ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	4.09911322
2	establishment of protein localization to Golgi (GO:0072600)	3.87799857
3	limb bud formation (GO:0060174)	3.86068131
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.82170786
5	protein K11-linked deubiquitination (GO:0035871)	3.68393873
6	pyrimidine nucleobase catabolic process (GO:0006208)	3.67528879
7	centriole replication (GO:0007099)	3.48584809
8	behavioral response to nicotine (GO:0035095)	3.46760220
9	response to pheromone (GO:0019236)	3.42113760
10	otic vesicle formation (GO:0030916)	3.40136411
11	presynaptic membrane assembly (GO:0097105)	3.38195558
12	protein targeting to Golgi (GO:0000042)	3.31808646
13	detection of light stimulus involved in visual perception (GO:0050908)	3.29665748
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.29665748
15	protein polyglutamylation (GO:0018095)	3.26760623
16	fucose catabolic process (GO:0019317)	3.23873572
17	L-fucose metabolic process (GO:0042354)	3.23873572
18	L-fucose catabolic process (GO:0042355)	3.23873572
19	behavioral response to ethanol (GO:0048149)	3.21058720
20	neuronal action potential (GO:0019228)	3.19868295
21	negative regulation of dendrite development (GO:2000171)	3.19551027
22	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.18508412
23	nucleobase catabolic process (GO:0046113)	3.12334549
24	histone H3-K9 methylation (GO:0051567)	3.12052539
25	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.11433191
26	regulation of sarcomere organization (GO:0060297)	3.08836064
27	indolalkylamine metabolic process (GO:0006586)	3.08357513
28	central nervous system projection neuron axonogenesis (GO:0021952)	3.06618926
29	presynaptic membrane organization (GO:0097090)	3.01683869
30	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.98088429
31	histone H3-K4 trimethylation (GO:0080182)	2.97385133
32	epithelial cilium movement (GO:0003351)	2.94384913
33	indole-containing compound catabolic process (GO:0042436)	2.94342372
34	indolalkylamine catabolic process (GO:0046218)	2.94342372
35	tryptophan catabolic process (GO:0006569)	2.94342372
36	positive regulation of developmental pigmentation (GO:0048087)	2.93676877
37	gamma-aminobutyric acid transport (GO:0015812)	2.93376753
38	central nervous system neuron axonogenesis (GO:0021955)	2.89301499
39	amine catabolic process (GO:0009310)	2.89241508
40	cellular biogenic amine catabolic process (GO:0042402)	2.89241508
41	negative regulation of mast cell activation (GO:0033004)	2.87995729
42	regulation of cilium movement (GO:0003352)	2.87815682
43	protein localization to Golgi apparatus (GO:0034067)	2.86376382
44	regulation of pigment cell differentiation (GO:0050932)	2.86093401
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.80943047
46	regulation of telomere maintenance (GO:0032204)	2.80857334
47	axoneme assembly (GO:0035082)	2.80371820
48	protein localization to cilium (GO:0061512)	2.78212188
49	neuron cell-cell adhesion (GO:0007158)	2.77933232
50	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.74852764
51	regulation of translation, ncRNA-mediated (GO:0045974)	2.74852764
52	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.74852764
53	membrane depolarization during action potential (GO:0086010)	2.72173186
54	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.71279806
55	cAMP catabolic process (GO:0006198)	2.70684171
56	interkinetic nuclear migration (GO:0022027)	2.68749534
57	cilium morphogenesis (GO:0060271)	2.68184717
58	cilium organization (GO:0044782)	2.68172186
59	intraciliary transport (GO:0042073)	2.66122038
60	startle response (GO:0001964)	2.66103074
61	cilium assembly (GO:0042384)	2.64497327
62	photoreceptor cell maintenance (GO:0045494)	2.64435886
63	glutamate receptor signaling pathway (GO:0007215)	2.64204693
64	sympathetic nervous system development (GO:0048485)	2.63687647
65	regulation of dendritic spine morphogenesis (GO:0061001)	2.63312003
66	tryptophan metabolic process (GO:0006568)	2.62735141
67	microtubule anchoring (GO:0034453)	2.62682328
68	mechanosensory behavior (GO:0007638)	2.62655464
69	embryonic epithelial tube formation (GO:0001838)	2.62384628
70	monoubiquitinated protein deubiquitination (GO:0035520)	2.62206566
71	cerebral cortex radially oriented cell migration (GO:0021799)	2.61638737
72	DNA double-strand break processing (GO:0000729)	2.61372936
73	retinal cone cell development (GO:0046549)	2.59537671
74	peptidyl-lysine trimethylation (GO:0018023)	2.59370668
75	neurotransmitter-gated ion channel clustering (GO:0072578)	2.57367675
76	auditory behavior (GO:0031223)	2.56542028
77	regulation of glucokinase activity (GO:0033131)	2.54572234
78	regulation of hexokinase activity (GO:1903299)	2.54572234
79	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.54511490
80	replication fork processing (GO:0031297)	2.54327536
81	transepithelial transport (GO:0070633)	2.53518090
82	cyclic nucleotide catabolic process (GO:0009214)	2.53404864
83	eye photoreceptor cell differentiation (GO:0001754)	2.49957194
84	photoreceptor cell differentiation (GO:0046530)	2.49957194
85	cilium movement (GO:0003341)	2.49608703
86	piRNA metabolic process (GO:0034587)	2.48229024
87	protein prenylation (GO:0018342)	2.47382338
88	prenylation (GO:0097354)	2.47382338
89	histone H3-K9 modification (GO:0061647)	2.46978584
90	regulation of action potential (GO:0098900)	2.44628352
91	negative regulation of dendrite morphogenesis (GO:0050774)	2.38959986
92	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.38934583
93	pyrimidine dimer repair (GO:0006290)	2.38462489
94	epithelial tube formation (GO:0072175)	2.37507611
95	synaptic transmission, glutamatergic (GO:0035249)	2.36402523
96	regulation of acrosome reaction (GO:0060046)	2.35879389
97	postsynaptic membrane organization (GO:0001941)	2.35617687
98	vocalization behavior (GO:0071625)	2.35178564
99	alkaloid metabolic process (GO:0009820)	2.34409912
100	oxidative demethylation (GO:0070989)	2.34205786

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.72559285
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.45250242
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.01229836
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00243789
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.90217644
6	VDR_22108803_ChIP-Seq_LS180_Human	2.88191481
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.71946219
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.66728340
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.55130428
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.52095485
11	FUS_26573619_Chip-Seq_HEK293_Human	2.49670403
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.47043507
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37086616
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31433532
15	P300_19829295_ChIP-Seq_ESCs_Human	2.15133076
16	EWS_26573619_Chip-Seq_HEK293_Human	2.10822964
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.09817003
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.09311741
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06860253
20	ER_23166858_ChIP-Seq_MCF-7_Human	2.03938594
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.00684263
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93210786
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92664111
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84207659
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82131977
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73912344
27	STAT3_23295773_ChIP-Seq_U87_Human	1.73523912
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.71184395
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69287639
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68300717
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.68300717
32	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.67322714
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.65111224
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.61467288
35	TCF4_23295773_ChIP-Seq_U87_Human	1.60713998
36	AR_25329375_ChIP-Seq_VCAP_Human	1.58644480
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57759154
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57759154
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57082091
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56553303
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55655906
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.55144604
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54933670
44	AR_21572438_ChIP-Seq_LNCaP_Human	1.50056951
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48480425
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45272923
47	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.44696338
48	TP53_16413492_ChIP-PET_HCT116_Human	1.40020769
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39762837
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38008427
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37991278
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.32589469
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32554212
54	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.32415536
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31808772
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30954521
57	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.30023148
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29745859
59	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29546235
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28025583
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25379353
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25025594
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.24592647
64	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.24558767
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22533279
66	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22198849
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22058076
68	RXR_22108803_ChIP-Seq_LS180_Human	1.21857529
69	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20070467
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.20047295
71	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.19131357
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18909330
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18708735
74	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17624784
75	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17597260
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17135984
77	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17011090
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16453952
79	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.16181290
80	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.14574247
81	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14327626
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.13531306
83	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11875882
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11875882
85	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.10110218
86	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10062791
87	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09791471
88	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.07826474
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07752431
90	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.07731977
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.07311288
92	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06847014
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05924386
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04848207
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03657335
96	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.01849053
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01569580
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01220753
99	KDM2B_26808549_Chip-Seq_REH_Human	1.00781446
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00679511

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.63397037
2	MP0003787_abnormal_imprinting	3.39814543
3	MP0008057_abnormal_DNA_replication	3.16182154
4	MP0003880_abnormal_central_pattern	2.94666100
5	MP0008877_abnormal_DNA_methylation	2.83635521
6	MP0002735_abnormal_chemical_nociception	2.46755172
7	MP0001968_abnormal_touch/_nociception	2.43985912
8	MP0005551_abnormal_eye_electrophysiolog	2.15666504
9	MP0009046_muscle_twitch	2.13233979
10	MP0002736_abnormal_nociception_after	2.05865039
11	MP0005646_abnormal_pituitary_gland	2.05242025
12	MP0006276_abnormal_autonomic_nervous	2.04522826
13	MP0003195_calcinosis	2.04409948
14	MP0009745_abnormal_behavioral_response	1.96633539
15	MP0001486_abnormal_startle_reflex	1.88039828
16	MP0010386_abnormal_urinary_bladder	1.83153263
17	MP0003121_genomic_imprinting	1.77658139
18	MP0000778_abnormal_nervous_system	1.73999154
19	MP0002272_abnormal_nervous_system	1.70175728
20	MP0005645_abnormal_hypothalamus_physiol	1.69044295
21	MP0002163_abnormal_gland_morphology	1.67360043
22	MP0008872_abnormal_physiological_respon	1.65481210
23	MP0001529_abnormal_vocalization	1.63506548
24	MP0003635_abnormal_synaptic_transmissio	1.59326854
25	MP0000631_abnormal_neuroendocrine_gland	1.58212528
26	MP0004924_abnormal_behavior	1.57155117
27	MP0005386_behavior/neurological_phenoty	1.57155117
28	MP0004043_abnormal_pH_regulation	1.54908599
29	MP0004142_abnormal_muscle_tone	1.54513686
30	MP0001984_abnormal_olfaction	1.51742216
31	MP0002102_abnormal_ear_morphology	1.47568772
32	MP0002822_catalepsy	1.45949221
33	MP0001485_abnormal_pinna_reflex	1.43833300
34	MP0004270_analgesia	1.43670959
35	MP0001501_abnormal_sleep_pattern	1.41645581
36	MP0002928_abnormal_bile_duct	1.40785076
37	MP0008058_abnormal_DNA_repair	1.39853130
38	MP0005670_abnormal_white_adipose	1.39135909
39	MP0002572_abnormal_emotion/affect_behav	1.37647294
40	MP0002067_abnormal_sensory_capabilities	1.36896664
41	MP0002876_abnormal_thyroid_physiology	1.34561704
42	MP0002557_abnormal_social/conspecific_i	1.33818068
43	MP0002064_seizures	1.32112794
44	MP0006072_abnormal_retinal_apoptosis	1.31528153
45	MP0005253_abnormal_eye_physiology	1.31475499
46	MP0002063_abnormal_learning/memory/cond	1.31189183
47	MP0002638_abnormal_pupillary_reflex	1.30919069
48	MP0006292_abnormal_olfactory_placode	1.30774562
49	MP0005174_abnormal_tail_pigmentation	1.26267220
50	MP0001970_abnormal_pain_threshold	1.24453516
51	MP0004742_abnormal_vestibular_system	1.22674930
52	MP0002751_abnormal_autonomic_nervous	1.21969191
53	MP0008995_early_reproductive_senescence	1.21912128
54	MP0002837_dystrophic_cardiac_calcinosis	1.21082338
55	MP0000372_irregular_coat_pigmentation	1.20906044
56	MP0003950_abnormal_plasma_membrane	1.20764932
57	MP0004885_abnormal_endolymph	1.17632821
58	MP0000427_abnormal_hair_cycle	1.17578297
59	MP0002733_abnormal_thermal_nociception	1.17533702
60	MP0004147_increased_porphyrin_level	1.16231024
61	MP0002734_abnormal_mechanical_nocicepti	1.13379095
62	MP0005220_abnormal_exocrine_pancreas	1.12236756
63	MP0002234_abnormal_pharynx_morphology	1.10385271
64	MP0005423_abnormal_somatic_nervous	1.09793148
65	MP0005379_endocrine/exocrine_gland_phen	1.09651390
66	MP0002184_abnormal_innervation	1.09595800
67	MP0004859_abnormal_synaptic_plasticity	1.08078706
68	MP0001986_abnormal_taste_sensitivity	1.01233443
69	MP0001188_hyperpigmentation	1.00497491
70	MP0002095_abnormal_skin_pigmentation	1.00485368
71	MP0003646_muscle_fatigue	0.99382846
72	MP0002752_abnormal_somatic_nervous	0.97631924
73	MP0000613_abnormal_salivary_gland	0.97218465
74	MP0002882_abnormal_neuron_morphology	0.95105558
75	MP0005187_abnormal_penis_morphology	0.94841639
76	MP0004133_heterotaxia	0.94044694
77	MP0003122_maternal_imprinting	0.93676139
78	MP0000955_abnormal_spinal_cord	0.92846080
79	MP0002282_abnormal_trachea_morphology	0.91011799
80	MP0005195_abnormal_posterior_eye	0.90403786
81	MP0002229_neurodegeneration	0.87446780
82	MP0005084_abnormal_gallbladder_morpholo	0.85593728
83	MP0002168_other_aberrant_phenotype	0.84517880
84	MP0003633_abnormal_nervous_system	0.84181716
85	MP0003045_fibrosis	0.80284760
86	MP0003937_abnormal_limbs/digits/tail_de	0.80258205
87	MP0003698_abnormal_male_reproductive	0.79697127
88	MP0002138_abnormal_hepatobiliary_system	0.78949025
89	MP0002938_white_spotting	0.78567117
90	MP0002653_abnormal_ependyma_morphology	0.78472034
91	MP0005075_abnormal_melanosome_morpholog	0.77759637
92	MP0000538_abnormal_urinary_bladder	0.76298497
93	MP0000647_abnormal_sebaceous_gland	0.74880423
94	MP0004145_abnormal_muscle_electrophysio	0.74259173
95	MP0003943_abnormal_hepatobiliary_system	0.73984907
96	MP0003252_abnormal_bile_duct	0.73748693
97	MP0004085_abnormal_heartbeat	0.73215655
98	MP0005410_abnormal_fertilization	0.73202284
99	MP0002160_abnormal_reproductive_system	0.72979884
100	MP0001963_abnormal_hearing_physiology	0.72015950

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.56043717
2	Pancreatic cysts (HP:0001737)	4.23779100
3	True hermaphroditism (HP:0010459)	4.20364435
4	Pancreatic fibrosis (HP:0100732)	3.91438912
5	Gaze-evoked nystagmus (HP:0000640)	3.67845526
6	Nephronophthisis (HP:0000090)	3.63862176
7	Genetic anticipation (HP:0003743)	3.60764554
8	Abnormality of midbrain morphology (HP:0002418)	3.59629619
9	Molar tooth sign on MRI (HP:0002419)	3.59629619
10	Volvulus (HP:0002580)	3.54215805
11	Abnormality of the renal cortex (HP:0011035)	3.46629920
12	Abnormality of the renal medulla (HP:0100957)	3.42949475
13	Progressive cerebellar ataxia (HP:0002073)	3.36027942
14	Febrile seizures (HP:0002373)	3.24999679
15	Broad-based gait (HP:0002136)	3.16778382
16	Renal cortical cysts (HP:0000803)	3.16278537
17	Chronic hepatic failure (HP:0100626)	3.15334626
18	Medial flaring of the eyebrow (HP:0010747)	3.04669234
19	Tubulointerstitial nephritis (HP:0001970)	3.00163603
20	Focal motor seizures (HP:0011153)	2.95136763
21	Absent speech (HP:0001344)	2.90790523
22	Atonic seizures (HP:0010819)	2.82820138
23	Cystic liver disease (HP:0006706)	2.80835007
24	Stomach cancer (HP:0012126)	2.76206925
25	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.72507821
26	Protruding tongue (HP:0010808)	2.70628875
27	Focal seizures (HP:0007359)	2.69776711
28	Gait imbalance (HP:0002141)	2.63306627
29	Lissencephaly (HP:0001339)	2.53012345
30	Type II lissencephaly (HP:0007260)	2.52903923
31	Widely spaced teeth (HP:0000687)	2.50243799
32	Congenital primary aphakia (HP:0007707)	2.45054985
33	Inability to walk (HP:0002540)	2.43013693
34	Drooling (HP:0002307)	2.41776298
35	Congenital stationary night blindness (HP:0007642)	2.38601207
36	Progressive inability to walk (HP:0002505)	2.32848486
37	Thyroiditis (HP:0100646)	2.32609148
38	Nephrogenic diabetes insipidus (HP:0009806)	2.31191260
39	Epileptic encephalopathy (HP:0200134)	2.27338478
40	Tented upper lip vermilion (HP:0010804)	2.26282106
41	Genital tract atresia (HP:0001827)	2.26056751
42	Dialeptic seizures (HP:0011146)	2.24166313
43	Congenital hepatic fibrosis (HP:0002612)	2.22220056
44	Postaxial foot polydactyly (HP:0001830)	2.19801209
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17728886
46	Pachygyria (HP:0001302)	2.16842612
47	Excessive salivation (HP:0003781)	2.16400962
48	Sclerocornea (HP:0000647)	2.11454839
49	Thyroid-stimulating hormone excess (HP:0002925)	2.08074419
50	Vaginal atresia (HP:0000148)	2.07799086
51	Hypoplastic iliac wings (HP:0002866)	2.07063446
52	Hypothermia (HP:0002045)	2.03534962
53	Attenuation of retinal blood vessels (HP:0007843)	2.02537485
54	Keratoconus (HP:0000563)	2.02001848
55	Increased corneal curvature (HP:0100692)	2.02001848
56	Anencephaly (HP:0002323)	2.01940723
57	Tubulointerstitial abnormality (HP:0001969)	2.00024407
58	Cerebellar dysplasia (HP:0007033)	1.99715582
59	Male pseudohermaphroditism (HP:0000037)	1.99338608
60	Tubular atrophy (HP:0000092)	1.95895010
61	Intestinal atresia (HP:0011100)	1.95500980
62	Fair hair (HP:0002286)	1.90649997
63	Postaxial hand polydactyly (HP:0001162)	1.89634673
64	Abnormality of the astrocytes (HP:0100707)	1.87464477
65	Astrocytoma (HP:0009592)	1.87464477
66	Optic nerve hypoplasia (HP:0000609)	1.87299471
67	Cupped ear (HP:0000378)	1.86469570
68	Poor coordination (HP:0002370)	1.84298833
69	Hemiparesis (HP:0001269)	1.82570817
70	Abnormality of the pons (HP:0007361)	1.82380348
71	Limb dystonia (HP:0002451)	1.80578091
72	Absence seizures (HP:0002121)	1.80378085
73	Small hand (HP:0200055)	1.78565435
74	Bulbous nose (HP:0000414)	1.76935665
75	Narrow forehead (HP:0000341)	1.76621529
76	Hip dysplasia (HP:0001385)	1.75892522
77	Abnormality of the labia minora (HP:0012880)	1.74568752
78	Short tibia (HP:0005736)	1.72747463
79	Chorioretinal atrophy (HP:0000533)	1.72212909
80	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.72162891
81	Glioma (HP:0009733)	1.71451198
82	Short foot (HP:0001773)	1.70202666
83	Dysdiadochokinesis (HP:0002075)	1.69691507
84	Oligodactyly (hands) (HP:0001180)	1.69491330
85	Astigmatism (HP:0000483)	1.69462530
86	Colon cancer (HP:0003003)	1.69048795
87	Abolished electroretinogram (ERG) (HP:0000550)	1.67313073
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.65222312
89	Urinary bladder sphincter dysfunction (HP:0002839)	1.63324094
90	Dyskinesia (HP:0100660)	1.62392996
91	Patellar aplasia (HP:0006443)	1.62183105
92	Sloping forehead (HP:0000340)	1.61470023
93	Generalized hypopigmentation of hair (HP:0011358)	1.61378749
94	Hypsarrhythmia (HP:0002521)	1.61368171
95	Specific learning disability (HP:0001328)	1.60167575
96	Highly arched eyebrow (HP:0002553)	1.60065318
97	Prominent nasal bridge (HP:0000426)	1.59161503
98	Hypoplasia of the pons (HP:0012110)	1.58967286
99	Short chin (HP:0000331)	1.58445444
100	Abnormality of B cell number (HP:0010975)	1.57297931

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.29796202
2	CASK	4.50395149
3	MAP4K2	3.13385892
4	MARK1	2.69446533
5	WNK3	2.41475712
6	TNIK	2.35209146
7	MAPK13	2.33406263
8	MAP3K4	2.21855947
9	GRK1	2.00644255
10	LMTK2	1.98663367
11	NUAK1	1.98515918
12	BMPR1B	1.96681798
13	TAOK3	1.86852541
14	ADRBK2	1.85056559
15	MST4	1.82311816
16	STK39	1.63250253
17	PINK1	1.58025391
18	MAP2K7	1.52404289
19	TRIM28	1.52328556
20	MKNK2	1.52055563
21	BCR	1.50650461
22	BRSK2	1.46019512
23	NTRK3	1.41253122
24	PAK3	1.37469794
25	ZAK	1.36325720
26	EPHA4	1.32282969
27	OXSR1	1.29715854
28	EPHA3	1.22696534
29	TEC	1.19958866
30	INSRR	1.15869397
31	CCNB1	1.15132289
32	SIK2	1.02713009
33	ERBB3	1.00062018
34	ACVR1B	0.99467474
35	PIK3CA	0.99455891
36	CAMKK2	0.96888124
37	CSNK1G2	0.96490296
38	CSNK1A1L	0.95379523
39	AKT3	0.94731048
40	STK38L	0.93327722
41	NTRK2	0.93091951
42	ADRBK1	0.91645530
43	PRKCE	0.91097440
44	EIF2AK3	0.88345484
45	DYRK2	0.87762218
46	TLK1	0.85524622
47	WNK4	0.84965017
48	CSNK1G3	0.84637010
49	PNCK	0.84103091
50	SGK2	0.84043729
51	CSNK1G1	0.83904348
52	TXK	0.81001904
53	MINK1	0.79651209
54	PRKCG	0.77965177
55	PLK4	0.75367670
56	WEE1	0.74829997
57	PRKCQ	0.72833992
58	DYRK3	0.72827692
59	STK3	0.69313045
60	PLK2	0.68098942
61	NLK	0.66979549
62	VRK1	0.61929315
63	PKN1	0.60507956
64	MAP2K4	0.59327270
65	DYRK1A	0.56994071
66	FGFR2	0.52833581
67	DAPK2	0.52757015
68	FER	0.52671017
69	SGK494	0.51755830
70	SGK223	0.51755830
71	MKNK1	0.51720850
72	CAMK2A	0.50623866
73	CSNK1A1	0.49526052
74	MAP2K6	0.47051468
75	IKBKB	0.46552471
76	ATM	0.45806322
77	CSNK1D	0.45155535
78	PRKG1	0.43752274
79	SGK1	0.43734134
80	IRAK1	0.43590506
81	PRKACA	0.43027172
82	OBSCN	0.42671428
83	CDK3	0.41622416
84	ITK	0.41525977
85	PRKAA1	0.39242379
86	ROCK1	0.38776135
87	ATR	0.36745886
88	NEK2	0.35044705
89	CAMK1	0.34570218
90	CAMK4	0.34547353
91	CDK5	0.33986010
92	ERBB2	0.32775321
93	PRKCI	0.32182031
94	BRD4	0.31783723
95	RPS6KA5	0.31177096
96	MAP3K7	0.31167145
97	CHUK	0.31145045
98	GRK7	0.30409450
99	PRKACB	0.30295127
100	PTK2B	0.29817709

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.26707335
2	Phototransduction_Homo sapiens_hsa04744	2.78405656
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.34753494
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30488859
5	Taste transduction_Homo sapiens_hsa04742	2.30108618
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.17564874
7	Butanoate metabolism_Homo sapiens_hsa00650	2.13478825
8	Olfactory transduction_Homo sapiens_hsa04740	2.06628262
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.06314737
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.87497834
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83222632
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80172719
13	Homologous recombination_Homo sapiens_hsa03440	1.79564540
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.74323629
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.73643023
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.73049864
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.71620419
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.63469033
19	Morphine addiction_Homo sapiens_hsa05032	1.62463172
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.60357997
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.57606600
22	Circadian entrainment_Homo sapiens_hsa04713	1.56374590
23	Circadian rhythm_Homo sapiens_hsa04710	1.39091656
24	Salivary secretion_Homo sapiens_hsa04970	1.38921849
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.37235136
26	Dopaminergic synapse_Homo sapiens_hsa04728	1.35735407
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.33641551
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.33550567
29	ABC transporters_Homo sapiens_hsa02010	1.33447869
30	Basal transcription factors_Homo sapiens_hsa03022	1.33090928
31	GABAergic synapse_Homo sapiens_hsa04727	1.32873963
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.30756853
33	Amphetamine addiction_Homo sapiens_hsa05031	1.28000067
34	Regulation of autophagy_Homo sapiens_hsa04140	1.26429942
35	Insulin secretion_Homo sapiens_hsa04911	1.17481371
36	Caffeine metabolism_Homo sapiens_hsa00232	1.16306306
37	RNA polymerase_Homo sapiens_hsa03020	1.15860010
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.15629166
39	Cocaine addiction_Homo sapiens_hsa05030	1.08157948
40	Protein export_Homo sapiens_hsa03060	1.05960571
41	Serotonergic synapse_Homo sapiens_hsa04726	1.05879319
42	Propanoate metabolism_Homo sapiens_hsa00640	1.05614396
43	Long-term depression_Homo sapiens_hsa04730	1.05163087
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.03896947
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.99629962
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99082750
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96139552
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.95834098
49	Axon guidance_Homo sapiens_hsa04360	0.93835476
50	Renin secretion_Homo sapiens_hsa04924	0.92731890
51	RNA degradation_Homo sapiens_hsa03018	0.90393096
52	Pancreatic secretion_Homo sapiens_hsa04972	0.90351480
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87279222
54	cAMP signaling pathway_Homo sapiens_hsa04024	0.84363955
55	Retinol metabolism_Homo sapiens_hsa00830	0.84290827
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.84274326
57	Cholinergic synapse_Homo sapiens_hsa04725	0.83780138
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83085401
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82379421
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82165449
61	Peroxisome_Homo sapiens_hsa04146	0.81832664
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77988449
63	Gastric acid secretion_Homo sapiens_hsa04971	0.74206324
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.73851967
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72861775
66	Oxidative phosphorylation_Homo sapiens_hsa00190	0.71000377
67	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.66657466
68	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.65572870
69	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65338711
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64885568
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.64702819
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62790798
73	Lysine degradation_Homo sapiens_hsa00310	0.62342065
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62247328
75	Asthma_Homo sapiens_hsa05310	0.60613074
76	Alcoholism_Homo sapiens_hsa05034	0.57690030
77	Purine metabolism_Homo sapiens_hsa00230	0.56987178
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56735563
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55026427
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.53952744
81	Parkinsons disease_Homo sapiens_hsa05012	0.48487010
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.45887780
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.44691795
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42886789
85	Huntingtons disease_Homo sapiens_hsa05016	0.40966390
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.40934636
87	Primary immunodeficiency_Homo sapiens_hsa05340	0.39270417
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.39117767
89	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.38497221
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.37606920
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.36964534
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36677725
93	Ras signaling pathway_Homo sapiens_hsa04014	0.36069975
94	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.35611664
95	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.35217188
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34815335
97	Alzheimers disease_Homo sapiens_hsa05010	0.31706418
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.31006518
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30581489
100	Oocyte meiosis_Homo sapiens_hsa04114	0.30434067

ANKRD36C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »