ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptonemal complex assembly (GO:0007130)	8.85498048
2	chromosome organization involved in meiosis (GO:0070192)	8.51140166
3	synaptonemal complex organization (GO:0070193)	7.96030188
4	synapsis (GO:0007129)	7.95411633
5	male meiosis I (GO:0007141)	6.84220583
6	piRNA metabolic process (GO:0034587)	6.47649318
7	meiosis I (GO:0007127)	5.88365449
8	male meiosis (GO:0007140)	5.86389803
9	negative regulation of mast cell activation (GO:0033004)	5.04410790
10	DNA methylation involved in gamete generation (GO:0043046)	5.02987375
11	DNA synthesis involved in DNA repair (GO:0000731)	5.01535736
12	mature B cell differentiation involved in immune response (GO:0002313)	4.96351857
13	meiotic nuclear division (GO:0007126)	4.93308447
14	vitamin catabolic process (GO:0009111)	4.89798381
15	fat-soluble vitamin catabolic process (GO:0042363)	4.89798381
16	polarized epithelial cell differentiation (GO:0030859)	4.88741444
17	meiotic cell cycle process (GO:1903046)	4.63709303
18	mature B cell differentiation (GO:0002335)	4.28186020
19	reciprocal DNA recombination (GO:0035825)	4.21213455
20	reciprocal meiotic recombination (GO:0007131)	4.21213455
21	regulation of female receptivity (GO:0045924)	4.18417923
22	respiratory tube development (GO:0030323)	4.01192673
23	sister chromatid cohesion (GO:0007062)	3.91056641
24	regulation of inositol phosphate biosynthetic process (GO:0010919)	3.73868919
25	B cell receptor signaling pathway (GO:0050853)	3.69443849
26	female mating behavior (GO:0060180)	3.67050425
27	regulation of B cell receptor signaling pathway (GO:0050855)	3.66299355
28	meiotic chromosome segregation (GO:0045132)	3.65537473
29	regulation of macrophage chemotaxis (GO:0010758)	3.63761846
30	regulation of meiosis I (GO:0060631)	3.61040283
31	protein polyglutamylation (GO:0018095)	3.53849305
32	sperm motility (GO:0030317)	3.47477701
33	lung vasculature development (GO:0060426)	3.44896705
34	interkinetic nuclear migration (GO:0022027)	3.43619260
35	spermatid development (GO:0007286)	3.39243485
36	histone H3-K9 demethylation (GO:0033169)	3.36941036
37	DNA packaging (GO:0006323)	3.29197769
38	cardiac left ventricle morphogenesis (GO:0003214)	3.28275357
39	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.23417629
40	establishment of apical/basal cell polarity (GO:0035089)	3.20857825
41	T cell migration (GO:0072678)	3.20137757
42	rRNA methylation (GO:0031167)	3.13301765
43	positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)	3.12736990
44	histone exchange (GO:0043486)	3.12110035
45	single strand break repair (GO:0000012)	3.09399122
46	establishment of protein localization to Golgi (GO:0072600)	3.08540872
47	acrosome reaction (GO:0007340)	3.08315538
48	establishment of epithelial cell polarity (GO:0090162)	3.06585823
49	rRNA modification (GO:0000154)	3.02185122
50	protein targeting to Golgi (GO:0000042)	3.01533130
51	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.97120719
52	DNA deamination (GO:0045006)	2.93413160
53	regulation of DNA endoreduplication (GO:0032875)	2.93230286
54	regulation of histone H3-K9 methylation (GO:0051570)	2.87746533
55	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.85003808
56	negative regulation of B cell proliferation (GO:0030889)	2.83845042
57	mast cell degranulation (GO:0043303)	2.81667321
58	mast cell activation involved in immune response (GO:0002279)	2.81667321
59	microtubule depolymerization (GO:0007019)	2.78724148
60	chromosome condensation (GO:0030261)	2.78610528
61	positive regulation of B cell differentiation (GO:0045579)	2.72426009
62	multicellular organism reproduction (GO:0032504)	2.67974040
63	urinary tract smooth muscle contraction (GO:0014848)	2.63999509
64	phosphatidylethanolamine metabolic process (GO:0046337)	2.62573111
65	sperm-egg recognition (GO:0035036)	2.61648159
66	spermatogenesis (GO:0007283)	2.61164328
67	male gamete generation (GO:0048232)	2.60905365
68	positive regulation of response to oxidative stress (GO:1902884)	2.59630127
69	positive regulation of cellular response to oxidative stress (GO:1900409)	2.59630127
70	regulation of establishment of cell polarity (GO:2000114)	2.56861115
71	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.56609525
72	establishment of monopolar cell polarity (GO:0061162)	2.56609525
73	lung lobe morphogenesis (GO:0060463)	2.55177477
74	monoubiquitinated protein deubiquitination (GO:0035520)	2.54218607
75	gamete generation (GO:0007276)	2.54127652
76	regulation of transcription from RNA polymerase I promoter (GO:0006356)	2.54060617
77	resolution of meiotic recombination intermediates (GO:0000712)	2.53190040
78	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.52799668
79	negative regulation of viral release from host cell (GO:1902187)	2.51772640
80	gene silencing by RNA (GO:0031047)	2.51072166
81	chromosome organization (GO:0051276)	2.50633817
82	B cell homeostasis (GO:0001782)	2.50558013
83	fertilization (GO:0009566)	2.50529815
84	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.50501662
85	neuronal action potential (GO:0019228)	2.48677752
86	DNA alkylation (GO:0006305)	2.47126582
87	DNA methylation (GO:0006306)	2.47126582
88	positive regulation of meiosis (GO:0045836)	2.46869541
89	regulation of somitogenesis (GO:0014807)	2.46656251
90	B cell activation involved in immune response (GO:0002312)	2.44808304
91	NAD biosynthetic process (GO:0009435)	2.44551988
92	regulation of germinal center formation (GO:0002634)	2.44271552
93	detection of light stimulus involved in visual perception (GO:0050908)	2.43275940
94	detection of light stimulus involved in sensory perception (GO:0050962)	2.43275940
95	positive regulation of cAMP-mediated signaling (GO:0043950)	2.43270954
96	negative regulation of inclusion body assembly (GO:0090084)	2.41108842
97	binding of sperm to zona pellucida (GO:0007339)	2.38161302
98	mitotic G1/S transition checkpoint (GO:0044819)	2.36891830
99	skeletal muscle tissue regeneration (GO:0043403)	2.36639702
100	centriole replication (GO:0007099)	2.36376441

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.05433304
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.86215725
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.68375232
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.57401278
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.49509123
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.21565268
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.63830629
8	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.47912855
9	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.08095727
10	FUS_26573619_Chip-Seq_HEK293_Human	2.04076638
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.00473511
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96160777
13	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94332100
14	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.94332100
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91617777
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90857992
17	EWS_26573619_Chip-Seq_HEK293_Human	1.90158905
18	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.87763501
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69716333
20	VDR_22108803_ChIP-Seq_LS180_Human	1.68889457
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.64035032
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.63710044
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57152040
24	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.53259894
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53048519
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.51014182
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49256810
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.49256810
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.48575252
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45300461
31	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.45087163
32	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.39130072
33	STAT3_23295773_ChIP-Seq_U87_Human	1.37909884
34	P300_19829295_ChIP-Seq_ESCs_Human	1.35545588
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.29390080
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28299817
37	GATA3_26560356_Chip-Seq_TH1_Human	1.28194494
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27670679
39	TCF4_23295773_ChIP-Seq_U87_Human	1.27615643
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.27328543
41	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.26525205
42	SMRT_27268052_Chip-Seq_Bcells_Human	1.26377871
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25094422
44	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.23491090
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.22441125
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21762719
47	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.20518181
48	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19512386
49	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19429031
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17894707
51	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.17784877
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17534881
53	GATA3_27048872_Chip-Seq_THYMUS_Human	1.16716802
54	MYB_26560356_Chip-Seq_TH2_Human	1.15492970
55	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.13991988
56	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13740585
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12865510
58	ERG_20517297_ChIP-Seq_VCAP_Human	1.12765924
59	GATA3_26560356_Chip-Seq_TH2_Human	1.12245378
60	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.12031668
61	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11618003
62	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.11526301
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.11450228
64	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10984357
65	NCOR_22424771_ChIP-Seq_293T_Human	1.10138826
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.08008134
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06603437
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06418393
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.06205428
70	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.05842879
71	VDR_24787735_ChIP-Seq_THP-1_Human	1.05455404
72	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05281252
73	AR_25329375_ChIP-Seq_VCAP_Human	1.03522410
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02640691
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01458070
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.01191727
77	ERA_21632823_ChIP-Seq_H3396_Human	1.00526780
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00519791
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00519791
80	GBX2_23144817_ChIP-Seq_PC3_Human	0.98705547
81	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98482088
82	MYC_18940864_ChIP-ChIP_HL60_Human	0.97826016
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97365959
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.97221705
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.95803802
86	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.95351095
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94462931
88	RUNX_20019798_ChIP-Seq_JUKART_Human	0.94308806
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94138720
90	MYB_26560356_Chip-Seq_TH1_Human	0.93355924
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93218846
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93218846
93	STAT1_20625510_ChIP-Seq_HELA_Human	0.92949879
94	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.92582585
95	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.91857530
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.90347731
97	FOXP3_21729870_ChIP-Seq_TREG_Human	0.90332774
98	BCL6_27268052_Chip-Seq_Bcells_Human	0.90028585
99	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89870876
100	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89034297

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.89521389
2	MP0005410_abnormal_fertilization	3.44627654
3	MP0003172_abnormal_lysosome_physiology	3.21524363
4	MP0002736_abnormal_nociception_after	3.00235215
5	MP0002653_abnormal_ependyma_morphology	2.93448213
6	MP0001968_abnormal_touch/_nociception	2.77286371
7	MP0008057_abnormal_DNA_replication	2.49896196
8	MP0008058_abnormal_DNA_repair	2.47944505
9	MP0001929_abnormal_gametogenesis	2.38493027
10	MP0005671_abnormal_response_to	2.37884704
11	MP0000685_abnormal_immune_system	2.35646181
12	MP0002837_dystrophic_cardiac_calcinosis	2.32947885
13	MP0002210_abnormal_sex_determination	2.15807403
14	MP0000015_abnormal_ear_pigmentation	2.11446873
15	MP0003698_abnormal_male_reproductive	2.09437389
16	MP0000569_abnormal_digit_pigmentation	2.09417753
17	MP0001800_abnormal_humoral_immune	2.06259884
18	MP0010094_abnormal_chromosome_stability	2.05513402
19	MP0001835_abnormal_antigen_presentation	2.01727534
20	MP0005075_abnormal_melanosome_morpholog	1.99882785
21	MP0005645_abnormal_hypothalamus_physiol	1.90403942
22	MP0005360_urolithiasis	1.88130095
23	MP0000372_irregular_coat_pigmentation	1.85352519
24	MP0002095_abnormal_skin_pigmentation	1.74964916
25	MP0002396_abnormal_hematopoietic_system	1.74751376
26	MP0005423_abnormal_somatic_nervous	1.69172166
27	MP0003646_muscle_fatigue	1.66134168
28	MP0001145_abnormal_male_reproductive	1.58452577
29	MP0001790_abnormal_immune_system	1.56225323
30	MP0005387_immune_system_phenotype	1.56225323
31	MP0003718_maternal_effect	1.54264652
32	MP0001348_abnormal_lacrimal_gland	1.53106178
33	MP0009379_abnormal_foot_pigmentation	1.52707004
34	MP0002160_abnormal_reproductive_system	1.51635291
35	MP0005409_darkened_coat_color	1.49110576
36	MP0008872_abnormal_physiological_respon	1.48257985
37	MP0002452_abnormal_antigen_presenting	1.47276753
38	MP0005000_abnormal_immune_tolerance	1.46694156
39	MP0000653_abnormal_sex_gland	1.38897980
40	MP0005310_abnormal_salivary_gland	1.38662517
41	MP0002735_abnormal_chemical_nociception	1.38294071
42	MP0002723_abnormal_immune_serum	1.37831147
43	MP0009840_abnormal_foam_cell	1.37125243
44	MP0003183_abnormal_peptide_metabolism	1.29764346
45	MP0005379_endocrine/exocrine_gland_phen	1.28719036
46	MP0001485_abnormal_pinna_reflex	1.27208540
47	MP0002138_abnormal_hepatobiliary_system	1.26531737
48	MP0005174_abnormal_tail_pigmentation	1.25852003
49	MP0003763_abnormal_thymus_physiology	1.24612585
50	MP0002734_abnormal_mechanical_nocicepti	1.22327047
51	MP0003303_peritoneal_inflammation	1.22048778
52	MP0002420_abnormal_adaptive_immunity	1.19073352
53	MP0003868_abnormal_feces_composition	1.18993851
54	MP0001819_abnormal_immune_cell	1.17531031
55	MP0005464_abnormal_platelet_physiology	1.17296747
56	MP0004134_abnormal_chest_morphology	1.15312213
57	MP0002163_abnormal_gland_morphology	1.14442321
58	MP0009046_muscle_twitch	1.10378251
59	MP0009745_abnormal_behavioral_response	1.09647271
60	MP0002148_abnormal_hypersensitivity_rea	1.08506791
61	MP0002272_abnormal_nervous_system	1.07540115
62	MP0004742_abnormal_vestibular_system	1.06603903
63	MP0005389_reproductive_system_phenotype	1.05560627
64	MP0002909_abnormal_adrenal_gland	1.05480650
65	MP0002398_abnormal_bone_marrow	1.05440085
66	MP0000371_diluted_coat_color	1.04133691
67	MP0003693_abnormal_embryo_hatching	1.02161110
68	MP0000678_abnormal_parathyroid_gland	1.01106194
69	MP0000716_abnormal_immune_system	1.00072037
70	MP0002161_abnormal_fertility/fecundity	0.99646281
71	MP0001873_stomach_inflammation	0.99091664
72	MP0001984_abnormal_olfaction	0.98305376
73	MP0002693_abnormal_pancreas_physiology	0.97386137
74	MP0006276_abnormal_autonomic_nervous	0.94785663
75	MP0005535_abnormal_body_temperature	0.93731926
76	MP0002733_abnormal_thermal_nociception	0.91784181
77	MP0002139_abnormal_hepatobiliary_system	0.91108778
78	MP0005670_abnormal_white_adipose	0.91057148
79	MP0006036_abnormal_mitochondrial_physio	0.91014661
80	MP0001970_abnormal_pain_threshold	0.89620687
81	MP0001853_heart_inflammation	0.88696296
82	MP0003111_abnormal_nucleus_morphology	0.88405904
83	MP0003077_abnormal_cell_cycle	0.86391137
84	MP0001486_abnormal_startle_reflex	0.85678818
85	MP0003635_abnormal_synaptic_transmissio	0.82752690
86	MP0005220_abnormal_exocrine_pancreas	0.82446525
87	MP0002419_abnormal_innate_immunity	0.82381020
88	MP0002067_abnormal_sensory_capabilities	0.81949884
89	MP0003136_yellow_coat_color	0.80396456
90	MP0002277_abnormal_respiratory_mucosa	0.79465157
91	MP0000470_abnormal_stomach_morphology	0.79357645
92	MP0002429_abnormal_blood_cell	0.77845257
93	MP0000689_abnormal_spleen_morphology	0.74982011
94	MP0002933_joint_inflammation	0.74764391
95	MP0001501_abnormal_sleep_pattern	0.71502665
96	MP0002572_abnormal_emotion/affect_behav	0.69654679
97	MP0001119_abnormal_female_reproductive	0.69424012
98	MP0002064_seizures	0.68196565
99	MP0001963_abnormal_hearing_physiology	0.66433604
100	MP0001845_abnormal_inflammatory_respons	0.66005278

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	5.85629349
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.85629349
3	Recurrent sinusitis (HP:0011108)	5.15161687
4	Annular pancreas (HP:0001734)	4.75213856
5	Intestinal atresia (HP:0011100)	4.60499800
6	Gastrointestinal stroma tumor (HP:0100723)	4.35819986
7	Panhypogammaglobulinemia (HP:0003139)	3.71733255
8	Abnormal ciliary motility (HP:0012262)	3.51821533
9	Abnormal respiratory motile cilium morphology (HP:0005938)	3.51644236
10	Abnormal respiratory epithelium morphology (HP:0012253)	3.51644236
11	IgA deficiency (HP:0002720)	3.49335122
12	Agammaglobulinemia (HP:0004432)	3.24757109
13	Abnormality of T cell physiology (HP:0011840)	3.19563172
14	Abnormality of the pulmonary veins (HP:0011718)	3.11146370
15	Abnormality of cochlea (HP:0000375)	3.05264761
16	Azoospermia (HP:0000027)	3.04252566
17	Abnormal lung lobation (HP:0002101)	2.97173449
18	Duodenal stenosis (HP:0100867)	2.92014535
19	Small intestinal stenosis (HP:0012848)	2.92014535
20	Congenital, generalized hypertrichosis (HP:0004540)	2.91681461
21	IgM deficiency (HP:0002850)	2.86487625
22	Abnormality of lateral ventricle (HP:0030047)	2.81681613
23	Abnormal respiratory motile cilium physiology (HP:0012261)	2.73184582
24	Bony spicule pigmentary retinopathy (HP:0007737)	2.72870621
25	Spontaneous abortion (HP:0005268)	2.70027624
26	Attenuation of retinal blood vessels (HP:0007843)	2.69894794
27	Abnormality of the prostate (HP:0008775)	2.66956954
28	Meckel diverticulum (HP:0002245)	2.66438597
29	Recurrent bronchitis (HP:0002837)	2.65485895
30	Tubulointerstitial nephritis (HP:0001970)	2.65331386
31	Abnormality of the ileum (HP:0001549)	2.55375850
32	Albinism (HP:0001022)	2.43233750
33	Prostate neoplasm (HP:0100787)	2.41748410
34	Decreased central vision (HP:0007663)	2.40401595
35	Gastrointestinal atresia (HP:0002589)	2.36999582
36	IgG deficiency (HP:0004315)	2.32495169
37	Morphological abnormality of the inner ear (HP:0011390)	2.30044386
38	Abnormal spermatogenesis (HP:0008669)	2.29711858
39	Ectopic kidney (HP:0000086)	2.18671058
40	Abnormality of the duodenum (HP:0002246)	2.18434667
41	Hypoplasia of the uterus (HP:0000013)	2.17594713
42	Recurrent pneumonia (HP:0006532)	2.16690129
43	Hydroureter (HP:0000072)	2.16648286
44	Single umbilical artery (HP:0001195)	2.15039169
45	Abnormality of the fetal cardiovascular system (HP:0010948)	2.15039169
46	Abnormal umbilical cord blood vessels (HP:0011403)	2.15039169
47	Colon cancer (HP:0003003)	2.14984503
48	Genetic anticipation (HP:0003743)	2.14264776
49	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.12295867
50	Recurrent lower respiratory tract infections (HP:0002783)	2.12211977
51	Abnormality of DNA repair (HP:0003254)	2.07296087
52	Vasculitis (HP:0002633)	2.03105603
53	Chromsome breakage (HP:0040012)	2.02214255
54	Lymphopenia (HP:0001888)	2.01850335
55	Hyperventilation (HP:0002883)	1.99479421
56	Colitis (HP:0002583)	1.97815138
57	Febrile seizures (HP:0002373)	1.97383396
58	Hypoplastic ischia (HP:0003175)	1.96818728
59	Meningitis (HP:0001287)	1.96576922
60	Hypoplastic left heart (HP:0004383)	1.95077473
61	Recurrent viral infections (HP:0004429)	1.95010355
62	Tinnitus (HP:0000360)	1.94640303
63	Constricted visual fields (HP:0001133)	1.93652476
64	Abnormality of male internal genitalia (HP:0000022)	1.92509622
65	Recurrent fungal infections (HP:0002841)	1.90422495
66	Nephronophthisis (HP:0000090)	1.88793758
67	Intellectual disability, profound (HP:0002187)	1.87648619
68	Abnormal finger flexion creases (HP:0006143)	1.87169401
69	Hypoplasia of the radius (HP:0002984)	1.85383826
70	Abolished electroretinogram (ERG) (HP:0000550)	1.83750973
71	Molar tooth sign on MRI (HP:0002419)	1.83614473
72	Abnormality of midbrain morphology (HP:0002418)	1.83614473
73	Impaired vibration sensation in the lower limbs (HP:0002166)	1.82264405
74	Neoplasm of the adrenal cortex (HP:0100641)	1.82000920
75	Scotoma (HP:0000575)	1.81712101
76	Progressive cerebellar ataxia (HP:0002073)	1.80790850
77	Abnormality of T cells (HP:0002843)	1.78806210
78	Reticulocytopenia (HP:0001896)	1.78428093
79	Autoimmune thrombocytopenia (HP:0001973)	1.78035556
80	Chronic mucocutaneous candidiasis (HP:0002728)	1.77787097
81	Recurrent cutaneous fungal infections (HP:0011370)	1.77787097
82	Abnormality of the renal medulla (HP:0100957)	1.76429942
83	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.76291805
84	Hypoplasia of the fovea (HP:0007750)	1.76194566
85	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.76194566
86	Methylmalonic aciduria (HP:0012120)	1.76078766
87	Renal Fanconi syndrome (HP:0001994)	1.73687406
88	Acute myeloid leukemia (HP:0004808)	1.72202474
89	Dysautonomia (HP:0002459)	1.71943803
90	Volvulus (HP:0002580)	1.71177323
91	Atonic seizures (HP:0010819)	1.70694570
92	Clumsiness (HP:0002312)	1.69562295
93	Pustule (HP:0200039)	1.68542045
94	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.67959541
95	Cone-rod dystrophy (HP:0000548)	1.65633320
96	Myelodysplasia (HP:0002863)	1.61691711
97	Pulmonary fibrosis (HP:0002206)	1.61664218
98	Abnormality of renal resorption (HP:0011038)	1.61482172
99	Increased hepatocellular lipid droplets (HP:0006565)	1.59727426
100	Viral hepatitis (HP:0006562)	1.58701405

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	3.44827691
2	RIPK4	3.21774260
3	PNCK	3.16436119
4	KIT	2.81512097
5	CDK19	2.74946129
6	FRK	2.62370058
7	PLK4	2.39715268
8	CCNB1	2.33280172
9	TAF1	2.27855321
10	PLK2	2.26558562
11	BMPR2	2.22761652
12	TEC	2.22497378
13	TAOK3	2.19275042
14	STK16	2.07798643
15	VRK1	2.01320158
16	ZAK	2.00918185
17	SYK	1.94861401
18	MAP2K2	1.77755225
19	CSF1R	1.74692489
20	BMPR1B	1.67078649
21	EIF2AK3	1.54056758
22	VRK2	1.49323128
23	PTK2B	1.45103073
24	IKBKE	1.44694194
25	NTRK3	1.44266666
26	CDC7	1.44154883
27	OXSR1	1.36673212
28	CDK12	1.34051959
29	CDK4	1.25944110
30	BTK	1.23783881
31	INSRR	1.19394947
32	CAMK1G	1.16760514
33	TLK1	1.14697780
34	BLK	1.14473045
35	MAP4K1	1.13771189
36	IKBKB	1.11480665
37	STK38L	1.03067670
38	GRK1	1.02717195
39	LYN	1.01066762
40	BUB1	0.96196443
41	PDK2	0.95208603
42	WEE1	0.94343716
43	PRKCQ	0.90338967
44	NME1	0.83459325
45	PASK	0.83409311
46	GRK5	0.83286489
47	TBK1	0.82424283
48	DAPK1	0.81654668
49	STK38	0.79203225
50	CHEK1	0.78337272
51	ATR	0.78334746
52	NLK	0.75630005
53	CHUK	0.73820979
54	PIK3CG	0.69297316
55	IRAK4	0.66827084
56	CDK3	0.66720533
57	AURKA	0.66552284
58	NEK9	0.65930723
59	PLK1	0.62371353
60	DAPK2	0.61413606
61	MAPK15	0.61100827
62	MELK	0.60772314
63	JAK3	0.60704282
64	CHEK2	0.59598328
65	BRD4	0.59514724
66	SGK1	0.59031177
67	TNIK	0.56641954
68	DAPK3	0.54600671
69	PDK1	0.54538502
70	CDK2	0.54095777
71	NME2	0.53100007
72	MAP3K14	0.51380352
73	MATK	0.50683176
74	FGR	0.50600188
75	RPS6KA5	0.50175933
76	ITK	0.49384619
77	CSNK1E	0.48235505
78	MST4	0.47819990
79	TTK	0.47758379
80	LCK	0.46755777
81	ATM	0.45966037
82	FGFR3	0.45928581
83	MAPK7	0.44859736
84	MAPKAPK5	0.44303452
85	PRKCZ	0.41684652
86	MAPK4	0.40849900
87	MAP3K10	0.40157067
88	JAK1	0.39601095
89	PRKG1	0.38537747
90	PRKCH	0.38479908
91	PRKCI	0.38332950
92	CSNK2A2	0.37784879
93	GSK3B	0.37579999
94	PDPK1	0.36782753
95	IRAK1	0.36520120
96	PRKACB	0.35339337
97	MARK3	0.34509967
98	PRKCB	0.34090662
99	PLK3	0.34085001
100	PKN1	0.33565231

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.77403243
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.04517904
3	Allograft rejection_Homo sapiens_hsa05330	3.65089302
4	Asthma_Homo sapiens_hsa05310	3.51441649
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.38643436
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.11316207
7	Primary immunodeficiency_Homo sapiens_hsa05340	3.07625631
8	Graft-versus-host disease_Homo sapiens_hsa05332	3.01666994
9	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.46082167
10	Ribosome_Homo sapiens_hsa03010	2.39385663
11	Homologous recombination_Homo sapiens_hsa03440	2.30675222
12	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.08031003
13	Olfactory transduction_Homo sapiens_hsa04740	1.73269321
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.71918742
15	Viral myocarditis_Homo sapiens_hsa05416	1.64007786
16	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.58377423
17	beta-Alanine metabolism_Homo sapiens_hsa00410	1.58144863
18	Mismatch repair_Homo sapiens_hsa03430	1.54535485
19	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.51101742
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.49964392
21	Leishmaniasis_Homo sapiens_hsa05140	1.36481871
22	DNA replication_Homo sapiens_hsa03030	1.24570965
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16459876
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14756341
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.13482634
26	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.11407904
27	Influenza A_Homo sapiens_hsa05164	1.10285996
28	Base excision repair_Homo sapiens_hsa03410	1.06269915
29	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.00264151
30	Parkinsons disease_Homo sapiens_hsa05012	0.97442533
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.95459406
32	Calcium signaling pathway_Homo sapiens_hsa04020	0.91341985
33	Non-homologous end-joining_Homo sapiens_hsa03450	0.91008666
34	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.90176836
35	Herpes simplex infection_Homo sapiens_hsa05168	0.85138648
36	Oocyte meiosis_Homo sapiens_hsa04114	0.84471300
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83892926
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83284798
39	Alcoholism_Homo sapiens_hsa05034	0.81601325
40	Oxidative phosphorylation_Homo sapiens_hsa00190	0.81475043
41	Nicotine addiction_Homo sapiens_hsa05033	0.79565091
42	Toxoplasmosis_Homo sapiens_hsa05145	0.79281123
43	Taste transduction_Homo sapiens_hsa04742	0.77647984
44	RNA polymerase_Homo sapiens_hsa03020	0.73733158
45	Phototransduction_Homo sapiens_hsa04744	0.72810643
46	RNA transport_Homo sapiens_hsa03013	0.71688598
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70777615
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69881980
49	RNA degradation_Homo sapiens_hsa03018	0.69060969
50	Renin-angiotensin system_Homo sapiens_hsa04614	0.66893123
51	Serotonergic synapse_Homo sapiens_hsa04726	0.65274930
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.59794983
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.59673407
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58663860
55	Viral carcinogenesis_Homo sapiens_hsa05203	0.58482402
56	Retinol metabolism_Homo sapiens_hsa00830	0.56536776
57	Renin secretion_Homo sapiens_hsa04924	0.55123231
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54424438
59	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.54001928
60	Morphine addiction_Homo sapiens_hsa05032	0.53461438
61	Huntingtons disease_Homo sapiens_hsa05016	0.52385970
62	Circadian entrainment_Homo sapiens_hsa04713	0.50947990
63	p53 signaling pathway_Homo sapiens_hsa04115	0.50879151
64	Salivary secretion_Homo sapiens_hsa04970	0.50496334
65	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49526592
66	Insulin secretion_Homo sapiens_hsa04911	0.48758075
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47734840
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47532506
69	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.45947271
70	Measles_Homo sapiens_hsa05162	0.45853096
71	Basal transcription factors_Homo sapiens_hsa03022	0.45540057
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.44854099
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44723258
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44669158
75	Tuberculosis_Homo sapiens_hsa05152	0.43345106
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41039828
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.41020433
78	Purine metabolism_Homo sapiens_hsa00230	0.40042008
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.38236404
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38164630
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37449498
82	Proteasome_Homo sapiens_hsa03050	0.35736569
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.35107372
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34911353
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34091576
86	Long-term potentiation_Homo sapiens_hsa04720	0.33930577
87	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.33779481
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.33179117
89	Gastric acid secretion_Homo sapiens_hsa04971	0.33135016
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32652024
91	Platelet activation_Homo sapiens_hsa04611	0.31699561
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30707329
93	Linoleic acid metabolism_Homo sapiens_hsa00591	0.29533547
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.29476551
95	Cell cycle_Homo sapiens_hsa04110	0.28639298
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.28356045
97	Alzheimers disease_Homo sapiens_hsa05010	0.28234091
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.27975832
99	Chemokine signaling pathway_Homo sapiens_hsa04062	0.27886355
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.27431404

ANKRD26P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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