ANKRD49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)4.81890085
2CENP-A containing nucleosome assembly (GO:0034080)4.81096773
3chromatin remodeling at centromere (GO:0031055)4.60221701
4DNA deamination (GO:0045006)4.56333608
5ribosomal small subunit assembly (GO:0000028)4.45707055
6DNA strand elongation involved in DNA replication (GO:0006271)4.42169827
7positive regulation of gamma-delta T cell activation (GO:0046645)4.39590144
8telomere maintenance via semi-conservative replication (GO:0032201)4.33800205
9kinetochore assembly (GO:0051382)4.31925387
10viral mRNA export from host cell nucleus (GO:0046784)4.29085196
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28240110
12negative regulation of cell killing (GO:0031342)4.28240110
13DNA replication initiation (GO:0006270)4.23007957
14DNA strand elongation (GO:0022616)4.21496992
15DNA replication-independent nucleosome organization (GO:0034724)4.12965124
16DNA replication-independent nucleosome assembly (GO:0006336)4.12965124
17mitotic metaphase plate congression (GO:0007080)4.09558149
18mitotic recombination (GO:0006312)4.03264972
19DNA unwinding involved in DNA replication (GO:0006268)4.01302682
20protein localization to kinetochore (GO:0034501)3.97806750
21telomere maintenance via recombination (GO:0000722)3.97629822
22IMP biosynthetic process (GO:0006188)3.96607623
23histone exchange (GO:0043486)3.93219575
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88770365
25meiotic chromosome segregation (GO:0045132)3.77414119
26maturation of SSU-rRNA (GO:0030490)3.75147887
27metaphase plate congression (GO:0051310)3.74849008
28IMP metabolic process (GO:0046040)3.66960989
29attachment of spindle microtubules to kinetochore (GO:0008608)3.66659157
30regulation of gamma-delta T cell differentiation (GO:0045586)3.66181081
31cell wall macromolecule metabolic process (GO:0044036)3.65205026
32protein localization to chromosome, centromeric region (GO:0071459)3.64415804
33rRNA modification (GO:0000154)3.60701562
34negative T cell selection (GO:0043383)3.60373620
35regulation of gamma-delta T cell activation (GO:0046643)3.59272104
36interferon-gamma production (GO:0032609)3.56104901
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.55529069
38regulation of B cell receptor signaling pathway (GO:0050855)3.53877907
39translesion synthesis (GO:0019985)3.51378493
40telomere maintenance via telomere lengthening (GO:0010833)3.51091780
41replication fork processing (GO:0031297)3.50541107
42DNA replication checkpoint (GO:0000076)3.49600738
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.49050003
44nucleobase biosynthetic process (GO:0046112)3.48613142
45establishment of chromosome localization (GO:0051303)3.48439877
46maturation of 5.8S rRNA (GO:0000460)3.47848895
47mitotic sister chromatid cohesion (GO:0007064)3.47394456
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.40629247
49positive regulation of granulocyte differentiation (GO:0030854)3.34113133
50rRNA methylation (GO:0031167)3.33647912
51ribosome biogenesis (GO:0042254)3.31482035
52mitotic nuclear envelope disassembly (GO:0007077)3.27909227
53folic acid-containing compound biosynthetic process (GO:0009396)3.26417355
54positive regulation of B cell differentiation (GO:0045579)3.24425055
55cell wall macromolecule catabolic process (GO:0016998)3.23519764
56mitotic chromosome condensation (GO:0007076)3.23485910
57purine nucleobase biosynthetic process (GO:0009113)3.23052127
58negative thymic T cell selection (GO:0045060)3.21230810
59ribonucleoprotein complex biogenesis (GO:0022613)3.21191506
60ribosomal small subunit biogenesis (GO:0042274)3.17697648
61mitotic sister chromatid segregation (GO:0000070)3.17095481
62spindle checkpoint (GO:0031577)3.16634653
63cytochrome complex assembly (GO:0017004)3.15636877
64protein complex biogenesis (GO:0070271)3.15346426
65RNA destabilization (GO:0050779)3.15071309
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12629898
67sister chromatid segregation (GO:0000819)3.11942026
68rRNA processing (GO:0006364)3.11176877
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10206863
70negative regulation of sister chromatid segregation (GO:0033046)3.10206863
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.10206863
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10206863
73nuclear pore organization (GO:0006999)3.10173689
74platelet dense granule organization (GO:0060155)3.08323118
75nuclear pore complex assembly (GO:0051292)3.07680044
76pseudouridine synthesis (GO:0001522)3.05711308
77transcription elongation from RNA polymerase III promoter (GO:0006385)3.05438159
78termination of RNA polymerase III transcription (GO:0006386)3.05438159
79regulation of spindle organization (GO:0090224)3.05244293
80postreplication repair (GO:0006301)3.04829298
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04536959
82negative regulation of chromosome segregation (GO:0051985)3.03714788
83respiratory chain complex IV assembly (GO:0008535)3.03680772
84rRNA metabolic process (GO:0016072)3.01428151
85DNA replication-dependent nucleosome assembly (GO:0006335)3.00894977
86DNA replication-dependent nucleosome organization (GO:0034723)3.00894977
87mitochondrial respiratory chain complex assembly (GO:0033108)2.99622475
88DNA ligation (GO:0006266)2.98438200
89positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98322463
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97470489
91regulation of B cell differentiation (GO:0045577)2.97418801
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96644280
93establishment of integrated proviral latency (GO:0075713)2.95271744
94regulation of double-strand break repair via homologous recombination (GO:0010569)2.94348596
95translational termination (GO:0006415)2.94252943
96regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93739138
97mitotic spindle checkpoint (GO:0071174)2.93540558
98regulation of alpha-beta T cell proliferation (GO:0046640)2.93167651
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92859334
100cellular response to interleukin-15 (GO:0071350)2.92332418
101nuclear envelope disassembly (GO:0051081)2.92021234
102membrane disassembly (GO:0030397)2.92021234
103spindle assembly checkpoint (GO:0071173)2.91584518
104viral transcription (GO:0019083)2.91408624
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90787566
106formation of translation preinitiation complex (GO:0001731)2.90003950
107telomere organization (GO:0032200)2.89794503
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89732116
109telomere maintenance (GO:0000723)2.89628226
110mitotic spindle assembly checkpoint (GO:0007094)2.88829584
111mismatch repair (GO:0006298)2.88626215
112regulation of chromosome segregation (GO:0051983)2.88553196
113chromatin assembly or disassembly (GO:0006333)2.88369624
114proteasome assembly (GO:0043248)2.87262998
115inositol phosphate catabolic process (GO:0071545)2.86199448
116spliceosomal snRNP assembly (GO:0000387)2.85894762
117ribosomal large subunit biogenesis (GO:0042273)2.85559387
118mast cell activation (GO:0045576)2.84052692
119regulation of mitotic sister chromatid segregation (GO:0033047)2.83361785
120regulation of sister chromatid segregation (GO:0033045)2.83361785
121regulation of mitotic sister chromatid separation (GO:0010965)2.83361785
122chromosome segregation (GO:0007059)2.82181643
123inositol phosphate dephosphorylation (GO:0046855)2.81738587
124phosphorylated carbohydrate dephosphorylation (GO:0046838)2.81738587
125protein localization to chromosome (GO:0034502)2.81185158
126regulation of centrosome cycle (GO:0046605)2.81015825
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80968133
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.80968133
129NADH dehydrogenase complex assembly (GO:0010257)2.80968133
130DNA topological change (GO:0006265)2.79983201
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79740920
132antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79373600
133response to interleukin-15 (GO:0070672)2.78876296
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78428079
135antigen processing and presentation of endogenous antigen (GO:0019883)2.76250071
136RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75479625
137neutrophil activation involved in immune response (GO:0002283)2.74699819
138positive T cell selection (GO:0043368)2.74596966
139positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73714403
140cytidine metabolic process (GO:0046087)2.71351668
141cytidine catabolic process (GO:0006216)2.71351668
142cytidine deamination (GO:0009972)2.71351668
143negative regulation of T cell mediated immunity (GO:0002710)2.62273401
144ketone body metabolic process (GO:1902224)2.62046497
145negative regulation of lymphocyte mediated immunity (GO:0002707)2.60434395
146Peyers patch development (GO:0048541)2.59803646
147mucosal-associated lymphoid tissue development (GO:0048537)2.59803646
148regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.59699268
149neutrophil activation (GO:0042119)2.55885559
150organelle disassembly (GO:1903008)2.53741264
151regulation of germinal center formation (GO:0002634)2.51031776
152protein K11-linked deubiquitination (GO:0035871)2.50420240
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.47850713
154positive regulation of DNA recombination (GO:0045911)2.47048222
155mast cell degranulation (GO:0043303)2.46549562
156mast cell activation involved in immune response (GO:0002279)2.46549562
157neural tube formation (GO:0001841)2.46268799
158ribonucleoprotein complex disassembly (GO:0032988)2.45709965
159cellular ketone body metabolic process (GO:0046950)2.45650720
160B cell receptor signaling pathway (GO:0050853)2.44731986
161T cell migration (GO:0072678)2.44110872
162DNA demethylation (GO:0080111)2.41962869
163regulation of B cell apoptotic process (GO:0002902)2.41214687
164pyrimidine ribonucleoside catabolic process (GO:0046133)2.41169858
165positive regulation of defense response to virus by host (GO:0002230)2.40528607
166production of molecular mediator involved in inflammatory response (GO:0002532)2.40076334
167rRNA catabolic process (GO:0016075)2.39416877
168immunoglobulin mediated immune response (GO:0016064)2.37282001
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37210232
170piRNA metabolic process (GO:0034587)2.35236503
171regulation of regulatory T cell differentiation (GO:0045589)2.35126255
172mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.34919916
173regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.34658608
174centriole replication (GO:0007099)2.33336263
175regulation of T cell mediated cytotoxicity (GO:0001914)2.32914098
176regulation of granulocyte differentiation (GO:0030852)2.32057059
177regulation of T cell receptor signaling pathway (GO:0050856)2.31627684
178water-soluble vitamin biosynthetic process (GO:0042364)2.31302266
179negative regulation of interleukin-1 beta production (GO:0032691)2.29131154
180leukocyte degranulation (GO:0043299)2.28824604
181somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.26839295
182somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.26839295
183isotype switching (GO:0045190)2.26839295
184positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.26516319
185purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.26438621
186granulocyte activation (GO:0036230)2.26280702
187preassembly of GPI anchor in ER membrane (GO:0016254)2.26021946
188T cell selection (GO:0045058)2.25852984
189negative regulation of phagocytosis (GO:0050765)2.23872371
190positive regulation of T cell mediated cytotoxicity (GO:0001916)2.23766816
191I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.22438976
192antigen receptor-mediated signaling pathway (GO:0050851)2.20287382
193regulation of leukocyte mediated cytotoxicity (GO:0001910)2.19860464
194regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.19737434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41462607
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.18827594
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03024282
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.00359610
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.99073370
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64065754
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35519124
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.18049745
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.16924513
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00582826
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80113425
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79487055
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78218831
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75242346
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68845574
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65631915
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.63849947
18VDR_22108803_ChIP-Seq_LS180_Human2.48643146
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45424366
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44450505
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44122488
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42748210
23* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38894415
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.36834624
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35308716
26VDR_23849224_ChIP-Seq_CD4+_Human2.34007856
27ZNF274_21170338_ChIP-Seq_K562_Hela2.28497448
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28062253
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25797488
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25533760
31AR_21909140_ChIP-Seq_LNCAP_Human2.25076653
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20690680
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18533523
34XRN2_22483619_ChIP-Seq_HELA_Human2.17353219
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14544925
36FOXP3_21729870_ChIP-Seq_TREG_Human2.14208727
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12677133
38E2F1_21310950_ChIP-Seq_MCF-7_Human2.10308158
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08456293
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.07415863
41DCP1A_22483619_ChIP-Seq_HELA_Human2.04187245
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01732553
43* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.98444901
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96882345
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94213170
46IGF1R_20145208_ChIP-Seq_DFB_Human1.93754066
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.93329811
48ELK1_19687146_ChIP-ChIP_HELA_Human1.92464334
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90465247
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81635634
51FUS_26573619_Chip-Seq_HEK293_Human1.81216983
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78470829
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.74887146
54TTF2_22483619_ChIP-Seq_HELA_Human1.71193105
55GABP_19822575_ChIP-Seq_HepG2_Human1.70751018
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69582271
57RUNX_20019798_ChIP-Seq_JUKART_Human1.69444200
58GATA3_26560356_Chip-Seq_TH2_Human1.68319939
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65600797
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64577237
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59522805
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57736996
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52985668
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50324832
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49817803
66ER_23166858_ChIP-Seq_MCF-7_Human1.48622875
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45228806
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44386651
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42470621
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41813038
71GATA3_27048872_Chip-Seq_THYMUS_Human1.39843007
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39255659
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39103404
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.35534711
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33783613
76MYB_26560356_Chip-Seq_TH1_Human1.29997717
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29957993
78TP53_22573176_ChIP-Seq_HFKS_Human1.28985795
79CIITA_25753668_ChIP-Seq_RAJI_Human1.27116782
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26339023
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26319642
82SCL_19346495_ChIP-Seq_HPC-7_Human1.23917154
83MYC_18940864_ChIP-ChIP_HL60_Human1.23403010
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23296836
85* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22223872
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22178334
87SPI1_23547873_ChIP-Seq_NB4_Human1.21640161
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.21273624
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.21114026
90* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20516618
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.19273173
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.16836572
93IRF1_19129219_ChIP-ChIP_H3396_Human1.14968886
94P300_19829295_ChIP-Seq_ESCs_Human1.14831288
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14116975
96CBP_20019798_ChIP-Seq_JUKART_Human1.14116975
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13782028
98TAF15_26573619_Chip-Seq_HEK293_Human1.13113281
99KDM5A_27292631_Chip-Seq_BREAST_Human1.12158700
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11916930
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11850816
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.11678191
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09944072
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07656839
105YY1_21170310_ChIP-Seq_MESCs_Mouse1.07629150
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06211049
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05346868
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.05346868
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04405961
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02634542
111AR_20517297_ChIP-Seq_VCAP_Human1.01303555
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00424867
113SALL4_22934838_ChIP-ChIP_CD34+_Human0.99323532
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98616544
115MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98253445
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98249626
117* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98216965
118FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96724067
119NANOG_19829295_ChIP-Seq_ESCs_Human0.95763273
120SOX2_19829295_ChIP-Seq_ESCs_Human0.95763273
121TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95721544
122CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95315638
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95235559
124MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94493714
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94307619
126ERG_20517297_ChIP-Seq_VCAP_Human0.91927676
127OCT4_18555785_Chip-Seq_ESCs_Mouse0.90707223
128* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90674257
129CRX_20693478_ChIP-Seq_RETINA_Mouse0.90381258
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89898462
131GATA3_26560356_Chip-Seq_TH1_Human0.88968189
132AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88539400
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88520570
134GATA1_22025678_ChIP-Seq_K562_Human0.88311224
135GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87365166
136IRF8_21731497_ChIP-ChIP_J774_Mouse0.83938696
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83015547
138STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80811297
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.80772501
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.80338678
141KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80022009
142CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77516918
143MYC_22102868_ChIP-Seq_BL_Human0.76697746
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75823695
145FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75648191
146PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73163603
147EWS_26573619_Chip-Seq_HEK293_Human0.72696361
148* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71966859
149SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71776540
150MYB_26560356_Chip-Seq_TH2_Human0.71339987
151TFEB_21752829_ChIP-Seq_HELA_Human0.68588733
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.67147399
153NANOG_21062744_ChIP-ChIP_HESCs_Human0.66166943
154FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65941647
155KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.65393092
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.63657524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.16299699
2MP0010094_abnormal_chromosome_stability4.76398756
3MP0003077_abnormal_cell_cycle3.72484475
4MP0004957_abnormal_blastocyst_morpholog3.67247007
5MP0003111_abnormal_nucleus_morphology3.64302950
6MP0008057_abnormal_DNA_replication3.27184593
7MP0002396_abnormal_hematopoietic_system3.26146967
8MP0008058_abnormal_DNA_repair3.17100632
9MP0008007_abnormal_cellular_replicative3.04027382
10MP0004147_increased_porphyrin_level2.55429479
11MP0008877_abnormal_DNA_methylation2.48339399
12MP0008932_abnormal_embryonic_tissue2.29174408
13MP0009697_abnormal_copulation2.21134922
14MP0006054_spinal_hemorrhage2.15824276
15MP0000685_abnormal_immune_system2.07431182
16MP0003195_calcinosis1.99857999
17MP0003718_maternal_effect1.94171279
18MP0004808_abnormal_hematopoietic_stem1.93838292
19MP0005084_abnormal_gallbladder_morpholo1.88533436
20MP0003763_abnormal_thymus_physiology1.82713295
21MP0000490_abnormal_crypts_of1.79845801
22MP0003123_paternal_imprinting1.76707475
23MP0005387_immune_system_phenotype1.76468553
24MP0001790_abnormal_immune_system1.76468553
25MP0006292_abnormal_olfactory_placode1.75991955
26MP0000569_abnormal_digit_pigmentation1.72423303
27MP0003806_abnormal_nucleotide_metabolis1.71231958
28MP0005075_abnormal_melanosome_morpholog1.68559458
29MP0001730_embryonic_growth_arrest1.68008231
30MP0003786_premature_aging1.66990389
31MP0000350_abnormal_cell_proliferation1.60959233
32MP0006072_abnormal_retinal_apoptosis1.59348344
33MP0002102_abnormal_ear_morphology1.58833277
34MP0005397_hematopoietic_system_phenotyp1.57974002
35MP0001545_abnormal_hematopoietic_system1.57974002
36MP0003787_abnormal_imprinting1.55818561
37MP0002210_abnormal_sex_determination1.49150347
38MP0002638_abnormal_pupillary_reflex1.44375745
39MP0005367_renal/urinary_system_phenotyp1.43628266
40MP0000516_abnormal_urinary_system1.43628266
41MP0001835_abnormal_antigen_presentation1.42844766
42MP0001929_abnormal_gametogenesis1.42453277
43MP0000566_synostosis1.40591477
44MP0002398_abnormal_bone_marrow1.40537652
45MP0010307_abnormal_tumor_latency1.37614077
46MP0005174_abnormal_tail_pigmentation1.36391208
47MP0003011_delayed_dark_adaptation1.35024934
48MP0001764_abnormal_homeostasis1.32972074
49MP0002928_abnormal_bile_duct1.32369734
50MP0009333_abnormal_splenocyte_physiolog1.31426812
51MP0000313_abnormal_cell_death1.30347184
52MP0002019_abnormal_tumor_incidence1.30035600
53MP0001145_abnormal_male_reproductive1.27998434
54MP0001697_abnormal_embryo_size1.26225793
55MP0005671_abnormal_response_to1.24876622
56MP0008872_abnormal_physiological_respon1.24198110
57MP0005379_endocrine/exocrine_gland_phen1.23592839
58MP0001919_abnormal_reproductive_system1.23490746
59MP0006082_CNS_inflammation1.23424647
60MP0001119_abnormal_female_reproductive1.22838321
61MP0000689_abnormal_spleen_morphology1.22320054
62MP0002722_abnormal_immune_system1.18940524
63MP0001845_abnormal_inflammatory_respons1.18717969
64MP0003866_abnormal_defecation1.18553388
65MP0003186_abnormal_redox_activity1.18383905
66MP0002095_abnormal_skin_pigmentation1.18338786
67MP0000653_abnormal_sex_gland1.17302143
68MP0000465_gastrointestinal_hemorrhage1.16328404
69MP0005408_hypopigmentation1.15715390
70MP0005380_embryogenesis_phenotype1.14998813
71MP0001672_abnormal_embryogenesis/_devel1.14998813
72MP0002277_abnormal_respiratory_mucosa1.14034226
73MP0000703_abnormal_thymus_morphology1.13521451
74MP0003567_abnormal_fetal_cardiomyocyte1.12847783
75MP0010234_abnormal_vibrissa_follicle1.12525103
76MP0005253_abnormal_eye_physiology1.12258475
77MP0002080_prenatal_lethality1.11625683
78MP0002429_abnormal_blood_cell1.11010200
79MP0006036_abnormal_mitochondrial_physio1.11006233
80MP0002138_abnormal_hepatobiliary_system1.10899133
81MP0009764_decreased_sensitivity_to1.07857935
82MP0003315_abnormal_perineum_morphology1.07784111
83MP0002163_abnormal_gland_morphology1.07605423
84MP0003943_abnormal_hepatobiliary_system1.06087092
85MP0003984_embryonic_growth_retardation1.05868269
86MP0000716_abnormal_immune_system1.05584224
87MP0002006_tumorigenesis1.05488805
88MP0010155_abnormal_intestine_physiology1.05283693
89MP0010352_gastrointestinal_tract_polyps1.05219385
90MP0000372_irregular_coat_pigmentation1.03863086
91MP0002452_abnormal_antigen_presenting1.02382009
92MP0002420_abnormal_adaptive_immunity1.02011171
93MP0002693_abnormal_pancreas_physiology1.01447555
94MP0004381_abnormal_hair_follicle1.01044434
95MP0002088_abnormal_embryonic_growth/wei1.00526402
96MP0003121_genomic_imprinting0.99963623
97MP0008961_abnormal_basal_metabolism0.99737613
98MP0003252_abnormal_bile_duct0.99660374
99MP0001800_abnormal_humoral_immune0.99514511
100MP0001819_abnormal_immune_cell0.98732895
101MP0001529_abnormal_vocalization0.98710101
102MP0005310_abnormal_salivary_gland0.98497589
103MP0008875_abnormal_xenobiotic_pharmacok0.98374061
104MP0001293_anophthalmia0.98140240
105MP0008469_abnormal_protein_level0.97830077
106MP0005646_abnormal_pituitary_gland0.95910727
107MP0001984_abnormal_olfaction0.95631044
108MP0008995_early_reproductive_senescence0.94258478
109MP0005551_abnormal_eye_electrophysiolog0.94251509
110MP0001501_abnormal_sleep_pattern0.93812260
111MP0004043_abnormal_pH_regulation0.93812210
112MP0002938_white_spotting0.91741366
113MP0009785_altered_susceptibility_to0.91227616
114MP0003878_abnormal_ear_physiology0.91142983
115MP0005377_hearing/vestibular/ear_phenot0.91142983
116MP0001853_heart_inflammation0.89651229
117MP0009765_abnormal_xenobiotic_induced0.89510721
118MP0002085_abnormal_embryonic_tissue0.88659859
119MP0003698_abnormal_male_reproductive0.88616453
120MP0006035_abnormal_mitochondrial_morpho0.88206536
121MP0003656_abnormal_erythrocyte_physiolo0.87581767
122MP0005464_abnormal_platelet_physiology0.86433667
123MP0002837_dystrophic_cardiac_calcinosis0.85053945
124MP0005645_abnormal_hypothalamus_physiol0.84491085
125MP0003303_peritoneal_inflammation0.84294619
126MP0002405_respiratory_system_inflammati0.83759793
127MP0002009_preneoplasia0.83674139
128MP0002723_abnormal_immune_serum0.83469668
129MP0002084_abnormal_developmental_patter0.83348341
130MP0005410_abnormal_fertilization0.82814993
131MP0003699_abnormal_female_reproductive0.82708665
132MP0005085_abnormal_gallbladder_physiolo0.82579475
133MP0000427_abnormal_hair_cycle0.82087976
134MP0000015_abnormal_ear_pigmentation0.82075403
135MP0001188_hyperpigmentation0.81834486
136MP0002086_abnormal_extraembryonic_tissu0.81701785
137MP0003724_increased_susceptibility_to0.81456975
138MP0001986_abnormal_taste_sensitivity0.81328665
139MP0002148_abnormal_hypersensitivity_rea0.80072444
140MP0005000_abnormal_immune_tolerance0.79665678
141MP0005025_abnormal_response_to0.78256320
142MP0002419_abnormal_innate_immunity0.77606122
143MP0000371_diluted_coat_color0.77595566
144MP0002132_abnormal_respiratory_system0.76507338
145MP0003890_abnormal_embryonic-extraembry0.75889459
146MP0004197_abnormal_fetal_growth/weight/0.74515778
147MP0002075_abnormal_coat/hair_pigmentati0.71546099
148MP0003436_decreased_susceptibility_to0.71382865
149MP0000858_altered_metastatic_potential0.71375974
150MP0002160_abnormal_reproductive_system0.71267946
151MP0005389_reproductive_system_phenotype0.71125413
152MP0003937_abnormal_limbs/digits/tail_de0.70898723
153MP0002161_abnormal_fertility/fecundity0.70184562
154MP0002166_altered_tumor_susceptibility0.68529634

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.16603941
2Birth length less than 3rd percentile (HP:0003561)3.65246687
3Oral leukoplakia (HP:0002745)3.61446853
4Reticulocytopenia (HP:0001896)3.59009281
5Chromsome breakage (HP:0040012)3.53880170
6Abnormal number of erythroid precursors (HP:0012131)3.53620559
7Stomatitis (HP:0010280)3.45558105
8Abnormality of cells of the erythroid lineage (HP:0012130)3.37657469
9Abnormality of chromosome stability (HP:0003220)3.16745717
10IgG deficiency (HP:0004315)3.08810510
11Severe combined immunodeficiency (HP:0004430)3.05301744
12T lymphocytopenia (HP:0005403)3.00424859
13Abnormality of T cell number (HP:0011839)2.99871172
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97895514
15Mitochondrial inheritance (HP:0001427)2.97316903
1611 pairs of ribs (HP:0000878)2.97120646
17Myelodysplasia (HP:0002863)2.91423601
18Thyroiditis (HP:0100646)2.90861163
19Renal cortical cysts (HP:0000803)2.90784924
20Breast hypoplasia (HP:0003187)2.84772535
21Patellar aplasia (HP:0006443)2.81974891
22Increased CSF lactate (HP:0002490)2.80782290
23Abnormality of the renal cortex (HP:0011035)2.80337003
24IgM deficiency (HP:0002850)2.77889351
25Abnormality of the preputium (HP:0100587)2.73486762
26Abnormality of T cells (HP:0002843)2.71887382
27Progressive macrocephaly (HP:0004481)2.71725995
28Acute necrotizing encephalopathy (HP:0006965)2.67916834
29Abnormality of the anterior horn cell (HP:0006802)2.67768850
30Degeneration of anterior horn cells (HP:0002398)2.67768850
31Bone marrow hypocellularity (HP:0005528)2.66202639
32Elevated erythrocyte sedimentation rate (HP:0003565)2.64845509
33Microvesicular hepatic steatosis (HP:0001414)2.64109919
34Hepatocellular necrosis (HP:0001404)2.63728315
35Acute myeloid leukemia (HP:0004808)2.63347024
36Aplasia/Hypoplasia of the patella (HP:0006498)2.61898785
37Colon cancer (HP:0003003)2.61193905
38Pancreatic cysts (HP:0001737)2.60131076
39Thrombocytosis (HP:0001894)2.59347865
40Meckel diverticulum (HP:0002245)2.58208423
41Abnormality of the ileum (HP:0001549)2.56390645
42Encephalitis (HP:0002383)2.55919723
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.55681842
44Abnormality of the prostate (HP:0008775)2.54897928
45Agnosia (HP:0010524)2.54200853
46Optic neuritis (HP:0100653)2.53753087
47Retrobulbar optic neuritis (HP:0100654)2.53753087
48Hypochromic microcytic anemia (HP:0004840)2.52147281
49Abnormal spermatogenesis (HP:0008669)2.52115477
50Lymphoma (HP:0002665)2.51292577
51Myositis (HP:0100614)2.51128420
52Congenital stationary night blindness (HP:0007642)2.50434503
53Duodenal stenosis (HP:0100867)2.50098039
54Small intestinal stenosis (HP:0012848)2.50098039
55Type I transferrin isoform profile (HP:0003642)2.49923269
56Abnormal lung lobation (HP:0002101)2.49841259
57Hepatic necrosis (HP:0002605)2.49118117
58Lipid accumulation in hepatocytes (HP:0006561)2.49108145
59Combined immunodeficiency (HP:0005387)2.47213357
60Premature graying of hair (HP:0002216)2.45279175
61Abnormality of midbrain morphology (HP:0002418)2.44390556
62Molar tooth sign on MRI (HP:0002419)2.44390556
63B lymphocytopenia (HP:0010976)2.43628579
64Abnormality of B cell number (HP:0010975)2.43628579
65Ectopic kidney (HP:0000086)2.41476380
66Reduced antithrombin III activity (HP:0001976)2.40762194
67Abnormality of lateral ventricle (HP:0030047)2.40558435
68Attenuation of retinal blood vessels (HP:0007843)2.40537435
69Rough bone trabeculation (HP:0100670)2.40404514
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.39780013
71Methylmalonic acidemia (HP:0002912)2.39321915
72Impulsivity (HP:0100710)2.37531999
73Abnormality of the labia minora (HP:0012880)2.36340372
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36064215
75Syringomyelia (HP:0003396)2.35960503
76Spinal cord lesions (HP:0100561)2.35960503
77Abnormality of T cell physiology (HP:0011840)2.35238127
78Recurrent fungal infections (HP:0002841)2.34927539
79Abnormal mitochondria in muscle tissue (HP:0008316)2.34046849
80Aplasia/hypoplasia of the uterus (HP:0008684)2.32195924
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31953224
82Abnormal rod and cone electroretinograms (HP:0008323)2.31254843
83Abnormality of the duodenum (HP:0002246)2.30953400
84Carpal bone hypoplasia (HP:0001498)2.30706603
85Abnormal biliary tract physiology (HP:0012439)2.28053417
86Bile duct proliferation (HP:0001408)2.28053417
87Chronic hepatic failure (HP:0100626)2.26511551
88Sloping forehead (HP:0000340)2.25340448
89Recurrent bacterial skin infections (HP:0005406)2.24789486
90Abnormality of eosinophils (HP:0001879)2.22487702
91Acute encephalopathy (HP:0006846)2.20724662
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20673121
93Abolished electroretinogram (ERG) (HP:0000550)2.20607437
94Prostate neoplasm (HP:0100787)2.18847961
95Medulloblastoma (HP:0002885)2.17669645
96Pulmonary fibrosis (HP:0002206)2.17326470
97Pallor (HP:0000980)2.14127905
98Supernumerary spleens (HP:0009799)2.13175342
99Volvulus (HP:0002580)2.12363010
100Abnormal protein glycosylation (HP:0012346)2.12336885
101Abnormal glycosylation (HP:0012345)2.12336885
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12336885
103Abnormal protein N-linked glycosylation (HP:0012347)2.12336885
104Autoimmune hemolytic anemia (HP:0001890)2.11564754
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11143347
106Cortical dysplasia (HP:0002539)2.10666847
107Poor head control (HP:0002421)2.10435273
108Absent forearm bone (HP:0003953)2.09819674
109Aplasia involving forearm bones (HP:0009822)2.09819674
110Type 2 muscle fiber atrophy (HP:0003554)2.08135522
111Increased intramyocellular lipid droplets (HP:0012240)2.07982306
112Pancytopenia (HP:0001876)2.07522051
113Abnormality of the heme biosynthetic pathway (HP:0010472)2.07217739
114Hematochezia (HP:0002573)2.06408437
115Progressive inability to walk (HP:0002505)2.05386410
116Horseshoe kidney (HP:0000085)2.04701791
117Congenital, generalized hypertrichosis (HP:0004540)2.04464596
118Renal Fanconi syndrome (HP:0001994)2.04357929
119Nephronophthisis (HP:0000090)2.04313578
120Nephroblastoma (Wilms tumor) (HP:0002667)2.03707322
121Recurrent abscess formation (HP:0002722)2.03565269
122Muscle fiber atrophy (HP:0100295)2.03420690
123Congenital sensorineural hearing impairment (HP:0008527)2.03097891
124Triphalangeal thumb (HP:0001199)2.02431881
125Chronic mucocutaneous candidiasis (HP:0002728)2.01352241
126Recurrent cutaneous fungal infections (HP:0011370)2.01352241
127Constricted visual fields (HP:0001133)2.00833864
128Orchitis (HP:0100796)2.00563078
129Selective tooth agenesis (HP:0001592)2.00490098
130Petechiae (HP:0000967)2.00047401
131Diastasis recti (HP:0001540)1.99472965
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99221585
133Absent radius (HP:0003974)1.98292991
134Mediastinal lymphadenopathy (HP:0100721)1.97910252
135Hypoplasia of the radius (HP:0002984)1.97734198
136Increased serum lactate (HP:0002151)1.97647807
137Neutropenia (HP:0001875)1.96961014
138Cellular immunodeficiency (HP:0005374)1.96534789
139Absent thumb (HP:0009777)1.95788746
140Pancreatic fibrosis (HP:0100732)1.95585325
141Eosinophilia (HP:0001880)1.95086203
142Methylmalonic aciduria (HP:0012120)1.94757718
143Recurrent viral infections (HP:0004429)1.94736408
144Stenosis of the external auditory canal (HP:0000402)1.94548539
145Clubbing of toes (HP:0100760)1.93811602
146Irregular epiphyses (HP:0010582)1.92222956
147Amaurosis fugax (HP:0100576)1.91580185
148Microretrognathia (HP:0000308)1.91465297
149Macrocytic anemia (HP:0001972)1.89995125
150Embryonal renal neoplasm (HP:0011794)1.89952532
151Abnormality of the renal medulla (HP:0100957)1.89811164
152Ketosis (HP:0001946)1.89333007
153Cerebral edema (HP:0002181)1.88884962
154Abnormality of the columella (HP:0009929)1.88283120
155Meningitis (HP:0001287)1.85853604
156Keratoconjunctivitis sicca (HP:0001097)1.85552205
1573-Methylglutaconic aciduria (HP:0003535)1.85423165
158Neoplasm of the adrenal cortex (HP:0100641)1.85422578
159Exertional dyspnea (HP:0002875)1.84585844
160Stomach cancer (HP:0012126)1.84569515
161Keratoconjunctivitis (HP:0001096)1.84214307
162Hypoplasia of the thymus (HP:0000778)1.83820008
163Medial flaring of the eyebrow (HP:0010747)1.82215625
164Lactic acidosis (HP:0003128)1.81381512
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81163363
166Leukocytosis (HP:0001974)1.79952254
167Hypoplasia of the uterus (HP:0000013)1.79923500
168Abnormal trabecular bone morphology (HP:0100671)1.79375876
169Recurrent skin infections (HP:0001581)1.79006715
170Optic disc pallor (HP:0000543)1.78587899
171Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78272399
172Dyschromatopsia (HP:0007641)1.78044941
173Respiratory difficulties (HP:0002880)1.77722867
174True hermaphroditism (HP:0010459)1.75753582
175Hypochromic anemia (HP:0001931)1.75656415
176Lymphopenia (HP:0001888)1.74927761
177Vasculitis (HP:0002633)1.74439903
178Cleft eyelid (HP:0000625)1.74311894
179Abnormality of vitamin B metabolism (HP:0004340)1.73121903
180Granulocytopenia (HP:0001913)1.72484295
181Increased hepatocellular lipid droplets (HP:0006565)1.71784260
182Hypoproteinemia (HP:0003075)1.71614157
183Increased muscle lipid content (HP:0009058)1.71466651
184Cutaneous melanoma (HP:0012056)1.70063332
185Panhypogammaglobulinemia (HP:0003139)1.68335707
186Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67156205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.48210122
2CDC73.73654037
3EIF2AK13.58932724
4BUB13.47906348
5WEE13.16507799
6SRPK13.09825679
7MKNK12.87340714
8PLK42.86336589
9PBK2.59809682
10STK162.51394364
11NME12.40088462
12VRK12.28809121
13NEK22.23019518
14MKNK22.22190682
15BRSK22.16299808
16TTK1.96719333
17GRK61.86444945
18TSSK61.82118701
19ATR1.79902596
20PLK11.74313280
21ITK1.73976023
22EIF2AK31.69225188
23BLK1.60243011
24TNK21.57626319
25CDK81.57216675
26FGFR31.55178864
27IKBKE1.54175501
28ACVR1B1.54057736
29PASK1.52352634
30AURKB1.52103842
31NME21.50729163
32VRK21.49781646
33BMPR1B1.49673701
34STK101.48635912
35PLK31.45682690
36BRAF1.42480869
37CCNB11.39289435
38CHEK21.36776988
39TEC1.35526549
40TAF11.34108131
41CDK71.34028662
42CAMKK21.33553713
43INSRR1.32065776
44PIM21.31109305
45MARK31.27813630
46BRSK11.24849270
47RIPK41.24034625
48DYRK31.22678051
49MAP4K21.20410860
50MST41.18365497
51BRD41.18101635
52FES1.10554923
53RPS6KA41.06674972
54PIM11.05400613
55WNK31.04299980
56MAP4K11.03681771
57KIT1.03282502
58TLK11.00876182
59PRKCQ1.00499835
60MAP3K80.99116548
61PDK20.97357732
62LCK0.94223837
63MAP3K40.94085635
64AKT30.93458207
65IRAK10.93383966
66BCKDK0.93147121
67SIK30.92348831
68STK40.92175101
69GRK10.91143111
70TESK20.90883716
71AURKA0.90061431
72MAPK130.89527405
73RPS6KB20.89323530
74FGFR20.89259989
75PDK40.88851028
76PDK30.88851028
77TGFBR10.88447684
78ZAK0.87920797
79MUSK0.87623997
80TRIM280.87336026
81IRAK40.85271348
82MAP3K140.85127958
83MAP3K130.85064808
84PINK10.84949356
85ERBB30.83261028
86ATM0.82730855
87MELK0.80650974
88JAK30.80129207
89EIF2AK20.80087336
90CHEK10.79868112
91BTK0.78059243
92CDK40.77807979
93FLT30.77319404
94PIK3CG0.76543907
95MAP3K120.75402508
96OXSR10.75381783
97TXK0.74610049
98SIK20.73943700
99TBK10.71939387
100TAOK30.71109363
101MAP2K60.70635569
102HCK0.69399320
103JAK10.69273222
104TESK10.63215403
105DYRK20.63089395
106RAF10.62300716
107ERBB40.62150817
108MAP2K70.61753929
109NUAK10.58532079
110STK30.57882141
111CSK0.57126285
112CAMKK10.56253762
113CSNK2A10.54714972
114LYN0.54532964
115CLK10.54337144
116CDK190.53280504
117CDK20.52857752
118YES10.52229551
119DYRK1A0.50541419
120MAPKAPK50.49318583
121NEK90.48320594
122CSNK2A20.48187804
123ABL10.47349332
124RPS6KA50.46191263
125CSF1R0.45771169
126CSNK1G30.45651576
127CDK10.45580999
128MATK0.44340057
129LRRK20.43844317
130KDR0.42779473
131CHUK0.42741560
132ADRBK20.42691748
133CDK60.42123653
134NEK10.42005909
135LIMK10.41139165
136NLK0.40463509
137BMPR20.39276243
138MAP3K60.38393198
139ZAP700.37829790
140SYK0.37342118
141GRK70.37222768
142ADRBK10.36010907
143CSNK1G10.35911969
144CSNK1G20.35648012
145FGR0.34314265
146IKBKB0.33103137
147TYK20.31787008
148STK38L0.30827884
149PAK10.30237513
150BCR0.29769338
151EEF2K0.28600551

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.89523014
2Mismatch repair_Homo sapiens_hsa034304.06648698
3RNA polymerase_Homo sapiens_hsa030203.44230138
4Homologous recombination_Homo sapiens_hsa034403.36200873
5Base excision repair_Homo sapiens_hsa034103.14730016
6Ribosome_Homo sapiens_hsa030103.13139566
7Spliceosome_Homo sapiens_hsa030403.13035776
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10352661
9Non-homologous end-joining_Homo sapiens_hsa034502.88658684
10Proteasome_Homo sapiens_hsa030502.87891401
11Cell cycle_Homo sapiens_hsa041102.81048283
12Graft-versus-host disease_Homo sapiens_hsa053322.78285954
13RNA transport_Homo sapiens_hsa030132.70011824
14Pyrimidine metabolism_Homo sapiens_hsa002402.68942492
15Autoimmune thyroid disease_Homo sapiens_hsa053202.58074645
16Nucleotide excision repair_Homo sapiens_hsa034202.49052845
17Type I diabetes mellitus_Homo sapiens_hsa049402.45968856
18Oxidative phosphorylation_Homo sapiens_hsa001902.45909078
19Fanconi anemia pathway_Homo sapiens_hsa034602.38510946
20One carbon pool by folate_Homo sapiens_hsa006702.37772887
21RNA degradation_Homo sapiens_hsa030182.23620034
22Basal transcription factors_Homo sapiens_hsa030222.14658545
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11308769
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86631935
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72575667
26Protein export_Homo sapiens_hsa030601.68295802
27Purine metabolism_Homo sapiens_hsa002301.57540566
28p53 signaling pathway_Homo sapiens_hsa041151.55159168
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52694850
30mRNA surveillance pathway_Homo sapiens_hsa030151.47282173
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43699355
32Regulation of autophagy_Homo sapiens_hsa041401.42114650
33Phototransduction_Homo sapiens_hsa047441.40784911
34Rheumatoid arthritis_Homo sapiens_hsa053231.32101091
35Herpes simplex infection_Homo sapiens_hsa051681.26643530
36Alzheimers disease_Homo sapiens_hsa050101.19846755
37Staphylococcus aureus infection_Homo sapiens_hsa051501.13669736
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.13163553
39Systemic lupus erythematosus_Homo sapiens_hsa053221.10835875
40Epstein-Barr virus infection_Homo sapiens_hsa051691.09910446
41Butanoate metabolism_Homo sapiens_hsa006501.07428272
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97970896
43Circadian rhythm_Homo sapiens_hsa047100.93556790
44Selenocompound metabolism_Homo sapiens_hsa004500.92921331
45Folate biosynthesis_Homo sapiens_hsa007900.91931577
46Propanoate metabolism_Homo sapiens_hsa006400.90715597
47T cell receptor signaling pathway_Homo sapiens_hsa046600.90141989
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89232431
49Peroxisome_Homo sapiens_hsa041460.86713295
50Legionellosis_Homo sapiens_hsa051340.85980788
51Caffeine metabolism_Homo sapiens_hsa002320.85717626
52Oocyte meiosis_Homo sapiens_hsa041140.84007071
53N-Glycan biosynthesis_Homo sapiens_hsa005100.83471482
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80806149
55Antigen processing and presentation_Homo sapiens_hsa046120.78839027
56Tuberculosis_Homo sapiens_hsa051520.76519861
57Primary immunodeficiency_Homo sapiens_hsa053400.74778922
58Tryptophan metabolism_Homo sapiens_hsa003800.73683600
59Pentose phosphate pathway_Homo sapiens_hsa000300.72888198
60Sulfur metabolism_Homo sapiens_hsa009200.72697369
61Hematopoietic cell lineage_Homo sapiens_hsa046400.72193973
62Thyroid cancer_Homo sapiens_hsa052160.67433833
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67142899
64Viral carcinogenesis_Homo sapiens_hsa052030.67038803
65Ether lipid metabolism_Homo sapiens_hsa005650.66906612
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66850350
67Measles_Homo sapiens_hsa051620.66166571
68Osteoclast differentiation_Homo sapiens_hsa043800.66106625
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65327707
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65241002
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64339251
72Viral myocarditis_Homo sapiens_hsa054160.63628129
73Collecting duct acid secretion_Homo sapiens_hsa049660.62741544
74Nitrogen metabolism_Homo sapiens_hsa009100.62383356
75Vitamin B6 metabolism_Homo sapiens_hsa007500.62358878
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62340231
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.60212839
78Shigellosis_Homo sapiens_hsa051310.59909186
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.57591541
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57220190
81HTLV-I infection_Homo sapiens_hsa051660.56909379
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54909968
83Chemical carcinogenesis_Homo sapiens_hsa052040.53472152
84MicroRNAs in cancer_Homo sapiens_hsa052060.52919618
85Hepatitis B_Homo sapiens_hsa051610.52174537
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51964346
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50703456
88Glutathione metabolism_Homo sapiens_hsa004800.49444364
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49225276
90Arachidonic acid metabolism_Homo sapiens_hsa005900.48424461
91Olfactory transduction_Homo sapiens_hsa047400.47586901
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46844398
93Huntingtons disease_Homo sapiens_hsa050160.43355658
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43286202
95Taste transduction_Homo sapiens_hsa047420.42791631
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.42472622
97African trypanosomiasis_Homo sapiens_hsa051430.42439690
98Influenza A_Homo sapiens_hsa051640.42047516
99Retinol metabolism_Homo sapiens_hsa008300.41884770
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41400204
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.41317323
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.40673261
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39489284
104Leishmaniasis_Homo sapiens_hsa051400.38563246
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38316904
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38197962
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37087621
108Allograft rejection_Homo sapiens_hsa053300.36779486
109Apoptosis_Homo sapiens_hsa042100.36373534
110ABC transporters_Homo sapiens_hsa020100.36299537
111Asthma_Homo sapiens_hsa053100.35864175
112Small cell lung cancer_Homo sapiens_hsa052220.35539997
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34272878
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33116464
115Alcoholism_Homo sapiens_hsa050340.32398391
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31745813
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25656975
118TGF-beta signaling pathway_Homo sapiens_hsa043500.25473816
119Metabolic pathways_Homo sapiens_hsa011000.24907858
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24606142
121Linoleic acid metabolism_Homo sapiens_hsa005910.22374419
122Biosynthesis of amino acids_Homo sapiens_hsa012300.21784118
123B cell receptor signaling pathway_Homo sapiens_hsa046620.21769169
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.20513388
125Malaria_Homo sapiens_hsa051440.19777165
126Sulfur relay system_Homo sapiens_hsa041220.19391319
127Acute myeloid leukemia_Homo sapiens_hsa052210.18906768
128Sphingolipid metabolism_Homo sapiens_hsa006000.18729168
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18455461
130Pancreatic cancer_Homo sapiens_hsa052120.18089487
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16289218
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14355667
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.13187084
134Parkinsons disease_Homo sapiens_hsa050120.13157680
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12829063
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12228560
137Prostate cancer_Homo sapiens_hsa052150.11904229
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.11780683
139Colorectal cancer_Homo sapiens_hsa052100.11760675
140Pathways in cancer_Homo sapiens_hsa052000.10963202
141Bladder cancer_Homo sapiens_hsa052190.10333891
142Toxoplasmosis_Homo sapiens_hsa051450.10061427
143Pertussis_Homo sapiens_hsa051330.09713731

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