ANKRD35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.90084198
2cilium movement (GO:0003341)8.34252965
3multicellular organismal water homeostasis (GO:0050891)8.06245984
4keratinocyte differentiation (GO:0030216)7.75462160
5motile cilium assembly (GO:0044458)7.57616187
6epithelial cilium movement (GO:0003351)7.54846946
7hemidesmosome assembly (GO:0031581)7.43472340
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.27688893
9water homeostasis (GO:0030104)6.62357777
10long-chain fatty acid biosynthetic process (GO:0042759)6.60176105
11peptide cross-linking (GO:0018149)6.24943262
12intermediate filament organization (GO:0045109)5.98256948
13epidermal cell differentiation (GO:0009913)5.86341149
14sphingoid metabolic process (GO:0046519)5.74215866
15hair cycle (GO:0042633)5.72923928
16molting cycle (GO:0042303)5.72923928
17keratinocyte proliferation (GO:0043616)5.72210934
18axoneme assembly (GO:0035082)5.66705104
19bundle of His cell to Purkinje myocyte communication (GO:0086069)5.66332942
20left/right pattern formation (GO:0060972)5.46243484
21epidermis development (GO:0008544)5.20328678
22sphingosine metabolic process (GO:0006670)5.20203457
23regulation of cilium movement (GO:0003352)4.76508414
24primary alcohol catabolic process (GO:0034310)4.72921480
25diol metabolic process (GO:0034311)4.67261222
26regulation of ruffle assembly (GO:1900027)4.67127651
27keratinocyte development (GO:0003334)4.43672320
28ectoderm development (GO:0007398)4.37157491
29sperm motility (GO:0030317)4.29846152
30linoleic acid metabolic process (GO:0043651)4.22543435
31negative regulation of inclusion body assembly (GO:0090084)4.20582624
32intestinal epithelial cell development (GO:0060576)4.16253180
33interferon-gamma secretion (GO:0072643)4.14467426
34glomerular epithelial cell development (GO:0072310)4.10486622
35microtubule bundle formation (GO:0001578)4.07154880
36ethanol metabolic process (GO:0006067)4.05316582
37one-carbon compound transport (GO:0019755)4.00646026
38sperm capacitation (GO:0048240)3.79779016
39left/right axis specification (GO:0070986)3.78015257
40detection of bacterium (GO:0016045)3.75846108
41glucosamine-containing compound catabolic process (GO:1901072)3.71915664
42intermediate filament cytoskeleton organization (GO:0045104)3.70492500
43negative regulation of stress fiber assembly (GO:0051497)3.69851533
44positive regulation of vesicle fusion (GO:0031340)3.69725058
45regulation of inclusion body assembly (GO:0090083)3.61964388
46lipoxygenase pathway (GO:0019372)3.61455613
47intermediate filament-based process (GO:0045103)3.57382792
48fusion of sperm to egg plasma membrane (GO:0007342)3.52894010
49chemosensory behavior (GO:0007635)3.43377106
50ventricular system development (GO:0021591)3.42531935
51regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.40923409
52skin morphogenesis (GO:0043589)3.37508992
53regulation of microtubule-based movement (GO:0060632)3.34566215
54centriole assembly (GO:0098534)3.33150256
55microtubule polymerization or depolymerization (GO:0031109)3.30997415
56phosphatidylinositol acyl-chain remodeling (GO:0036149)3.27993789
57establishment of tissue polarity (GO:0007164)3.23929638
58establishment of planar polarity (GO:0001736)3.23929638
59planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23359005
60fatty acid elongation (GO:0030497)3.23117306
61eyelid development in camera-type eye (GO:0061029)3.22846091
62phospholipid scrambling (GO:0017121)3.21943848
63skin development (GO:0043588)3.21157923
64regulation of transforming growth factor beta1 production (GO:0032908)3.20938383
65retinol metabolic process (GO:0042572)3.11855999
66ethanol oxidation (GO:0006069)3.09779806
67female mating behavior (GO:0060180)3.07162400
68regulation of clathrin-mediated endocytosis (GO:2000369)3.00900012
69cilium organization (GO:0044782)3.00685004
70primary alcohol metabolic process (GO:0034308)3.00659233
71axon ensheathment in central nervous system (GO:0032291)3.00141082
72central nervous system myelination (GO:0022010)3.00141082
73negative regulation of actin filament bundle assembly (GO:0032232)2.98645453
74regulation of phospholipase A2 activity (GO:0032429)2.97537809
75cilium assembly (GO:0042384)2.96282072
76intraciliary transport (GO:0042073)2.96070009
77regulation of female receptivity (GO:0045924)2.95515938
78regulation of vesicle fusion (GO:0031338)2.93153702
79regulation of glomerular filtration (GO:0003093)2.92967499
80regulation of cell proliferation involved in kidney development (GO:1901722)2.90911384
81detection of other organism (GO:0098543)2.88933151
82cell communication involved in cardiac conduction (GO:0086065)2.88814180
83cell wall macromolecule catabolic process (GO:0016998)2.88733672
84metanephric mesenchyme development (GO:0072075)2.88316284
85vocalization behavior (GO:0071625)2.85518439
86centriole replication (GO:0007099)2.85397323
87regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84991878
88epithelial cell-cell adhesion (GO:0090136)2.84796946
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.82734139
90ephrin receptor signaling pathway (GO:0048013)2.82514272
91lung epithelium development (GO:0060428)2.82131805
92regulation of heart rate by cardiac conduction (GO:0086091)2.81252807
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.80710513
94ventricular cardiac muscle cell action potential (GO:0086005)2.79184111
95regulation of natural killer cell differentiation (GO:0032823)2.77285627
96prostaglandin biosynthetic process (GO:0001516)2.74284074
97prostanoid biosynthetic process (GO:0046457)2.74284074
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.73032698
99positive regulation of glomerulus development (GO:0090193)2.72272695
100acrosome reaction (GO:0007340)2.71629379
101protein polyglutamylation (GO:0018095)2.71326213
102negative regulation of Ras GTPase activity (GO:0034261)2.70355802
103regulation of short-term neuronal synaptic plasticity (GO:0048172)2.69831071
104phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69010508
105cell-substrate junction assembly (GO:0007044)2.68065870
106positive regulation of mitochondrial membrane permeability (GO:0035794)2.67734302
107cardiac conduction (GO:0061337)2.67490398
108chemical homeostasis within a tissue (GO:0048875)2.65786700
109skeletal muscle contraction (GO:0003009)2.65373424
110dendritic spine organization (GO:0097061)2.64910835
111regulation of axon regeneration (GO:0048679)2.64867156
112regulation of neuron projection regeneration (GO:0070570)2.64867156
113mitochondrion degradation (GO:0000422)2.64411922
114apical protein localization (GO:0045176)2.63426329
115cellular component assembly involved in morphogenesis (GO:0010927)2.62829625
116plasma membrane fusion (GO:0045026)2.62070233
117regulation of hypersensitivity (GO:0002883)2.61940649
118cell wall macromolecule metabolic process (GO:0044036)2.59542363
119cytoplasmic microtubule organization (GO:0031122)2.59205981
120negative regulation of keratinocyte proliferation (GO:0010839)2.59147997
121microtubule-based movement (GO:0007018)2.58886373
122cerebellar Purkinje cell differentiation (GO:0021702)2.58714335
123plasma membrane repair (GO:0001778)2.57737262
124regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.57702898
125protein localization to endosome (GO:0036010)2.55115489
126lateral sprouting from an epithelium (GO:0060601)2.54701253
127lung-associated mesenchyme development (GO:0060484)2.54343468
128otic vesicle formation (GO:0030916)2.53838398
129sarcoplasmic reticulum calcium ion transport (GO:0070296)2.52304754
130interleukin-1-mediated signaling pathway (GO:0070498)2.52064849
131kidney mesenchyme development (GO:0072074)2.50604280
132negative regulation by host of viral transcription (GO:0043922)2.50080575
133negative regulation of interferon-gamma production (GO:0032689)2.48563618
134negative regulation of cell fate commitment (GO:0010454)2.47815175
135phosphatidylserine acyl-chain remodeling (GO:0036150)2.47237736
136non-canonical Wnt signaling pathway (GO:0035567)2.44813006
137G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.44755107
138peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44274418
139adhesion of symbiont to host cell (GO:0044650)2.43972613
140virion attachment to host cell (GO:0019062)2.43972613
141embryonic camera-type eye development (GO:0031076)2.43691152
142cardiac right ventricle morphogenesis (GO:0003215)2.43111125
143arachidonic acid secretion (GO:0050482)2.42966969
144icosanoid secretion (GO:0032309)2.42966969
145neuronal ion channel clustering (GO:0045161)2.42876115
146sphingolipid biosynthetic process (GO:0030148)2.41714001
147epithelium development (GO:0060429)2.40596151
148long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.40244098
149phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.39812136
150protein heterotrimerization (GO:0070208)2.39728054
151phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.39018749
152negative regulation of cell fate specification (GO:0009996)2.38156316
153Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.35586239
154synaptic vesicle maturation (GO:0016188)2.34741135
155protein localization to cilium (GO:0061512)2.34266394
156neuromuscular process controlling posture (GO:0050884)2.34159200
157regulation of Cdc42 GTPase activity (GO:0043088)2.32814213
158regulation of posttranscriptional gene silencing (GO:0060147)2.32498793
159regulation of gene silencing by miRNA (GO:0060964)2.32498793
160regulation of gene silencing by RNA (GO:0060966)2.32498793
161glutamate secretion (GO:0014047)2.31349880
162carnitine metabolic process (GO:0009437)2.29655752
163regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.27463466
164glomerular visceral epithelial cell development (GO:0072015)2.26933227
165myoblast migration (GO:0051451)2.23320583
166pyrimidine-containing compound transmembrane transport (GO:0072531)2.22810749
167hydrogen peroxide catabolic process (GO:0042744)2.21187859
168cell projection assembly (GO:0030031)2.19130005
169desmosome organization (GO:0002934)14.1047539
170establishment of skin barrier (GO:0061436)12.7887383
171keratinization (GO:0031424)11.9341008
172regulation of water loss via skin (GO:0033561)11.6888623
173axonemal dynein complex assembly (GO:0070286)11.4440240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.15561698
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.71993034
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.46084571
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.34544130
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.15990187
6ZNF263_19887448_ChIP-Seq_K562_Human2.14143379
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.11093779
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07417219
9TP63_17297297_ChIP-ChIP_HaCaT_Human12.8524188
10EZH2_22144423_ChIP-Seq_EOC_Human1.94400466
11RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90453832
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78233231
13* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.74742651
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72773420
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.71667829
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.70911795
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60302663
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60302663
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60302663
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.59230816
21SMC4_20622854_ChIP-Seq_HELA_Human1.55718949
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54676504
23* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.54644546
24* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.47516681
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46831331
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45229294
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45229294
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44719166
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42339475
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.41321030
31RXR_22108803_ChIP-Seq_LS180_Human1.39431187
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38630671
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37790275
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34411661
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34188081
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.33623689
37KLF5_25053715_ChIP-Seq_YYC3_Human1.33438306
38* RUNX1_27514584_Chip-Seq_MCF-7_Human1.33184815
39AR_21572438_ChIP-Seq_LNCaP_Human1.30637084
40KDM2B_26808549_Chip-Seq_K562_Human1.29724282
41CTCF_20526341_ChIP-Seq_ESCs_Human1.27785326
42* TP63_22573176_ChIP-Seq_HFKS_Human1.27672964
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.26500576
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26406934
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.22051196
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20947223
47P68_20966046_ChIP-Seq_HELA_Human1.20542821
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.19933144
49RACK7_27058665_Chip-Seq_MCF-7_Human1.19645185
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19227445
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18835533
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18661138
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18661138
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18282812
55* TP63_23658742_ChIP-Seq_EP156T_Human1.18280756
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15780675
57CTCF_27219007_Chip-Seq_Bcells_Human1.15625597
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15109596
59* GATA6_21074721_ChIP-Seq_CACO-2_Human1.13772119
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13429524
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12088480
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11989257
63AHR_22903824_ChIP-Seq_MCF-7_Human1.11882192
64* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11862490
65MYC_19829295_ChIP-Seq_ESCs_Human1.11003863
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10534892
67SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10382903
68RBPJ_21746931_ChIP-Seq_IB4_Human1.09616988
69* SA1_27219007_Chip-Seq_Bcells_Human1.09023105
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.09001901
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08430923
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08323819
73ATF3_27146783_Chip-Seq_COLON_Human1.08244221
74* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08180154
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06551628
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06352724
77* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06198264
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06191686
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06075508
80TAF2_19829295_ChIP-Seq_ESCs_Human1.05721183
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05280296
82PHF8_20622853_ChIP-Seq_HELA_Human1.05209237
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05061621
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03745110
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03216683
86* ETV1_20927104_ChIP-Seq_GIST48_Human1.02668982
87* HNFA_21074721_ChIP-Seq_CACO-2_Human1.01272074
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.00984108
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.99947399
90TP53_18474530_ChIP-ChIP_U2OS_Human0.99560447
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99015547
92ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98876014
93* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98672955
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98399472
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97134274
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96644171
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.96424934
98DROSHA_22980978_ChIP-Seq_HELA_Human0.95922704
99SOX2_20726797_ChIP-Seq_SW620_Human0.95211965
100MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95130747
101P53_21459846_ChIP-Seq_SAOS-2_Human0.94893935
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94455674
103E2F1_20622854_ChIP-Seq_HELA_Human0.94042036
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92626026
105EED_16625203_ChIP-ChIP_MESCs_Mouse0.92077825
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92054255
107P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91593407
108* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.90851187
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90716746
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90716746
111TBL1_22424771_ChIP-Seq_293T_Human0.90515127
112TP53_16413492_ChIP-PET_HCT116_Human0.89668811
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.89618778
114SOX2_21211035_ChIP-Seq_LN229_Human0.89615724
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89543369
116REST_21632747_ChIP-Seq_MESCs_Mouse0.89509446
117PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89376852
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89091472
119ERG_20517297_ChIP-Seq_VCAP_Human0.88488779
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88229439
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.88083342
122STAT1_20625510_ChIP-Seq_HELA_Human0.87919795
123* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87695309
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87205946
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.87205244
126* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.86841678
127FOXH1_21741376_ChIP-Seq_ESCs_Human0.86152390
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85789731
129* CJUN_26792858_Chip-Seq_BT549_Human0.85690395
130SMAD4_21799915_ChIP-Seq_A2780_Human0.85041191
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84781594
132BCL6_27268052_Chip-Seq_Bcells_Human0.84762856
133BCOR_27268052_Chip-Seq_Bcells_Human0.84581191
134NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84341064
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.84033849
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83919329
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83897331
138BCAT_22108803_ChIP-Seq_LS180_Human0.83633018
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.83327147
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83320023
141LXR_22292898_ChIP-Seq_THP-1_Human0.83315650
142TCF4_22108803_ChIP-Seq_LS180_Human0.83262456
143BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82655745
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81273610
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.80519617
146* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80429704
147VDR_22108803_ChIP-Seq_LS180_Human0.80226638
148UBF1/2_26484160_Chip-Seq_HMECs_Human0.79625183
149* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78703621
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.76629735
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76248200
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75992812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.83664014
2MP0002254_reproductive_system_inflammat6.19980478
3MP0005275_abnormal_skin_tensile5.44729124
4MP0003941_abnormal_skin_development5.11450818
5MP0010234_abnormal_vibrissa_follicle5.01690620
6MP0005501_abnormal_skin_physiology4.73768157
7MP0009780_abnormal_chondrocyte_physiolo3.58673029
8MP0005503_abnormal_tendon_morphology3.40737902
9MP0000579_abnormal_nail_morphology3.40551853
10MP0001216_abnormal_epidermal_layer3.14726605
11MP0002060_abnormal_skin_morphology3.12315520
12MP0010771_integument_phenotype2.96028430
13MP0001346_abnormal_lacrimal_gland2.87494463
14MP0005377_hearing/vestibular/ear_phenot2.86856228
15MP0003878_abnormal_ear_physiology2.86856228
16MP0003453_abnormal_keratinocyte_physiol2.70995147
17MP0004381_abnormal_hair_follicle2.64684620
18MP0000383_abnormal_hair_follicle2.53600054
19MP0010678_abnormal_skin_adnexa2.46634596
20MP0000647_abnormal_sebaceous_gland2.42098052
21MP0002653_abnormal_ependyma_morphology2.39376135
22MP0000467_abnormal_esophagus_morphology2.22277632
23MP0003705_abnormal_hypodermis_morpholog2.05469727
24MP0002098_abnormal_vibrissa_morphology2.03401512
25MP0004947_skin_inflammation1.99908641
26MP0000377_abnormal_hair_follicle1.94901147
27MP0000751_myopathy1.91910824
28MP0003646_muscle_fatigue1.89154623
29MP0008789_abnormal_olfactory_epithelium1.86687339
30MP0002009_preneoplasia1.86094634
31MP0000749_muscle_degeneration1.84148122
32MP0009384_cardiac_valve_regurgitation1.82589081
33MP0004185_abnormal_adipocyte_glucose1.80101598
34MP0005451_abnormal_body_composition1.78422092
35MP0000566_synostosis1.76390371
36MP0003011_delayed_dark_adaptation1.72665804
37MP0000762_abnormal_tongue_morphology1.69708921
38MP0000427_abnormal_hair_cycle1.69455642
39MP0003566_abnormal_cell_adhesion1.69246820
40MP0005423_abnormal_somatic_nervous1.68379451
41MP0001191_abnormal_skin_condition1.64692688
42MP0009931_abnormal_skin_appearance1.45662300
43MP0001348_abnormal_lacrimal_gland1.43366541
44MP0005410_abnormal_fertilization1.36969151
45MP0002877_abnormal_melanocyte_morpholog1.35278406
46MP0002132_abnormal_respiratory_system1.34243970
47MP0008004_abnormal_stomach_pH1.31955718
48MP0003283_abnormal_digestive_organ1.30450998
49MP0004043_abnormal_pH_regulation1.30220491
50MP0002108_abnormal_muscle_morphology1.26547241
51MP0004859_abnormal_synaptic_plasticity1.23770490
52MP0002282_abnormal_trachea_morphology1.18604402
53MP0008438_abnormal_cutaneous_collagen1.18403426
54MP0010352_gastrointestinal_tract_polyps1.16533368
55MP0005076_abnormal_cell_differentiation1.13070662
56MP0001958_emphysema1.11766966
57MP0003279_aneurysm1.10356336
58MP0001542_abnormal_bone_strength1.09904938
59MP0001485_abnormal_pinna_reflex1.09095338
60MP0000367_abnormal_coat/_hair1.06046702
61MP0008875_abnormal_xenobiotic_pharmacok1.05834179
62MP0004858_abnormal_nervous_system1.04615356
63MP0005670_abnormal_white_adipose1.04269051
64MP0001243_abnormal_dermal_layer1.03633244
65MP0002734_abnormal_mechanical_nocicepti1.00924364
66MP0001849_ear_inflammation0.97307372
67MP0009379_abnormal_foot_pigmentation0.95363120
68MP0003136_yellow_coat_color0.93452528
69MP0002277_abnormal_respiratory_mucosa0.92237972
70MP0001851_eye_inflammation0.91791111
71MP0009046_muscle_twitch0.89398023
72MP0001486_abnormal_startle_reflex0.86252613
73MP0000516_abnormal_urinary_system0.82863173
74MP0005367_renal/urinary_system_phenotyp0.82863173
75MP0006276_abnormal_autonomic_nervous0.82329172
76MP0001340_abnormal_eyelid_morphology0.81498627
77MP0001188_hyperpigmentation0.79564800
78MP0003880_abnormal_central_pattern0.78940301
79MP0002234_abnormal_pharynx_morphology0.78801970
80MP0005620_abnormal_muscle_contractility0.78485506
81MP0002896_abnormal_bone_mineralization0.76551951
82MP0004270_analgesia0.75740099
83MP0000049_abnormal_middle_ear0.75115514
84MP0008961_abnormal_basal_metabolism0.74506506
85MP0004264_abnormal_extraembryonic_tissu0.73289930
86MP0000627_abnormal_mammary_gland0.72935270
87MP0002295_abnormal_pulmonary_circulatio0.72709640
88MP0004019_abnormal_vitamin_homeostasis0.70971591
89MP0002272_abnormal_nervous_system0.70106685
90MP0000470_abnormal_stomach_morphology0.69856239
91MP0002090_abnormal_vision0.65835219
92MP0001784_abnormal_fluid_regulation0.64107931
93MP0005253_abnormal_eye_physiology0.63832753
94MP0003755_abnormal_palate_morphology0.61932596
95MP0004133_heterotaxia0.61908728
96MP0005623_abnormal_meninges_morphology0.61427570
97MP0001984_abnormal_olfaction0.60906238
98MP0003635_abnormal_synaptic_transmissio0.60597177
99MP0005551_abnormal_eye_electrophysiolog0.58142044
100MP0002064_seizures0.57753242
101MP0005310_abnormal_salivary_gland0.57656879
102MP0010030_abnormal_orbit_morphology0.57397668
103MP0002133_abnormal_respiratory_system0.56746923
104MP0005388_respiratory_system_phenotype0.56746923
105MP0002972_abnormal_cardiac_muscle0.56498552
106MP0004087_abnormal_muscle_fiber0.56204120
107MP0001905_abnormal_dopamine_level0.55692578
108MP0000613_abnormal_salivary_gland0.54633954
109MP0000026_abnormal_inner_ear0.53898503
110MP0000428_abnormal_craniofacial_morphol0.52916167
111MP0002249_abnormal_larynx_morphology0.52615581
112MP0004145_abnormal_muscle_electrophysio0.51861575
113MP0005165_increased_susceptibility_to0.51065530
114MP0002177_abnormal_outer_ear0.50862570
115MP0005595_abnormal_vascular_smooth0.50096133
116MP0003698_abnormal_male_reproductive0.50075670
117MP0001299_abnormal_eye_distance/0.49522378
118MP0005023_abnormal_wound_healing0.49068314
119MP0003315_abnormal_perineum_morphology0.48378801
120MP0008569_lethality_at_weaning0.47462805
121MP0003329_amyloid_beta_deposits0.46821529
122MP0000537_abnormal_urethra_morphology0.46676887
123MP0002733_abnormal_thermal_nociception0.45803938
124MP0002063_abnormal_learning/memory/cond0.45487384
125MP0002111_abnormal_tail_morphology0.42168604
126MP0002006_tumorigenesis0.41241589
127MP0001501_abnormal_sleep_pattern0.40723695
128MP0002233_abnormal_nose_morphology0.40594799
129MP0009053_abnormal_anal_canal0.37386629
130MP0001873_stomach_inflammation0.36826396
131MP0004885_abnormal_endolymph0.36582142
132MP0009745_abnormal_behavioral_response0.36332056
133MP0003385_abnormal_body_wall0.36325948
134MP0005508_abnormal_skeleton_morphology0.36261990
135MP0002163_abnormal_gland_morphology0.36141903
136MP0000538_abnormal_urinary_bladder0.34473845
137MP0003119_abnormal_digestive_system0.34290162
138MP0005666_abnormal_adipose_tissue0.33987460
139MP0003787_abnormal_imprinting0.33458374
140MP0003936_abnormal_reproductive_system0.33403745
141MP0002184_abnormal_innervation0.32990000
142MP0000432_abnormal_head_morphology0.31365403
143MP0003879_abnormal_hair_cell0.31212800
144MP0005499_abnormal_olfactory_system0.30151525
145MP0005394_taste/olfaction_phenotype0.30151525
146MP0003191_abnormal_cellular_cholesterol0.29792506
147MP0004782_abnormal_surfactant_physiolog0.26695562
148MP0005645_abnormal_hypothalamus_physiol0.26179458
149MP0003638_abnormal_response/metabolism_0.26129892

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.72000380
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.00651356
3Absent/shortened dynein arms (HP:0200106)8.00651356
4Abnormal respiratory epithelium morphology (HP:0012253)7.89061087
5Abnormal respiratory motile cilium morphology (HP:0005938)7.89061087
6Abnormal respiratory motile cilium physiology (HP:0012261)7.70517019
7Abnormal ciliary motility (HP:0012262)7.63619952
8Rhinitis (HP:0012384)7.09749409
9Hypotrichosis (HP:0001006)6.71918863
10Plantar hyperkeratosis (HP:0007556)6.13949400
11Congenital ichthyosiform erythroderma (HP:0007431)6.10569485
12Increased IgE level (HP:0003212)6.06271374
13Chronic bronchitis (HP:0004469)5.82624413
14Palmoplantar hyperkeratosis (HP:0000972)5.78673849
15Woolly hair (HP:0002224)5.61281858
16Right ventricular cardiomyopathy (HP:0011663)5.59292949
17Abnormality of nail color (HP:0100643)5.55242069
18Lip pit (HP:0100267)5.52176199
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.46401606
20Palmar hyperkeratosis (HP:0010765)5.46136182
21Nasal polyposis (HP:0100582)5.27260012
22Erythema (HP:0010783)5.05247429
23Onycholysis (HP:0001806)4.97383029
24Bronchiectasis (HP:0002110)4.72723756
25Abnormality of the nasal mucosa (HP:0000433)4.69041069
26Fragile nails (HP:0001808)4.45921354
27Erythroderma (HP:0001019)4.24932532
28Milia (HP:0001056)4.24031960
29Abnormal blistering of the skin (HP:0008066)3.88692779
30Hypohidrosis (HP:0000966)3.80822220
31Ectropion (HP:0000656)3.72277400
32Hyporeflexia of lower limbs (HP:0002600)3.71233341
33Pili torti (HP:0003777)3.70111282
34Conjunctival hamartoma (HP:0100780)3.64498508
35Curly hair (HP:0002212)3.61252137
36Corneal erosion (HP:0200020)3.60246951
37Nail dystrophy (HP:0008404)3.59634443
38Parakeratosis (HP:0001036)3.50029311
39Distal lower limb muscle weakness (HP:0009053)3.43477935
40Thick nail (HP:0001805)3.33150083
41Abnormality of the salivary glands (HP:0010286)3.10303046
42Infertility (HP:0000789)3.10286460
43Gangrene (HP:0100758)3.09053934
44Natal tooth (HP:0000695)3.08631434
45Palmoplantar keratoderma (HP:0000982)3.07843290
46Sparse scalp hair (HP:0002209)3.03033713
47Bronchitis (HP:0012387)2.89677618
48Concave nail (HP:0001598)2.89558442
49Muscle fiber splitting (HP:0003555)2.83951278
50Ventricular tachycardia (HP:0004756)2.83914693
51Atrophic scars (HP:0001075)2.82232517
52Ventricular fibrillation (HP:0001663)2.81750895
53Advanced eruption of teeth (HP:0006288)2.80205348
54Abnormality of secondary sexual hair (HP:0009888)2.77163195
55Abnormality of the axillary hair (HP:0100134)2.77163195
56Male infertility (HP:0003251)2.76357182
57Areflexia of lower limbs (HP:0002522)2.73324892
58Sparse eyelashes (HP:0000653)2.73226189
59Abnormality of the gastric mucosa (HP:0004295)2.67727182
60Alopecia of scalp (HP:0002293)2.64923426
61Atelectasis (HP:0100750)2.62342995
62Hamartoma of the eye (HP:0010568)2.61925110
63Acanthosis nigricans (HP:0000956)2.59683908
64Ridged nail (HP:0001807)2.57887886
65Myokymia (HP:0002411)2.52350612
66Abnormality of molar (HP:0011077)2.38636789
67Abnormality of molar morphology (HP:0011070)2.38636789
68Chronic sinusitis (HP:0011109)2.36949333
69Abnormality of permanent molar morphology (HP:0011071)2.36733012
70Abnormality of the dental root (HP:0006486)2.36733012
71Taurodontia (HP:0000679)2.36733012
72Pruritus (HP:0000989)2.36349897
73Hyperkalemia (HP:0002153)2.34120055
74Muscle fiber inclusion bodies (HP:0100299)2.33876308
75Ulnar claw (HP:0001178)2.33337314
76Popliteal pterygium (HP:0009756)2.32583185
77Recurrent otitis media (HP:0000403)2.32255802
78Oral leukoplakia (HP:0002745)2.30566049
79Chronic hepatic failure (HP:0100626)2.28978188
80Hypoplastic labia majora (HP:0000059)2.28581760
81Asplenia (HP:0001746)2.27785145
82Abnormality of the dental pulp (HP:0006479)2.27196607
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.26010259
84Nemaline bodies (HP:0003798)2.23597199
85Blepharitis (HP:0000498)2.20514932
86Aplasia/Hypoplasia of the spleen (HP:0010451)2.20057347
87Recurrent sinusitis (HP:0011108)2.18783285
88Aplasia involving bones of the upper limbs (HP:0009823)2.18676674
89Aplasia of the phalanges of the hand (HP:0009802)2.18676674
90Aplasia involving bones of the extremities (HP:0009825)2.18676674
91Nonprogressive disorder (HP:0003680)2.18417007
92Abnormal hair laboratory examination (HP:0003328)2.18159977
93Increased connective tissue (HP:0009025)2.17506267
94True hermaphroditism (HP:0010459)2.17240928
95Abnormality of the labia majora (HP:0012881)2.15003742
96Distal lower limb amyotrophy (HP:0008944)2.11111036
97Achilles tendon contracture (HP:0001771)2.09657257
98Round ear (HP:0100830)2.08966767
99Occipital encephalocele (HP:0002085)2.07622384
100Lack of skin elasticity (HP:0100679)2.07242635
101Fatigable weakness (HP:0003473)2.03977724
102Abnormality of the neuromuscular junction (HP:0003398)2.03977724
103Neonatal short-limb short stature (HP:0008921)2.03211851
104Hypodontia (HP:0000668)2.00520676
105Hypoplasia of dental enamel (HP:0006297)2.00439948
106Pancreatic fibrosis (HP:0100732)1.99418629
107Dry skin (HP:0000958)1.99390418
108Aplasia cutis congenita (HP:0001057)1.98370448
109Fragile skin (HP:0001030)1.96395775
110Oligodontia (HP:0000677)1.94966692
111Hypercortisolism (HP:0001578)1.94699884
112Hyperactive renin-angiotensin system (HP:0000841)1.91669161
113Esophageal atresia (HP:0002032)1.91365719
114Bell-shaped thorax (HP:0001591)1.88527838
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87792737
116Ankyloglossia (HP:0010296)1.86976294
117Focal motor seizures (HP:0011153)1.83091240
118Severe Myopia (HP:0011003)1.81572304
119Upper limb muscle weakness (HP:0003484)1.81083919
120Abnormality of the Achilles tendon (HP:0005109)1.76800221
121Absent hair (HP:0002298)1.76719190
122Exercise-induced myalgia (HP:0003738)1.76371272
123Skin pits (HP:0100276)1.75062460
124Nephronophthisis (HP:0000090)1.74295399
125Obstructive sleep apnea (HP:0002870)1.74241946
126Pterygium (HP:0001059)1.73984607
127Anonychia (HP:0001798)1.73842544
128EMG: neuropathic changes (HP:0003445)1.72643900
129Mildly elevated creatine phosphokinase (HP:0008180)1.71863476
130Follicular hyperkeratosis (HP:0007502)1.71425714
131Broad metatarsal (HP:0001783)1.71238151
132Recurrent corneal erosions (HP:0000495)1.71226462
133Premature ovarian failure (HP:0008209)1.68943513
134Bronchomalacia (HP:0002780)1.68821308
135Conical tooth (HP:0000698)1.67074730
136Molar tooth sign on MRI (HP:0002419)1.66072214
137Abnormality of midbrain morphology (HP:0002418)1.66072214
138Dehydration (HP:0001944)1.64937393
139Furrowed tongue (HP:0000221)1.64637079
140Lower limb amyotrophy (HP:0007210)1.64379100
141Type 1 muscle fiber predominance (HP:0003803)1.63427250
142Labial hypoplasia (HP:0000066)1.62321032
143Ulnar deviation of the wrist (HP:0003049)1.61053024
144Fasciculations (HP:0002380)1.60986759
145Protrusio acetabuli (HP:0003179)1.60852531
146Myopathic facies (HP:0002058)1.60595394
147Hamartoma (HP:0010566)1.59834413
148Difficulty running (HP:0009046)1.59784797
149Nasolacrimal duct obstruction (HP:0000579)1.56937489
150Sex reversal (HP:0012245)1.56511458
151Abnormal sex determination (HP:0012244)1.56511458
152Asymmetric septal hypertrophy (HP:0001670)1.55941764
153Sudden death (HP:0001699)1.55727643
154Absent eyelashes (HP:0000561)1.55241806
155Absent frontal sinuses (HP:0002688)1.53674015
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.52880907
157Cystic liver disease (HP:0006706)1.52621247
158Pancreatic cysts (HP:0001737)1.50163836
159Tubulointerstitial nephritis (HP:0001970)1.49036953
160Fetal akinesia sequence (HP:0001989)1.49009614
161Abnormality of the middle phalanges of the toes (HP:0010183)1.48633868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK35.62838044
2MAPK155.47917930
3MAP3K93.62696211
4MST1R3.50896669
5FER3.28029927
6LATS22.88817986
7RPS6KB22.62358928
8NTRK32.32568884
9EPHA22.27853281
10LATS12.07438373
11PLK42.06194868
12MAP3K22.03716951
13MST42.02868084
14EPHA41.97412491
15MOS1.90280056
16TXK1.88066059
17GRK51.77590892
18STK241.75673875
19NTRK21.74570031
20MAP3K31.65111604
21TAOK11.64571110
22EEF2K1.48097391
23NME11.47624856
24MAPK121.47329388
25PRKD31.42762853
26PNCK1.41905522
27RIPK41.41530312
28KSR21.41356390
29TYRO31.39722707
30PLK21.38323800
31MAP2K71.37886184
32EPHB21.36753213
33TRPM71.36717346
34DAPK21.36564148
35TIE11.36344752
36CDK191.36093767
37TGFBR21.35511400
38PAK61.35464757
39RIPK11.32810102
40MYLK1.31067313
41MAP4K21.28877681
42INSRR1.27459141
43MAP2K41.24160179
44NEK11.23740063
45BCR1.23482727
46CASK1.22389691
47PINK11.21979337
48STK381.16009880
49AKT31.14483653
50MET1.12599704
51ARAF1.11219145
52PTK2B1.02439496
53UHMK11.00970898
54PHKG11.00817713
55PHKG21.00817713
56STK38L1.00634863
57MAP3K120.99982240
58MINK10.99498285
59ADRBK20.99353850
60STK110.99047786
61ABL20.98827053
62PAK30.97142864
63MAPKAPK50.96650098
64MAP3K140.93304256
65ALK0.90489303
66MUSK0.89943051
67MAP3K10.89246103
68CDK120.88818019
69LIMK10.87037796
70ROCK10.85713455
71PRKCG0.85604593
72MAP2K60.85206650
73TTN0.83136527
74EPHA30.82146567
75MAP3K70.81516554
76PRKD20.81060164
77NTRK10.80626759
78MAP3K40.80106212
79NEK60.79136930
80MARK10.78907028
81DDR20.78142301
82MAP2K10.77663081
83SGK4940.77361858
84SGK2230.77361858
85CAMK2G0.75991783
86MAPK70.74114189
87DYRK1B0.73935435
88CDC42BPA0.73893872
89GRK70.73538446
90PIK3CG0.72741967
91BMX0.71874184
92PRKCI0.71188871
93FGFR20.70341712
94DMPK0.69931459
95FGFR10.68782821
96GRK10.66370111
97MAP3K130.66105305
98CAMK10.65744898
99PTK20.65256327
100FGR0.64483132
101TNK20.63706922
102MAP3K110.63590586
103MAPKAPK20.59881524
104LMTK20.59622517
105CDK50.56601359
106CSNK1E0.56114238
107SGK10.53534314
108PKN10.51805535
109ERBB30.51394762
110TGFBR10.49691647
111PRKG10.48847968
112PRKD10.47397172
113ADRBK10.47256304
114ERBB20.46824397
115FGFR30.46663513
116OBSCN0.46631998
117LRRK20.46213352
118MAP3K60.46192190
119RPS6KA10.45514421
120PRKAA20.44956797
121PAK10.44085889
122KIT0.43621092
123PBK0.43369638
124HIPK20.43060663
125CSNK1D0.42980470
126STK160.42618021
127DYRK30.41995013
128PDGFRA0.41041849
129PTK60.40877212
130PRKACA0.40291343
131ROCK20.39538169
132CAMKK10.38891824
133DYRK1A0.38844615
134STK100.37494355
135MAPK130.37205712
136PIK3CA0.37034586
137RPS6KA40.36623312
138CDK60.35456154
139KSR10.34487606
140TESK10.34045497
141AURKA0.33931538
142CDK30.32867284
143PRKCA0.32505583
144MARK20.32279598
145PRKCD0.31838365
146PRKCE0.31491764
147JAK20.30930989
148CAMK2A0.30140931
149ERBB40.29927334

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.14568373
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.66230480
3Sphingolipid metabolism_Homo sapiens_hsa006002.37578521
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14811782
5Chemical carcinogenesis_Homo sapiens_hsa052042.10650854
6Cardiac muscle contraction_Homo sapiens_hsa042602.10166728
7Linoleic acid metabolism_Homo sapiens_hsa005912.06986867
8beta-Alanine metabolism_Homo sapiens_hsa004102.00420482
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98197967
10Tyrosine metabolism_Homo sapiens_hsa003501.91666214
11Huntingtons disease_Homo sapiens_hsa050161.87878533
12Arachidonic acid metabolism_Homo sapiens_hsa005901.86043718
13GnRH signaling pathway_Homo sapiens_hsa049121.84761324
14Long-term potentiation_Homo sapiens_hsa047201.75808228
15Retinol metabolism_Homo sapiens_hsa008301.73771786
16Nicotine addiction_Homo sapiens_hsa050331.70911662
17Serotonergic synapse_Homo sapiens_hsa047261.70255081
18Amphetamine addiction_Homo sapiens_hsa050311.69729459
19Synaptic vesicle cycle_Homo sapiens_hsa047211.67970707
20Olfactory transduction_Homo sapiens_hsa047401.64777229
21Salivary secretion_Homo sapiens_hsa049701.64464147
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59480625
23Phenylalanine metabolism_Homo sapiens_hsa003601.57275222
24Gastric acid secretion_Homo sapiens_hsa049711.54671386
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47222090
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47175639
27Renin secretion_Homo sapiens_hsa049241.46579756
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44853294
29VEGF signaling pathway_Homo sapiens_hsa043701.42299658
30Fatty acid degradation_Homo sapiens_hsa000711.42070262
31Melanogenesis_Homo sapiens_hsa049161.40335603
32Hippo signaling pathway_Homo sapiens_hsa043901.38250150
33Glutamatergic synapse_Homo sapiens_hsa047241.38165240
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36018442
35Tight junction_Homo sapiens_hsa045301.33630937
36Calcium signaling pathway_Homo sapiens_hsa040201.31193021
37Arginine and proline metabolism_Homo sapiens_hsa003301.30729933
38Dorso-ventral axis formation_Homo sapiens_hsa043201.29470738
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28540204
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27185739
41Basal cell carcinoma_Homo sapiens_hsa052171.26956802
42Circadian entrainment_Homo sapiens_hsa047131.26663291
43Fatty acid biosynthesis_Homo sapiens_hsa000611.25055091
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.23636678
45Axon guidance_Homo sapiens_hsa043601.23421970
46Oxytocin signaling pathway_Homo sapiens_hsa049211.23106619
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22605879
48Oxidative phosphorylation_Homo sapiens_hsa001901.21074904
49Ether lipid metabolism_Homo sapiens_hsa005651.19808493
50Sphingolipid signaling pathway_Homo sapiens_hsa040711.19760130
51Long-term depression_Homo sapiens_hsa047301.19114297
52p53 signaling pathway_Homo sapiens_hsa041151.16893366
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16666305
54Alzheimers disease_Homo sapiens_hsa050101.16563199
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15671152
56Fatty acid elongation_Homo sapiens_hsa000621.14523640
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13529593
58Dopaminergic synapse_Homo sapiens_hsa047281.10015244
59Hedgehog signaling pathway_Homo sapiens_hsa043401.09102448
60ErbB signaling pathway_Homo sapiens_hsa040121.08153019
61Estrogen signaling pathway_Homo sapiens_hsa049151.06952822
62Taste transduction_Homo sapiens_hsa047421.05879984
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04337876
64Glutathione metabolism_Homo sapiens_hsa004801.02437098
65Ras signaling pathway_Homo sapiens_hsa040141.01339615
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01091843
67Pancreatic secretion_Homo sapiens_hsa049721.00817644
68Phototransduction_Homo sapiens_hsa047440.99017744
69Tryptophan metabolism_Homo sapiens_hsa003800.96667796
70GABAergic synapse_Homo sapiens_hsa047270.94670217
71Adherens junction_Homo sapiens_hsa045200.94467475
72Glioma_Homo sapiens_hsa052140.94128729
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.93951441
74Insulin secretion_Homo sapiens_hsa049110.93419552
75Bladder cancer_Homo sapiens_hsa052190.91752511
76Nitrogen metabolism_Homo sapiens_hsa009100.91689721
77Cocaine addiction_Homo sapiens_hsa050300.88551238
78Cholinergic synapse_Homo sapiens_hsa047250.88195400
79MAPK signaling pathway_Homo sapiens_hsa040100.86774488
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86082737
81PPAR signaling pathway_Homo sapiens_hsa033200.85904451
82cAMP signaling pathway_Homo sapiens_hsa040240.84817681
83Gap junction_Homo sapiens_hsa045400.84729115
84Wnt signaling pathway_Homo sapiens_hsa043100.82950166
85Ribosome_Homo sapiens_hsa030100.82718162
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81693307
87MicroRNAs in cancer_Homo sapiens_hsa052060.80832438
88Parkinsons disease_Homo sapiens_hsa050120.80482818
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78509533
90Arginine biosynthesis_Homo sapiens_hsa002200.78007675
91Rap1 signaling pathway_Homo sapiens_hsa040150.77912399
92Morphine addiction_Homo sapiens_hsa050320.75914597
93Inositol phosphate metabolism_Homo sapiens_hsa005620.75853311
94Collecting duct acid secretion_Homo sapiens_hsa049660.75758636
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.75047134
96Choline metabolism in cancer_Homo sapiens_hsa052310.74992256
97Proteoglycans in cancer_Homo sapiens_hsa052050.74548722
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73042952
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69062869
100Circadian rhythm_Homo sapiens_hsa047100.68911907
101ECM-receptor interaction_Homo sapiens_hsa045120.68631208
102Melanoma_Homo sapiens_hsa052180.68064770
103Oocyte meiosis_Homo sapiens_hsa041140.68049577
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67129126
105Peroxisome_Homo sapiens_hsa041460.66441241
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65968745
107Histidine metabolism_Homo sapiens_hsa003400.65820994
108Folate biosynthesis_Homo sapiens_hsa007900.65078494
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.64087967
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60941301
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60890540
112Amoebiasis_Homo sapiens_hsa051460.60508881
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59207624
114TGF-beta signaling pathway_Homo sapiens_hsa043500.58805779
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56385109
116Ovarian steroidogenesis_Homo sapiens_hsa049130.56335853
117Endometrial cancer_Homo sapiens_hsa052130.54270044
118Endocytosis_Homo sapiens_hsa041440.53953085
119Thyroid cancer_Homo sapiens_hsa052160.53578064
120Protein digestion and absorption_Homo sapiens_hsa049740.53062303
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52762623
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52391986
123Dilated cardiomyopathy_Homo sapiens_hsa054140.50905566
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.50537918
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49546390
126Type II diabetes mellitus_Homo sapiens_hsa049300.48844615
127Pathways in cancer_Homo sapiens_hsa052000.48803567
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.48688255
129mTOR signaling pathway_Homo sapiens_hsa041500.47519381
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46965222
131Small cell lung cancer_Homo sapiens_hsa052220.44776216
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44188323
133Notch signaling pathway_Homo sapiens_hsa043300.42713875
134Butanoate metabolism_Homo sapiens_hsa006500.42199655
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42142466
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.40578961
137Focal adhesion_Homo sapiens_hsa045100.36381059
138Complement and coagulation cascades_Homo sapiens_hsa046100.36247295
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33340643

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