ANKRD55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.53538261
2neutrophil activation involved in immune response (GO:0002283)6.09906946
3thrombin receptor signaling pathway (GO:0070493)5.79205361
4leukocyte migration involved in inflammatory response (GO:0002523)5.41219086
5presynaptic membrane organization (GO:0097090)5.23755206
6presynaptic membrane assembly (GO:0097105)4.97293312
7facial nerve structural organization (GO:0021612)4.67933967
8regulation of platelet aggregation (GO:0090330)4.57175794
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54689396
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.44077229
11neutrophil activation (GO:0042119)4.29646907
12postsynaptic membrane organization (GO:0001941)4.24363108
13regulation of MHC class II biosynthetic process (GO:0045346)4.23613757
14regulation of platelet activation (GO:0010543)4.23413843
15positive regulation of granulocyte differentiation (GO:0030854)4.10619882
16low-density lipoprotein particle remodeling (GO:0034374)4.10037803
17purinergic nucleotide receptor signaling pathway (GO:0035590)3.96014788
18neuronal action potential propagation (GO:0019227)3.93251433
19G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.92246413
20neuromuscular process controlling posture (GO:0050884)3.84984895
21high-density lipoprotein particle remodeling (GO:0034375)3.81662579
22blood coagulation, intrinsic pathway (GO:0007597)3.77616632
23phospholipid homeostasis (GO:0055091)3.76828407
24vocalization behavior (GO:0071625)3.74140715
25respiratory chain complex IV assembly (GO:0008535)3.73827083
26negative regulation of thymocyte apoptotic process (GO:0070244)3.73672501
27negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.72693320
28negative regulation of T-helper cell differentiation (GO:0045623)3.72693320
29positive regulation of mast cell activation (GO:0033005)3.71021745
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.70198944
31succinate metabolic process (GO:0006105)3.67851185
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.65858217
33granulocyte activation (GO:0036230)3.56219173
34cranial nerve structural organization (GO:0021604)3.55615075
35leukocyte degranulation (GO:0043299)3.55553257
36regulation of memory T cell differentiation (GO:0043380)3.53229198
37opioid receptor signaling pathway (GO:0038003)3.51064241
38peptidyl-threonine dephosphorylation (GO:0035970)3.50717737
39negative regulation of platelet activation (GO:0010544)3.50629917
40autophagic vacuole fusion (GO:0000046)3.47986362
41cytochrome complex assembly (GO:0017004)3.47602430
42neuron cell-cell adhesion (GO:0007158)3.45736246
43reverse cholesterol transport (GO:0043691)3.42414230
44startle response (GO:0001964)3.41904372
45lymphoid progenitor cell differentiation (GO:0002320)3.35581999
46mannosylation (GO:0097502)3.32760554
47neurofilament cytoskeleton organization (GO:0060052)3.32329132
48protein complex biogenesis (GO:0070271)3.32263782
49regulation of Golgi to plasma membrane protein transport (GO:0042996)3.28046430
50negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.27973848
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26421762
52neurotransmitter secretion (GO:0007269)3.26086347
53N-acetylneuraminate metabolic process (GO:0006054)3.25901736
54protein localization to cilium (GO:0061512)3.25184027
55mast cell activation (GO:0045576)3.24435714
56negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.22457361
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19188724
58organelle membrane fusion (GO:0090174)3.19031523
59cellular extravasation (GO:0045123)3.19024162
60positive regulation of synapse assembly (GO:0051965)3.18562211
61regulation of regulatory T cell differentiation (GO:0045589)3.18083370
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.18082744
63platelet aggregation (GO:0070527)3.18038896
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17821679
65adenosine receptor signaling pathway (GO:0001973)3.16448516
66mast cell degranulation (GO:0043303)3.15219697
67mast cell activation involved in immune response (GO:0002279)3.15219697
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15053690
69regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14195355
70positive regulation of endothelial cell differentiation (GO:0045603)3.13939893
71gamma-aminobutyric acid transport (GO:0015812)3.11854032
72activated T cell proliferation (GO:0050798)3.11539139
73negative regulation of calcium ion transport into cytosol (GO:0010523)3.10651566
74response to histamine (GO:0034776)3.09172295
75negative regulation of norepinephrine secretion (GO:0010700)3.08608920
76behavioral response to nicotine (GO:0035095)3.07604581
77positive regulation of cAMP-mediated signaling (GO:0043950)3.07130793
78angiogenesis involved in wound healing (GO:0060055)3.05531174
79positive regulation of amino acid transport (GO:0051957)3.03701612
80negative regulation of response to food (GO:0032096)3.02780303
81negative regulation of appetite (GO:0032099)3.02780303
82purinergic receptor signaling pathway (GO:0035587)2.97973397
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97795491
84protein localization to synapse (GO:0035418)2.97165148
85fusion of sperm to egg plasma membrane (GO:0007342)2.96783151
86negative regulation of T cell apoptotic process (GO:0070233)2.96297877
87neurotransmitter transport (GO:0006836)2.94252350
88termination of G-protein coupled receptor signaling pathway (GO:0038032)2.93884090
89lipoxygenase pathway (GO:0019372)2.93485855
90regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92643078
91negative regulation of erythrocyte differentiation (GO:0045647)2.92199633
92regulation of mast cell activation (GO:0033003)2.91589960
93oxaloacetate metabolic process (GO:0006107)2.89957545
94synaptic transmission, glutamatergic (GO:0035249)2.89438466
95regulation of lipoprotein metabolic process (GO:0050746)2.87740401
96neuron-neuron synaptic transmission (GO:0007270)2.86861075
97tolerance induction (GO:0002507)2.86790825
98negative regulation of homotypic cell-cell adhesion (GO:0034111)2.86693824
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86174841
100regulation of integrin-mediated signaling pathway (GO:2001044)2.83967012
101microglial cell activation (GO:0001774)2.82755910
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.82567677
103NADH dehydrogenase complex assembly (GO:0010257)2.82567677
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82567677
105dopamine transport (GO:0015872)2.82042510
106mitochondrial respiratory chain complex assembly (GO:0033108)2.81534847
107positive regulation of gamma-delta T cell activation (GO:0046645)2.80798963
108negative regulation of type 2 immune response (GO:0002829)2.79687966
109termination of signal transduction (GO:0023021)2.79069818
110myeloid cell activation involved in immune response (GO:0002275)2.78787449
111regulation of female receptivity (GO:0045924)2.78235055
112regulation of glutamate receptor signaling pathway (GO:1900449)2.77089615
113positive regulation of macrophage differentiation (GO:0045651)2.76327562
114short-term memory (GO:0007614)2.76032032
115positive regulation of DNA recombination (GO:0045911)2.75977286
116catecholamine transport (GO:0051937)2.74830555
117aerobic respiration (GO:0009060)2.74436932
118positive regulation of mitochondrial fission (GO:0090141)2.72467716
119regulation of neurotransmitter levels (GO:0001505)2.72019129
120regulation of penile erection (GO:0060405)2.71841005
121negative regulation of cell killing (GO:0031342)2.71057785
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71057785
123regulation of B cell receptor signaling pathway (GO:0050855)2.70949820
124synaptic vesicle exocytosis (GO:0016079)2.70755239
125megakaryocyte development (GO:0035855)2.70274554
126cranial nerve morphogenesis (GO:0021602)2.68881705
127pyrimidine nucleoside catabolic process (GO:0046135)2.67237567
128positive regulation of B cell mediated immunity (GO:0002714)2.67092608
129positive regulation of immunoglobulin mediated immune response (GO:0002891)2.67092608
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66912681
131neurotransmitter-gated ion channel clustering (GO:0072578)2.66561732
132positive regulation of cellular amine metabolic process (GO:0033240)2.66136079
133negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.66044009
134positive regulation of isotype switching (GO:0045830)2.64582949
135regulation of homotypic cell-cell adhesion (GO:0034110)2.64425834
136negative regulation of heart rate (GO:0010459)2.63870843
137acrosome reaction (GO:0007340)2.61519952
138regulation of thymocyte apoptotic process (GO:0070243)2.61518563
139proteasome assembly (GO:0043248)2.60729378
140amine catabolic process (GO:0009310)2.60596691
141cellular biogenic amine catabolic process (GO:0042402)2.60596691
142neurotransmitter biosynthetic process (GO:0042136)2.60369785
143righting reflex (GO:0060013)2.59639051
144regulation of macrophage derived foam cell differentiation (GO:0010743)2.58326963
145glutamate receptor signaling pathway (GO:0007215)2.57175171
146positive regulation of alpha-beta T cell proliferation (GO:0046641)2.55324921
147cilium or flagellum-dependent cell motility (GO:0001539)2.54689620
148mitochondrial fission (GO:0000266)2.54369341
149monoamine transport (GO:0015844)2.54195578
150platelet formation (GO:0030220)2.54136878
151hepatocyte apoptotic process (GO:0097284)2.54033066
152platelet dense granule organization (GO:0060155)2.53337720
153regulation of cholesterol esterification (GO:0010872)2.52382957
154regulation of synaptic vesicle exocytosis (GO:2000300)2.52296426
155superoxide anion generation (GO:0042554)2.52005775
156regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.50764078
157regulation of protein kinase A signaling (GO:0010738)2.50718047
158DNA deamination (GO:0045006)2.49914438
159neurotransmitter uptake (GO:0001504)2.49723492
160cellular biogenic amine biosynthetic process (GO:0042401)2.49226705
161regulation of synapse structural plasticity (GO:0051823)2.49224467
162homotypic cell-cell adhesion (GO:0034109)2.49083456
163positive regulation of membrane potential (GO:0045838)2.48998062
164respiratory electron transport chain (GO:0022904)2.48457423
165positive regulation of Rho protein signal transduction (GO:0035025)2.48317885
166negative regulation of B cell mediated immunity (GO:0002713)2.47674392
167negative regulation of immunoglobulin mediated immune response (GO:0002890)2.47674392
168lysosome localization (GO:0032418)2.47060736
169electron transport chain (GO:0022900)2.47051386
170ether lipid metabolic process (GO:0046485)2.46959401
171G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.46597466
172synaptic vesicle maturation (GO:0016188)2.46307549
173polyamine biosynthetic process (GO:0006596)2.45967826
174regulation of alpha-beta T cell proliferation (GO:0046640)2.45724704
175regulation of synapse assembly (GO:0051963)2.44582819
176inositol phosphate catabolic process (GO:0071545)2.43299325
177regulation of synaptic transmission, GABAergic (GO:0032228)2.43210288
178chaperone-mediated protein transport (GO:0072321)2.42965968
179positive regulation of action potential (GO:0045760)2.42054916
180fatty acid elongation (GO:0030497)2.41802140
181cytidine catabolic process (GO:0006216)2.41286292
182mature B cell differentiation involved in immune response (GO:0002313)2.39966132
183GDP-mannose metabolic process (GO:0019673)2.39768871
184positive regulation of amine transport (GO:0051954)2.37078684
185serotonin receptor signaling pathway (GO:0007210)2.37047704
186cofactor catabolic process (GO:0051187)2.34682650
187sympathetic nervous system development (GO:0048485)2.34620706
188CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.34286905
189regulation of excitatory postsynaptic membrane potential (GO:0060079)2.33655802
190mature B cell differentiation (GO:0002335)2.32011711
191negative regulation of alpha-beta T cell differentiation (GO:0046639)2.30385505
192mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.29334378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.38424904
2GBX2_23144817_ChIP-Seq_PC3_Human3.82350215
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29530436
4TAF15_26573619_Chip-Seq_HEK293_Human2.72524456
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72220366
6* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.70946554
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.67050518
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.60218559
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56300767
10VDR_22108803_ChIP-Seq_LS180_Human2.49975203
11IGF1R_20145208_ChIP-Seq_DFB_Human2.47358044
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40648750
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24707510
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.16684403
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09506797
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08655554
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04279104
18REST_21632747_ChIP-Seq_MESCs_Mouse2.03939450
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02267332
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99215769
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98860382
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.96390142
23* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.96155898
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93319082
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93319082
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91149568
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86163435
28RUNX_20019798_ChIP-Seq_JUKART_Human1.84314305
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82464946
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80300211
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.75413849
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73596150
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72856513
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72305815
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71496638
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.66906276
37BCAT_22108803_ChIP-Seq_LS180_Human1.63387331
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.63172216
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60162867
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59275696
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.57053173
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56529916
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54961347
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48174082
45* GATA1_19941826_ChIP-Seq_K562_Human1.48043893
46* SPI1_23127762_ChIP-Seq_K562_Human1.47765874
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46772058
48RNF2_27304074_Chip-Seq_NSC_Mouse1.46649796
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.46245069
50GATA3_26560356_Chip-Seq_TH2_Human1.45147364
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.44012771
52* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43768548
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42868381
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.42498244
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42072371
56* GATA2_19941826_ChIP-Seq_K562_Human1.41046042
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40270060
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.39867822
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.39688260
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39599318
61EWS_26573619_Chip-Seq_HEK293_Human1.38889520
62IRF1_19129219_ChIP-ChIP_H3396_Human1.38552193
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37738659
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37684146
65P300_19829295_ChIP-Seq_ESCs_Human1.36920134
66ZNF274_21170338_ChIP-Seq_K562_Hela1.36617923
67* SMAD4_21799915_ChIP-Seq_A2780_Human1.34902752
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34619651
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34525983
70* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34119290
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33170398
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.29216029
73SOX2_19829295_ChIP-Seq_ESCs_Human1.26024571
74NANOG_19829295_ChIP-Seq_ESCs_Human1.26024571
75SALL4_22934838_ChIP-ChIP_CD34+_Human1.25801291
76GATA3_27048872_Chip-Seq_THYMUS_Human1.25566121
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.24885608
78* MYB_26560356_Chip-Seq_TH2_Human1.24757978
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23016645
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22171744
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21395688
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.21320042
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.21281533
84ER_23166858_ChIP-Seq_MCF-7_Human1.20982334
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20951959
86TP53_22573176_ChIP-Seq_HFKS_Human1.20658262
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19592315
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18158797
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15900894
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.15900894
91AR_25329375_ChIP-Seq_VCAP_Human1.14966098
92KDM2B_26808549_Chip-Seq_REH_Human1.14487056
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12734051
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12702966
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.12335142
96* STAT3_23295773_ChIP-Seq_U87_Human1.11791403
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11552679
98ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10214043
99* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.09879052
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09848774
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09308466
102* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08835612
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08675268
104SMRT_27268052_Chip-Seq_Bcells_Human1.08197072
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07559537
106SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06764205
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05925299
108HTT_18923047_ChIP-ChIP_STHdh_Human1.05196861
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.05190935
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04621929
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03660797
112SPI1_23547873_ChIP-Seq_NB4_Human1.03237732
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03042200
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02962553
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.02838247
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02212801
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.01928498
118* TCF4_23295773_ChIP-Seq_U87_Human1.01768456
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00203314
120EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99851871
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99540424
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99399434
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98513946
124P53_22387025_ChIP-Seq_ESCs_Mouse0.98411609
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97944685
126SCL_19346495_ChIP-Seq_HPC-7_Human0.97376171
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96515359
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96369065
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.95673658
130* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95273869
131* SMAD4_21741376_ChIP-Seq_EPCs_Human0.95133036
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94990469
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94639906
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94474863
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93813033
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92825517
137* RUNX2_22187159_ChIP-Seq_PCA_Human0.92776324
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90404428
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.90212345
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.90183898
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.89692849
142P300_18555785_Chip-Seq_ESCs_Mouse0.88588166
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88408305
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88349326
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88111251
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87729662
147CBP_20019798_ChIP-Seq_JUKART_Human0.87729662
148JUN_21703547_ChIP-Seq_K562_Human0.86217637
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.84989029
150RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84653001
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.81980548
152ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81572273
153EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81486090
154NMYC_18555785_Chip-Seq_ESCs_Mouse0.81080482
155AR_21572438_ChIP-Seq_LNCaP_Human0.80796613
156PU1_27457419_Chip-Seq_LIVER_Mouse0.80358002
157RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79691651
158SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79309205
159MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79214380
160CTCF_18555785_Chip-Seq_ESCs_Mouse0.77729680
161* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76229468
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75930705
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.75840318
164OCT4_18555785_Chip-Seq_ESCs_Mouse0.75751357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.70289548
2MP0008004_abnormal_stomach_pH3.78009544
3MP0003880_abnormal_central_pattern3.36652249
4MP0006276_abnormal_autonomic_nervous3.28936676
5MP0002139_abnormal_hepatobiliary_system3.04264855
6MP0009379_abnormal_foot_pigmentation3.04066490
7MP0009046_muscle_twitch2.83519174
8MP0001188_hyperpigmentation2.64044399
9MP0001986_abnormal_taste_sensitivity2.59663596
10MP0003879_abnormal_hair_cell2.51449863
11MP0001968_abnormal_touch/_nociception2.48073272
12MP0009745_abnormal_behavioral_response2.45664687
13MP0003646_muscle_fatigue2.42538420
14MP0003635_abnormal_synaptic_transmissio2.42228342
15MP0002735_abnormal_chemical_nociception2.41713411
16MP0002064_seizures2.18803359
17MP0002876_abnormal_thyroid_physiology2.18044200
18MP0002272_abnormal_nervous_system2.15653964
19MP0005084_abnormal_gallbladder_morpholo2.14110623
20MP0003303_peritoneal_inflammation2.14109426
21MP0004859_abnormal_synaptic_plasticity2.13938104
22MP0000372_irregular_coat_pigmentation2.08570300
23MP0004142_abnormal_muscle_tone2.02330386
24MP0000015_abnormal_ear_pigmentation1.97990986
25MP0002736_abnormal_nociception_after1.92524311
26MP0003868_abnormal_feces_composition1.91683408
27MP0005083_abnormal_biliary_tract1.84882309
28MP0001501_abnormal_sleep_pattern1.81615948
29MP0003122_maternal_imprinting1.79902016
30MP0002067_abnormal_sensory_capabilities1.77687440
31MP0002572_abnormal_emotion/affect_behav1.75920879
32MP0005409_darkened_coat_color1.74699927
33MP0000569_abnormal_digit_pigmentation1.72127861
34MP0004381_abnormal_hair_follicle1.71495019
35MP0005174_abnormal_tail_pigmentation1.65425146
36MP0005000_abnormal_immune_tolerance1.63330967
37MP0002734_abnormal_mechanical_nocicepti1.58727282
38MP0010386_abnormal_urinary_bladder1.54581633
39MP0000230_abnormal_systemic_arterial1.54140308
40MP0001970_abnormal_pain_threshold1.53792428
41MP0005167_abnormal_blood-brain_barrier1.52747765
42MP0003763_abnormal_thymus_physiology1.51144542
43MP0002733_abnormal_thermal_nociception1.50581671
44MP0002723_abnormal_immune_serum1.50564545
45MP0010329_abnormal_lipoprotein_level1.50062983
46MP0002909_abnormal_adrenal_gland1.49473324
47MP0002063_abnormal_learning/memory/cond1.49143566
48MP0002822_catalepsy1.48519024
49MP0003724_increased_susceptibility_to1.46481861
50MP0002398_abnormal_bone_marrow1.46161032
51MP0005645_abnormal_hypothalamus_physiol1.44593513
52MP0004270_analgesia1.44197813
53MP0002184_abnormal_innervation1.44144130
54MP0001835_abnormal_antigen_presentation1.43453005
55MP0001486_abnormal_startle_reflex1.41905142
56MP0002095_abnormal_skin_pigmentation1.40830099
57MP0002557_abnormal_social/conspecific_i1.40635791
58MP0008569_lethality_at_weaning1.40570384
59MP0002420_abnormal_adaptive_immunity1.39510535
60MP0003787_abnormal_imprinting1.38954658
61MP0002132_abnormal_respiratory_system1.38917035
62MP0000681_abnormal_thyroid_gland1.38869965
63MP0003191_abnormal_cellular_cholesterol1.37421352
64MP0008877_abnormal_DNA_methylation1.37386470
65MP0001819_abnormal_immune_cell1.36402517
66MP0003436_decreased_susceptibility_to1.35024246
67MP0002452_abnormal_antigen_presenting1.33172548
68MP0002638_abnormal_pupillary_reflex1.29847684
69MP0000689_abnormal_spleen_morphology1.29494315
70MP0000465_gastrointestinal_hemorrhage1.29051580
71MP0002653_abnormal_ependyma_morphology1.28000728
72MP0003828_pulmonary_edema1.26160363
73MP0004510_myositis1.25827602
74MP0005646_abnormal_pituitary_gland1.24755722
75MP0005671_abnormal_response_to1.24432238
76MP0002138_abnormal_hepatobiliary_system1.22378791
77MP0002419_abnormal_innate_immunity1.22295927
78MP0005410_abnormal_fertilization1.22071971
79MP0005423_abnormal_somatic_nervous1.20430401
80MP0002102_abnormal_ear_morphology1.20325279
81MP0010155_abnormal_intestine_physiology1.19481231
82MP0001851_eye_inflammation1.19242568
83MP0009333_abnormal_splenocyte_physiolog1.18070287
84MP0008775_abnormal_heart_ventricle1.17825686
85MP0001905_abnormal_dopamine_level1.17275989
86MP0005075_abnormal_melanosome_morpholog1.15507796
87MP0003638_abnormal_response/metabolism_1.15167017
88MP0001440_abnormal_grooming_behavior1.15093843
89MP0000716_abnormal_immune_system1.14981600
90MP0009764_decreased_sensitivity_to1.13620400
91MP0002277_abnormal_respiratory_mucosa1.13619313
92MP0003195_calcinosis1.12260523
93MP0004147_increased_porphyrin_level1.12215392
94MP0004484_altered_response_of1.11655378
95MP0009785_altered_susceptibility_to1.11051630
96MP0002722_abnormal_immune_system1.10970540
97MP0001879_abnormal_lymphatic_vessel1.07858181
98MP0002429_abnormal_blood_cell1.06329180
99MP0008874_decreased_physiological_sensi1.05517271
100MP0000343_altered_response_to1.04824241
101MP0008875_abnormal_xenobiotic_pharmacok1.04736567
102MP0000703_abnormal_thymus_morphology1.01812452
103MP0001529_abnormal_vocalization1.01363307
104MP0005551_abnormal_eye_electrophysiolog1.00898204
105MP0005386_behavior/neurological_phenoty1.00337794
106MP0004924_abnormal_behavior1.00337794
107MP0001845_abnormal_inflammatory_respons0.99722489
108MP0002405_respiratory_system_inflammati0.99013843
109MP0001348_abnormal_lacrimal_gland0.96451219
110MP0001545_abnormal_hematopoietic_system0.96395493
111MP0005365_abnormal_bile_salt0.96177442
112MP0000604_amyloidosis0.94912845
113MP0003011_delayed_dark_adaptation0.94085272
114MP0001533_abnormal_skeleton_physiology0.93286154
115MP0000685_abnormal_immune_system0.93152335
116MP0005310_abnormal_salivary_gland0.92220866
117MP0006036_abnormal_mitochondrial_physio0.91889231
118MP0006054_spinal_hemorrhage0.90813156
119MP0000751_myopathy0.89251943
120MP0003329_amyloid_beta_deposits0.89244716
121MP0004215_abnormal_myocardial_fiber0.88758721
122MP0003656_abnormal_erythrocyte_physiolo0.88258477
123MP0001873_stomach_inflammation0.87495898
124MP0006035_abnormal_mitochondrial_morpho0.87449672
125MP0009765_abnormal_xenobiotic_induced0.86868747
126MP0004130_abnormal_muscle_cell0.86202346
127MP0005085_abnormal_gallbladder_physiolo0.85933396
128MP0001663_abnormal_digestive_system0.85033321
129MP0009763_increased_sensitivity_to0.84769496
130MP0005360_urolithiasis0.84767614
131MP0009697_abnormal_copulation0.83890426
132MP0004811_abnormal_neuron_physiology0.82141147
133MP0008260_abnormal_autophagy0.80233014
134MP0009642_abnormal_blood_homeostasis0.78788797
135MP0003890_abnormal_embryonic-extraembry0.78729971
136MP0003806_abnormal_nucleotide_metabolis0.78163817
137MP0002396_abnormal_hematopoietic_system0.77173711
138MP0002066_abnormal_motor_capabilities/c0.77091139
139MP0005535_abnormal_body_temperature0.76716089
140MP0006292_abnormal_olfactory_placode0.75158953
141MP0005025_abnormal_response_to0.74648668
142MP0000249_abnormal_blood_vessel0.74204185
143MP0002177_abnormal_outer_ear0.73315776
144MP0004883_abnormal_blood_vessel0.73075049
145MP0002751_abnormal_autonomic_nervous0.72401061
146MP0008872_abnormal_physiological_respon0.72183187
147MP0003136_yellow_coat_color0.71308983
148MP0002229_neurodegeneration0.71063249
149MP0005595_abnormal_vascular_smooth0.70541327
150MP0002118_abnormal_lipid_homeostasis0.69787718
151MP0001963_abnormal_hearing_physiology0.68993025
152MP0001800_abnormal_humoral_immune0.68981706
153MP0004085_abnormal_heartbeat0.68635770
154MP0003866_abnormal_defecation0.68164408
155MP0002148_abnormal_hypersensitivity_rea0.67860153
156MP0005647_abnormal_sex_gland0.67805246
157MP0001790_abnormal_immune_system0.66964263
158MP0005387_immune_system_phenotype0.66964263
159MP0001984_abnormal_olfaction0.66114147
160MP0005397_hematopoietic_system_phenotyp0.65166444

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)7.10627549
2Increased mean platelet volume (HP:0011877)6.90139666
3Petechiae (HP:0000967)6.79001247
4Abnormal platelet volume (HP:0011876)6.78482509
5Epistaxis (HP:0000421)5.85944956
6Focal motor seizures (HP:0011153)5.67109508
7Purpura (HP:0000979)5.63902798
8Gingival bleeding (HP:0000225)5.37271205
9Hypothermia (HP:0002045)5.18258891
10Hyperlipoproteinemia (HP:0010980)4.74887835
11Reduced antithrombin III activity (HP:0001976)4.49018911
12Stomatitis (HP:0010280)4.19871753
13Type I transferrin isoform profile (HP:0003642)4.18991711
14Febrile seizures (HP:0002373)4.01482399
15Spontaneous hematomas (HP:0007420)3.85351968
16Abnormal platelet function (HP:0011869)3.72610922
17Impaired platelet aggregation (HP:0003540)3.72610922
18Atonic seizures (HP:0010819)3.67157757
19Hepatocellular necrosis (HP:0001404)3.53300596
20Progressive inability to walk (HP:0002505)3.44273248
21Dyschromatopsia (HP:0007641)3.43710325
22Nonprogressive disorder (HP:0003680)3.42423164
23Poor suck (HP:0002033)3.32774561
24Poikilocytosis (HP:0004447)3.29068238
25Acanthocytosis (HP:0001927)3.28922524
26Hyperventilation (HP:0002883)3.16585460
27Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.08850719
28Abnormal protein N-linked glycosylation (HP:0012347)3.08850719
29Abnormal protein glycosylation (HP:0012346)3.08850719
30Abnormal glycosylation (HP:0012345)3.08850719
31Thyroid-stimulating hormone excess (HP:0002925)3.02256251
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.97848068
33Mitochondrial inheritance (HP:0001427)2.96879412
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.96849135
35Decreased central vision (HP:0007663)2.95839047
36Severe visual impairment (HP:0001141)2.90646665
37Myokymia (HP:0002411)2.87831749
38Prolonged partial thromboplastin time (HP:0003645)2.81593606
39Focal seizures (HP:0007359)2.78778625
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77897608
41Abnormality of alanine metabolism (HP:0010916)2.77897608
42Hyperalaninemia (HP:0003348)2.77897608
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77742041
44Hepatic necrosis (HP:0002605)2.75971147
45Increased hepatocellular lipid droplets (HP:0006565)2.71631882
46Abnormal pupillary function (HP:0007686)2.69916998
47Acute necrotizing encephalopathy (HP:0006965)2.67773545
48Abnormal mitochondria in muscle tissue (HP:0008316)2.67299322
49Prolonged bleeding time (HP:0003010)2.66287164
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61231319
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61231319
52Inability to walk (HP:0002540)2.61136419
533-Methylglutaconic aciduria (HP:0003535)2.60894145
54Cortical visual impairment (HP:0100704)2.58482167
55Increased CSF lactate (HP:0002490)2.57622543
56Episodic fever (HP:0001954)2.57018610
57Type 2 muscle fiber atrophy (HP:0003554)2.55098202
58Polyphagia (HP:0002591)2.53921868
59Paralysis (HP:0003470)2.53492532
60Conjunctival telangiectasia (HP:0000524)2.52915258
61Abnormal hair whorl (HP:0010721)2.52429521
62Blue irides (HP:0000635)2.51820360
63Oligomenorrhea (HP:0000876)2.51750450
64Ragged-red muscle fibers (HP:0003200)2.51148183
65Abnormality of the common coagulation pathway (HP:0010990)2.49301856
66Abnormality of aromatic amino acid family metabolism (HP:0004338)2.48574781
67Absence seizures (HP:0002121)2.48531531
68Lipid accumulation in hepatocytes (HP:0006561)2.44637685
69Increased intramyocellular lipid droplets (HP:0012240)2.43266526
70Tinnitus (HP:0000360)2.41324690
71Panhypogammaglobulinemia (HP:0003139)2.40327588
72Abnormality of macrophages (HP:0004311)2.39480141
73Renal Fanconi syndrome (HP:0001994)2.38998435
74Dialeptic seizures (HP:0011146)2.31080961
75Encephalitis (HP:0002383)2.28495247
76Spontaneous abortion (HP:0005268)2.28178694
77Abnormal rod and cone electroretinograms (HP:0008323)2.24907815
78Agitation (HP:0000713)2.23333796
79Type II lissencephaly (HP:0007260)2.23313129
80Retinal dysplasia (HP:0007973)2.22827512
81Bruising susceptibility (HP:0000978)2.22672154
82Abnormality of cells of the erythroid lineage (HP:0012130)2.20740424
83Abnormal number of erythroid precursors (HP:0012131)2.20206587
84Progressive macrocephaly (HP:0004481)2.14790526
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14371470
86Increased density of long bones (HP:0006392)2.13538498
87Muscle fiber atrophy (HP:0100295)2.13512828
88Meningitis (HP:0001287)2.13405918
89Abnormal eating behavior (HP:0100738)2.13060806
90Visual hallucinations (HP:0002367)2.12720119
91Horizontal nystagmus (HP:0000666)2.11960722
92Gaze-evoked nystagmus (HP:0000640)2.11784627
93Esotropia (HP:0000565)2.09846146
94Eczematoid dermatitis (HP:0000976)2.07538632
95Decreased muscle mass (HP:0003199)2.07053867
96Hypochromic microcytic anemia (HP:0004840)2.06150415
97Elevated erythrocyte sedimentation rate (HP:0003565)2.05959442
98Acute encephalopathy (HP:0006846)2.04873583
99Anxiety (HP:0000739)2.04804165
100Abolished electroretinogram (ERG) (HP:0000550)2.04318027
101Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04132461
102Increased muscle lipid content (HP:0009058)2.03726487
103Progressive cerebellar ataxia (HP:0002073)2.01269913
104Optic disc pallor (HP:0000543)2.01035652
105Obstructive lung disease (HP:0006536)2.00344202
106Chronic obstructive pulmonary disease (HP:0006510)2.00344202
107Dynein arm defect of respiratory motile cilia (HP:0012255)2.00143544
108Absent/shortened dynein arms (HP:0200106)2.00143544
109Generalized tonic-clonic seizures (HP:0002069)1.99158624
110Retinal atrophy (HP:0001105)1.98156779
111Exertional dyspnea (HP:0002875)1.98117224
112Eosinophilia (HP:0001880)1.97130727
113Depression (HP:0000716)1.96966959
114Abnormal delayed hypersensitivity skin test (HP:0002963)1.96601985
115Lactic acidosis (HP:0003128)1.96066294
116Abnormality of lateral ventricle (HP:0030047)1.95939361
117Dysautonomia (HP:0002459)1.94164736
118Increased IgM level (HP:0003496)1.93953893
119Abnormality of the heme biosynthetic pathway (HP:0010472)1.93637897
120Agammaglobulinemia (HP:0004432)1.93121429
121Aplasia/Hypoplasia of the fovea (HP:0008060)1.92970026
122Hypoplasia of the fovea (HP:0007750)1.92970026
123Abnormality of transition element cation homeostasis (HP:0011030)1.91127050
124Leukocytosis (HP:0001974)1.90666970
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89462777
126Cerebral edema (HP:0002181)1.89460049
127Abnormality of the renal cortex (HP:0011035)1.88919222
128Pancreatic cysts (HP:0001737)1.88757483
129Epileptic encephalopathy (HP:0200134)1.87180752
130Abnormal ciliary motility (HP:0012262)1.86176175
131Abnormality of eosinophils (HP:0001879)1.85414565
132Molar tooth sign on MRI (HP:0002419)1.85067445
133Abnormality of midbrain morphology (HP:0002418)1.85067445
134Bradycardia (HP:0001662)1.84907028
135Absent speech (HP:0001344)1.83750418
136Joint hemorrhage (HP:0005261)1.83689955
137Infertility (HP:0000789)1.82943097
138Limb dystonia (HP:0002451)1.82304646
139Abnormality of iron homeostasis (HP:0011031)1.81309410
140Recurrent abscess formation (HP:0002722)1.80954683
141Attenuation of retinal blood vessels (HP:0007843)1.80920522
142Thoracic kyphosis (HP:0002942)1.80856472
143Abnormal auditory evoked potentials (HP:0006958)1.80652811
144Epidermoid cyst (HP:0200040)1.80279783
145Chronic mucocutaneous candidiasis (HP:0002728)1.80100417
146Recurrent cutaneous fungal infections (HP:0011370)1.80100417
147Status epilepticus (HP:0002133)1.79476854
148Flat occiput (HP:0005469)1.79349354
149Abnormality of the prostate (HP:0008775)1.79279366
150Renal cortical cysts (HP:0000803)1.79086111
151Chest pain (HP:0100749)1.78717830
152IgG deficiency (HP:0004315)1.78565429
153Medial flaring of the eyebrow (HP:0010747)1.78137398
154Protruding tongue (HP:0010808)1.75244155
155Hypomagnesemia (HP:0002917)1.75216223
156Action tremor (HP:0002345)1.75164828
157Granulocytopenia (HP:0001913)1.74320371
158Truncal ataxia (HP:0002078)1.73653988
159Autoimmune hemolytic anemia (HP:0001890)1.72834459
160* Joint swelling (HP:0001386)1.72560158
161Congenital stationary night blindness (HP:0007642)1.71903296
162Hypophosphatemic rickets (HP:0004912)1.71280144
163Increased serum lactate (HP:0002151)1.71260111
164Microcytic anemia (HP:0001935)1.71106383
165Gait imbalance (HP:0002141)1.70414685
166Nephrogenic diabetes insipidus (HP:0009806)1.69395219
167Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67662570
168Generalized aminoaciduria (HP:0002909)1.67059111
169Abnormality of T cell number (HP:0011839)1.66018627
170T lymphocytopenia (HP:0005403)1.64882046
171Abnormality of the fovea (HP:0000493)1.64566842
172Recurrent bacterial skin infections (HP:0005406)1.62613741
173Retrobulbar optic neuritis (HP:0100654)1.61386772
174Optic neuritis (HP:0100653)1.61386772
175Abnormal respiratory epithelium morphology (HP:0012253)1.58252105
176Abnormal respiratory motile cilium morphology (HP:0005938)1.58252105
177Arterial thrombosis (HP:0004420)1.58186041
178Hepatosplenomegaly (HP:0001433)1.57517759
179Papillary thyroid carcinoma (HP:0002895)1.54574851
180Arthropathy (HP:0003040)1.52391922
181Ventricular fibrillation (HP:0001663)1.51738757
182Failure to thrive in infancy (HP:0001531)1.50470755
183Thrombophlebitis (HP:0004418)1.50122956
184Cerebral hemorrhage (HP:0001342)1.49462963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.36349730
2TNIK5.24505363
3MST43.99279699
4CAMKK23.80597773
5MAP2K73.67682300
6MAP3K123.64144888
7NTRK33.52462099
8CASK3.21435524
9FRK2.75385381
10TRIM282.63995652
11ACVR1B2.50582497
12PTK2B2.29401872
13FES2.27299574
14BMPR1B2.21235443
15BMX2.15206290
16KIT2.14064862
17MAP3K41.91113037
18GRK61.89744596
19NUAK11.88782749
20NME21.88651767
21ZAP701.70331673
22CAMKK11.63247846
23CAMK11.61070701
24MAP2K41.58722951
25CSNK1G31.54994046
26ADRBK21.54159120
27NLK1.52816535
28GRK71.51939909
29CAMK1G1.50760790
30CDK191.50570074
31ITK1.43492816
32PINK11.39633380
33CAMK1D1.39186198
34EIF2AK11.36991545
35TEC1.36750492
36IRAK31.30454112
37STK161.30355313
38GRK11.29733440
39CSNK1G21.29140263
40CSNK1G11.20268881
41MAP2K31.19584888
42MAPK131.17866477
43MINK11.17437239
44NTRK21.13648843
45CSK1.10661390
46CSNK1A1L1.07077602
47FGR1.06779331
48PLK21.06350490
49MATK1.05752754
50DAPK21.05386824
51STK31.02465813
52MAP3K51.01225347
53TBK11.00694148
54EIF2AK30.98720620
55YES10.96706372
56PIM20.95929840
57MAP4K20.94477901
58MARK10.93157385
59ERBB40.91059553
60MARK30.90983042
61BLK0.88935814
62TIE10.88329449
63PAK30.87685152
64SYK0.85467536
65PDK30.85286846
66PDK40.85286846
67NTRK10.84360489
68TAOK30.83143223
69MAPK40.80193881
70IRAK20.78920913
71IRAK40.78030239
72ARAF0.76896247
73MAP3K10.76871710
74ICK0.74959742
75PRKCQ0.74825196
76CAMK40.74130812
77BMPR20.73695523
78GRK50.73053080
79MKNK20.72831997
80MAP3K110.71733300
81MYLK0.70103053
82BTK0.69928642
83PRKCG0.69458192
84IKBKE0.68352942
85PRKG20.68030503
86TAOK20.67317746
87UHMK10.66037782
88TXK0.65224960
89TNK20.65154790
90MAP3K90.63213894
91FER0.61204370
92TLK10.60840137
93PRPF4B0.60056405
94CSF1R0.59421423
95OXSR10.56316749
96PDK20.55749728
97CAMK2G0.55172386
98IRAK10.53045300
99ZAK0.51381710
100ERBB20.51087482
101HIPK20.50990602
102TYK20.50792564
103MAPKAPK30.50086614
104CAMK2A0.49922196
105STK40.49750449
106PNCK0.49545093
107ADRBK10.49445163
108PDK10.49015359
109JAK10.48491071
110JAK20.48225514
111ILK0.46895820
112SGK20.46611219
113TAOK10.45810071
114PAK10.45572166
115CDK80.44385015
116DAPK30.43604183
117WNK40.43466352
118WNK30.43405267
119RIPK40.42861101
120IKBKB0.42697628
121SIK30.42588776
122DYRK20.41721353
123CDK30.39974861
124BCR0.39366104
125SIK20.39356504
126PRKG10.38915256
127EPHB10.37870717
128JAK30.37277061
129INSRR0.37180981
130CDK50.36912164
131PRKACA0.35941362
132PIK3CG0.35647129
133PRKCE0.35157883
134DAPK10.34937138
135PRKD10.34634700
136MAPK120.34612591
137MAP4K10.34149094
138MAP2K60.33780528
139LYN0.33705601
140FLT30.33496993
141STK380.32207951
142LCK0.31935399
143EPHA30.31504743
144BCKDK0.31250981
145PDGFRB0.30675029
146RET0.29987555
147RPS6KB10.28461389
148MAPKAPK50.26534704
149PHKG10.26348552
150PHKG20.26348552
151HCK0.25497709
152CAMK2B0.25293580
153PRKACG0.24489226
154PIM10.24095026

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.20655283
2Nicotine addiction_Homo sapiens_hsa050334.18902140
3Oxidative phosphorylation_Homo sapiens_hsa001903.36443143
4Synaptic vesicle cycle_Homo sapiens_hsa047213.13617697
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.86528152
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.83085373
7Nitrogen metabolism_Homo sapiens_hsa009102.81275389
8Parkinsons disease_Homo sapiens_hsa050122.46473785
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.37483331
10Collecting duct acid secretion_Homo sapiens_hsa049662.25880488
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15375940
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.11403161
13Taste transduction_Homo sapiens_hsa047422.09061372
14Alzheimers disease_Homo sapiens_hsa050102.04822721
15GABAergic synapse_Homo sapiens_hsa047271.96519918
16Arachidonic acid metabolism_Homo sapiens_hsa005901.93029429
17Linoleic acid metabolism_Homo sapiens_hsa005911.89138937
18T cell receptor signaling pathway_Homo sapiens_hsa046601.85435284
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84069992
20Chemokine signaling pathway_Homo sapiens_hsa040621.75813428
21Huntingtons disease_Homo sapiens_hsa050161.72848643
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70631547
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67024269
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65500851
25Ribosome_Homo sapiens_hsa030101.57814547
26Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.55883069
27Olfactory transduction_Homo sapiens_hsa047401.52114370
28Protein export_Homo sapiens_hsa030601.51339085
29Type I diabetes mellitus_Homo sapiens_hsa049401.47528154
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45596626
31Morphine addiction_Homo sapiens_hsa050321.44059638
32Vibrio cholerae infection_Homo sapiens_hsa051101.42976169
33Glutamatergic synapse_Homo sapiens_hsa047241.42591598
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39990917
35Circadian entrainment_Homo sapiens_hsa047131.33410714
36Glycerolipid metabolism_Homo sapiens_hsa005611.32026458
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31771672
38N-Glycan biosynthesis_Homo sapiens_hsa005101.29256941
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28749271
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27295849
41Amphetamine addiction_Homo sapiens_hsa050311.20092865
42Rheumatoid arthritis_Homo sapiens_hsa053231.18909030
43Pyruvate metabolism_Homo sapiens_hsa006201.17889574
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17568268
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17500246
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17168321
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.17155341
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16947245
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15848389
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13795830
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11349794
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10429200
53Primary immunodeficiency_Homo sapiens_hsa053401.07696829
54Butanoate metabolism_Homo sapiens_hsa006501.07019595
55Osteoclast differentiation_Homo sapiens_hsa043801.06469286
56Sulfur relay system_Homo sapiens_hsa041221.04031972
57Phagosome_Homo sapiens_hsa041451.01937989
58beta-Alanine metabolism_Homo sapiens_hsa004101.01605204
59Serotonergic synapse_Homo sapiens_hsa047261.00585169
60Glycerophospholipid metabolism_Homo sapiens_hsa005641.00166193
61Basal transcription factors_Homo sapiens_hsa030220.99570701
62Fatty acid elongation_Homo sapiens_hsa000620.98781584
63Cocaine addiction_Homo sapiens_hsa050300.96750716
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96429616
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94113256
66Dopaminergic synapse_Homo sapiens_hsa047280.93490269
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93244509
68Fat digestion and absorption_Homo sapiens_hsa049750.92864270
69Salivary secretion_Homo sapiens_hsa049700.91131763
70Calcium signaling pathway_Homo sapiens_hsa040200.89941177
71Cholinergic synapse_Homo sapiens_hsa047250.88606963
72Endocytosis_Homo sapiens_hsa041440.88550500
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86747591
74Insulin secretion_Homo sapiens_hsa049110.86413480
75Autoimmune thyroid disease_Homo sapiens_hsa053200.85814635
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84962917
77Allograft rejection_Homo sapiens_hsa053300.84891210
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83454607
79Long-term depression_Homo sapiens_hsa047300.81142707
80Arginine biosynthesis_Homo sapiens_hsa002200.80919892
81Cardiac muscle contraction_Homo sapiens_hsa042600.80609036
82Ether lipid metabolism_Homo sapiens_hsa005650.80522520
83Acute myeloid leukemia_Homo sapiens_hsa052210.78886992
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78660314
85Long-term potentiation_Homo sapiens_hsa047200.76363942
86Measles_Homo sapiens_hsa051620.75785973
87ABC transporters_Homo sapiens_hsa020100.74350726
88Proteasome_Homo sapiens_hsa030500.74179861
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71452937
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70883311
91Phototransduction_Homo sapiens_hsa047440.69198696
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.68891107
93Folate biosynthesis_Homo sapiens_hsa007900.64911766
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64730396
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63533675
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62901447
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62575835
98Ras signaling pathway_Homo sapiens_hsa040140.59832566
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.59209867
100Retinol metabolism_Homo sapiens_hsa008300.58527772
101Starch and sucrose metabolism_Homo sapiens_hsa005000.58052918
102Propanoate metabolism_Homo sapiens_hsa006400.57935659
103Graft-versus-host disease_Homo sapiens_hsa053320.57622557
104Regulation of autophagy_Homo sapiens_hsa041400.56583071
105Metabolic pathways_Homo sapiens_hsa011000.56527926
106Shigellosis_Homo sapiens_hsa051310.56501473
107Pancreatic secretion_Homo sapiens_hsa049720.56362649
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.56215510
109Other glycan degradation_Homo sapiens_hsa005110.55103415
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53885802
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53826361
112Caffeine metabolism_Homo sapiens_hsa002320.52922766
113Complement and coagulation cascades_Homo sapiens_hsa046100.52191346
114Malaria_Homo sapiens_hsa051440.51894343
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.51847741
116Sulfur metabolism_Homo sapiens_hsa009200.50980617
117Glutathione metabolism_Homo sapiens_hsa004800.50659202
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.49462337
119Renin-angiotensin system_Homo sapiens_hsa046140.48654092
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.47763968
121B cell receptor signaling pathway_Homo sapiens_hsa046620.47558577
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.47434054
123Renin secretion_Homo sapiens_hsa049240.47114736
124PPAR signaling pathway_Homo sapiens_hsa033200.45137209
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.44500393
126Histidine metabolism_Homo sapiens_hsa003400.43998478
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43500856
128Legionellosis_Homo sapiens_hsa051340.41857307
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41738805
130Tryptophan metabolism_Homo sapiens_hsa003800.41297153
131cAMP signaling pathway_Homo sapiens_hsa040240.41240084
132Tuberculosis_Homo sapiens_hsa051520.41224289
133Rap1 signaling pathway_Homo sapiens_hsa040150.41131132
134Choline metabolism in cancer_Homo sapiens_hsa052310.40591015
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40463596
136Steroid biosynthesis_Homo sapiens_hsa001000.40453700
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39974138
138Alcoholism_Homo sapiens_hsa050340.38964090
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36026699
140Gastric acid secretion_Homo sapiens_hsa049710.36019295
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.35577398
142Asthma_Homo sapiens_hsa053100.34643689
143Peroxisome_Homo sapiens_hsa041460.33355711
144Hematopoietic cell lineage_Homo sapiens_hsa046400.32418132
145FoxO signaling pathway_Homo sapiens_hsa040680.31442819
146Chemical carcinogenesis_Homo sapiens_hsa052040.31070308
147Staphylococcus aureus infection_Homo sapiens_hsa051500.30545085
148Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30251813
149Thyroid cancer_Homo sapiens_hsa052160.30004462
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29998946
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.28406660
152Gap junction_Homo sapiens_hsa045400.27982953
153Phenylalanine metabolism_Homo sapiens_hsa003600.27947327

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