ANKRD40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.37957355
2plasma membrane repair (GO:0001778)4.07606046
3negative regulation of potassium ion transmembrane transport (GO:1901380)4.07258017
4cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.95473317
5regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.78002800
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.73281825
7positive regulation of protein autophosphorylation (GO:0031954)3.63646821
8sarcomere organization (GO:0045214)3.62025012
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.57308782
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.56437233
11potassium ion import (GO:0010107)3.55441500
12cardiac myofibril assembly (GO:0055003)3.53229028
13cell communication by electrical coupling (GO:0010644)3.43061519
14sarcoplasmic reticulum calcium ion transport (GO:0070296)3.41603698
15sodium ion export (GO:0071436)3.40552291
16regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.36896033
17myofibril assembly (GO:0030239)3.36675668
18protein K6-linked ubiquitination (GO:0085020)3.34616954
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32259564
20lactate metabolic process (GO:0006089)3.32040672
21respiratory chain complex IV assembly (GO:0008535)3.29030808
22creatine metabolic process (GO:0006600)3.26939984
23regulation of glucokinase activity (GO:0033131)3.26568630
24regulation of hexokinase activity (GO:1903299)3.26568630
25regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.25921940
26cellular potassium ion homeostasis (GO:0030007)3.25690692
27regulation of membrane repolarization (GO:0060306)3.23201231
28cardiac muscle contraction (GO:0060048)3.23105730
29muscle filament sliding (GO:0030049)3.20756481
30actin-myosin filament sliding (GO:0033275)3.20756481
31cell communication involved in cardiac conduction (GO:0086065)3.15803042
32regulation of cell communication by electrical coupling (GO:0010649)3.15506444
33regulation of skeletal muscle contraction (GO:0014819)3.14635038
34regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.12214597
35carnitine shuttle (GO:0006853)3.11535523
36synaptic vesicle maturation (GO:0016188)3.05598840
37regulation of actin filament-based movement (GO:1903115)3.02899371
38inositol phosphate catabolic process (GO:0071545)3.01788088
39positive regulation of glycolytic process (GO:0045821)3.00118363
40proteasome assembly (GO:0043248)2.95886584
41negative regulation of protein localization to cell surface (GO:2000009)2.91759939
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.89793477
43regulation of Rac protein signal transduction (GO:0035020)2.87445995
44regulation of sulfur metabolic process (GO:0042762)2.86909643
45fatty acid transmembrane transport (GO:1902001)2.86712541
46tricarboxylic acid cycle (GO:0006099)2.84934434
47locomotory exploration behavior (GO:0035641)2.84793403
48activation of protein kinase A activity (GO:0034199)2.82648711
49DNA double-strand break processing (GO:0000729)2.82328735
50regulation of calcium ion transmembrane transport (GO:1903169)2.81193489
51regulation of calcium ion transmembrane transporter activity (GO:1901019)2.81193489
52positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.77821113
53striated muscle contraction (GO:0006941)2.74593399
54cytochrome complex assembly (GO:0017004)2.72244675
55neuronal action potential propagation (GO:0019227)2.71750624
56protein localization to endosome (GO:0036010)2.71074821
57relaxation of cardiac muscle (GO:0055119)2.70380094
58actomyosin structure organization (GO:0031032)2.69446598
59actin-mediated cell contraction (GO:0070252)2.68844843
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.67069362
61regulation of synapse structural plasticity (GO:0051823)2.65421509
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64464061
63mitotic sister chromatid cohesion (GO:0007064)2.63578005
64regulation of acyl-CoA biosynthetic process (GO:0050812)2.63275561
65ventricular cardiac muscle cell action potential (GO:0086005)2.63243213
66cytoskeletal anchoring at plasma membrane (GO:0007016)2.61435798
67inositol phosphate dephosphorylation (GO:0046855)2.61172963
68phosphorylated carbohydrate dephosphorylation (GO:0046838)2.61172963
69potassium ion homeostasis (GO:0055075)2.59442178
70positive regulation of potassium ion transport (GO:0043268)2.56695837
71membrane repolarization (GO:0086009)2.56433465
72positive regulation of potassium ion transmembrane transport (GO:1901381)2.55914141
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55764306
74regulation of striated muscle contraction (GO:0006942)2.55087786
75regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54402365
76proline transport (GO:0015824)2.53387228
77regulation of protein autophosphorylation (GO:0031952)2.53348185
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53146091
79regulation of relaxation of muscle (GO:1901077)2.51303534
80regulation of type B pancreatic cell apoptotic process (GO:2000674)2.51134351
81negative regulation of activin receptor signaling pathway (GO:0032926)2.50960747
82aspartate family amino acid catabolic process (GO:0009068)2.50897783
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.49978490
84fatty acid homeostasis (GO:0055089)2.49889834
85membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.49570366
86regulation of sequestering of triglyceride (GO:0010889)2.49401778
87carnitine transmembrane transport (GO:1902603)2.46589096
88regulation of cardiac muscle cell contraction (GO:0086004)2.46447906
89lipid particle organization (GO:0034389)2.45407796
90water-soluble vitamin biosynthetic process (GO:0042364)2.45312480
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.45197197
92response to pheromone (GO:0019236)2.44883434
93synaptic vesicle docking involved in exocytosis (GO:0016081)2.44607689
94neuromuscular junction development (GO:0007528)2.43485259
95atrial cardiac muscle cell action potential (GO:0086014)2.42073661
96regulation of potassium ion transmembrane transport (GO:1901379)2.41014559
97heart trabecula formation (GO:0060347)2.40897454
98muscle cell cellular homeostasis (GO:0046716)2.40839114
99stress fiber assembly (GO:0043149)2.40476457
100cardiac conduction (GO:0061337)2.39676733
101regulation of cofactor metabolic process (GO:0051193)2.39605367
102regulation of coenzyme metabolic process (GO:0051196)2.39605367
103regulation of the force of heart contraction (GO:0002026)2.39116728
104regulation of p38MAPK cascade (GO:1900744)2.39078005
105negative regulation of potassium ion transport (GO:0043267)2.38503546
106positive regulation of glycoprotein biosynthetic process (GO:0010560)2.37665884
107regulation of potassium ion transmembrane transporter activity (GO:1901016)2.37538553
108ribosome assembly (GO:0042255)2.36139015
109positive regulation of actin filament depolymerization (GO:0030836)2.34981781
110negative regulation of dendrite morphogenesis (GO:0050774)2.34308442
111membrane depolarization during action potential (GO:0086010)2.34079293
112glycogen catabolic process (GO:0005980)2.33973908
113detection of calcium ion (GO:0005513)2.33634354
114regulation of heart rate by cardiac conduction (GO:0086091)2.31997543
115carnitine transport (GO:0015879)2.31893109
116amino-acid betaine transport (GO:0015838)2.31893109
117regulation of fatty acid oxidation (GO:0046320)2.31591034
118glycine transport (GO:0015816)2.30604677
119branched-chain amino acid catabolic process (GO:0009083)2.29175331
120polyol catabolic process (GO:0046174)2.28989485
121positive regulation of cation channel activity (GO:2001259)2.28475362
122positive regulation of sodium ion transport (GO:0010765)2.27913255
123cardiac muscle cell action potential involved in contraction (GO:0086002)2.27400888
124membrane repolarization during action potential (GO:0086011)2.27241378
125actin filament-based movement (GO:0030048)2.27108827
126cullin deneddylation (GO:0010388)2.27066604
127regulation of oxidative phosphorylation (GO:0002082)2.26762379
128response to muscle activity (GO:0014850)2.25624316
129regulation of cation channel activity (GO:2001257)2.24990906
130regulation of DNA endoreduplication (GO:0032875)2.24799811
131cellular sodium ion homeostasis (GO:0006883)2.24691139
132cardiac muscle hypertrophy (GO:0003300)2.24669510
133regulation of ARF protein signal transduction (GO:0032012)2.24626720
134layer formation in cerebral cortex (GO:0021819)2.24534383
135cardiac muscle cell action potential (GO:0086001)2.23976237
136peptidyl-cysteine modification (GO:0018198)2.23117512
1372-oxoglutarate metabolic process (GO:0006103)2.22944529
138striated muscle hypertrophy (GO:0014897)2.20763493
139membrane tubulation (GO:0097320)2.20240475
140regulation of cardiac muscle contraction (GO:0055117)2.20048748
141regulation of sodium ion transmembrane transporter activity (GO:2000649)2.19758845
142regulation of neurotransmitter uptake (GO:0051580)2.19557933
143positive regulation of sodium ion transmembrane transport (GO:1902307)2.18071551
144regulation of sodium ion transmembrane transport (GO:1902305)2.17340705
145regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.16886274
146anterior/posterior axis specification, embryo (GO:0008595)2.13773284
147insulin secretion (GO:0030073)2.13097976
148regulation of dendritic spine development (GO:0060998)2.12681499
149presynaptic membrane assembly (GO:0097105)2.11923535
150zinc ion transport (GO:0006829)2.10951944
151negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.09476787
152somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.09429313
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.09429313
154isotype switching (GO:0045190)2.09429313
155axon ensheathment in central nervous system (GO:0032291)2.09065958
156central nervous system myelination (GO:0022010)2.09065958
157maturation of 5.8S rRNA (GO:0000460)2.08961441
158positive regulation of glycoprotein metabolic process (GO:1903020)2.07853297
159negative regulation of JUN kinase activity (GO:0043508)2.07285678
160positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.07072763
161L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.05560621
162ketone body metabolic process (GO:1902224)2.03659130
163positive regulation of meiosis (GO:0045836)2.03218182
164righting reflex (GO:0060013)2.02827596
165peptidyl-histidine modification (GO:0018202)2.02416106
166IMP biosynthetic process (GO:0006188)2.02217746
167regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.01637691
168pteridine-containing compound biosynthetic process (GO:0042559)2.01133636
169positive regulation of macroautophagy (GO:0016239)2.00949900
170IMP metabolic process (GO:0046040)2.00137294
171melanin biosynthetic process (GO:0042438)1.98843853
172negative regulation of dendrite development (GO:2000171)1.97135261
173regulation of energy homeostasis (GO:2000505)1.96424008
174replication fork processing (GO:0031297)1.96333927
175transcytosis (GO:0045056)1.95796607
176negative regulation of calcium ion transmembrane transporter activity (GO:1901020)1.95540970
177negative regulation of calcium ion transmembrane transport (GO:1903170)1.95540970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.39887174
2EZH2_22144423_ChIP-Seq_EOC_Human2.96609079
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.90487540
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54560608
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35770011
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34919860
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22972062
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22216923
9DROSHA_22980978_ChIP-Seq_HELA_Human2.17988879
10VDR_22108803_ChIP-Seq_LS180_Human2.15955141
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.11825073
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.01732573
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01678266
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01678266
15P300_19829295_ChIP-Seq_ESCs_Human2.01611479
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99962626
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99298312
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96547042
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94464219
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91327632
21FUS_26573619_Chip-Seq_HEK293_Human1.87744904
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83530605
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81901424
24* RARB_27405468_Chip-Seq_BRAIN_Mouse1.80938487
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.79454210
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74828112
27EWS_26573619_Chip-Seq_HEK293_Human1.74459390
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74266307
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67221857
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67012784
31* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66789133
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66591448
33TBX20_22080862_ChIP-Seq_HEART_Mouse1.63794133
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.63794133
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63479072
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62889793
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62639992
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62455935
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61020189
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.60846168
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.60730401
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.59790287
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59604499
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59516643
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58523531
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.57582045
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57576636
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55958318
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55197624
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53859239
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.53483302
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52973259
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52174858
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51439234
55AR_21909140_ChIP-Seq_LNCAP_Human1.51091485
56KDM2B_26808549_Chip-Seq_K562_Human1.50863986
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49549633
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48913478
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47296056
60ZNF263_19887448_ChIP-Seq_K562_Human1.47212384
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47203885
62IGF1R_20145208_ChIP-Seq_DFB_Human1.44354266
63* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43007799
64AR_21572438_ChIP-Seq_LNCaP_Human1.42340577
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42227568
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.40994381
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39030711
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.38004380
69CLOCK_20551151_ChIP-Seq_293T_Human1.37703770
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.37374275
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.36112794
72* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35722735
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.35188827
74* STAT3_23295773_ChIP-Seq_U87_Human1.34332629
75* ELK1_19687146_ChIP-ChIP_HELA_Human1.33145096
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33065716
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.32833500
78TAF15_26573619_Chip-Seq_HEK293_Human1.32599063
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31959113
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31884344
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30973510
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30630107
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29681208
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.29580525
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28927463
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.28761541
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28569910
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28411572
89AR_25329375_ChIP-Seq_VCAP_Human1.28235155
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28158187
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.27748876
92P53_22387025_ChIP-Seq_ESCs_Mouse1.25363634
93ER_23166858_ChIP-Seq_MCF-7_Human1.25098893
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24595573
95* TCF4_23295773_ChIP-Seq_U87_Human1.23641085
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23405565
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.23389251
98LXR_22158963_ChIP-Seq_LIVER_Mouse1.23180690
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.22483846
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22117827
101* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22004279
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21782786
103CDX2_22108803_ChIP-Seq_LS180_Human1.21682229
104SOX2_19829295_ChIP-Seq_ESCs_Human1.20762312
105NANOG_19829295_ChIP-Seq_ESCs_Human1.20762312
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20252862
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.20067479
108* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20029974
109TCF4_22108803_ChIP-Seq_LS180_Human1.19997840
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.18673039
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18639624
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18484785
113CBP_20019798_ChIP-Seq_JUKART_Human1.16087308
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16087308
115FOXA2_19822575_ChIP-Seq_HepG2_Human1.14901017
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14813271
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14781160
118FOXM1_23109430_ChIP-Seq_U2OS_Human1.14308536
119GBX2_23144817_ChIP-Seq_PC3_Human1.14300404
120KDM2B_26808549_Chip-Seq_DND41_Human1.14066811
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.13755977
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13676336
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13217134
124P300_18555785_Chip-Seq_ESCs_Mouse1.13026794
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13017148
126* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.11541759
127AHR_22903824_ChIP-Seq_MCF-7_Human1.10764211
128REST_21632747_ChIP-Seq_MESCs_Mouse1.10636804
129DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10391294
130* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10353563
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10006283
132* REST_18959480_ChIP-ChIP_MESCs_Mouse1.09467545
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09426081
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09051641
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.08490381
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.08111712
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07791572
138OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07019056
139E2F7_22180533_ChIP-Seq_HELA_Human1.06332073
140TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05591642
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04847070
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03724665
143FLI1_21867929_ChIP-Seq_TH2_Mouse1.03580094
144RXR_22108803_ChIP-Seq_LS180_Human1.03403156
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02853557
146EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02693505
147SOX2_21211035_ChIP-Seq_LN229_Gbm1.02668643
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01949037
149SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01844842
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01129582
151CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01091916
152PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00878033
153SOX9_26525672_Chip-Seq_HEART_Mouse1.00864452
154ARNT_22903824_ChIP-Seq_MCF-7_Human1.00718447
155PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00622484
156AR_19668381_ChIP-Seq_PC3_Human0.99751341
157RXR_22158963_ChIP-Seq_LIVER_Mouse0.99561003
158CTCF_27219007_Chip-Seq_Bcells_Human0.98953896
159CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98305890
160LXR_22292898_ChIP-Seq_THP-1_Human0.97374372
161KDM2B_26808549_Chip-Seq_JURKAT_Human0.97061551
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.95865680
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94905422
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94807433
165RING1B_27294783_Chip-Seq_ESCs_Mouse0.94432392
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.93042196
167GATA1_19941826_ChIP-Seq_K562_Human0.93027404
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92940915
169SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91871782
170GATA2_21666600_ChIP-Seq_HMVEC_Human0.91761922
171SMAD3_21741376_ChIP-Seq_HESCs_Human0.91489942
172NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91136498
173NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91136498
174ZNF274_21170338_ChIP-Seq_K562_Hela0.91134119
175SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90069841
176PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88999517
177ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88909604
178KLF4_19829295_ChIP-Seq_ESCs_Human0.87990263
179CREB1_26743006_Chip-Seq_LNCaP_Human0.87537831
180PIAS1_25552417_ChIP-Seq_VCAP_Human0.86332271
181STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86001344
182SMAD4_21799915_ChIP-Seq_A2780_Human0.85159276
183* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84835395
184VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84259456
185BCAT_22108803_ChIP-Seq_LS180_Human0.84184315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.19755065
2MP0000751_myopathy3.89837209
3MP0003646_muscle_fatigue3.40270355
4MP0004084_abnormal_cardiac_muscle3.07698479
5MP0004036_abnormal_muscle_relaxation3.04019640
6MP0004145_abnormal_muscle_electrophysio2.99736778
7MP0000372_irregular_coat_pigmentation2.91996547
8MP0004859_abnormal_synaptic_plasticity2.80780488
9MP0004130_abnormal_muscle_cell2.80777936
10MP0000749_muscle_degeneration2.78162832
11MP0010234_abnormal_vibrissa_follicle2.56882683
12MP0004215_abnormal_myocardial_fiber2.56076604
13MP0003195_calcinosis2.40550731
14MP0000747_muscle_weakness2.33677385
15MP0004087_abnormal_muscle_fiber2.32466186
16MP0005330_cardiomyopathy2.19598229
17MP0009780_abnormal_chondrocyte_physiolo2.05055572
18MP0005620_abnormal_muscle_contractility2.03382897
19MP0004185_abnormal_adipocyte_glucose1.97686237
20MP0005666_abnormal_adipose_tissue1.94951761
21MP0002972_abnormal_cardiac_muscle1.90111201
22MP0005171_absent_coat_pigmentation1.87507203
23MP0002106_abnormal_muscle_physiology1.85478572
24MP0002102_abnormal_ear_morphology1.85093788
25MP0004484_altered_response_of1.83585733
26MP0002909_abnormal_adrenal_gland1.83535654
27MP0002269_muscular_atrophy1.81115114
28MP0004270_analgesia1.77007009
29MP0000759_abnormal_skeletal_muscle1.72980263
30MP0004233_abnormal_muscle_weight1.71562869
31MP0000013_abnormal_adipose_tissue1.71141453
32MP0003137_abnormal_impulse_conducting1.70276916
33MP0003635_abnormal_synaptic_transmissio1.67170143
34MP0001661_extended_life_span1.66356559
35MP0004043_abnormal_pH_regulation1.64756328
36MP0003329_amyloid_beta_deposits1.62790368
37MP0008775_abnormal_heart_ventricle1.62282876
38MP0005375_adipose_tissue_phenotype1.62110266
39MP0000750_abnormal_muscle_regeneration1.61968087
40MP0005369_muscle_phenotype1.61811108
41MP0006138_congestive_heart_failure1.58681551
42MP0005623_abnormal_meninges_morphology1.58389815
43MP0003690_abnormal_glial_cell1.57090829
44MP0004085_abnormal_heartbeat1.56106619
45MP0001544_abnormal_cardiovascular_syste1.48632861
46MP0005385_cardiovascular_system_phenoty1.48632861
47MP0002938_white_spotting1.44941438
48MP0010630_abnormal_cardiac_muscle1.44022982
49MP0003950_abnormal_plasma_membrane1.43811313
50MP0001984_abnormal_olfaction1.42839564
51MP0005670_abnormal_white_adipose1.42633738
52MP0008569_lethality_at_weaning1.42580016
53MP0010094_abnormal_chromosome_stability1.39603310
54MP0000003_abnormal_adipose_tissue1.37689296
55MP0008877_abnormal_DNA_methylation1.36065154
56MP0000920_abnormal_myelination1.34758655
57MP0005646_abnormal_pituitary_gland1.34317453
58MP0008057_abnormal_DNA_replication1.33512173
59MP0002064_seizures1.33273122
60MP0005167_abnormal_blood-brain_barrier1.32892467
61MP0002822_catalepsy1.29287525
62MP0005379_endocrine/exocrine_gland_phen1.27939398
63MP0009046_muscle_twitch1.27848988
64MP0003705_abnormal_hypodermis_morpholog1.24943735
65MP0003136_yellow_coat_color1.23617769
66MP0005408_hypopigmentation1.21742728
67MP0004858_abnormal_nervous_system1.21279325
68MP0008961_abnormal_basal_metabolism1.20376436
69MP0009745_abnormal_behavioral_response1.19789248
70MP0002272_abnormal_nervous_system1.19757284
71MP0002638_abnormal_pupillary_reflex1.18621172
72MP0004885_abnormal_endolymph1.18238879
73MP0005187_abnormal_penis_morphology1.15210451
74MP0005253_abnormal_eye_physiology1.14147218
75MP0002063_abnormal_learning/memory/cond1.11891680
76MP0002108_abnormal_muscle_morphology1.09921411
77MP0003633_abnormal_nervous_system1.08918542
78MP0005551_abnormal_eye_electrophysiolog1.08206975
79MP0008058_abnormal_DNA_repair1.07560508
80MP0002971_abnormal_brown_adipose1.07541037
81MP0001486_abnormal_startle_reflex1.06100301
82MP0002332_abnormal_exercise_endurance1.04921275
83MP0006054_spinal_hemorrhage1.03592590
84MP0003880_abnormal_central_pattern1.01017708
85MP0003221_abnormal_cardiomyocyte_apopto0.99481334
86MP0001299_abnormal_eye_distance/0.98900609
87MP0010352_gastrointestinal_tract_polyps0.98145316
88MP0005367_renal/urinary_system_phenotyp0.97262509
89MP0000516_abnormal_urinary_system0.97262509
90MP0002876_abnormal_thyroid_physiology0.96701448
91MP0003045_fibrosis0.96223930
92MP0000427_abnormal_hair_cycle0.95378944
93MP0003890_abnormal_embryonic-extraembry0.95068742
94MP0010678_abnormal_skin_adnexa0.94682487
95MP0001440_abnormal_grooming_behavior0.93630074
96MP0001485_abnormal_pinna_reflex0.93373370
97MP0000015_abnormal_ear_pigmentation0.92124888
98MP0005075_abnormal_melanosome_morpholog0.92113408
99MP0001944_abnormal_pancreas_morphology0.91901290
100MP0006072_abnormal_retinal_apoptosis0.91646414
101MP0003634_abnormal_glial_cell0.91327471
102MP0004510_myositis0.91299154
103MP0003787_abnormal_imprinting0.90369802
104MP0008007_abnormal_cellular_replicative0.90269452
105MP0005535_abnormal_body_temperature0.89841232
106MP0001968_abnormal_touch/_nociception0.89492380
107MP0009697_abnormal_copulation0.89010411
108MP0002734_abnormal_mechanical_nocicepti0.88220293
109MP0002090_abnormal_vision0.87988471
110MP0010368_abnormal_lymphatic_system0.87343830
111MP0002234_abnormal_pharynx_morphology0.86393627
112MP0008438_abnormal_cutaneous_collagen0.85959037
113MP0001958_emphysema0.85103002
114MP0002118_abnormal_lipid_homeostasis0.84475102
115MP0003111_abnormal_nucleus_morphology0.82903039
116MP0000230_abnormal_systemic_arterial0.82398250
117MP0002572_abnormal_emotion/affect_behav0.81361631
118MP0002160_abnormal_reproductive_system0.79523582
119MP0008872_abnormal_physiological_respon0.79114781
120MP0004924_abnormal_behavior0.79098131
121MP0005386_behavior/neurological_phenoty0.79098131
122MP0003631_nervous_system_phenotype0.78328506
123MP0000733_abnormal_muscle_development0.78274588
124MP0003122_maternal_imprinting0.78271946
125MP0003937_abnormal_limbs/digits/tail_de0.77941506
126MP0002877_abnormal_melanocyte_morpholog0.77709226
127MP0002067_abnormal_sensory_capabilities0.77278231
128MP0001501_abnormal_sleep_pattern0.76959941
129MP0001177_atelectasis0.75953529
130MP0003123_paternal_imprinting0.75692831
131MP0000647_abnormal_sebaceous_gland0.75002205
132MP0003075_altered_response_to0.74868480
133MP0002066_abnormal_motor_capabilities/c0.74717481
134MP0009672_abnormal_birth_weight0.74245985
135MP0006036_abnormal_mitochondrial_physio0.74116323
136MP0002139_abnormal_hepatobiliary_system0.74101178
137MP0004272_abnormal_basement_membrane0.73421079
138MP0003119_abnormal_digestive_system0.72822292
139MP0000604_amyloidosis0.72658513
140MP0002736_abnormal_nociception_after0.72356617
141MP0002229_neurodegeneration0.72265727
142MP0002163_abnormal_gland_morphology0.71937288
143MP0009384_cardiac_valve_regurgitation0.71218596
144MP0003718_maternal_effect0.70911281
145MP0004957_abnormal_blastocyst_morpholog0.70639509
146MP0002078_abnormal_glucose_homeostasis0.70340757
147MP0003828_pulmonary_edema0.69325949
148MP0003283_abnormal_digestive_organ0.68359675
149MP0005165_increased_susceptibility_to0.67907401
150MP0003279_aneurysm0.66647421
151MP0001970_abnormal_pain_threshold0.66079143

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.40462069
2Exercise-induced muscle cramps (HP:0003710)4.76021025
3Sudden death (HP:0001699)4.58913459
4Hyporeflexia of lower limbs (HP:0002600)4.41978886
5Muscle fiber splitting (HP:0003555)4.23610572
6Muscle hypertrophy of the lower extremities (HP:0008968)4.18570093
7Calf muscle hypertrophy (HP:0008981)4.15511289
8Difficulty running (HP:0009046)4.04726846
9Myoglobinuria (HP:0002913)4.00423278
10Bundle branch block (HP:0011710)3.68919802
11Abnormality of the calf musculature (HP:0001430)3.48711010
12Hypoglycemic seizures (HP:0002173)3.35697900
13Atrial fibrillation (HP:0005110)3.26658919
14EMG: myopathic abnormalities (HP:0003458)3.18679265
15Myotonia (HP:0002486)3.09601782
16Ventricular tachycardia (HP:0004756)3.09006030
17Subaortic stenosis (HP:0001682)3.05993784
18Abnormality of the left ventricular outflow tract (HP:0011103)3.05993784
19Increased variability in muscle fiber diameter (HP:0003557)3.03521802
20Primary atrial arrhythmia (HP:0001692)3.02544498
21Muscle fiber inclusion bodies (HP:0100299)2.98841933
22Ventricular fibrillation (HP:0001663)2.97794276
23Hyperglycemia (HP:0003074)2.97420638
24Type 1 muscle fiber predominance (HP:0003803)2.95692992
25Prolonged QT interval (HP:0001657)2.95186653
26Pancreatic islet-cell hyperplasia (HP:0004510)2.94157937
27Increased connective tissue (HP:0009025)2.90705919
28Muscle stiffness (HP:0003552)2.89785039
29Abnormality of the pancreatic islet cells (HP:0006476)2.88335120
30Abnormality of endocrine pancreas physiology (HP:0012093)2.88335120
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.86943552
32Syncope (HP:0001279)2.85130567
33Asymmetric septal hypertrophy (HP:0001670)2.80949851
34Supraventricular tachycardia (HP:0004755)2.80867399
35Neoplasm of the adrenal cortex (HP:0100641)2.79319893
36Supraventricular arrhythmia (HP:0005115)2.78710343
37Hypothermia (HP:0002045)2.76967216
38Heart block (HP:0012722)2.76659927
39Abnormality of skeletal muscle fiber size (HP:0012084)2.70850610
40Action tremor (HP:0002345)2.67561915
41Abnormal atrioventricular conduction (HP:0005150)2.64783398
42Neoplasm of the adrenal gland (HP:0100631)2.62185676
43Broad metatarsal (HP:0001783)2.60776181
44Right ventricular cardiomyopathy (HP:0011663)2.57576378
45Ventricular arrhythmia (HP:0004308)2.55130425
46Atrioventricular block (HP:0001678)2.54882418
47Pheochromocytoma (HP:0002666)2.53255527
48Dysmetric saccades (HP:0000641)2.52829050
49Myokymia (HP:0002411)2.49514314
50Tongue fasciculations (HP:0001308)2.47429328
51Difficulty climbing stairs (HP:0003551)2.47006442
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.46808831
53Hypoplasia of the fovea (HP:0007750)2.46808831
54Lipoatrophy (HP:0100578)2.42418487
55Ketoacidosis (HP:0001993)2.39353388
56Nemaline bodies (HP:0003798)2.38902359
57Rhabdomyolysis (HP:0003201)2.36048214
58Focal motor seizures (HP:0011153)2.32313356
59Round ear (HP:0100830)2.31721065
60Supranuclear gaze palsy (HP:0000605)2.30778511
61Neurofibrillary tangles (HP:0002185)2.27092544
62Progressive macrocephaly (HP:0004481)2.26792621
63Scapular winging (HP:0003691)2.26039836
64Rapidly progressive (HP:0003678)2.23882281
65Insulin-resistant diabetes mellitus (HP:0000831)2.22620222
66Abnormality of the fovea (HP:0000493)2.22377332
67Dilated cardiomyopathy (HP:0001644)2.21023282
68Cutaneous melanoma (HP:0012056)2.19120091
69Visual hallucinations (HP:0002367)2.18125431
70Cerebral inclusion bodies (HP:0100314)2.18095827
71Delayed gross motor development (HP:0002194)2.17659935
72Enlarged penis (HP:0000040)2.17440255
73Sensory axonal neuropathy (HP:0003390)2.15797333
74Abnormal EKG (HP:0003115)2.14437445
75Aqueductal stenosis (HP:0002410)2.10377064
76Symptomatic seizures (HP:0011145)2.08050000
77Intestinal atresia (HP:0011100)2.06743669
78Dysdiadochokinesis (HP:0002075)2.04397906
79Muscle fibrillation (HP:0010546)2.03677866
80Gowers sign (HP:0003391)2.01775039
81Astrocytoma (HP:0009592)2.01621708
82Abnormality of the astrocytes (HP:0100707)2.01621708
83Hyperkalemia (HP:0002153)2.01118280
84Ependymoma (HP:0002888)2.00877935
85Achilles tendon contracture (HP:0001771)2.00812397
86Neuroendocrine neoplasm (HP:0100634)1.99447026
87Abnormality of glycolysis (HP:0004366)1.97902264
88Areflexia of lower limbs (HP:0002522)1.96593927
89Neck muscle weakness (HP:0000467)1.96202518
90Palpitations (HP:0001962)1.95079940
91Insidious onset (HP:0003587)1.94714500
92Termporal pattern (HP:0011008)1.94714500
93Ketosis (HP:0001946)1.94418347
94Postural instability (HP:0002172)1.92855444
95Intention tremor (HP:0002080)1.92675563
96Foot dorsiflexor weakness (HP:0009027)1.92192193
97Double outlet right ventricle (HP:0001719)1.89826543
98Congenital malformation of the right heart (HP:0011723)1.89826543
99Hypoglycemic coma (HP:0001325)1.89741822
100Abnormality of the Achilles tendon (HP:0005109)1.88952660
101Glioma (HP:0009733)1.87549139
102Frequent falls (HP:0002359)1.87360199
103Hypoplastic ischia (HP:0003175)1.86579034
104Hamartoma of the eye (HP:0010568)1.86474992
105Resting tremor (HP:0002322)1.86234489
106Central scotoma (HP:0000603)1.86229658
107Stridor (HP:0010307)1.86064264
108Focal seizures (HP:0007359)1.85767939
109Limb-girdle muscle atrophy (HP:0003797)1.85747782
110Dysmetria (HP:0001310)1.83908320
111Patchy hypopigmentation of hair (HP:0011365)1.83264257
112Abnormality of the foot musculature (HP:0001436)1.83204888
113Hypomagnesemia (HP:0002917)1.82570079
114Abnormality of the labia minora (HP:0012880)1.81511090
115Prominent metopic ridge (HP:0005487)1.80658469
116Meningioma (HP:0002858)1.80144024
117Breast carcinoma (HP:0003002)1.80035434
118Cerebral hypomyelination (HP:0006808)1.79621087
119Mildly elevated creatine phosphokinase (HP:0008180)1.79080332
120Distal arthrogryposis (HP:0005684)1.78907631
121Febrile seizures (HP:0002373)1.78881940
122Urinary urgency (HP:0000012)1.78668599
123Hyperinsulinemic hypoglycemia (HP:0000825)1.78278676
124Depression (HP:0000716)1.78200683
125Progressive inability to walk (HP:0002505)1.77366429
126Lower limb amyotrophy (HP:0007210)1.77138413
127EMG: neuropathic changes (HP:0003445)1.77100666
128Impaired social interactions (HP:0000735)1.76994899
129Abnormal social behavior (HP:0012433)1.76994899
130Anxiety (HP:0000739)1.75863522
131White forelock (HP:0002211)1.74648602
132Distal lower limb amyotrophy (HP:0008944)1.74163063
133Atonic seizures (HP:0010819)1.73670567
134Cerebral hemorrhage (HP:0001342)1.72665507
135Hemiplegia (HP:0002301)1.72451866
136Absent phalangeal crease (HP:0006109)1.72083777
137Proximal amyotrophy (HP:0007126)1.71173845
138Methylmalonic acidemia (HP:0002912)1.70840119
139Cerebral aneurysm (HP:0004944)1.69954053
140Popliteal pterygium (HP:0009756)1.69419463
141Acute necrotizing encephalopathy (HP:0006965)1.69401106
142Aplasia/Hypoplasia of the macula (HP:0008059)1.69317288
143Abnormality of methionine metabolism (HP:0010901)1.68871605
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68215004
145Generalized tonic-clonic seizures (HP:0002069)1.68029979
146Myopathic facies (HP:0002058)1.67662226
147Urethral obstruction (HP:0000796)1.67385078
148Hemiparesis (HP:0001269)1.67110107
149Large for gestational age (HP:0001520)1.66106530
150Ankle clonus (HP:0011448)1.65694368
151Increased serum pyruvate (HP:0003542)1.65046835
152Conjunctival hamartoma (HP:0100780)1.63811711
153Abnormality of the ischium (HP:0003174)1.63809587
154Rimmed vacuoles (HP:0003805)1.62876948
155Late onset (HP:0003584)1.60810621
156Chromsome breakage (HP:0040012)1.60664431
157Neoplasm of the peripheral nervous system (HP:0100007)1.60506296
158Abnormality of aromatic amino acid family metabolism (HP:0004338)1.57928926
159Abnormal auditory evoked potentials (HP:0006958)1.57841541
160Acute encephalopathy (HP:0006846)1.55534057
161Epileptiform EEG discharges (HP:0011182)1.54879680
162Abnormality of the metopic suture (HP:0005556)1.54293442
163Aplasia/Hypoplasia affecting the retina (HP:0008061)1.53565351
164Broad-based gait (HP:0002136)1.53030305
165Muscular hypotonia of the trunk (HP:0008936)1.52933166
166Increased circulating renin level (HP:0000848)1.52695311
167Meckel diverticulum (HP:0002245)1.52450678
168Increased CSF lactate (HP:0002490)1.52169469
169High pitched voice (HP:0001620)1.50835508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.28409343
2TRIB33.71298818
3TTN3.23658963
4EIF2AK33.02378600
5PHKG12.98142146
6PHKG22.98142146
7EIF2AK12.85068663
8BMPR1B2.58799691
9TRIM282.51428256
10MST42.48900048
11PRKD32.48007008
12PLK22.41503171
13LMTK22.41479849
14MKNK22.34910219
15PKN22.17487184
16PLK32.16786497
17DMPK2.16258163
18OBSCN2.15307070
19TNIK2.10978103
20PINK12.01111223
21ERBB31.96797026
22WNK11.82743920
23RIPK11.76753841
24TSSK61.72612846
25BUB11.70878631
26PDK31.67994433
27PDK41.67994433
28PAK61.63931004
29WNK41.62888105
30STK391.60449551
31WNK31.59019069
32KSR21.58077821
33MAP3K91.57940402
34NUAK11.51074429
35NTRK31.44908503
36PRKCH1.38902358
37ACVR1B1.38427089
38CAMKK11.36292273
39MAP3K71.34139138
40EPHB11.33142854
41WEE11.32088489
42PDGFRA1.31598637
43CAMK1G1.29648321
44MAP3K41.26505695
45PRKD11.22365711
46NTRK11.21315717
47MKNK11.19952477
48STK38L1.19465262
49STK381.19463727
50EPHA41.17377573
51PAK31.15388029
52BCKDK1.13846168
53CASK1.13797655
54PDK21.12416868
55MAP2K41.11899066
56TTK1.11218074
57FGFR21.10782782
58GRK11.09811438
59PIK3CA1.07917764
60PBK1.06006579
61TYRO31.05875877
62DAPK21.05483057
63RET1.03250545
64PTK61.01307639
65MAP3K20.98874535
66ZAK0.97986297
67TIE10.97893253
68ICK0.97781229
69PDPK10.97692086
70CAMK1D0.97222103
71CSNK1G10.91962329
72OXSR10.91872289
73SIK10.91482282
74STK30.91010505
75CAMK2D0.89541604
76SGK4940.88339488
77SGK2230.88339488
78MAP3K120.88075956
79STK240.87953774
80LIMK10.85923759
81PDK10.84845941
82NEK10.84211069
83PLK40.83823717
84SGK30.83504359
85LATS10.83279128
86PLK10.83113308
87BRSK20.81769403
88MINK10.81584976
89EIF2AK20.80258066
90SIK30.80044803
91TRPM70.77100324
92STK110.76520842
93TAOK10.76434342
94ROCK20.75126224
95UHMK10.74936835
96CDK50.74631649
97CAMKK20.74561134
98INSRR0.73535633
99CSNK1G20.72797761
100PRKAA10.72445157
101MYLK0.72363007
102LATS20.72218051
103PNCK0.71471226
104MAPK120.71237236
105ALK0.70574486
106PRKCE0.69962153
107FGFR10.69771502
108PTK2B0.69345911
109CAMK2G0.68986946
110BRSK10.68893826
111CSNK1G30.68453057
112ROCK10.67517810
113PRKAA20.67269188
114PKN10.67141769
115MAP3K10.66904956
116VRK20.66780000
117CDC42BPA0.65876204
118PRKCG0.65040054
119CSNK1A1L0.64760430
120CAMK2A0.62569139
121BCR0.62092002
122MARK20.61904977
123MAPKAPK30.61030803
124CAMK10.59950233
125PDGFRB0.59725033
126BMX0.59566034
127NTRK20.58350444
128NLK0.58302748
129SGK10.56904975
130MUSK0.56397615
131ERBB40.56249891
132DAPK10.55361528
133TAF10.54334240
134GRK50.54107774
135FER0.53913166
136PRKD20.52950385
137NME10.52559011
138ILK0.51742050
139MAPKAPK50.51510993
140CAMK40.50269641
141CAMK2B0.49465352
142RPS6KA30.48326458
143ATM0.48230224
144LRRK20.47147382
145MAP2K10.46570841
146MAPK130.46408605
147DDR20.45171283
148AKT30.44878273
149PRKCI0.44287329
150AKT20.44081076
151PTK20.44037529
152CCNB10.42945060
153JAK10.42927969
154PRKACG0.42848384
155SGK20.42481717
156MET0.41868595
157ADRBK20.38815907
158MAP4K20.37495860
159FGFR30.36319900
160PRKG10.33717078

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.10182960
2Vitamin B6 metabolism_Homo sapiens_hsa007503.09478751
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53513763
4Proteasome_Homo sapiens_hsa030502.39154602
5Protein export_Homo sapiens_hsa030602.19617095
6Non-homologous end-joining_Homo sapiens_hsa034502.15730289
7Dilated cardiomyopathy_Homo sapiens_hsa054142.00878158
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.99467352
9Propanoate metabolism_Homo sapiens_hsa006401.96105983
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91958295
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79249921
12Cardiac muscle contraction_Homo sapiens_hsa042601.77051790
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70139665
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68223420
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66403359
16Fatty acid degradation_Homo sapiens_hsa000711.60832449
17Fatty acid metabolism_Homo sapiens_hsa012121.60077615
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58108370
19Selenocompound metabolism_Homo sapiens_hsa004501.57401583
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57189500
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48148112
22Gastric acid secretion_Homo sapiens_hsa049711.47435030
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46698310
24Circadian rhythm_Homo sapiens_hsa047101.44654882
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44190798
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43881483
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39064455
28Fatty acid biosynthesis_Homo sapiens_hsa000611.34110646
29GABAergic synapse_Homo sapiens_hsa047271.32601102
30Insulin secretion_Homo sapiens_hsa049111.31824522
31Circadian entrainment_Homo sapiens_hsa047131.31255731
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29594965
33Butanoate metabolism_Homo sapiens_hsa006501.27969625
34Oocyte meiosis_Homo sapiens_hsa041141.26785339
35beta-Alanine metabolism_Homo sapiens_hsa004101.24748608
36Renin secretion_Homo sapiens_hsa049241.22061945
37Salivary secretion_Homo sapiens_hsa049701.22016192
38Oxytocin signaling pathway_Homo sapiens_hsa049211.20832209
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20735622
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19551869
41Long-term potentiation_Homo sapiens_hsa047201.18623873
42One carbon pool by folate_Homo sapiens_hsa006701.17950729
43RNA degradation_Homo sapiens_hsa030181.16323202
44Basal transcription factors_Homo sapiens_hsa030221.16043196
45Glutamatergic synapse_Homo sapiens_hsa047241.15523114
46Morphine addiction_Homo sapiens_hsa050321.14615967
47Arginine biosynthesis_Homo sapiens_hsa002201.12897518
48Synaptic vesicle cycle_Homo sapiens_hsa047211.12390032
49Type II diabetes mellitus_Homo sapiens_hsa049301.12269247
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11208059
51Olfactory transduction_Homo sapiens_hsa047401.11159892
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10782358
53PPAR signaling pathway_Homo sapiens_hsa033201.10649312
54RNA polymerase_Homo sapiens_hsa030201.08371994
55Cholinergic synapse_Homo sapiens_hsa047251.08092369
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.07889591
57RNA transport_Homo sapiens_hsa030131.07287603
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04953838
59Carbon metabolism_Homo sapiens_hsa012001.01808732
60Homologous recombination_Homo sapiens_hsa034401.01508818
61Adipocytokine signaling pathway_Homo sapiens_hsa049201.01486127
62Calcium signaling pathway_Homo sapiens_hsa040201.00305138
63Arginine and proline metabolism_Homo sapiens_hsa003300.99349557
64Dopaminergic synapse_Homo sapiens_hsa047280.96888036
65Bile secretion_Homo sapiens_hsa049760.96670585
66Glucagon signaling pathway_Homo sapiens_hsa049220.95636321
67GnRH signaling pathway_Homo sapiens_hsa049120.95417692
68Amphetamine addiction_Homo sapiens_hsa050310.94467499
69Fanconi anemia pathway_Homo sapiens_hsa034600.93480833
70cAMP signaling pathway_Homo sapiens_hsa040240.93295953
71Folate biosynthesis_Homo sapiens_hsa007900.93294406
72Insulin resistance_Homo sapiens_hsa049310.93021482
73Dorso-ventral axis formation_Homo sapiens_hsa043200.91369085
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90368648
75Pyruvate metabolism_Homo sapiens_hsa006200.89961428
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.88521790
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87837382
78Hippo signaling pathway_Homo sapiens_hsa043900.87701981
79Insulin signaling pathway_Homo sapiens_hsa049100.86266358
80Phototransduction_Homo sapiens_hsa047440.86264526
81Oxidative phosphorylation_Homo sapiens_hsa001900.84847846
82Fatty acid elongation_Homo sapiens_hsa000620.83319206
83Long-term depression_Homo sapiens_hsa047300.82560829
84Gap junction_Homo sapiens_hsa045400.82556973
85Mismatch repair_Homo sapiens_hsa034300.81802558
86Sulfur metabolism_Homo sapiens_hsa009200.80269460
87AMPK signaling pathway_Homo sapiens_hsa041520.79927928
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79540881
89Purine metabolism_Homo sapiens_hsa002300.79112674
90Nicotine addiction_Homo sapiens_hsa050330.79087020
91Estrogen signaling pathway_Homo sapiens_hsa049150.78207601
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78058794
93Renal cell carcinoma_Homo sapiens_hsa052110.75049375
94Taste transduction_Homo sapiens_hsa047420.73910768
95Pancreatic secretion_Homo sapiens_hsa049720.73872303
96Peroxisome_Homo sapiens_hsa041460.72672514
97Cocaine addiction_Homo sapiens_hsa050300.71817449
98Focal adhesion_Homo sapiens_hsa045100.71682372
99Steroid biosynthesis_Homo sapiens_hsa001000.69768717
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.69631771
101Collecting duct acid secretion_Homo sapiens_hsa049660.69245927
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69118515
103Glioma_Homo sapiens_hsa052140.68794077
104Wnt signaling pathway_Homo sapiens_hsa043100.68507357
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68335199
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67813491
107Regulation of autophagy_Homo sapiens_hsa041400.67492092
108TGF-beta signaling pathway_Homo sapiens_hsa043500.67328557
109Tight junction_Homo sapiens_hsa045300.67104415
110Adherens junction_Homo sapiens_hsa045200.66473470
111Parkinsons disease_Homo sapiens_hsa050120.66373366
112VEGF signaling pathway_Homo sapiens_hsa043700.66199953
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66148883
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65037019
115mTOR signaling pathway_Homo sapiens_hsa041500.62031751
116Histidine metabolism_Homo sapiens_hsa003400.60617202
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60139309
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58645930
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57613952
120Starch and sucrose metabolism_Homo sapiens_hsa005000.57445094
121Thyroid hormone synthesis_Homo sapiens_hsa049180.56817565
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55969757
123Mineral absorption_Homo sapiens_hsa049780.54463183
124Melanogenesis_Homo sapiens_hsa049160.53763062
125Glycerolipid metabolism_Homo sapiens_hsa005610.52346391
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51580857
127Glutathione metabolism_Homo sapiens_hsa004800.51455891
128Tryptophan metabolism_Homo sapiens_hsa003800.50478746
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49773394
130Endocytosis_Homo sapiens_hsa041440.49261917
131Serotonergic synapse_Homo sapiens_hsa047260.48968055
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47802341
133Hedgehog signaling pathway_Homo sapiens_hsa043400.47721604
134Cell cycle_Homo sapiens_hsa041100.47524884
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.47024351
136MAPK signaling pathway_Homo sapiens_hsa040100.46968513
137ECM-receptor interaction_Homo sapiens_hsa045120.46953544
138Alzheimers disease_Homo sapiens_hsa050100.46725604
139Amoebiasis_Homo sapiens_hsa051460.46499105
140Lysine degradation_Homo sapiens_hsa003100.45857049
141Metabolic pathways_Homo sapiens_hsa011000.45706179
142Ovarian steroidogenesis_Homo sapiens_hsa049130.45567338
143Proteoglycans in cancer_Homo sapiens_hsa052050.45078138
144ErbB signaling pathway_Homo sapiens_hsa040120.44982678
145Choline metabolism in cancer_Homo sapiens_hsa052310.44260836
146Sphingolipid metabolism_Homo sapiens_hsa006000.43869795
147Axon guidance_Homo sapiens_hsa043600.43838455
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43270700
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42488945

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