ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	reproduction (GO:0000003)	9.70823914
2	spermatid development (GO:0007286)	9.60528601
3	motile cilium assembly (GO:0044458)	9.26761741
4	cilium movement (GO:0003341)	8.48772412
5	regulation of cilium movement (GO:0003352)	8.34703930
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.84581595
7	sperm capacitation (GO:0048240)	7.70317451
8	male meiosis (GO:0007140)	7.58670496
9	single fertilization (GO:0007338)	7.46304591
10	piRNA metabolic process (GO:0034587)	7.42848236
11	synaptonemal complex organization (GO:0070193)	7.38277838
12	synaptonemal complex assembly (GO:0007130)	7.34457465
13	negative regulation of inclusion body assembly (GO:0090084)	6.71250379
14	spermatogenesis (GO:0007283)	6.45002867
15	male gamete generation (GO:0048232)	6.42658778
16	fertilization (GO:0009566)	6.26986300
17	organic cation transport (GO:0015695)	6.25957924
18	microtubule depolymerization (GO:0007019)	6.12899354
19	gamete generation (GO:0007276)	5.90877781
20	regulation of inclusion body assembly (GO:0090083)	5.60848845
21	spermatid nucleus differentiation (GO:0007289)	5.52842267
22	calcium ion-dependent exocytosis (GO:0017156)	5.41531226
23	ventricular system development (GO:0021591)	5.39353649
24	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.38192282
25	germ cell development (GO:0007281)	5.35304450
26	cell recognition (GO:0008037)	5.15659979
27	chromosome organization involved in meiosis (GO:0070192)	5.05563530
28	microtubule severing (GO:0051013)	5.05396693
29	regulation of microtubule-based movement (GO:0060632)	4.90937447
30	male meiosis I (GO:0007141)	4.76269112
31	DNA methylation involved in gamete generation (GO:0043046)	4.71175424
32	glycerol ether metabolic process (GO:0006662)	4.69965801
33	multicellular organismal reproductive process (GO:0048609)	4.65175943
34	chromosome condensation (GO:0030261)	4.58534358
35	seminiferous tubule development (GO:0072520)	4.47189797
36	meiotic nuclear division (GO:0007126)	4.39842341
37	DNA packaging (GO:0006323)	4.34847486
38	ether metabolic process (GO:0018904)	4.34330434
39	left/right pattern formation (GO:0060972)	4.16777189
40	sexual reproduction (GO:0019953)	4.11788581
41	single strand break repair (GO:0000012)	4.04416179
42	chaperone-mediated protein complex assembly (GO:0051131)	3.90046399
43	protein polyglutamylation (GO:0018095)	3.83418017
44	meiosis I (GO:0007127)	3.78719162
45	monoubiquitinated protein deubiquitination (GO:0035520)	3.76533668
46	multicellular organismal development (GO:0007275)	3.75615563
47	protein K11-linked deubiquitination (GO:0035871)	3.71395599
48	genitalia morphogenesis (GO:0035112)	3.68654893
49	meiotic cell cycle (GO:0051321)	3.44957746
50	protein localization to cilium (GO:0061512)	3.40326724
51	sequestering of actin monomers (GO:0042989)	3.20819779
52	regulation of spindle checkpoint (GO:0090231)	3.19274238
53	microtubule polymerization or depolymerization (GO:0031109)	3.12074894
54	amino-acid betaine transport (GO:0015838)	3.10880852
55	carnitine transport (GO:0015879)	3.10880852
56	protein refolding (GO:0042026)	3.05319930
57	glycolytic process (GO:0006096)	3.02288250
58	intraciliary transport (GO:0042073)	3.00706521
59	nucleoside diphosphate phosphorylation (GO:0006165)	2.97957012
60	carnitine transmembrane transport (GO:1902603)	2.97705927
61	synapsis (GO:0007129)	2.97563480
62	nucleus organization (GO:0006997)	2.94808399
63	microtubule-based movement (GO:0007018)	2.93838523
64	polyol catabolic process (GO:0046174)	2.93586591
65	cilium organization (GO:0044782)	2.92746122
66	alditol metabolic process (GO:0019400)	2.92484288
67	positive regulation of macrophage activation (GO:0043032)	2.90048619
68	meiotic cell cycle process (GO:1903046)	2.84739400
69	cilium assembly (GO:0042384)	2.80802941
70	GTP biosynthetic process (GO:0006183)	2.80738807
71	cellular component assembly involved in morphogenesis (GO:0010927)	2.80522663
72	negative regulation of organelle assembly (GO:1902116)	2.78339357
73	mitotic sister chromatid cohesion (GO:0007064)	2.76398770
74	lactate metabolic process (GO:0006089)	2.71281213
75	cilium morphogenesis (GO:0060271)	2.70376639
76	axoneme assembly (GO:0035082)	2.70026229
77	interferon-gamma secretion (GO:0072643)	2.69839304
78	gene silencing by RNA (GO:0031047)	2.67494093
79	centriole assembly (GO:0098534)	2.61703103
80	peptidyl-glutamic acid modification (GO:0018200)	2.58276535
81	glycerol metabolic process (GO:0006071)	2.50337637
82	UTP biosynthetic process (GO:0006228)	2.50315645
83	polyamine biosynthetic process (GO:0006596)	2.45159656
84	regulation of cilium assembly (GO:1902017)	2.45003312
85	chromatin silencing (GO:0006342)	2.41802149
86	regulation of centriole replication (GO:0046599)	2.41289651
87	sperm motility (GO:0030317)	13.7368018
88	fusion of sperm to egg plasma membrane (GO:0007342)	13.6533358
89	cell wall macromolecule metabolic process (GO:0044036)	13.6362333
90	cell wall macromolecule catabolic process (GO:0016998)	13.6362333
91	acrosome assembly (GO:0001675)	12.4509902
92	sperm-egg recognition (GO:0035036)	11.8934336
93	acrosome reaction (GO:0007340)	11.6872530
94	multicellular organism reproduction (GO:0032504)	11.3054829
95	binding of sperm to zona pellucida (GO:0007339)	10.7891640
96	cell-cell recognition (GO:0009988)	10.6579841
97	cilium or flagellum-dependent cell motility (GO:0001539)	10.6066203
98	plasma membrane fusion (GO:0045026)	10.3978638
99	epithelial cilium movement (GO:0003351)	10.1705357
100	axonemal dynein complex assembly (GO:0070286)	10.0640350

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.54774028
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.63801771
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.19937057
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.23515268
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.08693949
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.78442243
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.49008996
8	VDR_22108803_ChIP-Seq_LS180_Human	2.30248449
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27740139
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.21512520
11	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.15645082
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.08228712
13	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.07465258
14	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.03502683
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03229076
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.01035719
17	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.92017859
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78318896
19	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.76204608
20	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.72853420
21	STAT1_17558387_ChIP-Seq_HELA_Human	1.68795556
22	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.68472196
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64060790
24	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63022154
25	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.58975622
26	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.58565308
27	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.55651860
28	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.55451455
29	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.52560366
30	KDM2B_26808549_Chip-Seq_REH_Human	1.51430276
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51170688
32	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.50174031
33	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.45693626
34	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.44917488
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42654502
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.42406723
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42406723
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33891360
39	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33373419
40	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.31716106
41	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.30955301
42	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.29747996
43	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.29084411
44	P53_21459846_ChIP-Seq_SAOS-2_Human	1.27346644
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.26560710
46	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.25684237
47	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.25269218
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.24822561
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20731230
50	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19407215
51	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18922880
52	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.18172713
53	GF1_26923725_Chip-Seq_HPCs_Mouse	1.18039732
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17544709
55	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.15477484
56	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.13980210
57	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.13231245
58	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.11751673
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11686968
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11686968
61	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.10865288
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10571733
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09180768
64	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.09059931
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08641374
66	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.06935290
67	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06826259
68	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.05862341
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05352653
70	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.05300994
71	P300_18555785_Chip-Seq_ESCs_Mouse	1.04738848
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04378051
73	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.03732136
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02959380
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01691455
76	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.01012925
77	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00845296
78	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00691956
79	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00347047
80	ERG_20517297_ChIP-Seq_VCAP_Human	1.00144161
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99541584
82	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.98701270
83	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.98414467
84	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.97665436
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96623339
86	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.96527773
87	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.96339014
88	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.95452924
89	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.94305239
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.93320519
91	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.93163884
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.91951122
93	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.90508754
94	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.90205197
95	SOX9_26525672_Chip-Seq_HEART_Mouse	0.88961511
96	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.88654695
97	PU1_27457419_Chip-Seq_LIVER_Mouse	0.88583189
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.88581131
99	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.88441070
100	TAF15_26573619_Chip-Seq_HEK293_Human	0.88071839

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.13197695
2	MP0001929_abnormal_gametogenesis	5.60110463
3	MP0008877_abnormal_DNA_methylation	4.19578069
4	MP0002210_abnormal_sex_determination	3.48378823
5	MP0002161_abnormal_fertility/fecundity	3.32065716
6	MP0001145_abnormal_male_reproductive	2.97601316
7	MP0002653_abnormal_ependyma_morphology	2.79497783
8	MP0000653_abnormal_sex_gland	2.57854398
9	MP0005670_abnormal_white_adipose	2.51735073
10	MP0005410_abnormal_fertilization	16.3837955
11	MP0005623_abnormal_meninges_morphology	1.94674783
12	MP0002160_abnormal_reproductive_system	1.46827359
13	MP0003646_muscle_fatigue	1.38689152
14	MP0004233_abnormal_muscle_weight	1.37661904
15	MP0002282_abnormal_trachea_morphology	1.31794217
16	MP0008058_abnormal_DNA_repair	1.21473204
17	MP0009046_muscle_twitch	1.19425789
18	MP0001765_abnormal_ion_homeostasis	1.13554177
19	MP0001984_abnormal_olfaction	0.99452050
20	MP0005647_abnormal_sex_gland	0.95213999
21	MP0002234_abnormal_pharynx_morphology	0.80007172
22	MP0005389_reproductive_system_phenotype	0.75806655
23	MP0003011_delayed_dark_adaptation	0.73316867
24	MP0008995_early_reproductive_senescence	0.69069590
25	MP0010094_abnormal_chromosome_stability	0.68352321
26	MP0000569_abnormal_digit_pigmentation	0.64919713
27	MP0008057_abnormal_DNA_replication	0.64612406
28	MP0005636_abnormal_mineral_homeostasis	0.64494068
29	MP0005377_hearing/vestibular/ear_phenot	0.55980203
30	MP0003878_abnormal_ear_physiology	0.55980203
31	MP0004036_abnormal_muscle_relaxation	0.53276964
32	MP0003115_abnormal_respiratory_system	0.53245782
33	MP0001324_abnormal_eye_pigmentation	0.52525882
34	MP0002928_abnormal_bile_duct	0.51721663
35	MP0000358_abnormal_cell_content/	0.50610610
36	MP0001293_anophthalmia	0.49491356
37	MP0003699_abnormal_female_reproductive	0.48284038
38	MP0003950_abnormal_plasma_membrane	0.46290817
39	MP0005666_abnormal_adipose_tissue	0.45610957
40	MP0001764_abnormal_homeostasis	0.44998348
41	MP0002736_abnormal_nociception_after	0.41726090
42	MP0001545_abnormal_hematopoietic_system	0.41400988
43	MP0005397_hematopoietic_system_phenotyp	0.41400988
44	MP0002269_muscular_atrophy	0.40765424
45	MP0005253_abnormal_eye_physiology	0.40506591
46	MP0003329_amyloid_beta_deposits	0.40405173
47	MP0005551_abnormal_eye_electrophysiolog	0.40177475
48	MP0004019_abnormal_vitamin_homeostasis	0.39396089
49	MP0004133_heterotaxia	0.38347004
50	MP0006036_abnormal_mitochondrial_physio	0.37640079
51	MP0009278_abnormal_bone_marrow	0.34127931
52	MP0001119_abnormal_female_reproductive	0.32528720
53	MP0008007_abnormal_cellular_replicative	0.32504637
54	MP0003633_abnormal_nervous_system	0.32383102
55	MP0003786_premature_aging	0.31561582
56	MP0005391_vision/eye_phenotype	0.31526913
57	MP0009115_abnormal_fat_cell	0.31275231
58	MP0002971_abnormal_brown_adipose	0.30663459
59	MP0003111_abnormal_nucleus_morphology	0.30156317
60	MP0010307_abnormal_tumor_latency	0.29706409
61	MP0003879_abnormal_hair_cell	0.27814203
62	MP0002139_abnormal_hepatobiliary_system	0.27615202
63	MP0002102_abnormal_ear_morphology	0.27025284
64	MP0001730_embryonic_growth_arrest	0.26266448
65	MP0004811_abnormal_neuron_physiology	0.25214256
66	MP0000534_abnormal_ureter_morphology	0.24123344
67	MP0003631_nervous_system_phenotype	0.23604125
68	MP0003861_abnormal_nervous_system	0.22722097
69	MP0001968_abnormal_touch/_nociception	0.21203952
70	MP0002152_abnormal_brain_morphology	0.20527117
71	MP0000313_abnormal_cell_death	0.20205610
72	MP0004808_abnormal_hematopoietic_stem	0.20192966
73	MP0000604_amyloidosis	0.19848946
74	MP0002169_no_abnormal_phenotype	0.19762575
75	MP0002873_normal_phenotype	0.19509059
76	MP0002132_abnormal_respiratory_system	0.18547255
77	MP0005174_abnormal_tail_pigmentation	0.18127738
78	MP0006035_abnormal_mitochondrial_morpho	0.17234501
79	MP0002092_abnormal_eye_morphology	0.17017389
80	MP0003948_abnormal_gas_homeostasis	0.16941658
81	MP0004043_abnormal_pH_regulation	0.16400171
82	MP0002229_neurodegeneration	0.15879419
83	MP0004742_abnormal_vestibular_system	0.15699546
84	MP0004145_abnormal_muscle_electrophysio	0.15290690
85	MP0002084_abnormal_developmental_patter	0.15010771
86	MP0002405_respiratory_system_inflammati	0.14927214
87	MP0008875_abnormal_xenobiotic_pharmacok	0.14892170
88	MP0004084_abnormal_cardiac_muscle	0.14529284
89	MP0003942_abnormal_urinary_system	0.14517348
90	MP0005319_abnormal_enzyme/_coenzyme	0.13784125
91	MP0004134_abnormal_chest_morphology	0.13752552
92	MP0000462_abnormal_digestive_system	0.13703088
93	MP0003787_abnormal_imprinting	0.13577130
94	MP0002295_abnormal_pulmonary_circulatio	0.13077371
95	MP0000001_mammalian_phenotype	0.12745876
96	MP0005365_abnormal_bile_salt	0.12740427
97	MP0005195_abnormal_posterior_eye	0.12360041
98	MP0002693_abnormal_pancreas_physiology	0.11957115
99	MP0006072_abnormal_retinal_apoptosis	0.10902078
100	MP0009697_abnormal_copulation	0.10894791

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.62437484
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.11248353
3	Abnormal respiratory epithelium morphology (HP:0012253)	9.11248353
4	Abnormal ciliary motility (HP:0012262)	7.78240110
5	Rhinitis (HP:0012384)	7.77056690
6	Chronic bronchitis (HP:0004469)	7.49232026
7	Infertility (HP:0000789)	6.66045102
8	Nasal polyposis (HP:0100582)	6.53325565
9	Abnormality of the nasal mucosa (HP:0000433)	5.36615619
10	Bronchitis (HP:0012387)	4.72897019
11	Bronchiectasis (HP:0002110)	4.58967257
12	Male infertility (HP:0003251)	4.30499617
13	Nephronophthisis (HP:0000090)	4.19216145
14	Recurrent sinusitis (HP:0011108)	3.48210333
15	Abnormal spermatogenesis (HP:0008669)	3.42891823
16	Recurrent otitis media (HP:0000403)	3.38682826
17	Abnormality of the renal medulla (HP:0100957)	3.17447766
18	Recurrent bronchitis (HP:0002837)	2.88673680
19	Tubulointerstitial nephritis (HP:0001970)	2.79060455
20	Abnormality of midbrain morphology (HP:0002418)	2.64372174
21	Molar tooth sign on MRI (HP:0002419)	2.64372174
22	Medial flaring of the eyebrow (HP:0010747)	2.56322468
23	Tubular atrophy (HP:0000092)	2.54327229
24	Tubulointerstitial abnormality (HP:0001969)	2.39789022
25	Impulsivity (HP:0100710)	2.37529490
26	Azoospermia (HP:0000027)	2.30769688
27	Gonadotropin excess (HP:0000837)	2.25551039
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.7737508
29	Absent/shortened dynein arms (HP:0200106)	13.1501815
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.1501815
31	Abnormal gallbladder physiology (HP:0012438)	1.99688040
32	Cholecystitis (HP:0001082)	1.99688040
33	Postaxial foot polydactyly (HP:0001830)	1.94672768
34	Dyschromatopsia (HP:0007641)	1.94434693
35	Tubulointerstitial fibrosis (HP:0005576)	1.93924857
36	Decreased central vision (HP:0007663)	1.83516667
37	Congenital hepatic fibrosis (HP:0002612)	1.80563009
38	Abnormality of the lower motor neuron (HP:0002366)	1.78748231
39	Stage 5 chronic kidney disease (HP:0003774)	1.77816760
40	Fibular hypoplasia (HP:0003038)	1.77451498
41	Polydipsia (HP:0001959)	1.72439660
42	Abnormal drinking behavior (HP:0030082)	1.72439660
43	Abnormality of the renal cortex (HP:0011035)	1.68874021
44	Abnormal biliary tract physiology (HP:0012439)	1.68449913
45	Bile duct proliferation (HP:0001408)	1.68449913
46	Spastic tetraparesis (HP:0001285)	1.67853498
47	Short ribs (HP:0000773)	1.64124804
48	Abnormality of renal excretion (HP:0011036)	1.63523709
49	Abnormality of permanent molar morphology (HP:0011071)	1.60003927
50	Abnormality of the dental root (HP:0006486)	1.60003927
51	Taurodontia (HP:0000679)	1.60003927
52	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.59877582
53	Chronic sinusitis (HP:0011109)	1.57201616
54	Microglossia (HP:0000171)	1.56482933
55	Oculomotor apraxia (HP:0000657)	1.56165618
56	Renal dysplasia (HP:0000110)	1.53858082
57	Facial cleft (HP:0002006)	1.53420138
58	Pancreatic fibrosis (HP:0100732)	1.52790325
59	Heterotopia (HP:0002282)	1.52775154
60	Postaxial hand polydactyly (HP:0001162)	1.50398568
61	Abnormality of molar (HP:0011077)	1.49783695
62	Abnormality of molar morphology (HP:0011070)	1.49783695
63	Absent frontal sinuses (HP:0002688)	1.49653725
64	Choroideremia (HP:0001139)	1.49184562
65	Amyotrophic lateral sclerosis (HP:0007354)	1.48034812
66	Cystic liver disease (HP:0006706)	1.47725755
67	Abnormality of the dental pulp (HP:0006479)	1.47616039
68	Abnormality of dentin (HP:0010299)	1.45224355
69	Congenital primary aphakia (HP:0007707)	1.44230805
70	Gait imbalance (HP:0002141)	1.43633623
71	Asymmetric septal hypertrophy (HP:0001670)	1.43123137
72	Bell-shaped thorax (HP:0001591)	1.42290950
73	Aplasia/Hypoplasia of the lens (HP:0008063)	1.41785810
74	Congenital malformation of the right heart (HP:0011723)	1.39900052
75	Double outlet right ventricle (HP:0001719)	1.39900052
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.38601343
77	J-shaped sella turcica (HP:0002680)	1.38413126
78	Deformed sella turcica (HP:0002681)	1.35892319
79	Bundle branch block (HP:0011710)	1.35157453
80	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.32179590
81	Hemorrhage of the eye (HP:0011885)	1.32108369
82	Median cleft lip (HP:0000161)	1.30270451
83	Abnormal urine output (HP:0012590)	1.29534012
84	Abnormality of saccadic eye movements (HP:0000570)	1.28222909
85	Abnormality of ocular smooth pursuit (HP:0000617)	1.26652978
86	Impaired proprioception (HP:0010831)	1.25565151
87	Constricted visual fields (HP:0001133)	1.25053777
88	Absent epiphyses (HP:0010577)	1.24848543
89	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.24848543
90	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.24594842
91	Short thorax (HP:0010306)	1.22827202
92	Nephrogenic diabetes insipidus (HP:0009806)	1.21393519
93	Neurofibrillary tangles (HP:0002185)	1.21194998
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.20453587
95	Cerebellar dysplasia (HP:0007033)	1.20272595
96	Nephropathy (HP:0000112)	1.19732561
97	True hermaphroditism (HP:0010459)	1.19509666
98	Vascular calcification (HP:0004934)	1.18996561
99	Exercise-induced myalgia (HP:0003738)	1.18135507
100	Tongue fasciculations (HP:0001308)	1.17152699

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	8.82439169
2	PDK4	8.82439169
3	PDK2	5.72381725
4	TESK1	5.45453454
5	PRKD3	4.15467550
6	ICK	3.74033661
7	WNK4	2.32160292
8	PTK2B	2.27539028
9	STK39	2.26912791
10	PNCK	1.75791626
11	STK38	1.68391455
12	NEK2	1.53084743
13	DYRK1B	1.35652252
14	PDK1	1.18171123
15	CCNB1	0.84914647
16	WNK1	0.84640872
17	DYRK3	0.83376866
18	MAPK15	0.81682511
19	IRAK1	0.80407251
20	TYRO3	0.80198351
21	LMTK2	0.76558927
22	PASK	0.74055317
23	STK3	0.68429764
24	PDPK1	0.66330441
25	TTK	0.64119236
26	STK38L	0.58458013
27	CHEK2	0.57662731
28	RIPK4	0.55139392
29	PINK1	0.53346431
30	MAP2K6	0.52422805
31	EEF2K	0.50469866
32	WEE1	0.50038249
33	TESK2	0.45754086
34	BRSK2	0.45559837
35	CHEK1	0.40993797
36	IRAK2	0.40699938
37	CAMK1G	0.37338430
38	NTRK2	0.36475941
39	MUSK	0.34369765
40	PAK1	0.33689003
41	ATR	0.32502175
42	PRKCG	0.31609680
43	PLK4	0.28129446
44	ATM	0.27490611
45	MAP3K10	0.26562467
46	CDC7	0.25691496
47	MAPKAPK5	0.23929919
48	MTOR	0.21736112
49	PAK2	0.21226004
50	CAMKK1	0.20996182
51	NEK6	0.20329456
52	BRSK1	0.18666646
53	PLK1	0.18341720
54	MARK2	0.18114937
55	PRKAA1	0.17317962
56	PRKCZ	0.15988258
57	RPS6KB1	0.15758968
58	PRKCQ	0.15663831
59	PRKG2	0.13905264
60	ZAP70	0.12412658
61	MAP2K7	0.12392720
62	CDK15	0.11110420
63	MARK3	0.10227066
64	PAK4	0.08874876
65	CDK18	0.08461976
66	CDK11A	0.08147384
67	MAP3K4	0.08121613
68	CSNK2A1	0.07743940
69	PDGFRB	0.07512523
70	STK10	0.06749830
71	RIPK1	0.06700250
72	RPS6KA1	0.06343752
73	BRAF	0.06306937
74	GSK3B	0.05627607
75	PRKG1	0.05204612
76	STK11	0.04594289
77	PRKACG	0.04572764
78	BMPR1B	0.04303039
79	CDK14	0.04294011
80	CSNK2A2	0.04089442
81	CDK1	0.03828556
82	YES1	0.03514323
83	MAPK8	0.02984216
84	CDK2	0.02862569
85	PKN1	0.02769648
86	CSF1R	0.02353756
87	CAMK2A	0.01813488
88	CSNK1D	0.01787218
89	PRKCD	0.01120502
90	CDK12	0.01087126
91	PRKCA	0.00336682
92	PRKCB	0.00179319
93	PIM1	0.00070221
94	EGFR	0.00063088
95	MAP3K5	-0.0229838
96	CDK6	-0.0203636
97	PRKACB	-0.0151055
98	AURKA	-0.0138685
99	PRKDC	-0.0110902
100	WNK3	-0.0077928

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.45514382
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.16387892
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.90501083
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.67313450
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.02088139
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.91945109
7	Propanoate metabolism_Homo sapiens_hsa00640	2.80623433
8	Glucagon signaling pathway_Homo sapiens_hsa04922	2.64851748
9	Basal transcription factors_Homo sapiens_hsa03022	2.50432427
10	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.41381192
11	Pentose phosphate pathway_Homo sapiens_hsa00030	2.40816934
12	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.13014151
13	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.99144689
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.97809859
15	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.95833330
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.94113752
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.84257626
18	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.78704538
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.74653005
20	Oocyte meiosis_Homo sapiens_hsa04114	1.73876564
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.70291117
22	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.61167045
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60702031
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.54959705
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.54866933
26	Carbon metabolism_Homo sapiens_hsa01200	1.51246972
27	Amphetamine addiction_Homo sapiens_hsa05031	1.45034431
28	Mineral absorption_Homo sapiens_hsa04978	1.43100972
29	Fat digestion and absorption_Homo sapiens_hsa04975	1.42332621
30	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.42122422
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.33999502
32	Huntingtons disease_Homo sapiens_hsa05016	1.32956908
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.31333344
34	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.29503057
35	Fatty acid degradation_Homo sapiens_hsa00071	1.26325914
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.23279629
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.22715713
38	Renin secretion_Homo sapiens_hsa04924	1.11324403
39	Purine metabolism_Homo sapiens_hsa00230	1.06471721
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.05467977
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03955127
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.03219322
43	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.00607569
44	mRNA surveillance pathway_Homo sapiens_hsa03015	1.00273185
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94672901
46	Renin-angiotensin system_Homo sapiens_hsa04614	0.93028960
47	Glutathione metabolism_Homo sapiens_hsa00480	0.92887274
48	RNA transport_Homo sapiens_hsa03013	0.82668588
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79999406
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79148796
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77964940
52	Insulin secretion_Homo sapiens_hsa04911	0.73103858
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70776048
54	ABC transporters_Homo sapiens_hsa02010	0.70246676
55	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.68586667
56	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67052855
57	Long-term potentiation_Homo sapiens_hsa04720	0.66811906
58	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.65175912
59	Bile secretion_Homo sapiens_hsa04976	0.65158315
60	Estrogen signaling pathway_Homo sapiens_hsa04915	0.65073206
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60084402
62	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.59883591
63	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.55443774
64	Legionellosis_Homo sapiens_hsa05134	0.54794598
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.53597025
66	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.53560335
67	Pancreatic secretion_Homo sapiens_hsa04972	0.52039457
68	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51404424
69	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.50268790
70	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.47993173
71	Sulfur metabolism_Homo sapiens_hsa00920	0.47754623
72	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.46705936
73	Protein digestion and absorption_Homo sapiens_hsa04974	0.45534789
74	AMPK signaling pathway_Homo sapiens_hsa04152	0.43856837
75	Endocytosis_Homo sapiens_hsa04144	0.42607736
76	Metabolic pathways_Homo sapiens_hsa01100	0.41653880
77	Salivary secretion_Homo sapiens_hsa04970	0.41458290
78	Gastric acid secretion_Homo sapiens_hsa04971	0.37816825
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36326303
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34845437
81	Taste transduction_Homo sapiens_hsa04742	0.34784443
82	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.31980762
83	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.30764970
84	VEGF signaling pathway_Homo sapiens_hsa04370	0.30071182
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.26542103
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.24445881
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.24417576
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.21284512
89	Alcoholism_Homo sapiens_hsa05034	0.19959600
90	Circadian entrainment_Homo sapiens_hsa04713	0.19340696
91	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.16227004
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.15413941
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.14129717
94	Cocaine addiction_Homo sapiens_hsa05030	0.13912875
95	Salmonella infection_Homo sapiens_hsa05132	0.10934315
96	Homologous recombination_Homo sapiens_hsa03440	0.10154684
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.09538417
98	Retinol metabolism_Homo sapiens_hsa00830	0.08851975
99	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.08803864
100	Viral carcinogenesis_Homo sapiens_hsa05203	0.08099670

ANKRD60

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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