ANKRD54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.45445744
2fusion of sperm to egg plasma membrane (GO:0007342)6.24988577
3sperm motility (GO:0030317)6.07599375
4sperm-egg recognition (GO:0035036)5.86563193
5axonemal dynein complex assembly (GO:0070286)5.82721048
6binding of sperm to zona pellucida (GO:0007339)5.70328989
7DNA deamination (GO:0045006)5.66734313
8motile cilium assembly (GO:0044458)5.54176142
9behavioral response to nicotine (GO:0035095)5.51778137
10piRNA metabolic process (GO:0034587)5.28823801
11acrosome assembly (GO:0001675)5.27940643
12cell-cell recognition (GO:0009988)5.20364527
13spermatid development (GO:0007286)5.05667689
14cell wall macromolecule catabolic process (GO:0016998)4.93302441
15cell wall macromolecule metabolic process (GO:0044036)4.93302441
16acrosome reaction (GO:0007340)4.88217699
17axoneme assembly (GO:0035082)4.80171697
18epithelial cilium movement (GO:0003351)4.63426391
19multicellular organism reproduction (GO:0032504)4.60856362
20male meiosis (GO:0007140)4.54367849
21plasma membrane fusion (GO:0045026)4.49465094
22base-excision repair, AP site formation (GO:0006285)4.44389591
23synaptonemal complex organization (GO:0070193)4.38801164
24centriole replication (GO:0007099)4.38091822
25regulation of cilium movement (GO:0003352)4.37840725
26synaptonemal complex assembly (GO:0007130)4.22173742
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.09559091
28male meiosis I (GO:0007141)3.94237395
29reproduction (GO:0000003)3.88865546
30protein polyglutamylation (GO:0018095)3.88509074
31cilium movement (GO:0003341)3.87090437
32negative regulation of telomere maintenance (GO:0032205)3.82596899
33pyrimidine nucleobase catabolic process (GO:0006208)3.77327810
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.65749924
35meiosis I (GO:0007127)3.62209969
36protein complex biogenesis (GO:0070271)3.61198610
37DNA methylation involved in gamete generation (GO:0043046)3.60721602
38DNA strand elongation involved in DNA replication (GO:0006271)3.58881898
39respiratory chain complex IV assembly (GO:0008535)3.54865680
40DNA strand elongation (GO:0022616)3.53323356
41gamma-aminobutyric acid transport (GO:0015812)3.51104694
42meiotic nuclear division (GO:0007126)3.49220091
43protein localization to cilium (GO:0061512)3.48061453
44cilium morphogenesis (GO:0060271)3.47782552
45telomere maintenance via semi-conservative replication (GO:0032201)3.46225791
46ubiquinone biosynthetic process (GO:0006744)3.45498049
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42871542
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.42871542
49NADH dehydrogenase complex assembly (GO:0010257)3.42871542
50single fertilization (GO:0007338)3.40356792
51thalamus development (GO:0021794)3.38876758
52cytochrome complex assembly (GO:0017004)3.35673451
53chromosome organization involved in meiosis (GO:0070192)3.32620845
54spermatogenesis (GO:0007283)3.30666728
55translesion synthesis (GO:0019985)3.30466773
56male gamete generation (GO:0048232)3.30340218
57cilium organization (GO:0044782)3.29635068
58mannosylation (GO:0097502)3.29404953
59ubiquinone metabolic process (GO:0006743)3.26865515
60mitochondrial respiratory chain complex assembly (GO:0033108)3.23935135
61cilium assembly (GO:0042384)3.21188105
62ribosomal small subunit assembly (GO:0000028)3.18190508
63left/right pattern formation (GO:0060972)3.15810307
64seminiferous tubule development (GO:0072520)3.15233091
65nonmotile primary cilium assembly (GO:0035058)3.14869815
66negative regulation of inclusion body assembly (GO:0090084)3.12709518
67response to misfolded protein (GO:0051788)3.12493715
68DNA packaging (GO:0006323)3.09201379
69pyrimidine dimer repair (GO:0006290)3.07602273
70preassembly of GPI anchor in ER membrane (GO:0016254)3.07395093
71microtubule depolymerization (GO:0007019)3.06700807
72nucleobase catabolic process (GO:0046113)3.05447825
73chromosome condensation (GO:0030261)3.04114672
74telomere maintenance via recombination (GO:0000722)3.03010615
75protein localization to chromosome, centromeric region (GO:0071459)3.02988890
76fertilization (GO:0009566)3.02233117
77gamete generation (GO:0007276)3.01121997
78organic cation transport (GO:0015695)3.00278500
79antigen processing and presentation via MHC class Ib (GO:0002475)2.99725200
80meiotic cell cycle (GO:0051321)2.99092325
81Golgi transport vesicle coating (GO:0048200)2.96763702
82COPI coating of Golgi vesicle (GO:0048205)2.96763702
83synaptic transmission, cholinergic (GO:0007271)2.95932318
84centriole assembly (GO:0098534)2.95247667
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94793276
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.94691028
87ventricular system development (GO:0021591)2.93410686
88DNA replication initiation (GO:0006270)2.93208382
89fucose catabolic process (GO:0019317)2.89141816
90L-fucose metabolic process (GO:0042354)2.89141816
91L-fucose catabolic process (GO:0042355)2.89141816
92postsynaptic membrane organization (GO:0001941)2.85608865
93signal peptide processing (GO:0006465)2.83576929
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82259589
95negative regulation of response to food (GO:0032096)2.82076376
96negative regulation of appetite (GO:0032099)2.82076376
97protein-cofactor linkage (GO:0018065)2.82059194
98germ cell development (GO:0007281)2.81998483
99protoporphyrinogen IX biosynthetic process (GO:0006782)2.81900649
100DNA replication-dependent nucleosome organization (GO:0034723)2.79720872
101DNA replication-dependent nucleosome assembly (GO:0006335)2.79720872
102regulation of inclusion body assembly (GO:0090083)2.79637403
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78450209
104glycerol ether metabolic process (GO:0006662)2.78443554
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75977305
106sperm capacitation (GO:0048240)2.75085200
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74166676
108positive regulation of prostaglandin secretion (GO:0032308)2.72026033
109histone exchange (GO:0043486)2.71857403
110RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71535824
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71535824
112mitotic recombination (GO:0006312)2.71531280
113GPI anchor metabolic process (GO:0006505)2.71334792
114antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71215867
115antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71215867
116intra-S DNA damage checkpoint (GO:0031573)2.70200294
117N-acetylglucosamine metabolic process (GO:0006044)2.69166561
118quinone biosynthetic process (GO:1901663)2.68606383
119ATP synthesis coupled proton transport (GO:0015986)2.68213893
120energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68213893
121regulation of chromatin binding (GO:0035561)2.66647079
122microtubule bundle formation (GO:0001578)2.66529431
123histone H2A acetylation (GO:0043968)2.65560590
124cellular process involved in reproduction in multicellular organism (GO:0022412)2.65351801
125amino acid salvage (GO:0043102)2.64313422
126L-methionine salvage (GO:0071267)2.64313422
127L-methionine biosynthetic process (GO:0071265)2.64313422
128cotranslational protein targeting to membrane (GO:0006613)2.63848390
129regulation of mitochondrial translation (GO:0070129)2.63816135
130reciprocal DNA recombination (GO:0035825)2.63587150
131reciprocal meiotic recombination (GO:0007131)2.63587150
132protein targeting to ER (GO:0045047)2.62995024
133meiotic cell cycle process (GO:1903046)2.62932890
134sequestering of actin monomers (GO:0042989)2.61272956
135response to pheromone (GO:0019236)2.61117933
136protein-DNA complex disassembly (GO:0032986)2.60664697
137nucleosome disassembly (GO:0006337)2.60664697
138energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.60031034
139ATP hydrolysis coupled proton transport (GO:0015991)2.60031034
140GTP biosynthetic process (GO:0006183)2.59896511
141GDP-mannose metabolic process (GO:0019673)2.59873117
142positive regulation of oligodendrocyte differentiation (GO:0048714)2.59383060
143intraciliary transport (GO:0042073)2.57768105
144gene silencing by RNA (GO:0031047)2.57578202
145guanosine-containing compound biosynthetic process (GO:1901070)2.57570135
146endosome to pigment granule transport (GO:0043485)2.57191986
147endosome to melanosome transport (GO:0035646)2.57191986
148pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.55321873
149regulation of microtubule-based movement (GO:0060632)2.55098413
150platelet dense granule organization (GO:0060155)2.55061176
151positive regulation of mitochondrial fission (GO:0090141)2.54754779
152regulation of spindle checkpoint (GO:0090231)2.54201912
153pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.54086533
154mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53411673
155telomere maintenance via telomere lengthening (GO:0010833)2.53125979
156chaperone-mediated protein transport (GO:0072321)2.52032183
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51639557
158protein refolding (GO:0042026)2.51458261
159ether metabolic process (GO:0018904)2.51160210
160protein localization to endoplasmic reticulum (GO:0070972)2.50552363
161electron transport chain (GO:0022900)2.49572642
162nucleotide-excision repair, DNA gap filling (GO:0006297)2.49493850
163regulation of synapse structural plasticity (GO:0051823)2.48516524
164single strand break repair (GO:0000012)2.47668711
165pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.46387651
166establishment of protein localization to endoplasmic reticulum (GO:0072599)2.46344714
167protein deneddylation (GO:0000338)2.46066439
168regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44238411
169regulation of histone H3-K9 methylation (GO:0051570)2.44202216
170respiratory electron transport chain (GO:0022904)2.43431498
171negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.43395117
172chromatin remodeling at centromere (GO:0031055)2.43076801
173detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42389964
174smoothened signaling pathway (GO:0007224)2.41961755
175postreplication repair (GO:0006301)2.41031677
176misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.40619672
177DNA synthesis involved in DNA repair (GO:0000731)2.40146578
178UTP biosynthetic process (GO:0006228)2.39919463
179detection of light stimulus involved in sensory perception (GO:0050962)2.38807346
180detection of light stimulus involved in visual perception (GO:0050908)2.38807346
181metallo-sulfur cluster assembly (GO:0031163)2.38302926
182iron-sulfur cluster assembly (GO:0016226)2.38302926
183C-terminal protein lipidation (GO:0006501)2.37826917
184peptidyl-histidine modification (GO:0018202)2.37786450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.98134572
2E2F7_22180533_ChIP-Seq_HELA_Human4.72042974
3ZNF274_21170338_ChIP-Seq_K562_Hela3.48624045
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.40838349
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.20845028
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02406198
7IGF1R_20145208_ChIP-Seq_DFB_Human3.01391016
8EZH2_22144423_ChIP-Seq_EOC_Human2.93021448
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.87014127
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83367316
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75744802
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.46748938
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37926936
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.37020326
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30486562
16VDR_22108803_ChIP-Seq_LS180_Human2.29329983
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26805271
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25402830
19IRF1_19129219_ChIP-ChIP_H3396_Human2.20590871
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.20190070
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15836411
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.15218233
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15209290
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.13141938
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.12757308
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12304643
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09778768
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09778259
29* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03755358
30VDR_23849224_ChIP-Seq_CD4+_Human2.01597275
31FOXP3_21729870_ChIP-Seq_TREG_Human1.89131701
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.87519235
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84925040
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83263300
35* GABP_19822575_ChIP-Seq_HepG2_Human1.81266080
36* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77384568
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75770410
38MYC_18940864_ChIP-ChIP_HL60_Human1.75481889
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72987124
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70094413
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69515290
42REST_21632747_ChIP-Seq_MESCs_Mouse1.69474336
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.69147542
44XRN2_22483619_ChIP-Seq_HELA_Human1.69023971
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68641582
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66894181
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64305140
48* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62174217
49MYC_22102868_ChIP-Seq_BL_Human1.60149584
50DCP1A_22483619_ChIP-Seq_HELA_Human1.59727262
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58645358
52CIITA_25753668_ChIP-Seq_RAJI_Human1.55564905
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.54538627
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.54382291
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54124136
56SCL_19346495_ChIP-Seq_HPC-7_Human1.52577678
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50841228
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50510155
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49852154
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49780347
61TP53_22573176_ChIP-Seq_HFKS_Human1.47695865
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47260861
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47180991
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44475288
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.44294879
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44048469
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43534366
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.42834152
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41963861
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40814446
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39677729
72ERA_21632823_ChIP-Seq_H3396_Human1.39068751
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38051193
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37396362
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36552458
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35738276
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35668740
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35587160
79VDR_21846776_ChIP-Seq_THP-1_Human1.34780863
80SPI1_23547873_ChIP-Seq_NB4_Human1.33756675
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33126932
82RNF2_27304074_Chip-Seq_NSC_Mouse1.31808254
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31125622
84GBX2_23144817_ChIP-Seq_PC3_Human1.30562611
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29864221
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27664227
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26289080
88* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25703997
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25486006
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23990474
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23769532
92* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23375277
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23293520
94TTF2_22483619_ChIP-Seq_HELA_Human1.22793008
95* YY1_22570637_ChIP-Seq_MALME-3M_Human1.22590309
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20593957
97MYB_26560356_Chip-Seq_TH2_Human1.20129160
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18464927
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.17350966
100* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16453281
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.15720325
102ER_23166858_ChIP-Seq_MCF-7_Human1.15080263
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14974057
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14955094
105NCOR_22424771_ChIP-Seq_293T_Human1.14728774
106EWS_26573619_Chip-Seq_HEK293_Human1.14225542
107E2F1_20622854_ChIP-Seq_HELA_Human1.13749492
108EED_16625203_ChIP-ChIP_MESCs_Mouse1.13589547
109KDM5A_27292631_Chip-Seq_BREAST_Human1.13394014
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.13063629
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.12772860
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12469694
113RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12082272
114MYC_19829295_ChIP-Seq_ESCs_Human1.11847715
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10125483
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.09973581
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.09876512
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09608036
119CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09203378
120* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09055941
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08739786
122* MYB_26560356_Chip-Seq_TH1_Human1.08573748
123CTCF_20526341_ChIP-Seq_ESCs_Human1.07442449
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06976693
125AR_20517297_ChIP-Seq_VCAP_Human1.06827899
126EZH2_27304074_Chip-Seq_ESCs_Mouse1.05792661
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05435830
128GATA3_21878914_ChIP-Seq_MCF-7_Human1.05091411
129E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03916206
130PHF8_20622854_ChIP-Seq_HELA_Human1.03503034
131FOXA1_25329375_ChIP-Seq_VCAP_Human1.03466626
132FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03466626
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03446832
134SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03244969
135STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02983398
136FOXP1_21924763_ChIP-Seq_HESCs_Human1.02341548
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02129075
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01636872
139* ELF1_20517297_ChIP-Seq_JURKAT_Human1.01448166
140STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01136496
141HOXB7_26014856_ChIP-Seq_BT474_Human1.00848365
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00675833
143CTCF_26484167_Chip-Seq_Bcells_Mouse1.00568455
144SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00456784
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00021624
146GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99706390
147UTX_26944678_Chip-Seq_JUKART_Human0.98922927
148CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98575591
149NANOG_20526341_ChIP-Seq_ESCs_Human0.98085019
150TAF15_26573619_Chip-Seq_HEK293_Human0.97708742
151GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96909116
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96712987
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96472642
154BCL6_27268052_Chip-Seq_Bcells_Human0.96264326
155TAF2_19829295_ChIP-Seq_ESCs_Human0.95763482
156MAF_26560356_Chip-Seq_TH1_Human0.95087051
157P53_21459846_ChIP-Seq_SAOS-2_Human0.94784118
158* GATA3_21867929_ChIP-Seq_CD8_Mouse0.93559087
159OCT4_20526341_ChIP-Seq_ESCs_Human0.93466514
160ELK1_19687146_ChIP-ChIP_HELA_Human0.93317847
161JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93301849
162TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92414939
163SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90817051
164CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90529158
165DROSHA_22980978_ChIP-Seq_HELA_Human0.88975931
166CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88224687
167FUS_26573619_Chip-Seq_HEK293_Human0.88112726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.90090877
2MP0003693_abnormal_embryo_hatching3.64133867
3MP0008877_abnormal_DNA_methylation3.18667333
4MP0001929_abnormal_gametogenesis3.13603375
5MP0003698_abnormal_male_reproductive2.94656202
6MP0008058_abnormal_DNA_repair2.78658736
7MP0010094_abnormal_chromosome_stability2.76152342
8MP0005083_abnormal_biliary_tract2.75746509
9MP0008057_abnormal_DNA_replication2.48190690
10MP0002102_abnormal_ear_morphology2.43191966
11MP0003111_abnormal_nucleus_morphology2.42804336
12MP0008875_abnormal_xenobiotic_pharmacok2.39602494
13MP0008007_abnormal_cellular_replicative2.34545001
14MP0002210_abnormal_sex_determination2.33688861
15MP0001529_abnormal_vocalization2.25023294
16MP0003077_abnormal_cell_cycle2.21299813
17MP0003880_abnormal_central_pattern2.17596579
18MP0009046_muscle_twitch2.15525792
19MP0004142_abnormal_muscle_tone2.08295209
20MP0003136_yellow_coat_color2.07560939
21MP0001145_abnormal_male_reproductive2.05382947
22MP0004133_heterotaxia2.04046771
23MP0005551_abnormal_eye_electrophysiolog2.01676126
24MP0001502_abnormal_circadian_rhythm1.99443756
25MP0001968_abnormal_touch/_nociception1.93709347
26MP0008789_abnormal_olfactory_epithelium1.93228396
27MP0002396_abnormal_hematopoietic_system1.87701104
28MP0003763_abnormal_thymus_physiology1.86868176
29MP0005397_hematopoietic_system_phenotyp1.86579050
30MP0001545_abnormal_hematopoietic_system1.86579050
31MP0009745_abnormal_behavioral_response1.82520241
32MP0004957_abnormal_blastocyst_morpholog1.81040469
33MP0001835_abnormal_antigen_presentation1.80601444
34MP0001905_abnormal_dopamine_level1.77934543
35MP0006292_abnormal_olfactory_placode1.77851005
36MP0003646_muscle_fatigue1.76702904
37MP0003787_abnormal_imprinting1.75962333
38MP0005075_abnormal_melanosome_morpholog1.75679952
39MP0003786_premature_aging1.75379329
40MP0005671_abnormal_response_to1.72176386
41MP0002693_abnormal_pancreas_physiology1.71173288
42MP0000653_abnormal_sex_gland1.70956278
43MP0004885_abnormal_endolymph1.69246524
44MP0000490_abnormal_crypts_of1.68778610
45MP0000685_abnormal_immune_system1.68331924
46MP0002272_abnormal_nervous_system1.67311246
47MP0005423_abnormal_somatic_nervous1.67063078
48MP0009333_abnormal_splenocyte_physiolog1.66392072
49MP0005174_abnormal_tail_pigmentation1.66363895
50MP0005394_taste/olfaction_phenotype1.62537114
51MP0005499_abnormal_olfactory_system1.62537114
52MP0002736_abnormal_nociception_after1.61986119
53MP0002877_abnormal_melanocyte_morpholog1.61098213
54MP0004742_abnormal_vestibular_system1.59940774
55MP0005645_abnormal_hypothalamus_physiol1.58508505
56MP0002161_abnormal_fertility/fecundity1.58448537
57MP0002653_abnormal_ependyma_morphology1.57067595
58MP0005171_absent_coat_pigmentation1.54787062
59MP0002557_abnormal_social/conspecific_i1.54203548
60MP0002572_abnormal_emotion/affect_behav1.52948739
61MP0003866_abnormal_defecation1.52214353
62MP0002398_abnormal_bone_marrow1.52149300
63MP0001984_abnormal_olfaction1.52110573
64MP0004808_abnormal_hematopoietic_stem1.51887494
65MP0000778_abnormal_nervous_system1.51213153
66MP0005253_abnormal_eye_physiology1.48529315
67MP0002064_seizures1.47962953
68MP0006276_abnormal_autonomic_nervous1.47537106
69MP0005220_abnormal_exocrine_pancreas1.46341729
70MP0001188_hyperpigmentation1.45274000
71MP0002822_catalepsy1.45023580
72MP0006072_abnormal_retinal_apoptosis1.43290447
73MP0008961_abnormal_basal_metabolism1.41462704
74MP0000015_abnormal_ear_pigmentation1.40046926
75MP0001944_abnormal_pancreas_morphology1.38973357
76MP0003183_abnormal_peptide_metabolism1.38956628
77MP0003635_abnormal_synaptic_transmissio1.38598850
78MP0004859_abnormal_synaptic_plasticity1.36694123
79MP0002928_abnormal_bile_duct1.35925813
80MP0003122_maternal_imprinting1.35464379
81MP0009785_altered_susceptibility_to1.35001102
82MP0000678_abnormal_parathyroid_gland1.33769582
83MP0008872_abnormal_physiological_respon1.32747721
84MP0005379_endocrine/exocrine_gland_phen1.29691151
85MP0002063_abnormal_learning/memory/cond1.29141899
86MP0001986_abnormal_taste_sensitivity1.28503004
87MP0000631_abnormal_neuroendocrine_gland1.27903310
88MP0000569_abnormal_digit_pigmentation1.26666496
89MP0002160_abnormal_reproductive_system1.26223712
90MP0001486_abnormal_startle_reflex1.26067332
91MP0002735_abnormal_chemical_nociception1.24318224
92MP0005646_abnormal_pituitary_gland1.23957008
93MP0000313_abnormal_cell_death1.21980453
94MP0002722_abnormal_immune_system1.21685038
95MP0000703_abnormal_thymus_morphology1.21662518
96MP0002067_abnormal_sensory_capabilities1.21648397
97MP0000689_abnormal_spleen_morphology1.20590050
98MP0009278_abnormal_bone_marrow1.19907257
99MP0002277_abnormal_respiratory_mucosa1.19059826
100MP0000372_irregular_coat_pigmentation1.19055883
101MP0000049_abnormal_middle_ear1.18950018
102MP0002429_abnormal_blood_cell1.18217935
103MP0008995_early_reproductive_senescence1.18178984
104MP0002132_abnormal_respiratory_system1.17085801
105MP0000716_abnormal_immune_system1.15591797
106MP0002405_respiratory_system_inflammati1.15316465
107MP0003121_genomic_imprinting1.14324218
108MP0002420_abnormal_adaptive_immunity1.14165224
109MP0005025_abnormal_response_to1.13637096
110MP0000026_abnormal_inner_ear1.13378368
111MP0004147_increased_porphyrin_level1.13054490
112MP0001819_abnormal_immune_cell1.12914322
113MP0002019_abnormal_tumor_incidence1.12348090
114MP0002095_abnormal_skin_pigmentation1.11828563
115MP0002723_abnormal_immune_serum1.11823608
116MP0001970_abnormal_pain_threshold1.09767717
117MP0004924_abnormal_behavior1.09617547
118MP0005386_behavior/neurological_phenoty1.09617547
119MP0000358_abnormal_cell_content/1.08751457
120MP0002734_abnormal_mechanical_nocicepti1.06989900
121MP0002638_abnormal_pupillary_reflex1.06984803
122MP0002837_dystrophic_cardiac_calcinosis1.06983367
123MP0001485_abnormal_pinna_reflex1.06743124
124MP0005000_abnormal_immune_tolerance1.06002391
125MP0001501_abnormal_sleep_pattern1.04679263
126MP0000955_abnormal_spinal_cord1.04444547
127MP0002184_abnormal_innervation1.03473501
128MP0006054_spinal_hemorrhage1.02929702
129MP0001324_abnormal_eye_pigmentation1.00340226
130MP0005464_abnormal_platelet_physiology0.99873639
131MP0002733_abnormal_thermal_nociception0.99753515
132MP0008932_abnormal_embryonic_tissue0.99443684
133MP0002882_abnormal_neuron_morphology0.99089733
134MP0002752_abnormal_somatic_nervous0.98981837
135MP0001800_abnormal_humoral_immune0.98910590
136MP0010307_abnormal_tumor_latency0.98302513
137MP0002452_abnormal_antigen_presenting0.97365396
138MP0002163_abnormal_gland_morphology0.97164170
139MP0003011_delayed_dark_adaptation0.96653400
140MP0003172_abnormal_lysosome_physiology0.95981182
141MP0003656_abnormal_erythrocyte_physiolo0.95936884
142MP0000566_synostosis0.94582499
143MP0005389_reproductive_system_phenotype0.93026062
144MP0005636_abnormal_mineral_homeostasis0.92325392
145MP0002751_abnormal_autonomic_nervous0.92264256
146MP0010155_abnormal_intestine_physiology0.91343625
147MP0001730_embryonic_growth_arrest0.90986526
148MP0002876_abnormal_thyroid_physiology0.90891385
149MP0005365_abnormal_bile_salt0.89124283
150MP0004264_abnormal_extraembryonic_tissu0.88770556
151MP0005167_abnormal_blood-brain_barrier0.88639797
152MP0003724_increased_susceptibility_to0.87718477
153MP0005195_abnormal_posterior_eye0.87639757
154MP0005387_immune_system_phenotype0.87539665
155MP0001790_abnormal_immune_system0.87539665
156MP0003943_abnormal_hepatobiliary_system0.86096153
157MP0003938_abnormal_ear_development0.85748936
158MP0002148_abnormal_hypersensitivity_rea0.85737877
159MP0006036_abnormal_mitochondrial_physio0.85548095
160MP0001963_abnormal_hearing_physiology0.85312669
161MP0003195_calcinosis0.85301741
162MP0003283_abnormal_digestive_organ0.84439426
163MP0002909_abnormal_adrenal_gland0.83101142
164MP0000465_gastrointestinal_hemorrhage0.83047662
165MP0009379_abnormal_foot_pigmentation0.82717192
166MP0006035_abnormal_mitochondrial_morpho0.82278658
167MP0000858_altered_metastatic_potential0.81822831
168MP0000350_abnormal_cell_proliferation0.81739728
169MP0004811_abnormal_neuron_physiology0.81516069
170MP0004043_abnormal_pH_regulation0.80870599
171MP0002229_neurodegeneration0.80072880
172MP0003436_decreased_susceptibility_to0.77869411
173MP0001765_abnormal_ion_homeostasis0.77707521
174MP0001873_stomach_inflammation0.77313654
175MP0002938_white_spotting0.74882664
176MP0002166_altered_tumor_susceptibility0.74485754
177MP0001845_abnormal_inflammatory_respons0.72732950
178MP0002080_prenatal_lethality0.71773782
179MP0001764_abnormal_homeostasis0.71589314
180MP0002234_abnormal_pharynx_morphology0.70547164
181MP0000013_abnormal_adipose_tissue0.68858236

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.55600236
2Absent/shortened dynein arms (HP:0200106)6.94258516
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.94258516
4Abnormal respiratory epithelium morphology (HP:0012253)5.43886959
5Abnormal respiratory motile cilium morphology (HP:0005938)5.43886959
6Nasal polyposis (HP:0100582)5.31331822
7Abnormal respiratory motile cilium physiology (HP:0012261)5.27816089
8Chronic bronchitis (HP:0004469)5.27101557
9Rhinitis (HP:0012384)4.85954090
10Abnormality of the nasal mucosa (HP:0000433)4.35228215
11Bronchitis (HP:0012387)4.30258605
12Abnormal ciliary motility (HP:0012262)4.01929531
13Bronchiectasis (HP:0002110)3.93728174
14Infertility (HP:0000789)3.66004867
15Recurrent bronchitis (HP:0002837)3.65696636
16Type I transferrin isoform profile (HP:0003642)3.45674900
17Abnormal number of erythroid precursors (HP:0012131)3.40765268
18Abnormal protein glycosylation (HP:0012346)3.31832711
19Abnormal glycosylation (HP:0012345)3.31832711
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.31832711
21Abnormal protein N-linked glycosylation (HP:0012347)3.31832711
22Increased hepatocellular lipid droplets (HP:0006565)3.28237771
23Abnormality of cells of the erythroid lineage (HP:0012130)3.23707489
24Abnormality of the anterior horn cell (HP:0006802)3.22911742
25Degeneration of anterior horn cells (HP:0002398)3.22911742
26Lipid accumulation in hepatocytes (HP:0006561)3.13778737
27Occipital encephalocele (HP:0002085)3.12103459
28Mitochondrial inheritance (HP:0001427)3.05351251
29Gait imbalance (HP:0002141)3.04014027
3011 pairs of ribs (HP:0000878)2.93784576
31Recurrent sinusitis (HP:0011108)2.92495802
32Congenital primary aphakia (HP:0007707)2.90522115
33Acute necrotizing encephalopathy (HP:0006965)2.87238951
34Nephronophthisis (HP:0000090)2.85265532
35Hepatocellular necrosis (HP:0001404)2.80689229
36Increased CSF lactate (HP:0002490)2.79343066
37Abnormal spermatogenesis (HP:0008669)2.76498000
38Reduced antithrombin III activity (HP:0001976)2.75569657
39Renal Fanconi syndrome (HP:0001994)2.70956571
40Nephrogenic diabetes insipidus (HP:0009806)2.69868826
41Recurrent otitis media (HP:0000403)2.65511006
42Abnormal mitochondria in muscle tissue (HP:0008316)2.63275000
43Sclerocornea (HP:0000647)2.62964188
44Aplastic anemia (HP:0001915)2.62242753
45Retinal dysplasia (HP:0007973)2.61828706
46Abnormality of the renal cortex (HP:0011035)2.61534738
47Lissencephaly (HP:0001339)2.52765700
48Anencephaly (HP:0002323)2.52275798
49Chronic otitis media (HP:0000389)2.49404264
50Hepatic necrosis (HP:0002605)2.48626958
51IgM deficiency (HP:0002850)2.47903036
52Acute encephalopathy (HP:0006846)2.47416670
53Chronic hepatic failure (HP:0100626)2.47277644
54Tubular atrophy (HP:0000092)2.44327695
55Congenital stationary night blindness (HP:0007642)2.43502711
56Increased intramyocellular lipid droplets (HP:0012240)2.42854457
57Cerebellar dysplasia (HP:0007033)2.42782335
58Thrombocytosis (HP:0001894)2.39064265
59Abnormality of T cell physiology (HP:0011840)2.38861052
60Chronic sinusitis (HP:0011109)2.37092544
61Pendular nystagmus (HP:0012043)2.36348087
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35950690
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.34812165
64Progressive microcephaly (HP:0000253)2.34454892
65Abnormality of midbrain morphology (HP:0002418)2.34289060
66Molar tooth sign on MRI (HP:0002419)2.34289060
67Bile duct proliferation (HP:0001408)2.25682242
68Abnormal biliary tract physiology (HP:0012439)2.25682242
69Progressive macrocephaly (HP:0004481)2.25062269
70Impulsivity (HP:0100710)2.23668644
71Male pseudohermaphroditism (HP:0000037)2.21671756
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16371962
73Absent speech (HP:0001344)2.14954521
74Abnormality of the renal medulla (HP:0100957)2.14121056
75Optic disc pallor (HP:0000543)2.12376898
76Increased muscle lipid content (HP:0009058)2.09989105
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.08906111
78Pancreatic fibrosis (HP:0100732)2.07321328
79Tubulointerstitial nephritis (HP:0001970)2.07304129
80Focal motor seizures (HP:0011153)2.06212053
81Reticulocytopenia (HP:0001896)2.05000220
82Preaxial hand polydactyly (HP:0001177)2.03442574
83Vaginal atresia (HP:0000148)2.02925445
84True hermaphroditism (HP:0010459)2.02491756
85Facial cleft (HP:0002006)2.01977756
86Severe visual impairment (HP:0001141)2.01238245
87Tubulointerstitial abnormality (HP:0001969)2.01220200
88Postaxial hand polydactyly (HP:0001162)2.00946922
89Genital tract atresia (HP:0001827)1.99263947
90Gonadotropin excess (HP:0000837)1.99178092
91Aganglionic megacolon (HP:0002251)1.98513140
92Increased serum lactate (HP:0002151)1.98401950
93Poor coordination (HP:0002370)1.97331607
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.96876148
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96818749
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96818749
97Poikiloderma (HP:0001029)1.96745468
98Microretrognathia (HP:0000308)1.95617970
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93609166
100Hyperinsulinemic hypoglycemia (HP:0000825)1.92736707
1013-Methylglutaconic aciduria (HP:0003535)1.91738877
102Abnormal rod and cone electroretinograms (HP:0008323)1.91227660
103Pancreatic cysts (HP:0001737)1.90591901
104Pachygyria (HP:0001302)1.89182654
105Polyuria (HP:0000103)1.88762071
106Elevated erythrocyte sedimentation rate (HP:0003565)1.88749189
107Rib fusion (HP:0000902)1.88488465
108Concave nail (HP:0001598)1.88462191
109Patellar aplasia (HP:0006443)1.88072884
110Attenuation of retinal blood vessels (HP:0007843)1.88072803
111Exertional dyspnea (HP:0002875)1.87881576
112Abnormality of the preputium (HP:0100587)1.87466657
113Selective tooth agenesis (HP:0001592)1.87462219
114Type II lissencephaly (HP:0007260)1.86946768
115Optic nerve coloboma (HP:0000588)1.86805596
116Myositis (HP:0100614)1.85023888
117Muscle fiber atrophy (HP:0100295)1.84848721
118Large eyes (HP:0001090)1.84441575
119Oculomotor apraxia (HP:0000657)1.83709478
120Retinitis pigmentosa (HP:0000510)1.83630178
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.83366464
122Hyperventilation (HP:0002883)1.81475949
123Bone marrow hypocellularity (HP:0005528)1.81356385
124Sloping forehead (HP:0000340)1.81258368
125Prominent metopic ridge (HP:0005487)1.81243797
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80772116
127Aplasia/Hypoplasia of the patella (HP:0006498)1.80662345
128Furrowed tongue (HP:0000221)1.80184988
129Cerebral edema (HP:0002181)1.78740923
130Lactic acidosis (HP:0003128)1.77879490
131Petechiae (HP:0000967)1.77240609
132Hypoplasia of the brainstem (HP:0002365)1.75930125
133Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75930125
134Abnormality of T cells (HP:0002843)1.75867632
135Azoospermia (HP:0000027)1.75535030
136Hyperglycinemia (HP:0002154)1.75432724
137Prominent nasal bridge (HP:0000426)1.75411997
138Meckel diverticulum (HP:0002245)1.75171377
139Narrow forehead (HP:0000341)1.74986405
140Abnormality of the labia minora (HP:0012880)1.74551826
141Severe muscular hypotonia (HP:0006829)1.74047169
142Asplenia (HP:0001746)1.73784656
143Hypoplasia of the pons (HP:0012110)1.73156078
144Abnormality of the ileum (HP:0001549)1.73095395
145Myelodysplasia (HP:0002863)1.72935304
146Decreased central vision (HP:0007663)1.71984203
147Late onset (HP:0003584)1.71935608
148Type 2 muscle fiber atrophy (HP:0003554)1.71107568
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.70643034
150Male infertility (HP:0003251)1.67327495
151Medial flaring of the eyebrow (HP:0010747)1.66961784
152Postaxial foot polydactyly (HP:0001830)1.65546400
153Cystic liver disease (HP:0006706)1.65524799
154Pancytopenia (HP:0001876)1.65208875
155Abnormal delayed hypersensitivity skin test (HP:0002963)1.64730004
156Abnormality of DNA repair (HP:0003254)1.63449836
157Hypoplasia of the thymus (HP:0000778)1.61876469
158Pallor (HP:0000980)1.61012783
159Entropion (HP:0000621)1.60767548
160Amyotrophic lateral sclerosis (HP:0007354)1.60221585
161Symptomatic seizures (HP:0011145)1.59149364
162Abnormality of chromosome stability (HP:0003220)1.57968351
163Large for gestational age (HP:0001520)1.54819469
164IgG deficiency (HP:0004315)1.54088272
165Congenital hepatic fibrosis (HP:0002612)1.53167639
166Abnormality of the pons (HP:0007361)1.52866154
167Hypoglycemic seizures (HP:0002173)1.52627739
168Albinism (HP:0001022)1.51008229
169Abnormal drinking behavior (HP:0030082)1.50972242
170Polydipsia (HP:0001959)1.50972242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.05501145
2PDK44.05501145
3TESK13.85987938
4PASK3.61163272
5STK163.40470667
6VRK22.93723544
7MAP4K22.61042524
8MAPK152.58756033
9DYRK32.57060793
10NEK22.53188907
11BUB12.51407930
12PDK22.34857899
13MAP3K42.33989272
14MARK12.23507654
15MAP2K72.23289830
16DYRK22.13270651
17MAP4K12.04701977
18FLT32.02677844
19CDC72.02241168
20MAPK132.01155799
21WEE12.01124266
22VRK11.98490107
23CASK1.92839440
24NUAK11.83676146
25DYRK1B1.71629241
26NME21.71255799
27PINK11.70490483
28EIF2AK31.69944264
29PRKD31.68932092
30PNCK1.66542994
31ERN11.66380078
32BMPR1B1.60679990
33GRK11.57552580
34FRK1.51536831
35TRIM281.50725592
36BCR1.50273553
37SIK21.45288572
38IRAK21.42855475
39MAP3K101.42154796
40EIF2AK11.38014512
41EEF2K1.37620193
42ICK1.37111783
43EPHA41.36234874
44BTK1.34664896
45CCNB11.33300958
46ZAP701.32720872
47CSNK1G31.32615055
48IRAK41.30909096
49TLK11.28222274
50ATR1.27254078
51PLK41.26536111
52KIT1.26290148
53BRSK21.24591982
54MAPKAPK51.23588486
55TBK11.21732985
56CSNK1G21.18671320
57TEC1.11148854
58HIPK21.09444135
59INSRR1.09240531
60PRKCG1.06202310
61TESK21.04462189
62CHEK21.03922940
63PKN11.02626949
64IRAK11.02514702
65EPHA31.02314173
66SRPK11.01877941
67PAK31.01260449
68CSNK1A1L0.99325543
69CSNK1G10.97930980
70JAK30.97480066
71TTK0.97294155
72MAP2K40.97133546
73CDK70.95148518
74OXSR10.94883025
75WNK40.94493749
76TSSK60.91450364
77TNIK0.90955429
78PAK60.90645732
79CSF1R0.90455061
80PLK10.87428441
81ACVR1B0.86320844
82TXK0.84079475
83TAOK30.83426031
84PIM20.82771412
85SCYL20.82479368
86KDR0.82202401
87NTRK20.81197324
88CHUK0.80282980
89MAP3K110.78760895
90ADRBK10.78607336
91CAMK1D0.78407337
92LIMK10.77581915
93STK390.77103017
94RPS6KA40.76973551
95IKBKE0.75818820
96AURKB0.74778806
97TAF10.70220536
98CAMKK10.69503548
99BRSK10.69259980
100CAMK10.68871652
101MAPKAPK30.66975358
102CDK40.66563557
103ZAK0.66349333
104CDK190.66145654
105BRAF0.64822883
106NME10.64504665
107CHEK10.64488299
108MARK30.63362377
109DAPK20.63216042
110BLK0.63181714
111ADRBK20.62870563
112AURKA0.62616335
113PHKG10.61958618
114PHKG20.61958618
115SYK0.60867669
116WNK30.60044447
117YES10.57411055
118PIM10.56504677
119PTK2B0.56402899
120ERBB30.56295130
121MUSK0.55369285
122MAP2K60.53937107
123NTRK30.53686208
124IRAK30.53549834
125TYK20.53010438
126LYN0.52895859
127IKBKB0.51655118
128BCKDK0.49469181
129PIK3CG0.48239106
130ITK0.47051784
131TRIB30.46302528
132STK40.46290093
133PLK20.45878879
134ATM0.45839653
135SIK30.45305005
136PRKCE0.44784549
137PAK40.43908630
138PRKACA0.43843011
139PLK30.43345268
140MAP3K70.43335085
141DYRK1A0.42284936
142RPS6KB20.42081027
143NLK0.40679216
144CLK10.39734487
145PRKCI0.39434753
146CSNK2A10.38748875
147PRKCZ0.38134501
148PRKAA10.37941130
149PAK10.37747350
150LCK0.37254439
151MAP3K80.36221324
152CAMK40.36209058
153RPS6KA50.35458395
154CAMK2A0.35361728
155CAMKK20.35131544
156MAP2K30.35077403
157CSNK1A10.34966962
158CAMK1G0.34864582
159BRD40.32496431
160MINK10.31415661
161PRKCQ0.31022446
162CDK50.29699722
163ABL20.29623333

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.09434617
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.48083680
3Oxidative phosphorylation_Homo sapiens_hsa001903.37655034
4Protein export_Homo sapiens_hsa030603.16171286
5Mismatch repair_Homo sapiens_hsa034303.13647885
6Base excision repair_Homo sapiens_hsa034102.79087993
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.77827550
8Parkinsons disease_Homo sapiens_hsa050122.69039663
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55180210
10Nicotine addiction_Homo sapiens_hsa050332.49114641
11Fanconi anemia pathway_Homo sapiens_hsa034602.44066018
12Homologous recombination_Homo sapiens_hsa034402.43578513
13Pyrimidine metabolism_Homo sapiens_hsa002402.40783944
14Phototransduction_Homo sapiens_hsa047442.39022852
15Basal transcription factors_Homo sapiens_hsa030222.33370942
16Ribosome_Homo sapiens_hsa030102.32169760
17Spliceosome_Homo sapiens_hsa030402.30068300
18Nucleotide excision repair_Homo sapiens_hsa034202.25398513
19Proteasome_Homo sapiens_hsa030502.21893950
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12802248
21Selenocompound metabolism_Homo sapiens_hsa004502.08436002
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98997792
23RNA polymerase_Homo sapiens_hsa030201.98963389
24Butanoate metabolism_Homo sapiens_hsa006501.89220053
25N-Glycan biosynthesis_Homo sapiens_hsa005101.85441545
26RNA transport_Homo sapiens_hsa030131.84112548
27Vitamin B6 metabolism_Homo sapiens_hsa007501.81457607
28Cell cycle_Homo sapiens_hsa041101.72184008
29Antigen processing and presentation_Homo sapiens_hsa046121.61400669
30Folate biosynthesis_Homo sapiens_hsa007901.60225628
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59594726
32Primary immunodeficiency_Homo sapiens_hsa053401.57584083
33Sulfur relay system_Homo sapiens_hsa041221.56605273
34Cardiac muscle contraction_Homo sapiens_hsa042601.54931948
35Alzheimers disease_Homo sapiens_hsa050101.52769862
36Other glycan degradation_Homo sapiens_hsa005111.50438328
37Purine metabolism_Homo sapiens_hsa002301.49927709
38RNA degradation_Homo sapiens_hsa030181.44008590
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43601668
40Pentose phosphate pathway_Homo sapiens_hsa000301.40222402
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39624376
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38924527
43Non-homologous end-joining_Homo sapiens_hsa034501.38100218
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37104064
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34772155
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34640143
47Systemic lupus erythematosus_Homo sapiens_hsa053221.32734690
48Collecting duct acid secretion_Homo sapiens_hsa049661.30023809
49Fatty acid elongation_Homo sapiens_hsa000621.26340329
50Synaptic vesicle cycle_Homo sapiens_hsa047211.22142636
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21753052
52Peroxisome_Homo sapiens_hsa041461.18793670
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18137637
54Linoleic acid metabolism_Homo sapiens_hsa005911.16956087
55p53 signaling pathway_Homo sapiens_hsa041151.16843705
56Nitrogen metabolism_Homo sapiens_hsa009101.16506032
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13684585
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12922340
59Taste transduction_Homo sapiens_hsa047421.12139553
60Chemical carcinogenesis_Homo sapiens_hsa052041.11635052
61Caffeine metabolism_Homo sapiens_hsa002321.11178687
62Tryptophan metabolism_Homo sapiens_hsa003801.10916455
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10792276
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.09173952
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.06166003
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05606598
67mRNA surveillance pathway_Homo sapiens_hsa030151.02304746
68beta-Alanine metabolism_Homo sapiens_hsa004101.01785124
69Measles_Homo sapiens_hsa051621.01253206
70Herpes simplex infection_Homo sapiens_hsa051681.00975469
71Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00597820
72Legionellosis_Homo sapiens_hsa051340.97507819
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96882540
74Propanoate metabolism_Homo sapiens_hsa006400.95630721
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93707718
76Steroid biosynthesis_Homo sapiens_hsa001000.93387989
77Tyrosine metabolism_Homo sapiens_hsa003500.92064893
78One carbon pool by folate_Homo sapiens_hsa006700.91550571
79Epstein-Barr virus infection_Homo sapiens_hsa051690.88552557
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88198409
81Viral carcinogenesis_Homo sapiens_hsa052030.87811654
82GABAergic synapse_Homo sapiens_hsa047270.87182287
83Olfactory transduction_Homo sapiens_hsa047400.86127372
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85980471
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85665785
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85293535
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82222157
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82189560
89Morphine addiction_Homo sapiens_hsa050320.80203404
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79879317
91Fructose and mannose metabolism_Homo sapiens_hsa000510.78348572
92Cocaine addiction_Homo sapiens_hsa050300.77072981
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.74884158
94Alcoholism_Homo sapiens_hsa050340.71997754
95Hematopoietic cell lineage_Homo sapiens_hsa046400.70822228
96Phenylalanine metabolism_Homo sapiens_hsa003600.69248709
97Galactose metabolism_Homo sapiens_hsa000520.67986496
98Hedgehog signaling pathway_Homo sapiens_hsa043400.66784521
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.64875279
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64582163
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64578302
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64410969
103Arachidonic acid metabolism_Homo sapiens_hsa005900.63128562
104B cell receptor signaling pathway_Homo sapiens_hsa046620.60333062
105Glutamatergic synapse_Homo sapiens_hsa047240.59475362
106Acute myeloid leukemia_Homo sapiens_hsa052210.59331139
107Sphingolipid metabolism_Homo sapiens_hsa006000.58970514
108Huntingtons disease_Homo sapiens_hsa050160.58676403
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57653074
110HTLV-I infection_Homo sapiens_hsa051660.55946284
111Arginine and proline metabolism_Homo sapiens_hsa003300.55286786
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.55276556
113ABC transporters_Homo sapiens_hsa020100.53777732
114Regulation of autophagy_Homo sapiens_hsa041400.53020022
115Circadian entrainment_Homo sapiens_hsa047130.52609820
116Retinol metabolism_Homo sapiens_hsa008300.51324624
117Sulfur metabolism_Homo sapiens_hsa009200.50141763
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47236314
119Ovarian steroidogenesis_Homo sapiens_hsa049130.46985321
120Glucagon signaling pathway_Homo sapiens_hsa049220.46877152
121Lysosome_Homo sapiens_hsa041420.46646821
122Influenza A_Homo sapiens_hsa051640.45549047
123Histidine metabolism_Homo sapiens_hsa003400.45237832
124Basal cell carcinoma_Homo sapiens_hsa052170.44602928
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44305493
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.44248523
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.43982883
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43325634
129Oocyte meiosis_Homo sapiens_hsa041140.42058335
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41783571
131Insulin secretion_Homo sapiens_hsa049110.41222947
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.41012179
133Pyruvate metabolism_Homo sapiens_hsa006200.40950386
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40843271
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40663434
136Axon guidance_Homo sapiens_hsa043600.40209254
137Vibrio cholerae infection_Homo sapiens_hsa051100.38887092
138Fatty acid degradation_Homo sapiens_hsa000710.37544797
139Serotonergic synapse_Homo sapiens_hsa047260.37197857
140Glycerolipid metabolism_Homo sapiens_hsa005610.37083472
141T cell receptor signaling pathway_Homo sapiens_hsa046600.36771962
142Apoptosis_Homo sapiens_hsa042100.36694844
143Shigellosis_Homo sapiens_hsa051310.36592430
144Fat digestion and absorption_Homo sapiens_hsa049750.36336700
145Renin-angiotensin system_Homo sapiens_hsa046140.36185370
146Metabolic pathways_Homo sapiens_hsa011000.36148633
147Type I diabetes mellitus_Homo sapiens_hsa049400.35336332
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.35303160
149Hepatitis B_Homo sapiens_hsa051610.31942073
150Glutathione metabolism_Homo sapiens_hsa004800.28463551
151Thyroid cancer_Homo sapiens_hsa052160.26979614
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24029810
153Notch signaling pathway_Homo sapiens_hsa043300.22587467
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20924612
155Ether lipid metabolism_Homo sapiens_hsa005650.19571417
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15690544
157Allograft rejection_Homo sapiens_hsa053300.14038424
158Toll-like receptor signaling pathway_Homo sapiens_hsa046200.13673380

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