

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sperm-egg recognition (GO:0035036) | 9.94636651 |
| 2 | multicellular organism reproduction (GO:0032504) | 9.79957980 |
| 3 | acrosome reaction (GO:0007340) | 9.62302477 |
| 4 | epithelial cilium movement (GO:0003351) | 9.49570488 |
| 5 | plasma membrane fusion (GO:0045026) | 9.32369669 |
| 6 | binding of sperm to zona pellucida (GO:0007339) | 8.98732173 |
| 7 | cilium movement (GO:0003341) | 8.86855326 |
| 8 | cell-cell recognition (GO:0009988) | 8.84801257 |
| 9 | motile cilium assembly (GO:0044458) | 8.64132046 |
| 10 | spermatid development (GO:0007286) | 8.37400552 |
| 11 | reproduction (GO:0000003) | 8.16194491 |
| 12 | piRNA metabolic process (GO:0034587) | 8.12530301 |
| 13 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 7.90623055 |
| 14 | regulation of cilium movement (GO:0003352) | 7.74872726 |
| 15 | male meiosis (GO:0007140) | 7.70806149 |
| 16 | synaptonemal complex organization (GO:0070193) | 7.31068748 |
| 17 | synaptonemal complex assembly (GO:0007130) | 6.99808546 |
| 18 | single fertilization (GO:0007338) | 6.61379181 |
| 19 | negative regulation of inclusion body assembly (GO:0090084) | 6.03302278 |
| 20 | sperm capacitation (GO:0048240) | 5.89346946 |
| 21 | fertilization (GO:0009566) | 5.67261799 |
| 22 | ventricular system development (GO:0021591) | 5.65716035 |
| 23 | spermatogenesis (GO:0007283) | 5.48891878 |
| 24 | male gamete generation (GO:0048232) | 5.47072683 |
| 25 | male meiosis I (GO:0007141) | 5.33612317 |
| 26 | calcium ion-dependent exocytosis (GO:0017156) | 5.26900039 |
| 27 | DNA methylation involved in gamete generation (GO:0043046) | 5.15070606 |
| 28 | gamete generation (GO:0007276) | 5.04782935 |
| 29 | regulation of inclusion body assembly (GO:0090083) | 5.00298372 |
| 30 | microtubule severing (GO:0051013) | 4.89843281 |
| 31 | regulation of microtubule-based movement (GO:0060632) | 4.87150300 |
| 32 | dopamine transport (GO:0015872) | 4.86435019 |
| 33 | microtubule depolymerization (GO:0007019) | 4.83280770 |
| 34 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 4.81861407 |
| 35 | cell recognition (GO:0008037) | 4.76570183 |
| 36 | germ cell development (GO:0007281) | 4.74879466 |
| 37 | organic cation transport (GO:0015695) | 4.73544946 |
| 38 | chromosome organization involved in meiosis (GO:0070192) | 4.68743440 |
| 39 | meiotic nuclear division (GO:0007126) | 4.52800788 |
| 40 | protein localization to cilium (GO:0061512) | 4.46455820 |
| 41 | meiosis I (GO:0007127) | 4.39966197 |
| 42 | spermatid nucleus differentiation (GO:0007289) | 4.39261613 |
| 43 | photoreceptor cell maintenance (GO:0045494) | 4.30255035 |
| 44 | nonmotile primary cilium assembly (GO:0035058) | 4.27656275 |
| 45 | left/right pattern formation (GO:0060972) | 4.23959585 |
| 46 | axoneme assembly (GO:0035082) | 4.22030076 |
| 47 | seminiferous tubule development (GO:0072520) | 4.11679185 |
| 48 | multicellular organismal reproductive process (GO:0048609) | 3.97188195 |
| 49 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.95762872 |
| 50 | L-fucose catabolic process (GO:0042355) | 3.92229483 |
| 51 | fucose catabolic process (GO:0019317) | 3.92229483 |
| 52 | L-fucose metabolic process (GO:0042354) | 3.92229483 |
| 53 | intraciliary transport (GO:0042073) | 3.88335268 |
| 54 | serotonin metabolic process (GO:0042428) | 3.87722711 |
| 55 | protein polyglutamylation (GO:0018095) | 3.71760027 |
| 56 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.71336113 |
| 57 | primary amino compound metabolic process (GO:1901160) | 3.66280725 |
| 58 | meiotic cell cycle (GO:0051321) | 3.62959482 |
| 59 | indolalkylamine metabolic process (GO:0006586) | 3.58490515 |
| 60 | microtubule-based movement (GO:0007018) | 3.55907720 |
| 61 | genitalia morphogenesis (GO:0035112) | 3.53916161 |
| 62 | cilium organization (GO:0044782) | 3.47241280 |
| 63 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 3.33970688 |
| 64 | cilium assembly (GO:0042384) | 3.33374517 |
| 65 | retinal cone cell development (GO:0046549) | 3.31054109 |
| 66 | regulation of acrosome reaction (GO:0060046) | 3.26993349 |
| 67 | response to pheromone (GO:0019236) | 3.24220345 |
| 68 | cilium morphogenesis (GO:0060271) | 3.24169464 |
| 69 | chaperone-mediated protein complex assembly (GO:0051131) | 3.23708986 |
| 70 | negative regulation of neurotransmitter transport (GO:0051589) | 3.22198454 |
| 71 | adaptation of signaling pathway (GO:0023058) | 3.21033518 |
| 72 | behavioral response to nicotine (GO:0035095) | 3.18154210 |
| 73 | positive regulation of meiosis (GO:0045836) | 3.17546463 |
| 74 | nucleoside diphosphate phosphorylation (GO:0006165) | 3.15296379 |
| 75 | cellular component assembly involved in morphogenesis (GO:0010927) | 3.13436234 |
| 76 | multicellular organismal development (GO:0007275) | 3.13434492 |
| 77 | glycerol ether metabolic process (GO:0006662) | 3.12540318 |
| 78 | ubiquinone metabolic process (GO:0006743) | 3.09707154 |
| 79 | indole-containing compound metabolic process (GO:0042430) | 3.08460498 |
| 80 | reflex (GO:0060004) | 3.00796487 |
| 81 | protein refolding (GO:0042026) | 2.99500671 |
| 82 | positive regulation of meiotic cell cycle (GO:0051446) | 2.98828181 |
| 83 | chromosome condensation (GO:0030261) | 2.97785634 |
| 84 | negative regulation of organelle assembly (GO:1902116) | 2.97538589 |
| 85 | ether metabolic process (GO:0018904) | 2.95735699 |
| 86 | gene silencing by RNA (GO:0031047) | 2.95733829 |
| 87 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.94659373 |
| 88 | detection of light stimulus involved in visual perception (GO:0050908) | 2.94659373 |
| 89 | polyol catabolic process (GO:0046174) | 2.94614038 |
| 90 | regulation of meiosis I (GO:0060631) | 2.93781044 |
| 91 | DNA packaging (GO:0006323) | 2.88298883 |
| 92 | gamma-aminobutyric acid transport (GO:0015812) | 2.87820662 |
| 93 | meiotic cell cycle process (GO:1903046) | 2.87209166 |
| 94 | regulation of glucocorticoid secretion (GO:2000849) | 2.83796426 |
| 95 | cell projection assembly (GO:0030031) | 2.82663689 |
| 96 | brain morphogenesis (GO:0048854) | 2.80985384 |
| 97 | protein K11-linked deubiquitination (GO:0035871) | 2.80957532 |
| 98 | adenosine metabolic process (GO:0046085) | 2.79545808 |
| 99 | signal peptide processing (GO:0006465) | 2.76581473 |
| 100 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 2.75694314 |
| 101 | carnitine transport (GO:0015879) | 2.71863843 |
| 102 | amino-acid betaine transport (GO:0015838) | 2.71863843 |
| 103 | transmission of nerve impulse (GO:0019226) | 2.70990923 |
| 104 | ubiquinone biosynthetic process (GO:0006744) | 2.70062658 |
| 105 | lactate metabolic process (GO:0006089) | 2.68493053 |
| 106 | left/right axis specification (GO:0070986) | 2.66864388 |
| 107 | microtubule polymerization or depolymerization (GO:0031109) | 2.66751890 |
| 108 | estrogen biosynthetic process (GO:0006703) | 2.66597547 |
| 109 | catecholamine transport (GO:0051937) | 2.66064601 |
| 110 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 2.66041993 |
| 111 | centriole replication (GO:0007099) | 2.65770805 |
| 112 | regulation of centriole replication (GO:0046599) | 2.65515952 |
| 113 | synapsis (GO:0007129) | 2.65354167 |
| 114 | centriole assembly (GO:0098534) | 2.65006146 |
| 115 | appendage development (GO:0048736) | 2.64838673 |
| 116 | limb development (GO:0060173) | 2.64838673 |
| 117 | carnitine transmembrane transport (GO:1902603) | 2.64005991 |
| 118 | protein-chromophore linkage (GO:0018298) | 2.60906582 |
| 119 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.60792700 |
| 120 | alditol metabolic process (GO:0019400) | 2.60302480 |
| 121 | regulation of spindle checkpoint (GO:0090231) | 2.59028109 |
| 122 | single strand break repair (GO:0000012) | 2.58643122 |
| 123 | photoreceptor cell development (GO:0042461) | 2.57487608 |
| 124 | smoothened signaling pathway (GO:0007224) | 2.55663380 |
| 125 | aldehyde catabolic process (GO:0046185) | 2.55287566 |
| 126 | negative regulation of reactive oxygen species metabolic process (GO:2000378) | 2.54544128 |
| 127 | microtubule bundle formation (GO:0001578) | 2.53028435 |
| 128 | GTP biosynthetic process (GO:0006183) | 2.49528625 |
| 129 | nucleus organization (GO:0006997) | 2.49515307 |
| 130 | diterpenoid biosynthetic process (GO:0016102) | 2.49364884 |
| 131 | negative regulation of systemic arterial blood pressure (GO:0003085) | 2.48435177 |
| 132 | quinone biosynthetic process (GO:1901663) | 2.46822041 |
| 133 | gonadal mesoderm development (GO:0007506) | 2.46761619 |
| 134 | resolution of meiotic recombination intermediates (GO:0000712) | 2.45964080 |
| 135 | platelet dense granule organization (GO:0060155) | 2.45268921 |
| 136 | establishment of protein localization to Golgi (GO:0072600) | 2.44711770 |
| 137 | dermatan sulfate biosynthetic process (GO:0030208) | 2.43772233 |
| 138 | glycolytic process (GO:0006096) | 2.43666969 |
| 139 | one-carbon compound transport (GO:0019755) | 2.43293845 |
| 140 | sexual reproduction (GO:0019953) | 2.43022282 |
| 141 | membrane depolarization during action potential (GO:0086010) | 2.41234858 |
| 142 | peptidyl-glutamic acid modification (GO:0018200) | 2.40800501 |
| 143 | cellular ketone body metabolic process (GO:0046950) | 2.40108215 |
| 144 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 2.38664529 |
| 145 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.38341477 |
| 146 | peptidyl-threonine dephosphorylation (GO:0035970) | 2.38253283 |
| 147 | determination of left/right symmetry (GO:0007368) | 2.38034731 |
| 148 | striatum development (GO:0021756) | 2.37328360 |
| 149 | proline transport (GO:0015824) | 2.35551089 |
| 150 | negative regulation of circadian rhythm (GO:0042754) | 2.35298918 |
| 151 | startle response (GO:0001964) | 2.35057052 |
| 152 | calcium ion import (GO:0070509) | 2.32273790 |
| 153 | glycerol metabolic process (GO:0006071) | 2.31275521 |
| 154 | regulation of cilium assembly (GO:1902017) | 2.30550612 |
| 155 | cilium or flagellum-dependent cell motility (GO:0001539) | 12.4058713 |
| 156 | fusion of sperm to egg plasma membrane (GO:0007342) | 12.0433708 |
| 157 | sperm motility (GO:0030317) | 10.8828566 |
| 158 | cell wall macromolecule catabolic process (GO:0016998) | 10.8128892 |
| 159 | cell wall macromolecule metabolic process (GO:0044036) | 10.8128892 |
| 160 | axonemal dynein complex assembly (GO:0070286) | 10.5641835 |
| 161 | acrosome assembly (GO:0001675) | 10.2444018 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 8.29531892 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.63075522 |
| 3 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.03611102 |
| 4 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.37386599 |
| 5 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.16615960 |
| 6 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.61472847 |
| 7 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.37193720 |
| 8 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.36987664 |
| 9 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.35896205 |
| 10 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.30070939 |
| 11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.23764467 |
| 12 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.09917422 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.06210875 |
| 14 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.05690372 |
| 15 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.99825738 |
| 16 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.95028479 |
| 17 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.94919346 |
| 18 | P300_19829295_ChIP-Seq_ESCs_Human | 1.94657897 |
| 19 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.93120122 |
| 20 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 1.92495937 |
| 21 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.89813046 |
| 22 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.88234767 |
| 23 | EWS_26573619_Chip-Seq_HEK293_Human | 1.84135249 |
| 24 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.83245764 |
| 25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.79285815 |
| 26 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.78741672 |
| 27 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.74584232 |
| 28 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.69919811 |
| 29 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.69509277 |
| 30 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.68878128 |
| 31 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.65918264 |
| 32 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.65368624 |
| 33 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.62988629 |
| 34 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.59019260 |
| 35 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.58957427 |
| 36 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.51663154 |
| 37 | AR_25329375_ChIP-Seq_VCAP_Human | 1.51643771 |
| 38 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.50916859 |
| 39 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.49460681 |
| 40 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.48048758 |
| 41 | KDM2B_26808549_Chip-Seq_REH_Human | 1.46547247 |
| 42 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.46285889 |
| 43 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.45387021 |
| 44 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.45075209 |
| 45 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.44035235 |
| 46 | * IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.43315157 |
| 47 | * CBP_20019798_ChIP-Seq_JUKART_Human | 1.43315157 |
| 48 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.42682530 |
| 49 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.42621375 |
| 50 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.40844353 |
| 51 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.37425250 |
| 52 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.35959532 |
| 53 | STAT1_17558387_ChIP-Seq_HELA_Human | 1.35575774 |
| 54 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.34360113 |
| 55 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.33998300 |
| 56 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.32574035 |
| 57 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.30983079 |
| 58 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.30983079 |
| 59 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.30445990 |
| 60 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.29800639 |
| 61 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.29298431 |
| 62 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.28102732 |
| 63 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.26304825 |
| 64 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.25842994 |
| 65 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.25646728 |
| 66 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.25284255 |
| 67 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.25244176 |
| 68 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.25023648 |
| 69 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.24955497 |
| 70 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.23924718 |
| 71 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.23778134 |
| 72 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.23210707 |
| 73 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.22979390 |
| 74 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.22876144 |
| 75 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.22876144 |
| 76 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.21705584 |
| 77 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.21266333 |
| 78 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.20746604 |
| 79 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.20623591 |
| 80 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.18757658 |
| 81 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.18114624 |
| 82 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.17285941 |
| 83 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.17020217 |
| 84 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.15001151 |
| 85 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.13028682 |
| 86 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.11886609 |
| 87 | TBL1_22424771_ChIP-Seq_293T_Human | 1.11240442 |
| 88 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.11112487 |
| 89 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.10219363 |
| 90 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.09946009 |
| 91 | * TAF15_26573619_Chip-Seq_HEK293_Human | 1.08852574 |
| 92 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.08397054 |
| 93 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.07954776 |
| 94 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 1.07791525 |
| 95 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.07537409 |
| 96 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.07529371 |
| 97 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.07367933 |
| 98 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.07361282 |
| 99 | NFYB_21822215_ChIP-Seq_K562_Human | 1.06866988 |
| 100 | * FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.06429285 |
| 101 | * FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.06429285 |
| 102 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.06249122 |
| 103 | GF1_26923725_Chip-Seq_HPCs_Mouse | 1.04736474 |
| 104 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.03745321 |
| 105 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 1.03693530 |
| 106 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.03683059 |
| 107 | TCF4_23295773_ChIP-Seq_U87_Human | 1.03459338 |
| 108 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 1.03414577 |
| 109 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.03260009 |
| 110 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.03225818 |
| 111 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.03188823 |
| 112 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03036031 |
| 113 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.02890571 |
| 114 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.02887902 |
| 115 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.01902345 |
| 116 | NFYA_21822215_ChIP-Seq_K562_Human | 1.01893332 |
| 117 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.01872237 |
| 118 | NCOR_22424771_ChIP-Seq_293T_Human | 1.01701709 |
| 119 | RXR_22108803_ChIP-Seq_LS180_Human | 1.01363815 |
| 120 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.01267371 |
| 121 | CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.00782668 |
| 122 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.00245927 |
| 123 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.00105664 |
| 124 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 0.98340154 |
| 125 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 0.98150536 |
| 126 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.98008141 |
| 127 | FUS_26573619_Chip-Seq_HEK293_Human | 0.97884171 |
| 128 | GF1B_26923725_Chip-Seq_HPCs_Mouse | 0.95930027 |
| 129 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 0.95896030 |
| 130 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.95760794 |
| 131 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.95399167 |
| 132 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.94596283 |
| 133 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 0.93797622 |
| 134 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.93660784 |
| 135 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.93032297 |
| 136 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 0.92428344 |
| 137 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.92390672 |
| 138 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.92174824 |
| 139 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.91675523 |
| 140 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.90487485 |
| 141 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.89778565 |
| 142 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.89613970 |
| 143 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.89359230 |
| 144 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.88456924 |
| 145 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.88330379 |
| 146 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.87901971 |
| 147 | STAT3_23295773_ChIP-Seq_U87_Human | 0.87568507 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003698_abnormal_male_reproductive | 5.23648225 |
| 2 | MP0001929_abnormal_gametogenesis | 4.71472841 |
| 3 | MP0008877_abnormal_DNA_methylation | 4.35093057 |
| 4 | MP0002638_abnormal_pupillary_reflex | 3.91819122 |
| 5 | MP0002653_abnormal_ependyma_morphology | 3.37583996 |
| 6 | MP0002210_abnormal_sex_determination | 3.16447817 |
| 7 | MP0003136_yellow_coat_color | 3.15417721 |
| 8 | MP0002161_abnormal_fertility/fecundity | 2.89902250 |
| 9 | MP0003195_calcinosis | 2.74420828 |
| 10 | MP0001145_abnormal_male_reproductive | 2.68879743 |
| 11 | MP0001984_abnormal_olfaction | 2.51823056 |
| 12 | MP0000653_abnormal_sex_gland | 2.39754340 |
| 13 | MP0000383_abnormal_hair_follicle | 2.34997516 |
| 14 | MP0005623_abnormal_meninges_morphology | 2.29866968 |
| 15 | MP0000427_abnormal_hair_cycle | 2.20636113 |
| 16 | MP0009046_muscle_twitch | 2.13213993 |
| 17 | MP0004859_abnormal_synaptic_plasticity | 2.00191351 |
| 18 | MP0005410_abnormal_fertilization | 12.9146768 |
| 19 | MP0002876_abnormal_thyroid_physiology | 1.97218517 |
| 20 | MP0002160_abnormal_reproductive_system | 1.90379993 |
| 21 | MP0003183_abnormal_peptide_metabolism | 1.86439830 |
| 22 | MP0004233_abnormal_muscle_weight | 1.74927937 |
| 23 | MP0003880_abnormal_central_pattern | 1.72478444 |
| 24 | MP0008875_abnormal_xenobiotic_pharmacok | 1.66805114 |
| 25 | MP0010678_abnormal_skin_adnexa | 1.66210158 |
| 26 | MP0010386_abnormal_urinary_bladder | 1.64938269 |
| 27 | MP0003635_abnormal_synaptic_transmissio | 1.55849424 |
| 28 | MP0001485_abnormal_pinna_reflex | 1.51007144 |
| 29 | MP0003646_muscle_fatigue | 1.46282330 |
| 30 | MP0004270_analgesia | 1.44029876 |
| 31 | MP0002102_abnormal_ear_morphology | 1.42990539 |
| 32 | MP0001905_abnormal_dopamine_level | 1.39567406 |
| 33 | MP0004043_abnormal_pH_regulation | 1.36379138 |
| 34 | MP0008872_abnormal_physiological_respon | 1.35286686 |
| 35 | MP0001968_abnormal_touch/_nociception | 1.34911139 |
| 36 | MP0003890_abnormal_embryonic-extraembry | 1.33945009 |
| 37 | MP0009780_abnormal_chondrocyte_physiolo | 1.31625930 |
| 38 | MP0002063_abnormal_learning/memory/cond | 1.29642131 |
| 39 | MP0003718_maternal_effect | 1.23628726 |
| 40 | MP0005174_abnormal_tail_pigmentation | 1.22049718 |
| 41 | MP0003329_amyloid_beta_deposits | 1.19513628 |
| 42 | MP0005670_abnormal_white_adipose | 1.19202490 |
| 43 | MP0002572_abnormal_emotion/affect_behav | 1.16788884 |
| 44 | MP0005379_endocrine/exocrine_gland_phen | 1.16571313 |
| 45 | MP0002282_abnormal_trachea_morphology | 1.16158304 |
| 46 | MP0002734_abnormal_mechanical_nocicepti | 1.15369080 |
| 47 | MP0002736_abnormal_nociception_after | 1.14440597 |
| 48 | MP0004885_abnormal_endolymph | 1.14365060 |
| 49 | MP0000015_abnormal_ear_pigmentation | 1.13717677 |
| 50 | MP0009745_abnormal_behavioral_response | 1.13595409 |
| 51 | MP0005645_abnormal_hypothalamus_physiol | 1.12755807 |
| 52 | MP0005423_abnormal_somatic_nervous | 1.11807061 |
| 53 | MP0002064_seizures | 1.09877355 |
| 54 | MP0005389_reproductive_system_phenotype | 1.05366064 |
| 55 | MP0002234_abnormal_pharynx_morphology | 1.04892637 |
| 56 | MP0003950_abnormal_plasma_membrane | 1.04586069 |
| 57 | MP0001664_abnormal_digestion | 1.03715059 |
| 58 | MP0002163_abnormal_gland_morphology | 1.03539250 |
| 59 | MP0001440_abnormal_grooming_behavior | 1.00668852 |
| 60 | MP0003879_abnormal_hair_cell | 0.99422104 |
| 61 | MP0001986_abnormal_taste_sensitivity | 0.95878734 |
| 62 | MP0001486_abnormal_startle_reflex | 0.95849441 |
| 63 | MP0000778_abnormal_nervous_system | 0.95680985 |
| 64 | MP0003878_abnormal_ear_physiology | 0.95660869 |
| 65 | MP0005377_hearing/vestibular/ear_phenot | 0.95660869 |
| 66 | MP0005394_taste/olfaction_phenotype | 0.94231093 |
| 67 | MP0005499_abnormal_olfactory_system | 0.94231093 |
| 68 | MP0002272_abnormal_nervous_system | 0.94224414 |
| 69 | MP0004811_abnormal_neuron_physiology | 0.93149630 |
| 70 | MP0004085_abnormal_heartbeat | 0.93067657 |
| 71 | MP0000569_abnormal_digit_pigmentation | 0.92424265 |
| 72 | MP0008995_early_reproductive_senescence | 0.92296337 |
| 73 | MP0005083_abnormal_biliary_tract | 0.90097948 |
| 74 | MP0002735_abnormal_chemical_nociception | 0.89120768 |
| 75 | MP0005085_abnormal_gallbladder_physiolo | 0.88629857 |
| 76 | MP0001765_abnormal_ion_homeostasis | 0.88475534 |
| 77 | MP0002557_abnormal_social/conspecific_i | 0.88300929 |
| 78 | MP0005551_abnormal_eye_electrophysiolog | 0.87203274 |
| 79 | MP0005395_other_phenotype | 0.85370254 |
| 80 | MP0004019_abnormal_vitamin_homeostasis | 0.82327009 |
| 81 | MP0008789_abnormal_olfactory_epithelium | 0.82098158 |
| 82 | MP0002152_abnormal_brain_morphology | 0.80653226 |
| 83 | MP0000372_irregular_coat_pigmentation | 0.80199513 |
| 84 | MP0002095_abnormal_skin_pigmentation | 0.79699638 |
| 85 | MP0002184_abnormal_innervation | 0.79583467 |
| 86 | MP0008058_abnormal_DNA_repair | 0.79198621 |
| 87 | MP0002168_other_aberrant_phenotype | 0.79107768 |
| 88 | MP0003943_abnormal_hepatobiliary_system | 0.78631816 |
| 89 | MP0002067_abnormal_sensory_capabilities | 0.78386706 |
| 90 | MP0006276_abnormal_autonomic_nervous | 0.77928263 |
| 91 | MP0002693_abnormal_pancreas_physiology | 0.77192970 |
| 92 | MP0005535_abnormal_body_temperature | 0.76197673 |
| 93 | MP0000955_abnormal_spinal_cord | 0.75752523 |
| 94 | MP0001764_abnormal_homeostasis | 0.75475307 |
| 95 | MP0003115_abnormal_respiratory_system | 0.74772007 |
| 96 | MP0005647_abnormal_sex_gland | 0.74292638 |
| 97 | MP0003861_abnormal_nervous_system | 0.73281791 |
| 98 | MP0002882_abnormal_neuron_morphology | 0.71057614 |
| 99 | MP0002909_abnormal_adrenal_gland | 0.62882239 |
| 100 | MP0004133_heterotaxia | 0.61806484 |
| 101 | MP0002733_abnormal_thermal_nociception | 0.60289354 |
| 102 | MP0004742_abnormal_vestibular_system | 0.59953590 |
| 103 | MP0005646_abnormal_pituitary_gland | 0.59505984 |
| 104 | MP0005253_abnormal_eye_physiology | 0.59090391 |
| 105 | MP0008057_abnormal_DNA_replication | 0.58669417 |
| 106 | MP0002066_abnormal_motor_capabilities/c | 0.57839141 |
| 107 | MP0002752_abnormal_somatic_nervous | 0.57510769 |
| 108 | MP0001970_abnormal_pain_threshold | 0.56586856 |
| 109 | MP0000534_abnormal_ureter_morphology | 0.54661491 |
| 110 | MP0006072_abnormal_retinal_apoptosis | 0.54648625 |
| 111 | MP0000358_abnormal_cell_content/ | 0.52044125 |
| 112 | MP0002229_neurodegeneration | 0.51440138 |
| 113 | MP0001529_abnormal_vocalization | 0.50979744 |
| 114 | MP0008569_lethality_at_weaning | 0.50901179 |
| 115 | MP0001502_abnormal_circadian_rhythm | 0.50664312 |
| 116 | MP0003699_abnormal_female_reproductive | 0.49107778 |
| 117 | MP0002928_abnormal_bile_duct | 0.49096276 |
| 118 | MP0003633_abnormal_nervous_system | 0.48983459 |
| 119 | MP0001501_abnormal_sleep_pattern | 0.48010089 |
| 120 | MP0001293_anophthalmia | 0.47195423 |
| 121 | MP0003942_abnormal_urinary_system | 0.46060245 |
| 122 | MP0003631_nervous_system_phenotype | 0.45488333 |
| 123 | MP0003787_abnormal_imprinting | 0.45369309 |
| 124 | MP0004036_abnormal_muscle_relaxation | 0.45352578 |
| 125 | MP0001324_abnormal_eye_pigmentation | 0.44554744 |
| 126 | MP0005391_vision/eye_phenotype | 0.43612811 |
| 127 | MP0004924_abnormal_behavior | 0.43393122 |
| 128 | MP0005386_behavior/neurological_phenoty | 0.43393122 |
| 129 | MP0003634_abnormal_glial_cell | 0.43384678 |
| 130 | MP0004145_abnormal_muscle_electrophysio | 0.43147796 |
| 131 | MP0001963_abnormal_hearing_physiology | 0.43105012 |
| 132 | MP0003122_maternal_imprinting | 0.42252672 |
| 133 | MP0005195_abnormal_posterior_eye | 0.40630164 |
| 134 | MP0000604_amyloidosis | 0.39681424 |
| 135 | MP0005187_abnormal_penis_morphology | 0.39533563 |
| 136 | MP0002295_abnormal_pulmonary_circulatio | 0.38865710 |
| 137 | MP0000631_abnormal_neuroendocrine_gland | 0.38843410 |
| 138 | MP0003786_premature_aging | 0.38328469 |
| 139 | MP0000026_abnormal_inner_ear | 0.38031042 |
| 140 | MP0010094_abnormal_chromosome_stability | 0.37927173 |
| 141 | MP0001299_abnormal_eye_distance/ | 0.37817385 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal respiratory motile cilium physiology (HP:0012261) | 9.58726601 |
| 2 | Abnormal respiratory epithelium morphology (HP:0012253) | 8.68486335 |
| 3 | Abnormal respiratory motile cilium morphology (HP:0005938) | 8.68486335 |
| 4 | Abnormal ciliary motility (HP:0012262) | 8.13552658 |
| 5 | Rhinitis (HP:0012384) | 7.79344849 |
| 6 | Chronic bronchitis (HP:0004469) | 6.79207802 |
| 7 | Infertility (HP:0000789) | 5.91312296 |
| 8 | Nasal polyposis (HP:0100582) | 5.17232071 |
| 9 | Bronchiectasis (HP:0002110) | 4.42209031 |
| 10 | Nephronophthisis (HP:0000090) | 4.38623784 |
| 11 | Abnormality of the nasal mucosa (HP:0000433) | 4.14118395 |
| 12 | Bronchitis (HP:0012387) | 3.70579130 |
| 13 | Attenuation of retinal blood vessels (HP:0007843) | 3.54433105 |
| 14 | Male infertility (HP:0003251) | 3.43634406 |
| 15 | Abnormality of the renal medulla (HP:0100957) | 3.29139557 |
| 16 | Hyperventilation (HP:0002883) | 3.28468694 |
| 17 | Medial flaring of the eyebrow (HP:0010747) | 3.24214544 |
| 18 | Abnormality of macular pigmentation (HP:0008002) | 3.17541167 |
| 19 | Abnormality of midbrain morphology (HP:0002418) | 3.09498044 |
| 20 | Molar tooth sign on MRI (HP:0002419) | 3.09498044 |
| 21 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.94396865 |
| 22 | Abnormality of the lower motor neuron (HP:0002366) | 2.87619574 |
| 23 | Diastasis recti (HP:0001540) | 2.78881088 |
| 24 | Cone-rod dystrophy (HP:0000548) | 2.74753987 |
| 25 | Recurrent otitis media (HP:0000403) | 2.72307090 |
| 26 | Recurrent sinusitis (HP:0011108) | 2.71214041 |
| 27 | Tubulointerstitial nephritis (HP:0001970) | 2.68922208 |
| 28 | Abnormal spermatogenesis (HP:0008669) | 2.66491998 |
| 29 | Volvulus (HP:0002580) | 2.58849642 |
| 30 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.54510739 |
| 31 | Tubular atrophy (HP:0000092) | 2.54431392 |
| 32 | Gait imbalance (HP:0002141) | 2.46659244 |
| 33 | Type II lissencephaly (HP:0007260) | 2.41593177 |
| 34 | Abolished electroretinogram (ERG) (HP:0000550) | 2.39298822 |
| 35 | Limb dystonia (HP:0002451) | 2.35086402 |
| 36 | Congenital primary aphakia (HP:0007707) | 2.33099123 |
| 37 | Amyotrophic lateral sclerosis (HP:0007354) | 2.30852156 |
| 38 | Congenital stationary night blindness (HP:0007642) | 2.30173334 |
| 39 | Decreased circulating renin level (HP:0003351) | 2.29484615 |
| 40 | Sclerocornea (HP:0000647) | 2.28845114 |
| 41 | Constricted visual fields (HP:0001133) | 2.28254333 |
| 42 | Tubulointerstitial abnormality (HP:0001969) | 2.28115573 |
| 43 | Gonadotropin excess (HP:0000837) | 2.22539446 |
| 44 | Congenital sensorineural hearing impairment (HP:0008527) | 2.18547681 |
| 45 | Widely spaced teeth (HP:0000687) | 2.17617944 |
| 46 | Febrile seizures (HP:0002373) | 2.16128628 |
| 47 | Pancreatic fibrosis (HP:0100732) | 2.13543703 |
| 48 | Retinitis pigmentosa (HP:0000510) | 2.13319626 |
| 49 | Hypothermia (HP:0002045) | 2.12986312 |
| 50 | Bifid tongue (HP:0010297) | 2.06384348 |
| 51 | Postaxial foot polydactyly (HP:0001830) | 2.04380241 |
| 52 | Prominent nasal bridge (HP:0000426) | 2.02828596 |
| 53 | Impulsivity (HP:0100710) | 2.02451926 |
| 54 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.02414285 |
| 55 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.02414285 |
| 56 | Abnormal protein glycosylation (HP:0012346) | 2.02414285 |
| 57 | Abnormal glycosylation (HP:0012345) | 2.02414285 |
| 58 | Azoospermia (HP:0000027) | 2.02196216 |
| 59 | Nephrogenic diabetes insipidus (HP:0009806) | 2.01032852 |
| 60 | Absent speech (HP:0001344) | 2.00565897 |
| 61 | Fibular hypoplasia (HP:0003038) | 2.00289747 |
| 62 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.00038672 |
| 63 | Hypoplasia of the fovea (HP:0007750) | 2.00038672 |
| 64 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 12.6243204 |
| 65 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 11.5483877 |
| 66 | Absent/shortened dynein arms (HP:0200106) | 11.5483877 |
| 67 | Increased corneal curvature (HP:0100692) | 1.99440379 |
| 68 | Keratoconus (HP:0000563) | 1.99440379 |
| 69 | Small hand (HP:0200055) | 1.97230106 |
| 70 | Congenital hepatic fibrosis (HP:0002612) | 1.95615157 |
| 71 | Postaxial hand polydactyly (HP:0001162) | 1.94673989 |
| 72 | Polyuria (HP:0000103) | 1.93378773 |
| 73 | Stage 5 chronic kidney disease (HP:0003774) | 1.92697766 |
| 74 | Abnormality of dentin (HP:0010299) | 1.89312029 |
| 75 | Anencephaly (HP:0002323) | 1.89035625 |
| 76 | Oculomotor apraxia (HP:0000657) | 1.87910501 |
| 77 | Mesangial abnormality (HP:0001966) | 1.87741446 |
| 78 | Tubulointerstitial fibrosis (HP:0005576) | 1.86024567 |
| 79 | Cerebellar dysplasia (HP:0007033) | 1.83795360 |
| 80 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.83734920 |
| 81 | Microretrognathia (HP:0000308) | 1.83006685 |
| 82 | Male pseudohermaphroditism (HP:0000037) | 1.82288551 |
| 83 | Protruding tongue (HP:0010808) | 1.81544832 |
| 84 | Microglossia (HP:0000171) | 1.80922265 |
| 85 | Abnormality of permanent molar morphology (HP:0011071) | 1.80786901 |
| 86 | Abnormality of the dental root (HP:0006486) | 1.80786901 |
| 87 | Taurodontia (HP:0000679) | 1.80786901 |
| 88 | Genital tract atresia (HP:0001827) | 1.80410560 |
| 89 | Facial cleft (HP:0002006) | 1.79193500 |
| 90 | Vaginal atresia (HP:0000148) | 1.77915405 |
| 91 | Short foot (HP:0001773) | 1.77227323 |
| 92 | Poor coordination (HP:0002370) | 1.76222066 |
| 93 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.75341818 |
| 94 | Multicystic kidney dysplasia (HP:0000003) | 1.75025358 |
| 95 | Furrowed tongue (HP:0000221) | 1.74724454 |
| 96 | Highly arched eyebrow (HP:0002553) | 1.74634571 |
| 97 | Preaxial hand polydactyly (HP:0001177) | 1.74562422 |
| 98 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.74155912 |
| 99 | Nephrotic syndrome (HP:0000100) | 1.73928206 |
| 100 | Congenital, generalized hypertrichosis (HP:0004540) | 1.73921549 |
| 101 | Chronic sinusitis (HP:0011109) | 1.73812267 |
| 102 | Supernumerary spleens (HP:0009799) | 1.73163368 |
| 103 | Abnormality of the fovea (HP:0000493) | 1.68970679 |
| 104 | Cystic liver disease (HP:0006706) | 1.68179792 |
| 105 | Abnormality of molar (HP:0011077) | 1.67694815 |
| 106 | Abnormality of molar morphology (HP:0011070) | 1.67694815 |
| 107 | Specific learning disability (HP:0001328) | 1.67624917 |
| 108 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.65082655 |
| 109 | Recurrent bronchitis (HP:0002837) | 1.64826682 |
| 110 | Abnormality of the dental pulp (HP:0006479) | 1.64383872 |
| 111 | Short ribs (HP:0000773) | 1.63715614 |
| 112 | Abnormal drinking behavior (HP:0030082) | 1.62992256 |
| 113 | Polydipsia (HP:0001959) | 1.62992256 |
| 114 | True hermaphroditism (HP:0010459) | 1.60983195 |
| 115 | Median cleft lip (HP:0000161) | 1.60168089 |
| 116 | Progressive cerebellar ataxia (HP:0002073) | 1.55730376 |
| 117 | Dyschromatopsia (HP:0007641) | 1.50546718 |
| 118 | Renal dysplasia (HP:0000110) | 1.47929401 |
| 119 | Abnormal gallbladder physiology (HP:0012438) | 1.47491819 |
| 120 | Cholecystitis (HP:0001082) | 1.47491819 |
| 121 | Bell-shaped thorax (HP:0001591) | 1.46827841 |
| 122 | Abnormality of saccadic eye movements (HP:0000570) | 1.45105745 |
| 123 | Heterotopia (HP:0002282) | 1.44467929 |
| 124 | Spastic tetraparesis (HP:0001285) | 1.42492602 |
| 125 | Pancreatic cysts (HP:0001737) | 1.42220182 |
| 126 | Impaired smooth pursuit (HP:0007772) | 1.42102965 |
| 127 | Abnormality of the renal cortex (HP:0011035) | 1.41636024 |
| 128 | Occipital encephalocele (HP:0002085) | 1.38457900 |
| 129 | Aplasia/Hypoplasia of the fibula (HP:0006492) | 1.37436356 |
| 130 | Decreased central vision (HP:0007663) | 1.37410426 |
| 131 | Hemiparesis (HP:0001269) | 1.37164745 |
| 132 | Retinal dysplasia (HP:0007973) | 1.36613433 |
| 133 | Gaze-evoked nystagmus (HP:0000640) | 1.36179464 |
| 134 | Chronic hepatic failure (HP:0100626) | 1.35137859 |
| 135 | Abnormality of renal excretion (HP:0011036) | 1.34994463 |
| 136 | Abnormal biliary tract physiology (HP:0012439) | 1.34023511 |
| 137 | Bile duct proliferation (HP:0001408) | 1.34023511 |
| 138 | Choroideremia (HP:0001139) | 1.33595450 |
| 139 | Focal motor seizures (HP:0011153) | 1.33085100 |
| 140 | Neurofibrillary tangles (HP:0002185) | 1.30910293 |
| 141 | Impaired proprioception (HP:0010831) | 1.30085266 |
| 142 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.28507014 |
| 143 | Focal seizures (HP:0007359) | 1.28430456 |
| 144 | Cerebral inclusion bodies (HP:0100314) | 1.27064014 |
| 145 | Broad distal phalanx of finger (HP:0009836) | 1.25852435 |
| 146 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.25465371 |
| 147 | Absent epiphyses (HP:0010577) | 1.25465371 |
| 148 | Epileptic encephalopathy (HP:0200134) | 1.24175521 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PDK4 | 8.06512004 |
| 2 | PDK3 | 8.06512004 |
| 3 | INSRR | 5.46130927 |
| 4 | PDK2 | 5.18353349 |
| 5 | FRK | 4.49780486 |
| 6 | TESK1 | 4.41618864 |
| 7 | PRKD3 | 4.13891730 |
| 8 | PNCK | 3.24624205 |
| 9 | NUAK1 | 3.16877762 |
| 10 | ICK | 3.16245728 |
| 11 | PTK2B | 2.38112930 |
| 12 | ACVR1B | 1.96209768 |
| 13 | PIK3CG | 1.88082183 |
| 14 | STK38 | 1.87803789 |
| 15 | ADRBK2 | 1.84272161 |
| 16 | CAMKK2 | 1.81957410 |
| 17 | WNK4 | 1.79886167 |
| 18 | STK39 | 1.77102184 |
| 19 | BMPR1B | 1.66362907 |
| 20 | MST4 | 1.57157808 |
| 21 | MAP3K12 | 1.52530746 |
| 22 | MAP4K2 | 1.48769893 |
| 23 | GRK1 | 1.45028730 |
| 24 | NEK2 | 1.44522689 |
| 25 | EIF2AK3 | 1.43835264 |
| 26 | CSNK1G2 | 1.40585146 |
| 27 | CSNK1G3 | 1.31194796 |
| 28 | MARK1 | 1.30004504 |
| 29 | KIT | 1.29080015 |
| 30 | CCNB1 | 1.28330758 |
| 31 | MAP3K4 | 1.23037360 |
| 32 | MET | 1.16404655 |
| 33 | MAPK15 | 1.11394800 |
| 34 | CDK19 | 1.10935800 |
| 35 | NTRK2 | 1.10849419 |
| 36 | CSNK1G1 | 1.08929947 |
| 37 | TYRO3 | 1.07532273 |
| 38 | MAP2K7 | 1.06246350 |
| 39 | MAP3K9 | 1.05267194 |
| 40 | TLK1 | 1.03949861 |
| 41 | ADRBK1 | 1.01468943 |
| 42 | NTRK3 | 0.94075688 |
| 43 | LATS2 | 0.92735490 |
| 44 | PRKCE | 0.90817726 |
| 45 | MINK1 | 0.89438563 |
| 46 | MAPKAPK3 | 0.88319616 |
| 47 | STK38L | 0.87291016 |
| 48 | PDK1 | 0.86806886 |
| 49 | EPHA4 | 0.81793776 |
| 50 | WEE1 | 0.75157340 |
| 51 | LMTK2 | 0.74830775 |
| 52 | SGK2 | 0.74658632 |
| 53 | DYRK1B | 0.73406543 |
| 54 | FGFR2 | 0.73360780 |
| 55 | PAK6 | 0.73014207 |
| 56 | WNK1 | 0.71395177 |
| 57 | MAP3K7 | 0.71362938 |
| 58 | CAMK1 | 0.71031901 |
| 59 | STK3 | 0.70553582 |
| 60 | PRKCG | 0.67847130 |
| 61 | PLK2 | 0.66390090 |
| 62 | MAP2K4 | 0.66304485 |
| 63 | TTK | 0.64066169 |
| 64 | MAP3K2 | 0.63690203 |
| 65 | CAMK1G | 0.61949407 |
| 66 | NME1 | 0.61632735 |
| 67 | ZAK | 0.60175170 |
| 68 | TXK | 0.59341363 |
| 69 | PLK4 | 0.59303131 |
| 70 | TEC | 0.58668890 |
| 71 | CAMKK1 | 0.56987476 |
| 72 | CHEK2 | 0.55601680 |
| 73 | TSSK6 | 0.51935316 |
| 74 | STK16 | 0.51223754 |
| 75 | DAPK2 | 0.50071768 |
| 76 | CASK | 0.49275235 |
| 77 | BRSK1 | 0.49065119 |
| 78 | DYRK3 | 0.48175238 |
| 79 | PINK1 | 0.47789851 |
| 80 | RIPK4 | 0.47384015 |
| 81 | TGFBR1 | 0.47359317 |
| 82 | PDPK1 | 0.46184512 |
| 83 | TNIK | 0.45164300 |
| 84 | IRAK1 | 0.44585641 |
| 85 | WNK3 | 0.43932465 |
| 86 | VRK1 | 0.39642915 |
| 87 | AKT3 | 0.39455516 |
| 88 | MAPKAPK5 | 0.38401469 |
| 89 | PIK3CA | 0.37407026 |
| 90 | BRAF | 0.37110536 |
| 91 | MARK2 | 0.36899107 |
| 92 | TAOK3 | 0.36848658 |
| 93 | PRKCI | 0.36650026 |
| 94 | PRKACA | 0.35376305 |
| 95 | CHEK1 | 0.35256110 |
| 96 | MYLK | 0.35189040 |
| 97 | GRK5 | 0.34830691 |
| 98 | BCR | 0.34488186 |
| 99 | PASK | 0.33595308 |
| 100 | CSNK1A1 | 0.33298060 |
| 101 | LATS1 | 0.32471508 |
| 102 | PRKG1 | 0.32346042 |
| 103 | STK11 | 0.31997095 |
| 104 | CDK5 | 0.31891634 |
| 105 | GRK7 | 0.30551806 |
| 106 | MAP2K6 | 0.30411844 |
| 107 | CDK18 | 0.30259791 |
| 108 | SGK494 | 0.30079236 |
| 109 | SGK223 | 0.30079236 |
| 110 | BRSK2 | 0.30054848 |
| 111 | CDC7 | 0.29862390 |
| 112 | CDK15 | 0.29550050 |
| 113 | CAMK2A | 0.29335260 |
| 114 | PAK1 | 0.28450115 |
| 115 | CSNK1D | 0.28302758 |
| 116 | MAPK13 | 0.28274227 |
| 117 | CDK14 | 0.27978209 |
| 118 | PRKCQ | 0.27658380 |
| 119 | SGK1 | 0.27061287 |
| 120 | NTRK1 | 0.26911829 |
| 121 | PRKAA1 | 0.26861131 |
| 122 | TRIM28 | 0.26601627 |
| 123 | PAK3 | 0.26374799 |
| 124 | PLK1 | 0.26047113 |
| 125 | PRKCA | 0.25147959 |
| 126 | FER | 0.25091642 |
| 127 | PAK2 | 0.25073837 |
| 128 | ROCK1 | 0.23950218 |
| 129 | MAP2K1 | 0.23915279 |
| 130 | PLK3 | 0.22462839 |
| 131 | ATM | 0.22346826 |
| 132 | CDK3 | 0.22142884 |
| 133 | CDK11A | 0.21987290 |
| 134 | PRKCZ | 0.21162727 |
| 135 | MUSK | 0.20012266 |
| 136 | DAPK1 | 0.19843852 |
| 137 | NEK6 | 0.19605944 |
| 138 | MTOR | 0.19333968 |
| 139 | AURKA | 0.19244039 |
| 140 | TESK2 | 0.18925093 |
| 141 | PHKG2 | 0.18798475 |
| 142 | PHKG1 | 0.18798475 |
| 143 | MAPK10 | 0.17664692 |
| 144 | OXSR1 | 0.17408201 |
| 145 | ATR | 0.15214230 |
| 146 | ERBB3 | 0.14748735 |
| 147 | IRAK2 | 0.13948427 |
| 148 | GSK3B | 0.13082333 |
| 149 | RPS6KB1 | 0.13016646 |
| 150 | CSNK1E | 0.12928225 |
| 151 | DYRK2 | 0.12653961 |
| 152 | TAOK1 | 0.11799871 |
| 153 | KSR1 | 0.10678774 |
| 154 | KSR2 | 0.10523599 |
| 155 | MAP3K5 | 0.09444305 |
| 156 | RPS6KA3 | 0.08975319 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.99395628 |
| 2 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.84416401 |
| 3 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.80576266 |
| 4 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 2.75250508 |
| 5 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.51070225 |
| 6 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.51013291 |
| 7 | Circadian rhythm_Homo sapiens_hsa04710 | 2.50177917 |
| 8 | Oocyte meiosis_Homo sapiens_hsa04114 | 2.49879977 |
| 9 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.43169232 |
| 10 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.41841948 |
| 11 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.38100320 |
| 12 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 2.35442713 |
| 13 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.31673719 |
| 14 | Nicotine addiction_Homo sapiens_hsa05033 | 2.08678102 |
| 15 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 2.03817161 |
| 16 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.98301452 |
| 17 | Long-term potentiation_Homo sapiens_hsa04720 | 1.93454183 |
| 18 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.92223965 |
| 19 | Olfactory transduction_Homo sapiens_hsa04740 | 1.91398728 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.87061221 |
| 21 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.81465882 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.80208523 |
| 23 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.77203981 |
| 24 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.76710811 |
| 25 | Renin secretion_Homo sapiens_hsa04924 | 1.75518537 |
| 26 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.72159980 |
| 27 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.70436450 |
| 28 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.70008395 |
| 29 | Histidine metabolism_Homo sapiens_hsa00340 | 1.66652097 |
| 30 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.66526606 |
| 31 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.66475173 |
| 32 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.64699663 |
| 33 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.64380601 |
| 34 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.60347513 |
| 35 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.58975446 |
| 36 | ABC transporters_Homo sapiens_hsa02010 | 1.57714402 |
| 37 | Circadian entrainment_Homo sapiens_hsa04713 | 1.53394942 |
| 38 | Insulin secretion_Homo sapiens_hsa04911 | 1.50957559 |
| 39 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.50324383 |
| 40 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.50226362 |
| 41 | Taste transduction_Homo sapiens_hsa04742 | 1.46839672 |
| 42 | Huntingtons disease_Homo sapiens_hsa05016 | 1.46717348 |
| 43 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.43153007 |
| 44 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.41457835 |
| 45 | Protein export_Homo sapiens_hsa03060 | 1.41288634 |
| 46 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.36763632 |
| 47 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.35329396 |
| 48 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.35238579 |
| 49 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.34363823 |
| 50 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.34199335 |
| 51 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.33545867 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.32056346 |
| 53 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.31343953 |
| 54 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.30799153 |
| 55 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.29541819 |
| 56 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.29264053 |
| 57 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.28071839 |
| 58 | Salivary secretion_Homo sapiens_hsa04970 | 1.27040146 |
| 59 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.25987866 |
| 60 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.24371254 |
| 61 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.23652736 |
| 62 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.20825467 |
| 63 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.19363960 |
| 64 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.19098322 |
| 65 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.16024800 |
| 66 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.15639897 |
| 67 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.15601362 |
| 68 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.13174138 |
| 69 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.12560980 |
| 70 | Retinol metabolism_Homo sapiens_hsa00830 | 1.11653772 |
| 71 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.11075933 |
| 72 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.09692892 |
| 73 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.06891062 |
| 74 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.06483684 |
| 75 | Morphine addiction_Homo sapiens_hsa05032 | 1.05533015 |
| 76 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.05289895 |
| 77 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.05219739 |
| 78 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.02558206 |
| 79 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.01802006 |
| 80 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.01255425 |
| 81 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.98988460 |
| 82 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.97265042 |
| 83 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.96646415 |
| 84 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.94469429 |
| 85 | Cocaine addiction_Homo sapiens_hsa05030 | 0.92380939 |
| 86 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.88961786 |
| 87 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.88515782 |
| 88 | GABAergic synapse_Homo sapiens_hsa04727 | 0.87321058 |
| 89 | Phototransduction_Homo sapiens_hsa04744 | 0.87110362 |
| 90 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.86836302 |
| 91 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.86086002 |
| 92 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.85194261 |
| 93 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.84471946 |
| 94 | Mineral absorption_Homo sapiens_hsa04978 | 0.84378395 |
| 95 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.83112874 |
| 96 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.82492267 |
| 97 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.79650542 |
| 98 | RNA transport_Homo sapiens_hsa03013 | 0.79646221 |
| 99 | Peroxisome_Homo sapiens_hsa04146 | 0.77168254 |
| 100 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.76891728 |
| 101 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.75671266 |
| 102 | Carbon metabolism_Homo sapiens_hsa01200 | 0.72839274 |
| 103 | Purine metabolism_Homo sapiens_hsa00230 | 0.72592062 |
| 104 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.68613766 |
| 105 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.68570156 |
| 106 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.67456243 |
| 107 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.67427605 |
| 108 | RNA polymerase_Homo sapiens_hsa03020 | 0.66920064 |
| 109 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.66246114 |
| 110 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.62894846 |
| 111 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.61697057 |
| 112 | Axon guidance_Homo sapiens_hsa04360 | 0.61478761 |
| 113 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.58481474 |
| 114 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.58250463 |
| 115 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.58241302 |
| 116 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.58110153 |
| 117 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.58063636 |
| 118 | Alcoholism_Homo sapiens_hsa05034 | 0.56602047 |
| 119 | RNA degradation_Homo sapiens_hsa03018 | 0.54407787 |
| 120 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.53740055 |
| 121 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.53561077 |
| 122 | Endocytosis_Homo sapiens_hsa04144 | 0.53327120 |
| 123 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.52975870 |
| 124 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.51894398 |
| 125 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.51288432 |
| 126 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51245362 |
| 127 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.50400328 |
| 128 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.49639780 |
| 129 | Gap junction_Homo sapiens_hsa04540 | 0.47652352 |
| 130 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.47083916 |
| 131 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.46934653 |
| 132 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.44162514 |
| 133 | Homologous recombination_Homo sapiens_hsa03440 | 0.42137365 |
| 134 | Bile secretion_Homo sapiens_hsa04976 | 0.40868641 |
| 135 | Melanogenesis_Homo sapiens_hsa04916 | 0.40662048 |
| 136 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.40642843 |
| 137 | Parkinsons disease_Homo sapiens_hsa05012 | 0.40333385 |
| 138 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.40165938 |
| 139 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39402026 |
| 140 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.35692461 |
| 141 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.34063571 |
| 142 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.33242492 |
| 143 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.31848096 |
| 144 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31371793 |
| 145 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.31245307 |
| 146 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.31158989 |
| 147 | Long-term depression_Homo sapiens_hsa04730 | 0.30846024 |
| 148 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.29630025 |
| 149 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.29013273 |
| 150 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.26729578 |

