ANKRD61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.89784920
2cilium or flagellum-dependent cell motility (GO:0001539)9.84557164
3motile cilium assembly (GO:0044458)9.69890376
4epithelial cilium movement (GO:0003351)9.64074042
5spermatid development (GO:0007286)9.44166441
6reproduction (GO:0000003)9.29941478
7regulation of cilium movement (GO:0003352)8.44864969
8cilium movement (GO:0003341)7.80684214
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39852710
10piRNA metabolic process (GO:0034587)7.27674505
11single fertilization (GO:0007338)7.25376972
12negative regulation of inclusion body assembly (GO:0090084)7.00148155
13synaptonemal complex organization (GO:0070193)6.95724958
14sperm capacitation (GO:0048240)6.90547470
15male meiosis (GO:0007140)6.89384334
16microtubule depolymerization (GO:0007019)6.78028876
17synaptonemal complex assembly (GO:0007130)6.75687001
18spermatogenesis (GO:0007283)6.46957099
19male gamete generation (GO:0048232)6.44574499
20organic cation transport (GO:0015695)6.20904072
21fertilization (GO:0009566)6.15471113
22gamete generation (GO:0007276)5.92360106
23nuclear pore organization (GO:0006999)5.87973826
24protoporphyrinogen IX metabolic process (GO:0046501)5.69500286
25regulation of RNA export from nucleus (GO:0046831)5.66925107
26regulation of inclusion body assembly (GO:0090083)5.65318463
27calcium ion-dependent exocytosis (GO:0017156)5.37138959
28regulation of nucleobase-containing compound transport (GO:0032239)5.27183530
29germ cell development (GO:0007281)5.26523502
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.26518340
31ventricular system development (GO:0021591)5.05305048
32chromosome condensation (GO:0030261)5.02423028
33pore complex assembly (GO:0046931)4.91260341
34cell recognition (GO:0008037)4.90105463
35male meiosis I (GO:0007141)4.83564267
36regulation of microtubule-based movement (GO:0060632)4.83114687
37DNA packaging (GO:0006323)4.78071003
38chromosome organization involved in meiosis (GO:0070192)4.74744740
39multicellular organismal reproductive process (GO:0048609)4.66473664
40sister chromatid segregation (GO:0000819)4.62017901
41mitotic chromosome condensation (GO:0007076)4.50511357
42DNA methylation involved in gamete generation (GO:0043046)4.50290946
43embryonic process involved in female pregnancy (GO:0060136)4.48749294
44spermatid nucleus differentiation (GO:0007289)4.48170074
45glycerol ether metabolic process (GO:0006662)4.47906689
46mitotic sister chromatid segregation (GO:0000070)4.45308407
47left/right pattern formation (GO:0060972)4.38805199
48seminiferous tubule development (GO:0072520)4.36481273
49DNA unwinding involved in DNA replication (GO:0006268)4.33896182
50meiotic nuclear division (GO:0007126)4.16314270
51microtubule severing (GO:0051013)4.15349939
52DNA topological change (GO:0006265)4.12776820
53iron ion import (GO:0097286)4.11816125
54ether metabolic process (GO:0018904)4.11110781
55regulation of histone H3-K27 methylation (GO:0061085)4.10471693
56regulation of sister chromatid cohesion (GO:0007063)4.07821658
57mitotic nuclear envelope disassembly (GO:0007077)4.03114703
58nuclear envelope disassembly (GO:0051081)3.99419997
59membrane disassembly (GO:0030397)3.99419997
60genitalia morphogenesis (GO:0035112)3.97210224
61chaperone-mediated protein complex assembly (GO:0051131)3.96113225
62meiosis I (GO:0007127)3.91481690
63protoporphyrinogen IX biosynthetic process (GO:0006782)3.90310742
64erythrocyte maturation (GO:0043249)3.86939261
65meiotic chromosome segregation (GO:0045132)3.84368988
66sexual reproduction (GO:0019953)3.78203754
67monoubiquitinated protein deubiquitination (GO:0035520)3.72281916
68multicellular organismal development (GO:0007275)3.71049674
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.69147732
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.69147732
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.69147732
72protein localization to chromosome, centromeric region (GO:0071459)3.62118175
73erythrocyte development (GO:0048821)3.56593315
74mitotic sister chromatid cohesion (GO:0007064)3.54754045
75protein localization to kinetochore (GO:0034501)3.53196477
76microtubule polymerization or depolymerization (GO:0031109)3.47053322
77meiotic cell cycle (GO:0051321)3.45244756
78oxygen transport (GO:0015671)3.44190806
79protein K11-linked deubiquitination (GO:0035871)3.43815386
80definitive hemopoiesis (GO:0060216)3.41299868
81porphyrin-containing compound biosynthetic process (GO:0006779)3.39185853
82DNA duplex unwinding (GO:0032508)3.39098198
83negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.35145410
84regulation of spindle checkpoint (GO:0090231)3.33163145
85positive regulation of chromosome segregation (GO:0051984)3.31507599
86negative regulation of cell cycle G2/M phase transition (GO:1902750)3.30470862
87single strand break repair (GO:0000012)3.28708109
88sphingosine metabolic process (GO:0006670)3.26687589
89negative regulation of histone methylation (GO:0031061)3.26465991
90DNA geometric change (GO:0032392)3.25625152
91interferon-gamma secretion (GO:0072643)3.23772294
92regulation of translational fidelity (GO:0006450)3.23117792
93DNA replication initiation (GO:0006270)3.21322537
94gas transport (GO:0015669)3.20384326
95protein polyglutamylation (GO:0018095)3.19825332
96nucleus organization (GO:0006997)3.19358655
97positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.18300035
98mitotic recombination (GO:0006312)3.15681223
99telomere maintenance via recombination (GO:0000722)3.08817320
100glucocorticoid receptor signaling pathway (GO:0042921)3.08018792
101DNA synthesis involved in DNA repair (GO:0000731)3.07837421
102nuclear envelope organization (GO:0006998)3.06745881
103DNA conformation change (GO:0071103)3.05966471
104regulation of centrosome duplication (GO:0010824)3.05649141
105V(D)J recombination (GO:0033151)3.04177180
106histone H3-K4 trimethylation (GO:0080182)3.00976148
107histone H3-K4 methylation (GO:0051568)2.99907772
108COPI coating of Golgi vesicle (GO:0048205)2.99518220
109Golgi transport vesicle coating (GO:0048200)2.99518220
110stress granule assembly (GO:0034063)2.99190361
111protein refolding (GO:0042026)2.98678253
112protein localization to cilium (GO:0061512)2.98335797
113polyol catabolic process (GO:0046174)2.97224089
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96883612
115amino-acid betaine transport (GO:0015838)2.96437359
116carnitine transport (GO:0015879)2.96437359
117COPII vesicle coating (GO:0048208)2.96116727
118protein export from nucleus (GO:0006611)2.95589488
119gene silencing by RNA (GO:0031047)2.95139590
120protein K48-linked deubiquitination (GO:0071108)2.93995548
121regulation of spindle organization (GO:0090224)2.92942902
122synapsis (GO:0007129)2.92904529
123regulation of mitotic spindle organization (GO:0060236)2.92136673
124spliceosomal tri-snRNP complex assembly (GO:0000244)2.91974703
125glycolytic process (GO:0006096)2.91687091
126dosage compensation (GO:0007549)2.91375597
127histone phosphorylation (GO:0016572)2.91011503
128cytoplasmic mRNA processing body assembly (GO:0033962)2.90745910
129N-terminal protein amino acid acetylation (GO:0006474)2.90368396
130regulation of translational termination (GO:0006449)2.90029722
131corticosteroid receptor signaling pathway (GO:0031958)2.88385971
132chromosome segregation (GO:0007059)2.87077679
133regulation of centrosome cycle (GO:0046605)2.86374503
134cilium organization (GO:0044782)2.83843357
135peptidyl-lysine trimethylation (GO:0018023)2.83236283
136meiotic cell cycle process (GO:1903046)2.81226464
137negative regulation of organelle assembly (GO:1902116)2.80798424
138RNA stabilization (GO:0043489)2.80663258
139mRNA stabilization (GO:0048255)2.80663258
140carnitine transmembrane transport (GO:1902603)2.80079799
141alternative mRNA splicing, via spliceosome (GO:0000380)2.79816024
142proline biosynthetic process (GO:0006561)2.79754154
143alditol metabolic process (GO:0019400)2.78757695
144regulation of DNA damage checkpoint (GO:2000001)2.78600444
145nuclear pore complex assembly (GO:0051292)2.77947148
146regulation of histone methylation (GO:0031060)2.77855344
147peptidyl-lysine methylation (GO:0018022)2.76652561
148porphyrin-containing compound metabolic process (GO:0006778)2.74726973
149regulation of histone H3-K4 methylation (GO:0051569)2.73832887
150myeloid cell development (GO:0061515)2.73525463
151mRNA transport (GO:0051028)2.73408079
152cilium assembly (GO:0042384)2.73267728
153pre-miRNA processing (GO:0031054)2.72390038
154microtubule-based movement (GO:0007018)2.71242221
155tetrapyrrole biosynthetic process (GO:0033014)2.68895856
156RNA localization (GO:0006403)2.68710122
157interkinetic nuclear migration (GO:0022027)2.68120334
158nodal signaling pathway (GO:0038092)2.67401455
159inner cell mass cell proliferation (GO:0001833)2.66948044
160RNA destabilization (GO:0050779)2.66352015
161negative regulation of skeletal muscle tissue development (GO:0048642)2.63883718
162cellular component assembly involved in morphogenesis (GO:0010927)2.62843791
163diol metabolic process (GO:0034311)2.61697103
164positive regulation of developmental pigmentation (GO:0048087)2.60689658
165protein localization to chromosome (GO:0034502)2.60065908
166peptidyl-lysine dimethylation (GO:0018027)2.59969531
167regulation of NFAT protein import into nucleus (GO:0051532)2.59814965
168sequestering of actin monomers (GO:0042989)2.59724435
169histone lysine demethylation (GO:0070076)2.58012534
170gene silencing (GO:0016458)2.57639468
171peptidyl-glutamic acid modification (GO:0018200)2.57277138
172nucleoside diphosphate phosphorylation (GO:0006165)2.56956690
173regulation of histone H3-K9 methylation (GO:0051570)2.56912672
174centriole assembly (GO:0098534)2.55708346
175regulation of cilium assembly (GO:1902017)2.52266812
176lactate metabolic process (GO:0006089)2.51599327
177cilium morphogenesis (GO:0060271)2.49699683
178regulation of response to osmotic stress (GO:0047484)2.49414153
179regulation of centriole replication (GO:0046599)2.49186730
180intraciliary transport (GO:0042073)2.47569026
181sperm motility (GO:0030317)13.5711843
182fusion of sperm to egg plasma membrane (GO:0007342)13.3422207
183cell wall macromolecule catabolic process (GO:0016998)12.1701013
184cell wall macromolecule metabolic process (GO:0044036)12.1701013
185acrosome reaction (GO:0007340)11.9517001
186sperm-egg recognition (GO:0035036)11.2416067
187acrosome assembly (GO:0001675)11.0427542
188multicellular organism reproduction (GO:0032504)10.8758082
189cell-cell recognition (GO:0009988)10.2083197
190binding of sperm to zona pellucida (GO:0007339)10.1169279
191plasma membrane fusion (GO:0045026)10.1118458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.82728950
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.47130607
3EZH2_22144423_ChIP-Seq_EOC_Human3.97284626
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.93727262
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88775321
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.64597570
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.52075275
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.36948650
9GATA1_22025678_ChIP-Seq_K562_Human3.19382326
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.97339677
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.91264134
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66780115
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59874492
14GATA1_19941826_ChIP-Seq_K562_Human2.54916827
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.53006302
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48095212
17MYC_22102868_ChIP-Seq_BL_Human2.42492805
18AR_21909140_ChIP-Seq_LNCAP_Human2.40612628
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.35547072
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27694866
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.21011274
22GATA1_26923725_Chip-Seq_HPCs_Mouse2.17827328
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09694588
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09675938
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02345645
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.00776372
27E2F7_22180533_ChIP-Seq_HELA_Human11.0910947
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.91989058
29VDR_22108803_ChIP-Seq_LS180_Human1.88297833
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84383321
31SCL_19346495_ChIP-Seq_HPC-7_Human1.79495637
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79273973
33GATA2_19941826_ChIP-Seq_K562_Human1.75013874
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72347281
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.71964791
36ZNF274_21170338_ChIP-Seq_K562_Hela1.70074656
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69428889
38NCOR1_26117541_ChIP-Seq_K562_Human1.67869272
39STAT1_17558387_ChIP-Seq_HELA_Human1.67819082
40TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65787848
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.61925138
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61749589
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60712006
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54698124
45GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53860872
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52742387
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52453945
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52057656
49TFEB_21752829_ChIP-Seq_HELA_Human1.51900044
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51829051
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51811451
52CIITA_25753668_ChIP-Seq_RAJI_Human1.50640995
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.50353224
54KDM2B_26808549_Chip-Seq_REH_Human1.49685736
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49537952
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49419651
57DCP1A_22483619_ChIP-Seq_HELA_Human1.48942176
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43792310
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40492967
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.37746903
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.37530411
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.35156093
63FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34585762
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32595221
65CBP_20019798_ChIP-Seq_JUKART_Human1.31091201
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31091201
67GF1_26923725_Chip-Seq_HPCs_Mouse1.30508053
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30315130
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29793468
70GATA3_21867929_ChIP-Seq_CD8_Mouse1.29086698
71KDM5A_27292631_Chip-Seq_BREAST_Human1.28207623
72CHD1_26751641_Chip-Seq_LNCaP_Human1.27396505
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.27037442
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26797313
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25891682
76P53_21459846_ChIP-Seq_SAOS-2_Human1.25589613
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.25412417
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24938323
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24694701
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23609780
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22039400
82TCF7_22412390_ChIP-Seq_EML_Mouse1.21257265
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20304184
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18540614
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18359101
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18059403
87RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17090800
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17031039
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15429637
90SPI1_26923725_Chip-Seq_HPCs_Mouse1.15102211
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.14879630
92CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14778310
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.14554232
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14176983
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12784187
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12784187
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12448230
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.11119613
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10778345
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10127684
101REST_21632747_ChIP-Seq_MESCs_Mouse1.08420863
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08225819
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07480845
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07308744
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07169107
106EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06810494
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06495634
108RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05880848
109SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05675628
110CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04979226
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04502246
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.04401031
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04371276
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04173714
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04102533
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03107448
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.02568589
118CLOCK_20551151_ChIP-Seq_293T_Human1.01917073
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01814084
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01604103
121AR_21572438_ChIP-Seq_LNCaP_Human1.01534983
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00882201
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00338756
124RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00082970
125NFYB_21822215_ChIP-Seq_K562_Human1.00011420
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00006341
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.99912739
128GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99838850
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99314697
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98809023
131ELK1_19687146_ChIP-ChIP_HELA_Human0.98102814
132GF1B_26923725_Chip-Seq_HPCs_Mouse0.97957547
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97726876
134SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97717475
135MYB_26560356_Chip-Seq_TH1_Human0.97623799
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96899292
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.96130580
138OCT4_18555785_Chip-Seq_ESCs_Mouse0.96088195
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95508877
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95508877
141OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94527213
142CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94504641
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94154358
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.94136620
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94092154
146MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94026086
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93663750
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93291986
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.93283437
150ERG_20517297_ChIP-Seq_VCAP_Human0.93074919
151ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92898561
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92300324
153E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92220641
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.91380166
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91137032
156* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90663524
157FOXP3_21729870_ChIP-Seq_TREG_Human0.90620922
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90588817
159ESET_19884257_ChIP-Seq_ESCs_Mouse0.89863958
160TBL1_22424771_ChIP-Seq_293T_Human0.89815464
161SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89395646
162P53_22387025_ChIP-Seq_ESCs_Mouse0.89256610
163HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88999881
164XRN2_22483619_ChIP-Seq_HELA_Human0.88890028
165RARA_24833708_ChIP-Seq_LIVER_Mouse0.88838515
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.88733112
167KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88575262
168GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87947711
169SOX9_26525672_Chip-Seq_HEART_Mouse0.87783222
170RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86848846
171SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86832750
172MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85890020
173GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85591036
174CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85474959
175NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84841452
176SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84808401
177DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84389254
178SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84207262
179SOX17_20123909_ChIP-Seq_XEN_Mouse0.84028119
180KLF4_18555785_Chip-Seq_ESCs_Mouse0.83713584
181EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83682758
182GATA1_19941827_ChIP-Seq_MEL_Mouse0.83676894
183ETV1_20927104_ChIP-Seq_GIST48_Human0.83438008
184OCT1_27270436_Chip-Seq_PROSTATE_Human0.83340372
185VDR_21846776_ChIP-Seq_THP-1_Human0.82907062
186MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82859793
187TP63_19390658_ChIP-ChIP_HaCaT_Human0.82773913
188GATA6_25053715_ChIP-Seq_YYC3_Human0.82218743
189ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80678098
190PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80477802
191ATF3_27146783_Chip-Seq_COLON_Human0.80405628
192NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80281342
193TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80273482
194P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79415603
195ZNF263_19887448_ChIP-Seq_K562_Human0.76736707
196SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76413694
197TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76375947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.95474083
2MP0001929_abnormal_gametogenesis5.42684226
3MP0008877_abnormal_DNA_methylation4.33710787
4MP0004147_increased_porphyrin_level4.18231750
5MP0003890_abnormal_embryonic-extraembry3.53300592
6MP0003705_abnormal_hypodermis_morpholog3.41248571
7MP0002210_abnormal_sex_determination3.33875542
8MP0002161_abnormal_fertility/fecundity3.26061028
9MP0001145_abnormal_male_reproductive2.80362812
10MP0005670_abnormal_white_adipose2.75492354
11MP0005076_abnormal_cell_differentiation2.74752825
12MP0000653_abnormal_sex_gland2.41070361
13MP0005083_abnormal_biliary_tract2.40330544
14MP0002009_preneoplasia2.40212124
15MP0010352_gastrointestinal_tract_polyps2.34910644
16MP0002653_abnormal_ependyma_morphology2.25794007
17MP0004957_abnormal_blastocyst_morpholog2.20830288
18MP0002396_abnormal_hematopoietic_system2.18845281
19MP0004185_abnormal_adipocyte_glucose2.16814359
20MP0003693_abnormal_embryo_hatching2.05724963
21MP0005171_absent_coat_pigmentation2.03622600
22MP0005410_abnormal_fertilization15.9507745
23MP0005451_abnormal_body_composition1.90311931
24MP0005408_hypopigmentation1.70659498
25MP0008932_abnormal_embryonic_tissue1.70466281
26MP0008007_abnormal_cellular_replicative1.68143812
27MP0003566_abnormal_cell_adhesion1.55288673
28MP0002160_abnormal_reproductive_system1.54567871
29MP0001697_abnormal_embryo_size1.54552748
30MP0002086_abnormal_extraembryonic_tissu1.53723869
31MP0000350_abnormal_cell_proliferation1.52905120
32MP0003943_abnormal_hepatobiliary_system1.52721344
33MP0000569_abnormal_digit_pigmentation1.48108166
34MP0004381_abnormal_hair_follicle1.43253046
35MP0008260_abnormal_autophagy1.42651029
36MP0006054_spinal_hemorrhage1.33425197
37MP0000372_irregular_coat_pigmentation1.31761199
38MP0002080_prenatal_lethality1.30475872
39MP0004233_abnormal_muscle_weight1.26979269
40MP0003221_abnormal_cardiomyocyte_apopto1.25306647
41MP0005621_abnormal_cell_physiology1.24887399
42MP0001661_extended_life_span1.24703917
43MP0005075_abnormal_melanosome_morpholog1.19586363
44MP0002877_abnormal_melanocyte_morpholog1.13794557
45MP0003646_muscle_fatigue1.13530273
46MP0003136_yellow_coat_color1.09126114
47MP0001915_intracranial_hemorrhage1.09125954
48MP0001765_abnormal_ion_homeostasis1.07993753
49MP0005623_abnormal_meninges_morphology1.07866383
50MP0002166_altered_tumor_susceptibility1.06439133
51MP0002085_abnormal_embryonic_tissue1.06387369
52MP0009697_abnormal_copulation1.02404655
53MP0010094_abnormal_chromosome_stability1.01408519
54MP0004197_abnormal_fetal_growth/weight/1.01029304
55MP0005384_cellular_phenotype0.99478834
56MP0002837_dystrophic_cardiac_calcinosis0.97215154
57MP0002282_abnormal_trachea_morphology0.96921524
58MP0008058_abnormal_DNA_repair0.94549377
59MP0005666_abnormal_adipose_tissue0.94437668
60MP0003115_abnormal_respiratory_system0.90923088
61MP0004264_abnormal_extraembryonic_tissu0.90802159
62MP0008004_abnormal_stomach_pH0.88599404
63MP0003763_abnormal_thymus_physiology0.88560306
64MP0002019_abnormal_tumor_incidence0.88303529
65MP0008995_early_reproductive_senescence0.86642510
66MP0003111_abnormal_nucleus_morphology0.85794712
67MP0005647_abnormal_sex_gland0.84810301
68MP0000428_abnormal_craniofacial_morphol0.80857697
69MP0009278_abnormal_bone_marrow0.79908179
70MP0005389_reproductive_system_phenotype0.79800738
71MP0009931_abnormal_skin_appearance0.79155327
72MP0002075_abnormal_coat/hair_pigmentati0.78363519
73MP0005377_hearing/vestibular/ear_phenot0.77567307
74MP0003878_abnormal_ear_physiology0.77567307
75MP0009703_decreased_birth_body0.77425622
76MP0002925_abnormal_cardiovascular_devel0.77408383
77MP0002971_abnormal_brown_adipose0.77012825
78MP0001545_abnormal_hematopoietic_system0.75176123
79MP0005397_hematopoietic_system_phenotyp0.75176123
80MP0000749_muscle_degeneration0.73816204
81MP0003091_abnormal_cell_migration0.73411527
82MP0003303_peritoneal_inflammation0.73260648
83MP0004808_abnormal_hematopoietic_stem0.72280198
84MP0010630_abnormal_cardiac_muscle0.72227460
85MP0009046_muscle_twitch0.71566919
86MP0003045_fibrosis0.71299524
87MP0000490_abnormal_crypts_of0.68546998
88MP0008770_decreased_survivor_rate0.68355254
89MP0002928_abnormal_bile_duct0.68311666
90MP0002095_abnormal_skin_pigmentation0.66905220
91MP0005187_abnormal_penis_morphology0.66037713
92MP0005310_abnormal_salivary_gland0.65849733
93MP0003453_abnormal_keratinocyte_physiol0.65548124
94MP0003935_abnormal_craniofacial_develop0.63438860
95MP0000377_abnormal_hair_follicle0.62008514
96MP0000266_abnormal_heart_morphology0.60788437
97MP0006035_abnormal_mitochondrial_morpho0.60710520
98MP0001186_pigmentation_phenotype0.58534773
99MP0000609_abnormal_liver_physiology0.57936897
100MP0008961_abnormal_basal_metabolism0.57934044
101MP0000598_abnormal_liver_morphology0.57425247
102MP0002405_respiratory_system_inflammati0.55129467
103MP0003300_gastrointestinal_ulcer0.54864728
104MP0008057_abnormal_DNA_replication0.54387061
105MP0001324_abnormal_eye_pigmentation0.53658908
106MP0000358_abnormal_cell_content/0.49915225
107MP0005375_adipose_tissue_phenotype0.49847633
108MP0005636_abnormal_mineral_homeostasis0.49823286
109MP0000015_abnormal_ear_pigmentation0.48128353
110MP0003699_abnormal_female_reproductive0.45997773
111MP0009115_abnormal_fat_cell0.45597489
112MP0001764_abnormal_homeostasis0.43962437
113MP0010307_abnormal_tumor_latency0.43661492
114MP0002736_abnormal_nociception_after0.43381122
115MP0003787_abnormal_imprinting0.43305853
116MP0001984_abnormal_olfaction0.42636708
117MP0002398_abnormal_bone_marrow0.42510812
118MP0003656_abnormal_erythrocyte_physiolo0.42289350
119MP0005174_abnormal_tail_pigmentation0.41967403
120MP0002234_abnormal_pharynx_morphology0.41799345
121MP0002269_muscular_atrophy0.41212951
122MP0000703_abnormal_thymus_morphology0.38066597
123MP0003786_premature_aging0.36916210
124MP0003950_abnormal_plasma_membrane0.36166631
125MP0002970_abnormal_white_adipose0.36119847
126MP0001119_abnormal_female_reproductive0.35829792
127MP0001873_stomach_inflammation0.34766798
128MP0000689_abnormal_spleen_morphology0.34492930
129MP0000313_abnormal_cell_death0.33857540
130MP0003077_abnormal_cell_cycle0.33176202
131MP0002723_abnormal_immune_serum0.33094859
132MP0001730_embryonic_growth_arrest0.32183421
133MP0005464_abnormal_platelet_physiology0.32070388
134MP0003011_delayed_dark_adaptation0.32010490
135MP0000604_amyloidosis0.30317121
136MP0001800_abnormal_humoral_immune0.29474318
137MP0003959_abnormal_lean_body0.29232423
138MP0003866_abnormal_defecation0.28755560
139MP0001440_abnormal_grooming_behavior0.28574852
140MP0000371_diluted_coat_color0.28117128
141MP0005380_embryogenesis_phenotype0.26886475
142MP0001672_abnormal_embryogenesis/_devel0.26886475
143MP0002722_abnormal_immune_system0.26067615
144MP0000716_abnormal_immune_system0.25530699
145MP0003948_abnormal_gas_homeostasis0.25148363
146MP0003984_embryonic_growth_retardation0.24769030
147MP0002452_abnormal_antigen_presenting0.24411337
148MP0004811_abnormal_neuron_physiology0.24214453
149MP0001293_anophthalmia0.24111363
150MP0000685_abnormal_immune_system0.23324642
151MP0002420_abnormal_adaptive_immunity0.22681031
152MP0002169_no_abnormal_phenotype0.22575594
153MP0002088_abnormal_embryonic_growth/wei0.22535156
154MP0002429_abnormal_blood_cell0.22509401
155MP0002873_normal_phenotype0.22186218
156MP0002084_abnormal_developmental_patter0.21715368
157MP0001986_abnormal_taste_sensitivity0.21704580
158MP0001819_abnormal_immune_cell0.21385907
159MP0002168_other_aberrant_phenotype0.20760670
160MP0003633_abnormal_nervous_system0.20715551
161MP0003252_abnormal_bile_duct0.20542738
162MP0004019_abnormal_vitamin_homeostasis0.19151664
163MP0005423_abnormal_somatic_nervous0.18979639

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.11291657
2Abnormal respiratory epithelium morphology (HP:0012253)9.11291657
3Abnormal respiratory motile cilium physiology (HP:0012261)8.95148846
4Rhinitis (HP:0012384)7.45093475
5Chronic bronchitis (HP:0004469)6.98539472
6Abnormal ciliary motility (HP:0012262)6.95563974
7Infertility (HP:0000789)6.68587257
8Nasal polyposis (HP:0100582)6.53490923
9Abnormality of the nasal mucosa (HP:0000433)5.30962233
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.85677850
11Bronchitis (HP:0012387)4.74079504
12Chromsome breakage (HP:0040012)4.52770199
13Bronchiectasis (HP:0002110)4.47751156
14Acanthocytosis (HP:0001927)4.47673762
15Male infertility (HP:0003251)4.46439770
16Abnormality of the heme biosynthetic pathway (HP:0010472)4.07877057
17Abnormality of the fingertips (HP:0001211)3.97078549
18Nephronophthisis (HP:0000090)3.87824029
19Recurrent sinusitis (HP:0011108)3.67095109
20Abnormal spermatogenesis (HP:0008669)3.62510348
21Recurrent otitis media (HP:0000403)3.55524171
22Overlapping toe (HP:0001845)3.30004200
23Recurrent bronchitis (HP:0002837)3.24439525
24Nephroblastoma (Wilms tumor) (HP:0002667)2.99527944
25Impulsivity (HP:0100710)2.95526135
26Abnormality of the renal medulla (HP:0100957)2.87906936
27Acute myeloid leukemia (HP:0004808)2.85715158
28Volvulus (HP:0002580)2.83602268
29Ileus (HP:0002595)2.79577481
30Embryonal renal neoplasm (HP:0011794)2.73102812
31Abnormality of reticulocytes (HP:0004312)2.64753851
32Sandal gap (HP:0001852)2.63267838
33Sparse lateral eyebrow (HP:0005338)2.53726129
34Ankyloglossia (HP:0010296)2.51076336
35Cholelithiasis (HP:0001081)2.48003604
36Polycythemia (HP:0001901)2.45812069
37Hypopigmentation of the fundus (HP:0007894)2.44768686
38Orthostatic hypotension (HP:0001278)2.40774931
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.39007192
40Cholecystitis (HP:0001082)2.38510787
41Abnormal gallbladder physiology (HP:0012438)2.38510787
42Long eyelashes (HP:0000527)2.38126278
43Lower limb hyperreflexia (HP:0002395)2.37412460
44Insidious onset (HP:0003587)2.33638331
45Termporal pattern (HP:0011008)2.33638331
46Tubulointerstitial nephritis (HP:0001970)2.32762689
47Abnormality of midbrain morphology (HP:0002418)2.30590175
48Molar tooth sign on MRI (HP:0002419)2.30590175
49Heterotopia (HP:0002282)2.28856692
50Poikiloderma (HP:0001029)2.24525610
51Birth length less than 3rd percentile (HP:0003561)2.24240873
52Gonadotropin excess (HP:0000837)2.22252133
53Tubular atrophy (HP:0000092)2.19113024
54Abnormality of oral frenula (HP:0000190)2.18345813
55Increased nuchal translucency (HP:0010880)2.15201985
56Chin dimple (HP:0010751)2.14872761
57Dysmetric saccades (HP:0000641)2.11370883
58Abnormal foot bone ossification (HP:0010675)2.10101674
59Asymmetry of the thorax (HP:0001555)2.09470733
60Azoospermia (HP:0000027)2.08469563
61Small epiphyses (HP:0010585)2.05926863
62Hyperbilirubinemia (HP:0002904)2.04807612
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03807873
64Abnormal gallbladder morphology (HP:0012437)2.03483691
65Tubulointerstitial abnormality (HP:0001969)2.02666028
66Malignant gastrointestinal tract tumors (HP:0006749)2.02056132
67Gastrointestinal carcinoma (HP:0002672)2.02056132
68Cafe-au-lait spot (HP:0000957)2.01979535
69Leiomyosarcoma (HP:0100243)2.01968744
70Uterine leiomyosarcoma (HP:0002891)2.01968744
71Medial flaring of the eyebrow (HP:0010747)2.00807181
72Dyschromatopsia (HP:0007641)2.00650885
73Papillary thyroid carcinoma (HP:0002895)2.00412573
74Dynein arm defect of respiratory motile cilia (HP:0012255)13.3761095
75Absent/shortened dynein arms (HP:0200106)13.3761095
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7209320
77Abnormality of DNA repair (HP:0003254)1.96924668
78Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95862499
79Choroideremia (HP:0001139)1.95360718
80Depressed nasal tip (HP:0000437)1.94759800
81Germ cell neoplasia (HP:0100728)1.94050898
82Long clavicles (HP:0000890)1.91373611
83Renal cell carcinoma (HP:0005584)1.90611895
84Spastic tetraparesis (HP:0001285)1.89905985
85Embryonal neoplasm (HP:0002898)1.87980755
86Abnormal lung lobation (HP:0002101)1.84973135
87Hemorrhage of the eye (HP:0011885)1.84547829
88Vertebral arch anomaly (HP:0008438)1.84394647
89Entropion (HP:0000621)1.83268113
90Ulnar bowing (HP:0003031)1.80823405
91Ependymoma (HP:0002888)1.80359965
92Anal stenosis (HP:0002025)1.79788814
93Self-mutilation (HP:0000742)1.78551995
94Myelodysplasia (HP:0002863)1.78121089
95Esophageal varix (HP:0002040)1.78074626
96Osteomalacia (HP:0002749)1.76070086
97Deep philtrum (HP:0002002)1.75521588
98Breech presentation (HP:0001623)1.75276256
99Subacute progressive viral hepatitis (HP:0006572)1.74727746
100Chronic sinusitis (HP:0011109)1.74570777
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73802767
102Short chin (HP:0000331)1.70582865
103Central scotoma (HP:0000603)1.69975434
104Postaxial foot polydactyly (HP:0001830)1.68827489
105Absent frontal sinuses (HP:0002688)1.68468155
106Abnormality of the gallbladder (HP:0005264)1.67695799
107Duplicated collecting system (HP:0000081)1.67160828
108Viral hepatitis (HP:0006562)1.66885760
109Rectal prolapse (HP:0002035)1.65785264
110Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65315787
111Pelvic girdle muscle weakness (HP:0003749)1.64363427
112Neoplasm of the small intestine (HP:0100833)1.63449274
113Shoulder girdle muscle weakness (HP:0003547)1.63268474
114Transitional cell carcinoma of the bladder (HP:0006740)1.62869852
115Bile duct proliferation (HP:0001408)1.62365228
116Abnormal biliary tract physiology (HP:0012439)1.62365228
117Tubulointerstitial fibrosis (HP:0005576)1.62358670
118Deformed sella turcica (HP:0002681)1.61398101
119Testicular neoplasm (HP:0010788)1.60879734
120Bladder neoplasm (HP:0009725)1.60339066
121Bladder carcinoma (HP:0002862)1.60339066
122Insomnia (HP:0100785)1.59668083
123Aplastic anemia (HP:0001915)1.58981135
124Curly hair (HP:0002212)1.58500519
125Renal dysplasia (HP:0000110)1.58175889
126Intestinal malrotation (HP:0002566)1.57940553
127Broad face (HP:0000283)1.57122481
128Hammertoe (HP:0001765)1.57045169
129Abnormality of chromosome stability (HP:0003220)1.56961380
130Obsessive-compulsive behavior (HP:0000722)1.56526906
131Abnormal ventriculo-arterial connection (HP:0011563)1.55696155
132Transposition of the great arteries (HP:0001669)1.55696155
133Abnormal connection of the cardiac segments (HP:0011545)1.55696155
134Diaphragmatic weakness (HP:0009113)1.55037768
135Cortical dysplasia (HP:0002539)1.54885559
136Retinal atrophy (HP:0001105)1.54805381
137Disproportionate tall stature (HP:0001519)1.54768879
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54426695
139Absent epiphyses (HP:0010577)1.54426695
140Relative macrocephaly (HP:0004482)1.54042827
141Congenital hepatic fibrosis (HP:0002612)1.53942771
142Decreased central vision (HP:0007663)1.53644248
143Abnormality of the preputium (HP:0100587)1.53418836
144Abnormality of chromosome segregation (HP:0002916)1.53047118
145Abnormality of the lower motor neuron (HP:0002366)1.52357527
146Short ribs (HP:0000773)1.49897922
147J-shaped sella turcica (HP:0002680)1.49724013
148Stage 5 chronic kidney disease (HP:0003774)1.49353630
149Loss of speech (HP:0002371)1.48516274
150Hemiparesis (HP:0001269)1.48380533
151Congenital malformation of the right heart (HP:0011723)1.46862248
152Double outlet right ventricle (HP:0001719)1.46862248
153Bell-shaped thorax (HP:0001591)1.40319811
154Abnormality of ocular smooth pursuit (HP:0000617)1.40130980
155Polydipsia (HP:0001959)1.39237353
156Abnormal drinking behavior (HP:0030082)1.39237353
157Easy fatigability (HP:0003388)1.38349126
158Oculomotor apraxia (HP:0000657)1.38130694
159Abnormality of the renal cortex (HP:0011035)1.37461057
160Abnormality of renal excretion (HP:0011036)1.35037824
161Fibular hypoplasia (HP:0003038)1.34688158
162Abnormality of the dental root (HP:0006486)1.31425382
163Taurodontia (HP:0000679)1.31425382
164Abnormality of permanent molar morphology (HP:0011071)1.31425382
165Flattened epiphyses (HP:0003071)1.30381745
166Truncal obesity (HP:0001956)1.29872653
167Postaxial hand polydactyly (HP:0001162)1.28695924
168Asymmetric septal hypertrophy (HP:0001670)1.28670441
169Colitis (HP:0002583)1.28613008
170Aplasia/Hypoplasia of the lens (HP:0008063)1.26623514
171Decreased electroretinogram (ERG) amplitude (HP:0000654)1.26018818
172Short femoral neck (HP:0100864)1.25311076
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22495456
174Short thorax (HP:0010306)1.22262774
175Abnormality of molar (HP:0011077)1.21499131
176Abnormality of molar morphology (HP:0011070)1.21499131
177Poikilocytosis (HP:0004447)1.20719636
178Impaired proprioception (HP:0010831)1.20492165
179Cystic liver disease (HP:0006706)1.19052183
180High pitched voice (HP:0001620)1.18139579
181Abnormality of the dental pulp (HP:0006479)1.17819096
182Facial cleft (HP:0002006)1.17348561
183Abnormality of saccadic eye movements (HP:0000570)1.17184955
184Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.16920989
185Vascular calcification (HP:0004934)1.15939470
186Sensory axonal neuropathy (HP:0003390)1.15675313
187Reticulocytosis (HP:0001923)1.14732529
188Abnormality of the sella turcica (HP:0002679)1.14378336
189Impaired smooth pursuit (HP:0007772)1.14012653
190Hypercholesterolemia (HP:0003124)1.13852269
191Chronic hepatic failure (HP:0100626)1.13109504
192Inflammation of the large intestine (HP:0002037)1.12851521
193Neurofibrillary tangles (HP:0002185)1.12313064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.97770282
2PDK37.97770282
3TESK15.86378531
4PRKD35.12377992
5PDK25.03661631
6ICK4.49972490
7MAP3K124.37653354
8LATS14.33411400
9BRSK23.02651553
10EIF2AK32.24666223
11PTK2B2.15506297
12LATS22.12273199
13WNK42.08270776
14TRIB32.03594620
15BRD42.01071643
16EEF2K1.87474932
17PRPF4B1.86803701
18PNCK1.80421156
19STK391.74948716
20CAMK1D1.72009451
21NEK21.66202314
22MAP3K111.65891725
23STK381.61568767
24DYRK1B1.58186663
25BRSK11.47834063
26MAP3K21.44418888
27KSR11.41028629
28SCYL21.30276053
29ERBB41.21951466
30IRAK31.19334263
31NEK91.18563981
32KSR21.16671730
33PDK11.14146583
34RPS6KB21.05975006
35PBK1.04706826
36WNK11.04640866
37RIPK41.01836003
38WEE11.00496991
39MAP3K10.96147499
40BMPR20.92246377
41STK38L0.90241728
42CCNB10.86810224
43SIK10.84590216
44PASK0.84127706
45CDK120.82321011
46IRAK10.81754218
47CAMK1G0.80726101
48ACVR1B0.80273882
49PKN20.77898472
50MAP3K80.77841792
51STK30.75677516
52SMG10.75196668
53MAP2K20.74447597
54BMPR1B0.73145033
55PLK30.72093148
56FGFR40.70233355
57BUB10.69785361
58TYRO30.68355813
59CDK70.67698182
60PRKAA20.67314063
61MAP2K60.65995963
62BMX0.65508719
63CAMKK20.64352032
64PDPK10.63068759
65DYRK30.62997858
66CHEK20.62815647
67MAP3K140.61868503
68MAP2K10.61300402
69MARK20.59910402
70MAPK110.59023933
71RAF10.58439247
72MAP3K100.58163129
73CHEK10.57102997
74MAP3K60.56768143
75CDK30.56396962
76AKT30.55958571
77ZAP700.55549525
78PDGFRA0.55524004
79TNIK0.55199463
80CDC70.53686220
81MAPK150.51457354
82MET0.51109161
83SIK30.51036700
84RET0.50838004
85MAP4K10.50153910
86AURKB0.50129319
87SGK30.49550888
88ZAK0.48877789
89NEK10.48847014
90TTK0.48559709
91CDK80.48536842
92SRPK10.47689474
93STK100.45641937
94ATR0.44908994
95FGFR30.43647962
96MTOR0.42789220
97AKT10.39351983
98MAPKAPK50.37068621
99MAPK100.36862843
100TESK20.36398063
101TGFBR20.35355034
102BTK0.35257283
103SGK20.34169399
104GRK60.34055013
105ATM0.33758665
106FGR0.33455744
107MAP2K30.32890400
108TSSK60.32351156
109PLK20.31940281
110PAK10.29620659
111MAPKAPK30.29249237
112PRKCQ0.28286475
113PRKAA10.24958068
114PAK20.23775976
115CAMKK10.23502009
116MARK30.22619941
117PAK40.22055867
118RPS6KB10.21497425
119MAP3K40.21402240
120SIK20.21000885
121YES10.20075947
122CSF1R0.19794034
123NTRK20.18559810
124CDK150.18004061
125PIM10.17223802
126MAP3K50.16293154
127STK40.16156672
128NLK0.14822075
129IRAK20.14504917
130CDK180.14369617
131PRKCG0.13686150
132RPS6KA40.13304407
133EIF2AK10.13290456
134LMTK20.13278876
135CDK60.12409028
136CDK11A0.12110354
137ITK0.10920677
138CSK0.10812950
139EGFR0.10734103
140CDK40.10509174
141PLK10.10073875
142CSNK1D0.09907038
143CDK10.06860567
144GSK3B0.06406845
145CDK20.05753415
146PRKCZ0.05473150
147HCK0.05418472
148MST1R0.05152560
149SYK0.04774811
150TAOK10.04634514
151TYK20.04403704
152TRPM70.04342113
153PLK40.04067220
154PKN10.03593447
155TTN0.03515600
156STK110.03412474
157CLK10.03351830
158MAP2K40.03226371
159MAPK80.02692538
160CDK140.02339200
161LCK0.02036862
162PRKCB0.01310107
163MELK0.01244926

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.01909541
2Fatty acid biosynthesis_Homo sapiens_hsa000613.94540742
3Vitamin B6 metabolism_Homo sapiens_hsa007503.45088292
4Pyruvate metabolism_Homo sapiens_hsa006202.93226440
5Selenocompound metabolism_Homo sapiens_hsa004502.64146015
6Glucagon signaling pathway_Homo sapiens_hsa049222.56432435
7Cell cycle_Homo sapiens_hsa041102.56079527
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54157230
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.43102046
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.42929961
11Linoleic acid metabolism_Homo sapiens_hsa005912.35645973
12Non-small cell lung cancer_Homo sapiens_hsa052232.26313133
13Chronic myeloid leukemia_Homo sapiens_hsa052202.25320615
14Dorso-ventral axis formation_Homo sapiens_hsa043202.25070818
15Propanoate metabolism_Homo sapiens_hsa006402.23502150
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17064404
17DNA replication_Homo sapiens_hsa030302.15508023
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13376437
19Pancreatic cancer_Homo sapiens_hsa052122.11787991
20Acute myeloid leukemia_Homo sapiens_hsa052212.06398037
21Basal transcription factors_Homo sapiens_hsa030221.99755208
22Thyroid cancer_Homo sapiens_hsa052161.98032348
23Glycerolipid metabolism_Homo sapiens_hsa005611.97211614
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89127121
25mTOR signaling pathway_Homo sapiens_hsa041501.82927651
26Mismatch repair_Homo sapiens_hsa034301.81494168
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.75411670
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.75205768
29Antigen processing and presentation_Homo sapiens_hsa046121.73962962
30Fanconi anemia pathway_Homo sapiens_hsa034601.72877047
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.69857105
32Hepatitis B_Homo sapiens_hsa051611.63977536
33Prostate cancer_Homo sapiens_hsa052151.63769751
34PPAR signaling pathway_Homo sapiens_hsa033201.61931978
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60485223
36Endometrial cancer_Homo sapiens_hsa052131.59586494
37Colorectal cancer_Homo sapiens_hsa052101.59123484
38Nucleotide excision repair_Homo sapiens_hsa034201.57686070
39Oocyte meiosis_Homo sapiens_hsa041141.57198936
40MicroRNAs in cancer_Homo sapiens_hsa052061.52729701
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51333061
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49060904
43Systemic lupus erythematosus_Homo sapiens_hsa053221.42896391
44Amphetamine addiction_Homo sapiens_hsa050311.35344641
45mRNA surveillance pathway_Homo sapiens_hsa030151.33848189
46ErbB signaling pathway_Homo sapiens_hsa040121.33814536
47Small cell lung cancer_Homo sapiens_hsa052221.33733941
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33156373
49ABC transporters_Homo sapiens_hsa020101.31402162
50Mineral absorption_Homo sapiens_hsa049781.29022319
51Ether lipid metabolism_Homo sapiens_hsa005651.28385966
52Adherens junction_Homo sapiens_hsa045201.28331198
53Homologous recombination_Homo sapiens_hsa034401.28198716
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.26270218
55p53 signaling pathway_Homo sapiens_hsa041151.20527585
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19804169
57Pentose phosphate pathway_Homo sapiens_hsa000301.18782426
58One carbon pool by folate_Homo sapiens_hsa006701.17670703
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17128113
60Fructose and mannose metabolism_Homo sapiens_hsa000511.17126276
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16567555
62FoxO signaling pathway_Homo sapiens_hsa040681.15779936
63Renal cell carcinoma_Homo sapiens_hsa052111.15352129
64Glioma_Homo sapiens_hsa052141.14561529
65Inositol phosphate metabolism_Homo sapiens_hsa005621.12153756
66TGF-beta signaling pathway_Homo sapiens_hsa043501.07147044
67Renin secretion_Homo sapiens_hsa049241.05907971
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05272633
69B cell receptor signaling pathway_Homo sapiens_hsa046621.05240518
70Fat digestion and absorption_Homo sapiens_hsa049751.04868213
71RNA transport_Homo sapiens_hsa030131.04304751
72Choline metabolism in cancer_Homo sapiens_hsa052310.99415563
73Sphingolipid metabolism_Homo sapiens_hsa006000.99093326
74Bladder cancer_Homo sapiens_hsa052190.98896455
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96486198
76Spliceosome_Homo sapiens_hsa030400.96482351
77Fatty acid metabolism_Homo sapiens_hsa012120.91043652
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89731773
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89664093
80Prolactin signaling pathway_Homo sapiens_hsa049170.88510111
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.85211321
82Carbon metabolism_Homo sapiens_hsa012000.84574357
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83036869
84HTLV-I infection_Homo sapiens_hsa051660.80508585
85Fatty acid degradation_Homo sapiens_hsa000710.79973803
86Bile secretion_Homo sapiens_hsa049760.79951377
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78831728
88Long-term potentiation_Homo sapiens_hsa047200.77858930
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.77360981
90Insulin signaling pathway_Homo sapiens_hsa049100.76923671
91Steroid biosynthesis_Homo sapiens_hsa001000.76550996
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.76480246
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76389009
94Estrogen signaling pathway_Homo sapiens_hsa049150.76285214
95Apoptosis_Homo sapiens_hsa042100.76047740
96Base excision repair_Homo sapiens_hsa034100.75602263
97HIF-1 signaling pathway_Homo sapiens_hsa040660.75412869
98Endocytosis_Homo sapiens_hsa041440.74715247
99Glutathione metabolism_Homo sapiens_hsa004800.74353765
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.74327506
101Arachidonic acid metabolism_Homo sapiens_hsa005900.73950121
102Measles_Homo sapiens_hsa051620.72289948
103Chemical carcinogenesis_Homo sapiens_hsa052040.71758012
104Hepatitis C_Homo sapiens_hsa051600.70944027
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.68761241
106Melanoma_Homo sapiens_hsa052180.66786558
107Purine metabolism_Homo sapiens_hsa002300.65621088
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65612846
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65580851
110T cell receptor signaling pathway_Homo sapiens_hsa046600.65149725
111Hedgehog signaling pathway_Homo sapiens_hsa043400.64860123
112Legionellosis_Homo sapiens_hsa051340.64443600
113Thyroid hormone synthesis_Homo sapiens_hsa049180.63995166
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63770335
115TNF signaling pathway_Homo sapiens_hsa046680.63481852
116Proteoglycans in cancer_Homo sapiens_hsa052050.63450266
117Calcium signaling pathway_Homo sapiens_hsa040200.61590111
118Alcoholism_Homo sapiens_hsa050340.61172674
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58384746
120Primary immunodeficiency_Homo sapiens_hsa053400.56949319
121Osteoclast differentiation_Homo sapiens_hsa043800.56857337
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55626680
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54982947
124Viral carcinogenesis_Homo sapiens_hsa052030.52600717
125Cardiac muscle contraction_Homo sapiens_hsa042600.52575724
126Insulin secretion_Homo sapiens_hsa049110.52553721
127Influenza A_Homo sapiens_hsa051640.52529060
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.52141961
129VEGF signaling pathway_Homo sapiens_hsa043700.51525260
130Gastric acid secretion_Homo sapiens_hsa049710.50653815
131Notch signaling pathway_Homo sapiens_hsa043300.50633840
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49250949
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48970577
134Salivary secretion_Homo sapiens_hsa049700.48581010
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46793225
136GnRH signaling pathway_Homo sapiens_hsa049120.45818829
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.45783837
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45153901
139Toxoplasmosis_Homo sapiens_hsa051450.44871905
140AMPK signaling pathway_Homo sapiens_hsa041520.43382732
141Renin-angiotensin system_Homo sapiens_hsa046140.41702976
142Sulfur relay system_Homo sapiens_hsa041220.41179429
143Collecting duct acid secretion_Homo sapiens_hsa049660.40907902
144Biosynthesis of amino acids_Homo sapiens_hsa012300.40860338
145Non-homologous end-joining_Homo sapiens_hsa034500.40774515
146RNA degradation_Homo sapiens_hsa030180.38181255
147Pathways in cancer_Homo sapiens_hsa052000.37805075
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36817439
149Pancreatic secretion_Homo sapiens_hsa049720.35251760
150Protein digestion and absorption_Homo sapiens_hsa049740.33848582
151Insulin resistance_Homo sapiens_hsa049310.31398500
152Salmonella infection_Homo sapiens_hsa051320.29103809
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29035887
154cAMP signaling pathway_Homo sapiens_hsa040240.27454668
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.26975898
156Herpes simplex infection_Homo sapiens_hsa051680.26650274
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26592009
158Epstein-Barr virus infection_Homo sapiens_hsa051690.25884843
159Lysine degradation_Homo sapiens_hsa003100.25518567
160N-Glycan biosynthesis_Homo sapiens_hsa005100.25045427
161Cocaine addiction_Homo sapiens_hsa050300.24610427
162Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23574570
163Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21730092
164Type II diabetes mellitus_Homo sapiens_hsa049300.21340165

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