ANKRD26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)4.61274279
2central nervous system myelination (GO:0022010)4.40877233
3axon ensheathment in central nervous system (GO:0032291)4.40877233
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.26513573
5establishment of integrated proviral latency (GO:0075713)4.11311654
6mitotic sister chromatid cohesion (GO:0007064)3.97430519
7kinetochore assembly (GO:0051382)3.96371701
8DNA unwinding involved in DNA replication (GO:0006268)3.67758899
9otic vesicle formation (GO:0030916)3.65839766
10positive regulation of cell cycle checkpoint (GO:1901978)3.59745485
11intraciliary transport (GO:0042073)3.57766254
12chromatin remodeling at centromere (GO:0031055)3.47874687
13metaphase plate congression (GO:0051310)3.46496767
14CENP-A containing nucleosome assembly (GO:0034080)3.46492737
15meiotic chromosome segregation (GO:0045132)3.46104168
16somite development (GO:0061053)3.46010371
17regulation of DNA endoreduplication (GO:0032875)3.44952888
18mitotic metaphase plate congression (GO:0007080)3.42406747
19mitotic chromosome condensation (GO:0007076)3.41331984
20epithelial cilium movement (GO:0003351)3.36306496
21sister chromatid segregation (GO:0000819)3.34898453
22microtubule depolymerization (GO:0007019)3.31936198
23limb bud formation (GO:0060174)3.30025386
24mitotic sister chromatid segregation (GO:0000070)3.28971604
25regulation of mitotic spindle checkpoint (GO:1903504)3.21377175
26regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.21377175
27DNA replication initiation (GO:0006270)3.21344991
28pyrimidine nucleobase catabolic process (GO:0006208)3.20067247
29DNA replication checkpoint (GO:0000076)3.19576798
30retinal ganglion cell axon guidance (GO:0031290)3.18669876
31behavioral response to nicotine (GO:0035095)3.18538013
32attachment of spindle microtubules to kinetochore (GO:0008608)3.16782597
33telomere maintenance via telomerase (GO:0007004)3.16321842
34DNA replication-independent nucleosome organization (GO:0034724)3.13010096
35DNA replication-independent nucleosome assembly (GO:0006336)3.13010096
36establishment of viral latency (GO:0019043)3.12397090
37regulation of centriole replication (GO:0046599)3.10477942
38DNA ligation (GO:0006266)3.10234306
39negative regulation of DNA-dependent DNA replication (GO:2000104)3.07730657
40histone exchange (GO:0043486)3.03290039
41nuclear pore complex assembly (GO:0051292)3.01899984
42neuronal stem cell maintenance (GO:0097150)2.99891063
43mRNA splice site selection (GO:0006376)2.99169629
44cell proliferation in forebrain (GO:0021846)2.94813174
45microtubule polymerization or depolymerization (GO:0031109)2.94781127
46fatty acid elongation (GO:0030497)2.94221029
47presynaptic membrane assembly (GO:0097105)2.93075296
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92618718
49centriole replication (GO:0007099)2.91877865
50mitotic recombination (GO:0006312)2.91680925
51cilium movement (GO:0003341)2.91595011
52establishment of chromosome localization (GO:0051303)2.90812379
53olfactory bulb development (GO:0021772)2.88006577
54positive regulation of histone H3-K4 methylation (GO:0051571)2.86873002
55nuclear pore organization (GO:0006999)2.85024891
56substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.83962496
57substrate-independent telencephalic tangential migration (GO:0021826)2.83962496
58protein localization to cilium (GO:0061512)2.82848550
59cilium organization (GO:0044782)2.82344018
60cilium morphogenesis (GO:0060271)2.81049699
61forebrain neuron differentiation (GO:0021879)2.80587981
62DNA strand elongation involved in DNA replication (GO:0006271)2.80218093
63regulation of telomere maintenance (GO:0032204)2.80133276
64cilium assembly (GO:0042384)2.77932241
65resolution of meiotic recombination intermediates (GO:0000712)2.76610094
66neuron fate determination (GO:0048664)2.75583752
67spindle checkpoint (GO:0031577)2.73103575
68presynaptic membrane organization (GO:0097090)2.72958152
69negative regulation of translation, ncRNA-mediated (GO:0040033)2.72530458
70regulation of translation, ncRNA-mediated (GO:0045974)2.72530458
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72530458
72neural tube formation (GO:0001841)2.71830025
73telomere maintenance via recombination (GO:0000722)2.71408122
74axoneme assembly (GO:0035082)2.70729646
75nonmotile primary cilium assembly (GO:0035058)2.70157592
76RNA-dependent DNA replication (GO:0006278)2.69843673
77sister chromatid cohesion (GO:0007062)2.68999933
78somite rostral/caudal axis specification (GO:0032525)2.68539788
79telomere maintenance via semi-conservative replication (GO:0032201)2.68488051
80DNA strand elongation (GO:0022616)2.67132037
81limb development (GO:0060173)2.66264863
82appendage development (GO:0048736)2.66264863
83nucleotide-excision repair, DNA gap filling (GO:0006297)2.66026257
84maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64757309
85DNA duplex unwinding (GO:0032508)2.63994555
86neuron cell-cell adhesion (GO:0007158)2.63760029
87telomere maintenance via telomere lengthening (GO:0010833)2.63264002
88establishment of protein localization to mitochondrial membrane (GO:0090151)2.62945890
89DNA geometric change (GO:0032392)2.61942592
90regulation of cilium movement (GO:0003352)2.61095609
91spindle assembly checkpoint (GO:0071173)2.60469390
92histone H2B ubiquitination (GO:0033523)2.59195976
93retina layer formation (GO:0010842)2.58296971
94neuron recognition (GO:0008038)2.58155743
95regulation of spindle checkpoint (GO:0090231)2.56823833
96histone-serine phosphorylation (GO:0035404)2.55803029
97DNA topological change (GO:0006265)2.55516056
98synapsis (GO:0007129)2.55372737
99regulation of meiosis I (GO:0060631)2.54603927
100regulation of sister chromatid segregation (GO:0033045)2.54373105
101regulation of mitotic sister chromatid separation (GO:0010965)2.54373105
102regulation of mitotic sister chromatid segregation (GO:0033047)2.54373105
103chaperone-mediated protein transport (GO:0072321)2.54012241
104mitotic spindle checkpoint (GO:0071174)2.53906032
105regulation of centrosome cycle (GO:0046605)2.53184062
106mitotic spindle assembly checkpoint (GO:0007094)2.51952789
107reciprocal DNA recombination (GO:0035825)2.51804310
108reciprocal meiotic recombination (GO:0007131)2.51804310
109DNA replication-dependent nucleosome assembly (GO:0006335)2.51184377
110DNA replication-dependent nucleosome organization (GO:0034723)2.51184377
111regulation of RNA export from nucleus (GO:0046831)2.50703014
112nucleobase catabolic process (GO:0046113)2.50183561
113chromatin assembly or disassembly (GO:0006333)2.49970975
114axonemal dynein complex assembly (GO:0070286)2.49750857
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49708796
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.49422741
117regulation of histone H3-K9 methylation (GO:0051570)2.49340236
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.49327339
119pre-miRNA processing (GO:0031054)2.48913985
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.48891759
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.48751357
122negative regulation of sister chromatid segregation (GO:0033046)2.48751357
123negative regulation of mitotic sister chromatid separation (GO:2000816)2.48751357
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.48751357
125regulation of centrosome duplication (GO:0010824)2.48234259
126regulation of telomere maintenance via telomerase (GO:0032210)2.48150769
127negative regulation of mRNA processing (GO:0050686)2.47584680
128nephron epithelium morphogenesis (GO:0072088)2.47315998
129nephron tubule morphogenesis (GO:0072078)2.47315998
130chromosome segregation (GO:0007059)2.47293456
131replication fork processing (GO:0031297)2.46530540
132postsynaptic membrane organization (GO:0001941)2.46528953
133intra-S DNA damage checkpoint (GO:0031573)2.45663055
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45488231
135centrosome organization (GO:0051297)2.44773659
136protein polyglutamylation (GO:0018095)2.44402230
137negative regulation of chromosome segregation (GO:0051985)2.44302760
138smoothened signaling pathway (GO:0007224)2.44291101
139establishment of protein localization to Golgi (GO:0072600)2.44017266
140spliceosomal complex assembly (GO:0000245)2.43327592
141microtubule organizing center organization (GO:0031023)2.42573185
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42565117
143DNA methylation involved in gamete generation (GO:0043046)2.42534563
144microtubule nucleation (GO:0007020)2.41859081
145axonal fasciculation (GO:0007413)2.41797435
146positive regulation of chromosome segregation (GO:0051984)2.41738923
147regulation of chromosome segregation (GO:0051983)2.41604002
148cerebral cortex radially oriented cell migration (GO:0021799)2.41328820
149protein localization to kinetochore (GO:0034501)2.41215408
150transmission of nerve impulse (GO:0019226)2.40644001
151regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40493684
152hindbrain development (GO:0030902)2.40261476
153piRNA metabolic process (GO:0034587)2.40051506
154isotype switching (GO:0045190)2.39671220
155somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.39671220
156head development (GO:0060322)2.39059653
157membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37658191
158microtubule anchoring (GO:0034453)2.35118766
159response to pheromone (GO:0019236)2.32809263
160behavioral response to ethanol (GO:0048149)2.31807876
161DNA double-strand break processing (GO:0000729)2.31766375
162kidney morphogenesis (GO:0060993)2.31567397
163detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31230631
164spinal cord association neuron differentiation (GO:0021527)2.29044376
165regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.29040838
166mitochondrial respiratory chain complex I assembly (GO:0032981)2.28059195
167NADH dehydrogenase complex assembly (GO:0010257)2.28059195
168mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.28059195
169protein complex biogenesis (GO:0070271)2.26969776
170cellular component assembly involved in morphogenesis (GO:0010927)2.26285401
171cilium or flagellum-dependent cell motility (GO:0001539)2.25405448
172protein localization to synapse (GO:0035418)2.24668883
173mechanosensory behavior (GO:0007638)2.23777298
174tongue development (GO:0043586)2.22791124
175determination of left/right symmetry (GO:0007368)2.21294462
176double-strand break repair via homologous recombination (GO:0000724)2.20567393
177forebrain neuron development (GO:0021884)2.20537523
178cell differentiation in spinal cord (GO:0021515)2.20505922
179recombinational repair (GO:0000725)2.20127491
180negative regulation of astrocyte differentiation (GO:0048712)2.19820148
181dendritic spine morphogenesis (GO:0060997)2.19691720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34504425
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.43554187
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.40839260
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31399722
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.25692687
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.86663727
7GBX2_23144817_ChIP-Seq_PC3_Human2.64498533
8FUS_26573619_Chip-Seq_HEK293_Human2.63814971
9ZNF274_21170338_ChIP-Seq_K562_Hela2.57668993
10EZH2_22144423_ChIP-Seq_EOC_Human2.51450898
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38246968
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34716082
13EWS_26573619_Chip-Seq_HEK293_Human2.24445884
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19911357
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12933050
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03709280
17TAF15_26573619_Chip-Seq_HEK293_Human2.03109379
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90582455
19YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84395008
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78643443
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.76653201
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76275713
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66468786
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62762205
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.61770790
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.60359099
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57042753
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56941136
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55683152
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54480133
31AR_21909140_ChIP-Seq_LNCAP_Human1.53767414
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52091426
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50486245
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50014567
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.49066438
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48365946
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48166803
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.47254898
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46444103
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45143043
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45143043
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44990442
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.44708041
44IRF1_19129219_ChIP-ChIP_H3396_Human1.43583521
45CBP_20019798_ChIP-Seq_JUKART_Human1.43171194
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43171194
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42708180
48MYC_18940864_ChIP-ChIP_HL60_Human1.42616461
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42464806
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41850161
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41221026
52IGF1R_20145208_ChIP-Seq_DFB_Human1.39547144
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36857147
54P300_19829295_ChIP-Seq_ESCs_Human1.36338607
55AR_25329375_ChIP-Seq_VCAP_Human1.36047500
56RNF2_27304074_Chip-Seq_NSC_Mouse1.35517598
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.34389570
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33925006
59REST_21632747_ChIP-Seq_MESCs_Mouse1.32841503
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30471186
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28399106
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.28242650
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27797127
64BCAT_22108803_ChIP-Seq_LS180_Human1.27775773
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.27484000
66RUNX2_22187159_ChIP-Seq_PCA_Human1.26378444
67SOX9_26525672_Chip-Seq_HEART_Mouse1.24391029
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.23836564
69* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19453374
70STAT3_23295773_ChIP-Seq_U87_Human1.18530374
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18423936
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18268194
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16958577
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16837473
75ELK1_19687146_ChIP-ChIP_HELA_Human1.16732956
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.16084385
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.15663083
78VDR_22108803_ChIP-Seq_LS180_Human1.15166642
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14702159
80ER_23166858_ChIP-Seq_MCF-7_Human1.14692692
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14009699
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13066082
83TCF4_23295773_ChIP-Seq_U87_Human1.12196958
84TCF4_22108803_ChIP-Seq_LS180_Human1.11755956
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.11097796
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10467382
87MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09470977
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09387285
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08715090
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.08246605
91SMAD4_21799915_ChIP-Seq_A2780_Human1.07763359
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07494819
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07418159
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05797926
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05776336
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.04538642
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04136685
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.04005649
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03435284
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03406241
101TP53_22573176_ChIP-Seq_HFKS_Human1.03062366
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.02261222
103TP53_16413492_ChIP-PET_HCT116_Human1.02109709
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01989944
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01416471
106* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01410573
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01069749
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.00898534
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00818909
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99624229
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99511386
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99429575
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99335282
114JUN_21703547_ChIP-Seq_K562_Human0.99266255
115SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98993810
116CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98821733
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.98653883
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98603524
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98452882
120EZH2_27304074_Chip-Seq_ESCs_Mouse0.98294328
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97897613
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.97022072
123MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96404327
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95347121
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94879437
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94479974
127GABP_17652178_ChIP-ChIP_JURKAT_Human0.94475116
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94069424
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93719832
130P53_22387025_ChIP-Seq_ESCs_Mouse0.93533839
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93482510
132P300_18555785_Chip-Seq_ESCs_Mouse0.92915309
133JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92649478
134* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90689584
135SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90611961
136LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90597586
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90121566
138STAT3_18555785_Chip-Seq_ESCs_Mouse0.89926671
139TTF2_22483619_ChIP-Seq_HELA_Human0.89469842
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88833195
141AR_21572438_ChIP-Seq_LNCaP_Human0.88814369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.31323188
2MP0010094_abnormal_chromosome_stability3.13618786
3MP0003123_paternal_imprinting3.11153583
4MP0003121_genomic_imprinting3.01024960
5MP0003880_abnormal_central_pattern2.68518514
6MP0008877_abnormal_DNA_methylation2.68126351
7MP0003787_abnormal_imprinting2.63750948
8MP0003111_abnormal_nucleus_morphology2.58338756
9MP0001188_hyperpigmentation2.44368051
10MP0008058_abnormal_DNA_repair2.41283828
11MP0002653_abnormal_ependyma_morphology2.27740146
12MP0003077_abnormal_cell_cycle2.19934972
13MP0003122_maternal_imprinting2.18515980
14MP0005423_abnormal_somatic_nervous2.13275585
15MP0010030_abnormal_orbit_morphology1.96164593
16MP0005171_absent_coat_pigmentation1.92390134
17MP0008789_abnormal_olfactory_epithelium1.90806355
18MP0003937_abnormal_limbs/digits/tail_de1.90492292
19MP0006292_abnormal_olfactory_placode1.89445168
20MP0004957_abnormal_blastocyst_morpholog1.88728388
21MP0008932_abnormal_embryonic_tissue1.85694821
22MP0000566_synostosis1.84494971
23MP0006276_abnormal_autonomic_nervous1.79877280
24MP0003693_abnormal_embryo_hatching1.79796694
25MP0005394_taste/olfaction_phenotype1.71572068
26MP0005499_abnormal_olfactory_system1.71572068
27MP0004270_analgesia1.65146378
28MP0006072_abnormal_retinal_apoptosis1.64124373
29MP0005551_abnormal_eye_electrophysiolog1.63476794
30MP0002938_white_spotting1.62564086
31MP0003890_abnormal_embryonic-extraembry1.61483937
32MP0001529_abnormal_vocalization1.57606926
33MP0000778_abnormal_nervous_system1.54787508
34MP0003136_yellow_coat_color1.53909391
35MP0002233_abnormal_nose_morphology1.52576742
36MP0003950_abnormal_plasma_membrane1.51912345
37MP0009379_abnormal_foot_pigmentation1.50801253
38MP0002234_abnormal_pharynx_morphology1.45741496
39MP0001984_abnormal_olfaction1.43377100
40MP0001485_abnormal_pinna_reflex1.42980952
41MP0001486_abnormal_startle_reflex1.42002170
42MP0002837_dystrophic_cardiac_calcinosis1.41835510
43MP0002736_abnormal_nociception_after1.40280283
44MP0005253_abnormal_eye_physiology1.39162052
45MP0005409_darkened_coat_color1.37855649
46MP0002272_abnormal_nervous_system1.37204259
47MP0001968_abnormal_touch/_nociception1.35460541
48MP0000920_abnormal_myelination1.29775475
49MP0004742_abnormal_vestibular_system1.28804214
50MP0001293_anophthalmia1.27999385
51MP0003718_maternal_effect1.26512364
52MP0003861_abnormal_nervous_system1.25323275
53MP0003385_abnormal_body_wall1.22940353
54MP0003635_abnormal_synaptic_transmissio1.22456965
55MP0009046_muscle_twitch1.20569353
56MP0003195_calcinosis1.20506353
57MP0008007_abnormal_cellular_replicative1.19735946
58MP0004133_heterotaxia1.18318227
59MP0000631_abnormal_neuroendocrine_gland1.18254448
60MP0002102_abnormal_ear_morphology1.17600084
61MP0004885_abnormal_endolymph1.17596067
62MP0009745_abnormal_behavioral_response1.16297528
63MP0004142_abnormal_muscle_tone1.14706123
64MP0001905_abnormal_dopamine_level1.14592129
65MP0002210_abnormal_sex_determination1.14352890
66MP0005391_vision/eye_phenotype1.13443912
67MP0008995_early_reproductive_senescence1.12707488
68MP0002064_seizures1.12465153
69MP0002084_abnormal_developmental_patter1.11663410
70MP0003119_abnormal_digestive_system1.11662987
71MP0002160_abnormal_reproductive_system1.09756162
72MP0001299_abnormal_eye_distance/1.09207737
73MP0002882_abnormal_neuron_morphology1.08804547
74MP0002752_abnormal_somatic_nervous1.08194308
75MP0002751_abnormal_autonomic_nervous1.08068513
76MP0005248_abnormal_Harderian_gland1.07862947
77MP0002085_abnormal_embryonic_tissue1.07402348
78MP0000427_abnormal_hair_cycle1.07287707
79MP0002572_abnormal_emotion/affect_behav1.07132009
80MP0000026_abnormal_inner_ear1.06365472
81MP0005646_abnormal_pituitary_gland1.05455193
82MP0003632_abnormal_nervous_system1.05449150
83MP0002184_abnormal_innervation1.05085501
84MP0001730_embryonic_growth_arrest1.03974268
85MP0000955_abnormal_spinal_cord1.03519393
86MP0000049_abnormal_middle_ear1.01874936
87MP0002152_abnormal_brain_morphology1.01749863
88MP0001929_abnormal_gametogenesis1.01575206
89MP0000350_abnormal_cell_proliferation1.00071870
90MP0002735_abnormal_chemical_nociception0.99219231
91MP0002638_abnormal_pupillary_reflex0.99083119
92MP0004145_abnormal_muscle_electrophysio0.98967815
93MP0000569_abnormal_digit_pigmentation0.98587963
94MP0000653_abnormal_sex_gland0.97982878
95MP0002063_abnormal_learning/memory/cond0.97654605
96MP0001145_abnormal_male_reproductive0.96616969
97MP0003315_abnormal_perineum_morphology0.96447870
98MP0005195_abnormal_posterior_eye0.96112252
99MP0002229_neurodegeneration0.95336946
100MP0002734_abnormal_mechanical_nocicepti0.94493215
101MP0005187_abnormal_penis_morphology0.94016603
102MP0009703_decreased_birth_body0.91770532
103MP0002557_abnormal_social/conspecific_i0.91665190
104MP0002163_abnormal_gland_morphology0.91412242
105MP0001697_abnormal_embryo_size0.91153341
106MP0000462_abnormal_digestive_system0.91066592
107MP0002697_abnormal_eye_size0.90806713
108MP0001177_atelectasis0.90724297
109MP0003698_abnormal_male_reproductive0.90374784
110MP0000647_abnormal_sebaceous_gland0.90372090
111MP0002067_abnormal_sensory_capabilities0.89957098
112MP0004859_abnormal_synaptic_plasticity0.89890533
113MP0001963_abnormal_hearing_physiology0.89842611
114MP0004215_abnormal_myocardial_fiber0.88968610
115MP0002928_abnormal_bile_duct0.88688360
116MP0003137_abnormal_impulse_conducting0.85026807
117MP0003938_abnormal_ear_development0.84994516
118MP0001986_abnormal_taste_sensitivity0.84426391
119MP0001672_abnormal_embryogenesis/_devel0.83949964
120MP0005380_embryogenesis_phenotype0.83949964
121MP0002095_abnormal_skin_pigmentation0.83897890
122MP0004134_abnormal_chest_morphology0.83801184
123MP0004043_abnormal_pH_regulation0.83531291
124MP0003942_abnormal_urinary_system0.83273744
125MP0003567_abnormal_fetal_cardiomyocyte0.83215209
126MP0003755_abnormal_palate_morphology0.82522791
127MP0002114_abnormal_axial_skeleton0.81292300
128MP0009250_abnormal_appendicular_skeleto0.80755583
129MP0003935_abnormal_craniofacial_develop0.79199399
130MP0003786_premature_aging0.78176406
131MP0001286_abnormal_eye_development0.77727614
132MP0000537_abnormal_urethra_morphology0.77654756
133MP0002116_abnormal_craniofacial_bone0.77333141
134MP0003011_delayed_dark_adaptation0.77266578
135MP0002092_abnormal_eye_morphology0.76746932

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.99461079
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90132526
3Volvulus (HP:0002580)3.18856629
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.07034009
5Degeneration of the lateral corticospinal tracts (HP:0002314)3.07034009
6Chronic hepatic failure (HP:0100626)3.00498796
7Colon cancer (HP:0003003)2.93833290
8Abnormality of the renal medulla (HP:0100957)2.89775038
9Abnormality of the labia minora (HP:0012880)2.82936550
10Abnormality of chromosome stability (HP:0003220)2.69426866
11Rib fusion (HP:0000902)2.68557979
12Oligodactyly (hands) (HP:0001180)2.63366287
13Nephroblastoma (Wilms tumor) (HP:0002667)2.63034913
14Type II lissencephaly (HP:0007260)2.61440845
15Abnormality of the corticospinal tract (HP:0002492)2.52815428
16Cystic liver disease (HP:0006706)2.49937038
17Embryonal renal neoplasm (HP:0011794)2.47790880
18Congenital stationary night blindness (HP:0007642)2.46822215
19Medulloblastoma (HP:0002885)2.46525665
20Ectopic kidney (HP:0000086)2.45756486
21Genital tract atresia (HP:0001827)2.45003584
22Sclerocornea (HP:0000647)2.44484679
23Gait imbalance (HP:0002141)2.43616147
24Septo-optic dysplasia (HP:0100842)2.42436067
25Vaginal atresia (HP:0000148)2.40188762
26Intestinal atresia (HP:0011100)2.36958825
27Cerebellar dysplasia (HP:0007033)2.36750037
28Anophthalmia (HP:0000528)2.35028659
29Congenital primary aphakia (HP:0007707)2.32980208
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.28102131
31Meckel diverticulum (HP:0002245)2.26685393
32Abnormality of midbrain morphology (HP:0002418)2.26374686
33Molar tooth sign on MRI (HP:0002419)2.26374686
34Neoplasm of the oral cavity (HP:0100649)2.24917890
35Absent/shortened dynein arms (HP:0200106)2.23881965
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.23881965
37Hyperventilation (HP:0002883)2.23480119
38Optic nerve hypoplasia (HP:0000609)2.22339341
39Anencephaly (HP:0002323)2.21866556
40Postaxial hand polydactyly (HP:0001162)2.21555979
41Abnormal hair whorl (HP:0010721)2.21211691
42Medial flaring of the eyebrow (HP:0010747)2.19932334
43Abnormality of the renal cortex (HP:0011035)2.18842797
44Abnormal lung lobation (HP:0002101)2.18333076
45Postaxial foot polydactyly (HP:0001830)2.17086422
46Oligodactyly (HP:0012165)2.15260873
47Duplicated collecting system (HP:0000081)2.15178379
48Abnormality of the ileum (HP:0001549)2.14751430
49Abnormal ciliary motility (HP:0012262)2.10135417
50Tubulointerstitial nephritis (HP:0001970)2.09733123
51Attenuation of retinal blood vessels (HP:0007843)2.08450401
52Nephrogenic diabetes insipidus (HP:0009806)2.06498656
53Hepatoblastoma (HP:0002884)2.04328379
54Poor coordination (HP:0002370)2.02105778
55Morphological abnormality of the inner ear (HP:0011390)2.01966954
56Cerebral hypomyelination (HP:0006808)2.01501265
57Abnormal respiratory epithelium morphology (HP:0012253)2.01325025
58Abnormal respiratory motile cilium morphology (HP:0005938)2.01325025
59Male pseudohermaphroditism (HP:0000037)1.99126034
60Abnormality of chromosome segregation (HP:0002916)1.98981589
61Gastrointestinal atresia (HP:0002589)1.96807383
62Midline defect of the nose (HP:0004122)1.96049253
63Occipital encephalocele (HP:0002085)1.95859392
64Abnormal number of incisors (HP:0011064)1.95516041
65True hermaphroditism (HP:0010459)1.94597114
66Congenital hepatic fibrosis (HP:0002612)1.94454705
67Aplasia/Hypoplasia of the uvula (HP:0010293)1.94336355
68Triphalangeal thumb (HP:0001199)1.94281374
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93664174
70Abnormal respiratory motile cilium physiology (HP:0012261)1.92267899
71Abnormality of the preputium (HP:0100587)1.90269923
72Tented upper lip vermilion (HP:0010804)1.89673216
73Abnormality of the septum pellucidum (HP:0007375)1.89010873
74Tubular atrophy (HP:0000092)1.88974170
75Lissencephaly (HP:0001339)1.88512687
76Nephronophthisis (HP:0000090)1.88166580
77Atonic seizures (HP:0010819)1.87927639
78Esophageal atresia (HP:0002032)1.87514972
79Protruding tongue (HP:0010808)1.87221766
80Abnormality of cochlea (HP:0000375)1.86470271
81Supernumerary spleens (HP:0009799)1.85998267
82Partial agenesis of the corpus callosum (HP:0001338)1.85432650
83Narrow forehead (HP:0000341)1.85255437
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84724909
85Abnormality of the renal collecting system (HP:0004742)1.84174815
86Short tibia (HP:0005736)1.82711325
87Short 4th metacarpal (HP:0010044)1.82351163
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82351163
89Dandy-Walker malformation (HP:0001305)1.82133023
90Retinal dysplasia (HP:0007973)1.81703064
91Abnormal pancreas size (HP:0012094)1.81186576
92Progressive cerebellar ataxia (HP:0002073)1.81100119
93Reticulocytopenia (HP:0001896)1.80825220
94Bifid tongue (HP:0010297)1.80511991
95Bony spicule pigmentary retinopathy (HP:0007737)1.79713242
96Gastroesophageal reflux (HP:0002020)1.79272210
97Median cleft lip (HP:0000161)1.78890772
98Abnormality of the ischium (HP:0003174)1.78888838
99Birth length less than 3rd percentile (HP:0003561)1.78690005
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.77800475
101Hypoplastic ischia (HP:0003175)1.76830400
102Supernumerary bones of the axial skeleton (HP:0009144)1.76557017
103Absent septum pellucidum (HP:0001331)1.75846691
104Highly arched eyebrow (HP:0002553)1.75177700
105Broad-based gait (HP:0002136)1.75015791
106Cupped ear (HP:0000378)1.74017994
107Neoplasm of the adrenal cortex (HP:0100641)1.73859538
108Growth hormone deficiency (HP:0000824)1.72954905
109Hypoplastic iliac wings (HP:0002866)1.72844014
110Sloping forehead (HP:0000340)1.72593947
111Rhinitis (HP:0012384)1.72399519
112Hyperglycinemia (HP:0002154)1.72287403
113Duplication of thumb phalanx (HP:0009942)1.71853473
114Pancreatic fibrosis (HP:0100732)1.71630353
115Preaxial foot polydactyly (HP:0001841)1.70055605
116Shawl scrotum (HP:0000049)1.69271753
117Pancreatic cysts (HP:0001737)1.68582930
118Aganglionic megacolon (HP:0002251)1.68548122
119Bile duct proliferation (HP:0001408)1.68196054
120Abnormal biliary tract physiology (HP:0012439)1.68196054
121Supernumerary ribs (HP:0005815)1.67580123
122Rhabdomyosarcoma (HP:0002859)1.67245712
123Small intestinal stenosis (HP:0012848)1.67087890
124Duodenal stenosis (HP:0100867)1.67087890
125Focal motor seizures (HP:0011153)1.66584673
126Aplasia/Hypoplasia of the tibia (HP:0005772)1.66381021
127Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65224354
128Dyskinesia (HP:0100660)1.65147596
129Adrenal hypoplasia (HP:0000835)1.64827772
130Epileptic encephalopathy (HP:0200134)1.64502392
131Aqueductal stenosis (HP:0002410)1.64403181
132Abnormality of the incisor (HP:0000676)1.63706591
133Insidious onset (HP:0003587)1.62966738
134Termporal pattern (HP:0011008)1.62966738
135Abnormality of DNA repair (HP:0003254)1.62672023
136Abnormal rod and cone electroretinograms (HP:0008323)1.62237161
137Specific learning disability (HP:0001328)1.61675909
138Thyroid-stimulating hormone excess (HP:0002925)1.60874121
139Decreased lacrimation (HP:0000633)1.60788140
140Relative macrocephaly (HP:0004482)1.59980344
141Holoprosencephaly (HP:0001360)1.59356132
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.58122962
143Febrile seizures (HP:0002373)1.57300840
144Astigmatism (HP:0000483)1.56197292
145Short foot (HP:0001773)1.55593339
146Impulsivity (HP:0100710)1.55221262
147Myelomeningocele (HP:0002475)1.54861777
148Excessive salivation (HP:0003781)1.54675721
149Drooling (HP:0002307)1.54675721
150Aplasia/Hypoplasia of the patella (HP:0006498)1.54421266
151Dental crowding (HP:0000678)1.53694375
152Cutaneous finger syndactyly (HP:0010554)1.52933703
153Patellar aplasia (HP:0006443)1.52170801
154Broad alveolar ridges (HP:0000187)1.51898540
155Prominent nasal bridge (HP:0000426)1.51797696
156Abnormal auditory evoked potentials (HP:0006958)1.51292222
157Absent radius (HP:0003974)1.51205950
158Microglossia (HP:0000171)1.50500754
159Trigonocephaly (HP:0000243)1.49024404
160Preaxial hand polydactyly (HP:0001177)1.47727360
161Sensory axonal neuropathy (HP:0003390)1.45759675
162Anteriorly placed anus (HP:0001545)1.44815163
163Abnormality of the nasolacrimal system (HP:0000614)1.44680446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.00810674
2FRK3.96711325
3CASK3.44241972
4PNCK2.72667781
5WNK32.71653312
6MKNK12.39652046
7MKNK22.28871557
8SRPK12.20181208
9PBK2.17581748
10MAP4K22.11647708
11FGFR22.06059464
12STK392.02319699
13TTK2.01090583
14CDK121.84139038
15PINK11.82871192
16MAP2K71.67100706
17ZAK1.67087959
18OXSR11.62869622
19CDK81.57713716
20MAP3K41.56928914
21PLK31.55759168
22BUB11.54554082
23CHEK21.51780264
24PLK41.51068623
25NTRK31.49521201
26BMPR1B1.41946730
27PLK21.39503292
28PAK31.39164606
29MAPK131.38208885
30VRK11.37158636
31OBSCN1.37132001
32NEK21.36988460
33PLK11.36748199
34TSSK61.36547152
35INSRR1.34936800
36PRPF4B1.34769743
37BRD41.34566054
38WEE11.34174276
39ACVR1B1.32280136
40PIK3CA1.31050695
41ATR1.23855615
42AKT31.23519846
43GRK11.23438269
44UHMK11.22139746
45MAPKAPK51.21177293
46BRAF1.19591330
47CHEK11.17507248
48MELK1.12880566
49CCNB11.12575317
50MAP3K61.08692381
51PKN11.07608004
52LATS11.07559613
53STK161.07529382
54ATM1.07367826
55TNIK1.04338822
56STK38L1.01643589
57CSNK1G31.01397481
58ADRBK21.00098185
59CDK190.99610928
60PASK0.98493594
61MAPK150.98295423
62TAF10.97745583
63PRKCG0.97666701
64BCR0.97540956
65NEK10.95669005
66BRSK20.95580864
67AURKB0.95070431
68CDK70.91516729
69EPHB20.90021218
70FGFR10.89867085
71CSNK1A1L0.89593148
72CDK10.89030132
73RPS6KA50.85941283
74MARK10.84812333
75YES10.84452292
76CLK10.84296417
77WNK10.84187219
78NME10.82251035
79CSNK1G10.82170806
80CSNK1G20.81046128
81TRIM280.78537830
82CDK20.78462621
83CSNK1E0.78163390
84DYRK20.77525942
85CDK30.77458356
86NEK60.76710666
87SGK4940.75947693
88SGK2230.75947693
89STK110.75685915
90EIF2AK10.74002569
91AURKA0.73068452
92TLK10.72801573
93TIE10.70062423
94MUSK0.69831006
95PRKCE0.68445628
96TGFBR10.67705725
97CAMK10.67324684
98MINK10.65576132
99PRKDC0.65293180
100SCYL20.61765300
101TYRO30.60464051
102ERBB40.60131219
103NUAK10.59327691
104NTRK20.58635178
105GSK3B0.56456454
106DYRK30.56149578
107MAP2K40.55588349
108CSNK1D0.55457149
109MAPK140.54974082
110ADRBK10.54923892
111CDK180.53363363
112PRKACA0.52615203
113CDK150.52539669
114DYRK1A0.52307502
115WNK40.50932715
116SGK20.49787439
117CDK11A0.49215871
118BMPR20.48989673
119EIF2AK20.48811500
120CDK140.48353962
121CAMK1G0.48349696
122CSNK2A20.46273608
123CAMK2B0.45709222
124SGK10.45519781
125PRKACB0.45421468
126EPHA40.45199959
127ERBB30.44952674
128STK30.43127261
129CDK50.41834053
130PHKG10.41475433
131PHKG20.41475433
132MAP3K70.41432726
133CSNK1A10.41304115
134PRKCZ0.40482814
135BRSK10.40104433
136CAMK2A0.39157302
137STK40.39062378
138MAPK100.38626613
139DMPK0.38508068

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.39412770
2Mismatch repair_Homo sapiens_hsa034303.33342131
3Homologous recombination_Homo sapiens_hsa034402.92923254
4Non-homologous end-joining_Homo sapiens_hsa034502.85480209
5Phototransduction_Homo sapiens_hsa047442.74230442
6Spliceosome_Homo sapiens_hsa030402.71396122
7Cell cycle_Homo sapiens_hsa041102.64404427
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59487962
9Fanconi anemia pathway_Homo sapiens_hsa034602.50605385
10Nucleotide excision repair_Homo sapiens_hsa034202.39147414
11Basal transcription factors_Homo sapiens_hsa030222.17498066
12mRNA surveillance pathway_Homo sapiens_hsa030152.16611648
13RNA degradation_Homo sapiens_hsa030182.13434637
14RNA transport_Homo sapiens_hsa030132.12941278
15RNA polymerase_Homo sapiens_hsa030202.01611153
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97297411
17Nicotine addiction_Homo sapiens_hsa050331.95568069
18Base excision repair_Homo sapiens_hsa034101.90176567
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81640492
20Propanoate metabolism_Homo sapiens_hsa006401.81566635
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78156188
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78126617
23Protein export_Homo sapiens_hsa030601.65126748
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64456557
25Butanoate metabolism_Homo sapiens_hsa006501.63266466
26Oocyte meiosis_Homo sapiens_hsa041141.56968861
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42987586
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41117173
29Nitrogen metabolism_Homo sapiens_hsa009101.34431250
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27893457
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.27190070
32One carbon pool by folate_Homo sapiens_hsa006701.25962537
33Caffeine metabolism_Homo sapiens_hsa002321.25009983
34Folate biosynthesis_Homo sapiens_hsa007901.22818223
35GABAergic synapse_Homo sapiens_hsa047271.21903473
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21643869
37Ether lipid metabolism_Homo sapiens_hsa005651.20186225
38Alcoholism_Homo sapiens_hsa050341.19602307
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19200738
40Fatty acid elongation_Homo sapiens_hsa000621.16773298
41Selenocompound metabolism_Homo sapiens_hsa004501.16259006
42Serotonergic synapse_Homo sapiens_hsa047261.14812155
43Long-term depression_Homo sapiens_hsa047301.13346213
44Olfactory transduction_Homo sapiens_hsa047401.12712250
45Pyrimidine metabolism_Homo sapiens_hsa002401.12611348
46Morphine addiction_Homo sapiens_hsa050321.11829357
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08010255
48Dopaminergic synapse_Homo sapiens_hsa047281.07230463
49Basal cell carcinoma_Homo sapiens_hsa052171.07188670
50Hedgehog signaling pathway_Homo sapiens_hsa043401.04956323
51Glutamatergic synapse_Homo sapiens_hsa047241.04032478
52Wnt signaling pathway_Homo sapiens_hsa043101.03246215
53Oxidative phosphorylation_Homo sapiens_hsa001901.02949358
54Systemic lupus erythematosus_Homo sapiens_hsa053221.02599868
55Huntingtons disease_Homo sapiens_hsa050161.00197515
56MicroRNAs in cancer_Homo sapiens_hsa052060.99831894
57Circadian entrainment_Homo sapiens_hsa047130.95328070
58Circadian rhythm_Homo sapiens_hsa047100.95014773
59Purine metabolism_Homo sapiens_hsa002300.94223911
60Parkinsons disease_Homo sapiens_hsa050120.91142842
61Ribosome_Homo sapiens_hsa030100.90873246
62Axon guidance_Homo sapiens_hsa043600.89625352
63Amphetamine addiction_Homo sapiens_hsa050310.88794754
64Tryptophan metabolism_Homo sapiens_hsa003800.88320414
65Long-term potentiation_Homo sapiens_hsa047200.85876531
66Regulation of autophagy_Homo sapiens_hsa041400.83330998
67TGF-beta signaling pathway_Homo sapiens_hsa043500.81775470
68Taste transduction_Homo sapiens_hsa047420.79694574
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79002170
70Sulfur relay system_Homo sapiens_hsa041220.75002084
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74949283
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74339779
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73553966
74Cocaine addiction_Homo sapiens_hsa050300.73170068
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.73116688
76Peroxisome_Homo sapiens_hsa041460.72539748
77Alzheimers disease_Homo sapiens_hsa050100.72338360
78ABC transporters_Homo sapiens_hsa020100.71410658
79Proteasome_Homo sapiens_hsa030500.70476692
80Vitamin B6 metabolism_Homo sapiens_hsa007500.69026870
81Hippo signaling pathway_Homo sapiens_hsa043900.68582679
82Steroid biosynthesis_Homo sapiens_hsa001000.67783688
83Melanogenesis_Homo sapiens_hsa049160.66382469
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.65968043
85Retinol metabolism_Homo sapiens_hsa008300.65887001
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65175255
87Dorso-ventral axis formation_Homo sapiens_hsa043200.64575396
88Cholinergic synapse_Homo sapiens_hsa047250.64531908
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61249972
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60682419
91ErbB signaling pathway_Homo sapiens_hsa040120.60232041
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59011917
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58611214
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56478481
95Lysine degradation_Homo sapiens_hsa003100.54833907
96cAMP signaling pathway_Homo sapiens_hsa040240.54550921
97Thyroid cancer_Homo sapiens_hsa052160.54134696
98Notch signaling pathway_Homo sapiens_hsa043300.54032382
99Synaptic vesicle cycle_Homo sapiens_hsa047210.53952789
100beta-Alanine metabolism_Homo sapiens_hsa004100.53933059
101Prostate cancer_Homo sapiens_hsa052150.53923649
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53619626
103Viral carcinogenesis_Homo sapiens_hsa052030.51385082
104Renal cell carcinoma_Homo sapiens_hsa052110.50574036
105Colorectal cancer_Homo sapiens_hsa052100.50294699
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50232104
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48902394
108Epstein-Barr virus infection_Homo sapiens_hsa051690.47589553
109MAPK signaling pathway_Homo sapiens_hsa040100.47144476
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46743262
111Metabolic pathways_Homo sapiens_hsa011000.46742699
112Pathways in cancer_Homo sapiens_hsa052000.46659396
113HTLV-I infection_Homo sapiens_hsa051660.46032908
114Chemical carcinogenesis_Homo sapiens_hsa052040.45176477
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45024104
116Oxytocin signaling pathway_Homo sapiens_hsa049210.43379270
117Insulin secretion_Homo sapiens_hsa049110.43087618
118Vitamin digestion and absorption_Homo sapiens_hsa049770.41121257
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39370511
120p53 signaling pathway_Homo sapiens_hsa041150.38402962
121Gap junction_Homo sapiens_hsa045400.36606965
122Ovarian steroidogenesis_Homo sapiens_hsa049130.35813594
123Inositol phosphate metabolism_Homo sapiens_hsa005620.35428332
124Melanoma_Homo sapiens_hsa052180.34079976
125Non-small cell lung cancer_Homo sapiens_hsa052230.33929356
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33152400
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31958686
128Ras signaling pathway_Homo sapiens_hsa040140.30994766
129Tight junction_Homo sapiens_hsa045300.30302593
130Thyroid hormone synthesis_Homo sapiens_hsa049180.29854857
131Linoleic acid metabolism_Homo sapiens_hsa005910.29277565
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.28289166
133Cardiac muscle contraction_Homo sapiens_hsa042600.28247033
134Calcium signaling pathway_Homo sapiens_hsa040200.27884232
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27383973
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26746547
137Salivary secretion_Homo sapiens_hsa049700.26011978
138Bladder cancer_Homo sapiens_hsa052190.25415161

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