ANKRD39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)7.35698542
2muscle filament sliding (GO:0030049)7.35698542
3sarcoplasmic reticulum calcium ion transport (GO:0070296)6.73874296
4regulation of skeletal muscle contraction (GO:0014819)6.57972948
5skeletal muscle contraction (GO:0003009)6.04163782
6actin-mediated cell contraction (GO:0070252)5.86632327
7regulation of relaxation of muscle (GO:1901077)5.52741346
8negative regulation of execution phase of apoptosis (GO:1900118)5.32928873
9fat-soluble vitamin biosynthetic process (GO:0042362)5.25840974
10central nervous system myelination (GO:0022010)5.06902621
11axon ensheathment in central nervous system (GO:0032291)5.06902621
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.46616617
13creatine metabolic process (GO:0006600)4.38594290
14response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.37363836
15response to muscle activity (GO:0014850)4.31502467
16striated muscle contraction (GO:0006941)4.28059321
17electron transport chain (GO:0022900)4.27124007
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.23968891
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22224660
20regulation of glucokinase activity (GO:0033131)4.17525735
21regulation of hexokinase activity (GO:1903299)4.17525735
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.16998453
23mitochondrial respiratory chain complex I assembly (GO:0032981)4.16998453
24NADH dehydrogenase complex assembly (GO:0010257)4.16998453
25mitochondrial respiratory chain complex assembly (GO:0033108)4.13757510
26sequestering of actin monomers (GO:0042989)4.01994540
27positive thymic T cell selection (GO:0045059)3.99955875
28ubiquinone biosynthetic process (GO:0006744)3.98914466
29skeletal muscle fiber development (GO:0048741)3.98342624
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95296885
31actin filament-based movement (GO:0030048)3.91686684
32myotube cell development (GO:0014904)3.91169977
33myofibril assembly (GO:0030239)3.83325690
34GPI anchor biosynthetic process (GO:0006506)3.79605763
35sarcomere organization (GO:0045214)3.76959046
36preassembly of GPI anchor in ER membrane (GO:0016254)3.76372894
37ATP synthesis coupled proton transport (GO:0015986)3.72594831
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72594831
39oxidative phosphorylation (GO:0006119)3.70540970
40positive T cell selection (GO:0043368)3.69801618
41long-chain fatty acid biosynthetic process (GO:0042759)3.66816465
42glucan biosynthetic process (GO:0009250)3.59040289
43glycogen biosynthetic process (GO:0005978)3.59040289
44developmental pigmentation (GO:0048066)3.58981440
45ubiquinone metabolic process (GO:0006743)3.56993626
46response to inactivity (GO:0014854)3.54149619
47glycogen catabolic process (GO:0005980)3.52972761
48mesenchymal cell differentiation involved in kidney development (GO:0072161)3.52889312
49mesenchymal cell differentiation involved in renal system development (GO:2001012)3.52889312
50regulation of cell communication by electrical coupling (GO:0010649)3.48462573
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.47503025
52tricarboxylic acid cycle (GO:0006099)3.42831491
53GPI anchor metabolic process (GO:0006505)3.40419619
54regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.40118283
55fructose metabolic process (GO:0006000)3.36991525
56positive regulation of protein homodimerization activity (GO:0090073)3.36536339
57C-terminal protein lipidation (GO:0006501)3.36224406
58muscle contraction (GO:0006936)3.35745946
59muscle fiber development (GO:0048747)3.34666915
60purine nucleotide salvage (GO:0032261)3.32483977
61regulation of mitochondrial translation (GO:0070129)3.32255552
62DNA damage response, detection of DNA damage (GO:0042769)3.31135972
63neuronal action potential propagation (GO:0019227)3.29316773
64glucan catabolic process (GO:0009251)3.18377760
65gluconeogenesis (GO:0006094)3.17288917
66modulation by virus of host process (GO:0019054)3.15018694
67DNA deamination (GO:0045006)3.13103676
68succinate metabolic process (GO:0006105)3.12556310
69quinone biosynthetic process (GO:1901663)3.12531248
70mannosylation (GO:0097502)3.11478901
71peptidyl-histidine modification (GO:0018202)3.10696653
72GTP biosynthetic process (GO:0006183)3.08889550
73negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.08169087
74superoxide anion generation (GO:0042554)3.07743213
75branched-chain amino acid catabolic process (GO:0009083)3.06240576
76respiratory chain complex IV assembly (GO:0008535)3.04592355
77proteasome assembly (GO:0043248)3.04085290
78negative regulation of calcium ion transmembrane transport (GO:1903170)3.03785561
79negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.03785561
80NADH metabolic process (GO:0006734)3.00983582
81positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.99788229
82skeletal muscle adaptation (GO:0043501)2.98133961
83cellular polysaccharide catabolic process (GO:0044247)2.97803032
84muscle system process (GO:0003012)2.97053455
85inner mitochondrial membrane organization (GO:0007007)2.96772494
86positive regulation of uterine smooth muscle contraction (GO:0070474)2.96099605
87C-terminal protein amino acid modification (GO:0018410)2.94736232
88viral genome replication (GO:0019079)2.93850237
89AMP metabolic process (GO:0046033)2.90279588
90limb bud formation (GO:0060174)2.89361447
91IMP metabolic process (GO:0046040)2.86795586
92neuromuscular synaptic transmission (GO:0007274)2.83728223
93cellular ketone body metabolic process (GO:0046950)2.83318185
94cullin deneddylation (GO:0010388)2.82646469
95nucleotide transmembrane transport (GO:1901679)2.82459017
96hexose biosynthetic process (GO:0019319)2.82124646
97plasma membrane repair (GO:0001778)2.80468748
98viral protein processing (GO:0019082)2.80234109
99skeletal muscle tissue development (GO:0007519)2.79277670
100regulation of actin filament-based movement (GO:1903115)2.78312471
101inositol phosphate catabolic process (GO:0071545)2.77212090
102aerobic respiration (GO:0009060)2.74726145
1032-oxoglutarate metabolic process (GO:0006103)2.73445286
104ectoderm development (GO:0007398)2.73079706
105chaperone-mediated protein transport (GO:0072321)2.72357764
106ATP biosynthetic process (GO:0006754)2.72290442
107actomyosin structure organization (GO:0031032)2.71635566
108adenosine metabolic process (GO:0046085)2.70836647
109interferon-gamma production (GO:0032609)2.70684095
110epithelial cilium movement (GO:0003351)2.70075627
111muscle cell cellular homeostasis (GO:0046716)2.69875839
112ketone body metabolic process (GO:1902224)2.68859624
113cardiac muscle contraction (GO:0060048)2.68671446
114muscle organ morphogenesis (GO:0048644)2.68239993
115valine metabolic process (GO:0006573)2.68218268
116amyloid precursor protein catabolic process (GO:0042987)2.68072029
117branched-chain amino acid metabolic process (GO:0009081)2.67462341
118forebrain neuron differentiation (GO:0021879)2.67226027
119hydrogen ion transmembrane transport (GO:1902600)2.66385584
120polysaccharide catabolic process (GO:0000272)2.65933916
121regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64960888
122behavioral response to nicotine (GO:0035095)2.64954129
123DNA ligation (GO:0006266)2.64584145
124purine-containing compound salvage (GO:0043101)2.61593178
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61350543
126protein deneddylation (GO:0000338)2.61042812
127water-soluble vitamin biosynthetic process (GO:0042364)2.60767644
128heart process (GO:0003015)2.59480036
129heart contraction (GO:0060047)2.59480036
130oxaloacetate metabolic process (GO:0006107)2.58773345
131glycogen metabolic process (GO:0005977)2.58290045
132presynaptic membrane assembly (GO:0097105)2.57956186
133dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.56598828
134regulation of pigment cell differentiation (GO:0050932)2.55608571
135regulation of execution phase of apoptosis (GO:1900117)2.53675833
136G-protein coupled receptor internalization (GO:0002031)2.53636010
137cytochrome complex assembly (GO:0017004)2.53215917
138keratinocyte development (GO:0003334)2.52998914
139regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52986897
140cerebral cortex radially oriented cell migration (GO:0021799)2.51973932
141negative regulation of myoblast differentiation (GO:0045662)2.50435972
142ribosomal small subunit biogenesis (GO:0042274)2.48957200
143glycolipid biosynthetic process (GO:0009247)2.47571644
144mast cell activation (GO:0045576)2.47541042
145glycosphingolipid catabolic process (GO:0046479)2.47204309
146ceramide catabolic process (GO:0046514)2.46310460
147presynaptic membrane organization (GO:0097090)2.45173113
148cell differentiation involved in metanephros development (GO:0072202)2.41574389
149neuron fate determination (GO:0048664)2.39994065
150centriole assembly (GO:0098534)2.39887132
151response to redox state (GO:0051775)2.39618491
152DNA integration (GO:0015074)2.38573419
153UTP biosynthetic process (GO:0006228)2.35403310
154negative regulation of leukocyte chemotaxis (GO:0002689)2.35279658
155spermatid nucleus differentiation (GO:0007289)2.33925483
156lymphoid progenitor cell differentiation (GO:0002320)2.31993287
157omega-hydroxylase P450 pathway (GO:0097267)2.30143395
158regulation of oxidative phosphorylation (GO:0002082)2.29271886
159glycolipid catabolic process (GO:0019377)2.29218590
160CTP biosynthetic process (GO:0006241)2.29157056
161CTP metabolic process (GO:0046036)2.29157056
162oligodendrocyte differentiation (GO:0048709)2.28240291
163facial nerve structural organization (GO:0021612)2.27712071
164membrane protein ectodomain proteolysis (GO:0006509)2.25204218
165negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.25048981
166regulation of catecholamine metabolic process (GO:0042069)2.24814608
167regulation of dopamine metabolic process (GO:0042053)2.24814608
168vitamin biosynthetic process (GO:0009110)2.22607943
169guanosine-containing compound biosynthetic process (GO:1901070)2.22069419
170transcription elongation from RNA polymerase III promoter (GO:0006385)2.21916481
171termination of RNA polymerase III transcription (GO:0006386)2.21916481
172negative regulation of calcium ion transport into cytosol (GO:0010523)2.21232039
173negative regulation of protein localization to cell surface (GO:2000009)2.19465575
174amyloid precursor protein metabolic process (GO:0042982)2.19273449
175regulation of T cell migration (GO:2000404)2.19241614
176positive regulation of cellular amine metabolic process (GO:0033240)2.18657749
177regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.18484619
178cilium movement (GO:0003341)2.18367109
179negative regulation of chemokine production (GO:0032682)2.18115565
180protein complex biogenesis (GO:0070271)2.17605344
181regulation of platelet aggregation (GO:0090330)2.16210762
182deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.15931653
183deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.15485382
184negative regulation of cAMP-mediated signaling (GO:0043951)2.15233548
185negative regulation of transcription by competitive promoter binding (GO:0010944)2.14144613
186ribosomal small subunit assembly (GO:0000028)2.12937410
187regulation of timing of cell differentiation (GO:0048505)2.12087969
188lipoxygenase pathway (GO:0019372)2.11004075
189natural killer cell activation involved in immune response (GO:0002323)2.10230047
190regulation of uterine smooth muscle contraction (GO:0070472)2.09851728
191protein heterotetramerization (GO:0051290)2.09348998
192protein neddylation (GO:0045116)2.08753619
193respiratory electron transport chain (GO:0022904)2.08322893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.06103518
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.28614727
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.38202827
4GBX2_23144817_ChIP-Seq_PC3_Human3.15755981
5EZH2_22144423_ChIP-Seq_EOC_Human3.13596436
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90181038
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.82332780
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.72877608
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.45575840
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37766543
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.36549581
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.29936744
13ZNF274_21170338_ChIP-Seq_K562_Hela2.24266326
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13183775
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12452685
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11413069
17* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.07217389
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05960284
19* VDR_23849224_ChIP-Seq_CD4+_Human2.04185419
20* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02614677
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.01328572
22IRF1_19129219_ChIP-ChIP_H3396_Human1.99760043
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.97050918
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97019808
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89498799
26TAF15_26573619_Chip-Seq_HEK293_Human1.88651287
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84073236
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78228093
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76941912
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75636081
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.72986089
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71432108
33RNF2_27304074_Chip-Seq_NSC_Mouse1.70639536
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70253171
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69617759
36* FLI1_27457419_Chip-Seq_LIVER_Mouse1.68315659
37* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64167187
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62292471
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62163458
40* NFE2_27457419_Chip-Seq_LIVER_Mouse1.61123337
41STAT3_18555785_Chip-Seq_ESCs_Mouse1.60938601
42SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57632086
43VDR_22108803_ChIP-Seq_LS180_Human1.56929806
44GABP_19822575_ChIP-Seq_HepG2_Human1.54497196
45* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.53900450
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52800351
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52770234
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.52271380
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.51643888
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51296134
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.50739514
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50271998
53* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50006598
54DCP1A_22483619_ChIP-Seq_HELA_Human1.48924373
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.48803625
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.48673729
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48637966
58* P300_18555785_Chip-Seq_ESCs_Mouse1.48634029
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.48269712
60* P53_22387025_ChIP-Seq_ESCs_Mouse1.47727456
61* NMYC_18555785_Chip-Seq_ESCs_Mouse1.47222089
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46963371
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.46830740
64ER_23166858_ChIP-Seq_MCF-7_Human1.45784455
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45235019
66TP53_22573176_ChIP-Seq_HFKS_Human1.44546386
67* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43699754
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42739473
69MYC_18940864_ChIP-ChIP_HL60_Human1.42347637
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41350244
71ELK1_19687146_ChIP-ChIP_HELA_Human1.40057098
72* EZH2_27294783_Chip-Seq_NPCs_Mouse1.39289553
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.39023619
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.38387170
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38141121
76* ZFX_18555785_Chip-Seq_ESCs_Mouse1.37809207
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37591022
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37088791
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37004854
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35075963
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34767527
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34734643
83MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.34624361
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33949553
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33673029
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.33204248
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32955094
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30731386
89* SOX2_18555785_Chip-Seq_ESCs_Mouse1.30399222
90* OCT4_18555785_Chip-Seq_ESCs_Mouse1.30188939
91* KLF4_18555785_Chip-Seq_ESCs_Mouse1.27041309
92HTT_18923047_ChIP-ChIP_STHdh_Human1.26443943
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26202569
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23112576
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.22908404
96IGF1R_20145208_ChIP-Seq_DFB_Human1.22122796
97* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21773923
98* PU1_27457419_Chip-Seq_LIVER_Mouse1.20315913
99* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19919027
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19899349
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19862840
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19387535
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19387535
104P300_19829295_ChIP-Seq_ESCs_Human1.18902893
105CTCF_18555785_Chip-Seq_ESCs_Mouse1.17905669
106* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17355961
107NANOG_19829295_ChIP-Seq_ESCs_Human1.16593089
108SOX2_19829295_ChIP-Seq_ESCs_Human1.16593089
109CBP_20019798_ChIP-Seq_JUKART_Human1.15043673
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15043673
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13715801
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.13650236
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13262049
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12786404
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11009608
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.10883552
117KDM5A_27292631_Chip-Seq_BREAST_Human1.10648827
118EWS_26573619_Chip-Seq_HEK293_Human1.08499398
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08042842
120KDM2B_26808549_Chip-Seq_REH_Human1.06528000
121MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05953337
122EST1_17652178_ChIP-ChIP_JURKAT_Human1.05191917
123NCOR_22424771_ChIP-Seq_293T_Human1.04891002
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03610011
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.03547661
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03385721
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02386414
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02201304
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01993983
130OCT4_20526341_ChIP-Seq_ESCs_Human1.01856603
131RNF2_27304074_Chip-Seq_ESCs_Mouse1.01771987
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01717169
133KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01706400
134PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01009281
135STAT1_20625510_ChIP-Seq_HELA_Human1.00082797
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99568002
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99289955
138SALL1_21062744_ChIP-ChIP_HESCs_Human0.98207206
139GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98038212
140* CRX_20693478_ChIP-Seq_RETINA_Mouse0.97584025
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97515790
142* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96372907
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94819210
144FUS_26573619_Chip-Seq_HEK293_Human0.94765058
145FOXP3_21729870_ChIP-Seq_TREG_Human0.94110906
146FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92901514
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92766346
148GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91551868
149E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91269189
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90865485
151SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90445242
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89184427
153NANOG_20526341_ChIP-Seq_ESCs_Human0.88820211
154MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88429654
155CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87429271
156PHF8_20622853_ChIP-Seq_HELA_Human0.87411313
157* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86552552
158REST_18959480_ChIP-ChIP_MESCs_Mouse0.86183868
159P53_21459846_ChIP-Seq_SAOS-2_Human0.85638842
160HOXB7_26014856_ChIP-Seq_BT474_Human0.84448559
161TTF2_22483619_ChIP-Seq_HELA_Human0.83655696
162CIITA_25753668_ChIP-Seq_RAJI_Human0.81348714
163CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81095469
164AR_20517297_ChIP-Seq_VCAP_Human0.81061839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.92104176
2MP0000749_muscle_degeneration4.36197768
3MP0001188_hyperpigmentation4.10139228
4MP0000751_myopathy3.88879579
5MP0006292_abnormal_olfactory_placode3.42373265
6MP0002102_abnormal_ear_morphology3.08715813
7MP0003136_yellow_coat_color2.98375870
8MP0009379_abnormal_foot_pigmentation2.96335239
9MP0004036_abnormal_muscle_relaxation2.93304203
10MP0006036_abnormal_mitochondrial_physio2.93152790
11MP0002837_dystrophic_cardiac_calcinosis2.88423366
12MP0002106_abnormal_muscle_physiology2.81117795
13MP0003938_abnormal_ear_development2.68589905
14MP0003303_peritoneal_inflammation2.66775673
15MP0004381_abnormal_hair_follicle2.59236411
16MP0000566_synostosis2.58984018
17MP0003646_muscle_fatigue2.55054566
18MP0005409_darkened_coat_color2.41929355
19MP0005369_muscle_phenotype2.35409268
20MP0000747_muscle_weakness2.33805370
21MP0000759_abnormal_skeletal_muscle2.31211502
22MP0003880_abnormal_central_pattern2.26492021
23MP0002332_abnormal_exercise_endurance2.26104919
24MP0002269_muscular_atrophy2.21409840
25MP0004087_abnormal_muscle_fiber2.18688772
26MP0005171_absent_coat_pigmentation2.14744498
27MP0005645_abnormal_hypothalamus_physiol2.12866165
28MP0005620_abnormal_muscle_contractility2.11755278
29MP0004742_abnormal_vestibular_system2.07565314
30MP0005330_cardiomyopathy2.03960685
31MP0005451_abnormal_body_composition2.03952091
32MP0004233_abnormal_muscle_weight1.90958479
33MP0001905_abnormal_dopamine_level1.90186875
34MP0008995_early_reproductive_senescence1.88917903
35MP0000015_abnormal_ear_pigmentation1.88544862
36MP0001986_abnormal_taste_sensitivity1.84126190
37MP0009278_abnormal_bone_marrow1.83659874
38MP0002822_catalepsy1.83570744
39MP0000750_abnormal_muscle_regeneration1.81708246
40MP0004130_abnormal_muscle_cell1.76167203
41MP0000778_abnormal_nervous_system1.73985980
42MP0006276_abnormal_autonomic_nervous1.69907784
43MP0003763_abnormal_thymus_physiology1.65693001
44MP0000026_abnormal_inner_ear1.64760580
45MP0004215_abnormal_myocardial_fiber1.61576411
46MP0004084_abnormal_cardiac_muscle1.58287721
47MP0004270_analgesia1.57528965
48MP0005379_endocrine/exocrine_gland_phen1.55056096
49MP0004142_abnormal_muscle_tone1.54771123
50MP0005266_abnormal_metabolism1.53824678
51MP0008877_abnormal_DNA_methylation1.52665736
52MP0002277_abnormal_respiratory_mucosa1.50392059
53MP0002638_abnormal_pupillary_reflex1.50331405
54MP0002972_abnormal_cardiac_muscle1.48917756
55MP0005174_abnormal_tail_pigmentation1.45265008
56MP0005423_abnormal_somatic_nervous1.44504261
57MP0001485_abnormal_pinna_reflex1.42948452
58MP0000049_abnormal_middle_ear1.42584530
59MP0005410_abnormal_fertilization1.42090546
60MP0002163_abnormal_gland_morphology1.41885992
61MP0000372_irregular_coat_pigmentation1.41477844
62MP0001963_abnormal_hearing_physiology1.41045094
63MP0003787_abnormal_imprinting1.40739530
64MP0005075_abnormal_melanosome_morpholog1.39832213
65MP0000920_abnormal_myelination1.38474321
66MP0002938_white_spotting1.33505546
67MP0001529_abnormal_vocalization1.31831733
68MP0006035_abnormal_mitochondrial_morpho1.31254016
69MP0001661_extended_life_span1.31154153
70MP0008058_abnormal_DNA_repair1.30783484
71MP0000013_abnormal_adipose_tissue1.24632442
72MP0003123_paternal_imprinting1.23269895
73MP0005671_abnormal_response_to1.22376794
74MP0002132_abnormal_respiratory_system1.22153419
75MP0001324_abnormal_eye_pigmentation1.20865890
76MP0003724_increased_susceptibility_to1.20792037
77MP0002933_joint_inflammation1.20450381
78MP0003806_abnormal_nucleotide_metabolis1.19698445
79MP0009046_muscle_twitch1.19307199
80MP0002148_abnormal_hypersensitivity_rea1.19282592
81MP0002108_abnormal_muscle_morphology1.17025129
82MP0005551_abnormal_eye_electrophysiolog1.14287134
83MP0005646_abnormal_pituitary_gland1.14190610
84MP0003137_abnormal_impulse_conducting1.08073685
85MP0009333_abnormal_splenocyte_physiolog1.08040293
86MP0003950_abnormal_plasma_membrane1.06878668
87MP0008789_abnormal_olfactory_epithelium1.05970748
88MP0002095_abnormal_skin_pigmentation1.05170280
89MP0006072_abnormal_retinal_apoptosis1.04929090
90MP0000538_abnormal_urinary_bladder1.04135620
91MP0001486_abnormal_startle_reflex1.03844408
92MP0009785_altered_susceptibility_to1.01879272
93MP0000631_abnormal_neuroendocrine_gland1.01105225
94MP0004484_altered_response_of0.99580829
95MP0005000_abnormal_immune_tolerance0.99075015
96MP0001286_abnormal_eye_development0.98543277
97MP0004147_increased_porphyrin_level0.97151659
98MP0005220_abnormal_exocrine_pancreas0.96685851
99MP0001502_abnormal_circadian_rhythm0.96574983
100MP0003195_calcinosis0.96412158
101MP0000858_altered_metastatic_potential0.94795543
102MP0001270_distended_abdomen0.94760266
103MP0003122_maternal_imprinting0.92955265
104MP0001984_abnormal_olfaction0.92240762
105MP0003786_premature_aging0.91843195
106MP0002272_abnormal_nervous_system0.91722756
107MP0005253_abnormal_eye_physiology0.90453023
108MP0001346_abnormal_lacrimal_gland0.89819545
109MP0008260_abnormal_autophagy0.89552522
110MP0010386_abnormal_urinary_bladder0.89013491
111MP0000613_abnormal_salivary_gland0.88232389
112MP0008872_abnormal_physiological_respon0.87584203
113MP0003121_genomic_imprinting0.86198128
114MP0002127_abnormal_cardiovascular_syste0.85698364
115MP0005332_abnormal_amino_acid0.85367587
116MP0009697_abnormal_copulation0.84961571
117MP0002735_abnormal_chemical_nociception0.84444820
118MP0002751_abnormal_autonomic_nervous0.83926038
119MP0000733_abnormal_muscle_development0.83923912
120MP0002752_abnormal_somatic_nervous0.83631963
121MP0002734_abnormal_mechanical_nocicepti0.83554751
122MP0001968_abnormal_touch/_nociception0.83038414
123MP0004043_abnormal_pH_regulation0.82480430
124MP0004133_heterotaxia0.82095121
125MP0002697_abnormal_eye_size0.81845751
126MP0001835_abnormal_antigen_presentation0.81709751
127MP0002405_respiratory_system_inflammati0.81514121
128MP0005386_behavior/neurological_phenoty0.80550281
129MP0004924_abnormal_behavior0.80550281
130MP0004885_abnormal_endolymph0.79527004
131MP0009745_abnormal_behavioral_response0.79445174
132MP0002177_abnormal_outer_ear0.79235662
133MP0002078_abnormal_glucose_homeostasis0.79152373
134MP0001664_abnormal_digestion0.79052846
135MP0005195_abnormal_posterior_eye0.77545597
136MP0001790_abnormal_immune_system0.76496429
137MP0005387_immune_system_phenotype0.76496429
138MP0008775_abnormal_heart_ventricle0.74813852
139MP0003315_abnormal_perineum_morphology0.74129523
140MP0003111_abnormal_nucleus_morphology0.73629502
141MP0002723_abnormal_immune_serum0.73482842
142MP0004085_abnormal_heartbeat0.73157480
143MP0003186_abnormal_redox_activity0.73135451
144MP0001177_atelectasis0.72761141
145MP0001727_abnormal_embryo_implantation0.72328809
146MP0003221_abnormal_cardiomyocyte_apopto0.72209852
147MP0005394_taste/olfaction_phenotype0.71636398
148MP0005499_abnormal_olfactory_system0.71636398
149MP0005025_abnormal_response_to0.71539758
150MP0002419_abnormal_innate_immunity0.71514277
151MP0001544_abnormal_cardiovascular_syste0.71327929
152MP0005385_cardiovascular_system_phenoty0.71327929
153MP0005535_abnormal_body_temperature0.70972451
154MP0002234_abnormal_pharynx_morphology0.70966630
155MP0002736_abnormal_nociception_after0.70507746
156MP0002452_abnormal_antigen_presenting0.69597213
157MP0002876_abnormal_thyroid_physiology0.69339071
158MP0001186_pigmentation_phenotype0.69079814
159MP0002420_abnormal_adaptive_immunity0.68887585
160MP0001919_abnormal_reproductive_system0.68063311
161MP0001819_abnormal_immune_cell0.67577208
162MP0005670_abnormal_white_adipose0.67146484
163MP0002067_abnormal_sensory_capabilities0.61897016
164MP0002971_abnormal_brown_adipose0.60616344
165MP0010094_abnormal_chromosome_stability0.60268704
166MP0002693_abnormal_pancreas_physiology0.57690913
167MP0004134_abnormal_chest_morphology0.56807475
168MP0002064_seizures0.56264157
169MP0010630_abnormal_cardiac_muscle0.55383887

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.93505356
2Nemaline bodies (HP:0003798)8.76232972
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.50721763
4Exercise-induced myalgia (HP:0003738)6.29226111
5Exercise-induced muscle cramps (HP:0003710)6.19935209
6Type 1 muscle fiber predominance (HP:0003803)5.61944572
7Muscle hypertrophy of the lower extremities (HP:0008968)5.37950893
8Calf muscle hypertrophy (HP:0008981)4.81010476
9Myopathic facies (HP:0002058)4.48958381
10Distal arthrogryposis (HP:0005684)4.41175792
11Myoglobinuria (HP:0002913)4.15870848
12EMG: myopathic abnormalities (HP:0003458)4.06789700
13Rhabdomyolysis (HP:0003201)4.00106913
14Gastrointestinal infarctions (HP:0005244)3.82290680
15Rimmed vacuoles (HP:0003805)3.60097839
16Abnormality of the calf musculature (HP:0001430)3.48176995
17Progressive macrocephaly (HP:0004481)3.44763280
18Acute encephalopathy (HP:0006846)3.42091704
19Parakeratosis (HP:0001036)3.39039954
20Hepatic necrosis (HP:0002605)3.30748026
21Hypochromic anemia (HP:0001931)3.30544153
22Duplicated collecting system (HP:0000081)3.26317176
23Round ear (HP:0100830)3.21595037
24Optic disc pallor (HP:0000543)3.20302844
25Ulnar deviation of the wrist (HP:0003049)3.18439224
26True hermaphroditism (HP:0010459)3.17553954
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12987078
28Muscle fiber splitting (HP:0003555)3.11686993
29Exercise intolerance (HP:0003546)3.11436271
30Neck muscle weakness (HP:0000467)3.11249616
31Hyporeflexia of lower limbs (HP:0002600)3.05301207
32Gonadal dysgenesis (HP:0000133)3.04735633
33Abnormality of the fingertips (HP:0001211)3.01456899
34Muscle stiffness (HP:0003552)2.94852985
35Abnormality of the renal collecting system (HP:0004742)2.92891659
36Myotonia (HP:0002486)2.88293088
37Type I transferrin isoform profile (HP:0003642)2.87931181
38Mitochondrial inheritance (HP:0001427)2.84627521
39Increased intramyocellular lipid droplets (HP:0012240)2.80405248
40Septo-optic dysplasia (HP:0100842)2.78752380
41Calcaneovalgus deformity (HP:0001848)2.72599576
42Absent phalangeal crease (HP:0006109)2.71676900
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67349740
44Renal Fanconi syndrome (HP:0001994)2.57707055
45Areflexia of lower limbs (HP:0002522)2.57408095
46Centrally nucleated skeletal muscle fibers (HP:0003687)2.57277497
47Frequent falls (HP:0002359)2.55397234
48Cerebral edema (HP:0002181)2.53077856
49Chromsome breakage (HP:0040012)2.52959574
50Difficulty running (HP:0009046)2.48277599
51Abnormality of the left ventricular outflow tract (HP:0011103)2.48046983
52Subaortic stenosis (HP:0001682)2.48046983
53Deformed tarsal bones (HP:0008119)2.47888088
54Reticulocytopenia (HP:0001896)2.45336885
553-Methylglutaconic aciduria (HP:0003535)2.45053983
56Pancreatic fibrosis (HP:0100732)2.44941860
57Increased muscle lipid content (HP:0009058)2.44895120
58Abnormality of secondary sexual hair (HP:0009888)2.43216252
59Abnormality of the axillary hair (HP:0100134)2.43216252
60Thyroid-stimulating hormone excess (HP:0002925)2.41665081
61Lactic acidosis (HP:0003128)2.41411584
62Recurrent abscess formation (HP:0002722)2.41167383
63Malignant hyperthermia (HP:0002047)2.36889131
64Morphological abnormality of the inner ear (HP:0011390)2.36254414
65Aplastic anemia (HP:0001915)2.32099596
66Abnormality of skeletal muscle fiber size (HP:0012084)2.31747176
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31422312
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31422312
69Pancreatic cysts (HP:0001737)2.30778743
70Severe visual impairment (HP:0001141)2.29776357
71Congenital sensorineural hearing impairment (HP:0008527)2.29753443
72Abnormal ciliary motility (HP:0012262)2.28124274
73Hypothermia (HP:0002045)2.27897036
74Nasal polyposis (HP:0100582)2.27443965
75Retinal dysplasia (HP:0007973)2.27009412
76Patchy hypopigmentation of hair (HP:0011365)2.25970002
77Respiratory failure (HP:0002878)2.25890019
78Acute necrotizing encephalopathy (HP:0006965)2.25573688
79Esophageal neoplasm (HP:0100751)2.25435926
80Neoplasm of head and neck (HP:0012288)2.25435926
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24551829
82Absent septum pellucidum (HP:0001331)2.23863613
83Progressive muscle weakness (HP:0003323)2.21727661
84Increased serum lactate (HP:0002151)2.20586952
85Abnormality of nail color (HP:0100643)2.20283578
86Optic nerve hypoplasia (HP:0000609)2.18584717
87Increased hepatocellular lipid droplets (HP:0006565)2.18339999
88Reduced antithrombin III activity (HP:0001976)2.17629121
89Abnormal finger flexion creases (HP:0006143)2.17189071
90White forelock (HP:0002211)2.15768352
91Male pseudohermaphroditism (HP:0000037)2.15056399
92Bundle branch block (HP:0011710)2.11616957
93Fetal akinesia sequence (HP:0001989)2.10934148
94Slender build (HP:0001533)2.10745651
95Conical tooth (HP:0000698)2.10066454
96Aplasia cutis congenita (HP:0001057)2.09995986
97Abnormality of the septum pellucidum (HP:0007375)2.09908687
98EMG: neuropathic changes (HP:0003445)2.09543824
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08033533
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.06434629
101Absent/shortened dynein arms (HP:0200106)2.06434629
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05709148
103Abnormal respiratory motile cilium morphology (HP:0005938)2.05139733
104Abnormal respiratory epithelium morphology (HP:0012253)2.05139733
105Recurrent bacterial skin infections (HP:0005406)2.01363109
106Generalized muscle weakness (HP:0003324)2.00262214
107Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00166309
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99446372
109Abnormal protein N-linked glycosylation (HP:0012347)1.99446372
110Abnormal protein glycosylation (HP:0012346)1.99446372
111Abnormal glycosylation (HP:0012345)1.99446372
112Sudden death (HP:0001699)1.98368234
113Hepatocellular necrosis (HP:0001404)1.95413962
114Hypoplasia of the fovea (HP:0007750)1.94581137
115Aplasia/Hypoplasia of the fovea (HP:0008060)1.94581137
116Congenital stationary night blindness (HP:0007642)1.94347664
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93424054
118Hyperinsulinemic hypoglycemia (HP:0000825)1.92322567
119Occipital encephalocele (HP:0002085)1.88468899
120Tubulointerstitial nephritis (HP:0001970)1.86804242
121Decreased central vision (HP:0007663)1.86422926
122Distal lower limb muscle weakness (HP:0009053)1.86409184
123Anencephaly (HP:0002323)1.85907793
124Large for gestational age (HP:0001520)1.84826180
125Duplication of thumb phalanx (HP:0009942)1.84327379
126Exertional dyspnea (HP:0002875)1.83565413
127Increased CSF lactate (HP:0002490)1.83209420
128Ragged-red muscle fibers (HP:0003200)1.82688843
129Abnormal hair whorl (HP:0010721)1.82376896
130Abnormal respiratory motile cilium physiology (HP:0012261)1.81923443
131Postaxial foot polydactyly (HP:0001830)1.81479842
132Abnormality of renal resorption (HP:0011038)1.81120946
133Type 2 muscle fiber atrophy (HP:0003554)1.80673423
134Ketoacidosis (HP:0001993)1.80652188
135Preaxial hand polydactyly (HP:0001177)1.79228924
136Increased corneal curvature (HP:0100692)1.78708561
137Keratoconus (HP:0000563)1.78708561
138Attenuation of retinal blood vessels (HP:0007843)1.78504038
139Pulmonary artery stenosis (HP:0004415)1.78432728
140Retrobulbar optic neuritis (HP:0100654)1.78187837
141Optic neuritis (HP:0100653)1.78187837
142Nasolacrimal duct obstruction (HP:0000579)1.77748902
143Gowers sign (HP:0003391)1.77583093
144Asymmetric septal hypertrophy (HP:0001670)1.77529192
145Fatigable weakness (HP:0003473)1.76919082
146Abnormality of the neuromuscular junction (HP:0003398)1.76919082
147Anomalous pulmonary venous return (HP:0010772)1.76262180
148Nephronophthisis (HP:0000090)1.76036770
149Dicarboxylic aciduria (HP:0003215)1.75997927
150Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75997927
151Medial flaring of the eyebrow (HP:0010747)1.75420474
152Rectal prolapse (HP:0002035)1.75139202
153Microvesicular hepatic steatosis (HP:0001414)1.74077257
154Weak cry (HP:0001612)1.73646793
155Abnormal mitochondria in muscle tissue (HP:0008316)1.72806287
156Abnormality of incisor morphology (HP:0011063)1.71824376
157Dilated cardiomyopathy (HP:0001644)1.71438008
158Upper limb muscle weakness (HP:0003484)1.70488387
159Limb dystonia (HP:0002451)1.70484102
160Partial agenesis of the corpus callosum (HP:0001338)1.69923027
161Poor speech (HP:0002465)1.69922725
162Proximal amyotrophy (HP:0007126)1.69053669
163Increased connective tissue (HP:0009025)1.68823846
164Thickened helices (HP:0000391)1.68445010
165Atelectasis (HP:0100750)1.67220444
166Esotropia (HP:0000565)1.66526881
167Paralysis (HP:0003470)1.66311336
168Methylmalonic acidemia (HP:0002912)1.66218283
169Lipid accumulation in hepatocytes (HP:0006561)1.65258300
170Cupped ear (HP:0000378)1.64971314
171Increased variability in muscle fiber diameter (HP:0003557)1.64567458
172Triphalangeal thumb (HP:0001199)1.64557465
173Broad-based gait (HP:0002136)1.62222196
174Hyperkalemia (HP:0002153)1.62038448
175Muscular dystrophy (HP:0003560)1.60233930
176Lethargy (HP:0001254)1.59736450
177Ketosis (HP:0001946)1.59331707
178Muscle fiber atrophy (HP:0100295)1.58181278
179Long clavicles (HP:0000890)1.58080153
180Hyperglycemia (HP:0003074)1.57991986
181Respiratory insufficiency due to muscle weakness (HP:0002747)1.57366867
182Neoplasm of the adrenal gland (HP:0100631)1.57109400
183Insulin-resistant diabetes mellitus (HP:0000831)1.55815121
184Hyperglycinuria (HP:0003108)1.53782589
185Bulbar palsy (HP:0001283)1.53599574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG25.40538282
2PHKG15.40538282
3TLK13.56091526
4TNIK3.35361872
5STK163.29417108
6TTN3.02881663
7CASK2.93948931
8MAP3K122.88063798
9FRK2.80668952
10PRPF4B2.66703554
11TAOK22.48010115
12CLK12.40240273
13PBK2.39190714
14NME22.37468971
15IRAK32.34041332
16IRAK42.19782652
17NME12.07895566
18MAP4K22.07127633
19TXK2.00385216
20BCKDK1.98414096
21MKNK21.98186345
22PIK3CG1.77355274
23BMPR1B1.70839304
24BLK1.68623292
25TRIM281.66674237
26NEK11.65773670
27PDK21.63764473
28SRPK11.62448857
29VRK21.57746842
30ZAK1.51223393
31MYLK1.45075847
32MAPK151.40704375
33MKNK11.37906100
34STK391.37367791
35ADRBK21.37126003
36RPS6KA51.36862878
37TEC1.36163601
38LIMK11.36069282
39VRK11.35728207
40CDK191.34269197
41MARK11.33880519
42NUAK11.33757989
43PKN11.33255195
44MAP2K41.31768157
45ERBB31.31658289
46INSRR1.23383836
47OXSR11.21330428
48NLK1.20923070
49CCNB11.19984004
50IRAK21.18733937
51MAP3K41.16090134
52TIE11.14581651
53YES11.14499056
54MAPK121.14359133
55GRK11.09707151
56MAPK131.05764316
57EIF2AK31.03274893
58PIM21.00597993
59BMPR20.99322798
60MAP3K70.97290609
61BUB10.97163132
62RPS6KA20.93914734
63RPS6KL10.90193307
64RPS6KC10.90193307
65TNK20.89603799
66IRAK10.88830120
67GRK70.88219230
68DYRK20.87678132
69MAPKAPK30.87473110
70EIF2AK20.86740418
71MAPKAPK50.84884174
72MST40.83148560
73RPS6KA60.81104427
74BRAF0.79335345
75MAP3K140.76507127
76CAMK2G0.75135469
77CSNK1G30.74095232
78PRKAA10.73959549
79WNK30.72932673
80NEK60.72766736
81PRKAA20.71914412
82UHMK10.70861685
83BRSK20.69234121
84HIPK20.68693913
85BTK0.67378488
86CSNK1A1L0.67214801
87DAPK30.67028420
88TAOK30.66916651
89MAP2K70.66552408
90IKBKB0.66265164
91ITK0.65064278
92FES0.63696052
93CDK30.63028545
94LYN0.62295326
95CAMK2B0.61401636
96DAPK20.59732414
97KIT0.58843055
98MAP2K30.58768930
99CAMK2A0.57423035
100ROCK20.55809298
101EIF2AK10.54949844
102CSNK1G10.54538904
103PRKG10.53930039
104CAMK10.52946035
105DYRK30.52146547
106PAK30.51503073
107PLK10.51402836
108MUSK0.50510255
109BCR0.48815385
110KDR0.48543528
111PRKACA0.48327201
112CDC70.47381073
113CDK80.46374499
114PRKD20.46221354
115PLK30.45995485
116MAP3K110.45992192
117MAP2K60.45339630
118PRKCE0.44967708
119LCK0.44884886
120CAMK40.43532707
121AKT20.43420231
122PRKCQ0.43195482
123MARK30.41564688
124IKBKE0.41096643
125CAMK2D0.40694384
126DYRK1A0.40141617
127CSNK1A10.39666603
128WNK10.39300343
129STK40.38746023
130PRKCG0.38674091
131ROCK10.38429421
132OBSCN0.38061503
133PLK40.35677795
134AKT30.35439898
135PINK10.34297282
136FGFR20.34296016
137SYK0.34199435
138CDC42BPA0.34071422
139STK110.33366928
140SGK4940.33324083
141SGK2230.33324083
142WEE10.33322171
143TESK20.32791333
144TRPM70.31842254
145MAP4K10.31708758
146CSNK1G20.30974204
147BRSK10.30788886
148DAPK10.29640951
149CSNK2A20.28905884
150PRKACB0.28754418
151ABL20.26016732
152DMPK0.25971474
153PRKCI0.23576906
154ATR0.23532254
155PLK20.22892303
156SGK10.21876523
157MAP2K10.21508114
158RPS6KA30.19828430
159PRKDC0.18706751
160CSNK2A10.18619199
161PRKCA0.18276201

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.96934344
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.93617760
3Ether lipid metabolism_Homo sapiens_hsa005652.80973443
4Protein export_Homo sapiens_hsa030602.75568714
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.75068586
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.74157301
7Ribosome_Homo sapiens_hsa030102.58411571
8Parkinsons disease_Homo sapiens_hsa050122.52156105
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.45298737
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10079713
11Propanoate metabolism_Homo sapiens_hsa006402.09816759
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01762263
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98202112
14Sphingolipid metabolism_Homo sapiens_hsa006001.97910925
15Alzheimers disease_Homo sapiens_hsa050101.92151759
16Butanoate metabolism_Homo sapiens_hsa006501.90701410
17RNA polymerase_Homo sapiens_hsa030201.90258926
18Circadian rhythm_Homo sapiens_hsa047101.88255384
19Huntingtons disease_Homo sapiens_hsa050161.75812754
20Fanconi anemia pathway_Homo sapiens_hsa034601.74272050
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72428827
22Homologous recombination_Homo sapiens_hsa034401.71547175
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67012834
24Other glycan degradation_Homo sapiens_hsa005111.66085521
25DNA replication_Homo sapiens_hsa030301.65801218
26Pyruvate metabolism_Homo sapiens_hsa006201.64369943
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63633405
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63353346
29Primary immunodeficiency_Homo sapiens_hsa053401.61332168
30Nucleotide excision repair_Homo sapiens_hsa034201.56589115
31Basal transcription factors_Homo sapiens_hsa030221.56108444
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51799376
33Autoimmune thyroid disease_Homo sapiens_hsa053201.51775014
34Base excision repair_Homo sapiens_hsa034101.50231560
35Carbon metabolism_Homo sapiens_hsa012001.48533257
36Mismatch repair_Homo sapiens_hsa034301.47895551
37Graft-versus-host disease_Homo sapiens_hsa053321.47258063
38Steroid biosynthesis_Homo sapiens_hsa001001.43404518
39Arachidonic acid metabolism_Homo sapiens_hsa005901.39407619
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35103135
41Pyrimidine metabolism_Homo sapiens_hsa002401.26665483
42Allograft rejection_Homo sapiens_hsa053301.26077345
43Phototransduction_Homo sapiens_hsa047441.25608269
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25041812
45Arginine and proline metabolism_Homo sapiens_hsa003301.24316181
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22814767
47Dilated cardiomyopathy_Homo sapiens_hsa054141.21787906
48Serotonergic synapse_Homo sapiens_hsa047261.21420932
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20393202
50Glucagon signaling pathway_Homo sapiens_hsa049221.20363430
51Non-homologous end-joining_Homo sapiens_hsa034501.18838883
52Fructose and mannose metabolism_Homo sapiens_hsa000511.17970682
53Fatty acid elongation_Homo sapiens_hsa000621.15768404
54Hematopoietic cell lineage_Homo sapiens_hsa046401.13787763
55Peroxisome_Homo sapiens_hsa041461.13717852
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.12432410
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.11123748
58Fatty acid degradation_Homo sapiens_hsa000711.10917399
59Nitrogen metabolism_Homo sapiens_hsa009101.06724201
60Fatty acid metabolism_Homo sapiens_hsa012121.05314574
61Proteasome_Homo sapiens_hsa030501.05027566
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03970733
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01376709
64Pentose phosphate pathway_Homo sapiens_hsa000301.00885602
65Cardiac muscle contraction_Homo sapiens_hsa042601.00363357
66Folate biosynthesis_Homo sapiens_hsa007900.99753152
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99100689
68Morphine addiction_Homo sapiens_hsa050320.98891179
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98811611
70Spliceosome_Homo sapiens_hsa030400.96553295
71Tryptophan metabolism_Homo sapiens_hsa003800.96103828
72Rheumatoid arthritis_Homo sapiens_hsa053230.94993906
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94771018
74Purine metabolism_Homo sapiens_hsa002300.94604399
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91686804
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90986807
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89380381
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89139742
79Calcium signaling pathway_Homo sapiens_hsa040200.88442198
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85981537
81Linoleic acid metabolism_Homo sapiens_hsa005910.85161574
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83671423
83Insulin secretion_Homo sapiens_hsa049110.83402471
84Arginine biosynthesis_Homo sapiens_hsa002200.83326869
85Biosynthesis of amino acids_Homo sapiens_hsa012300.80917118
86Regulation of autophagy_Homo sapiens_hsa041400.80871322
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80864322
88Asthma_Homo sapiens_hsa053100.80166008
89Nicotine addiction_Homo sapiens_hsa050330.78470470
90Notch signaling pathway_Homo sapiens_hsa043300.77732170
91beta-Alanine metabolism_Homo sapiens_hsa004100.74153637
92Glutamatergic synapse_Homo sapiens_hsa047240.74115563
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73645801
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70848646
95Sulfur relay system_Homo sapiens_hsa041220.70316957
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.69865075
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68423491
98Measles_Homo sapiens_hsa051620.65717260
99Oxytocin signaling pathway_Homo sapiens_hsa049210.65116330
100Taste transduction_Homo sapiens_hsa047420.64769489
101Glutathione metabolism_Homo sapiens_hsa004800.64721398
102RNA degradation_Homo sapiens_hsa030180.64081463
103Malaria_Homo sapiens_hsa051440.63660435
104GABAergic synapse_Homo sapiens_hsa047270.61887804
105Basal cell carcinoma_Homo sapiens_hsa052170.61548448
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.61520280
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60674014
108Insulin signaling pathway_Homo sapiens_hsa049100.59659577
109RNA transport_Homo sapiens_hsa030130.57876173
110Vitamin B6 metabolism_Homo sapiens_hsa007500.57813923
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55930328
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55848095
113Olfactory transduction_Homo sapiens_hsa047400.55375874
114Type I diabetes mellitus_Homo sapiens_hsa049400.54988259
115Oocyte meiosis_Homo sapiens_hsa041140.54846545
116Hedgehog signaling pathway_Homo sapiens_hsa043400.54805514
117Axon guidance_Homo sapiens_hsa043600.54588375
118Collecting duct acid secretion_Homo sapiens_hsa049660.54425969
119Insulin resistance_Homo sapiens_hsa049310.52621324
120Metabolic pathways_Homo sapiens_hsa011000.51815943
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49973009
122Cell cycle_Homo sapiens_hsa041100.47470457
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47068412
124AMPK signaling pathway_Homo sapiens_hsa041520.46474055
125One carbon pool by folate_Homo sapiens_hsa006700.45740159
126Alcoholism_Homo sapiens_hsa050340.43403466
127Circadian entrainment_Homo sapiens_hsa047130.43255493
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42262371
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.41648017
130Starch and sucrose metabolism_Homo sapiens_hsa005000.41191963
131Ras signaling pathway_Homo sapiens_hsa040140.41069106
132T cell receptor signaling pathway_Homo sapiens_hsa046600.40985286
133Chemokine signaling pathway_Homo sapiens_hsa040620.40645063
134African trypanosomiasis_Homo sapiens_hsa051430.40504681
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.37062872
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36971100
137Cholinergic synapse_Homo sapiens_hsa047250.36906658
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36748511
139Herpes simplex infection_Homo sapiens_hsa051680.36015963
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35829914
141Phagosome_Homo sapiens_hsa041450.33970162
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32568499
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.31997937
144Synaptic vesicle cycle_Homo sapiens_hsa047210.31734936
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31523089
146Leishmaniasis_Homo sapiens_hsa051400.31473631
147Phenylalanine metabolism_Homo sapiens_hsa003600.30203699
148Pathways in cancer_Homo sapiens_hsa052000.28789480
149Amphetamine addiction_Homo sapiens_hsa050310.28341738
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27681512
151Dopaminergic synapse_Homo sapiens_hsa047280.27287137
152Selenocompound metabolism_Homo sapiens_hsa004500.26748495
153Long-term depression_Homo sapiens_hsa047300.26743881
154Wnt signaling pathway_Homo sapiens_hsa043100.26209992
155Sulfur metabolism_Homo sapiens_hsa009200.25492008
156Primary bile acid biosynthesis_Homo sapiens_hsa001200.25445238
157Systemic lupus erythematosus_Homo sapiens_hsa053220.25144914
158Lysine degradation_Homo sapiens_hsa003100.24921323
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24772126

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