ANKRD23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.99984079
2actin-mediated cell contraction (GO:0070252)8.93881513
3sarcomere organization (GO:0045214)8.81393536
4skeletal muscle contraction (GO:0003009)8.36953581
5sarcoplasmic reticulum calcium ion transport (GO:0070296)8.35825678
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.52772675
7plasma membrane repair (GO:0001778)7.51203353
8myofibril assembly (GO:0030239)7.50289606
9skeletal muscle adaptation (GO:0043501)6.94993144
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.68106614
11actin filament-based movement (GO:0030048)6.64285518
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.61496648
13striated muscle contraction (GO:0006941)6.58725202
14cardiac myofibril assembly (GO:0055003)6.47978684
15response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.15525648
16regulation of cell communication by electrical coupling (GO:0010649)5.88522747
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.85858072
18carnitine shuttle (GO:0006853)5.82707671
19cardiac muscle contraction (GO:0060048)5.76645717
20creatine metabolic process (GO:0006600)5.73838934
21actomyosin structure organization (GO:0031032)5.73352709
22negative regulation of potassium ion transmembrane transport (GO:1901380)5.67787062
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.49015997
24regulation of relaxation of muscle (GO:1901077)5.48732234
25tricarboxylic acid cycle (GO:0006099)5.35368828
26regulation of actin filament-based movement (GO:1903115)5.23502852
27response to inactivity (GO:0014854)5.09001723
28muscle contraction (GO:0006936)5.00447195
29cardiac muscle cell development (GO:0055013)4.98624091
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.98557168
31regulation of acyl-CoA biosynthetic process (GO:0050812)4.97064517
32fatty acid transmembrane transport (GO:1902001)4.93952236
33skeletal muscle fiber development (GO:0048741)4.92302966
34glycogen catabolic process (GO:0005980)4.85129753
35skeletal muscle tissue development (GO:0007519)4.83615789
36striated muscle atrophy (GO:0014891)4.69658070
37cardiac cell development (GO:0055006)4.67144598
38striated muscle adaptation (GO:0014888)4.65661512
39skeletal muscle tissue regeneration (GO:0043403)4.65628043
40regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.65247258
41response to muscle activity (GO:0014850)4.64600915
42heart process (GO:0003015)4.58885926
43heart contraction (GO:0060047)4.58885926
44regulation of striated muscle contraction (GO:0006942)4.56161807
45muscle system process (GO:0003012)4.55564592
46glucan catabolic process (GO:0009251)4.52078240
47regulation of coenzyme metabolic process (GO:0051196)4.46246561
48regulation of cofactor metabolic process (GO:0051193)4.46246561
49fructose metabolic process (GO:0006000)4.42245176
50pyrimidine ribonucleoside catabolic process (GO:0046133)4.41393338
51carnitine transmembrane transport (GO:1902603)4.31741566
52cardiac muscle hypertrophy (GO:0003300)4.31113524
53striated muscle hypertrophy (GO:0014897)4.30739079
54cardiac muscle tissue morphogenesis (GO:0055008)4.30629998
55muscle fiber development (GO:0048747)4.27357967
56muscle organ morphogenesis (GO:0048644)4.26563811
57myotube cell development (GO:0014904)4.26540937
58cellular polysaccharide catabolic process (GO:0044247)4.23537221
59muscle tissue morphogenesis (GO:0060415)4.16047137
60adult heart development (GO:0007512)4.14591183
61muscle atrophy (GO:0014889)4.10028087
62regulation of sarcomere organization (GO:0060297)4.09391447
63regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.08968055
64cytidine deamination (GO:0009972)4.08234342
65cytidine metabolic process (GO:0046087)4.08234342
66cytidine catabolic process (GO:0006216)4.08234342
67glycogen biosynthetic process (GO:0005978)4.06795419
68glucan biosynthetic process (GO:0009250)4.06795419
69gluconeogenesis (GO:0006094)4.03708092
70response to activity (GO:0014823)4.02710825
71muscle cell fate commitment (GO:0042693)4.01012363
72striated muscle cell development (GO:0055002)4.00910478
73polysaccharide catabolic process (GO:0000272)4.00750709
74positive regulation of myotube differentiation (GO:0010831)3.94855853
75regulation of membrane repolarization (GO:0060306)3.94117487
76muscle structure development (GO:0061061)3.93824339
77amino-acid betaine transport (GO:0015838)3.90905527
78carnitine transport (GO:0015879)3.90905527
79muscle adaptation (GO:0043500)3.89331162
80ventricular cardiac muscle cell action potential (GO:0086005)3.87710699
81positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.87168382
82muscle hypertrophy (GO:0014896)3.80666570
83negative regulation of muscle hypertrophy (GO:0014741)3.73822649
84neuronal action potential propagation (GO:0019227)3.69880272
85positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.69804737
86regulation of sulfur metabolic process (GO:0042762)3.66026507
87ubiquinone biosynthetic process (GO:0006744)3.63709154
88regulation of calcium ion transmembrane transporter activity (GO:1901019)3.63000652
89regulation of calcium ion transmembrane transport (GO:1903169)3.63000652
90myoblast fusion (GO:0007520)3.62153560
91IMP metabolic process (GO:0046040)3.61927361
92hexose biosynthetic process (GO:0019319)3.60607810
93heart trabecula formation (GO:0060347)3.58200551
94negative regulation of calcium ion transmembrane transport (GO:1903170)3.57439015
95negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.57439015
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57259227
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.57193112
98regulation of sequestering of triglyceride (GO:0010889)3.55412692
99negative regulation of muscle contraction (GO:0045932)3.53369384
100NADH metabolic process (GO:0006734)3.51038945
101purine nucleotide salvage (GO:0032261)3.47867165
102muscle cell cellular homeostasis (GO:0046716)3.47784422
1032-oxoglutarate metabolic process (GO:0006103)3.45452326
104glycogen metabolic process (GO:0005977)3.45102922
105cellular carbohydrate catabolic process (GO:0044275)3.45089905
106negative regulation of protein localization to cell surface (GO:2000009)3.45026824
107muscle cell development (GO:0055001)3.42045714
108positive regulation of cation channel activity (GO:2001259)3.41689921
109oxidative phosphorylation (GO:0006119)3.39710772
110myotube differentiation (GO:0014902)3.38391863
111cellular glucan metabolic process (GO:0006073)3.37569906
112glucan metabolic process (GO:0044042)3.37569906
113regulation of skeletal muscle cell differentiation (GO:2001014)3.35614177
114cardiac muscle adaptation (GO:0014887)3.34825068
115cardiac muscle hypertrophy in response to stress (GO:0014898)3.34825068
116muscle hypertrophy in response to stress (GO:0003299)3.34825068
117ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.32656226
118neuromuscular synaptic transmission (GO:0007274)3.31347552
119muscle organ development (GO:0007517)3.30760462
120respiratory electron transport chain (GO:0022904)3.29809582
121succinate metabolic process (GO:0006105)3.27602057
122regulation of myoblast differentiation (GO:0045661)3.27262567
123striated muscle tissue development (GO:0014706)3.27077792
124ubiquinone metabolic process (GO:0006743)3.22395004
125relaxation of muscle (GO:0090075)3.20640745
126actin-myosin filament sliding (GO:0033275)10.8831926
127muscle filament sliding (GO:0030049)10.8831926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.56390135
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.86528117
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.90850625
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.80761095
5* TBX20_22328084_ChIP-Seq_HEART_Mouse3.67738333
6* TBX20_22080862_ChIP-Seq_HEART_Mouse3.67738333
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.62723199
8EP300_21415370_ChIP-Seq_HL-1_Mouse3.52460567
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.71241120
10* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.68628746
11ZNF263_19887448_ChIP-Seq_K562_Human2.68003487
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43102395
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38058278
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.33662957
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28032730
16GATA4_21415370_ChIP-Seq_HL-1_Mouse2.17460287
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15899586
18BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.14496008
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08295807
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99750478
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88194822
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76600792
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72532986
24NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.70421364
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63502289
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61490183
27PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.50212930
28CTCF_27219007_Chip-Seq_Bcells_Human1.48447809
29EZH2_22144423_ChIP-Seq_EOC_Human1.47166434
30CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.46641887
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46449658
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41427690
33IGF1R_20145208_ChIP-Seq_DFB_Human1.40211104
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39965182
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39337903
36CTCF_21964334_ChIP-Seq_BJAB-B_Human1.38178392
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.32987111
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.30537427
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29810272
40ZNF274_21170338_ChIP-Seq_K562_Hela1.28760421
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28721920
42CLOCK_20551151_ChIP-Seq_293T_Human1.27369693
43* ESR2_21235772_ChIP-Seq_MCF-7_Human1.25830166
44DROSHA_22980978_ChIP-Seq_HELA_Human1.24547070
45FOXH1_21741376_ChIP-Seq_ESCs_Human1.23495885
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22078470
47OCT4_20526341_ChIP-Seq_ESCs_Human1.22048189
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.21323938
49STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.17950441
50SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16660030
51KDM2B_26808549_Chip-Seq_DND41_Human1.15940259
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15726126
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.13282406
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13100948
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12040491
56AR_21572438_ChIP-Seq_LNCaP_Human1.10400989
57CTCF_21964334_Chip-Seq_Bcells_Human1.09059919
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08849769
59GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08222790
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.07644815
61GATA1_22025678_ChIP-Seq_K562_Human1.07078185
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06292100
63SPI1_20517297_ChIP-Seq_HL60_Human1.05798971
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.05714038
65SA1_27219007_Chip-Seq_Bcells_Human1.04387712
66P68_20966046_ChIP-Seq_HELA_Human1.04050258
67TP63_22573176_ChIP-Seq_HFKS_Human1.04037471
68* MYC_27129775_Chip-Seq_CORNEA_Mouse1.03603744
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02253773
70SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00444646
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00371323
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97659998
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96384911
74P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96025441
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95341778
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95238256
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94948110
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94186809
79BCL6_27268052_Chip-Seq_Bcells_Human0.93638757
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93452624
81CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93336300
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.92447100
83* CRX_20693478_ChIP-Seq_RETINA_Mouse0.92124999
84DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91916481
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91711221
86* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91454939
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.90754853
88LXR_22292898_ChIP-Seq_THP-1_Human0.90417491
89CJUN_26792858_Chip-Seq_BT549_Human0.89437357
90RACK7_27058665_Chip-Seq_MCF-7_Human0.89381035
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89099722
92NANOG_20526341_ChIP-Seq_ESCs_Human0.88956472
93E2F1_20622854_ChIP-Seq_HELA_Human0.85671888
94CTCF_26484167_Chip-Seq_Bcells_Mouse0.84881997
95STAT1_20625510_ChIP-Seq_HELA_Human0.84730716
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84207415
97ATF3_27146783_Chip-Seq_COLON_Human0.83933078
98GATA1_19941826_ChIP-Seq_K562_Human0.83434117
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83210242
100DPY_21335234_ChIP-Seq_ESCs_Mouse0.82758278
101GATA3_21867929_ChIP-Seq_CD8_Mouse0.82665227
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.82526161
103RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81678421
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81673146
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81530907
106GATA6_21074721_ChIP-Seq_CACO-2_Human0.81116417
107TCF7_22412390_ChIP-Seq_EML_Mouse0.80667718
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80448923
109* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80350600
110CEBPB_22108803_ChIP-Seq_LS180_Human0.80034743
111LXR_22158963_ChIP-Seq_LIVER_Mouse0.79118128
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78259230
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78174960
114PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77618812
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.77249961
116HTT_18923047_ChIP-ChIP_STHdh_Human0.77170462
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.76997461
118* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76918825
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76802491
120GATA2_19941826_ChIP-Seq_K562_Human0.76411607
121CSB_26484114_Chip-Seq_FIBROBLAST_Human0.76389002
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76225589
123RAC3_21632823_ChIP-Seq_H3396_Human0.75730808
124ELF1_20517297_ChIP-Seq_JURKAT_Human0.75249711
125P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.74885722
126* EZH2_27294783_Chip-Seq_NPCs_Mouse0.74395266
127CREB1_26743006_Chip-Seq_LNCaP_Human0.73884869
128CBP_21632823_ChIP-Seq_H3396_Human0.73868147
129SOX2_21211035_ChIP-Seq_LN229_Gbm0.73864138
130ER_23166858_ChIP-Seq_MCF-7_Human0.73464389
131* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73211533
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.73115657
133CBP_20019798_ChIP-Seq_JUKART_Human0.73115657
134* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72893840
135BCOR_27268052_Chip-Seq_Bcells_Human0.72657881
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.71436957
137P53_21459846_ChIP-Seq_SAOS-2_Human0.71283076
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.71067370
139LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.70527176
140CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70070480
141GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.68691938
142SOX2_22085726_ChIP-Seq_NPCs_Mouse0.68316180
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.67770424
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.66805436
145TP53_20018659_ChIP-ChIP_R1E_Mouse0.66785988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.70784722
2MP0000751_myopathy5.85110573
3MP0002837_dystrophic_cardiac_calcinosis5.70115769
4MP0000749_muscle_degeneration5.56802517
5MP0004145_abnormal_muscle_electrophysio5.43237390
6MP0004036_abnormal_muscle_relaxation4.36294532
7MP0004084_abnormal_cardiac_muscle3.86331093
8MP0002106_abnormal_muscle_physiology3.65083003
9MP0004087_abnormal_muscle_fiber3.48365074
10MP0000747_muscle_weakness3.44021431
11MP0004215_abnormal_myocardial_fiber3.29957045
12MP0000750_abnormal_muscle_regeneration3.24499560
13MP0000759_abnormal_skeletal_muscle3.13106252
14MP0005330_cardiomyopathy3.10511604
15MP0002269_muscular_atrophy3.10062773
16MP0005620_abnormal_muscle_contractility3.09870038
17MP0004130_abnormal_muscle_cell3.03992783
18MP0005369_muscle_phenotype3.03783648
19MP0002972_abnormal_cardiac_muscle2.34837683
20MP0004233_abnormal_muscle_weight2.16874103
21MP0004484_altered_response_of2.02484735
22MP0010630_abnormal_cardiac_muscle2.02150071
23MP0006036_abnormal_mitochondrial_physio1.96803732
24MP0003137_abnormal_impulse_conducting1.91952881
25MP0002332_abnormal_exercise_endurance1.88976175
26MP0005385_cardiovascular_system_phenoty1.86130926
27MP0001544_abnormal_cardiovascular_syste1.86130926
28MP0008775_abnormal_heart_ventricle1.82087384
29MP0000733_abnormal_muscle_development1.68032347
30MP0003221_abnormal_cardiomyocyte_apopto1.66046904
31MP0002108_abnormal_muscle_morphology1.65800444
32MP0005666_abnormal_adipose_tissue1.49746710
33MP0006138_congestive_heart_failure1.44604269
34MP0003950_abnormal_plasma_membrane1.39724778
35MP0004185_abnormal_adipocyte_glucose1.34823053
36MP0003828_pulmonary_edema1.32958917
37MP0004085_abnormal_heartbeat1.23319730
38MP0004510_myositis1.20089493
39MP0002127_abnormal_cardiovascular_syste1.13643155
40MP0005375_adipose_tissue_phenotype1.11950416
41MP0005670_abnormal_white_adipose1.11517396
42MP0006035_abnormal_mitochondrial_morpho1.08972332
43MP0000013_abnormal_adipose_tissue1.07800998
44MP0001661_extended_life_span1.06744474
45MP0002971_abnormal_brown_adipose1.02441585
46MP0000343_altered_response_to1.00153237
47MP0005266_abnormal_metabolism0.99401047
48MP0002234_abnormal_pharynx_morphology0.91878715
49MP0003806_abnormal_nucleotide_metabolis0.91018809
50MP0009780_abnormal_chondrocyte_physiolo0.89999716
51MP0000266_abnormal_heart_morphology0.87611789
52MP0004147_increased_porphyrin_level0.83645363
53MP0000003_abnormal_adipose_tissue0.71807654
54MP0003567_abnormal_fetal_cardiomyocyte0.69399018
55MP0004043_abnormal_pH_regulation0.64465093
56MP0003879_abnormal_hair_cell0.63482505
57MP0005165_increased_susceptibility_to0.61080330
58MP0000230_abnormal_systemic_arterial0.58207895
59MP0002638_abnormal_pupillary_reflex0.56366081
60MP0003279_aneurysm0.55478736
61MP0003656_abnormal_erythrocyte_physiolo0.55356093
62MP0004142_abnormal_muscle_tone0.53846040
63MP0002078_abnormal_glucose_homeostasis0.53540809
64MP0002128_abnormal_blood_circulation0.52632786
65MP0008961_abnormal_basal_metabolism0.50414502
66MP0005334_abnormal_fat_pad0.46398888
67MP0003705_abnormal_hypodermis_morpholog0.45190307
68MP0004270_analgesia0.44918425
69MP0005275_abnormal_skin_tensile0.44099963
70MP0010368_abnormal_lymphatic_system0.41416474
71MP0001346_abnormal_lacrimal_gland0.40014782
72MP0005319_abnormal_enzyme/_coenzyme0.39986704
73MP0005423_abnormal_somatic_nervous0.39547182
74MP0010030_abnormal_orbit_morphology0.38855632
75MP0001879_abnormal_lymphatic_vessel0.37108341
76MP0005167_abnormal_blood-brain_barrier0.37019887
77MP0005451_abnormal_body_composition0.36322067
78MP0004134_abnormal_chest_morphology0.36243040
79MP0002734_abnormal_mechanical_nocicepti0.35936026
80MP0005332_abnormal_amino_acid0.34215781
81MP0001299_abnormal_eye_distance/0.33953598
82MP0002114_abnormal_axial_skeleton0.33215927
83MP0003948_abnormal_gas_homeostasis0.33055740
84MP0000767_abnormal_smooth_muscle0.32407943
85MP0005452_abnormal_adipose_tissue0.31655092
86MP0005584_abnormal_enzyme/coenzyme_acti0.30601124
87MP0000762_abnormal_tongue_morphology0.29533960
88MP0002909_abnormal_adrenal_gland0.29333171
89MP0005083_abnormal_biliary_tract0.29187506
90MP0009250_abnormal_appendicular_skeleto0.28608895
91MP0005535_abnormal_body_temperature0.28579624
92MP0003045_fibrosis0.28444177
93MP0001853_heart_inflammation0.28366580
94MP0005503_abnormal_tendon_morphology0.28219221
95MP0005166_decreased_susceptibility_to0.28002992
96MP0009115_abnormal_fat_cell0.27254754
97MP0006276_abnormal_autonomic_nervous0.26122053
98MP0008569_lethality_at_weaning0.25693516
99MP0003566_abnormal_cell_adhesion0.25603039
100MP0002822_catalepsy0.24731329
101MP0002066_abnormal_motor_capabilities/c0.24651670
102MP0002925_abnormal_cardiovascular_devel0.24625553
103MP0008438_abnormal_cutaneous_collagen0.24515483
104MP0002876_abnormal_thyroid_physiology0.23408238
105MP0005645_abnormal_hypothalamus_physiol0.23266654
106MP0001943_abnormal_respiration0.22284890
107MP0005623_abnormal_meninges_morphology0.21399924
108MP0005187_abnormal_penis_morphology0.21146937
109MP0005376_homeostasis/metabolism_phenot0.21084522
110MP0004924_abnormal_behavior0.21036293
111MP0005386_behavior/neurological_phenoty0.21036293
112MP0001529_abnormal_vocalization0.20995972
113MP0000372_irregular_coat_pigmentation0.19416586
114MP0001614_abnormal_blood_vessel0.19225618
115MP0002067_abnormal_sensory_capabilities0.19224111
116MP0003959_abnormal_lean_body0.18658358
117MP0003195_calcinosis0.18547705
118MP0002118_abnormal_lipid_homeostasis0.18330751
119MP0002896_abnormal_bone_mineralization0.16936606
120MP0001784_abnormal_fluid_regulation0.16469467
121MP0009672_abnormal_birth_weight0.15697203
122MP0002970_abnormal_white_adipose0.14549887
123MP0002249_abnormal_larynx_morphology0.12737548

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)8.25022860
2Muscle fiber inclusion bodies (HP:0100299)7.87737004
3Exercise-induced muscle cramps (HP:0003710)7.74287488
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.56220611
5Muscle hypertrophy of the lower extremities (HP:0008968)7.27198774
6Calf muscle hypertrophy (HP:0008981)6.98938120
7Nemaline bodies (HP:0003798)6.97523919
8Type 1 muscle fiber predominance (HP:0003803)6.03270295
9Muscle fiber splitting (HP:0003555)5.96751519
10Hyporeflexia of lower limbs (HP:0002600)5.47783350
11Myoglobinuria (HP:0002913)5.45413485
12Sudden death (HP:0001699)5.21713754
13Distal arthrogryposis (HP:0005684)5.21581631
14Difficulty running (HP:0009046)5.16166786
15Abnormality of the calf musculature (HP:0001430)5.10420054
16EMG: myopathic abnormalities (HP:0003458)4.93945151
17Myopathic facies (HP:0002058)4.92330698
18Round ear (HP:0100830)4.63264488
19Increased connective tissue (HP:0009025)4.60374317
20Abnormality of the left ventricular outflow tract (HP:0011103)4.58760079
21Subaortic stenosis (HP:0001682)4.58760079
22Rhabdomyolysis (HP:0003201)4.48176096
23Ventricular tachycardia (HP:0004756)4.26938729
24Myotonia (HP:0002486)4.23340288
25Ulnar deviation of the wrist (HP:0003049)4.22742460
26Muscle stiffness (HP:0003552)4.20317850
27Asymmetric septal hypertrophy (HP:0001670)3.62166471
28Abnormality of skeletal muscle fiber size (HP:0012084)3.57222748
29Difficulty climbing stairs (HP:0003551)3.53349399
30Calcaneovalgus deformity (HP:0001848)3.53180308
31Neck muscle weakness (HP:0000467)3.41335062
32Lipoatrophy (HP:0100578)3.38665799
33Absent phalangeal crease (HP:0006109)3.36372463
34Increased variability in muscle fiber diameter (HP:0003557)3.31853181
35Deformed tarsal bones (HP:0008119)3.30934725
36Areflexia of lower limbs (HP:0002522)3.29708769
37Rimmed vacuoles (HP:0003805)3.23976413
38Atrial fibrillation (HP:0005110)3.20928174
39Distal lower limb muscle weakness (HP:0009053)3.06609675
40Dilated cardiomyopathy (HP:0001644)3.01061389
41Primary atrial arrhythmia (HP:0001692)2.97402116
42Bundle branch block (HP:0011710)2.89437852
43Supraventricular tachycardia (HP:0004755)2.86751799
44Right ventricular cardiomyopathy (HP:0011663)2.82864395
45Supraventricular arrhythmia (HP:0005115)2.80134717
46Malignant hyperthermia (HP:0002047)2.79361678
47Abnormal finger flexion creases (HP:0006143)2.76728241
48Frequent falls (HP:0002359)2.71013720
49Palpitations (HP:0001962)2.63476491
50Fetal akinesia sequence (HP:0001989)2.53283460
51EMG: neuropathic changes (HP:0003445)2.48739102
52Limb-girdle muscle atrophy (HP:0003797)2.47305258
53Abnormality of the neuromuscular junction (HP:0003398)2.46489760
54Fatigable weakness (HP:0003473)2.46489760
55Muscular dystrophy (HP:0003560)2.45785744
56Prolonged QT interval (HP:0001657)2.44952226
57Hypoplastic ischia (HP:0003175)2.40347502
58Generalized muscle weakness (HP:0003324)2.37697115
59Heart block (HP:0012722)2.37421910
60Gowers sign (HP:0003391)2.35910392
61Mildly elevated creatine phosphokinase (HP:0008180)2.34125279
62Ventricular arrhythmia (HP:0004308)2.33115657
63Facial diplegia (HP:0001349)2.32774885
64Hyperkalemia (HP:0002153)2.31738801
65Syncope (HP:0001279)2.30831775
66Abnormality of the hip-girdle musculature (HP:0001445)2.26986005
67Abnormality of the musculature of the pelvis (HP:0001469)2.26986005
68Bulbar palsy (HP:0001283)2.26159623
69Abnormal atrioventricular conduction (HP:0005150)2.25242514
70Proximal amyotrophy (HP:0007126)2.24250232
71Pelvic girdle muscle weakness (HP:0003749)2.22629931
72Shoulder girdle muscle weakness (HP:0003547)2.22462025
73Distal lower limb amyotrophy (HP:0008944)2.18368758
74Weak cry (HP:0001612)2.17377186
75Limb-girdle muscle weakness (HP:0003325)2.15126735
76Progressive muscle weakness (HP:0003323)2.09709826
77Centrally nucleated skeletal muscle fibers (HP:0003687)2.08863327
78Abnormality of the ischium (HP:0003174)2.08155915
79Scapular winging (HP:0003691)2.08120410
80Waddling gait (HP:0002515)2.07752297
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00909751
82Abnormality of the calcaneus (HP:0008364)2.00745989
83Atrioventricular block (HP:0001678)1.99659472
84Lower limb amyotrophy (HP:0007210)1.98435337
85Spinal rigidity (HP:0003306)1.96756378
86Abnormal mitochondria in muscle tissue (HP:0008316)1.95592232
87Left ventricular hypertrophy (HP:0001712)1.93254084
88Acute necrotizing encephalopathy (HP:0006965)1.91366933
89Testicular atrophy (HP:0000029)1.90628021
90Exercise intolerance (HP:0003546)1.90525177
91Slender build (HP:0001533)1.89198066
92Hepatic necrosis (HP:0002605)1.85891787
93Respiratory insufficiency due to muscle weakness (HP:0002747)1.82516249
94Ragged-red muscle fibers (HP:0003200)1.82378086
95Abnormality of the shoulder girdle musculature (HP:0001435)1.82199377
96Increased muscle lipid content (HP:0009058)1.79680969
97Paralysis (HP:0003470)1.78558032
98Long clavicles (HP:0000890)1.77286426
99Abnormal EKG (HP:0003115)1.76874757
100Ventricular fibrillation (HP:0001663)1.76728065
101Foot dorsiflexor weakness (HP:0009027)1.74290412
102Increased intramyocellular lipid droplets (HP:0012240)1.73211223
103Abnormality of the foot musculature (HP:0001436)1.72994001
104Ketoacidosis (HP:0001993)1.72420808
105Hip contracture (HP:0003273)1.71562750
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68658233
107Hyperalaninemia (HP:0003348)1.68658233
108Nonprogressive disorder (HP:0003680)1.66739203
109Popliteal pterygium (HP:0009756)1.60336327
110Type 2 muscle fiber atrophy (HP:0003554)1.55156845
111Metatarsus adductus (HP:0001840)1.53472373
112Ulnar deviation of finger (HP:0009465)1.50955636
113Muscle fiber atrophy (HP:0100295)1.44702202
114Limited hip movement (HP:0008800)1.38453725
115Oligomenorrhea (HP:0000876)1.36735645
116Steppage gait (HP:0003376)1.28606407
117Congenital hip dislocation (HP:0001374)1.28565911
118Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.28096829
119Insulin-resistant diabetes mellitus (HP:0000831)1.24297141
120Stridor (HP:0010307)1.19110502
121Easy fatigability (HP:0003388)1.18954343
122Neonatal hypotonia (HP:0001319)1.18944968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.53358957
2TTN6.74291388
3PHKG25.30510354
4PHKG15.30510354
5NME12.81022863
6PDK32.72279173
7PDK42.72279173
8MUSK2.48541599
9PINK12.48095772
10DMPK2.47789290
11PIK3CG2.38813096
12MAP2K32.27097248
13NEK12.16343756
14BCKDK2.14903223
15PIK3CA2.11626762
16TRIB32.03290968
17PDK21.78340147
18MAP3K71.74338113
19LMTK21.61778473
20PKN21.52338788
21MYLK1.50627742
22MAPK121.49347847
23TIE11.24575092
24STK241.19761031
25MARK11.08874189
26ZAK1.08389030
27MAP2K60.91583686
28MAP3K30.90408420
29PRKAA10.90406590
30PRKAA20.89397628
31TRPM70.86413995
32MOS0.86310053
33MAP2K40.85676587
34MAPKAPK30.84808329
35NEK90.83154612
36CCNB10.83131872
37DYRK1B0.77370284
38PRKD10.71898119
39ILK0.71633570
40CAMK2D0.70265031
41GRK70.69914216
42EPHB10.68741737
43MAP3K130.65274908
44PKN10.64445593
45MAP3K50.59775925
46ROCK10.59398647
47AKT20.59359481
48INSRR0.51859929
49CAMK2G0.50754008
50RIPK10.47748297
51MAPK110.43015795
52TAOK20.42904534
53PAK30.42710526
54CAMK2B0.40720363
55PRKACB0.40333497
56TGFBR20.40303699
57FLT30.40277624
58ERBB30.37931130
59KSR20.36863129
60SIK10.34625239
61STK38L0.34537509
62SGK20.34203208
63PTK60.33406262
64MAP3K110.33064852
65MAPK130.32852306
66TBK10.31718192
67TAOK10.30442050
68PRKACA0.29765945
69ROCK20.29662622
70RPS6KB10.29355337
71SGK10.27329434
72PRKG10.26520291
73MAPK70.26229629
74ICK0.25081146
75CAMK40.24714442
76RPS6KC10.24309475
77RPS6KL10.24309475
78CAMK2A0.22982101
79PDPK10.22911891
80KDR0.22496896
81MARK20.21567428
82STK40.21523319
83MAPK100.21515704
84RPS6KB20.21386290
85CDK190.21358965
86DAPK20.20642471
87ARAF0.20634564
88MAP3K10.20095392
89RPS6KA60.19953471
90SGK30.19510171
91WNK10.18846523
92RPS6KA30.18755420
93PDK10.18328227
94PRKACG0.18269821
95PDGFRA0.17012531
96LATS20.16949107
97STK380.16696723
98MAPK40.16249902
99CDC42BPA0.16216027
100MAP3K90.16167399
101PTK2B0.16008963
102RPS6KA10.15885311
103SGK4940.15763593
104SGK2230.15763593
105PRPF4B0.14410859
106NME20.13215560
107TYK20.12892705
108NLK0.12510711
109DAPK30.11624477
110CAMK10.10870309
111PRKCH0.10475880
112STK110.10145672
113RPS6KA20.09746137
114WNK40.09008699
115TNK20.08807412
116MARK30.08659928
117JAK10.08592329
118MAP2K10.08566141
119ZAP700.07974769
120RAF10.07709641
121MTOR0.05892704
122LIMK10.05691931
123MAP3K60.04375886
124BRAF0.04344382
125JAK20.04233291
126GSK3B0.04027100
127EEF2K0.03582734
128MAPK90.03189411
129PRKCE0.03177051
130MAPK30.03101241
131MAPK80.01948561
132MAPKAPK20.01873051
133CSNK1D0.01555316
134MAP3K100.00821477

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.47513349
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.33167906
3Cardiac muscle contraction_Homo sapiens_hsa042604.27011392
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.98003062
5Dilated cardiomyopathy_Homo sapiens_hsa054143.94119187
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.28815308
7Propanoate metabolism_Homo sapiens_hsa006403.03633024
8Parkinsons disease_Homo sapiens_hsa050122.83582310
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71665078
10Oxidative phosphorylation_Homo sapiens_hsa001902.69014232
11Carbon metabolism_Homo sapiens_hsa012002.38135430
12Fatty acid degradation_Homo sapiens_hsa000712.35620094
13Alzheimers disease_Homo sapiens_hsa050102.26359697
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15239882
15Starch and sucrose metabolism_Homo sapiens_hsa005002.00582142
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98956540
17Viral myocarditis_Homo sapiens_hsa054161.85215892
18Fatty acid metabolism_Homo sapiens_hsa012121.71812979
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70874864
20Pyruvate metabolism_Homo sapiens_hsa006201.62367407
21Glucagon signaling pathway_Homo sapiens_hsa049221.61946098
22Huntingtons disease_Homo sapiens_hsa050161.59643195
23Insulin resistance_Homo sapiens_hsa049311.59580872
24Insulin signaling pathway_Homo sapiens_hsa049101.54427811
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53480025
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.40923825
27Circadian rhythm_Homo sapiens_hsa047101.36616976
28Oxytocin signaling pathway_Homo sapiens_hsa049211.31944205
29Calcium signaling pathway_Homo sapiens_hsa040201.20890867
30Biosynthesis of amino acids_Homo sapiens_hsa012301.16911155
31Galactose metabolism_Homo sapiens_hsa000521.15370941
32AMPK signaling pathway_Homo sapiens_hsa041521.14736065
33Nitrogen metabolism_Homo sapiens_hsa009101.13416240
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11383585
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07730782
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02697250
37Arginine and proline metabolism_Homo sapiens_hsa003301.01147122
38Fructose and mannose metabolism_Homo sapiens_hsa000510.96615777
39Butanoate metabolism_Homo sapiens_hsa006500.88970930
40Fatty acid elongation_Homo sapiens_hsa000620.86969632
41Focal adhesion_Homo sapiens_hsa045100.85451749
42Tight junction_Homo sapiens_hsa045300.85049036
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84706768
44PPAR signaling pathway_Homo sapiens_hsa033200.82853018
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.81912322
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81118827
47HIF-1 signaling pathway_Homo sapiens_hsa040660.73556549
48Long-term potentiation_Homo sapiens_hsa047200.73125787
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68117872
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62935841
51beta-Alanine metabolism_Homo sapiens_hsa004100.62393866
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58126902
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.53389594
54Arginine biosynthesis_Homo sapiens_hsa002200.51264723
55Type II diabetes mellitus_Homo sapiens_hsa049300.49551043
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49515077
57Fatty acid biosynthesis_Homo sapiens_hsa000610.49493309
58Gastric acid secretion_Homo sapiens_hsa049710.47942741
59FoxO signaling pathway_Homo sapiens_hsa040680.46189522
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45327496
61Lysine degradation_Homo sapiens_hsa003100.44668805
62Pentose phosphate pathway_Homo sapiens_hsa000300.44000130
63Renin secretion_Homo sapiens_hsa049240.43099940
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42686298
65Long-term depression_Homo sapiens_hsa047300.39648946
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38774407
67Tryptophan metabolism_Homo sapiens_hsa003800.38440379
68GnRH signaling pathway_Homo sapiens_hsa049120.37937437
69Peroxisome_Homo sapiens_hsa041460.37602107
70Insulin secretion_Homo sapiens_hsa049110.36238964
71Salivary secretion_Homo sapiens_hsa049700.35201239
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.34778988
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34152739
74Adherens junction_Homo sapiens_hsa045200.33669879
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33382519
76Platelet activation_Homo sapiens_hsa046110.31527690
77Amoebiasis_Homo sapiens_hsa051460.31507185
78MAPK signaling pathway_Homo sapiens_hsa040100.30775063
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29741446
80VEGF signaling pathway_Homo sapiens_hsa043700.27471252
81Amphetamine addiction_Homo sapiens_hsa050310.27288394
82ECM-receptor interaction_Homo sapiens_hsa045120.26873870
83Phenylalanine metabolism_Homo sapiens_hsa003600.26651556
84Histidine metabolism_Homo sapiens_hsa003400.25880288
85mTOR signaling pathway_Homo sapiens_hsa041500.23537345
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23383680
87Metabolic pathways_Homo sapiens_hsa011000.22589077
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20564726
89Renal cell carcinoma_Homo sapiens_hsa052110.18733929
90cAMP signaling pathway_Homo sapiens_hsa040240.18180359
91Proteoglycans in cancer_Homo sapiens_hsa052050.18115073
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16236233
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15994465
94Glioma_Homo sapiens_hsa052140.11876025
95Melanogenesis_Homo sapiens_hsa049160.10833392
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10003036
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09668425
98Olfactory transduction_Homo sapiens_hsa047400.09501422
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.08616933
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08145062
101Oocyte meiosis_Homo sapiens_hsa041140.07896884
102Thyroid cancer_Homo sapiens_hsa052160.07506608
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.07087402
104Toxoplasmosis_Homo sapiens_hsa051450.06272660
105Pancreatic secretion_Homo sapiens_hsa049720.04927445
106Cholinergic synapse_Homo sapiens_hsa047250.04851500
107Circadian entrainment_Homo sapiens_hsa047130.04347032
108Regulation of autophagy_Homo sapiens_hsa041400.03715500
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02755183
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.02512254
111ABC transporters_Homo sapiens_hsa020100.01488739
112Acute myeloid leukemia_Homo sapiens_hsa052210.00517602
113Sulfur relay system_Homo sapiens_hsa041220.00332769
114Tyrosine metabolism_Homo sapiens_hsa003500.00193807
115Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0524675
116Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0442212
117Linoleic acid metabolism_Homo sapiens_hsa00591-0.0424016
118Salmonella infection_Homo sapiens_hsa05132-0.0353142
119Fat digestion and absorption_Homo sapiens_hsa04975-0.0316735
120Notch signaling pathway_Homo sapiens_hsa04330-0.0142899
121Purine metabolism_Homo sapiens_hsa00230-0.0048274

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