ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	plasma membrane fusion (GO:0045026)	9.31752401
2	sperm capacitation (GO:0048240)	8.37725897
3	spermatid development (GO:0007286)	8.20694511
4	multicellular organism reproduction (GO:0032504)	8.19130893
5	sperm-egg recognition (GO:0035036)	8.01548963
6	response to pheromone (GO:0019236)	7.71016434
7	DNA packaging (GO:0006323)	7.63173884
8	chromosome condensation (GO:0030261)	7.63005465
9	single strand break repair (GO:0000012)	7.60300051
10	binding of sperm to zona pellucida (GO:0007339)	7.48488335
11	microtubule depolymerization (GO:0007019)	7.43658840
12	reproduction (GO:0000003)	7.22805717
13	rRNA methylation (GO:0031167)	7.05453261
14	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.99620730
15	protein targeting to Golgi (GO:0000042)	6.75738827
16	microtubule severing (GO:0051013)	6.71572406
17	cell-cell recognition (GO:0009988)	6.63341541
18	calcium ion-dependent exocytosis (GO:0017156)	6.59751444
19	spermatid nucleus differentiation (GO:0007289)	6.54572130
20	phosphatidylethanolamine metabolic process (GO:0046337)	6.51661953
21	establishment of protein localization to Golgi (GO:0072600)	6.46752865
22	protein polyglutamylation (GO:0018095)	6.42936817
23	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.28779248
24	negative regulation of inclusion body assembly (GO:0090084)	6.28378867
25	spermatogenesis (GO:0007283)	6.09862661
26	male gamete generation (GO:0048232)	6.07780633
27	microtubule polymerization or depolymerization (GO:0031109)	6.04957231
28	rRNA modification (GO:0000154)	5.89577447
29	axonemal dynein complex assembly (GO:0070286)	5.81802839
30	sexual reproduction (GO:0019953)	5.64766757
31	gamete generation (GO:0007276)	5.63066739
32	single fertilization (GO:0007338)	5.43038066
33	centriole replication (GO:0007099)	5.20022461
34	regulation of cilium movement (GO:0003352)	5.19483735
35	regulation of Rab GTPase activity (GO:0032313)	4.99374167
36	positive regulation of Rab GTPase activity (GO:0032851)	4.99374167
37	protein localization to Golgi apparatus (GO:0034067)	4.96673744
38	germ cell development (GO:0007281)	4.94236645
39	cellular ketone body metabolic process (GO:0046950)	4.88080574
40	centriole assembly (GO:0098534)	4.80474771
41	regulation of transcription involved in cell fate commitment (GO:0060850)	4.80463071
42	response to acidic pH (GO:0010447)	4.75997116
43	cilium or flagellum-dependent cell motility (GO:0001539)	4.70761750
44	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.60585125
45	male meiosis I (GO:0007141)	4.57101163
46	fertilization (GO:0009566)	4.54220403
47	multicellular organismal reproductive process (GO:0048609)	4.50792279
48	male meiosis (GO:0007140)	4.47755083
49	epithelial cilium movement (GO:0003351)	4.44369583
50	cell wall macromolecule metabolic process (GO:0044036)	4.35698082
51	regulation of inclusion body assembly (GO:0090083)	4.33884745
52	motile cilium assembly (GO:0044458)	4.33215821
53	cell wall macromolecule catabolic process (GO:0016998)	4.32183247
54	ketone body metabolic process (GO:1902224)	4.29301540
55	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.18392300
56	Golgi to endosome transport (GO:0006895)	4.11060524
57	seminiferous tubule development (GO:0072520)	3.99441839
58	regulation of meiosis I (GO:0060631)	3.97468289
59	RNA destabilization (GO:0050779)	3.96769485
60	organic cation transport (GO:0015695)	3.95807377
61	regulation of centriole replication (GO:0046599)	3.84144350
62	cilium movement (GO:0003341)	3.80183820
63	piRNA metabolic process (GO:0034587)	3.70981322
64	meiosis I (GO:0007127)	3.55156049
65	histone H3-K9 demethylation (GO:0033169)	3.54829823
66	nucleus organization (GO:0006997)	3.52744714
67	coenzyme catabolic process (GO:0009109)	3.50899731
68	regulation of microtubule-based movement (GO:0060632)	3.42885948
69	synapsis (GO:0007129)	3.37696277
70	multicellular organismal movement (GO:0050879)	3.36302747
71	musculoskeletal movement (GO:0050881)	3.36302747
72	polyamine biosynthetic process (GO:0006596)	3.35710906
73	peptide catabolic process (GO:0043171)	3.33078455
74	cerebral cortex neuron differentiation (GO:0021895)	3.31774077
75	chromatin silencing (GO:0006342)	3.30385786
76	chromosome organization involved in meiosis (GO:0070192)	3.28464941
77	DNA methylation involved in gamete generation (GO:0043046)	3.23818573
78	cellular response to pH (GO:0071467)	3.15336548
79	synaptonemal complex assembly (GO:0007130)	3.10317844
80	cell recognition (GO:0008037)	3.10059908
81	glycerol ether metabolic process (GO:0006662)	3.09343534
82	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.08302703
83	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.08302703
84	microtubule nucleation (GO:0007020)	3.05030183
85	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.04360075
86	multicellular organismal development (GO:0007275)	3.03194249
87	peptidyl-threonine dephosphorylation (GO:0035970)	3.02229316
88	oocyte development (GO:0048599)	2.96949105
89	positive regulation of endothelial cell differentiation (GO:0045603)	2.96820082
90	meiotic nuclear division (GO:0007126)	2.96359007
91	positive regulation of guanylate cyclase activity (GO:0031284)	2.89376728
92	ether metabolic process (GO:0018904)	2.85622648
93	regulation of female gonad development (GO:2000194)	2.85310793
94	histone exchange (GO:0043486)	2.84802842
95	synaptonemal complex organization (GO:0070193)	2.84800695
96	positive regulation of meiotic cell cycle (GO:0051446)	2.82482914
97	protein depolymerization (GO:0051261)	2.79719970
98	fusion of sperm to egg plasma membrane (GO:0007342)	12.2113136
99	acrosome reaction (GO:0007340)	11.9871064
100	sperm motility (GO:0030317)	11.3731129

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.58570265
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.31800980
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.89557201
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.42832192
5	CBP_20019798_ChIP-Seq_JUKART_Human	2.40464810
6	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.40464810
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34715637
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.27715246
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23404938
10	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.22601762
11	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22601762
12	FUS_26573619_Chip-Seq_HEK293_Human	2.10995770
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.97243442
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.97133016
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.88007232
16	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.87982775
17	RAC3_21632823_ChIP-Seq_H3396_Human	1.85916671
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84595355
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.80202327
20	NANOG_20526341_ChIP-Seq_ESCs_Human	1.78162485
21	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.76493309
22	ERA_21632823_ChIP-Seq_H3396_Human	1.75882041
23	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.75645644
24	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.71380281
25	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.66639946
26	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.66534779
27	AR_25329375_ChIP-Seq_VCAP_Human	1.64086039
28	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.62247434
29	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.60471742
30	MYC_19829295_ChIP-Seq_ESCs_Human	1.60469146
31	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.58029260
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.57041076
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54883428
34	RBPJ_21746931_ChIP-Seq_IB4_Human	1.54191801
35	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52293683
36	OCT4_20526341_ChIP-Seq_ESCs_Human	1.50500346
37	ETV1_20927104_ChIP-Seq_GIST48_Human	1.50080067
38	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.49912671
39	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.47960298
40	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.46579349
41	P300_19829295_ChIP-Seq_ESCs_Human	1.46308492
42	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.43433071
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42784076
44	ERG_20517297_ChIP-Seq_VCAP_Human	1.41570728
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40283988
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.39572468
47	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.38522027
48	NFYB_21822215_ChIP-Seq_K562_Human	1.37982481
49	TBL1_22424771_ChIP-Seq_293T_Human	1.37549800
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36716719
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36421052
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36421052
53	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.35696815
54	CTCF_27219007_Chip-Seq_Bcells_Human	1.35573608
55	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.35428173
56	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.35180075
57	E2F1_20622854_ChIP-Seq_HELA_Human	1.34970224
58	AR_21572438_ChIP-Seq_LNCaP_Human	1.33188924
59	PHF8_20622853_ChIP-Seq_HELA_Human	1.33017741
60	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.30475723
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30352277
62	BCL6_27268052_Chip-Seq_Bcells_Human	1.29297557
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29085221
64	DROSHA_22980978_ChIP-Seq_HELA_Human	1.28580835
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26591330
66	SMRT_27268052_Chip-Seq_Bcells_Human	1.25989294
67	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.25986975
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25714809
69	ZNF274_21170338_ChIP-Seq_K562_Hela	1.24579050
70	TP53_18474530_ChIP-ChIP_U2OS_Human	1.24457431
71	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.23384071
72	PHF8_20622854_ChIP-Seq_HELA_Human	1.22637478
73	CTCF_20526341_ChIP-Seq_ESCs_Human	1.21850950
74	SMC4_20622854_ChIP-Seq_HELA_Human	1.21318582
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.20871640
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20247427
77	P300_27268052_Chip-Seq_Bcells_Human	1.20060640
78	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.18689030
79	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.17524398
80	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.17264827
81	STAT3_23295773_ChIP-Seq_U87_Human	1.17195142
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16096912
83	NFYA_21822215_ChIP-Seq_K562_Human	1.15351758
84	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.14134476
85	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.13168948
86	TP63_22573176_ChIP-Seq_HFKS_Human	1.12364409
87	CEBPB_22108803_ChIP-Seq_LS180_Human	1.12111935
88	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10410088
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09772807
90	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09508076
91	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.09427602
92	BCOR_27268052_Chip-Seq_Bcells_Human	1.09323776
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08855978
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08855978
95	GBX2_23144817_ChIP-Seq_PC3_Human	1.08427578
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.07269738
97	VDR_22108803_ChIP-Seq_LS180_Human	1.05800677
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05652378
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05381176
100	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.03491840

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	4.84430297
2	MP0005377_hearing/vestibular/ear_phenot	4.84430297
3	MP0003698_abnormal_male_reproductive	4.56305108
4	MP0001929_abnormal_gametogenesis	4.19018654
5	MP0005670_abnormal_white_adipose	4.17225651
6	MP0002161_abnormal_fertility/fecundity	2.51207153
7	MP0005379_endocrine/exocrine_gland_phen	2.44904730
8	MP0002210_abnormal_sex_determination	2.39080313
9	MP0005451_abnormal_body_composition	2.28267737
10	MP0000678_abnormal_parathyroid_gland	2.20980602
11	MP0001348_abnormal_lacrimal_gland	2.15877266
12	MP0003718_maternal_effect	2.15833387
13	MP0009697_abnormal_copulation	2.02588302
14	MP0005410_abnormal_fertilization	11.9963387
15	MP0001145_abnormal_male_reproductive	1.90799931
16	MP0000653_abnormal_sex_gland	1.86344745
17	MP0008877_abnormal_DNA_methylation	1.73350235
18	MP0003011_delayed_dark_adaptation	1.68569212
19	MP0002132_abnormal_respiratory_system	1.67887307
20	MP0005423_abnormal_somatic_nervous	1.45439935
21	MP0004510_myositis	1.41086169
22	MP0001485_abnormal_pinna_reflex	1.37461379
23	MP0003646_muscle_fatigue	1.30429155
24	MP0001765_abnormal_ion_homeostasis	1.29978880
25	MP0002138_abnormal_hepatobiliary_system	1.25885758
26	MP0005310_abnormal_salivary_gland	1.23884678
27	MP0001486_abnormal_startle_reflex	1.22094573
28	MP0003879_abnormal_hair_cell	1.21901587
29	MP0002822_catalepsy	1.21442269
30	MP0010386_abnormal_urinary_bladder	1.20992465
31	MP0008995_early_reproductive_senescence	1.20137605
32	MP0005666_abnormal_adipose_tissue	1.14027021
33	MP0002234_abnormal_pharynx_morphology	1.13149604
34	MP0002735_abnormal_chemical_nociception	1.08993075
35	MP0001963_abnormal_hearing_physiology	1.05485610
36	MP0004742_abnormal_vestibular_system	1.05409217
37	MP0005395_other_phenotype	1.05152170
38	MP0008004_abnormal_stomach_pH	1.03820277
39	MP0001440_abnormal_grooming_behavior	1.02585758
40	MP0001984_abnormal_olfaction	1.02439740
41	MP0002163_abnormal_gland_morphology	1.01995361
42	MP0002160_abnormal_reproductive_system	0.99963736
43	MP0001905_abnormal_dopamine_level	0.97988751
44	MP0001879_abnormal_lymphatic_vessel	0.97465616
45	MP0005551_abnormal_eye_electrophysiolog	0.96821875
46	MP0000534_abnormal_ureter_morphology	0.95706655
47	MP0001968_abnormal_touch/_nociception	0.95182443
48	MP0005375_adipose_tissue_phenotype	0.93882009
49	MP0000026_abnormal_inner_ear	0.91788672
50	MP0002229_neurodegeneration	0.88168041
51	MP0005253_abnormal_eye_physiology	0.87990939
52	MP0004085_abnormal_heartbeat	0.86347806
53	MP0010368_abnormal_lymphatic_system	0.82387976
54	MP0002102_abnormal_ear_morphology	0.81020541
55	MP0002249_abnormal_larynx_morphology	0.79270325
56	MP0009053_abnormal_anal_canal	0.79103260
57	MP0000003_abnormal_adipose_tissue	0.77907327
58	MP0002282_abnormal_trachea_morphology	0.76500059
59	MP0004019_abnormal_vitamin_homeostasis	0.76147077
60	MP0005167_abnormal_blood-brain_barrier	0.76080215
61	MP0002127_abnormal_cardiovascular_syste	0.75477145
62	MP0005647_abnormal_sex_gland	0.74319608
63	MP0003806_abnormal_nucleotide_metabolis	0.72256273
64	MP0003880_abnormal_central_pattern	0.71438669
65	MP0005636_abnormal_mineral_homeostasis	0.71137444
66	MP0004036_abnormal_muscle_relaxation	0.67018204
67	MP0000681_abnormal_thyroid_gland	0.66919009
68	MP0001756_abnormal_urination	0.66030377
69	MP0002067_abnormal_sensory_capabilities	0.65619169
70	MP0003183_abnormal_peptide_metabolism	0.64138891
71	MP0001119_abnormal_female_reproductive	0.63804071
72	MP0009115_abnormal_fat_cell	0.63728065
73	MP0003699_abnormal_female_reproductive	0.62826009
74	MP0005248_abnormal_Harderian_gland	0.60405543
75	MP0005084_abnormal_gallbladder_morpholo	0.57959714
76	MP0004484_altered_response_of	0.56875372
77	MP0001666_abnormal_nutrient_absorption	0.56874818
78	MP0005535_abnormal_body_temperature	0.55402464
79	MP0009745_abnormal_behavioral_response	0.54836176
80	MP0000230_abnormal_systemic_arterial	0.54557243
81	MP0002572_abnormal_emotion/affect_behav	0.54297693
82	MP0002272_abnormal_nervous_system	0.52546286
83	MP0000049_abnormal_middle_ear	0.52263379
84	MP0002557_abnormal_social/conspecific_i	0.51193413
85	MP0004859_abnormal_synaptic_plasticity	0.50303323
86	MP0003936_abnormal_reproductive_system	0.49602642
87	MP0005389_reproductive_system_phenotype	0.49568919
88	MP0000516_abnormal_urinary_system	0.48987356
89	MP0005367_renal/urinary_system_phenotyp	0.48987356
90	MP0005332_abnormal_amino_acid	0.46793454
91	MP0009046_muscle_twitch	0.46791979
92	MP0003195_calcinosis	0.46650257
93	MP0000955_abnormal_spinal_cord	0.45558785
94	MP0000613_abnormal_salivary_gland	0.45062358
95	MP0009780_abnormal_chondrocyte_physiolo	0.44051671
96	MP0003633_abnormal_nervous_system	0.43675422
97	MP0003631_nervous_system_phenotype	0.42772645
98	MP0001944_abnormal_pancreas_morphology	0.42211496
99	MP0005408_hypopigmentation	0.41071439
100	MP0004084_abnormal_cardiac_muscle	0.40976916

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.56452366
2	Absent/shortened dynein arms (HP:0200106)	5.13635488
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.13635488
4	Tubulointerstitial nephritis (HP:0001970)	4.75812990
5	Bony spicule pigmentary retinopathy (HP:0007737)	4.65721652
6	Resting tremor (HP:0002322)	4.64893448
7	Attenuation of retinal blood vessels (HP:0007843)	4.59410623
8	Asymmetric septal hypertrophy (HP:0001670)	4.53717402
9	Osteomalacia (HP:0002749)	4.48660165
10	Abnormal ciliary motility (HP:0012262)	4.44819379
11	Male infertility (HP:0003251)	4.42348422
12	Abnormal respiratory motile cilium physiology (HP:0012261)	4.41113044
13	Enlarged epiphyses (HP:0010580)	4.27689131
14	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.27605284
15	Abnormal rod and cone electroretinograms (HP:0008323)	4.23526586
16	Infertility (HP:0000789)	4.15606181
17	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.08079189
18	Abnormal respiratory epithelium morphology (HP:0012253)	4.04677174
19	Abnormal respiratory motile cilium morphology (HP:0005938)	4.04677174
20	Bell-shaped thorax (HP:0001591)	3.91607893
21	Abnormality of macular pigmentation (HP:0008002)	3.91330391
22	Hypoplastic ischia (HP:0003175)	3.74262999
23	Renal Fanconi syndrome (HP:0001994)	3.70027820
24	Chronic hepatic failure (HP:0100626)	3.68368136
25	Potter facies (HP:0002009)	3.47838886
26	Facial shape deformation (HP:0011334)	3.47838886
27	Hyperkalemia (HP:0002153)	3.36583921
28	Nasal polyposis (HP:0100582)	3.30344536
29	Abnormal spermatogenesis (HP:0008669)	3.23895205
30	Abnormality of the ischium (HP:0003174)	3.23352673
31	Cone-rod dystrophy (HP:0000548)	3.21767527
32	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.12969785
33	Azoospermia (HP:0000027)	3.12082359
34	Hypoplasia of the thymus (HP:0000778)	3.00311835
35	Nephronophthisis (HP:0000090)	2.97944809
36	Postural instability (HP:0002172)	2.95499821
37	Hypophosphatemic rickets (HP:0004912)	2.87297162
38	Abnormality of the costochondral junction (HP:0000919)	2.82574800
39	Rhinitis (HP:0012384)	2.81919369
40	Abnormality of the nasal mucosa (HP:0000433)	2.76150795
41	Atelectasis (HP:0100750)	2.75577838
42	Impulsivity (HP:0100710)	2.73299355
43	Portal hypertension (HP:0001409)	2.64816162
44	Rickets (HP:0002748)	2.62380786
45	Polydipsia (HP:0001959)	2.62167743
46	Abnormal drinking behavior (HP:0030082)	2.62167743
47	Abnormal urine output (HP:0012590)	2.59490714
48	Abnormality of renal resorption (HP:0011038)	2.59338849
49	Abnormality of potassium homeostasis (HP:0011042)	2.45865167
50	Abnormality of the hepatic vasculature (HP:0006707)	2.45559243
51	Stage 5 chronic kidney disease (HP:0003774)	2.39454870
52	Protuberant abdomen (HP:0001538)	2.38589750
53	Abnormality of the renal medulla (HP:0100957)	2.36319377
54	Tubulointerstitial abnormality (HP:0001969)	2.35186784
55	Insulin-resistant diabetes mellitus (HP:0000831)	2.35089127
56	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.33491899
57	Abnormality of renal excretion (HP:0011036)	2.31621046
58	Amelogenesis imperfecta (HP:0000705)	2.31239732
59	Menstrual irregularities (HP:0000858)	2.29781649
60	Hyponatremia (HP:0002902)	2.28490759
61	Abnormality of dental color (HP:0011073)	2.28073958
62	Short ribs (HP:0000773)	2.26427624
63	Sensory axonal neuropathy (HP:0003390)	2.19969777
64	Unilateral renal agenesis (HP:0000122)	2.19358451
65	Polyuria (HP:0000103)	2.16661107
66	Generalized aminoaciduria (HP:0002909)	2.16071094
67	Decreased central vision (HP:0007663)	2.15480228
68	Congenital malformation of the right heart (HP:0011723)	2.14144686
69	Double outlet right ventricle (HP:0001719)	2.14144686
70	Progressive cerebellar ataxia (HP:0002073)	2.13552721
71	Median cleft lip (HP:0000161)	2.13261880
72	Bulbous nose (HP:0000414)	2.10132244
73	Widely patent fontanelles and sutures (HP:0004492)	2.09830592
74	Chronic bronchitis (HP:0004469)	2.03303357
75	Bronchiectasis (HP:0002110)	2.00586060
76	Hypoalphalipoproteinemia (HP:0003233)	2.00350203
77	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.00061461
78	Progressive sensorineural hearing impairment (HP:0000408)	2.00025332
79	Renal dysplasia (HP:0000110)	1.97501137
80	Buphthalmos (HP:0000557)	1.92461348
81	Truncal obesity (HP:0001956)	1.91279139
82	Hypokalemia (HP:0002900)	1.90898876
83	Neoplasm of the oral cavity (HP:0100649)	1.88896682
84	Scotoma (HP:0000575)	1.83710273
85	Abnormality of sodium homeostasis (HP:0010931)	1.83502810
86	Recurrent pneumonia (HP:0006532)	1.82435466
87	Glycosuria (HP:0003076)	1.78818530
88	Abnormality of urine glucose concentration (HP:0011016)	1.78818530
89	Mixed hearing impairment (HP:0000410)	1.78326916
90	Abnormality of lateral ventricle (HP:0030047)	1.76689045
91	Congenital sensorineural hearing impairment (HP:0008527)	1.76164711
92	Abnormality of dentin (HP:0010299)	1.72598238
93	Hyperphosphaturia (HP:0003109)	1.71115686
94	Gingivitis (HP:0000230)	1.68079327
95	Increased purine levels (HP:0004368)	1.66642046
96	Hyperuricemia (HP:0002149)	1.66642046
97	Photophobia (HP:0000613)	1.65333824
98	Metaphyseal dysplasia (HP:0100255)	1.64454286
99	Hyperthyroidism (HP:0000836)	1.62113728
100	Ventricular tachycardia (HP:0004756)	1.61554050

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.86168288
2	TESK1	5.52673563
3	DDR2	4.76755862
4	INSRR	3.89978500
5	STK38	3.37257088
6	MAP4K2	3.01915305
7	PLK2	2.97679897
8	PNCK	2.91453780
9	STK38L	2.54915930
10	PINK1	2.26969344
11	PIK3CG	2.24395699
12	BRD4	2.02614443
13	MAPK15	1.98871629
14	CAMK1G	1.92515223
15	PTK2B	1.86260917
16	MST1R	1.63459359
17	WNK1	1.59934139
18	FRK	1.43440526
19	LATS1	1.38409809
20	PDPK1	1.35823031
21	PDK1	1.29804988
22	MAP3K2	1.23344045
23	PRKD3	1.17717896
24	WNK4	1.15070705
25	CDK7	1.08866707
26	NEK6	1.05802717
27	PRKG2	0.99021026
28	MARK3	0.95003240
29	STK39	0.91096675
30	TLK1	0.90775220
31	DYRK1B	0.90430661
32	TIE1	0.80633156
33	RIPK4	0.80022531
34	PRKG1	0.79957747
35	TRIM28	0.77581886
36	MAP3K11	0.74778184
37	UHMK1	0.74213714
38	CDK12	0.72826927
39	RPS6KA2	0.71464514
40	MYLK	0.70557013
41	CDK3	0.69202686
42	AKT3	0.65392045
43	RPS6KA1	0.64660821
44	CAMK1	0.61893433
45	NTRK3	0.60854625
46	SGK223	0.58374037
47	SGK494	0.58374037
48	MAP2K2	0.55769043
49	MET	0.55019229
50	BRSK2	0.50701254
51	OXSR1	0.49947770
52	CAMKK2	0.49556739
53	RPS6KA6	0.49283249
54	ROCK1	0.47620648
55	RPS6KL1	0.44190362
56	RPS6KC1	0.44190362
57	CDK19	0.42635991
58	PRKAA2	0.42618039
59	TRPM7	0.41585036
60	TNIK	0.41223565
61	CAMK4	0.39166764
62	PRKCE	0.38949868
63	RPS6KA5	0.38498202
64	SGK1	0.37381362
65	CAMK1D	0.37246585
66	FER	0.34992858
67	MAP3K1	0.34606231
68	NUAK1	0.34419927
69	MAP3K12	0.34261212
70	LATS2	0.33565218
71	MUSK	0.32835882
72	MAP3K9	0.32589998
73	BRAF	0.32166784
74	MAPK1	0.32008918
75	BMPR1B	0.31848663
76	CDK2	0.29573146
77	SGK2	0.29042779
78	ZAK	0.27047621
79	GSK3B	0.26864472
80	PRKCG	0.26779765
81	IKBKB	0.26332539
82	YES1	0.25959796
83	TESK2	0.25741607
84	BRSK1	0.24882092
85	PASK	0.23265071
86	PRKCB	0.22342770
87	PRKCZ	0.22102100
88	KIT	0.21954761
89	STK3	0.21418048
90	CDK1	0.20712677
91	CHEK1	0.19956709
92	DYRK3	0.19687010
93	DYRK2	0.19336394
94	MAP3K4	0.19032168
95	PRKCQ	0.17705661
96	JAK3	0.16802185
97	KSR2	0.16223908
98	PRKACA	0.16125811
99	TEC	0.15003162
100	NLK	0.14932034

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.49680728
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.62675094
3	Olfactory transduction_Homo sapiens_hsa04740	3.68226086
4	Butanoate metabolism_Homo sapiens_hsa00650	2.82340053
5	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.37646404
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.16828253
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.09535377
8	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.03696226
9	Type I diabetes mellitus_Homo sapiens_hsa04940	1.98423956
10	Taste transduction_Homo sapiens_hsa04742	1.94327181
11	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.88715471
12	RNA transport_Homo sapiens_hsa03013	1.60155211
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.59707176
14	Oocyte meiosis_Homo sapiens_hsa04114	1.57907638
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.56450881
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.53716856
17	Allograft rejection_Homo sapiens_hsa05330	1.51457511
18	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.45166712
19	Regulation of autophagy_Homo sapiens_hsa04140	1.44302322
20	Fatty acid degradation_Homo sapiens_hsa00071	1.44088567
21	ABC transporters_Homo sapiens_hsa02010	1.27949042
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.27344997
23	Type II diabetes mellitus_Homo sapiens_hsa04930	1.26575276
24	Renin secretion_Homo sapiens_hsa04924	1.25936744
25	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.25433925
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19748687
27	Fatty acid metabolism_Homo sapiens_hsa01212	1.15701907
28	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.11394635
29	Phenylalanine metabolism_Homo sapiens_hsa00360	1.09546583
30	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.06710282
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.04860174
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.03276083
33	Salivary secretion_Homo sapiens_hsa04970	1.00315673
34	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.96576203
35	Endocytosis_Homo sapiens_hsa04144	0.91861306
36	Arginine biosynthesis_Homo sapiens_hsa00220	0.91642343
37	Selenocompound metabolism_Homo sapiens_hsa00450	0.86779589
38	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.86665377
39	Phototransduction_Homo sapiens_hsa04744	0.86104512
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81380584
41	Basal transcription factors_Homo sapiens_hsa03022	0.81227304
42	Protein digestion and absorption_Homo sapiens_hsa04974	0.81002081
43	Morphine addiction_Homo sapiens_hsa05032	0.80575400
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.80005275
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78924814
46	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.77071242
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77019123
48	Circadian entrainment_Homo sapiens_hsa04713	0.76385742
49	Purine metabolism_Homo sapiens_hsa00230	0.72891781
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68769411
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67735770
52	Long-term potentiation_Homo sapiens_hsa04720	0.67702729
53	PPAR signaling pathway_Homo sapiens_hsa03320	0.66928153
54	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.66872399
55	Amphetamine addiction_Homo sapiens_hsa05031	0.66628560
56	Viral myocarditis_Homo sapiens_hsa05416	0.66441887
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63458026
58	VEGF signaling pathway_Homo sapiens_hsa04370	0.63306264
59	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.60502750
60	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.60294232
61	Renin-angiotensin system_Homo sapiens_hsa04614	0.59012775
62	Retinol metabolism_Homo sapiens_hsa00830	0.57675253
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.57467272
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56738337
65	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.56337735
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56330258
67	Influenza A_Homo sapiens_hsa05164	0.56077336
68	Insulin secretion_Homo sapiens_hsa04911	0.55223917
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54914732
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.51871504
71	Gap junction_Homo sapiens_hsa04540	0.51702231
72	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.49940489
73	Serotonergic synapse_Homo sapiens_hsa04726	0.48296972
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47756293
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.46575070
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.45575744
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.44287325
78	Glutathione metabolism_Homo sapiens_hsa00480	0.42467332
79	Huntingtons disease_Homo sapiens_hsa05016	0.42370933
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42296069
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41084182
82	MAPK signaling pathway_Homo sapiens_hsa04010	0.39890556
83	Cholinergic synapse_Homo sapiens_hsa04725	0.38493515
84	Gastric acid secretion_Homo sapiens_hsa04971	0.37971176
85	Phagosome_Homo sapiens_hsa04145	0.37572948
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35544775
87	mRNA surveillance pathway_Homo sapiens_hsa03015	0.34468309
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.33212093
89	Propanoate metabolism_Homo sapiens_hsa00640	0.33096619
90	Mineral absorption_Homo sapiens_hsa04978	0.32868639
91	Alcoholism_Homo sapiens_hsa05034	0.32182706
92	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.31910053
93	ECM-receptor interaction_Homo sapiens_hsa04512	0.31611818
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30873130
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30752760
96	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.30717574
97	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30566173
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30096444
99	Tight junction_Homo sapiens_hsa04530	0.29646917
100	Platelet activation_Homo sapiens_hsa04611	0.28089237

ANKRD30BP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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