
53regulation of centriole replication (GO:0046599)3.41271346
54acrosome assembly (GO:0001675)3.40510232
55piRNA metabolic process (GO:0034587)3.29140833
56multicellular organismal reproductive process (GO:0048609)3.22232746
57ventricular system development (GO:0021591)3.18037355
58negative regulation of inclusion body assembly (GO:0090084)3.12630781
59positive regulation of catecholamine secretion (GO:0033605)3.11022455
60DNA methylation involved in gamete generation (GO:0043046)3.08088298
61TOR signaling (GO:0031929)3.06433729
62centrosome duplication (GO:0051298)3.05033418
63synapsis (GO:0007129)3.03264145
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99987428
65peptidyl-glutamic acid modification (GO:0018200)2.98990356
66intra-Golgi vesicle-mediated transport (GO:0006891)2.97609962
67negative regulation of reactive oxygen species metabolic process (GO:2000378)2.94690524
68protein targeting to lysosome (GO:0006622)2.91979077
69establishment of protein localization to vacuole (GO:0072666)2.91979077
70protein targeting to vacuole (GO:0006623)2.91979077
71cilium organization (GO:0044782)2.89943761
72regulation of Rab GTPase activity (GO:0032313)2.89854347
73positive regulation of Rab GTPase activity (GO:0032851)2.89854347
74cilium assembly (GO:0042384)2.89186595
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86568301
76regulation of oxidative phosphorylation (GO:0002082)2.85212866
77coenzyme catabolic process (GO:0009109)2.83670840
78male sex determination (GO:0030238)2.79039667
79protein localization to cilium (GO:0061512)2.78948623
80detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.78832496
81dopamine transport (GO:0015872)2.77866902
82DNA double-strand break processing (GO:0000729)2.76248790
83regulation of meiosis I (GO:0060631)2.73504326
84microtubule severing (GO:0051013)2.73182874
85chromosome organization involved in meiosis (GO:0070192)2.71904177
86microtubule nucleation (GO:0007020)2.71386927
87genitalia morphogenesis (GO:0035112)2.69531117
88adaptation of signaling pathway (GO:0023058)2.69002429
89interleukin-6-mediated signaling pathway (GO:0070102)2.66760559
90nucleus organization (GO:0006997)2.63515589
91early endosome to late endosome transport (GO:0045022)2.62365096
92Golgi to endosome transport (GO:0006895)2.60533187
93protein-cofactor linkage (GO:0018065)2.59284984
94regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.52189544
95regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.52189544
96peristalsis (GO:0030432)2.49770855
97negative regulation of JUN kinase activity (GO:0043508)2.49714153
98meiotic nuclear division (GO:0007126)2.49295780
99regulation of growth hormone secretion (GO:0060123)2.46306426
100cellular zinc ion homeostasis (GO:0006882)2.46006481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.34458712
2IGF1R_20145208_ChIP-Seq_DFB_Human3.11729841
3VDR_22108803_ChIP-Seq_LS180_Human2.97403524
4GBX2_23144817_ChIP-Seq_PC3_Human2.82865788
5ER_23166858_ChIP-Seq_MCF-7_Human2.81524807
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.75957544
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.62117022
8FUS_26573619_Chip-Seq_HEK293_Human2.59555430
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.40958010
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33984873
11ZNF274_21170338_ChIP-Seq_K562_Hela2.27619918
12CBP_20019798_ChIP-Seq_JUKART_Human2.19540965
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.19540965
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02101979
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01653452
16UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.93117634
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91441753
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91441753
19STAT3_23295773_ChIP-Seq_U87_Human1.89827315
20P300_19829295_ChIP-Seq_ESCs_Human1.89353807
21SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.80370957
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77935748
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76812484
24SMAD4_21799915_ChIP-Seq_A2780_Human1.76782114
25AR_21572438_ChIP-Seq_LNCaP_Human1.75398104
26TAF15_26573619_Chip-Seq_HEK293_Human1.72517445
27AR_25329375_ChIP-Seq_VCAP_Human1.64480355
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.63047953
29SMAD4_21741376_ChIP-Seq_EPCs_Human1.61742327
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61296725
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57345213
32CDX2_22108803_ChIP-Seq_LS180_Human1.56462554
33MYC_19829295_ChIP-Seq_ESCs_Human1.53425680
34EZH2_22144423_ChIP-Seq_EOC_Human1.52561839
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.51903932
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48011809
37SOX2_19829295_ChIP-Seq_ESCs_Human1.44782022
38NANOG_19829295_ChIP-Seq_ESCs_Human1.44782022
39TCF4_23295773_ChIP-Seq_U87_Human1.43853446
40NFYB_21822215_ChIP-Seq_K562_Human1.43847245
41RUNX2_22187159_ChIP-Seq_PCA_Human1.42103442
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41665552
43TBL1_22424771_ChIP-Seq_293T_Human1.41405756
44NANOG_20526341_ChIP-Seq_ESCs_Human1.40544301
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39937085
46HNFA_21074721_ChIP-Seq_CACO-2_Human1.38870760
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.38820982
48HOXB7_26014856_ChIP-Seq_BT474_Human1.37363981
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36899526
50RBPJ_21746931_ChIP-Seq_IB4_Human1.34606131
51PHF8_20622853_ChIP-Seq_HELA_Human1.33868731
52TCF4_22108803_ChIP-Seq_LS180_Human1.32127224
53ETV1_20927104_ChIP-Seq_GIST48_Human1.31475018
54RAC3_21632823_ChIP-Seq_H3396_Human1.30124773
55CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29930635
56CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28386491
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28351052
58ERA_21632823_ChIP-Seq_H3396_Human1.28094766
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.27828798
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27057446
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27036027
62ERG_20517297_ChIP-Seq_VCAP_Human1.26525513
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25060946
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25020553
65TP53_22573176_ChIP-Seq_HFKS_Human1.24830253
66OCT4_20526341_ChIP-Seq_ESCs_Human1.22795189
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22594039
68TP53_18474530_ChIP-ChIP_U2OS_Human1.21377184
69CJUN_26792858_Chip-Seq_BT549_Human1.20931083
70EWS_26573619_Chip-Seq_HEK293_Human1.20874123
71NFYA_21822215_ChIP-Seq_K562_Human1.20445171
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.19847679
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.18988846
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18267817
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16996797
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.16530401
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.16490481
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.15397006
79AHR_22903824_ChIP-Seq_MCF-7_Human1.15385332
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15317450
81SMAD3_21741376_ChIP-Seq_ESCs_Human1.13397921
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12614601
83IRF1_19129219_ChIP-ChIP_H3396_Human1.12234374
84OCT1_27270436_Chip-Seq_PROSTATE_Human1.12085538
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11083502
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10239990
87BCAT_22108803_ChIP-Seq_LS180_Human1.09840065
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.08608780
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08241394
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07926752
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.07835473
92WDR5_24793694_ChIP-Seq_LNCAP_Human1.07478391
93CEBPB_22108803_ChIP-Seq_LS180_Human1.06022061
94GATA3_26560356_Chip-Seq_TH1_Human1.05429684
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02855165
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.02855165
97GATA1_22025678_ChIP-Seq_K562_Human1.02297387
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01185088
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00825162
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00746154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.98237168
2MP0009697_abnormal_copulation4.07118278
3MP0003698_abnormal_male_reproductive3.18308331
4MP0001929_abnormal_gametogenesis3.15047471
5MP0005670_abnormal_white_adipose2.79195814
6MP0005377_hearing/vestibular/ear_phenot2.70644638
7MP0003878_abnormal_ear_physiology2.70644638
8MP0000569_abnormal_digit_pigmentation2.66513628
9MP0003136_yellow_coat_color2.65419988
10MP0003787_abnormal_imprinting2.57498006
11MP0008004_abnormal_stomach_pH2.48055827
12MP0008877_abnormal_DNA_methylation2.26731984
13MP0005379_endocrine/exocrine_gland_phen2.24697633
14MP0001348_abnormal_lacrimal_gland2.12823115
15MP0005171_absent_coat_pigmentation1.90342807
16MP0005174_abnormal_tail_pigmentation1.87635293
17MP0002160_abnormal_reproductive_system1.87192344
18MP0000372_irregular_coat_pigmentation1.84999795
19MP0001984_abnormal_olfaction1.77480334
20MP0000015_abnormal_ear_pigmentation1.75415583
21MP0001485_abnormal_pinna_reflex1.75307201
22MP0005551_abnormal_eye_electrophysiolog1.72954121
23MP0005253_abnormal_eye_physiology1.69283403
24MP0002210_abnormal_sex_determination1.63091504
25MP0003646_muscle_fatigue1.61409741
26MP0003879_abnormal_hair_cell1.59972409
27MP0002161_abnormal_fertility/fecundity1.58188714
28MP0006072_abnormal_retinal_apoptosis1.57386471
29MP0001905_abnormal_dopamine_level1.54783961
30MP0001501_abnormal_sleep_pattern1.52482911
31MP0001968_abnormal_touch/_nociception1.51831416
32MP0003315_abnormal_perineum_morphology1.50433862
33MP0002138_abnormal_hepatobiliary_system1.44215396
34MP0002102_abnormal_ear_morphology1.43566421
35MP0005408_hypopigmentation1.42421996
36MP0000653_abnormal_sex_gland1.40818568
37MP0001145_abnormal_male_reproductive1.40681607
38MP0002095_abnormal_skin_pigmentation1.39935615
39MP0002837_dystrophic_cardiac_calcinosis1.38052360
40MP0000427_abnormal_hair_cycle1.31603029
41MP0002938_white_spotting1.30106357
42MP0001529_abnormal_vocalization1.27980318
43MP0003195_calcinosis1.21772322
44MP0002009_preneoplasia1.21451574
45MP0010386_abnormal_urinary_bladder1.21101862
46MP0005187_abnormal_penis_morphology1.16217799
47MP0005646_abnormal_pituitary_gland1.15967052
48MP0003718_maternal_effect1.14972601
49MP0000013_abnormal_adipose_tissue1.14213963
50MP0008058_abnormal_DNA_repair1.14131523
51MP0003045_fibrosis1.14119143
52MP0004084_abnormal_cardiac_muscle1.07525262
53MP0002876_abnormal_thyroid_physiology1.07168663
54MP0001963_abnormal_hearing_physiology1.06685477
55MP0004885_abnormal_endolymph1.03250114
56MP0005389_reproductive_system_phenotype1.02663797
57MP0001270_distended_abdomen0.99525435
58MP0005645_abnormal_hypothalamus_physiol0.98745355
59MP0005075_abnormal_melanosome_morpholog0.97808483
60MP0005248_abnormal_Harderian_gland0.97742441
61MP0005647_abnormal_sex_gland0.96799526
62MP0001486_abnormal_startle_reflex0.95209551
63MP0002557_abnormal_social/conspecific_i0.94946201
64MP0004742_abnormal_vestibular_system0.93498123
65MP0003950_abnormal_plasma_membrane0.92018938
66MP0001765_abnormal_ion_homeostasis0.90287878
67MP0002272_abnormal_nervous_system0.89394867
68MP0000371_diluted_coat_color0.86517512
69MP0010329_abnormal_lipoprotein_level0.84111468
70MP0005083_abnormal_biliary_tract0.81435892
71MP0002736_abnormal_nociception_after0.80786693
72MP0005360_urolithiasis0.79982112
73MP0008872_abnormal_physiological_respon0.79855035
74MP0003252_abnormal_bile_duct0.78489731
75MP0009745_abnormal_behavioral_response0.78337620
76MP0001664_abnormal_digestion0.78040449
77MP0001764_abnormal_homeostasis0.77597567
78MP0004924_abnormal_behavior0.77398911
79MP0005386_behavior/neurological_phenoty0.77398911
80MP0002067_abnormal_sensory_capabilities0.76813823
81MP0000026_abnormal_inner_ear0.75270383
82MP0010368_abnormal_lymphatic_system0.74480814
83MP0004381_abnormal_hair_follicle0.71812167
84MP0009046_muscle_twitch0.70130557
85MP0005310_abnormal_salivary_gland0.69737125
86MP0002229_neurodegeneration0.69434461
87MP0003936_abnormal_reproductive_system0.69314254
88MP0005391_vision/eye_phenotype0.68312115
89MP0005332_abnormal_amino_acid0.67582595
90MP0009780_abnormal_chondrocyte_physiolo0.64003018
91MP0008775_abnormal_heart_ventricle0.63704007
92MP0004036_abnormal_muscle_relaxation0.63644130
93MP0002132_abnormal_respiratory_system0.59510436
94MP0009115_abnormal_fat_cell0.57729583
95MP0002166_altered_tumor_susceptibility0.57352026
96MP0001502_abnormal_circadian_rhythm0.55924792
97MP0002572_abnormal_emotion/affect_behav0.53696387
98MP0003890_abnormal_embryonic-extraembry0.53020304
99MP0000538_abnormal_urinary_bladder0.52395177
100MP0000631_abnormal_neuroendocrine_gland0.52054685

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)5.69062214
2Chronic hepatic failure (HP:0100626)5.59997303
3Type II lissencephaly (HP:0007260)4.58776708
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.57276051
5Absent/shortened dynein arms (HP:0200106)4.57276051
6Tubulointerstitial nephritis (HP:0001970)4.37171698
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.34546513
8Hyperkalemia (HP:0002153)3.90766288
9Amelogenesis imperfecta (HP:0000705)3.68495729
10Abnormal respiratory motile cilium physiology (HP:0012261)3.63346999
11Abnormality of the renal cortex (HP:0011035)3.42134906
12Volvulus (HP:0002580)3.40789776
13Abnormal ciliary motility (HP:0012262)3.35802664
14Abnormality of dental color (HP:0011073)3.34671187
15Severe visual impairment (HP:0001141)3.15282760
16Infertility (HP:0000789)3.10322391
17Attenuation of retinal blood vessels (HP:0007843)3.07804154
18Abnormal respiratory epithelium morphology (HP:0012253)3.03072699
19Abnormal respiratory motile cilium morphology (HP:0005938)3.03072699
20Retinal dysplasia (HP:0007973)3.00512981
21Pancreatic cysts (HP:0001737)2.98864779
22Pancreatic fibrosis (HP:0100732)2.95943166
23Congenital sensorineural hearing impairment (HP:0008527)2.90040492
24Resting tremor (HP:0002322)2.83007926
25Retinal atrophy (HP:0001105)2.75126475
26Occipital encephalocele (HP:0002085)2.73205907
27Truncal obesity (HP:0001956)2.68405417
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.67874979
29Median cleft lip (HP:0000161)2.62922707
30Portal hypertension (HP:0001409)2.62411383
31Renovascular hypertension (HP:0100817)2.58199206
32Renal cortical cysts (HP:0000803)2.54694909
33Abnormal sex determination (HP:0012244)2.54074840
34Sex reversal (HP:0012245)2.54074840
35Bony spicule pigmentary retinopathy (HP:0007737)2.51089017
36Short tibia (HP:0005736)2.48686936
37Cone-rod dystrophy (HP:0000548)2.47863376
38Hypothermia (HP:0002045)2.47265580
39Abnormality of the hepatic vasculature (HP:0006707)2.46122847
40Increased circulating renin level (HP:0000848)2.45638384
41True hermaphroditism (HP:0010459)2.45588799
42Gonadal dysgenesis (HP:0000133)2.43096290
43Menstrual irregularities (HP:0000858)2.39243778
44Abnormality of the renal medulla (HP:0100957)2.36555728
45Postural instability (HP:0002172)2.36272039
46Nephronophthisis (HP:0000090)2.32249649
47Syringomyelia (HP:0003396)2.29335829
48Spinal cord lesions (HP:0100561)2.29335829
49Generalized aminoaciduria (HP:0002909)2.27987086
50Abnormal rod and cone electroretinograms (HP:0008323)2.20136506
51Rhinitis (HP:0012384)2.14918279
52Reduced antithrombin III activity (HP:0001976)2.14386215
53Potter facies (HP:0002009)2.13157136
54Facial shape deformation (HP:0011334)2.13157136
55White forelock (HP:0002211)2.12557591
56Tubulointerstitial abnormality (HP:0001969)2.09389777
57Tinnitus (HP:0000360)2.08064836
58Protruding tongue (HP:0010808)2.07788911
59Abnormality of macular pigmentation (HP:0008002)2.07420571
60Male pseudohermaphroditism (HP:0000037)2.04966893
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.04761122
62Hypoplasia of the fovea (HP:0007750)2.04761122
63Pancreatic islet-cell hyperplasia (HP:0004510)2.03209084
64Abnormal albumin level (HP:0012116)2.02265288
65Hypoalbuminemia (HP:0003073)2.02265288
66Hypoalphalipoproteinemia (HP:0003233)2.00072615
67Bell-shaped thorax (HP:0001591)1.98510934
68Chronic bronchitis (HP:0004469)1.98509826
69Polydipsia (HP:0001959)1.95934611
70Abnormal drinking behavior (HP:0030082)1.95934611
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.93106258
72Decreased central vision (HP:0007663)1.91601360
73Abnormality of the nasal septum (HP:0000419)1.90704374
74Gastrointestinal atresia (HP:0002589)1.90283878
75Cystic liver disease (HP:0006706)1.88416291
76Abnormality of midbrain morphology (HP:0002418)1.88341260
77Molar tooth sign on MRI (HP:0002419)1.88341260
78Febrile seizures (HP:0002373)1.86381316
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86038872
80Hypoplastic iliac wings (HP:0002866)1.84632791
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83237608
82J-shaped sella turcica (HP:0002680)1.82418400
83Abnormality of potassium homeostasis (HP:0011042)1.81834313
84Medial flaring of the eyebrow (HP:0010747)1.77071086
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76031916
86Absent epiphyses (HP:0010577)1.76031916
87Enlarged kidneys (HP:0000105)1.74846062
88Gaze-evoked nystagmus (HP:0000640)1.74637866
89Ectopic kidney (HP:0000086)1.74369059
90Progressive cerebellar ataxia (HP:0002073)1.73938379
91Midline defect of the nose (HP:0004122)1.73699225
92Intellectual disability, moderate (HP:0002342)1.73270714
93Insulin-resistant diabetes mellitus (HP:0000831)1.71850986
94Inability to walk (HP:0002540)1.71648128
95Poikilocytosis (HP:0004447)1.71511290
96Abnormality of lateral ventricle (HP:0030047)1.70984909
97Patchy hypopigmentation of hair (HP:0011365)1.70888209
98Optic nerve hypoplasia (HP:0000609)1.70043810
99Large for gestational age (HP:0001520)1.69730381
100Postaxial foot polydactyly (HP:0001830)1.66562444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.56813291
2PLK44.71670914
3MARK33.77284854
4FRK3.49295677
5STK38L3.22234441
6STK382.95170434
7BMPR1B2.81973357
8LATS12.74004388
9MAP3K22.56380257
10TLK12.22993248
11EIF2AK32.21032831
12ZAK2.13685123
13STK161.88435171
14PLK21.85078357
15BRD41.83389536
16CDK31.72124164
17BRSK21.53033415
18INSRR1.46339880
19NEK61.42428564
20TNIK1.41801362
21NTRK31.38311532
22PTK2B1.37059741
23MET1.36738417
24NUAK11.34846315
25PNCK1.32760425
26DDR21.32388766
27CAMK1G1.27409166
28STK31.25651146
29RPS6KA51.19392442
30MST1R1.18767567
31NEK21.18561575
32WNK41.14943434
33ADRBK21.12489262
34LATS21.10937920
35PIK3CG1.08003099
36EIF2AK20.99204426
37WEE10.97656241
38MAP3K90.96504688
39PRKD30.95904682
40SGK2230.88021490
41SGK4940.88021490
42PKN10.87871029
43SGK20.81340122
44MYLK0.80971574
45MAP2K70.80090825
46ERBB30.78305119
47EIF2AK10.71712343
48CSNK1A10.70488306
49CAMK1D0.70289562
50JAK10.70089987
51MAP3K40.67881198
52TIE10.67451732
53CSNK1A1L0.67212315
54PDPK10.66019093
55PDK10.64393451
56FGFR30.60218344
57AKT30.57629803
58MAP2K60.57072059
59PIM20.56448761
60CDK90.55975438
61PRKG10.55353264
62PIK3CA0.53515123
63SGK10.51939578
64STK390.51333900
65MAPK150.51087181
66CSNK1G10.48183409
67CHEK20.47881588
68CSNK1G30.46131017
69DAPK20.45709320
70ATM0.45494984
71TAOK30.45218383
72WNK10.45088894
73GRK10.44356508
74OBSCN0.43515556
75NLK0.42916546
76PRKCQ0.42668416
77WNK30.42520707
78MELK0.42401537
79PRKCE0.40067033
80DYRK30.39231904
81CAMKK20.37751175
82CSNK1D0.36997343
83YES10.36183847
84ARAF0.36152859
85PRKCH0.32960727
86KIT0.32827934
87TESK10.32603062
88CDK70.32177277
89CASK0.31816785
90MAPK10.31413650
91CSNK1G20.30195663
92GRK60.29269137
93MAP4K20.28716865
94BRSK10.28196459
95GSK3B0.27647346
96PRKAA20.25891027
97DYRK1B0.25781054
98PRKAA10.25334689
99MAPKAPK50.24884273
100RET0.24803245

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.84244268
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.72992166
3Nitrogen metabolism_Homo sapiens_hsa009102.93908126
4Butanoate metabolism_Homo sapiens_hsa006502.90620873
5Olfactory transduction_Homo sapiens_hsa047402.76343439
6Selenocompound metabolism_Homo sapiens_hsa004502.30963380
7One carbon pool by folate_Homo sapiens_hsa006702.20855095
8Basal transcription factors_Homo sapiens_hsa030222.13211359
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.08963278
10Dorso-ventral axis formation_Homo sapiens_hsa043202.05692834
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82899710
12Phototransduction_Homo sapiens_hsa047441.75384722
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70180901
14Fanconi anemia pathway_Homo sapiens_hsa034601.69771171
15Taste transduction_Homo sapiens_hsa047421.61881719
16Gap junction_Homo sapiens_hsa045401.55382823
17Homologous recombination_Homo sapiens_hsa034401.50369495
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44748344
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43399225
20ABC transporters_Homo sapiens_hsa020101.41561018
21Hedgehog signaling pathway_Homo sapiens_hsa043401.37001174
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.29166556
23RNA transport_Homo sapiens_hsa030131.26827371
24Circadian rhythm_Homo sapiens_hsa047101.23714121
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22614027
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19645008
27Herpes simplex infection_Homo sapiens_hsa051681.13793657
28Nicotine addiction_Homo sapiens_hsa050331.13755769
29Propanoate metabolism_Homo sapiens_hsa006401.13526953
30mRNA surveillance pathway_Homo sapiens_hsa030151.10133286
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08747306
32Linoleic acid metabolism_Homo sapiens_hsa005911.05538065
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.03865067
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02692460
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00821233
36Arginine biosynthesis_Homo sapiens_hsa002200.99297304
37Tryptophan metabolism_Homo sapiens_hsa003800.95568560
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94938549
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92954392
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90678328
41Type II diabetes mellitus_Homo sapiens_hsa049300.89855507
42Inositol phosphate metabolism_Homo sapiens_hsa005620.88089863
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87767129
44Fatty acid metabolism_Homo sapiens_hsa012120.87678723
45RNA degradation_Homo sapiens_hsa030180.87401965
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86394298
47Sphingolipid metabolism_Homo sapiens_hsa006000.86370931
48Oocyte meiosis_Homo sapiens_hsa041140.75465668
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.75256062
50Fatty acid degradation_Homo sapiens_hsa000710.72454105
51Chemical carcinogenesis_Homo sapiens_hsa052040.72041431
52Morphine addiction_Homo sapiens_hsa050320.70620031
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69612319
54Fat digestion and absorption_Homo sapiens_hsa049750.68880853
55Histidine metabolism_Homo sapiens_hsa003400.65415823
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63746160
57ECM-receptor interaction_Homo sapiens_hsa045120.63416695
58Phagosome_Homo sapiens_hsa041450.63318460
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61214680
60Renin secretion_Homo sapiens_hsa049240.60964297
61Small cell lung cancer_Homo sapiens_hsa052220.60255515
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59753849
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59614825
64Arachidonic acid metabolism_Homo sapiens_hsa005900.58798060
65Steroid biosynthesis_Homo sapiens_hsa001000.58518921
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57643750
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56831664
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56304828
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54465722
70Collecting duct acid secretion_Homo sapiens_hsa049660.52731680
71Influenza A_Homo sapiens_hsa051640.52099995
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52056712
73Measles_Homo sapiens_hsa051620.51724658
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50964172
75Retinol metabolism_Homo sapiens_hsa008300.50504328
76GABAergic synapse_Homo sapiens_hsa047270.47815041
77Calcium signaling pathway_Homo sapiens_hsa040200.46866027
78Tyrosine metabolism_Homo sapiens_hsa003500.46484561
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46033802
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44088222
81Purine metabolism_Homo sapiens_hsa002300.44076317
82beta-Alanine metabolism_Homo sapiens_hsa004100.43449496
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.43200259
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42554840
85Circadian entrainment_Homo sapiens_hsa047130.42376441
86Type I diabetes mellitus_Homo sapiens_hsa049400.42060859
87Pyrimidine metabolism_Homo sapiens_hsa002400.41862011
88Ether lipid metabolism_Homo sapiens_hsa005650.41567022
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41213319
90Graft-versus-host disease_Homo sapiens_hsa053320.40750752
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40250719
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.39471758
93Systemic lupus erythematosus_Homo sapiens_hsa053220.39186763
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38792886
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38212244
96Metabolic pathways_Homo sapiens_hsa011000.36196059
97Synaptic vesicle cycle_Homo sapiens_hsa047210.35915211
98PPAR signaling pathway_Homo sapiens_hsa033200.35842200
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.35324013
100Melanoma_Homo sapiens_hsa052180.34152207

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