ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	9.85072279
2	chromosome organization involved in meiosis (GO:0070192)	9.84745608
3	male meiosis (GO:0007140)	9.58516300
4	synaptonemal complex assembly (GO:0007130)	9.03436185
5	DNA methylation involved in gamete generation (GO:0043046)	8.79984887
6	synaptonemal complex organization (GO:0070193)	8.19942808
7	gonadal mesoderm development (GO:0007506)	8.15823922
8	meiosis I (GO:0007127)	7.97230145
9	meiotic nuclear division (GO:0007126)	7.81163371
10	resolution of meiotic recombination intermediates (GO:0000712)	7.11326113
11	positive regulation of meiosis (GO:0045836)	7.07982662
12	positive regulation of meiotic cell cycle (GO:0051446)	6.63586359
13	meiotic cell cycle process (GO:1903046)	6.59967830
14	DNA synthesis involved in DNA repair (GO:0000731)	6.00114954
15	gene silencing by RNA (GO:0031047)	5.84695458
16	sister chromatid cohesion (GO:0007062)	5.66884176
17	meiotic chromosome segregation (GO:0045132)	5.34009826
18	oogenesis (GO:0048477)	5.22075465
19	histone H3-K9 demethylation (GO:0033169)	5.08907895
20	negative regulation of meiosis (GO:0045835)	4.87687520
21	mitotic chromosome condensation (GO:0007076)	4.87424758
22	female gamete generation (GO:0007292)	4.83956980
23	acrosome reaction (GO:0007340)	4.76495430
24	regulation of meiotic cell cycle (GO:0051445)	4.74356607
25	regulation of meiosis (GO:0040020)	4.72760072
26	spermatid development (GO:0007286)	4.62568130
27	meiotic cell cycle (GO:0051321)	4.61993289
28	binding of sperm to zona pellucida (GO:0007339)	4.49086726
29	fusion of sperm to egg plasma membrane (GO:0007342)	4.37221590
30	regulation of histone H3-K9 methylation (GO:0051570)	4.18685976
31	germ cell development (GO:0007281)	4.16830227
32	centriole replication (GO:0007099)	4.10394562
33	mitotic sister chromatid cohesion (GO:0007064)	4.00061113
34	DNA packaging (GO:0006323)	3.84529973
35	chromosome condensation (GO:0030261)	3.83265170
36	fertilization (GO:0009566)	3.78397461
37	histone exchange (GO:0043486)	3.77994817
38	oocyte maturation (GO:0001556)	3.76781045
39	gene silencing (GO:0016458)	3.75923902
40	sperm-egg recognition (GO:0035036)	3.75027636
41	reciprocal DNA recombination (GO:0035825)	3.69767113
42	reciprocal meiotic recombination (GO:0007131)	3.69767113
43	mitotic metaphase plate congression (GO:0007080)	3.58307849
44	male gamete generation (GO:0048232)	3.55037986
45	spermatogenesis (GO:0007283)	3.54471360
46	DNA methylation (GO:0006306)	3.50950388
47	DNA alkylation (GO:0006305)	3.50950388
48	gamete generation (GO:0007276)	3.42269845
49	microtubule depolymerization (GO:0007019)	3.41617261
50	attachment of spindle microtubules to kinetochore (GO:0008608)	3.39020941
51	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.36383091
52	negative regulation of meiotic cell cycle (GO:0051447)	3.33627683
53	regulation of DNA endoreduplication (GO:0032875)	3.32716288
54	sperm motility (GO:0030317)	3.31862637
55	sex differentiation (GO:0007548)	3.29602397
56	negative regulation of gene silencing (GO:0060969)	3.27169528
57	plasma membrane fusion (GO:0045026)	3.26967762
58	centriole assembly (GO:0098534)	3.24265970
59	CENP-A containing nucleosome assembly (GO:0034080)	3.20759202
60	metaphase plate congression (GO:0051310)	3.19031708
61	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.18747282
62	positive regulation of translational initiation (GO:0045948)	3.17870740
63	oocyte development (GO:0048599)	3.11350185
64	microtubule severing (GO:0051013)	3.10777538
65	chromatin remodeling at centromere (GO:0031055)	3.06083526
66	nuclear pore complex assembly (GO:0051292)	3.04559794
67	seminiferous tubule development (GO:0072520)	3.01919915
68	chromosome organization (GO:0051276)	2.98534607
69	interkinetic nuclear migration (GO:0022027)	2.94908267
70	protein targeting to Golgi (GO:0000042)	2.94628384
71	regulation of chromosome segregation (GO:0051983)	2.92166924
72	cell-cell recognition (GO:0009988)	2.90600366
73	establishment of protein localization to Golgi (GO:0072600)	2.88953746
74	protein K6-linked ubiquitination (GO:0085020)	2.88701272
75	lymphangiogenesis (GO:0001946)	2.87197271
76	nuclear division (GO:0000280)	2.87094491
77	embryonic foregut morphogenesis (GO:0048617)	2.81629525
78	mitotic spindle assembly checkpoint (GO:0007094)	2.78191025
79	metanephric mesenchyme development (GO:0072075)	2.76556773
80	mitotic spindle checkpoint (GO:0071174)	2.75549863
81	embryonic body morphogenesis (GO:0010172)	2.75431521
82	proteasome assembly (GO:0043248)	2.74965155
83	microtubule polymerization or depolymerization (GO:0031109)	2.72335299
84	organelle fission (GO:0048285)	2.72060935
85	spindle assembly checkpoint (GO:0071173)	2.71341691
86	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.69679905
87	multicellular organismal reproductive process (GO:0048609)	2.69402959
88	negative regulation of nuclear division (GO:0051784)	2.66469428
89	DNA catabolic process, exonucleolytic (GO:0000738)	2.65434832
90	regulation of centriole replication (GO:0046599)	2.63899145
91	histone H4-K12 acetylation (GO:0043983)	2.63316015
92	nuclear pore organization (GO:0006999)	2.62363598
93	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.61424233
94	negative regulation of sister chromatid segregation (GO:0033046)	2.61424233
95	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.61424233
96	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.61424233
97	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.61424233
98	piRNA metabolic process (GO:0034587)	14.1291527
99	synapsis (GO:0007129)	12.2188543
100	regulation of meiosis I (GO:0060631)	10.5349869

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.75467101
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	6.22767670
3	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	4.57334592
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	4.57334592
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	4.57334592
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.50805977
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.87438434
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70739882
9	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.61103247
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.37795439
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.09900067
12	* ZNF274_21170338_ChIP-Seq_K562_Hela	2.08956538
13	FUS_26573619_Chip-Seq_HEK293_Human	2.07991657
14	RNF2_27304074_Chip-Seq_NSC_Mouse	2.06151809
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.04114501
16	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.01894846
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.96262325
18	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.92193080
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.86717125
20	VDR_22108803_ChIP-Seq_LS180_Human	1.76238976
21	* IGF1R_20145208_ChIP-Seq_DFB_Human	1.75291173
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.65937859
23	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.56129713
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.54658820
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53531329
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53078734
27	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.45727324
28	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.43284193
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.42801201
30	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38978636
31	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.37445442
32	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.36942202
33	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.35457043
34	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32874275
35	* STAT3_23295773_ChIP-Seq_U87_Human	1.31514112
36	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.31505857
37	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.31031689
38	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.29265875
39	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.28886767
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.28467750
41	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27848400
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.23302535
43	EWS_26573619_Chip-Seq_HEK293_Human	1.21350091
44	HTT_18923047_ChIP-ChIP_STHdh_Human	1.20817922
45	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.19654136
46	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.19441084
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18528495
48	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.18024662
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17223935
50	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.15081090
51	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.12869789
52	P300_19829295_ChIP-Seq_ESCs_Human	1.12159282
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12148322
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12148322
55	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11710553
56	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11682625
57	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.11026052
58	DCP1A_22483619_ChIP-Seq_HELA_Human	1.11004897
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10144194
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.08628535
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08628535
62	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06650505
63	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06040865
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02433633
65	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02173464
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.01723915
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01656469
68	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.00471402
69	* ER_23166858_ChIP-Seq_MCF-7_Human	1.00440841
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00311769
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00311769
72	* GATA3_26560356_Chip-Seq_TH1_Human	0.99940950
73	* BCAT_22108803_ChIP-Seq_LS180_Human	0.99896164
74	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.99401253
75	GBX2_23144817_ChIP-Seq_PC3_Human	0.98690442
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98121320
77	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.97006977
78	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95280965
79	ETV1_20927104_ChIP-Seq_GIST48_Human	0.94138750
80	* TCF4_23295773_ChIP-Seq_U87_Human	0.92562242
81	* AR_25329375_ChIP-Seq_VCAP_Human	0.92482521
82	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.91037657
83	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.89422895
84	VDR_23849224_ChIP-Seq_CD4+_Human	0.89273437
85	* SMAD3_21741376_ChIP-Seq_EPCs_Human	0.89027991
86	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.88035355
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.85574185
88	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.85181006
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.84801287
90	SMAD4_21799915_ChIP-Seq_A2780_Human	0.84595860
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81831375
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.81307948
93	TP53_22573176_ChIP-Seq_HFKS_Human	0.80612546
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.80082046
95	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.79662458
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.79032944
97	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.78873817
98	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.78396088
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.78324639
100	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.77971250

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	8.13025753
2	MP0010368_abnormal_lymphatic_system	4.54539820
3	MP0002210_abnormal_sex_determination	4.36082125
4	MP0001929_abnormal_gametogenesis	4.18173909
5	MP0003698_abnormal_male_reproductive	3.45789037
6	MP0001145_abnormal_male_reproductive	3.33169308
7	MP0008058_abnormal_DNA_repair	3.30696620
8	MP0005410_abnormal_fertilization	3.24907869
9	MP0000653_abnormal_sex_gland	3.19773702
10	MP0010030_abnormal_orbit_morphology	3.18914131
11	MP0003183_abnormal_peptide_metabolism	2.71209823
12	MP0003693_abnormal_embryo_hatching	2.46029045
13	MP0003718_maternal_effect	2.37493799
14	MP0001879_abnormal_lymphatic_vessel	2.21066944
15	MP0008789_abnormal_olfactory_epithelium	2.14248008
16	MP0002161_abnormal_fertility/fecundity	2.09706632
17	MP0002160_abnormal_reproductive_system	2.07248615
18	MP0000678_abnormal_parathyroid_gland	1.99651938
19	MP0000569_abnormal_digit_pigmentation	1.97039941
20	MP0010094_abnormal_chromosome_stability	1.89782149
21	MP0001188_hyperpigmentation	1.85367629
22	MP0001119_abnormal_female_reproductive	1.76447683
23	MP0005174_abnormal_tail_pigmentation	1.75947054
24	MP0003077_abnormal_cell_cycle	1.75185624
25	MP0004957_abnormal_blastocyst_morpholog	1.73452795
26	MP0008057_abnormal_DNA_replication	1.71627075
27	MP0003646_muscle_fatigue	1.60974737
28	MP0005503_abnormal_tendon_morphology	1.51605832
29	MP0003111_abnormal_nucleus_morphology	1.50169859
30	MP0005670_abnormal_white_adipose	1.49222005
31	MP0003699_abnormal_female_reproductive	1.44277994
32	MP0001177_atelectasis	1.42231698
33	MP0003119_abnormal_digestive_system	1.39181520
34	MP0001730_embryonic_growth_arrest	1.28289777
35	MP0002932_abnormal_joint_morphology	1.16969021
36	MP0010307_abnormal_tumor_latency	1.16663842
37	MP0000049_abnormal_middle_ear	1.14489188
38	MP0008932_abnormal_embryonic_tissue	1.13806138
39	MP0002233_abnormal_nose_morphology	1.12474786
40	MP0003385_abnormal_body_wall	1.09179921
41	MP0006292_abnormal_olfactory_placode	1.08023126
42	MP0008260_abnormal_autophagy	1.06811197
43	MP0004147_increased_porphyrin_level	1.04193973
44	MP0000733_abnormal_muscle_development	1.03185709
45	MP0009250_abnormal_appendicular_skeleto	1.00932015
46	MP0002114_abnormal_axial_skeleton	0.96758388
47	MP0005389_reproductive_system_phenotype	0.96223933
48	MP0002085_abnormal_embryonic_tissue	0.96001037
49	MP0000462_abnormal_digestive_system	0.95310215
50	MP0002084_abnormal_developmental_patter	0.94347316
51	MP0003936_abnormal_reproductive_system	0.91847456
52	MP0005058_abnormal_lysosome_morphology	0.90535415
53	MP0001485_abnormal_pinna_reflex	0.88809525
54	MP0008007_abnormal_cellular_replicative	0.88134948
55	MP0003935_abnormal_craniofacial_develop	0.87747835
56	MP0008004_abnormal_stomach_pH	0.87114706
57	MP0005409_darkened_coat_color	0.86959169
58	MP0003567_abnormal_fetal_cardiomyocyte	0.83936573
59	MP0003755_abnormal_palate_morphology	0.80989465
60	MP0002116_abnormal_craniofacial_bone	0.80376741
61	MP0003186_abnormal_redox_activity	0.79081770
62	MP0005380_embryogenesis_phenotype	0.78628616
63	MP0001672_abnormal_embryogenesis/_devel	0.78628616
64	MP0003879_abnormal_hair_cell	0.77472164
65	MP0001299_abnormal_eye_distance/	0.77152497
66	MP0003937_abnormal_limbs/digits/tail_de	0.75186505
67	MP0009053_abnormal_anal_canal	0.74314662
68	MP0002109_abnormal_limb_morphology	0.72641717
69	MP0005395_other_phenotype	0.71424920
70	MP0002108_abnormal_muscle_morphology	0.70998352
71	MP0002249_abnormal_larynx_morphology	0.68901536
72	MP0003115_abnormal_respiratory_system	0.68039294
73	MP0000350_abnormal_cell_proliferation	0.66818418
74	MP0003136_yellow_coat_color	0.66709819
75	MP0001963_abnormal_hearing_physiology	0.66007532
76	MP0002080_prenatal_lethality	0.64426584
77	MP0004197_abnormal_fetal_growth/weight/	0.64109068
78	MP0000358_abnormal_cell_content/	0.63708511
79	MP0005499_abnormal_olfactory_system	0.63130413
80	MP0005394_taste/olfaction_phenotype	0.63130413
81	MP0000015_abnormal_ear_pigmentation	0.62975168
82	MP0004233_abnormal_muscle_weight	0.61938568
83	MP0003861_abnormal_nervous_system	0.60508937
84	MP0000026_abnormal_inner_ear	0.58397579
85	MP0000313_abnormal_cell_death	0.58239645
86	MP0004215_abnormal_myocardial_fiber	0.58056483
87	MP0000432_abnormal_head_morphology	0.57205510
88	MP0002177_abnormal_outer_ear	0.56359121
89	MP0001697_abnormal_embryo_size	0.55813124
90	MP0001270_distended_abdomen	0.55653106
91	MP0005377_hearing/vestibular/ear_phenot	0.55255427
92	MP0003878_abnormal_ear_physiology	0.55255427
93	MP0004133_heterotaxia	0.54423400
94	MP0001346_abnormal_lacrimal_gland	0.52291295
95	MP0005647_abnormal_sex_gland	0.50665391
96	MP0006035_abnormal_mitochondrial_morpho	0.49538057
97	MP0003943_abnormal_hepatobiliary_system	0.48669254
98	MP0001502_abnormal_circadian_rhythm	0.48477494
99	MP0000762_abnormal_tongue_morphology	0.48044197
100	MP0000534_abnormal_ureter_morphology	0.47072122

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gonadotropin excess (HP:0000837)	5.29241345
2	Scotoma (HP:0000575)	4.69795837
3	Osteomalacia (HP:0002749)	4.64486913
4	Tubulointerstitial nephritis (HP:0001970)	4.42614257
5	Delayed epiphyseal ossification (HP:0002663)	4.39632612
6	Enlarged epiphyses (HP:0010580)	4.20939601
7	Lip pit (HP:0100267)	4.13645408
8	Abnormality of the costochondral junction (HP:0000919)	4.04498078
9	Volvulus (HP:0002580)	4.01887337
10	Thin bony cortex (HP:0002753)	3.94099204
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.88372429
12	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.80139032
13	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.80139032
14	Chromsome breakage (HP:0040012)	3.79663556
15	Azoospermia (HP:0000027)	3.61186666
16	Horizontal nystagmus (HP:0000666)	3.39182023
17	Abnormality of the corticospinal tract (HP:0002492)	3.29418366
18	Ectopic kidney (HP:0000086)	3.23910196
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.14284889
20	Absent/shortened dynein arms (HP:0200106)	3.14284889
21	Abnormal spermatogenesis (HP:0008669)	2.96634290
22	Abnormality of DNA repair (HP:0003254)	2.93210505
23	Median cleft lip (HP:0000161)	2.76948872
24	Male infertility (HP:0003251)	2.73160079
25	Septate vagina (HP:0001153)	2.65778993
26	Supernumerary spleens (HP:0009799)	2.62734013
27	Truncal obesity (HP:0001956)	2.60936555
28	Spontaneous abortion (HP:0005268)	2.58188140
29	Oligodactyly (hands) (HP:0001180)	2.51320547
30	Small intestinal stenosis (HP:0012848)	2.51030775
31	Duodenal stenosis (HP:0100867)	2.51030775
32	Vertebral arch anomaly (HP:0008438)	2.49741691
33	Rickets (HP:0002748)	2.48314061
34	Abnormal lung lobation (HP:0002101)	2.47902059
35	Widely patent fontanelles and sutures (HP:0004492)	2.45384598
36	Abnormality of the renal collecting system (HP:0004742)	2.43715117
37	Broad distal phalanx of finger (HP:0009836)	2.43257312
38	Metaphyseal irregularity (HP:0003025)	2.40246863
39	Shoulder girdle muscle weakness (HP:0003547)	2.37330003
40	Increased nuchal translucency (HP:0010880)	2.25524115
41	Capillary hemangiomas (HP:0005306)	2.24651963
42	Abnormal ciliary motility (HP:0012262)	2.23917754
43	Nephronophthisis (HP:0000090)	2.22752925
44	Tubulointerstitial abnormality (HP:0001969)	2.18653585
45	Horseshoe kidney (HP:0000085)	2.15151480
46	Hypergonadotropic hypogonadism (HP:0000815)	2.14320952
47	Hypophosphatemic rickets (HP:0004912)	2.12172025
48	Metaphyseal cupping (HP:0003021)	2.08784274
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08745822
50	Impaired vibration sensation in the lower limbs (HP:0002166)	2.08522063
51	Infertility (HP:0000789)	2.07332576
52	Short tibia (HP:0005736)	2.07283253
53	Abnormal auditory evoked potentials (HP:0006958)	2.04838632
54	Central scotoma (HP:0000603)	2.02926780
55	Facial hemangioma (HP:0000329)	2.02440000
56	Retinal dysplasia (HP:0007973)	1.99577979
57	Abnormality of chromosome segregation (HP:0002916)	1.98687901
58	Abnormality of the duodenum (HP:0002246)	1.91713086
59	Heterotopia (HP:0002282)	1.91073190
60	Bell-shaped thorax (HP:0001591)	1.90121089
61	Abnormality of the phalanges of the hallux (HP:0010057)	1.89274175
62	Abnormality of the renal medulla (HP:0100957)	1.88598290
63	Anterior segment dysgenesis (HP:0007700)	1.88006899
64	Anteriorly placed anus (HP:0001545)	1.87537807
65	Midline defect of the nose (HP:0004122)	1.86473486
66	Absent radius (HP:0003974)	1.85895465
67	Oligodactyly (HP:0012165)	1.84682663
68	Chronic hepatic failure (HP:0100626)	1.84540878
69	Duplicated collecting system (HP:0000081)	1.81390236
70	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.80915889
71	Microglossia (HP:0000171)	1.80316785
72	Leiomyosarcoma (HP:0100243)	1.79522508
73	Uterine leiomyosarcoma (HP:0002891)	1.79522508
74	Abnormality of lateral ventricle (HP:0030047)	1.79169392
75	Flat occiput (HP:0005469)	1.78376670
76	Rhabdomyosarcoma (HP:0002859)	1.77040522
77	Abnormality of midbrain morphology (HP:0002418)	1.75784207
78	Molar tooth sign on MRI (HP:0002419)	1.75784207
79	Abnormal respiratory motile cilium physiology (HP:0012261)	1.74182687
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73220126
81	Wide cranial sutures (HP:0010537)	1.72319644
82	Genetic anticipation (HP:0003743)	1.72112895
83	Reticulocytopenia (HP:0001896)	1.71525314
84	Rectovaginal fistula (HP:0000143)	1.71094637
85	Rectal fistula (HP:0100590)	1.71094637
86	Proximal tubulopathy (HP:0000114)	1.70312975
87	Astigmatism (HP:0000483)	1.70078953
88	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.69509608
89	Aplasia involving forearm bones (HP:0009822)	1.69449311
90	Absent forearm bone (HP:0003953)	1.69449311
91	Poikiloderma (HP:0001029)	1.68920880
92	Abnormality of chromosome stability (HP:0003220)	1.66036790
93	Proximal placement of thumb (HP:0009623)	1.64883498
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.64841672
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.64841672
96	Impulsivity (HP:0100710)	1.64616598
97	Neoplasm of the oral cavity (HP:0100649)	1.63719758
98	Severe visual impairment (HP:0001141)	1.63444278
99	Non-midline cleft lip (HP:0100335)	1.62745237
100	Menstrual irregularities (HP:0000858)	1.62695851

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	5.84639296
2	ACVR1B	5.63384129
3	PNCK	5.62910903
4	PLK4	3.78555210
5	TTK	3.21385349
6	CDK12	2.61406891
7	WNK1	2.33466629
8	STK38L	2.25101184
9	KSR2	2.19177203
10	MAP3K2	2.16709494
11	BRAF	2.13997037
12	NTRK3	2.01307981
13	MET	1.96034961
14	NEK9	1.92221996
15	STK39	1.81893435
16	STK24	1.73379154
17	MST1R	1.69485983
18	WNK4	1.67316880
19	PLK1	1.59400740
20	STK38	1.51713589
21	TYRO3	1.51534521
22	BRD4	1.39828212
23	WEE1	1.36608213
24	STK16	1.27965118
25	STK3	1.26690180
26	NEK6	1.24714645
27	CDC7	1.16014623
28	RAF1	1.11793062
29	ZAK	1.11093676
30	KSR1	1.10694913
31	AURKA	1.05388472
32	PBK	1.05375873
33	CAMK1G	1.04157754
34	CHEK1	0.96411920
35	BMPR1B	0.96345574
36	PLK2	0.89484407
37	CLK1	0.89341192
38	DDR2	0.88974130
39	BRSK1	0.88674911
40	PIK3CG	0.87567372
41	CDK7	0.86514290
42	EIF2AK3	0.84941504
43	MAP3K1	0.81608142
44	MAP3K13	0.80716419
45	PTK2B	0.78898228
46	ATR	0.77450087
47	NEK2	0.74401483
48	MATK	0.74315537
49	MAP3K8	0.71257030
50	CDK3	0.71113719
51	BUB1	0.70051211
52	DYRK1A	0.67140812
53	CHEK2	0.66045149
54	KIT	0.64517456
55	OXSR1	0.63194226
56	ATM	0.62648909
57	MAP3K12	0.61120376
58	CDK9	0.59820611
59	MAP3K4	0.58973069
60	CDK8	0.58324803
61	PASK	0.57822863
62	PINK1	0.56182942
63	PDK2	0.53530193
64	CDK4	0.51993670
65	INSRR	0.50314252
66	BRSK2	0.48456847
67	SCYL2	0.48116034
68	MOS	0.47939883
69	ARAF	0.46382937
70	CDK2	0.46271238
71	PRKCI	0.46175768
72	MKNK2	0.45947133
73	CDK1	0.44242084
74	MAP3K9	0.44129164
75	MARK3	0.43653223
76	EPHA4	0.41976949
77	LATS1	0.41670324
78	CDK11A	0.41143297
79	PRKG1	0.39074631
80	PTK2	0.38588159
81	SGK1	0.37457426
82	RPS6KB1	0.36408563
83	RET	0.35294343
84	ERBB3	0.34052116
85	PDGFRA	0.33971943
86	DYRK3	0.33732369
87	AURKB	0.33049344
88	ERBB4	0.31765527
89	GRK1	0.28872800
90	PRKACB	0.27687501
91	PDGFRB	0.27318065
92	MELK	0.26061680
93	FGFR3	0.25969187
94	PLK3	0.25567815
95	TESK1	0.25276966
96	MAPK1	0.24950963
97	TAOK3	0.23773546
98	CCNB1	0.21913536
99	MTOR	0.21516120
100	RPS6KC1	0.21508772

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Dorso-ventral axis formation_Homo sapiens_hsa04320	4.16992475
2	Mismatch repair_Homo sapiens_hsa03430	3.74857854
3	Cell cycle_Homo sapiens_hsa04110	3.67823387
4	Basal transcription factors_Homo sapiens_hsa03022	3.42348653
5	Homologous recombination_Homo sapiens_hsa03440	3.27183608
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.98221539
7	DNA replication_Homo sapiens_hsa03030	2.96948201
8	RNA transport_Homo sapiens_hsa03013	2.95679713
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.94680175
10	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.92610801
11	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	2.87394047
12	Oocyte meiosis_Homo sapiens_hsa04114	2.87040300
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.76793424
14	Base excision repair_Homo sapiens_hsa03410	2.66314213
15	mRNA surveillance pathway_Homo sapiens_hsa03015	2.00773715
16	Regulation of autophagy_Homo sapiens_hsa04140	1.95681718
17	p53 signaling pathway_Homo sapiens_hsa04115	1.87001934
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.67985463
19	Sulfur relay system_Homo sapiens_hsa04122	1.58268186
20	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.54067589
21	RNA degradation_Homo sapiens_hsa03018	1.33249723
22	ABC transporters_Homo sapiens_hsa02010	1.30246330
23	Olfactory transduction_Homo sapiens_hsa04740	1.28853399
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25357495
25	Wnt signaling pathway_Homo sapiens_hsa04310	1.23041721
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.21948523
27	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.19109467
28	Folate biosynthesis_Homo sapiens_hsa00790	1.11013721
29	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.10381753
30	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.09856319
31	mTOR signaling pathway_Homo sapiens_hsa04150	1.07485310
32	Propanoate metabolism_Homo sapiens_hsa00640	1.01628062
33	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.96639936
34	Steroid biosynthesis_Homo sapiens_hsa00100	0.94113217
35	Circadian rhythm_Homo sapiens_hsa04710	0.93382463
36	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.86439610
37	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.84952760
38	RNA polymerase_Homo sapiens_hsa03020	0.77109269
39	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.76268021
40	HTLV-I infection_Homo sapiens_hsa05166	0.75886691
41	ErbB signaling pathway_Homo sapiens_hsa04012	0.74317791
42	Type II diabetes mellitus_Homo sapiens_hsa04930	0.66191400
43	Purine metabolism_Homo sapiens_hsa00230	0.64998112
44	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.64480045
45	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.64415733
46	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.63628973
47	Lysine degradation_Homo sapiens_hsa00310	0.61849557
48	Notch signaling pathway_Homo sapiens_hsa04330	0.61565093
49	Fatty acid degradation_Homo sapiens_hsa00071	0.61427471
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58686905
51	Calcium signaling pathway_Homo sapiens_hsa04020	0.55817759
52	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54245776
53	Gap junction_Homo sapiens_hsa04540	0.53828883
54	Protein digestion and absorption_Homo sapiens_hsa04974	0.52085542
55	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.49682524
56	Phototransduction_Homo sapiens_hsa04744	0.48623894
57	Hippo signaling pathway_Homo sapiens_hsa04390	0.46142268
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.45950395
59	Endocytosis_Homo sapiens_hsa04144	0.45853086
60	Small cell lung cancer_Homo sapiens_hsa05222	0.45055626
61	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.44314734
62	Fatty acid elongation_Homo sapiens_hsa00062	0.43764799
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.40739811
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.40699725
65	FoxO signaling pathway_Homo sapiens_hsa04068	0.38731950
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37543297
67	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.37292517
68	Choline metabolism in cancer_Homo sapiens_hsa05231	0.36320745
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.35334162
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33701927
71	ECM-receptor interaction_Homo sapiens_hsa04512	0.33136497
72	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.32891006
73	MicroRNAs in cancer_Homo sapiens_hsa05206	0.32665888
74	Colorectal cancer_Homo sapiens_hsa05210	0.32138359
75	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.31139071
76	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30745841
77	Melanoma_Homo sapiens_hsa05218	0.30442084
78	Acute myeloid leukemia_Homo sapiens_hsa05221	0.30214499
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.29414753
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27711241
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.27408068
82	Pathways in cancer_Homo sapiens_hsa05200	0.27243322
83	Ribosome_Homo sapiens_hsa03010	0.27210334
84	Taste transduction_Homo sapiens_hsa04742	0.26521425
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26305552
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.25253121
87	Spliceosome_Homo sapiens_hsa03040	0.25127467
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.24957396
89	Retinol metabolism_Homo sapiens_hsa00830	0.24256221
90	Prion diseases_Homo sapiens_hsa05020	0.22586388
91	Viral carcinogenesis_Homo sapiens_hsa05203	0.22021640
92	Long-term depression_Homo sapiens_hsa04730	0.21286812
93	Proteoglycans in cancer_Homo sapiens_hsa05205	0.20609679
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20043819
95	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.19898646
96	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.19189717
97	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.19065566
98	Nicotine addiction_Homo sapiens_hsa05033	0.18656579
99	Estrogen signaling pathway_Homo sapiens_hsa04915	0.18176517
100	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.16715454

ANKRD26P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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