ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of relaxation of muscle (GO:1901077)	6.11921588
2	righting reflex (GO:0060013)	5.94325164
3	protein localization to Golgi apparatus (GO:0034067)	5.86815823
4	multicellular organismal movement (GO:0050879)	5.57297530
5	musculoskeletal movement (GO:0050881)	5.57297530
6	protein targeting to Golgi (GO:0000042)	5.16415146
7	establishment of protein localization to Golgi (GO:0072600)	5.09232957
8	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.94317874
9	neuromuscular process controlling posture (GO:0050884)	4.91966037
10	carnitine transport (GO:0015879)	4.86886381
11	amino-acid betaine transport (GO:0015838)	4.86886381
12	neurofilament cytoskeleton organization (GO:0060052)	4.84275173
13	dendritic spine morphogenesis (GO:0060997)	4.59550227
14	positive regulation of p38MAPK cascade (GO:1900745)	4.39188694
15	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.29542538
16	nephron tubule morphogenesis (GO:0072078)	4.27367991
17	nephron epithelium morphogenesis (GO:0072088)	4.27367991
18	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	4.20567671
19	peroxisome fission (GO:0016559)	4.06826053
20	heparin metabolic process (GO:0030202)	4.03075928
21	heparin biosynthetic process (GO:0030210)	4.03075928
22	receptor catabolic process (GO:0032801)	3.94495497
23	endocrine hormone secretion (GO:0060986)	3.85675126
24	import into cell (GO:0098657)	3.81664228
25	xenobiotic catabolic process (GO:0042178)	3.75919459
26	regulation of extracellular matrix disassembly (GO:0010715)	3.74757238
27	nerve growth factor signaling pathway (GO:0038180)	3.72361365
28	intra-Golgi vesicle-mediated transport (GO:0006891)	3.70601939
29	replacement ossification (GO:0036075)	3.63940004
30	endochondral ossification (GO:0001958)	3.63940004
31	establishment of endothelial barrier (GO:0061028)	3.63154819
32	insulin secretion (GO:0030073)	3.61180498
33	heart valve formation (GO:0003188)	3.58598617
34	quaternary ammonium group transport (GO:0015697)	3.57978026
35	cobalamin metabolic process (GO:0009235)	3.57118158
36	spinal cord motor neuron differentiation (GO:0021522)	3.56932887
37	regulation of p38MAPK cascade (GO:1900744)	3.52236554
38	cellular response to gonadotropin stimulus (GO:0071371)	3.49960441
39	regulation of skeletal muscle contraction (GO:0014819)	3.49532837
40	photoreceptor cell maintenance (GO:0045494)	3.49481910
41	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.45017539
42	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.43910375
43	relaxation of cardiac muscle (GO:0055119)	3.42068686
44	regulation of glomerulus development (GO:0090192)	3.41813342
45	neurotransmitter uptake (GO:0001504)	3.41404326
46	carnitine shuttle (GO:0006853)	3.36329020
47	endothelial cell development (GO:0001885)	3.35203699
48	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.34994589
49	cornea development in camera-type eye (GO:0061303)	3.30817592
50	retina vasculature morphogenesis in camera-type eye (GO:0061299)	3.25559093
51	ovulation from ovarian follicle (GO:0001542)	3.19235198
52	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	3.19133984
53	renal tubule morphogenesis (GO:0061333)	3.18869288
54	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.16328334
55	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.09563326
56	chemosensory behavior (GO:0007635)	3.09087309
57	reflex (GO:0060004)	3.08665688
58	negative regulation of execution phase of apoptosis (GO:1900118)	3.07556609
59	L-alpha-amino acid transmembrane transport (GO:1902475)	3.06441112
60	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.01875807
61	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.00702682
62	regulation of metalloenzyme activity (GO:0048552)	2.99860026
63	hair follicle development (GO:0001942)	2.99515695
64	carnitine transmembrane transport (GO:1902603)	2.97768424
65	keratan sulfate catabolic process (GO:0042340)	2.95867694
66	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.95356440
67	negative regulation of actin filament bundle assembly (GO:0032232)	2.94839857
68	nephron tubule formation (GO:0072079)	2.94327639
69	carnitine metabolic process (GO:0009437)	2.90317604
70	protein-chromophore linkage (GO:0018298)	2.89644593
71	response to nerve growth factor (GO:1990089)	2.88137856
72	cellular response to nerve growth factor stimulus (GO:1990090)	2.88137856
73	regulation of glutamate receptor signaling pathway (GO:1900449)	2.87610387
74	regulation of DNA damage checkpoint (GO:2000001)	2.86406490
75	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.83102564
76	negative regulation of axon guidance (GO:1902668)	2.79040071
77	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.78404531
78	toxin metabolic process (GO:0009404)	2.75376951
79	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.74492770
80	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.74492770
81	dendritic spine organization (GO:0097061)	2.72601249
82	ventricular cardiac muscle cell action potential (GO:0086005)	2.70818188
83	cardiac muscle cell action potential (GO:0086001)	2.70532406
84	response to pheromone (GO:0019236)	2.68941405
85	embryonic heart tube development (GO:0035050)	2.68271376
86	L-amino acid import (GO:0043092)	2.67982775
87	potassium ion import (GO:0010107)	2.67096457
88	positive regulation of histone H3-K4 methylation (GO:0051571)	2.66618575
89	oxidative demethylation (GO:0070989)	2.66376575
90	fatty acid transmembrane transport (GO:1902001)	2.64722858
91	muscle cell cellular homeostasis (GO:0046716)	2.64703462
92	hypotonic response (GO:0006971)	2.63036271
93	cellular response to nicotine (GO:0071316)	2.62873407
94	cellular protein catabolic process (GO:0044257)	2.61368402
95	regulation of gonadotropin secretion (GO:0032276)	2.59137176
96	regulation of phospholipid biosynthetic process (GO:0071071)	2.57504648
97	regulation of phospholipase A2 activity (GO:0032429)	2.57295913
98	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.56383756
99	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.54349319
100	dicarboxylic acid catabolic process (GO:0043649)	2.54138750

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.52502515
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.86698371
3	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.12224106
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.02699922
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.87720981
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75994006
7	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.57993063
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.50343987
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.39241477
10	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.30753508
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.29983951
12	TP53_16413492_ChIP-PET_HCT116_Human	2.15729325
13	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.04706210
14	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.99849179
15	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.96914427
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.94822766
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80455147
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71731885
19	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.69261504
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.68224009
21	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.62261595
22	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.59746434
23	FUS_26573619_Chip-Seq_HEK293_Human	1.58299695
24	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.55632670
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55155667
26	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.55111848
27	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.55111848
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.54982478
29	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.54645038
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.51834154
31	CJUN_26792858_Chip-Seq_BT549_Human	1.48403809
32	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.43437766
33	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.40291423
34	TP53_18474530_ChIP-ChIP_U2OS_Human	1.38945160
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37377642
36	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.36614880
37	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.36358651
38	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34038959
39	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.33938836
40	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.33736236
41	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.33060561
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.31201322
43	AHR_22903824_ChIP-Seq_MCF-7_Human	1.31035162
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.30375520
45	VDR_22108803_ChIP-Seq_LS180_Human	1.29684673
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29220946
47	P300_19829295_ChIP-Seq_ESCs_Human	1.28006978
48	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27426498
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26960309
50	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.26069993
51	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.23510737
52	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.23498910
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22761630
54	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.21630804
55	RXR_22108803_ChIP-Seq_LS180_Human	1.21576152
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21009327
57	STAT3_23295773_ChIP-Seq_U87_Human	1.20970019
58	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.20484234
59	TBL1_22424771_ChIP-Seq_293T_Human	1.20222053
60	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.19738520
61	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.19107089
62	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17320685
63	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.16534197
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15746346
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.15746346
66	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.14394244
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13436091
68	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.11693656
69	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.11522474
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10414673
71	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.09170716
72	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.08435741
73	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.08202826
74	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08168812
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07655044
76	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.07641560
77	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.06785654
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06398323
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06200114
80	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.05845658
81	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05462662
82	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.04933196
83	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04741600
84	NFYB_21822215_ChIP-Seq_K562_Human	1.03616931
85	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.02787569
86	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02648075
87	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.01478005
88	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98329724
89	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.98197725
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97823153
91	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97795567
92	AR_25329375_ChIP-Seq_VCAP_Human	0.97373084
93	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.96905370
94	TP63_23658742_ChIP-Seq_EP156T_Human	0.95932428
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95836281
96	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95492410
97	TCF4_23295773_ChIP-Seq_U87_Human	0.94690128
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.93260951
99	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.91710481
100	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.91710481

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	4.58039222
2	MP0002837_dystrophic_cardiac_calcinosis	3.77941024
3	MP0000751_myopathy	3.35351987
4	MP0008057_abnormal_DNA_replication	2.93622724
5	MP0005503_abnormal_tendon_morphology	2.78983868
6	MP0002090_abnormal_vision	2.64577717
7	MP0003195_calcinosis	2.59508936
8	MP0001879_abnormal_lymphatic_vessel	2.57523405
9	MP0004215_abnormal_myocardial_fiber	2.36100435
10	MP0001986_abnormal_taste_sensitivity	2.32164905
11	MP0005248_abnormal_Harderian_gland	2.09169257
12	MP0004134_abnormal_chest_morphology	2.02240706
13	MP0002108_abnormal_muscle_morphology	1.90844625
14	MP0006276_abnormal_autonomic_nervous	1.90828799
15	MP0002295_abnormal_pulmonary_circulatio	1.87893948
16	MP0000372_irregular_coat_pigmentation	1.87670796
17	MP0003137_abnormal_impulse_conducting	1.87329326
18	MP0002971_abnormal_brown_adipose	1.81188922
19	MP0002163_abnormal_gland_morphology	1.78626277
20	MP0005275_abnormal_skin_tensile	1.76904822
21	MP0003656_abnormal_erythrocyte_physiolo	1.70011613
22	MP0003878_abnormal_ear_physiology	1.65715157
23	MP0005377_hearing/vestibular/ear_phenot	1.65715157
24	MP0008438_abnormal_cutaneous_collagen	1.64401186
25	MP0005448_abnormal_energy_balance	1.63090647
26	MP0006072_abnormal_retinal_apoptosis	1.61930210
27	MP0003646_muscle_fatigue	1.60225173
28	MP0004142_abnormal_muscle_tone	1.58297129
29	MP0001661_extended_life_span	1.53661953
30	MP0002396_abnormal_hematopoietic_system	1.52750908
31	MP0002269_muscular_atrophy	1.46858507
32	MP0004510_myositis	1.46384035
33	MP0005379_endocrine/exocrine_gland_phen	1.46076723
34	MP0004272_abnormal_basement_membrane	1.45088482
35	MP0005083_abnormal_biliary_tract	1.43088160
36	MP0009046_muscle_twitch	1.40406256
37	MP0002067_abnormal_sensory_capabilities	1.39934380
38	MP0004085_abnormal_heartbeat	1.39464086
39	MP0010386_abnormal_urinary_bladder	1.33529886
40	MP0005408_hypopigmentation	1.32783792
41	MP0005409_darkened_coat_color	1.32772389
42	MP0005257_abnormal_intraocular_pressure	1.28177715
43	MP0001756_abnormal_urination	1.25986145
44	MP0010329_abnormal_lipoprotein_level	1.25878800
45	MP0000749_muscle_degeneration	1.24095912
46	MP0003828_pulmonary_edema	1.23442440
47	MP0001324_abnormal_eye_pigmentation	1.21303637
48	MP0005084_abnormal_gallbladder_morpholo	1.21028370
49	MP0001502_abnormal_circadian_rhythm	1.19027977
50	MP0009780_abnormal_chondrocyte_physiolo	1.18358633
51	MP0000569_abnormal_digit_pigmentation	1.17533129
52	MP0003183_abnormal_peptide_metabolism	1.17322973
53	MP0005187_abnormal_penis_morphology	1.16608024
54	MP0006082_CNS_inflammation	1.15876409
55	MP0003122_maternal_imprinting	1.15203882
56	MP0005171_absent_coat_pigmentation	1.14903796
57	MP0005058_abnormal_lysosome_morphology	1.13695201
58	MP0002229_neurodegeneration	1.11985717
59	MP0005369_muscle_phenotype	1.11601074
60	MP0000631_abnormal_neuroendocrine_gland	1.10511600
61	MP0003787_abnormal_imprinting	1.10447298
62	MP0005330_cardiomyopathy	1.07865783
63	MP0004084_abnormal_cardiac_muscle	1.07358111
64	MP0005646_abnormal_pituitary_gland	1.04715234
65	MP0004087_abnormal_muscle_fiber	1.03382113
66	MP0003279_aneurysm	1.02614227
67	MP0005253_abnormal_eye_physiology	1.02387944
68	MP0005085_abnormal_gallbladder_physiolo	1.00724157
69	MP0000013_abnormal_adipose_tissue	0.99377705
70	MP0002106_abnormal_muscle_physiology	0.99129875
71	MP0003806_abnormal_nucleotide_metabolis	0.98457070
72	MP0003566_abnormal_cell_adhesion	0.96618723
73	MP0005551_abnormal_eye_electrophysiolog	0.95259966
74	MP0000371_diluted_coat_color	0.93980576
75	MP0002909_abnormal_adrenal_gland	0.92216736
76	MP0002078_abnormal_glucose_homeostasis	0.90482641
77	MP0000920_abnormal_myelination	0.89666761
78	MP0001542_abnormal_bone_strength	0.88529326
79	MP0000747_muscle_weakness	0.86550814
80	MP0005595_abnormal_vascular_smooth	0.86184602
81	MP0005174_abnormal_tail_pigmentation	0.85602995
82	MP0001486_abnormal_startle_reflex	0.85405258
83	MP0006138_congestive_heart_failure	0.85391623
84	MP0003252_abnormal_bile_duct	0.84671710
85	MP0001963_abnormal_hearing_physiology	0.84446174
86	MP0003045_fibrosis	0.83583713
87	MP0000767_abnormal_smooth_muscle	0.83496724
88	MP0003634_abnormal_glial_cell	0.82903422
89	MP0002254_reproductive_system_inflammat	0.82715667
90	MP0003755_abnormal_palate_morphology	0.80652978
91	MP0005195_abnormal_posterior_eye	0.80461371
92	MP0008775_abnormal_heart_ventricle	0.80390416
93	MP0002876_abnormal_thyroid_physiology	0.80117386
94	MP0003879_abnormal_hair_cell	0.78565823
95	MP0001485_abnormal_pinna_reflex	0.77808410
96	MP0002069_abnormal_eating/drinking_beha	0.76480032
97	MP0002557_abnormal_social/conspecific_i	0.75548323
98	MP0005165_increased_susceptibility_to	0.75426792
99	MP0004133_heterotaxia	0.74715456
100	MP0004019_abnormal_vitamin_homeostasis	0.74050147

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tongue fasciculations (HP:0001308)	6.78294613
2	Muscle fibrillation (HP:0010546)	6.00381356
3	Large for gestational age (HP:0001520)	5.51604594
4	Vacuolated lymphocytes (HP:0001922)	5.16212503
5	Increased neuronal autofluorescent lipopigment (HP:0002074)	5.14862396
6	Slow saccadic eye movements (HP:0000514)	4.71436643
7	Increased cerebral lipofuscin (HP:0011813)	4.27093668
8	Syncope (HP:0001279)	3.73682774
9	Prolonged partial thromboplastin time (HP:0003645)	3.57837830
10	Hypothermia (HP:0002045)	3.53774464
11	Bundle branch block (HP:0011710)	3.52460212
12	Subacute progressive viral hepatitis (HP:0006572)	3.49717181
13	Abnormality of the renal medulla (HP:0100957)	3.43025797
14	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.39368684
15	Abnormality of the renal cortex (HP:0011035)	3.36739683
16	Joint hemorrhage (HP:0005261)	3.31473680
17	Tubular atrophy (HP:0000092)	3.26805296
18	Vascular calcification (HP:0004934)	3.13699649
19	Nephronophthisis (HP:0000090)	3.08658123
20	Pancreatic islet-cell hyperplasia (HP:0004510)	3.08181746
21	Cardiovascular calcification (HP:0011915)	3.06978899
22	Muscle fiber splitting (HP:0003555)	3.01024441
23	Micronodular cirrhosis (HP:0001413)	2.97502048
24	Tubulointerstitial fibrosis (HP:0005576)	2.95882740
25	Asymmetric septal hypertrophy (HP:0001670)	2.88133062
26	Abolished electroretinogram (ERG) (HP:0000550)	2.85351868
27	Pigmentary retinal degeneration (HP:0001146)	2.79534160
28	Postural tremor (HP:0002174)	2.77687755
29	Increased CSF protein (HP:0002922)	2.69539825
30	Diaphragmatic weakness (HP:0009113)	2.67759030
31	Abnormality of the intrinsic pathway (HP:0010989)	2.67694864
32	Ventricular arrhythmia (HP:0004308)	2.66072655
33	Bilateral sensorineural hearing impairment (HP:0008619)	2.63292557
34	Abnormality of the ischium (HP:0003174)	2.61903574
35	Atrial fibrillation (HP:0005110)	2.59690832
36	Septo-optic dysplasia (HP:0100842)	2.58416541
37	Asplenia (HP:0001746)	2.54696179
38	Hypokinesia (HP:0002375)	2.52490690
39	Clumsiness (HP:0002312)	2.40260162
40	Abnormality of saccadic eye movements (HP:0000570)	2.34824662
41	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.32621756
42	Chronic diarrhea (HP:0002028)	2.31028906
43	Abnormality of dental color (HP:0011073)	2.26490550
44	Nonimmune hydrops fetalis (HP:0001790)	2.24795179
45	Abnormality of the calf musculature (HP:0001430)	2.23859218
46	Primary atrial arrhythmia (HP:0001692)	2.21976547
47	Stridor (HP:0010307)	2.18682384
48	Barrel-shaped chest (HP:0001552)	2.13573359
49	Polyuria (HP:0000103)	2.12851848
50	Sudden death (HP:0001699)	2.12764686
51	Double outlet right ventricle (HP:0001719)	2.12590317
52	Congenital malformation of the right heart (HP:0011723)	2.12590317
53	Epidermoid cyst (HP:0200040)	2.10742161
54	Severe visual impairment (HP:0001141)	2.09893033
55	Supraventricular tachycardia (HP:0004755)	2.09223671
56	Abnormality of renal excretion (HP:0011036)	2.09168908
57	Limb ataxia (HP:0002070)	2.07802336
58	Abnormal drinking behavior (HP:0030082)	2.07210983
59	Polydipsia (HP:0001959)	2.07210983
60	Impaired smooth pursuit (HP:0007772)	2.06908551
61	Spinal muscular atrophy (HP:0007269)	2.06518953
62	Tubulointerstitial abnormality (HP:0001969)	2.05364868
63	Supraventricular arrhythmia (HP:0005115)	2.02423797
64	Hypoplastic ischia (HP:0003175)	2.01278489
65	Neonatal hypoglycemia (HP:0001998)	2.00609067
66	Absent eyebrow (HP:0002223)	2.00485538
67	Generalized aminoaciduria (HP:0002909)	2.00419037
68	Fair hair (HP:0002286)	1.99832337
69	Abnormal pancreas size (HP:0012094)	1.99633107
70	Molar tooth sign on MRI (HP:0002419)	1.99405963
71	Abnormality of midbrain morphology (HP:0002418)	1.99405963
72	Adactyly (HP:0009776)	1.96575060
73	Medial flaring of the eyebrow (HP:0010747)	1.95341172
74	Hypotrichosis (HP:0001006)	1.93377343
75	Cervical subluxation (HP:0003308)	1.90919358
76	Prolonged QT interval (HP:0001657)	1.90585806
77	Tachypnea (HP:0002789)	1.88190595
78	Ketoacidosis (HP:0001993)	1.87281190
79	Progressive neurologic deterioration (HP:0002344)	1.86299970
80	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.85643287
81	Persistence of primary teeth (HP:0006335)	1.85281930
82	Insulin-resistant diabetes mellitus (HP:0000831)	1.84258654
83	Hypoproteinemia (HP:0003075)	1.83353899
84	Beaking of vertebral bodies (HP:0004568)	1.80807486
85	Disproportionate short-trunk short stature (HP:0003521)	1.80436419
86	Increased number of teeth (HP:0011069)	1.79921550
87	Hepatocellular carcinoma (HP:0001402)	1.78842188
88	Right ventricular cardiomyopathy (HP:0011663)	1.78472749
89	Heart block (HP:0012722)	1.77005519
90	Progressive visual loss (HP:0000529)	1.76280745
91	Palpitations (HP:0001962)	1.75006236
92	Viral hepatitis (HP:0006562)	1.74797121
93	Exocrine pancreatic insufficiency (HP:0001738)	1.74571464
94	Exotropia (HP:0000577)	1.73476211
95	Lipoatrophy (HP:0100578)	1.73469962
96	Abnormality of the frontal sinuses (HP:0002687)	1.72628311
97	Stage 5 chronic kidney disease (HP:0003774)	1.68074537
98	Abnormal atrioventricular conduction (HP:0005150)	1.66678068
99	Abnormal urine output (HP:0012590)	1.66098501
100	Pancreatic cysts (HP:0001737)	1.65521947

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38	5.36777693
2	BLK	4.96419674
3	STK38L	3.86045966
4	STK39	3.53985571
5	PRPF4B	3.03742905
6	MAP3K6	2.88397938
7	PDK2	2.87000323
8	MAPK13	2.86332451
9	WNK3	2.53866770
10	MYLK	2.38148969
11	MAP3K4	2.30301599
12	WNK4	1.98666378
13	TNIK	1.84642763
14	FGFR4	1.74240058
15	PIK3CA	1.73812320
16	EPHA3	1.73163832
17	PRKD2	1.71187893
18	TIE1	1.70870766
19	GRK1	1.70070537
20	STK4	1.68045441
21	MAP2K7	1.60077988
22	DAPK2	1.59693201
23	WNK1	1.54005322
24	MST4	1.54000677
25	TAOK3	1.50622463
26	MKNK2	1.45510687
27	CAMK2D	1.45150146
28	STK24	1.29713649
29	FRK	1.25467728
30	NTRK2	1.23194853
31	TRPM7	1.22492764
32	AKT3	1.19406422
33	CAMK2G	1.19278085
34	MAP2K6	1.18602981
35	TGFBR2	1.14077565
36	PAK3	1.04459079
37	BRD4	0.92998181
38	BMPR1B	0.92456869
39	ABL2	0.88985819
40	ERBB3	0.87344541
41	LATS2	0.86900327
42	PRKD1	0.85159973
43	MATK	0.82295156
44	OBSCN	0.78907590
45	PRKCE	0.78793724
46	PTK2B	0.73646828
47	NLK	0.72569388
48	OXSR1	0.70177692
49	MAPK12	0.68210342
50	PHKG1	0.64979879
51	PHKG2	0.64979879
52	MAP2K4	0.58195206
53	STK3	0.57573828
54	FGFR1	0.56600907
55	SGK2	0.56246444
56	EIF2AK3	0.54613805
57	CAMK2A	0.53991723
58	CAMK2B	0.53674846
59	PRKAA1	0.51188289
60	EGFR	0.49835249
61	AKT2	0.49230032
62	MAP3K7	0.46951564
63	RPS6KB2	0.46749734
64	ZAP70	0.45519213
65	MKNK1	0.43923648
66	TAOK2	0.43755543
67	TNK2	0.42006036
68	PDGFRB	0.41530174
69	ABL1	0.41146984
70	STK16	0.40881162
71	PRKCG	0.40004989
72	NTRK1	0.39274563
73	PRKCQ	0.38158772
74	TTN	0.37626749
75	CDK19	0.37598861
76	PRKAA2	0.37020227
77	ADRBK1	0.34895619
78	GSK3A	0.34848235
79	LATS1	0.34316580
80	RPS6KA5	0.34046340
81	LMTK2	0.32860057
82	NEK9	0.32434690
83	INSRR	0.32096182
84	ILK	0.31938826
85	TGFBR1	0.31737514
86	PKN2	0.31605312
87	SYK	0.30804447
88	PRKACA	0.29995140
89	MAPK4	0.29386698
90	DAPK1	0.29180924
91	SGK223	0.28999297
92	SGK494	0.28999297
93	FLT3	0.28526730
94	DAPK3	0.28449261
95	AKT1	0.28386823
96	DYRK3	0.27805869
97	EPHB1	0.27620030
98	FER	0.27128101
99	IGF1R	0.26467825
100	ERBB4	0.26292841

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	3.53693391
2	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.34217823
3	Dilated cardiomyopathy_Homo sapiens_hsa05414	3.00609229
4	Other glycan degradation_Homo sapiens_hsa00511	2.87706079
5	Circadian rhythm_Homo sapiens_hsa04710	2.80680663
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.47694200
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.37847986
8	Insulin secretion_Homo sapiens_hsa04911	2.36227692
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.28758094
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.05312928
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.01581727
12	Olfactory transduction_Homo sapiens_hsa04740	1.99439980
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92663556
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85319042
15	Protein digestion and absorption_Homo sapiens_hsa04974	1.81902471
16	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.80916676
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.74092280
18	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.69763181
19	Sphingolipid metabolism_Homo sapiens_hsa00600	1.59563281
20	Glutathione metabolism_Homo sapiens_hsa00480	1.48252250
21	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.44680642
22	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.41967331
23	Peroxisome_Homo sapiens_hsa04146	1.39248602
24	Pancreatic secretion_Homo sapiens_hsa04972	1.38430138
25	Protein export_Homo sapiens_hsa03060	1.36956433
26	Folate biosynthesis_Homo sapiens_hsa00790	1.36059554
27	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.32838691
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.23395307
29	Lysosome_Homo sapiens_hsa04142	1.22458436
30	Mineral absorption_Homo sapiens_hsa04978	1.22346781
31	Complement and coagulation cascades_Homo sapiens_hsa04610	1.19274117
32	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.16106231
33	Glucagon signaling pathway_Homo sapiens_hsa04922	1.12299473
34	Fat digestion and absorption_Homo sapiens_hsa04975	1.12070679
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.09338843
36	Amphetamine addiction_Homo sapiens_hsa05031	1.06076707
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05388347
38	Sulfur metabolism_Homo sapiens_hsa00920	0.96659438
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93410061
40	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.88287593
41	Retinol metabolism_Homo sapiens_hsa00830	0.86595069
42	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.83913620
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82910683
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82121442
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.80359638
46	Basal cell carcinoma_Homo sapiens_hsa05217	0.78817510
47	Butanoate metabolism_Homo sapiens_hsa00650	0.77513513
48	Melanogenesis_Homo sapiens_hsa04916	0.76687297
49	Glioma_Homo sapiens_hsa05214	0.76404717
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.76325859
51	Circadian entrainment_Homo sapiens_hsa04713	0.73445113
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.71632906
53	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.71559598
54	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.70270388
55	Histidine metabolism_Homo sapiens_hsa00340	0.69954846
56	Gastric acid secretion_Homo sapiens_hsa04971	0.69169750
57	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.68812585
58	ErbB signaling pathway_Homo sapiens_hsa04012	0.68362366
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65207094
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.64091713
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.63762185
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.60109154
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59087168
64	Fatty acid degradation_Homo sapiens_hsa00071	0.58682369
65	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.55494408
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.54681239
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54061438
68	Linoleic acid metabolism_Homo sapiens_hsa00591	0.53485654
69	Oxidative phosphorylation_Homo sapiens_hsa00190	0.52869832
70	Legionellosis_Homo sapiens_hsa05134	0.49527597
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47796097
72	Proteoglycans in cancer_Homo sapiens_hsa05205	0.47609159
73	Regulation of autophagy_Homo sapiens_hsa04140	0.47468768
74	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46540336
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46267105
76	MicroRNAs in cancer_Homo sapiens_hsa05206	0.45739619
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45398077
78	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.45237821
79	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44830221
80	Cholinergic synapse_Homo sapiens_hsa04725	0.44471503
81	Tight junction_Homo sapiens_hsa04530	0.43632427
82	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43191364
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42644451
84	ECM-receptor interaction_Homo sapiens_hsa04512	0.41344844
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40301191
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39882934
87	Nitrogen metabolism_Homo sapiens_hsa00910	0.38887456
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38144779
89	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.38127392
90	Axon guidance_Homo sapiens_hsa04360	0.37045599
91	MAPK signaling pathway_Homo sapiens_hsa04010	0.36823757
92	Nicotine addiction_Homo sapiens_hsa05033	0.33182662
93	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.32655921
94	Focal adhesion_Homo sapiens_hsa04510	0.31812126
95	Metabolic pathways_Homo sapiens_hsa01100	0.31585538
96	FoxO signaling pathway_Homo sapiens_hsa04068	0.30882292
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30289541
98	Alzheimers disease_Homo sapiens_hsa05010	0.29725461
99	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.29451838
100	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.28475759

ANKRD26P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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