ANKRD34A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.32362747
2synaptic vesicle maturation (GO:0016188)6.15018899
3locomotory exploration behavior (GO:0035641)5.96928631
4vocalization behavior (GO:0071625)5.86169753
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.85180917
6synaptic vesicle exocytosis (GO:0016079)5.65553147
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.57947330
8glutamate secretion (GO:0014047)5.55740696
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55612200
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.44462181
11regulation of synaptic vesicle exocytosis (GO:2000300)5.23140517
12regulation of glutamate receptor signaling pathway (GO:1900449)5.18984046
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.92104321
14protein localization to synapse (GO:0035418)4.85808866
15neuronal action potential propagation (GO:0019227)4.77052954
16regulation of synaptic vesicle transport (GO:1902803)4.69236292
17exploration behavior (GO:0035640)4.68446473
18neurotransmitter secretion (GO:0007269)4.64505475
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.59707255
20regulation of neuronal synaptic plasticity (GO:0048168)4.56436964
21neuron cell-cell adhesion (GO:0007158)4.44820605
22synaptic transmission, glutamatergic (GO:0035249)4.43099572
23glutamate receptor signaling pathway (GO:0007215)4.39686890
24L-amino acid import (GO:0043092)4.38305220
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33439237
26potassium ion homeostasis (GO:0055075)4.28057971
27amino acid import (GO:0043090)4.26185970
28regulation of synapse structural plasticity (GO:0051823)4.18711365
29neuron-neuron synaptic transmission (GO:0007270)4.17711521
30neurotransmitter-gated ion channel clustering (GO:0072578)4.14481861
31dendritic spine morphogenesis (GO:0060997)4.08298891
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03730025
33layer formation in cerebral cortex (GO:0021819)4.01708684
34regulation of synapse maturation (GO:0090128)4.00490139
35long-term memory (GO:0007616)3.98957982
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98811884
37cellular potassium ion homeostasis (GO:0030007)3.97784243
38positive regulation of membrane potential (GO:0045838)3.93275495
39gamma-aminobutyric acid transport (GO:0015812)3.92841022
40regulation of ARF protein signal transduction (GO:0032012)3.92205571
41potassium ion import (GO:0010107)3.88469423
42positive regulation of synapse maturation (GO:0090129)3.83783004
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83153875
44regulation of postsynaptic membrane potential (GO:0060078)3.83022957
45sodium ion export (GO:0071436)3.74795358
46regulation of synaptic plasticity (GO:0048167)3.74735988
47negative regulation of dendrite morphogenesis (GO:0050774)3.73725369
48neurotransmitter transport (GO:0006836)3.73090833
49regulation of dendritic spine morphogenesis (GO:0061001)3.65393281
50proline transport (GO:0015824)3.60676335
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.59359866
52cell communication by electrical coupling (GO:0010644)3.58610365
53negative regulation of neurotransmitter secretion (GO:0046929)3.57907595
54long-term synaptic potentiation (GO:0060291)3.57489145
55activation of protein kinase A activity (GO:0034199)3.55793262
56cerebellar Purkinje cell differentiation (GO:0021702)3.55190123
57synaptic vesicle endocytosis (GO:0048488)3.54937609
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.52133855
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52036083
60regulation of neurotransmitter secretion (GO:0046928)3.51593504
61cellular sodium ion homeostasis (GO:0006883)3.50103060
62regulation of neurotransmitter levels (GO:0001505)3.49044638
63neuromuscular process controlling posture (GO:0050884)3.48279096
64neuromuscular process controlling balance (GO:0050885)3.46074881
65neuron recognition (GO:0008038)3.43003792
66regulation of vesicle fusion (GO:0031338)3.39330331
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.39182747
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.38502764
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35440472
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.34880507
71transmission of nerve impulse (GO:0019226)3.34172717
72positive regulation of neurotransmitter transport (GO:0051590)3.29364132
73positive regulation of neurotransmitter secretion (GO:0001956)3.28178442
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27592285
75membrane depolarization (GO:0051899)3.27319878
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.25693701
77postsynaptic membrane organization (GO:0001941)3.25446837
78regulation of neurotransmitter transport (GO:0051588)3.25076759
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23812497
80auditory behavior (GO:0031223)3.22972803
81cerebellar granule cell differentiation (GO:0021707)3.22635576
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.22170951
83response to histamine (GO:0034776)3.18632320
84membrane depolarization during action potential (GO:0086010)3.17470446
85dicarboxylic acid transport (GO:0006835)3.16991058
86behavioral defense response (GO:0002209)3.16710676
87behavioral fear response (GO:0001662)3.16710676
88axonal fasciculation (GO:0007413)3.16446970
89cell migration in hindbrain (GO:0021535)3.16202176
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15486794
91positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12277798
92regulation of dendritic spine development (GO:0060998)3.11974560
93membrane hyperpolarization (GO:0060081)3.11774073
94neuronal ion channel clustering (GO:0045161)3.10626413
95neuromuscular synaptic transmission (GO:0007274)3.10059707
96chemosensory behavior (GO:0007635)3.09586796
97learning (GO:0007612)3.08500164
98detection of calcium ion (GO:0005513)3.08149915
99acidic amino acid transport (GO:0015800)3.07986805
100dendritic spine organization (GO:0097061)3.07508061
101cell differentiation in hindbrain (GO:0021533)3.07232298
102response to pheromone (GO:0019236)3.06991582
103positive regulation of synaptic transmission (GO:0050806)3.06938964
104vesicle docking involved in exocytosis (GO:0006904)3.06931974
105regulation of synaptic transmission (GO:0050804)3.06621430
106prepulse inhibition (GO:0060134)3.06431324
107innervation (GO:0060384)3.06224467
108synaptic transmission (GO:0007268)3.06152846
109regulation of voltage-gated calcium channel activity (GO:1901385)3.04448347
110acid secretion (GO:0046717)3.03562770
111positive regulation of dendritic spine development (GO:0060999)3.03093985
112fear response (GO:0042596)3.01354022
113social behavior (GO:0035176)3.01138025
114intraspecies interaction between organisms (GO:0051703)3.01138025
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.01092599
116signal release (GO:0023061)3.00726906
117response to auditory stimulus (GO:0010996)3.00443876
118neuromuscular process (GO:0050905)3.00265810
119synaptic vesicle transport (GO:0048489)2.98332362
120establishment of synaptic vesicle localization (GO:0097480)2.98332362
121behavioral response to cocaine (GO:0048148)2.96719475
122serotonin metabolic process (GO:0042428)2.95897926
123positive regulation of dendrite development (GO:1900006)2.90709199
124cerebellar Purkinje cell layer development (GO:0021680)2.87515244
125response to gravity (GO:0009629)2.87166831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.46494389
2GBX2_23144817_ChIP-Seq_PC3_Human3.38639770
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25094269
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.22316827
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22310818
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.03516449
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86922583
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86922583
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.82587955
10REST_21632747_ChIP-Seq_MESCs_Mouse2.81237557
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75701342
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72541675
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63219529
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60199414
15DROSHA_22980978_ChIP-Seq_HELA_Human2.59794982
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58029068
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54434685
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.52707183
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.34648316
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30408774
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.29009856
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.28837248
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24773443
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24086912
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.23187933
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22517749
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19941097
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07858939
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97043191
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94261807
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89089112
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87087311
33LXR_22292898_ChIP-Seq_THP-1_Human1.85683006
34AR_21572438_ChIP-Seq_LNCaP_Human1.78144618
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72377961
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.68586750
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68481438
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68204850
39TAF15_26573619_Chip-Seq_HEK293_Human1.65641848
40SMAD4_21799915_ChIP-Seq_A2780_Human1.64258337
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60951151
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60284974
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56994159
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.55332838
45CTCF_27219007_Chip-Seq_Bcells_Human1.53494632
46ZNF274_21170338_ChIP-Seq_K562_Hela1.43753600
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42033789
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.41469756
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41175702
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40582698
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36923939
52CREB1_26743006_Chip-Seq_LNCaP_Human1.36120182
53* KDM2B_26808549_Chip-Seq_DND41_Human1.34611438
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33997943
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33255485
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32767932
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32407539
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31459161
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.30851608
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30851604
61P300_19829295_ChIP-Seq_ESCs_Human1.28519592
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27508891
63* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26766449
64AR_19668381_ChIP-Seq_PC3_Human1.25290580
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24399888
66AR_25329375_ChIP-Seq_VCAP_Human1.23930946
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22879358
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.22698104
69P68_20966046_ChIP-Seq_HELA_Human1.22215525
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.21110218
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16438381
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16335581
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14014188
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13556161
75STAT3_23295773_ChIP-Seq_U87_Human1.13340638
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12987614
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12863331
78SMC4_20622854_ChIP-Seq_HELA_Human1.12748585
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.12654351
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.12033857
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11644849
82* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10739182
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.10208805
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09860959
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08863747
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08502064
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08210666
88* RING1B_27294783_Chip-Seq_NPCs_Mouse1.08097408
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.07444351
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06706526
91* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05987382
92KDM2B_26808549_Chip-Seq_K562_Human1.05258852
93OCT4_19829295_ChIP-Seq_ESCs_Human1.03621445
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03192769
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.02763656
96TCF4_23295773_ChIP-Seq_U87_Human1.02626727
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.02229831
98* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02134384
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02100400
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02039802
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01685861
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01276932
103STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01245187
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00315048
105TP53_23651856_ChIP-Seq_MEFs_Mouse0.99698255
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99212884
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99123893
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97685366
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96605386
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.96219468
111RNF2_27304074_Chip-Seq_NSC_Mouse0.95671108
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95588631
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.95425963
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95270890
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94445889
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.94415485
117TP53_16413492_ChIP-PET_HCT116_Human0.93757824
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93469703
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.92805530
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92670383
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92604145
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91829802
123AHR_22903824_ChIP-Seq_MCF-7_Human0.91761215
124RUNX2_22187159_ChIP-Seq_PCA_Human0.91259995
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90669150
126TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90486651
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.89861527
128PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89526361
129GATA1_26923725_Chip-Seq_HPCs_Mouse0.89121370
130RXR_22108803_ChIP-Seq_LS180_Human0.88723823
131* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88520117
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86745383
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86745383
134JUN_21703547_ChIP-Seq_K562_Human0.86700319
135MYC_19915707_ChIP-ChIP_AK7_Human0.86669335
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86539471
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85892610
138TCF7_22412390_ChIP-Seq_EML_Mouse0.85441070
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.85309607
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83019949
141FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82927505
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82890291
143VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81631273
144KLF4_19829295_ChIP-Seq_ESCs_Human0.81269049
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78215237
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77459768
147* DPY_21335234_ChIP-Seq_ESCs_Mouse0.76314661
148CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75823946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.95001251
2MP0003880_abnormal_central_pattern4.96602747
3MP0003635_abnormal_synaptic_transmissio4.34044165
4MP0004270_analgesia3.61487602
5MP0009745_abnormal_behavioral_response3.58714414
6MP0002063_abnormal_learning/memory/cond3.43821099
7MP0002064_seizures3.31266006
8MP0009046_muscle_twitch3.23119943
9MP0001968_abnormal_touch/_nociception2.90511799
10MP0002572_abnormal_emotion/affect_behav2.88350386
11MP0002822_catalepsy2.84632748
12MP0002272_abnormal_nervous_system2.68878472
13MP0005423_abnormal_somatic_nervous2.58672498
14MP0001486_abnormal_startle_reflex2.56577054
15MP0002734_abnormal_mechanical_nocicepti2.46372648
16MP0001501_abnormal_sleep_pattern2.40675784
17MP0002736_abnormal_nociception_after2.21951378
18MP0001440_abnormal_grooming_behavior2.15123458
19MP0002735_abnormal_chemical_nociception2.02341457
20MP0008569_lethality_at_weaning1.99589202
21MP0002067_abnormal_sensory_capabilities1.94301607
22MP0009780_abnormal_chondrocyte_physiolo1.94273664
23MP0003329_amyloid_beta_deposits1.94103050
24MP0002733_abnormal_thermal_nociception1.86341031
25MP0001970_abnormal_pain_threshold1.85946415
26MP0004145_abnormal_muscle_electrophysio1.85168852
27MP0002184_abnormal_innervation1.73809247
28MP0004858_abnormal_nervous_system1.70993119
29MP0002557_abnormal_social/conspecific_i1.70690933
30MP0004811_abnormal_neuron_physiology1.70355543
31MP0002909_abnormal_adrenal_gland1.68197647
32MP0005386_behavior/neurological_phenoty1.67502664
33MP0004924_abnormal_behavior1.67502664
34MP0005646_abnormal_pituitary_gland1.62401964
35MP0003879_abnormal_hair_cell1.60536033
36MP0000778_abnormal_nervous_system1.58482651
37MP0003787_abnormal_imprinting1.55160683
38MP0003122_maternal_imprinting1.53720355
39MP0006276_abnormal_autonomic_nervous1.52238538
40MP0002066_abnormal_motor_capabilities/c1.44366242
41MP0000955_abnormal_spinal_cord1.42019233
42MP0001984_abnormal_olfaction1.40948745
43MP0002882_abnormal_neuron_morphology1.35646963
44MP0003633_abnormal_nervous_system1.32914379
45MP0000751_myopathy1.30545682
46MP0001348_abnormal_lacrimal_gland1.27370821
47MP0001502_abnormal_circadian_rhythm1.26567204
48MP0001905_abnormal_dopamine_level1.26294405
49MP0004885_abnormal_endolymph1.25668569
50MP0004142_abnormal_muscle_tone1.20840773
51MP0001529_abnormal_vocalization1.20576110
52MP0002837_dystrophic_cardiac_calcinosis1.17471434
53MP0003631_nervous_system_phenotype1.14221509
54MP0001346_abnormal_lacrimal_gland1.13661768
55MP0004215_abnormal_myocardial_fiber1.10651218
56MP0002152_abnormal_brain_morphology1.08015888
57MP0005645_abnormal_hypothalamus_physiol1.07501929
58MP0004085_abnormal_heartbeat1.04767540
59MP0008872_abnormal_physiological_respon1.04202203
60MP0000013_abnormal_adipose_tissue1.01520799
61MP0002069_abnormal_eating/drinking_beha0.93453132
62MP0008874_decreased_physiological_sensi0.92583911
63MP0001177_atelectasis0.91950671
64MP0003137_abnormal_impulse_conducting0.90906080
65MP0002229_neurodegeneration0.90395145
66MP0003075_altered_response_to0.89629847
67MP0005551_abnormal_eye_electrophysiolog0.88719961
68MP0002653_abnormal_ependyma_morphology0.86524437
69MP0001188_hyperpigmentation0.85559170
70MP0004233_abnormal_muscle_weight0.84419005
71MP0004484_altered_response_of0.82557175
72MP0003632_abnormal_nervous_system0.82467979
73MP0000604_amyloidosis0.82262095
74MP0005623_abnormal_meninges_morphology0.81762224
75MP0004742_abnormal_vestibular_system0.81603965
76MP0005535_abnormal_body_temperature0.79721115
77MP0004510_myositis0.78294165
78MP0003690_abnormal_glial_cell0.75726173
79MP0003283_abnormal_digestive_organ0.75353177
80MP0000569_abnormal_digit_pigmentation0.74657353
81MP0003045_fibrosis0.73065972
82MP0001963_abnormal_hearing_physiology0.72325780
83MP0004036_abnormal_muscle_relaxation0.71676005
84MP0000920_abnormal_myelination0.71512906
85MP0003634_abnormal_glial_cell0.71143576
86MP0008961_abnormal_basal_metabolism0.70522255
87MP0003123_paternal_imprinting0.67494379
88MP0005394_taste/olfaction_phenotype0.66947400
89MP0005499_abnormal_olfactory_system0.66947400
90MP0004130_abnormal_muscle_cell0.66874649
91MP0002752_abnormal_somatic_nervous0.65993589
92MP0010386_abnormal_urinary_bladder0.64553198
93MP0002090_abnormal_vision0.63495145
94MP0000631_abnormal_neuroendocrine_gland0.60114422
95MP0003705_abnormal_hypodermis_morpholog0.57943300
96MP0000538_abnormal_urinary_bladder0.56795226
97MP0004147_increased_porphyrin_level0.56692390
98MP0005620_abnormal_muscle_contractility0.56669621
99MP0010768_mortality/aging0.56646447
100MP0001664_abnormal_digestion0.56494814
101MP0003172_abnormal_lysosome_physiology0.55393856
102MP0002638_abnormal_pupillary_reflex0.55056666
103MP0001943_abnormal_respiration0.53902883
104MP0002295_abnormal_pulmonary_circulatio0.53594768
105MP0010769_abnormal_survival0.53490825
106MP0001485_abnormal_pinna_reflex0.53450307
107MP0005167_abnormal_blood-brain_barrier0.52898583
108MP0000537_abnormal_urethra_morphology0.51649878
109MP0000747_muscle_weakness0.51203378
110MP0008877_abnormal_DNA_methylation0.50813510
111MP0002082_postnatal_lethality0.50716142
112MP0010770_preweaning_lethality0.50716142
113MP0005409_darkened_coat_color0.50325873
114MP0002009_preneoplasia0.48401926
115MP0003956_abnormal_body_size0.47666956
116MP0001299_abnormal_eye_distance/0.46562939
117MP0003861_abnormal_nervous_system0.46338967
118MP0000534_abnormal_ureter_morphology0.46022278
119MP0000639_abnormal_adrenal_gland0.45707096
120MP0002249_abnormal_larynx_morphology0.44253483

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.11125700
2Myokymia (HP:0002411)7.16407960
3Focal seizures (HP:0007359)6.09410574
4Visual hallucinations (HP:0002367)5.51930443
5Epileptic encephalopathy (HP:0200134)5.21199386
6Atonic seizures (HP:0010819)4.88270683
7Progressive cerebellar ataxia (HP:0002073)4.57032505
8Febrile seizures (HP:0002373)4.53979029
9Absence seizures (HP:0002121)4.35035202
10Generalized tonic-clonic seizures (HP:0002069)4.17780420
11Action tremor (HP:0002345)4.14917722
12Dialeptic seizures (HP:0011146)3.97898310
13Broad-based gait (HP:0002136)3.67463282
14Cerebral hypomyelination (HP:0006808)3.67444739
15Gaze-evoked nystagmus (HP:0000640)3.54845643
16Poor eye contact (HP:0000817)3.54679525
17Tetraplegia (HP:0002445)3.49996849
18Dysdiadochokinesis (HP:0002075)3.40775270
19Depression (HP:0000716)3.36595620
20Impaired vibration sensation in the lower limbs (HP:0002166)3.33005813
21Hyperventilation (HP:0002883)3.31099275
22Supranuclear gaze palsy (HP:0000605)3.30569299
23Truncal ataxia (HP:0002078)3.21875319
24Abnormal social behavior (HP:0012433)3.21562975
25Impaired social interactions (HP:0000735)3.21562975
26Dysmetria (HP:0001310)3.20889443
27Mutism (HP:0002300)3.20789444
28Urinary bladder sphincter dysfunction (HP:0002839)3.17576269
29Anxiety (HP:0000739)3.15602316
30Postural instability (HP:0002172)3.07144782
31Ankle clonus (HP:0011448)3.02375041
32Amblyopia (HP:0000646)2.92687881
33Abnormal eating behavior (HP:0100738)2.91137825
34Impaired smooth pursuit (HP:0007772)2.88528289
35Upper limb amyotrophy (HP:0009129)2.86702899
36Distal upper limb amyotrophy (HP:0007149)2.86702899
37Papilledema (HP:0001085)2.84688599
38Abnormality of the lower motor neuron (HP:0002366)2.83853979
39Ventricular fibrillation (HP:0001663)2.83843598
40Hand muscle atrophy (HP:0009130)2.82888294
41Akinesia (HP:0002304)2.80494863
42Genetic anticipation (HP:0003743)2.78861066
43Progressive inability to walk (HP:0002505)2.75175541
44Dysmetric saccades (HP:0000641)2.75037773
45Excessive salivation (HP:0003781)2.70994662
46Drooling (HP:0002307)2.70994662
47Urinary urgency (HP:0000012)2.64247940
48Hemiplegia (HP:0002301)2.61047076
49Torticollis (HP:0000473)2.59349665
50Cerebral inclusion bodies (HP:0100314)2.55696914
51Bradykinesia (HP:0002067)2.54572803
52Focal dystonia (HP:0004373)2.53828155
53Abnormality of binocular vision (HP:0011514)2.53609312
54Diplopia (HP:0000651)2.53609312
55Status epilepticus (HP:0002133)2.53559809
56Stereotypic behavior (HP:0000733)2.50815219
57Scanning speech (HP:0002168)2.50620500
58Hemiparesis (HP:0001269)2.50315603
59Abnormality of ocular smooth pursuit (HP:0000617)2.48712199
60Epileptiform EEG discharges (HP:0011182)2.46487951
61Spastic tetraparesis (HP:0001285)2.44569235
62Neurofibrillary tangles (HP:0002185)2.42623152
63Intention tremor (HP:0002080)2.40086943
64Annular pancreas (HP:0001734)2.39454869
65Pheochromocytoma (HP:0002666)2.39237170
66Spastic gait (HP:0002064)2.37042975
67CNS hypomyelination (HP:0003429)2.35768337
68EEG with generalized epileptiform discharges (HP:0011198)2.32173397
69Impaired vibratory sensation (HP:0002495)2.28367766
70Apathy (HP:0000741)2.25748809
71Inability to walk (HP:0002540)2.23218056
72Limb dystonia (HP:0002451)2.20628590
73Hypsarrhythmia (HP:0002521)2.20241328
74Absent speech (HP:0001344)2.20116480
75Bundle branch block (HP:0011710)2.19093952
76Craniofacial dystonia (HP:0012179)2.17890580
77Megalencephaly (HP:0001355)2.15568566
78Long palpebral fissure (HP:0000637)2.15339445
79Testicular atrophy (HP:0000029)2.12640435
80Incomplete penetrance (HP:0003829)2.08419519
81Generalized myoclonic seizures (HP:0002123)2.08025162
82Spinal canal stenosis (HP:0003416)2.06950407
83Delusions (HP:0000746)2.05635173
84Pointed chin (HP:0000307)2.04843568
85Abnormal EKG (HP:0003115)2.04756825
86Neuroendocrine neoplasm (HP:0100634)2.04515133
87Insidious onset (HP:0003587)2.03278281
88Termporal pattern (HP:0011008)2.03278281
89Fetal akinesia sequence (HP:0001989)2.01307423
90Diminished motivation (HP:0000745)2.01116099
91Peripheral hypomyelination (HP:0007182)2.00726995
92Lower limb muscle weakness (HP:0007340)1.99689714
93Choreoathetosis (HP:0001266)1.99269497
94J-shaped sella turcica (HP:0002680)1.97911099
95Slow saccadic eye movements (HP:0000514)1.96229804
96Gait ataxia (HP:0002066)1.95016585
97Syncope (HP:0001279)1.94754631
98Neuronal loss in central nervous system (HP:0002529)1.93270761
99Unsteady gait (HP:0002317)1.92480329
100Sudden death (HP:0001699)1.91981594
101Abnormal gallbladder physiology (HP:0012438)1.91597100
102Cholecystitis (HP:0001082)1.91597100
103Resting tremor (HP:0002322)1.91508830
104Polyphagia (HP:0002591)1.91025971
105Psychosis (HP:0000709)1.89720620
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89555382
107Sleep apnea (HP:0010535)1.88335482
108Rapidly progressive (HP:0003678)1.85605265
109Agitation (HP:0000713)1.85017825
110Obstructive sleep apnea (HP:0002870)1.84661635
111Hyperacusis (HP:0010780)1.81142759
112Rigidity (HP:0002063)1.80263439
113Morphological abnormality of the pyramidal tract (HP:0002062)1.79791325
114Lower limb asymmetry (HP:0100559)1.79702576
115Abnormality of saccadic eye movements (HP:0000570)1.79156471
116Abnormality of the corticospinal tract (HP:0002492)1.77705777
117Slow progression (HP:0003677)1.77388755
118Hypoventilation (HP:0002791)1.76405689
119Limb ataxia (HP:0002070)1.75618595
120Ankyloglossia (HP:0010296)1.75510887
121Abnormality of salivation (HP:0100755)1.75217234
122Prolonged QT interval (HP:0001657)1.75163977
123Amyotrophic lateral sclerosis (HP:0007354)1.74408994
124Lower limb amyotrophy (HP:0007210)1.73454080
125Clonus (HP:0002169)1.71310692
126Insomnia (HP:0100785)1.71303297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.60651538
2EPHA44.51399993
3MAP3K93.97224643
4MAP3K42.96487165
5MINK12.69799106
6DAPK22.68797555
7MAP2K72.44181927
8KSR22.27102093
9PAK62.27049689
10MARK12.25085735
11PRKD32.11359687
12RIPK42.03745344
13MAP2K42.00269479
14MAP3K121.95839876
15CAMKK11.80924789
16DAPK11.78389314
17NTRK11.78023847
18KSR11.76990080
19NTRK21.76452874
20CASK1.75733979
21PLK21.74091688
22ARAF1.69304222
23CDK191.62505653
24TRIB31.56452450
25CDK51.54743780
26GRK51.52586334
27PRPF4B1.52047483
28MAP3K131.39997844
29STK381.36105876
30PNCK1.31547552
31PRKCG1.27369176
32TESK11.25010835
33IRAK21.21965001
34FES1.20139527
35TNIK1.11329305
36CAMKK21.10029299
37MAP3K21.07849299
38UHMK11.07510445
39CAMK2A1.07174716
40MAPK131.06322699
41SIK21.05299306
42CAMK11.03876386
43PTK2B1.03459241
44PAK31.01008862
45CDK181.00755708
46TYRO30.98859512
47CDK150.98258499
48LATS20.96815781
49LIMK10.96505357
50BRSK10.95524859
51RAF10.94912108
52CDK140.93620643
53SGK2230.92756130
54SGK4940.92756130
55TAOK10.90866733
56CDK11A0.86041443
57STK110.85690104
58PINK10.84323281
59CAMK2B0.82265907
60OXSR10.81778402
61PRKCH0.80827183
62BMPR20.80478675
63RET0.77575102
64PDK10.75030970
65PHKG10.74461883
66PHKG20.74461883
67MAP3K110.70787855
68ICK0.69753050
69ALK0.68125462
70CCNB10.67759136
71SGK10.67584425
72SGK20.67390400
73PDPK10.66578153
74NEK10.62642250
75SGK30.62359477
76CAMK2D0.61441088
77SIK10.60460671
78DAPK30.60375035
79FER0.58924471
80MAP3K10.58165364
81CDC42BPA0.57174538
82DYRK1A0.57148084
83EEF2K0.56643703
84NME10.56103193
85LMTK20.55699118
86PRKD20.55686259
87SCYL20.55399691
88BRAF0.55081850
89MAP2K10.53167997
90WNK10.51757846
91NEK60.51671116
92TNK20.51446353
93CAMK2G0.50622124
94ERN10.50441426
95RPS6KA30.48342802
96PKN10.48124270
97CSNK1G20.47436045
98CAMK40.45863008
99MAP3K70.44811715
100RIPK10.44687131
101PRKCE0.44191386
102RPS6KA20.43964713
103MARK20.43086233
104SMG10.42774547
105PRKG20.42477158
106PRKCZ0.42351034
107TAOK20.41866052
108FYN0.41606491
109MAPK80.41356606
110MAPK100.40010935
111MAP3K60.39756630
112AKT30.39677146
113MAPK110.39176839
114AURKA0.39142375
115DMPK0.38200233
116BCR0.37657697
117MAP2K60.37392328
118MOS0.36327673
119FGR0.34107077
120ROCK20.33725878
121MAPK120.32765454
122AKT20.32610137
123PAK20.32310514
124PRKCA0.29511185
125PKN20.29236853

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80423679
2Synaptic vesicle cycle_Homo sapiens_hsa047213.44194355
3Long-term potentiation_Homo sapiens_hsa047202.84714500
4Circadian entrainment_Homo sapiens_hsa047132.75460884
5Olfactory transduction_Homo sapiens_hsa047402.71862181
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71251199
7GABAergic synapse_Homo sapiens_hsa047272.68119920
8Glutamatergic synapse_Homo sapiens_hsa047242.62307216
9Amphetamine addiction_Homo sapiens_hsa050312.58592668
10Morphine addiction_Homo sapiens_hsa050322.46809829
11Salivary secretion_Homo sapiens_hsa049702.24541206
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24451689
13Dopaminergic synapse_Homo sapiens_hsa047282.15782336
14Insulin secretion_Homo sapiens_hsa049112.05740387
15Gastric acid secretion_Homo sapiens_hsa049711.93259506
16Cholinergic synapse_Homo sapiens_hsa047251.88565484
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87438169
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78770818
19Taste transduction_Homo sapiens_hsa047421.76796257
20Long-term depression_Homo sapiens_hsa047301.75999326
21Oxytocin signaling pathway_Homo sapiens_hsa049211.72743361
22Renin secretion_Homo sapiens_hsa049241.65827491
23Calcium signaling pathway_Homo sapiens_hsa040201.64403419
24Serotonergic synapse_Homo sapiens_hsa047261.60198251
25Cocaine addiction_Homo sapiens_hsa050301.58828697
26Collecting duct acid secretion_Homo sapiens_hsa049661.55931381
27GnRH signaling pathway_Homo sapiens_hsa049121.48259742
28Cardiac muscle contraction_Homo sapiens_hsa042601.40015390
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37470794
30Gap junction_Homo sapiens_hsa045401.37470708
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33455350
32cAMP signaling pathway_Homo sapiens_hsa040241.27635672
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26414351
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23219161
35Type II diabetes mellitus_Homo sapiens_hsa049301.14169473
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14058080
37Glioma_Homo sapiens_hsa052141.12499331
38Estrogen signaling pathway_Homo sapiens_hsa049151.11912541
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11137215
40Vitamin B6 metabolism_Homo sapiens_hsa007501.08062637
41Melanogenesis_Homo sapiens_hsa049161.04055302
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00722148
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.97065666
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96637570
45Vibrio cholerae infection_Homo sapiens_hsa051100.96524246
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96466423
47ErbB signaling pathway_Homo sapiens_hsa040120.95598063
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95171092
49Dilated cardiomyopathy_Homo sapiens_hsa054140.94897335
50Axon guidance_Homo sapiens_hsa043600.94486660
51Nitrogen metabolism_Homo sapiens_hsa009100.93902704
52Oocyte meiosis_Homo sapiens_hsa041140.91987765
53Phototransduction_Homo sapiens_hsa047440.89831969
54Pancreatic secretion_Homo sapiens_hsa049720.83821994
55Thyroid hormone synthesis_Homo sapiens_hsa049180.82050127
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.79011655
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73798328
58Dorso-ventral axis formation_Homo sapiens_hsa043200.73594723
59Mineral absorption_Homo sapiens_hsa049780.72654491
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71107162
61MAPK signaling pathway_Homo sapiens_hsa040100.68351312
62Alzheimers disease_Homo sapiens_hsa050100.65539105
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64910905
64VEGF signaling pathway_Homo sapiens_hsa043700.62842562
65Glucagon signaling pathway_Homo sapiens_hsa049220.62437146
66Choline metabolism in cancer_Homo sapiens_hsa052310.62305172
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61757623
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.60415690
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58693219
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57317282
71Rap1 signaling pathway_Homo sapiens_hsa040150.53672957
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53552411
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53342291
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52441688
75Oxidative phosphorylation_Homo sapiens_hsa001900.51888041
76Ras signaling pathway_Homo sapiens_hsa040140.49725494
77Inositol phosphate metabolism_Homo sapiens_hsa005620.48272157
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47480672
79Bile secretion_Homo sapiens_hsa049760.46746361
80Circadian rhythm_Homo sapiens_hsa047100.46518456
81Type I diabetes mellitus_Homo sapiens_hsa049400.45880077
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45665159
83Alcoholism_Homo sapiens_hsa050340.44566495
84mTOR signaling pathway_Homo sapiens_hsa041500.43641832
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.43328273
86Arginine and proline metabolism_Homo sapiens_hsa003300.42789022
87Parkinsons disease_Homo sapiens_hsa050120.42691165
88Non-small cell lung cancer_Homo sapiens_hsa052230.42347749
89Prion diseases_Homo sapiens_hsa050200.41747902
90AMPK signaling pathway_Homo sapiens_hsa041520.41447782
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40719208
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40564068
93Endocytosis_Homo sapiens_hsa041440.40386685
94Wnt signaling pathway_Homo sapiens_hsa043100.38029056
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37428170
96African trypanosomiasis_Homo sapiens_hsa051430.36209910
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36186669
98Endometrial cancer_Homo sapiens_hsa052130.35935206
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34530172
100Insulin signaling pathway_Homo sapiens_hsa049100.34321129
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33742735
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33711775
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32509554
104Hippo signaling pathway_Homo sapiens_hsa043900.32351451
105Arginine biosynthesis_Homo sapiens_hsa002200.32089837
106Renal cell carcinoma_Homo sapiens_hsa052110.30977240
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29631344
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28991426
109Ovarian steroidogenesis_Homo sapiens_hsa049130.26008048
110Huntingtons disease_Homo sapiens_hsa050160.23553867
111Chemokine signaling pathway_Homo sapiens_hsa040620.22612477
112Proteoglycans in cancer_Homo sapiens_hsa052050.22138030
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.20878220
114HIF-1 signaling pathway_Homo sapiens_hsa040660.20571011
115Folate biosynthesis_Homo sapiens_hsa007900.19300863

Most similar genes based on co-expression Upload to Enrichr

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