ANKRD46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.89959467
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.43111863
3synaptic vesicle exocytosis (GO:0016079)5.12494891
4synaptic vesicle maturation (GO:0016188)4.95750814
5glutamate secretion (GO:0014047)4.93656285
6vocalization behavior (GO:0071625)4.88696084
7nucleobase catabolic process (GO:0046113)4.81030301
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70814506
9regulation of synaptic vesicle exocytosis (GO:2000300)4.69439566
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.67614807
11neuron cell-cell adhesion (GO:0007158)4.53309036
12locomotory exploration behavior (GO:0035641)4.44498203
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43664907
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.43477929
15protein localization to synapse (GO:0035418)4.39072264
16regulation of glutamate receptor signaling pathway (GO:1900449)4.32366769
17neurotransmitter-gated ion channel clustering (GO:0072578)4.25846086
18neuronal action potential propagation (GO:0019227)4.25296449
19neurotransmitter secretion (GO:0007269)4.11604023
20regulation of synaptic vesicle transport (GO:1902803)4.11181079
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05192704
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.04859310
23presynaptic membrane organization (GO:0097090)3.95373999
24presynaptic membrane assembly (GO:0097105)3.90478325
25regulation of neuronal synaptic plasticity (GO:0048168)3.86474652
26synaptic transmission, glutamatergic (GO:0035249)3.85170741
27neuron-neuron synaptic transmission (GO:0007270)3.82448761
28regulation of synapse structural plasticity (GO:0051823)3.71742227
29exploration behavior (GO:0035640)3.71537936
30glutamate receptor signaling pathway (GO:0007215)3.71083939
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69847308
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66230372
33gamma-aminobutyric acid transport (GO:0015812)3.65619221
34proline transport (GO:0015824)3.50889778
35establishment of mitochondrion localization (GO:0051654)3.46978135
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43676829
37neurotransmitter transport (GO:0006836)3.42023491
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.41505000
39neuron recognition (GO:0008038)3.39780975
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39122747
41positive regulation of synapse maturation (GO:0090129)3.39018042
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.38680526
43layer formation in cerebral cortex (GO:0021819)3.37370387
44long-term synaptic potentiation (GO:0060291)3.37291194
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32786836
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.29556216
47regulation of postsynaptic membrane potential (GO:0060078)3.27257630
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26030366
49positive regulation of membrane potential (GO:0045838)3.25639984
50regulation of synaptic plasticity (GO:0048167)3.24438971
51transmission of nerve impulse (GO:0019226)3.20335969
52postsynaptic membrane organization (GO:0001941)3.19737122
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18186990
54regulation of neurotransmitter levels (GO:0001505)3.17274036
55cerebellar granule cell differentiation (GO:0021707)3.14441582
56long-term memory (GO:0007616)3.14273670
57cellular potassium ion homeostasis (GO:0030007)3.13847609
58cell migration in hindbrain (GO:0021535)3.13766027
59glycosphingolipid biosynthetic process (GO:0006688)3.13658159
60neuromuscular process controlling posture (GO:0050884)3.10686981
61regulation of neurotransmitter secretion (GO:0046928)3.10354767
62activation of protein kinase A activity (GO:0034199)3.10168645
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07437245
64synaptic vesicle endocytosis (GO:0048488)3.06387316
65protein localization to cilium (GO:0061512)3.04546893
66negative regulation of dendrite morphogenesis (GO:0050774)3.04040171
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00747686
68axonal fasciculation (GO:0007413)2.97498870
69positive regulation of mitochondrial fission (GO:0090141)2.97166275
70dendritic spine morphogenesis (GO:0060997)2.96535691
71neurofilament cytoskeleton organization (GO:0060052)2.94949131
72behavioral response to cocaine (GO:0048148)2.94293327
73positive regulation of dendritic spine morphogenesis (GO:0061003)2.94157893
74behavioral fear response (GO:0001662)2.93284480
75behavioral defense response (GO:0002209)2.93284480
76regulation of neurotransmitter transport (GO:0051588)2.92852112
77dendrite morphogenesis (GO:0048813)2.92056111
78membrane hyperpolarization (GO:0060081)2.92004264
79response to histamine (GO:0034776)2.88596736
80regulation of dendritic spine morphogenesis (GO:0061001)2.88242914
81regulation of vesicle fusion (GO:0031338)2.88061173
82membrane depolarization (GO:0051899)2.87532673
83cerebellar Purkinje cell differentiation (GO:0021702)2.87135833
84positive regulation of synaptic transmission (GO:0050806)2.86486337
85neuromuscular synaptic transmission (GO:0007274)2.86223856
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85215182
87regulation of glutamate secretion (GO:0014048)2.84629407
88auditory behavior (GO:0031223)2.83855440
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83135549
90positive regulation of neurotransmitter transport (GO:0051590)2.83099072
91neuromuscular process controlling balance (GO:0050885)2.82644479
92synaptic transmission (GO:0007268)2.82171833
93regulation of synaptic transmission (GO:0050804)2.81685855
94membrane depolarization during action potential (GO:0086010)2.81448089
95regulation of voltage-gated calcium channel activity (GO:1901385)2.80420207
96negative regulation of dendrite development (GO:2000171)2.79706088
97regulation of female receptivity (GO:0045924)2.78059903
98learning (GO:0007612)2.77729325
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.77676948
100ATP hydrolysis coupled proton transport (GO:0015991)2.77676948
101synapse assembly (GO:0007416)2.76290565
102innervation (GO:0060384)2.75841963
103negative regulation of microtubule polymerization (GO:0031115)2.74989057
104behavioral response to nicotine (GO:0035095)2.74708177
105fear response (GO:0042596)2.74200623
106mechanosensory behavior (GO:0007638)2.73980763
107neuronal ion channel clustering (GO:0045161)2.72157761
108positive regulation of synapse assembly (GO:0051965)2.72023779
109response to auditory stimulus (GO:0010996)2.70790133
110mating behavior (GO:0007617)2.70498363
111adult walking behavior (GO:0007628)2.70028952
112DNA double-strand break processing (GO:0000729)2.69661684
113vesicle transport along microtubule (GO:0047496)2.69291977
114adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.66638725
115central nervous system projection neuron axonogenesis (GO:0021952)2.65688490
116cochlea development (GO:0090102)2.63472618
117regulation of dendritic spine development (GO:0060998)2.59808779
118startle response (GO:0001964)2.55735057
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55686532
120cerebral cortex radially oriented cell migration (GO:0021799)2.51893436
121hippocampus development (GO:0021766)2.51747484
122nonmotile primary cilium assembly (GO:0035058)2.51190230
123positive regulation of amino acid transport (GO:0051957)2.49836889
124regulation of cAMP-dependent protein kinase activity (GO:2000479)2.48653890
125reflex (GO:0060004)2.48555532
126limb bud formation (GO:0060174)2.46357842
127synapse organization (GO:0050808)2.45318572
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.45137175
129mitochondrion transport along microtubule (GO:0047497)2.45137175
130establishment of synaptic vesicle localization (GO:0097480)2.45010497
131synaptic vesicle transport (GO:0048489)2.45010497
132intraciliary transport (GO:0042073)2.43258205
133regulation of feeding behavior (GO:0060259)2.41608024
134establishment of vesicle localization (GO:0051650)2.40906391
135retinal ganglion cell axon guidance (GO:0031290)2.40357464
136C4-dicarboxylate transport (GO:0015740)2.39697485
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38576368
138neuronal action potential (GO:0019228)2.34474440
139regulation of respiratory system process (GO:0044065)2.34122094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05850370
2GBX2_23144817_ChIP-Seq_PC3_Human3.93562225
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19058681
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13184740
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90885239
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66743059
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66743059
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62872255
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62679293
10REST_21632747_ChIP-Seq_MESCs_Mouse2.58669123
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56798260
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52807214
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51552180
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49976066
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44937927
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.42643118
17TAF15_26573619_Chip-Seq_HEK293_Human2.35158071
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.34994000
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.33657100
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30774168
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29469772
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26755766
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.24523807
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18952188
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.18732644
26DROSHA_22980978_ChIP-Seq_HELA_Human2.17008332
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.16270179
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11207274
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.03168863
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96400648
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90488821
32AR_21572438_ChIP-Seq_LNCaP_Human1.86628686
33EWS_26573619_Chip-Seq_HEK293_Human1.82553546
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77364580
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70148811
36SMAD4_21799915_ChIP-Seq_A2780_Human1.69984272
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68070841
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64793910
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63646523
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63280270
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62855294
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.57747164
43* P300_19829295_ChIP-Seq_ESCs_Human1.52412282
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52379772
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51658837
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.51127784
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50421838
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49082660
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46885729
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44619637
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43092895
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39899320
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38220204
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38092477
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37103741
56FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33852996
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.32848730
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31998663
59AR_25329375_ChIP-Seq_VCAP_Human1.31792904
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.31207096
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29801320
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.28761966
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27976402
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27358352
65IGF1R_20145208_ChIP-Seq_DFB_Human1.26490479
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25845765
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24291520
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.23222956
69VDR_22108803_ChIP-Seq_LS180_Human1.22944211
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22934834
71ZNF274_21170338_ChIP-Seq_K562_Hela1.21749366
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20983722
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20433206
74CBP_20019798_ChIP-Seq_JUKART_Human1.20433206
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20288548
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19560669
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.19182740
78STAT3_23295773_ChIP-Seq_U87_Human1.17238992
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15714571
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15687763
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15687763
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.15213382
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14772211
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13112316
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09909999
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.09444040
87* TAL1_26923725_Chip-Seq_HPCs_Mouse1.09442505
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08279841
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07890556
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07508612
91AR_19668381_ChIP-Seq_PC3_Human1.07482618
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06956178
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06739689
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06549635
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05915869
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05131410
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.04588425
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04449924
99* RNF2_27304074_Chip-Seq_NSC_Mouse1.04325722
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04167973
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03947059
102* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03190270
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.03081009
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.02866045
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02463010
106ER_23166858_ChIP-Seq_MCF-7_Human1.02165402
107* TCF4_23295773_ChIP-Seq_U87_Human1.01859064
108* FLI1_21867929_ChIP-Seq_TH2_Mouse1.01642634
109P53_22387025_ChIP-Seq_ESCs_Mouse1.01328037
110P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99162565
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98683243
112TP53_22573176_ChIP-Seq_HFKS_Human0.98121096
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97770419
114SOX9_26525672_Chip-Seq_HEART_Mouse0.97586762
115AHR_22903824_ChIP-Seq_MCF-7_Human0.97582555
116FUS_26573619_Chip-Seq_HEK293_Human0.97538657
117JUN_21703547_ChIP-Seq_K562_Human0.95494328
118* RUNX2_22187159_ChIP-Seq_PCA_Human0.95109725
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93611488
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93595564
121* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92646249
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91727867
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.91464855
124* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90312911
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90218226
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.90178017
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89001382
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.88929099
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.88655835
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.87921556
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83342718
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82882069
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81181374
134BCAT_22108803_ChIP-Seq_LS180_Human0.81084865
135KDM2B_26808549_Chip-Seq_REH_Human0.80474812
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.80353568
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80217860
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79962891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.58138534
2MP0003880_abnormal_central_pattern4.95455488
3MP0003635_abnormal_synaptic_transmissio3.81605448
4MP0004270_analgesia3.68102800
5MP0001968_abnormal_touch/_nociception3.45667043
6MP0009745_abnormal_behavioral_response3.26934058
7MP0002063_abnormal_learning/memory/cond3.13201632
8MP0002064_seizures3.11989221
9MP0002736_abnormal_nociception_after3.00667600
10MP0009046_muscle_twitch2.92687194
11MP0002735_abnormal_chemical_nociception2.87190717
12MP0002272_abnormal_nervous_system2.72921188
13MP0002734_abnormal_mechanical_nocicepti2.70453415
14MP0002822_catalepsy2.67699894
15MP0002572_abnormal_emotion/affect_behav2.66018112
16MP0005423_abnormal_somatic_nervous2.40014330
17MP0001486_abnormal_startle_reflex2.38020596
18MP0002102_abnormal_ear_morphology2.24933470
19MP0002733_abnormal_thermal_nociception2.21492055
20MP0003329_amyloid_beta_deposits2.18807184
21MP0006276_abnormal_autonomic_nervous2.13296008
22MP0001970_abnormal_pain_threshold2.10517060
23MP0001440_abnormal_grooming_behavior2.08564017
24MP0002067_abnormal_sensory_capabilities2.03033914
25MP0001501_abnormal_sleep_pattern2.01838602
26MP0009780_abnormal_chondrocyte_physiolo2.00773992
27MP0004858_abnormal_nervous_system1.80451667
28MP0001529_abnormal_vocalization1.78340884
29MP0008877_abnormal_DNA_methylation1.76789942
30MP0000778_abnormal_nervous_system1.74816650
31MP0002184_abnormal_innervation1.72894951
32MP0003121_genomic_imprinting1.72339202
33MP0008569_lethality_at_weaning1.71379540
34MP0005646_abnormal_pituitary_gland1.67937694
35MP0004924_abnormal_behavior1.65556492
36MP0005386_behavior/neurological_phenoty1.65556492
37MP0004811_abnormal_neuron_physiology1.62859865
38MP0001905_abnormal_dopamine_level1.59354408
39MP0002557_abnormal_social/conspecific_i1.56715516
40MP0001984_abnormal_olfaction1.54293453
41MP0004142_abnormal_muscle_tone1.50915979
42MP0000955_abnormal_spinal_cord1.50154618
43MP0008789_abnormal_olfactory_epithelium1.48899119
44MP0002909_abnormal_adrenal_gland1.48185387
45MP0002882_abnormal_neuron_morphology1.41162506
46MP0002066_abnormal_motor_capabilities/c1.40404756
47MP0003122_maternal_imprinting1.38922542
48MP0003633_abnormal_nervous_system1.34548083
49MP0004885_abnormal_endolymph1.33679078
50MP0003879_abnormal_hair_cell1.32701032
51MP0002837_dystrophic_cardiac_calcinosis1.27634745
52MP0005187_abnormal_penis_morphology1.25252537
53MP0003890_abnormal_embryonic-extraembry1.23457314
54MP0000751_myopathy1.20442584
55MP0003787_abnormal_imprinting1.18789223
56MP0000920_abnormal_myelination1.18726877
57MP0003631_nervous_system_phenotype1.18330636
58MP0005551_abnormal_eye_electrophysiolog1.16147401
59MP0005253_abnormal_eye_physiology1.15906078
60MP0002234_abnormal_pharynx_morphology1.15171008
61MP0002229_neurodegeneration1.13106502
62MP0000604_amyloidosis1.11085495
63MP0006072_abnormal_retinal_apoptosis1.10417704
64MP0004133_heterotaxia1.08890677
65MP0001502_abnormal_circadian_rhythm1.07704513
66MP0003119_abnormal_digestive_system1.07484347
67MP0004147_increased_porphyrin_level1.07086188
68MP0000566_synostosis1.06611595
69MP0003690_abnormal_glial_cell1.01756184
70MP0002876_abnormal_thyroid_physiology1.01448063
71MP0005645_abnormal_hypothalamus_physiol1.01128178
72MP0003634_abnormal_glial_cell0.99929924
73MP0002152_abnormal_brain_morphology0.96361164
74MP0008872_abnormal_physiological_respon0.95780832
75MP0000013_abnormal_adipose_tissue0.94832621
76MP0008058_abnormal_DNA_repair0.94654097
77MP0004742_abnormal_vestibular_system0.94223077
78MP0002069_abnormal_eating/drinking_beha0.93302686
79MP0008995_early_reproductive_senescence0.93179284
80MP0008874_decreased_physiological_sensi0.91870163
81MP0000049_abnormal_middle_ear0.91278442
82MP0002233_abnormal_nose_morphology0.91276347
83MP0010386_abnormal_urinary_bladder0.89757685
84MP0003632_abnormal_nervous_system0.89535284
85MP0003861_abnormal_nervous_system0.89184661
86MP0001986_abnormal_taste_sensitivity0.88407298
87MP0003938_abnormal_ear_development0.88054082
88MP0001963_abnormal_hearing_physiology0.87837164
89MP0001188_hyperpigmentation0.87432174
90MP0001177_atelectasis0.83225055
91MP0005535_abnormal_body_temperature0.82630210
92MP0004145_abnormal_muscle_electrophysio0.82484972
93MP0004085_abnormal_heartbeat0.81990288
94MP0002752_abnormal_somatic_nervous0.81565792
95MP0001299_abnormal_eye_distance/0.79345350
96MP0004043_abnormal_pH_regulation0.78441620
97MP0001664_abnormal_digestion0.77204724
98MP0006292_abnormal_olfactory_placode0.77069883
99MP0003567_abnormal_fetal_cardiomyocyte0.75712289
100MP0003221_abnormal_cardiomyocyte_apopto0.75257032
101MP0000647_abnormal_sebaceous_gland0.74907380
102MP0003937_abnormal_limbs/digits/tail_de0.74360840
103MP0002090_abnormal_vision0.72949006
104MP0005394_taste/olfaction_phenotype0.71246478
105MP0005499_abnormal_olfactory_system0.71246478
106MP0005171_absent_coat_pigmentation0.71011835
107MP0005084_abnormal_gallbladder_morpholo0.69667417
108MP0004215_abnormal_myocardial_fiber0.68477078
109MP0003698_abnormal_male_reproductive0.67786011
110MP0004130_abnormal_muscle_cell0.67197970
111MP0006035_abnormal_mitochondrial_morpho0.66170522
112MP0002653_abnormal_ependyma_morphology0.65217607
113MP0003075_altered_response_to0.63028415
114MP0004484_altered_response_of0.62051606
115MP0001485_abnormal_pinna_reflex0.61279255
116MP0000631_abnormal_neuroendocrine_gland0.58144059
117MP0004036_abnormal_muscle_relaxation0.57655646
118MP0000747_muscle_weakness0.56483660
119MP0001943_abnormal_respiration0.56334415
120MP0003137_abnormal_impulse_conducting0.50289322
121MP0005623_abnormal_meninges_morphology0.49803046
122MP0008875_abnormal_xenobiotic_pharmacok0.49124298
123MP0003183_abnormal_peptide_metabolism0.47895205
124MP0002638_abnormal_pupillary_reflex0.47816660
125MP0002751_abnormal_autonomic_nervous0.47344801
126MP0000026_abnormal_inner_ear0.47316760
127MP0010770_preweaning_lethality0.46949967
128MP0002082_postnatal_lethality0.46949967
129MP0004233_abnormal_muscle_weight0.46685184

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.05559909
2Myokymia (HP:0002411)6.23639835
3Focal seizures (HP:0007359)5.04570110
4Atonic seizures (HP:0010819)4.72459962
5Epileptic encephalopathy (HP:0200134)4.59245897
6Visual hallucinations (HP:0002367)4.32548188
7Febrile seizures (HP:0002373)3.87923273
8Hyperventilation (HP:0002883)3.80271983
9Absence seizures (HP:0002121)3.74890536
10Progressive cerebellar ataxia (HP:0002073)3.70261459
11Action tremor (HP:0002345)3.67354103
12Pheochromocytoma (HP:0002666)3.65595035
13Dialeptic seizures (HP:0011146)3.60406007
14Ankle clonus (HP:0011448)3.46335357
15Generalized tonic-clonic seizures (HP:0002069)3.44282543
16Supranuclear gaze palsy (HP:0000605)3.42892081
17Termporal pattern (HP:0011008)3.40478502
18Insidious onset (HP:0003587)3.40478502
19Impaired vibration sensation in the lower limbs (HP:0002166)3.28593198
20Neuroendocrine neoplasm (HP:0100634)3.21955672
21Medial flaring of the eyebrow (HP:0010747)3.18052438
22Abnormal eating behavior (HP:0100738)3.15329527
23Abnormality of the corticospinal tract (HP:0002492)3.08590133
24Neurofibrillary tangles (HP:0002185)2.98390540
25Spastic gait (HP:0002064)2.95809267
26Broad-based gait (HP:0002136)2.94275767
27Scanning speech (HP:0002168)2.86660908
28Anxiety (HP:0000739)2.85293926
29Urinary urgency (HP:0000012)2.83889857
30Depression (HP:0000716)2.82012779
31Cerebral inclusion bodies (HP:0100314)2.81362313
32Urinary bladder sphincter dysfunction (HP:0002839)2.81194159
33Dysmetria (HP:0001310)2.80996933
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.77821442
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.77821442
36Poor eye contact (HP:0000817)2.76113460
37Dysdiadochokinesis (HP:0002075)2.75741415
38Cortical dysplasia (HP:0002539)2.74697941
39Abnormality of the labia minora (HP:0012880)2.73202802
40Limb dystonia (HP:0002451)2.70868421
41Truncal ataxia (HP:0002078)2.69838444
42Torticollis (HP:0000473)2.69404015
43Gaze-evoked nystagmus (HP:0000640)2.69335070
44Genital tract atresia (HP:0001827)2.66707155
45Polyphagia (HP:0002591)2.64008183
46Vaginal atresia (HP:0000148)2.62853115
47Amblyopia (HP:0000646)2.59792888
48Abnormal social behavior (HP:0012433)2.59738722
49Impaired social interactions (HP:0000735)2.59738722
50Focal dystonia (HP:0004373)2.55486040
51Epileptiform EEG discharges (HP:0011182)2.54665648
52Postural instability (HP:0002172)2.43916801
53True hermaphroditism (HP:0010459)2.40813457
54Craniofacial dystonia (HP:0012179)2.40741314
55EEG with generalized epileptiform discharges (HP:0011198)2.40403565
56Amyotrophic lateral sclerosis (HP:0007354)2.37809814
57Lower limb muscle weakness (HP:0007340)2.37476694
58Intestinal atresia (HP:0011100)2.34703583
59Progressive inability to walk (HP:0002505)2.34353971
60Abnormality of the lower motor neuron (HP:0002366)2.33802861
61Gait imbalance (HP:0002141)2.33731254
62Hypsarrhythmia (HP:0002521)2.30461000
63Pancreatic cysts (HP:0001737)2.29551503
64Oligodactyly (hands) (HP:0001180)2.28512590
65Lissencephaly (HP:0001339)2.28093820
66Morphological abnormality of the pyramidal tract (HP:0002062)2.27646657
67Exercise-induced muscle cramps (HP:0003710)2.26627806
68Drooling (HP:0002307)2.26388821
69Excessive salivation (HP:0003781)2.26388821
70Impaired vibratory sensation (HP:0002495)2.25554045
71Pancreatic fibrosis (HP:0100732)2.25390951
72Diplopia (HP:0000651)2.25064371
73Abnormality of binocular vision (HP:0011514)2.25064371
74Mutism (HP:0002300)2.23879740
75Intention tremor (HP:0002080)2.23659242
76Bradykinesia (HP:0002067)2.22635068
77Abnormality of midbrain morphology (HP:0002418)2.20822363
78Molar tooth sign on MRI (HP:0002419)2.20822363
79Inability to walk (HP:0002540)2.20586359
80Abnormality of glycolysis (HP:0004366)2.17967399
81Increased serum pyruvate (HP:0003542)2.17967399
82Split foot (HP:0001839)2.15068772
83Nephronophthisis (HP:0000090)2.12883211
84Impaired pain sensation (HP:0007328)2.12787653
85Abnormality of pain sensation (HP:0010832)2.12787653
86Volvulus (HP:0002580)2.12336926
87Rimmed vacuoles (HP:0003805)2.11803174
88Poor coordination (HP:0002370)2.09276037
89Neoplasm of the peripheral nervous system (HP:0100007)2.08636605
90Fetal akinesia sequence (HP:0001989)2.07778699
91Failure to thrive in infancy (HP:0001531)2.07312049
92Spastic tetraplegia (HP:0002510)2.07118792
93Absent speech (HP:0001344)2.06498895
94Dysmetric saccades (HP:0000641)2.06483687
95Delusions (HP:0000746)2.06099895
96Poor suck (HP:0002033)2.05745356
97Cerebral hypomyelination (HP:0006808)2.05569360
98Status epilepticus (HP:0002133)2.04713284
99Specific learning disability (HP:0001328)2.03691051
100Akinesia (HP:0002304)2.02018956
101Megalencephaly (HP:0001355)2.01525581
102Generalized myoclonic seizures (HP:0002123)2.00268821
103Congenital primary aphakia (HP:0007707)1.97805849
104Thyroid-stimulating hormone excess (HP:0002925)1.96887105
105Muscular hypotonia of the trunk (HP:0008936)1.96365059
106Postural tremor (HP:0002174)1.95590868
107Clonus (HP:0002169)1.94748161
108Retinal dysplasia (HP:0007973)1.92419369
109Gait ataxia (HP:0002066)1.92250224
110Neuronal loss in central nervous system (HP:0002529)1.91384779
111Hemiparesis (HP:0001269)1.91036443
112Abnormal mitochondria in muscle tissue (HP:0008316)1.90494075
113Pachygyria (HP:0001302)1.90165299
114Psychosis (HP:0000709)1.89996132
115Resting tremor (HP:0002322)1.89631847
116Acute necrotizing encephalopathy (HP:0006965)1.88807227
117Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88646279
118Hypoplasia of the brainstem (HP:0002365)1.88646279
119Dyskinesia (HP:0100660)1.88511948
120Paraplegia (HP:0010550)1.88178698
121Blue irides (HP:0000635)1.87254027
122Impaired smooth pursuit (HP:0007772)1.86982678
123Agitation (HP:0000713)1.86706700
124Cerebral hemorrhage (HP:0001342)1.86606724
125CNS hypomyelination (HP:0003429)1.84706849
126Nephrogenic diabetes insipidus (HP:0009806)1.84703246
127Esotropia (HP:0000565)1.84502042
128Genetic anticipation (HP:0003743)1.84057818
129Papillary thyroid carcinoma (HP:0002895)1.83654103
130Hypoventilation (HP:0002791)1.83223070
131Rigidity (HP:0002063)1.83038849
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.80508607
133Optic nerve hypoplasia (HP:0000609)1.79086154
134Postaxial hand polydactyly (HP:0001162)1.76819749
135Decreased testicular size (HP:0008734)1.75703167
136Broad foot (HP:0001769)1.75163468
137Hyperglycinemia (HP:0002154)1.74793433
138Exotropia (HP:0000577)1.74036547
139Hypothermia (HP:0002045)1.73574358
140Sleep apnea (HP:0010535)1.73523638
141Medulloblastoma (HP:0002885)1.68447495
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68079831
143Abnormality of alanine metabolism (HP:0010916)1.68079831
144Hyperalaninemia (HP:0003348)1.68079831
145Methylmalonic acidemia (HP:0002912)1.67909163
146Labial hypoplasia (HP:0000066)1.66961798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.93090737
2EPHA43.65273919
3CASK3.58753961
4MAP3K93.20995639
5MAP3K43.08242754
6MARK12.78297225
7TRIM282.70764135
8MINK12.68415052
9WNK32.66141372
10MAP2K72.62440416
11MAP3K122.56505997
12MAP4K22.46448338
13ERBB32.34447724
14DAPK22.33919307
15KSR22.04980460
16MAP2K42.04183015
17PAK61.97479405
18NTRK11.95466847
19CDK191.86046269
20DYRK21.71677321
21ARAF1.71425355
22NTRK21.69229266
23PLK21.67663468
24SRPK11.62041056
25OXSR11.59112621
26DAPK11.44498141
27CDK51.44286515
28PRPF4B1.43250804
29RIPK41.41841553
30KSR11.40504124
31GRK51.38321345
32MAPK131.34599091
33SGK4941.34234518
34SGK2231.34234518
35OBSCN1.32882123
36PRKCG1.28887597
37CAMKK11.28521690
38CSNK1G11.27127671
39FRK1.26813819
40UHMK11.22725043
41TNIK1.20518039
42BMPR1B1.19567533
43PHKG21.19528285
44PHKG11.19528285
45PRKD31.17476093
46PNCK1.10948902
47CAMKK21.09477845
48CAMK2A1.07863779
49LMTK21.05463234
50MAP3K21.03389384
51ADRBK21.03342755
52FES1.01838679
53CAMK2B1.01602178
54STK391.00989946
55CCNB11.00162034
56MKNK20.99936442
57INSRR0.97990271
58CDK140.96411724
59CDK180.95623140
60DYRK30.94362260
61CSNK1G20.91950803
62CDK150.91579008
63PTK2B0.89435871
64STK38L0.85868743
65PAK30.85496994
66RET0.85323212
67MKNK10.84092757
68LIMK10.82343630
69MAP3K60.81104928
70BCR0.80759815
71SGK20.79284529
72CDK11A0.77751859
73MAP3K130.74482197
74TYRO30.73881780
75PRKCE0.73244823
76PRKCH0.72319470
77CAMK2G0.72229060
78STK380.69784590
79LATS20.69404538
80FER0.68979854
81PINK10.68606476
82RAF10.68496383
83CAMK10.66556479
84CAMK2D0.64945887
85AKT30.64497998
86PDK30.63718517
87PDK40.63718517
88RPS6KA40.62243649
89GRK10.62184115
90PLK30.61450528
91CSNK1G30.61117495
92MAP2K10.60838351
93MAPKAPK50.60563381
94ROCK20.60488845
95DYRK1A0.58942240
96NME10.58737002
97SIK20.56697845
98SGK30.55954580
99PDPK10.55809010
100NUAK10.55264768
101EPHA30.54727080
102STK110.52683902
103BCKDK0.51984468
104SGK10.50539682
105PDK10.50532072
106WNK40.50384258
107PRKCZ0.50300757
108CSNK1D0.49964116
109SIK30.48960762
110WNK10.48591889
111CAMK40.48060173
112DYRK1B0.47924706
113VRK10.47846944
114ADRBK10.47678609
115BMPR20.47283911
116MAP3K10.46883564
117MARK20.46277718
118PKN10.45005920
119DAPK30.44425110
120CSNK1E0.44076326
121BRAF0.43553602
122NEK10.43448486
123EIF2AK30.43367592
124FGFR20.43071238
125FYN0.41935003
126ACVR1B0.41694048
127PRKACA0.41537313
128CSNK1A1L0.40180704
129STK160.39987583
130PRKAA10.39727143
131TSSK60.39426338
132FGR0.38978601
133MYLK0.38682275
134ZAK0.38681700
135CSNK1A10.38049433
136MAP3K50.36119371
137PRKACB0.34019909
138PRKG10.32085025
139PLK40.30020687

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.64196808
2Nicotine addiction_Homo sapiens_hsa050333.59700253
3GABAergic synapse_Homo sapiens_hsa047272.58185903
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56809960
5Circadian entrainment_Homo sapiens_hsa047132.42635915
6Olfactory transduction_Homo sapiens_hsa047402.41310743
7Collecting duct acid secretion_Homo sapiens_hsa049662.31001144
8Glutamatergic synapse_Homo sapiens_hsa047242.28643193
9Long-term potentiation_Homo sapiens_hsa047202.26383509
10Morphine addiction_Homo sapiens_hsa050322.26289209
11Amphetamine addiction_Homo sapiens_hsa050312.17119759
12Protein export_Homo sapiens_hsa030602.15685825
13Dopaminergic synapse_Homo sapiens_hsa047282.05836830
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96370067
15Salivary secretion_Homo sapiens_hsa049701.83340994
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71078342
17Insulin secretion_Homo sapiens_hsa049111.69532823
18Cholinergic synapse_Homo sapiens_hsa047251.64976056
19Taste transduction_Homo sapiens_hsa047421.64464826
20Gastric acid secretion_Homo sapiens_hsa049711.59096986
21Long-term depression_Homo sapiens_hsa047301.55799872
22Serotonergic synapse_Homo sapiens_hsa047261.54719386
23Renin secretion_Homo sapiens_hsa049241.51428173
24Vibrio cholerae infection_Homo sapiens_hsa051101.50355206
25Cocaine addiction_Homo sapiens_hsa050301.45051369
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43878610
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42007328
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39759237
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39706210
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38206974
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34701293
32Oxytocin signaling pathway_Homo sapiens_hsa049211.32391355
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31856464
34Calcium signaling pathway_Homo sapiens_hsa040201.31722816
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28577258
36Oxidative phosphorylation_Homo sapiens_hsa001901.22296090
37Circadian rhythm_Homo sapiens_hsa047101.19824539
38Gap junction_Homo sapiens_hsa045401.18418204
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17351838
40Basal transcription factors_Homo sapiens_hsa030221.16125240
41Phototransduction_Homo sapiens_hsa047441.14586932
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14524278
43Nitrogen metabolism_Homo sapiens_hsa009101.13970267
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11575146
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10170824
46GnRH signaling pathway_Homo sapiens_hsa049121.07264728
47Axon guidance_Homo sapiens_hsa043601.03499927
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03092906
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01964982
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01669831
51Cardiac muscle contraction_Homo sapiens_hsa042601.00893291
52Butanoate metabolism_Homo sapiens_hsa006500.99518595
53Regulation of autophagy_Homo sapiens_hsa041400.97930199
54cAMP signaling pathway_Homo sapiens_hsa040240.96600042
55beta-Alanine metabolism_Homo sapiens_hsa004100.94189704
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93811022
57Vitamin B6 metabolism_Homo sapiens_hsa007500.93754901
58Alzheimers disease_Homo sapiens_hsa050100.92990029
59Peroxisome_Homo sapiens_hsa041460.89869557
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89828223
61Parkinsons disease_Homo sapiens_hsa050120.88864295
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86346906
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86322076
64RNA degradation_Homo sapiens_hsa030180.85607299
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83087422
66Estrogen signaling pathway_Homo sapiens_hsa049150.82754067
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81032902
68Glioma_Homo sapiens_hsa052140.80110835
69Arginine and proline metabolism_Homo sapiens_hsa003300.79382712
70Pyruvate metabolism_Homo sapiens_hsa006200.78929328
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.78655878
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78185474
73Melanogenesis_Homo sapiens_hsa049160.77442093
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75804648
75Type II diabetes mellitus_Homo sapiens_hsa049300.75357679
76ErbB signaling pathway_Homo sapiens_hsa040120.75264438
77Fatty acid elongation_Homo sapiens_hsa000620.71299405
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67248779
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67204572
80Bile secretion_Homo sapiens_hsa049760.64350917
81Thyroid hormone synthesis_Homo sapiens_hsa049180.63699145
82Ether lipid metabolism_Homo sapiens_hsa005650.63175127
83Arginine biosynthesis_Homo sapiens_hsa002200.61096208
84RNA polymerase_Homo sapiens_hsa030200.60551779
85Fanconi anemia pathway_Homo sapiens_hsa034600.59766560
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.58984461
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57628952
88Hedgehog signaling pathway_Homo sapiens_hsa043400.57235668
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56064893
90Pancreatic secretion_Homo sapiens_hsa049720.55779136
91Oocyte meiosis_Homo sapiens_hsa041140.54099479
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53017070
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.52664239
94Sulfur metabolism_Homo sapiens_hsa009200.52187126
95mRNA surveillance pathway_Homo sapiens_hsa030150.51984075
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51807709
97Non-homologous end-joining_Homo sapiens_hsa034500.48683650
98Selenocompound metabolism_Homo sapiens_hsa004500.48676139
99Caffeine metabolism_Homo sapiens_hsa002320.47822995
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47264236
101Glucagon signaling pathway_Homo sapiens_hsa049220.47204622
102Tryptophan metabolism_Homo sapiens_hsa003800.46511334
103Dorso-ventral axis formation_Homo sapiens_hsa043200.44515899
104Ras signaling pathway_Homo sapiens_hsa040140.43905293
105Hippo signaling pathway_Homo sapiens_hsa043900.43667138
106MAPK signaling pathway_Homo sapiens_hsa040100.43547297
107Dilated cardiomyopathy_Homo sapiens_hsa054140.43259857
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42652674
109RNA transport_Homo sapiens_hsa030130.42544321
110Metabolic pathways_Homo sapiens_hsa011000.42374891
111Carbon metabolism_Homo sapiens_hsa012000.42326889
112Prion diseases_Homo sapiens_hsa050200.42250407
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41907310
114Rheumatoid arthritis_Homo sapiens_hsa053230.41797528
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40950949
116Choline metabolism in cancer_Homo sapiens_hsa052310.40674261
117Huntingtons disease_Homo sapiens_hsa050160.40570150
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38529518
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.37823126
120Biosynthesis of amino acids_Homo sapiens_hsa012300.37676157
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.37255852
122Endocytosis_Homo sapiens_hsa041440.36245659
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.35365253
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35092630
125Phagosome_Homo sapiens_hsa041450.34668702
126Rap1 signaling pathway_Homo sapiens_hsa040150.34519016
127Propanoate metabolism_Homo sapiens_hsa006400.32739563
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31771819
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.31282887
130VEGF signaling pathway_Homo sapiens_hsa043700.29896772
131Fatty acid metabolism_Homo sapiens_hsa012120.28690861
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28566175
133Alcoholism_Homo sapiens_hsa050340.27481891
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27058422
135Insulin signaling pathway_Homo sapiens_hsa049100.26756383
136Steroid biosynthesis_Homo sapiens_hsa001000.26572382

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