ANKRD36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.92439186
2piRNA metabolic process (GO:0034587)9.64973735
3reproduction (GO:0000003)9.54343586
4motile cilium assembly (GO:0044458)9.51800649
5spermatid development (GO:0007286)9.13849276
6male meiosis (GO:0007140)8.67780243
7cilium movement (GO:0003341)8.50680414
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.39632717
9synaptonemal complex organization (GO:0070193)7.99283587
10regulation of cilium movement (GO:0003352)7.80906008
11synaptonemal complex assembly (GO:0007130)7.73745786
12single fertilization (GO:0007338)7.57729142
13sperm capacitation (GO:0048240)6.87388293
14fertilization (GO:0009566)6.44280683
15DNA methylation involved in gamete generation (GO:0043046)6.10982301
16negative regulation of inclusion body assembly (GO:0090084)6.01522528
17spermatogenesis (GO:0007283)5.99374058
18male gamete generation (GO:0048232)5.97307141
19male meiosis I (GO:0007141)5.69357349
20microtubule depolymerization (GO:0007019)5.68583213
21gamete generation (GO:0007276)5.50034746
22chromosome organization involved in meiosis (GO:0070192)5.46153925
23ventricular system development (GO:0021591)5.39233370
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.30638642
25organic cation transport (GO:0015695)5.28551721
26germ cell development (GO:0007281)5.25322780
27meiotic nuclear division (GO:0007126)5.07501931
28regulation of inclusion body assembly (GO:0090083)4.96143032
29cell recognition (GO:0008037)4.90058024
30calcium ion-dependent exocytosis (GO:0017156)4.84722281
31seminiferous tubule development (GO:0072520)4.70315668
32meiosis I (GO:0007127)4.61795155
33regulation of microtubule-based movement (GO:0060632)4.58065173
34microtubule severing (GO:0051013)4.54215421
35spermatid nucleus differentiation (GO:0007289)4.32789222
36multicellular organismal reproductive process (GO:0048609)4.31935280
37monoubiquitinated protein deubiquitination (GO:0035520)4.30932585
38meiotic cell cycle (GO:0051321)4.30215282
39protein localization to cilium (GO:0061512)4.17076204
40presynaptic membrane assembly (GO:0097105)4.15473840
41pyrimidine nucleobase catabolic process (GO:0006208)4.14045167
42left/right pattern formation (GO:0060972)4.09105679
43genitalia morphogenesis (GO:0035112)3.90787815
44establishment of protein localization to Golgi (GO:0072600)3.81211535
45chaperone-mediated protein complex assembly (GO:0051131)3.79929331
46presynaptic membrane organization (GO:0097090)3.79464041
47glycerol ether metabolic process (GO:0006662)3.78934607
48gene silencing by RNA (GO:0031047)3.63815999
49behavioral response to nicotine (GO:0035095)3.60025350
50intraciliary transport (GO:0042073)3.59652473
51neural tube formation (GO:0001841)3.51307919
52protein polyglutamylation (GO:0018095)3.50681952
53ether metabolic process (GO:0018904)3.49741705
54multicellular organismal development (GO:0007275)3.48380046
55central nervous system projection neuron axonogenesis (GO:0021952)3.47639039
56neuronal action potential (GO:0019228)3.47220976
57gamma-aminobutyric acid transport (GO:0015812)3.41813037
58nucleobase catabolic process (GO:0046113)3.41285142
59chromosome condensation (GO:0030261)3.40697625
60response to pheromone (GO:0019236)3.33247595
61auditory behavior (GO:0031223)3.33082355
62DNA packaging (GO:0006323)3.29914485
63synapsis (GO:0007129)3.29744206
64negative regulation of translation, ncRNA-mediated (GO:0040033)3.28775959
65regulation of translation, ncRNA-mediated (GO:0045974)3.28775959
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28775959
67meiotic cell cycle process (GO:1903046)3.26302357
68axoneme assembly (GO:0035082)3.26187767
69microtubule-based movement (GO:0007018)3.24829391
70protein targeting to Golgi (GO:0000042)3.22702284
71positive regulation of action potential (GO:0045760)3.22259385
72regulation of centriole replication (GO:0046599)3.21385113
73interkinetic nuclear migration (GO:0022027)3.20816161
74negative regulation of organelle assembly (GO:1902116)3.18792527
75carnitine transport (GO:0015879)3.18095459
76amino-acid betaine transport (GO:0015838)3.18095459
77behavioral response to ethanol (GO:0048149)3.16797945
78startle response (GO:0001964)3.16271141
79microtubule anchoring (GO:0034453)3.15460695
80central nervous system neuron axonogenesis (GO:0021955)3.15259276
81protein K11-linked deubiquitination (GO:0035871)3.13959104
82neuron cell-cell adhesion (GO:0007158)3.12450985
83mechanosensory behavior (GO:0007638)3.12027939
84centriole assembly (GO:0098534)3.11964647
85carnitine transmembrane transport (GO:1902603)3.11727933
86alditol metabolic process (GO:0019400)3.10921320
87regulation of action potential (GO:0098900)3.09835560
88histone H3-K4 trimethylation (GO:0080182)3.09628862
89regulation of spindle checkpoint (GO:0090231)3.08452623
90limb bud formation (GO:0060174)3.08190728
91cilium organization (GO:0044782)3.07211383
92centriole replication (GO:0007099)3.07139456
93lactate metabolic process (GO:0006089)3.05829912
94neurotransmitter-gated ion channel clustering (GO:0072578)3.05051116
95regulation of meiosis I (GO:0060631)3.04900074
96polyol catabolic process (GO:0046174)3.04538162
97retrograde transport, vesicle recycling within Golgi (GO:0000301)3.04283011
98ionotropic glutamate receptor signaling pathway (GO:0035235)3.03991060
99tachykinin receptor signaling pathway (GO:0007217)3.03870722
100glutamate receptor signaling pathway (GO:0007215)3.03275171
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00301442
102postsynaptic membrane organization (GO:0001941)2.99758761
103fucose catabolic process (GO:0019317)2.98642574
104L-fucose metabolic process (GO:0042354)2.98642574
105L-fucose catabolic process (GO:0042355)2.98642574
106replication fork processing (GO:0031297)2.97957742
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96958103
108nuclear pore complex assembly (GO:0051292)2.96662391
109microtubule polymerization or depolymerization (GO:0031109)2.96109471
110membrane depolarization during action potential (GO:0086010)2.94173926
111nucleoside diphosphate phosphorylation (GO:0006165)2.94161681
112regulation of pigment cell differentiation (GO:0050932)2.93372638
113cilium assembly (GO:0042384)2.93231318
114membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91034318
115cilium morphogenesis (GO:0060271)2.90985275
116protein refolding (GO:0042026)2.90436731
117negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90182339
118cerebral cortex radially oriented cell migration (GO:0021799)2.90072763
119cellular component assembly involved in morphogenesis (GO:0010927)2.88512474
120regulation of telomere maintenance (GO:0032204)2.87543648
121detection of light stimulus involved in visual perception (GO:0050908)2.87176953
122detection of light stimulus involved in sensory perception (GO:0050962)2.87176953
123mitotic sister chromatid cohesion (GO:0007064)2.85319828
124single strand break repair (GO:0000012)2.84667671
125synaptic transmission, glutamatergic (GO:0035249)2.84448040
126positive regulation of developmental pigmentation (GO:0048087)2.83589632
127photoreceptor cell maintenance (GO:0045494)2.78807953
128nucleus organization (GO:0006997)2.76355105
129nucleus localization (GO:0051647)2.76168810
130regulation of sarcomere organization (GO:0060297)2.76155695
131positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.75180813
132retinal cone cell development (GO:0046549)2.74919186
133glycerol metabolic process (GO:0006071)2.74129365
134GTP biosynthetic process (GO:0006183)2.72487457
135histone H3-K9 methylation (GO:0051567)2.71256093
136glycolytic process (GO:0006096)2.71047336
137regulation of protein polyubiquitination (GO:1902914)2.70480311
138axonal fasciculation (GO:0007413)2.69029303
139transmission of nerve impulse (GO:0019226)2.68916207
140neuron recognition (GO:0008038)2.67625519
141protein localization to Golgi apparatus (GO:0034067)2.67474987
142vocalization behavior (GO:0071625)2.67149107
143positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.66398668
144response to auditory stimulus (GO:0010996)2.65723302
145gene silencing (GO:0016458)2.64345136
146reflex (GO:0060004)2.62915313
147indolalkylamine metabolic process (GO:0006586)2.62287448
148protein localization to synapse (GO:0035418)2.62126098
149head development (GO:0060322)2.61843513
150cAMP catabolic process (GO:0006198)2.60875731
151neuron-neuron synaptic transmission (GO:0007270)2.60677783
152nonmotile primary cilium assembly (GO:0035058)2.60193312
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58794686
154sequestering of actin monomers (GO:0042989)2.57912150
155peptidyl-lysine trimethylation (GO:0018023)2.57849355
156hindbrain development (GO:0030902)2.57783094
157neuronal action potential propagation (GO:0019227)2.55389884
158retina layer formation (GO:0010842)2.54211666
159sympathetic nervous system development (GO:0048485)2.53623489
160positive regulation of dendritic spine morphogenesis (GO:0061003)2.52802028
161indole-containing compound catabolic process (GO:0042436)2.52556665
162indolalkylamine catabolic process (GO:0046218)2.52556665
163tryptophan catabolic process (GO:0006569)2.52556665
164action potential (GO:0001508)2.52436386
165cerebellar Purkinje cell differentiation (GO:0021702)2.50389471
166serotonin metabolic process (GO:0042428)2.49283626
167peptidyl-glutamic acid modification (GO:0018200)2.49097675
168sexual reproduction (GO:0019953)2.48792114
169cyclic nucleotide catabolic process (GO:0009214)2.48602510
170establishment of nucleus localization (GO:0040023)2.47345932
171regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.46893096
172otic vesicle formation (GO:0030916)2.45946394
173negative regulation of DNA repair (GO:0045738)2.44030344
174fusion of sperm to egg plasma membrane (GO:0007342)14.3048342
175cilium or flagellum-dependent cell motility (GO:0001539)13.9334826
176sperm motility (GO:0030317)12.2677596
177cell wall macromolecule catabolic process (GO:0016998)11.8851295
178cell wall macromolecule metabolic process (GO:0044036)11.8851295
179acrosome assembly (GO:0001675)11.7837676
180multicellular organism reproduction (GO:0032504)11.5592972
181sperm-egg recognition (GO:0035036)11.3973245
182plasma membrane fusion (GO:0045026)10.8933799
183axonemal dynein complex assembly (GO:0070286)10.5563478
184acrosome reaction (GO:0007340)10.4444558
185binding of sperm to zona pellucida (GO:0007339)10.2857393
186cell-cell recognition (GO:0009988)10.1974194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.67096684
2EZH2_22144423_ChIP-Seq_EOC_Human4.56835309
3GBX2_23144817_ChIP-Seq_PC3_Human3.93052806
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.89337629
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76026022
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74922838
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61210423
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51522747
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.47583502
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.45530789
11IGF1R_20145208_ChIP-Seq_DFB_Human2.42332938
12FUS_26573619_Chip-Seq_HEK293_Human2.37131630
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32474247
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30817339
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25971001
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20848135
17ZNF274_21170338_ChIP-Seq_K562_Hela2.14626776
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12721265
19P300_19829295_ChIP-Seq_ESCs_Human2.12636864
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.10221152
21EWS_26573619_Chip-Seq_HEK293_Human2.09774709
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09687364
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05278578
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.04799053
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01827831
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1207540
27SMAD4_21799915_ChIP-Seq_A2780_Human1.93943067
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87917437
29VDR_22108803_ChIP-Seq_LS180_Human1.87310734
30GATA1_26923725_Chip-Seq_HPCs_Mouse1.86559870
31ER_23166858_ChIP-Seq_MCF-7_Human1.86208928
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80893300
33STAT3_23295773_ChIP-Seq_U87_Human1.79783180
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77994007
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76780870
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.75831207
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.73403737
38* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68628219
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.66447278
40TCF4_23295773_ChIP-Seq_U87_Human1.66042752
41STAT1_17558387_ChIP-Seq_HELA_Human1.64331282
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.63706659
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62647559
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62322367
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59947968
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.59856512
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59716766
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58864478
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58614764
50AR_21572438_ChIP-Seq_LNCaP_Human1.58141012
51* AR_25329375_ChIP-Seq_VCAP_Human1.57244495
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.56014087
53BCAT_22108803_ChIP-Seq_LS180_Human1.55434012
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52213586
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51544072
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.51185155
57* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50989292
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.49640516
59FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48937596
60KDM2B_26808549_Chip-Seq_REH_Human1.46835776
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42905457
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42464535
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41203900
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.39919567
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39744221
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39725938
67CBP_20019798_ChIP-Seq_JUKART_Human1.39725938
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38344574
69TP53_16413492_ChIP-PET_HCT116_Human1.38050848
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37566866
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37230922
72RUNX2_22187159_ChIP-Seq_PCA_Human1.36355329
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33347367
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29495855
75TCF4_22108803_ChIP-Seq_LS180_Human1.27772759
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26346479
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25150550
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.25042362
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.23944381
80GATA3_21867929_ChIP-Seq_TH1_Mouse1.22309589
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.21991447
82* FLI1_21867929_ChIP-Seq_TH2_Mouse1.21304442
83* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20978618
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19502003
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18038552
86* CRX_20693478_ChIP-Seq_RETINA_Mouse1.17566754
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17123979
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.16470835
89REST_21632747_ChIP-Seq_MESCs_Mouse1.15865929
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15648925
91SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15518797
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.15061323
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14235453
94P53_21459846_ChIP-Seq_SAOS-2_Human1.13709213
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13705433
96DROSHA_22980978_ChIP-Seq_HELA_Human1.12673704
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.12088573
98GF1_26923725_Chip-Seq_HPCs_Mouse1.11617213
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10455374
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.10278602
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10065809
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09638761
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09445324
104RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08766070
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08707749
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.08611208
107P53_22387025_ChIP-Seq_ESCs_Mouse1.07528917
108AHR_22903824_ChIP-Seq_MCF-7_Human1.07457537
109* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06544573
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05754557
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05395477
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05395477
113TP53_22573176_ChIP-Seq_HFKS_Human1.05378829
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05353757
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05290818
116P300_18555785_Chip-Seq_ESCs_Mouse1.04943624
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.04492522
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.04354497
119* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04289120
120RNF2_27304074_Chip-Seq_NSC_Mouse1.04238861
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03587398
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02778642
123* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02738543
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.02511689
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02505798
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02070785
127RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01729374
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01121086
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00969295
130ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00683372
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99428950
132SPI1_26923725_Chip-Seq_HPCs_Mouse0.96957571
133STAT3_18555785_Chip-Seq_ESCs_Mouse0.96789298
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96514227
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.95828942
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95208551
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94888999
138ERG_20517297_ChIP-Seq_VCAP_Human0.94463871
139EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93146348
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90891105
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90825536
142PU1_27457419_Chip-Seq_LIVER_Mouse0.89622916
143LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88330830
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87976754
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87641847
146YY1_22570637_ChIP-Seq_MALME-3M_Human0.87601698
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.87331582
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86572535
149CTCF_18555785_Chip-Seq_ESCs_Mouse0.86254004
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.86093765
151SOX9_26525672_Chip-Seq_HEART_Mouse0.85895273
152NFYB_21822215_ChIP-Seq_K562_Human0.85670527
153PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85006456
154TAF15_26573619_Chip-Seq_HEK293_Human0.84293664
155NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82925984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05438257
2MP0001929_abnormal_gametogenesis5.62740809
3MP0008877_abnormal_DNA_methylation5.25634380
4MP0002210_abnormal_sex_determination3.83342992
5MP0003787_abnormal_imprinting3.61750901
6MP0002653_abnormal_ependyma_morphology3.35412311
7MP0002161_abnormal_fertility/fecundity3.28698819
8MP0001145_abnormal_male_reproductive3.22717551
9MP0000653_abnormal_sex_gland2.82040777
10MP0001968_abnormal_touch/_nociception2.67695891
11MP0003880_abnormal_central_pattern2.62922162
12MP0002735_abnormal_chemical_nociception2.50865422
13MP0001486_abnormal_startle_reflex2.20205840
14MP0009745_abnormal_behavioral_response2.10943631
15MP0005623_abnormal_meninges_morphology2.08729646
16MP0000778_abnormal_nervous_system2.05856498
17MP0005670_abnormal_white_adipose2.02558851
18MP0005410_abnormal_fertilization15.4202471
19MP0005646_abnormal_pituitary_gland1.98799628
20MP0003635_abnormal_synaptic_transmissio1.95454880
21MP0003121_genomic_imprinting1.95045679
22MP0004859_abnormal_synaptic_plasticity1.89904794
23MP0002272_abnormal_nervous_system1.88819372
24MP0004270_analgesia1.88631647
25MP0002160_abnormal_reproductive_system1.88099894
26MP0004142_abnormal_muscle_tone1.86113574
27MP0006276_abnormal_autonomic_nervous1.77694357
28MP0004924_abnormal_behavior1.76311809
29MP0005386_behavior/neurological_phenoty1.76311809
30MP0002822_catalepsy1.76264870
31MP0003195_calcinosis1.74490473
32MP0001529_abnormal_vocalization1.69185061
33MP0005645_abnormal_hypothalamus_physiol1.68459474
34MP0002734_abnormal_mechanical_nocicepti1.67092944
35MP0008057_abnormal_DNA_replication1.66006370
36MP0000631_abnormal_neuroendocrine_gland1.65964897
37MP0002064_seizures1.65624671
38MP0002067_abnormal_sensory_capabilities1.62275354
39MP0002063_abnormal_learning/memory/cond1.61936779
40MP0002572_abnormal_emotion/affect_behav1.61006825
41MP0004742_abnormal_vestibular_system1.57301413
42MP0003122_maternal_imprinting1.51319143
43MP0001485_abnormal_pinna_reflex1.50213066
44MP0002557_abnormal_social/conspecific_i1.48580975
45MP0002638_abnormal_pupillary_reflex1.48248776
46MP0004043_abnormal_pH_regulation1.45828154
47MP0006292_abnormal_olfactory_placode1.45306263
48MP0001188_hyperpigmentation1.44114291
49MP0003646_muscle_fatigue1.43287107
50MP0008058_abnormal_DNA_repair1.42925154
51MP0001970_abnormal_pain_threshold1.41476314
52MP0010386_abnormal_urinary_bladder1.40961459
53MP0004885_abnormal_endolymph1.40100863
54MP0002282_abnormal_trachea_morphology1.36699256
55MP0005174_abnormal_tail_pigmentation1.34302019
56MP0001986_abnormal_taste_sensitivity1.34002322
57MP0005423_abnormal_somatic_nervous1.31560304
58MP0008872_abnormal_physiological_respon1.30626742
59MP0002184_abnormal_innervation1.30361020
60MP0002733_abnormal_thermal_nociception1.29286980
61MP0004233_abnormal_muscle_weight1.26874272
62MP0001501_abnormal_sleep_pattern1.26642616
63MP0004145_abnormal_muscle_electrophysio1.25332604
64MP0010094_abnormal_chromosome_stability1.21128482
65MP0000955_abnormal_spinal_cord1.20639656
66MP0009046_muscle_twitch1.19562916
67MP0005187_abnormal_penis_morphology1.17866800
68MP0002751_abnormal_autonomic_nervous1.17629745
69MP0002837_dystrophic_cardiac_calcinosis1.15467863
70MP0005647_abnormal_sex_gland1.15216461
71MP0002095_abnormal_skin_pigmentation1.13268256
72MP0002882_abnormal_neuron_morphology1.12284872
73MP0008995_early_reproductive_senescence1.06902539
74MP0003890_abnormal_embryonic-extraembry1.04500359
75MP0001984_abnormal_olfaction1.03911517
76MP0002752_abnormal_somatic_nervous1.02209705
77MP0001765_abnormal_ion_homeostasis1.00113332
78MP0002938_white_spotting0.99580062
79MP0005389_reproductive_system_phenotype0.97666146
80MP0001440_abnormal_grooming_behavior0.95092236
81MP0004147_increased_porphyrin_level0.90875294
82MP0000015_abnormal_ear_pigmentation0.89248425
83MP0003011_delayed_dark_adaptation0.88824517
84MP0002876_abnormal_thyroid_physiology0.83613316
85MP0003786_premature_aging0.83501298
86MP0000372_irregular_coat_pigmentation0.83113125
87MP0003937_abnormal_limbs/digits/tail_de0.83084362
88MP0000383_abnormal_hair_follicle0.78955594
89MP0008007_abnormal_cellular_replicative0.77340261
90MP0002066_abnormal_motor_capabilities/c0.76004149
91MP0003136_yellow_coat_color0.75758525
92MP0001963_abnormal_hearing_physiology0.75348415
93MP0002234_abnormal_pharynx_morphology0.73471110
94MP0001905_abnormal_dopamine_level0.73461669
95MP0005084_abnormal_gallbladder_morpholo0.72364779
96MP0002102_abnormal_ear_morphology0.70729396
97MP0004215_abnormal_myocardial_fiber0.69665826
98MP0003137_abnormal_impulse_conducting0.68136498
99MP0003950_abnormal_plasma_membrane0.65519235
100MP0003111_abnormal_nucleus_morphology0.63890905
101MP0000358_abnormal_cell_content/0.63071979
102MP0005377_hearing/vestibular/ear_phenot0.62656321
103MP0003878_abnormal_ear_physiology0.62656321
104MP0000569_abnormal_digit_pigmentation0.60913697
105MP0010307_abnormal_tumor_latency0.58486920
106MP0002928_abnormal_bile_duct0.57711982
107MP0001545_abnormal_hematopoietic_system0.55682540
108MP0005397_hematopoietic_system_phenotyp0.55682540
109MP0003699_abnormal_female_reproductive0.55466184
110MP0005636_abnormal_mineral_homeostasis0.54895998
111MP0003115_abnormal_respiratory_system0.52579119
112MP0001119_abnormal_female_reproductive0.48528199
113MP0004808_abnormal_hematopoietic_stem0.47393415
114MP0001293_anophthalmia0.45235685
115MP0004134_abnormal_chest_morphology0.43972373
116MP0009278_abnormal_bone_marrow0.43724646
117MP0001324_abnormal_eye_pigmentation0.43716732
118MP0005551_abnormal_eye_electrophysiolog0.42746762
119MP0005666_abnormal_adipose_tissue0.41282171
120MP0005253_abnormal_eye_physiology0.41170977
121MP0001730_embryonic_growth_arrest0.40186118
122MP0004036_abnormal_muscle_relaxation0.39237406
123MP0002269_muscular_atrophy0.38906845
124MP0003077_abnormal_cell_cycle0.37299635
125MP0004019_abnormal_vitamin_homeostasis0.35162236
126MP0003329_amyloid_beta_deposits0.34516708
127MP0005391_vision/eye_phenotype0.34017554
128MP0002971_abnormal_brown_adipose0.33682479
129MP0001764_abnormal_homeostasis0.32999613
130MP0006036_abnormal_mitochondrial_physio0.31435609
131MP0000313_abnormal_cell_death0.31046302
132MP0009115_abnormal_fat_cell0.30272354
133MP0003861_abnormal_nervous_system0.24593706
134MP0001727_abnormal_embryo_implantation0.24411094
135MP0002084_abnormal_developmental_patter0.24383700
136MP0000427_abnormal_hair_cycle0.24209408
137MP0003633_abnormal_nervous_system0.22527498
138MP0001661_extended_life_span0.21308845
139MP0003879_abnormal_hair_cell0.21127347
140MP0002152_abnormal_brain_morphology0.20898118
141MP0003045_fibrosis0.20346977
142MP0002092_abnormal_eye_morphology0.19888294
143MP0005380_embryogenesis_phenotype0.18709095
144MP0001672_abnormal_embryogenesis/_devel0.18709095
145MP0001697_abnormal_embryo_size0.18549259
146MP0006035_abnormal_mitochondrial_morpho0.18539528
147MP0002139_abnormal_hepatobiliary_system0.18398065
148MP0004811_abnormal_neuron_physiology0.18350243
149MP0004133_heterotaxia0.18147670
150MP0001851_eye_inflammation0.17823281
151MP0002405_respiratory_system_inflammati0.17532364
152MP0003631_nervous_system_phenotype0.17341092
153MP0006072_abnormal_retinal_apoptosis0.15973251
154MP0000604_amyloidosis0.14812724
155MP0002169_no_abnormal_phenotype0.14406423
156MP0002873_normal_phenotype0.14152462
157MP0002736_abnormal_nociception_after0.14018199
158MP0002229_neurodegeneration0.13741697
159MP0003984_embryonic_growth_retardation0.13710733
160MP0002080_prenatal_lethality0.13486143
161MP0002132_abnormal_respiratory_system0.13376809
162MP0000432_abnormal_head_morphology0.13035491
163MP0008961_abnormal_basal_metabolism0.12640759
164MP0002970_abnormal_white_adipose0.12419332
165MP0003936_abnormal_reproductive_system0.12309796
166MP0005195_abnormal_posterior_eye0.12259042
167MP0000647_abnormal_sebaceous_gland0.12015173
168MP0001919_abnormal_reproductive_system0.11784943
169MP0000001_mammalian_phenotype0.11611320

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.50709235
2Abnormal respiratory motile cilium morphology (HP:0005938)9.04925335
3Abnormal respiratory epithelium morphology (HP:0012253)9.04925335
4Rhinitis (HP:0012384)7.98344343
5Abnormal ciliary motility (HP:0012262)7.73063719
6Chronic bronchitis (HP:0004469)7.36624815
7Nasal polyposis (HP:0100582)6.44913644
8Infertility (HP:0000789)6.33602687
9Abnormality of the nasal mucosa (HP:0000433)5.28717196
10Hyperventilation (HP:0002883)4.95166967
11Bronchiectasis (HP:0002110)4.64187255
12Bronchitis (HP:0012387)4.56715570
13Nephronophthisis (HP:0000090)4.38280348
14Pancreatic cysts (HP:0001737)3.83688610
15Male infertility (HP:0003251)3.58026704
16Recurrent sinusitis (HP:0011108)3.51847452
17Broad-based gait (HP:0002136)3.44974641
18Abnormality of the renal medulla (HP:0100957)3.37036491
19Febrile seizures (HP:0002373)3.36584818
20Recurrent otitis media (HP:0000403)3.32561498
21Volvulus (HP:0002580)3.31694376
22Protruding tongue (HP:0010808)3.29113321
23Gaze-evoked nystagmus (HP:0000640)3.28979231
24Focal motor seizures (HP:0011153)3.12901815
25Abnormal spermatogenesis (HP:0008669)3.11225011
26Chronic hepatic failure (HP:0100626)3.05852794
27Tubulointerstitial nephritis (HP:0001970)2.97415796
28Focal seizures (HP:0007359)2.92048048
29Drooling (HP:0002307)2.91748798
30Abnormality of the lower motor neuron (HP:0002366)2.90669538
31Gonadotropin excess (HP:0000837)2.86587184
32Genetic anticipation (HP:0003743)2.82792241
33Absent speech (HP:0001344)2.82015216
34Medial flaring of the eyebrow (HP:0010747)2.80741957
35Progressive cerebellar ataxia (HP:0002073)2.80336830
36Recurrent bronchitis (HP:0002837)2.70109407
37Excessive salivation (HP:0003781)2.64567700
38Molar tooth sign on MRI (HP:0002419)2.60527999
39Abnormality of midbrain morphology (HP:0002418)2.60527999
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.51540036
41Thyroiditis (HP:0100646)2.50650685
42Tubular atrophy (HP:0000092)2.50408100
43Renal cortical cysts (HP:0000803)2.44913614
44Atonic seizures (HP:0010819)2.43670193
45Epileptic encephalopathy (HP:0200134)2.42574229
46Impulsivity (HP:0100710)2.42019422
47Tubulointerstitial abnormality (HP:0001969)2.41027077
48Stomach cancer (HP:0012126)2.37510241
49Azoospermia (HP:0000027)2.36992812
50Inability to walk (HP:0002540)2.34787210
51Type II lissencephaly (HP:0007260)2.32631042
52Abnormality of the labia minora (HP:0012880)2.32203852
53Amyotrophic lateral sclerosis (HP:0007354)2.30139138
54Fibular hypoplasia (HP:0003038)2.29063261
55Dialeptic seizures (HP:0011146)2.27012210
56Widely spaced teeth (HP:0000687)2.25875049
57Lissencephaly (HP:0001339)2.25344496
58Congenital stationary night blindness (HP:0007642)2.24483298
59Tented upper lip vermilion (HP:0010804)2.23610742
60Intestinal atresia (HP:0011100)2.18764063
61Oligodactyly (hands) (HP:0001180)2.15598779
62Fair hair (HP:0002286)2.14589840
63Hemiparesis (HP:0001269)2.12965601
64Cupped ear (HP:0000378)2.08963879
65Postaxial foot polydactyly (HP:0001830)2.07144405
66Hepatoblastoma (HP:0002884)2.04660064
67Colon cancer (HP:0003003)2.01880199
68Narrow forehead (HP:0000341)2.00462726
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6876206
70Absent/shortened dynein arms (HP:0200106)12.9278350
71Dynein arm defect of respiratory motile cilia (HP:0012255)12.9278350
72Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98722637
73Progressive inability to walk (HP:0002505)1.97426045
74Neoplasm of the oral cavity (HP:0100649)1.95218170
75Attenuation of retinal blood vessels (HP:0007843)1.92470655
76Hypoplastic iliac wings (HP:0002866)1.92373573
77Stage 5 chronic kidney disease (HP:0003774)1.92279766
78Hypothermia (HP:0002045)1.90679681
79Hypoplastic ischia (HP:0003175)1.90067075
80Neoplasm of the adrenal cortex (HP:0100641)1.86685946
81Abnormality of the ischium (HP:0003174)1.86341141
82Absence seizures (HP:0002121)1.86106631
83Congenital hepatic fibrosis (HP:0002612)1.85330997
84Impaired proprioception (HP:0010831)1.84525446
85Bulbous nose (HP:0000414)1.84203296
86Tubulointerstitial fibrosis (HP:0005576)1.83374543
87Abnormality of chromosome stability (HP:0003220)1.83110186
88Anencephaly (HP:0002323)1.83033265
89Abnormality of the pubic bones (HP:0003172)1.82321278
90Chronic sinusitis (HP:0011109)1.82150113
91Patellar aplasia (HP:0006443)1.81975458
92Sclerocornea (HP:0000647)1.80234792
93Short foot (HP:0001773)1.79315645
94Abnormality of the renal cortex (HP:0011035)1.78884353
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77561331
96Short ribs (HP:0000773)1.77461942
97Congenital primary aphakia (HP:0007707)1.76490888
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.76452616
99Gait imbalance (HP:0002141)1.75468851
100Microglossia (HP:0000171)1.74800779
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.74187083
102Abnormality of the astrocytes (HP:0100707)1.73356338
103Astrocytoma (HP:0009592)1.73356338
104Absent frontal sinuses (HP:0002688)1.73163679
105Astigmatism (HP:0000483)1.72520118
106Male pseudohermaphroditism (HP:0000037)1.71726298
107Generalized hypopigmentation of hair (HP:0011358)1.70894596
108Abnormality of permanent molar morphology (HP:0011071)1.70876636
109Abnormality of the dental root (HP:0006486)1.70876636
110Taurodontia (HP:0000679)1.70876636
111Glioma (HP:0009733)1.70446160
112Abnormality of DNA repair (HP:0003254)1.70366383
113Prominent nasal bridge (HP:0000426)1.69656415
114Spastic tetraparesis (HP:0001285)1.69650157
115Renal dysplasia (HP:0000110)1.68892373
116Oculomotor apraxia (HP:0000657)1.68845008
117Exotropia (HP:0000577)1.68436473
118Optic nerve hypoplasia (HP:0000609)1.68384012
119Highly arched eyebrow (HP:0002553)1.68363787
120Preaxial hand polydactyly (HP:0001177)1.66589605
121Abnormal drinking behavior (HP:0030082)1.65688792
122Polydipsia (HP:0001959)1.65688792
123Supernumerary spleens (HP:0009799)1.65669101
124Aplasia/Hypoplasia of the patella (HP:0006498)1.64606012
125Specific learning disability (HP:0001328)1.64499685
126Cholecystitis (HP:0001082)1.64220933
127Abnormal gallbladder physiology (HP:0012438)1.64220933
128Facial cleft (HP:0002006)1.64144575
129Upper motor neuron abnormality (HP:0002127)1.63775105
130Heterotopia (HP:0002282)1.63697258
131Severe combined immunodeficiency (HP:0004430)1.63251518
132Postaxial hand polydactyly (HP:0001162)1.62683776
133Increased corneal curvature (HP:0100692)1.62541716
134Keratoconus (HP:0000563)1.62541716
135Abnormality of dentin (HP:0010299)1.60531759
136J-shaped sella turcica (HP:0002680)1.59992587
137Abnormality of molar morphology (HP:0011070)1.59716932
138Abnormality of molar (HP:0011077)1.59716932
139Absent epiphyses (HP:0010577)1.58166461
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58166461
141Abnormality of the dental pulp (HP:0006479)1.54829113
142Abnormality of renal excretion (HP:0011036)1.51339745
143Nephrogenic diabetes insipidus (HP:0009806)1.50950838
144Degeneration of anterior horn cells (HP:0002398)1.50266075
145Abnormality of the anterior horn cell (HP:0006802)1.50266075
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46776608
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.45782679
148Dyschromatopsia (HP:0007641)1.43843788
149Aplasia/Hypoplasia of the fibula (HP:0006492)1.43413113
150Median cleft lip (HP:0000161)1.41808331
151Cystic liver disease (HP:0006706)1.41571267
152Pancreatic fibrosis (HP:0100732)1.41482855
153Bell-shaped thorax (HP:0001591)1.41223554
154Aplasia/Hypoplasia of the lens (HP:0008063)1.39873301
155Abnormal biliary tract physiology (HP:0012439)1.39477877
156Bile duct proliferation (HP:0001408)1.39477877
157Short thorax (HP:0010306)1.36844031
158Abnormality of ocular smooth pursuit (HP:0000617)1.36256431
159Poor coordination (HP:0002370)1.34569791
160Deformed sella turcica (HP:0002681)1.33710441
161Breast carcinoma (HP:0003002)1.33420648
16211 pairs of ribs (HP:0000878)1.30671268
163Cerebellar dysplasia (HP:0007033)1.30260987
164Decreased central vision (HP:0007663)1.29753822
165Genital tract atresia (HP:0001827)1.28392165
166Vaginal atresia (HP:0000148)1.27537537
167Nephropathy (HP:0000112)1.22807041
168Broad distal phalanx of finger (HP:0009836)1.21105999
169Abnormality of saccadic eye movements (HP:0000570)1.19817068
170Pachygyria (HP:0001302)1.19460745
171Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.19289364
172True hermaphroditism (HP:0010459)1.16215510
173Short femoral neck (HP:0100864)1.15337432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.13132629
2PDK39.13132629
3PDK25.93673260
4FRK5.74758832
5TESK14.62183357
6CASK4.51234413
7PRKD33.71042762
8ICK3.21124233
9MARK13.08199409
10MAPK132.95757874
11MAP4K22.34034650
12WNK42.33468662
13PTK2B2.32305538
14PRKG22.30760449
15PNCK2.28879593
16STK392.25698854
17NUAK12.25200333
18TNIK2.25022505
19NTRK32.11635868
20SIK21.99283521
21TAOK31.94738920
22NEK21.82949408
23AKT31.58675210
24GRK11.56429825
25STK381.38805601
26ADRBK21.36322929
27PAK31.30902629
28MKNK21.30576408
29EPHA41.26464393
30BCR1.24400729
31ZAK1.21870071
32ACVR1B1.18966253
33INSRR1.14493056
34TEC1.10425080
35TLK11.10070367
36SGK21.09929133
37DYRK1B1.04281426
38WNK10.99189663
39PIK3CA0.95889909
40CAMKK20.94917129
41PDK10.94815559
42DYRK20.94574590
43CSNK1G20.92999461
44MAPK150.92387649
45CCNB10.90476004
46OXSR10.89862878
47STK30.89809884
48TYRO30.89506051
49FGFR20.83134902
50PLK20.82952751
51EPHA30.82403607
52ERBB30.82005071
53DAPK20.80973107
54PASK0.79759075
55CDC70.78577369
56MAP2K40.76706683
57SGK2230.75640415
58SGK4940.75640415
59CSNK1G10.74944942
60TTK0.73629486
61PLK40.72628300
62STK160.72157085
63WEE10.72140237
64PRKCE0.71788536
65DYRK30.71409914
66MINK10.70288438
67IRAK10.68117005
68CSNK1A1L0.66363697
69TRIM280.66218047
70OBSCN0.65859410
71ADRBK10.65427214
72CHEK20.63543088
73LMTK20.62008333
74TESK20.61156178
75CSNK1G30.60900376
76DYRK1A0.60135208
77TXK0.59548739
78SGK10.59452589
79CAMK2A0.56590686
80VRK10.54762524
81PINK10.53907283
82CHEK10.53406798
83CDK120.53001331
84CAMK1G0.52515691
85CAMK10.50351747
86ATR0.49204882
87BRD40.48605064
88MKNK10.47575955
89NLK0.47024567
90CAMK40.46196650
91FLT30.46097160
92STK38L0.44701093
93CDK50.42485229
94DMPK0.42014881
95EEF2K0.41532407
96PRKACA0.40045520
97UHMK10.38941869
98ERBB20.38487737
99PDPK10.37764481
100ATM0.37202325
101MAP2K60.36944217
102CSNK1A10.35639131
103MAP3K60.35632939
104TRPM70.35492484
105CSNK1E0.34175249
106BRSK20.33072784
107CAMK2B0.32811541
108PHKG20.32567185
109PHKG10.32567185
110PLK10.31032867
111PAK10.29810836
112MTOR0.28412064
113MUSK0.25395575
114BMPR1B0.25069693
115NTRK20.24093801
116PRKAA10.22054065
117RIPK40.20733073
118PRKCG0.20599310
119PAK20.20384200
120IRAK20.19809504
121NEK60.19256300
122CAMKK10.17984624
123RPS6KB10.16147794
124MAPKAPK50.15678548
125MARK20.13435474
126BRAF0.12011874
127BRSK10.11852893
128WNK30.09966521
129CSNK1D0.08396269
130MARK30.07760083
131CSNK2A10.07396689
132CDK10.07266475
133CDK20.06783247
134STK100.06620019
135PRKCQ0.06311473
136PRKG10.05061432
137GSK3B0.04893961
138YES10.04887435
139RIPK10.04882982
140MAP3K40.04581149
141CDK150.04457373
142PRKCZ0.04239323
143PRKACG0.04216358
144ZAP700.03420231
145CSNK2A20.03149382
146PKN10.02996974
147PRKDC0.02587485
148PDGFRB0.02331328
149MAPK80.02197022
150EGFR0.02086730
151CDK180.02063885
152RPS6KA10.01907672
153PAK40.01739281
154CDK30.01671702
155CDK11A0.01449475
156MAP3K100.01128405
157PRKACB0.00972598
158CDK40.00879844
159BUB10.00736297
160STK110.00177287
161AURKB-0.0191014
162MAP2K7-0.0190530
163RPS6KA3-0.0178675
164CDK14-0.0140133
165CDK6-0.0122880
166PRKCB-0.0110312
167CSF1R-0.0088902
168AURKA-0.0031851

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.89372739
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.24110380
3Pyruvate metabolism_Homo sapiens_hsa006204.12912874
4Nicotine addiction_Homo sapiens_hsa050333.97683889
5Fatty acid biosynthesis_Homo sapiens_hsa000613.39272082
6Propanoate metabolism_Homo sapiens_hsa006403.24713178
7Basal transcription factors_Homo sapiens_hsa030222.98495017
8Glucagon signaling pathway_Homo sapiens_hsa049222.77006506
9Pentose phosphate pathway_Homo sapiens_hsa000302.65271300
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57970899
11Selenocompound metabolism_Homo sapiens_hsa004502.56362263
12Linoleic acid metabolism_Homo sapiens_hsa005912.48166665
13Fanconi anemia pathway_Homo sapiens_hsa034602.47559578
14Dorso-ventral axis formation_Homo sapiens_hsa043202.34591676
15Phototransduction_Homo sapiens_hsa047442.24748130
16Glutamatergic synapse_Homo sapiens_hsa047242.17533291
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17101563
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11656617
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11222992
20Oocyte meiosis_Homo sapiens_hsa041142.07689117
21Glycerolipid metabolism_Homo sapiens_hsa005611.98826562
22Morphine addiction_Homo sapiens_hsa050321.97582037
23Butanoate metabolism_Homo sapiens_hsa006501.95039638
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91940540
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88328034
26Non-homologous end-joining_Homo sapiens_hsa034501.83854653
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.78077270
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.77427071
29Huntingtons disease_Homo sapiens_hsa050161.76107803
30Nitrogen metabolism_Homo sapiens_hsa009101.73595549
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72824243
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.72387711
33GABAergic synapse_Homo sapiens_hsa047271.72304932
34PPAR signaling pathway_Homo sapiens_hsa033201.66393161
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65181378
36Olfactory transduction_Homo sapiens_hsa047401.64605644
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.59046115
38Dopaminergic synapse_Homo sapiens_hsa047281.57555162
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.56484107
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53991514
41Amphetamine addiction_Homo sapiens_hsa050311.43586223
42Carbon metabolism_Homo sapiens_hsa012001.42641262
43Cocaine addiction_Homo sapiens_hsa050301.41685848
44Fructose and mannose metabolism_Homo sapiens_hsa000511.38930137
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38774476
46Long-term depression_Homo sapiens_hsa047301.37014912
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.36342783
48RNA transport_Homo sapiens_hsa030131.34866066
49Serotonergic synapse_Homo sapiens_hsa047261.32823149
50mRNA surveillance pathway_Homo sapiens_hsa030151.32630094
51Regulation of autophagy_Homo sapiens_hsa041401.26818572
52Cholinergic synapse_Homo sapiens_hsa047251.25371156
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24969184
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21015067
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.20685566
56Renin secretion_Homo sapiens_hsa049241.19124717
57Circadian rhythm_Homo sapiens_hsa047101.18065623
58Cardiac muscle contraction_Homo sapiens_hsa042601.16969250
59Antigen processing and presentation_Homo sapiens_hsa046121.14110442
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13264084
61Ether lipid metabolism_Homo sapiens_hsa005651.09752445
62Axon guidance_Homo sapiens_hsa043601.08745816
63Purine metabolism_Homo sapiens_hsa002301.08721031
64Fat digestion and absorption_Homo sapiens_hsa049751.05695660
65Mineral absorption_Homo sapiens_hsa049781.05510507
66Oxytocin signaling pathway_Homo sapiens_hsa049211.01617996
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99848939
68Biosynthesis of amino acids_Homo sapiens_hsa012300.99803308
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97138346
70Fatty acid metabolism_Homo sapiens_hsa012120.96503341
71Lysine degradation_Homo sapiens_hsa003100.90157963
72Fatty acid degradation_Homo sapiens_hsa000710.89369641
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.89254685
74Tryptophan metabolism_Homo sapiens_hsa003800.89224522
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85663451
76Ovarian steroidogenesis_Homo sapiens_hsa049130.84976453
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84221737
78Type II diabetes mellitus_Homo sapiens_hsa049300.84101821
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83774918
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82330521
81Glutathione metabolism_Homo sapiens_hsa004800.80163637
82ABC transporters_Homo sapiens_hsa020100.79959720
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77061881
84Caffeine metabolism_Homo sapiens_hsa002320.76994505
85Systemic lupus erythematosus_Homo sapiens_hsa053220.73005034
86Long-term potentiation_Homo sapiens_hsa047200.69642264
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66678375
88Protein export_Homo sapiens_hsa030600.66636136
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66236749
90Chemical carcinogenesis_Homo sapiens_hsa052040.65453057
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63872009
92RNA polymerase_Homo sapiens_hsa030200.62870497
93Estrogen signaling pathway_Homo sapiens_hsa049150.62606711
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62110554
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61627824
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60305260
97N-Glycan biosynthesis_Homo sapiens_hsa005100.59344618
98Collecting duct acid secretion_Homo sapiens_hsa049660.58457368
99Peroxisome_Homo sapiens_hsa041460.57547523
100Arachidonic acid metabolism_Homo sapiens_hsa005900.57459881
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.56842001
102Renin-angiotensin system_Homo sapiens_hsa046140.56128091
103Legionellosis_Homo sapiens_hsa051340.54292240
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53794512
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53184467
106Ras signaling pathway_Homo sapiens_hsa040140.53134741
107Calcium signaling pathway_Homo sapiens_hsa040200.51703717
108Homologous recombination_Homo sapiens_hsa034400.51077459
109MAPK signaling pathway_Homo sapiens_hsa040100.49056379
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.48879951
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.47590521
112Inositol phosphate metabolism_Homo sapiens_hsa005620.47334895
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46639139
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45657024
115Hedgehog signaling pathway_Homo sapiens_hsa043400.44844335
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42961449
117AMPK signaling pathway_Homo sapiens_hsa041520.42239565
118Primary immunodeficiency_Homo sapiens_hsa053400.41903351
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41832686
120VEGF signaling pathway_Homo sapiens_hsa043700.41409982
121Insulin secretion_Homo sapiens_hsa049110.40822446
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40281408
123Metabolic pathways_Homo sapiens_hsa011000.39078275
124Thyroid hormone synthesis_Homo sapiens_hsa049180.38813773
125Cell cycle_Homo sapiens_hsa041100.38565387
126Endocytosis_Homo sapiens_hsa041440.36896047
127Bile secretion_Homo sapiens_hsa049760.36748168
128Pyrimidine metabolism_Homo sapiens_hsa002400.36648337
129RNA degradation_Homo sapiens_hsa030180.36586384
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.36034664
131Nucleotide excision repair_Homo sapiens_hsa034200.34711949
132Gap junction_Homo sapiens_hsa045400.32106348
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32027676
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30618411
135Protein digestion and absorption_Homo sapiens_hsa049740.30398468
136Platelet activation_Homo sapiens_hsa046110.30302973
137Choline metabolism in cancer_Homo sapiens_hsa052310.27592844
138Taste transduction_Homo sapiens_hsa047420.27451412
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25351293
140Viral carcinogenesis_Homo sapiens_hsa052030.25296056
141Pancreatic secretion_Homo sapiens_hsa049720.23863113
142Synaptic vesicle cycle_Homo sapiens_hsa047210.23758983
143Alcoholism_Homo sapiens_hsa050340.23236346
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21670365
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.20766774
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.17419948
147B cell receptor signaling pathway_Homo sapiens_hsa046620.16761530
148Retinol metabolism_Homo sapiens_hsa008300.16190529
149cAMP signaling pathway_Homo sapiens_hsa040240.15548897
150Salivary secretion_Homo sapiens_hsa049700.14821227
151Circadian entrainment_Homo sapiens_hsa047130.13597806
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.13122239
153Wnt signaling pathway_Homo sapiens_hsa043100.12210242
154Gastric acid secretion_Homo sapiens_hsa049710.11931904
155Salmonella infection_Homo sapiens_hsa051320.10813548
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.08570272

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