ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.69100023
2	acrosome reaction (GO:0007340)	8.25909670
3	fusion of sperm to egg plasma membrane (GO:0007342)	7.21857772
4	spermatid development (GO:0007286)	6.86535165
5	protein polyglutamylation (GO:0018095)	6.60726972
6	multicellular organism reproduction (GO:0032504)	6.37785776
7	regulation of cilium movement (GO:0003352)	6.33136144
8	protein targeting to Golgi (GO:0000042)	6.23110762
9	establishment of protein localization to Golgi (GO:0072600)	6.22862497
10	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.81106075
11	sperm-egg recognition (GO:0035036)	5.55708765
12	plasma membrane fusion (GO:0045026)	5.53593316
13	protein localization to Golgi apparatus (GO:0034067)	5.50898828
14	spermatid nucleus differentiation (GO:0007289)	5.42417129
15	motile cilium assembly (GO:0044458)	5.34971300
16	binding of sperm to zona pellucida (GO:0007339)	5.13404135
17	rRNA methylation (GO:0031167)	5.09248578
18	epithelial cilium movement (GO:0003351)	5.08088319
19	cilium or flagellum-dependent cell motility (GO:0001539)	4.97532137
20	axonemal dynein complex assembly (GO:0070286)	4.96327522
21	chromosome condensation (GO:0030261)	4.93738833
22	reproduction (GO:0000003)	4.92377723
23	organic cation transport (GO:0015695)	4.92120502
24	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.88416565
25	male meiosis (GO:0007140)	4.75929280
26	single fertilization (GO:0007338)	4.74575045
27	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.71503079
28	cell-cell recognition (GO:0009988)	4.71213401
29	microtubule depolymerization (GO:0007019)	4.69961004
30	rRNA modification (GO:0000154)	4.63876516
31	phosphatidylethanolamine metabolic process (GO:0046337)	4.57498637
32	DNA packaging (GO:0006323)	4.52895675
33	calcium ion-dependent exocytosis (GO:0017156)	4.49246346
34	male gamete generation (GO:0048232)	4.42383995
35	spermatogenesis (GO:0007283)	4.41087906
36	centriole replication (GO:0007099)	4.41064213
37	centriole assembly (GO:0098534)	4.39007084
38	response to pheromone (GO:0019236)	4.38172920
39	regulation of microtubule-based movement (GO:0060632)	4.30639684
40	microtubule polymerization or depolymerization (GO:0031109)	4.27202401
41	sperm capacitation (GO:0048240)	4.26075933
42	cellular ketone body metabolic process (GO:0046950)	4.16773937
43	gamete generation (GO:0007276)	4.07515319
44	cilium movement (GO:0003341)	4.05804170
45	germ cell development (GO:0007281)	3.97008045
46	ketone body metabolic process (GO:1902224)	3.96144922
47	single strand break repair (GO:0000012)	3.94374827
48	axoneme assembly (GO:0035082)	3.84910241
49	fertilization (GO:0009566)	3.84383883
50	positive regulation of glycolytic process (GO:0045821)	3.66908006
51	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.57623765
52	seminiferous tubule development (GO:0072520)	3.49545119
53	regulation of centriole replication (GO:0046599)	3.41271346
54	acrosome assembly (GO:0001675)	3.40510232
55	piRNA metabolic process (GO:0034587)	3.29140833
56	multicellular organismal reproductive process (GO:0048609)	3.22232746
57	ventricular system development (GO:0021591)	3.18037355
58	negative regulation of inclusion body assembly (GO:0090084)	3.12630781
59	positive regulation of catecholamine secretion (GO:0033605)	3.11022455
60	DNA methylation involved in gamete generation (GO:0043046)	3.08088298
61	TOR signaling (GO:0031929)	3.06433729
62	centrosome duplication (GO:0051298)	3.05033418
63	synapsis (GO:0007129)	3.03264145
64	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.99987428
65	peptidyl-glutamic acid modification (GO:0018200)	2.98990356
66	intra-Golgi vesicle-mediated transport (GO:0006891)	2.97609962
67	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.94690524
68	protein targeting to vacuole (GO:0006623)	2.91979077
69	protein targeting to lysosome (GO:0006622)	2.91979077
70	establishment of protein localization to vacuole (GO:0072666)	2.91979077
71	cilium organization (GO:0044782)	2.89943761
72	positive regulation of Rab GTPase activity (GO:0032851)	2.89854347
73	regulation of Rab GTPase activity (GO:0032313)	2.89854347
74	cilium assembly (GO:0042384)	2.89186595
75	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.86568301
76	regulation of oxidative phosphorylation (GO:0002082)	2.85212866
77	coenzyme catabolic process (GO:0009109)	2.83670840
78	male sex determination (GO:0030238)	2.79039667
79	protein localization to cilium (GO:0061512)	2.78948623
80	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.78832496
81	dopamine transport (GO:0015872)	2.77866902
82	DNA double-strand break processing (GO:0000729)	2.76248790
83	regulation of meiosis I (GO:0060631)	2.73504326
84	microtubule severing (GO:0051013)	2.73182874
85	chromosome organization involved in meiosis (GO:0070192)	2.71904177
86	microtubule nucleation (GO:0007020)	2.71386927
87	genitalia morphogenesis (GO:0035112)	2.69531117
88	adaptation of signaling pathway (GO:0023058)	2.69002429
89	interleukin-6-mediated signaling pathway (GO:0070102)	2.66760559
90	nucleus organization (GO:0006997)	2.63515589
91	early endosome to late endosome transport (GO:0045022)	2.62365096
92	Golgi to endosome transport (GO:0006895)	2.60533187
93	protein-cofactor linkage (GO:0018065)	2.59284984
94	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.52189544
95	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.52189544
96	peristalsis (GO:0030432)	2.49770855
97	negative regulation of JUN kinase activity (GO:0043508)	2.49714153
98	meiotic nuclear division (GO:0007126)	2.49295780
99	regulation of growth hormone secretion (GO:0060123)	2.46306426
100	cellular zinc ion homeostasis (GO:0006882)	2.46006481

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.34458712
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.11729841
3	VDR_22108803_ChIP-Seq_LS180_Human	2.97403524
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.82865788
5	ER_23166858_ChIP-Seq_MCF-7_Human	2.81524807
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.75957544
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.62117022
8	FUS_26573619_Chip-Seq_HEK293_Human	2.59555430
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.40958010
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.33984873
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.27619918
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.19540965
13	CBP_20019798_ChIP-Seq_JUKART_Human	2.19540965
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.02101979
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01653452
16	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.93117634
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91441753
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.91441753
19	STAT3_23295773_ChIP-Seq_U87_Human	1.89827315
20	P300_19829295_ChIP-Seq_ESCs_Human	1.89353807
21	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.80370957
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77935748
23	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.76812484
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.76782114
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.75398104
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.72517445
27	AR_25329375_ChIP-Seq_VCAP_Human	1.64480355
28	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.63047953
29	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.61742327
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61296725
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57345213
32	CDX2_22108803_ChIP-Seq_LS180_Human	1.56462554
33	MYC_19829295_ChIP-Seq_ESCs_Human	1.53425680
34	EZH2_22144423_ChIP-Seq_EOC_Human	1.52561839
35	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.51903932
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48011809
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44782022
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44782022
39	TCF4_23295773_ChIP-Seq_U87_Human	1.43853446
40	NFYB_21822215_ChIP-Seq_K562_Human	1.43847245
41	RUNX2_22187159_ChIP-Seq_PCA_Human	1.42103442
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41665552
43	TBL1_22424771_ChIP-Seq_293T_Human	1.41405756
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.40544301
45	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.39937085
46	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.38870760
47	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.38820982
48	HOXB7_26014856_ChIP-Seq_BT474_Human	1.37363981
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36899526
50	RBPJ_21746931_ChIP-Seq_IB4_Human	1.34606131
51	PHF8_20622853_ChIP-Seq_HELA_Human	1.33868731
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.32127224
53	ETV1_20927104_ChIP-Seq_GIST48_Human	1.31475018
54	RAC3_21632823_ChIP-Seq_H3396_Human	1.30124773
55	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.29930635
56	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.28386491
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28351052
58	ERA_21632823_ChIP-Seq_H3396_Human	1.28094766
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27828798
60	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.27057446
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27036027
62	ERG_20517297_ChIP-Seq_VCAP_Human	1.26525513
63	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25060946
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25020553
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.24830253
66	OCT4_20526341_ChIP-Seq_ESCs_Human	1.22795189
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22594039
68	TP53_18474530_ChIP-ChIP_U2OS_Human	1.21377184
69	CJUN_26792858_Chip-Seq_BT549_Human	1.20931083
70	EWS_26573619_Chip-Seq_HEK293_Human	1.20874123
71	NFYA_21822215_ChIP-Seq_K562_Human	1.20445171
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19847679
73	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.18988846
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18267817
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16996797
76	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.16530401
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.16490481
78	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.15397006
79	AHR_22903824_ChIP-Seq_MCF-7_Human	1.15385332
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15317450
81	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.13397921
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12614601
83	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12234374
84	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.12085538
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11083502
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.10239990
87	BCAT_22108803_ChIP-Seq_LS180_Human	1.09840065
88	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.08608780
89	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08241394
90	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.07926752
91	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.07835473
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.07478391
93	CEBPB_22108803_ChIP-Seq_LS180_Human	1.06022061
94	GATA3_26560356_Chip-Seq_TH1_Human	1.05429684
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02855165
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02855165
97	GATA1_22025678_ChIP-Seq_K562_Human	1.02297387
98	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01185088
99	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.00825162
100	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.00746154

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.98237168
2	MP0009697_abnormal_copulation	4.07118278
3	MP0003698_abnormal_male_reproductive	3.18308331
4	MP0001929_abnormal_gametogenesis	3.15047471
5	MP0005670_abnormal_white_adipose	2.79195814
6	MP0005377_hearing/vestibular/ear_phenot	2.70644638
7	MP0003878_abnormal_ear_physiology	2.70644638
8	MP0000569_abnormal_digit_pigmentation	2.66513628
9	MP0003136_yellow_coat_color	2.65419988
10	MP0003787_abnormal_imprinting	2.57498006
11	MP0008004_abnormal_stomach_pH	2.48055827
12	MP0008877_abnormal_DNA_methylation	2.26731984
13	MP0005379_endocrine/exocrine_gland_phen	2.24697633
14	MP0001348_abnormal_lacrimal_gland	2.12823115
15	MP0005171_absent_coat_pigmentation	1.90342807
16	MP0005174_abnormal_tail_pigmentation	1.87635293
17	MP0002160_abnormal_reproductive_system	1.87192344
18	MP0000372_irregular_coat_pigmentation	1.84999795
19	MP0001984_abnormal_olfaction	1.77480334
20	MP0000015_abnormal_ear_pigmentation	1.75415583
21	MP0001485_abnormal_pinna_reflex	1.75307201
22	MP0005551_abnormal_eye_electrophysiolog	1.72954121
23	MP0005253_abnormal_eye_physiology	1.69283403
24	MP0002210_abnormal_sex_determination	1.63091504
25	MP0003646_muscle_fatigue	1.61409741
26	MP0003879_abnormal_hair_cell	1.59972409
27	MP0002161_abnormal_fertility/fecundity	1.58188714
28	MP0006072_abnormal_retinal_apoptosis	1.57386471
29	MP0001905_abnormal_dopamine_level	1.54783961
30	MP0001501_abnormal_sleep_pattern	1.52482911
31	MP0001968_abnormal_touch/_nociception	1.51831416
32	MP0003315_abnormal_perineum_morphology	1.50433862
33	MP0002138_abnormal_hepatobiliary_system	1.44215396
34	MP0002102_abnormal_ear_morphology	1.43566421
35	MP0005408_hypopigmentation	1.42421996
36	MP0000653_abnormal_sex_gland	1.40818568
37	MP0001145_abnormal_male_reproductive	1.40681607
38	MP0002095_abnormal_skin_pigmentation	1.39935615
39	MP0002837_dystrophic_cardiac_calcinosis	1.38052360
40	MP0000427_abnormal_hair_cycle	1.31603029
41	MP0002938_white_spotting	1.30106357
42	MP0001529_abnormal_vocalization	1.27980318
43	MP0003195_calcinosis	1.21772322
44	MP0002009_preneoplasia	1.21451574
45	MP0010386_abnormal_urinary_bladder	1.21101862
46	MP0005187_abnormal_penis_morphology	1.16217799
47	MP0005646_abnormal_pituitary_gland	1.15967052
48	MP0003718_maternal_effect	1.14972601
49	MP0000013_abnormal_adipose_tissue	1.14213963
50	MP0008058_abnormal_DNA_repair	1.14131523
51	MP0003045_fibrosis	1.14119143
52	MP0004084_abnormal_cardiac_muscle	1.07525262
53	MP0002876_abnormal_thyroid_physiology	1.07168663
54	MP0001963_abnormal_hearing_physiology	1.06685477
55	MP0004885_abnormal_endolymph	1.03250114
56	MP0005389_reproductive_system_phenotype	1.02663797
57	MP0001270_distended_abdomen	0.99525435
58	MP0005645_abnormal_hypothalamus_physiol	0.98745355
59	MP0005075_abnormal_melanosome_morpholog	0.97808483
60	MP0005248_abnormal_Harderian_gland	0.97742441
61	MP0005647_abnormal_sex_gland	0.96799526
62	MP0001486_abnormal_startle_reflex	0.95209551
63	MP0002557_abnormal_social/conspecific_i	0.94946201
64	MP0004742_abnormal_vestibular_system	0.93498123
65	MP0003950_abnormal_plasma_membrane	0.92018938
66	MP0001765_abnormal_ion_homeostasis	0.90287878
67	MP0002272_abnormal_nervous_system	0.89394867
68	MP0000371_diluted_coat_color	0.86517512
69	MP0010329_abnormal_lipoprotein_level	0.84111468
70	MP0005083_abnormal_biliary_tract	0.81435892
71	MP0002736_abnormal_nociception_after	0.80786693
72	MP0005360_urolithiasis	0.79982112
73	MP0008872_abnormal_physiological_respon	0.79855035
74	MP0003252_abnormal_bile_duct	0.78489731
75	MP0009745_abnormal_behavioral_response	0.78337620
76	MP0001664_abnormal_digestion	0.78040449
77	MP0001764_abnormal_homeostasis	0.77597567
78	MP0004924_abnormal_behavior	0.77398911
79	MP0005386_behavior/neurological_phenoty	0.77398911
80	MP0002067_abnormal_sensory_capabilities	0.76813823
81	MP0000026_abnormal_inner_ear	0.75270383
82	MP0010368_abnormal_lymphatic_system	0.74480814
83	MP0004381_abnormal_hair_follicle	0.71812167
84	MP0009046_muscle_twitch	0.70130557
85	MP0005310_abnormal_salivary_gland	0.69737125
86	MP0002229_neurodegeneration	0.69434461
87	MP0003936_abnormal_reproductive_system	0.69314254
88	MP0005391_vision/eye_phenotype	0.68312115
89	MP0005332_abnormal_amino_acid	0.67582595
90	MP0009780_abnormal_chondrocyte_physiolo	0.64003018
91	MP0008775_abnormal_heart_ventricle	0.63704007
92	MP0004036_abnormal_muscle_relaxation	0.63644130
93	MP0002132_abnormal_respiratory_system	0.59510436
94	MP0009115_abnormal_fat_cell	0.57729583
95	MP0002166_altered_tumor_susceptibility	0.57352026
96	MP0001502_abnormal_circadian_rhythm	0.55924792
97	MP0002572_abnormal_emotion/affect_behav	0.53696387
98	MP0003890_abnormal_embryonic-extraembry	0.53020304
99	MP0000538_abnormal_urinary_bladder	0.52395177
100	MP0000631_abnormal_neuroendocrine_gland	0.52054685

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cerebellar dysplasia (HP:0007033)	5.69062214
2	Chronic hepatic failure (HP:0100626)	5.59997303
3	Type II lissencephaly (HP:0007260)	4.58776708
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.57276051
5	Absent/shortened dynein arms (HP:0200106)	4.57276051
6	Tubulointerstitial nephritis (HP:0001970)	4.37171698
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.34546513
8	Hyperkalemia (HP:0002153)	3.90766288
9	Amelogenesis imperfecta (HP:0000705)	3.68495729
10	Abnormal respiratory motile cilium physiology (HP:0012261)	3.63346999
11	Abnormality of the renal cortex (HP:0011035)	3.42134906
12	Volvulus (HP:0002580)	3.40789776
13	Abnormal ciliary motility (HP:0012262)	3.35802664
14	Abnormality of dental color (HP:0011073)	3.34671187
15	Severe visual impairment (HP:0001141)	3.15282760
16	Infertility (HP:0000789)	3.10322391
17	Attenuation of retinal blood vessels (HP:0007843)	3.07804154
18	Abnormal respiratory epithelium morphology (HP:0012253)	3.03072699
19	Abnormal respiratory motile cilium morphology (HP:0005938)	3.03072699
20	Retinal dysplasia (HP:0007973)	3.00512981
21	Pancreatic cysts (HP:0001737)	2.98864779
22	Pancreatic fibrosis (HP:0100732)	2.95943166
23	Congenital sensorineural hearing impairment (HP:0008527)	2.90040492
24	Resting tremor (HP:0002322)	2.83007926
25	Retinal atrophy (HP:0001105)	2.75126475
26	Occipital encephalocele (HP:0002085)	2.73205907
27	Truncal obesity (HP:0001956)	2.68405417
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.67874979
29	Median cleft lip (HP:0000161)	2.62922707
30	Portal hypertension (HP:0001409)	2.62411383
31	Renovascular hypertension (HP:0100817)	2.58199206
32	Renal cortical cysts (HP:0000803)	2.54694909
33	Abnormal sex determination (HP:0012244)	2.54074840
34	Sex reversal (HP:0012245)	2.54074840
35	Bony spicule pigmentary retinopathy (HP:0007737)	2.51089017
36	Short tibia (HP:0005736)	2.48686936
37	Cone-rod dystrophy (HP:0000548)	2.47863376
38	Hypothermia (HP:0002045)	2.47265580
39	Abnormality of the hepatic vasculature (HP:0006707)	2.46122847
40	Increased circulating renin level (HP:0000848)	2.45638384
41	True hermaphroditism (HP:0010459)	2.45588799
42	Gonadal dysgenesis (HP:0000133)	2.43096290
43	Menstrual irregularities (HP:0000858)	2.39243778
44	Abnormality of the renal medulla (HP:0100957)	2.36555728
45	Postural instability (HP:0002172)	2.36272039
46	Nephronophthisis (HP:0000090)	2.32249649
47	Syringomyelia (HP:0003396)	2.29335829
48	Spinal cord lesions (HP:0100561)	2.29335829
49	Generalized aminoaciduria (HP:0002909)	2.27987086
50	Abnormal rod and cone electroretinograms (HP:0008323)	2.20136506
51	Rhinitis (HP:0012384)	2.14918279
52	Reduced antithrombin III activity (HP:0001976)	2.14386215
53	Potter facies (HP:0002009)	2.13157136
54	Facial shape deformation (HP:0011334)	2.13157136
55	White forelock (HP:0002211)	2.12557591
56	Tubulointerstitial abnormality (HP:0001969)	2.09389777
57	Tinnitus (HP:0000360)	2.08064836
58	Protruding tongue (HP:0010808)	2.07788911
59	Abnormality of macular pigmentation (HP:0008002)	2.07420571
60	Male pseudohermaphroditism (HP:0000037)	2.04966893
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.04761122
62	Hypoplasia of the fovea (HP:0007750)	2.04761122
63	Pancreatic islet-cell hyperplasia (HP:0004510)	2.03209084
64	Abnormal albumin level (HP:0012116)	2.02265288
65	Hypoalbuminemia (HP:0003073)	2.02265288
66	Hypoalphalipoproteinemia (HP:0003233)	2.00072615
67	Bell-shaped thorax (HP:0001591)	1.98510934
68	Chronic bronchitis (HP:0004469)	1.98509826
69	Polydipsia (HP:0001959)	1.95934611
70	Abnormal drinking behavior (HP:0030082)	1.95934611
71	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.93106258
72	Decreased central vision (HP:0007663)	1.91601360
73	Abnormality of the nasal septum (HP:0000419)	1.90704374
74	Gastrointestinal atresia (HP:0002589)	1.90283878
75	Cystic liver disease (HP:0006706)	1.88416291
76	Abnormality of midbrain morphology (HP:0002418)	1.88341260
77	Molar tooth sign on MRI (HP:0002419)	1.88341260
78	Febrile seizures (HP:0002373)	1.86381316
79	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.86038872
80	Hypoplastic iliac wings (HP:0002866)	1.84632791
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.83237608
82	J-shaped sella turcica (HP:0002680)	1.82418400
83	Abnormality of potassium homeostasis (HP:0011042)	1.81834313
84	Medial flaring of the eyebrow (HP:0010747)	1.77071086
85	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.76031916
86	Absent epiphyses (HP:0010577)	1.76031916
87	Enlarged kidneys (HP:0000105)	1.74846062
88	Gaze-evoked nystagmus (HP:0000640)	1.74637866
89	Ectopic kidney (HP:0000086)	1.74369059
90	Progressive cerebellar ataxia (HP:0002073)	1.73938379
91	Midline defect of the nose (HP:0004122)	1.73699225
92	Intellectual disability, moderate (HP:0002342)	1.73270714
93	Insulin-resistant diabetes mellitus (HP:0000831)	1.71850986
94	Inability to walk (HP:0002540)	1.71648128
95	Poikilocytosis (HP:0004447)	1.71511290
96	Abnormality of lateral ventricle (HP:0030047)	1.70984909
97	Patchy hypopigmentation of hair (HP:0011365)	1.70888209
98	Optic nerve hypoplasia (HP:0000609)	1.70043810
99	Large for gestational age (HP:0001520)	1.69730381
100	Postaxial foot polydactyly (HP:0001830)	1.66562444

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.56813291
2	PLK4	4.71670914
3	MARK3	3.77284854
4	FRK	3.49295677
5	STK38L	3.22234441
6	STK38	2.95170434
7	BMPR1B	2.81973357
8	LATS1	2.74004388
9	MAP3K2	2.56380257
10	TLK1	2.22993248
11	EIF2AK3	2.21032831
12	ZAK	2.13685123
13	STK16	1.88435171
14	PLK2	1.85078357
15	BRD4	1.83389536
16	CDK3	1.72124164
17	BRSK2	1.53033415
18	INSRR	1.46339880
19	NEK6	1.42428564
20	TNIK	1.41801362
21	NTRK3	1.38311532
22	PTK2B	1.37059741
23	MET	1.36738417
24	NUAK1	1.34846315
25	PNCK	1.32760425
26	DDR2	1.32388766
27	CAMK1G	1.27409166
28	STK3	1.25651146
29	RPS6KA5	1.19392442
30	MST1R	1.18767567
31	NEK2	1.18561575
32	WNK4	1.14943434
33	ADRBK2	1.12489262
34	LATS2	1.10937920
35	PIK3CG	1.08003099
36	EIF2AK2	0.99204426
37	WEE1	0.97656241
38	MAP3K9	0.96504688
39	PRKD3	0.95904682
40	SGK223	0.88021490
41	SGK494	0.88021490
42	PKN1	0.87871029
43	SGK2	0.81340122
44	MYLK	0.80971574
45	MAP2K7	0.80090825
46	ERBB3	0.78305119
47	EIF2AK1	0.71712343
48	CSNK1A1	0.70488306
49	CAMK1D	0.70289562
50	JAK1	0.70089987
51	MAP3K4	0.67881198
52	TIE1	0.67451732
53	CSNK1A1L	0.67212315
54	PDPK1	0.66019093
55	PDK1	0.64393451
56	FGFR3	0.60218344
57	AKT3	0.57629803
58	MAP2K6	0.57072059
59	PIM2	0.56448761
60	CDK9	0.55975438
61	PRKG1	0.55353264
62	PIK3CA	0.53515123
63	SGK1	0.51939578
64	STK39	0.51333900
65	MAPK15	0.51087181
66	CSNK1G1	0.48183409
67	CHEK2	0.47881588
68	CSNK1G3	0.46131017
69	DAPK2	0.45709320
70	ATM	0.45494984
71	TAOK3	0.45218383
72	WNK1	0.45088894
73	GRK1	0.44356508
74	OBSCN	0.43515556
75	NLK	0.42916546
76	PRKCQ	0.42668416
77	WNK3	0.42520707
78	MELK	0.42401537
79	PRKCE	0.40067033
80	DYRK3	0.39231904
81	CAMKK2	0.37751175
82	CSNK1D	0.36997343
83	YES1	0.36183847
84	ARAF	0.36152859
85	PRKCH	0.32960727
86	KIT	0.32827934
87	TESK1	0.32603062
88	CDK7	0.32177277
89	CASK	0.31816785
90	MAPK1	0.31413650
91	CSNK1G2	0.30195663
92	GRK6	0.29269137
93	MAP4K2	0.28716865
94	BRSK1	0.28196459
95	GSK3B	0.27647346
96	PRKAA2	0.25891027
97	DYRK1B	0.25781054
98	PRKAA1	0.25334689
99	MAPKAPK5	0.24884273
100	RET	0.24803245

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.84244268
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.72992166
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.93908126
4	Butanoate metabolism_Homo sapiens_hsa00650	2.90620873
5	Olfactory transduction_Homo sapiens_hsa04740	2.76343439
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.30963380
7	One carbon pool by folate_Homo sapiens_hsa00670	2.20855095
8	Basal transcription factors_Homo sapiens_hsa03022	2.13211359
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.08963278
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.05692834
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.82899710
12	Phototransduction_Homo sapiens_hsa04744	1.75384722
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.70180901
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69771171
15	Taste transduction_Homo sapiens_hsa04742	1.61881719
16	Gap junction_Homo sapiens_hsa04540	1.55382823
17	Homologous recombination_Homo sapiens_hsa03440	1.50369495
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.44748344
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.43399225
20	ABC transporters_Homo sapiens_hsa02010	1.41561018
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.37001174
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.29166556
23	RNA transport_Homo sapiens_hsa03013	1.26827371
24	Circadian rhythm_Homo sapiens_hsa04710	1.23714121
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.22614027
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.19645008
27	Herpes simplex infection_Homo sapiens_hsa05168	1.13793657
28	Nicotine addiction_Homo sapiens_hsa05033	1.13755769
29	Propanoate metabolism_Homo sapiens_hsa00640	1.13526953
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.10133286
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08747306
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.05538065
33	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.03865067
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02692460
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00821233
36	Arginine biosynthesis_Homo sapiens_hsa00220	0.99297304
37	Tryptophan metabolism_Homo sapiens_hsa00380	0.95568560
38	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.94938549
39	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.92954392
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90678328
41	Type II diabetes mellitus_Homo sapiens_hsa04930	0.89855507
42	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.88089863
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87767129
44	Fatty acid metabolism_Homo sapiens_hsa01212	0.87678723
45	RNA degradation_Homo sapiens_hsa03018	0.87401965
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.86394298
47	Sphingolipid metabolism_Homo sapiens_hsa00600	0.86370931
48	Oocyte meiosis_Homo sapiens_hsa04114	0.75465668
49	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.75256062
50	Fatty acid degradation_Homo sapiens_hsa00071	0.72454105
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72041431
52	Morphine addiction_Homo sapiens_hsa05032	0.70620031
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.69612319
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.68880853
55	Histidine metabolism_Homo sapiens_hsa00340	0.65415823
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.63746160
57	ECM-receptor interaction_Homo sapiens_hsa04512	0.63416695
58	Phagosome_Homo sapiens_hsa04145	0.63318460
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61214680
60	Renin secretion_Homo sapiens_hsa04924	0.60964297
61	Small cell lung cancer_Homo sapiens_hsa05222	0.60255515
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.59753849
63	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.59614825
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58798060
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.58518921
66	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57643750
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56831664
68	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56304828
69	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.54465722
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52731680
71	Influenza A_Homo sapiens_hsa05164	0.52099995
72	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.52056712
73	Measles_Homo sapiens_hsa05162	0.51724658
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50964172
75	Retinol metabolism_Homo sapiens_hsa00830	0.50504328
76	GABAergic synapse_Homo sapiens_hsa04727	0.47815041
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.46866027
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.46484561
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.46033802
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.44088222
81	Purine metabolism_Homo sapiens_hsa00230	0.44076317
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43449496
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43200259
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.42554840
85	Circadian entrainment_Homo sapiens_hsa04713	0.42376441
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42060859
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41862011
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.41567022
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41213319
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.40750752
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40250719
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39471758
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.39186763
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38792886
95	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.38212244
96	Metabolic pathways_Homo sapiens_hsa01100	0.36196059
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35915211
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.35842200
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.35324013
100	Melanoma_Homo sapiens_hsa05218	0.34152207

ANKRD20A9P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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