ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.23090422
2	piRNA metabolic process (GO:0034587)	4.65971768
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.58871346
4	synapsis (GO:0007129)	4.41431716
5	male meiosis (GO:0007140)	4.28746281
6	response to pheromone (GO:0019236)	4.21360462
7	male meiosis I (GO:0007141)	4.10061260
8	DNA methylation involved in gamete generation (GO:0043046)	3.96558638
9	regulation of cilium movement (GO:0003352)	3.95011121
10	fucose catabolic process (GO:0019317)	3.86810256
11	L-fucose metabolic process (GO:0042354)	3.86810256
12	L-fucose catabolic process (GO:0042355)	3.86810256
13	epithelial cilium movement (GO:0003351)	3.85617406
14	indolalkylamine metabolic process (GO:0006586)	3.74442320
15	cornea development in camera-type eye (GO:0061303)	3.62893937
16	negative regulation of telomere maintenance (GO:0032205)	3.53248957
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.51100040
18	tryptophan catabolic process (GO:0006569)	3.49214345
19	indole-containing compound catabolic process (GO:0042436)	3.49214345
20	indolalkylamine catabolic process (GO:0046218)	3.49214345
21	DNA deamination (GO:0045006)	3.29173064
22	tryptophan metabolic process (GO:0006568)	3.29034757
23	respiratory chain complex IV assembly (GO:0008535)	3.21594953
24	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.18989160
25	axonemal dynein complex assembly (GO:0070286)	3.17738316
26	platelet dense granule organization (GO:0060155)	3.17161063
27	cilium movement (GO:0003341)	3.16427831
28	reciprocal DNA recombination (GO:0035825)	3.14293913
29	reciprocal meiotic recombination (GO:0007131)	3.14293913
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12976155
31	protein polyglutamylation (GO:0018095)	3.09671402
32	regulation of microtubule-based movement (GO:0060632)	3.08440387
33	meiosis I (GO:0007127)	3.07844019
34	chromosome organization involved in meiosis (GO:0070192)	3.07708199
35	detection of light stimulus involved in visual perception (GO:0050908)	3.05992690
36	detection of light stimulus involved in sensory perception (GO:0050962)	3.05992690
37	axoneme assembly (GO:0035082)	3.04689591
38	protein complex biogenesis (GO:0070271)	3.01159477
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99163525
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99163525
41	NADH dehydrogenase complex assembly (GO:0010257)	2.99163525
42	sperm motility (GO:0030317)	2.94453471
43	multicellular organism reproduction (GO:0032504)	2.93941492
44	kynurenine metabolic process (GO:0070189)	2.93736741
45	cilium morphogenesis (GO:0060271)	2.91098693
46	cilium or flagellum-dependent cell motility (GO:0001539)	2.86021625
47	sulfation (GO:0051923)	2.85325903
48	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.82056894
49	preassembly of GPI anchor in ER membrane (GO:0016254)	2.79198411
50	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74331205
51	protein neddylation (GO:0045116)	2.70956082
52	cellular ketone body metabolic process (GO:0046950)	2.70644533
53	cytochrome complex assembly (GO:0017004)	2.70587757
54	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.69536938
55	behavioral response to ethanol (GO:0048149)	2.67732955
56	regulation of meiosis I (GO:0060631)	2.66526948
57	indole-containing compound metabolic process (GO:0042430)	2.65007357
58	DNA double-strand break processing (GO:0000729)	2.63346372
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.62715898
60	pyrimidine nucleobase catabolic process (GO:0006208)	2.62713994
61	somite development (GO:0061053)	2.61031131
62	neuronal action potential (GO:0019228)	2.60992262
63	glycerophospholipid catabolic process (GO:0046475)	2.60331409
64	neural tube formation (GO:0001841)	2.59806509
65	meiotic nuclear division (GO:0007126)	2.59157224
66	regulation of telomere maintenance (GO:0032204)	2.57600996
67	mannosylation (GO:0097502)	2.57316381
68	ubiquinone biosynthetic process (GO:0006744)	2.56997832
69	photoreceptor cell maintenance (GO:0045494)	2.56848132
70	resolution of meiotic recombination intermediates (GO:0000712)	2.54879680
71	cilium organization (GO:0044782)	2.53272164
72	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.52457090
73	retinal cone cell development (GO:0046549)	2.51792945
74	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.51753128
75	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.50440293
76	protein K11-linked deubiquitination (GO:0035871)	2.50122003
77	protein localization to cilium (GO:0061512)	2.50094738
78	spermatid development (GO:0007286)	2.49647180
79	kidney morphogenesis (GO:0060993)	2.47522013
80	ubiquinone metabolic process (GO:0006743)	2.46498550
81	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.45900658
82	recombinational repair (GO:0000725)	2.44626033
83	hindbrain development (GO:0030902)	2.44242976
84	cilium assembly (GO:0042384)	2.44122506
85	double-strand break repair via homologous recombination (GO:0000724)	2.42722361
86	cellular biogenic amine catabolic process (GO:0042402)	2.42401499
87	amine catabolic process (GO:0009310)	2.42401499
88	rhodopsin mediated signaling pathway (GO:0016056)	2.42123820
89	replication fork processing (GO:0031297)	2.42048168
90	ketone body metabolic process (GO:1902224)	2.41880891
91	photoreceptor cell development (GO:0042461)	2.39466775
92	acrosome reaction (GO:0007340)	2.39133063
93	intraciliary transport (GO:0042073)	2.39122639
94	ovulation cycle (GO:0042698)	2.37952501
95	nonmotile primary cilium assembly (GO:0035058)	2.36971495
96	regulation of posttranscriptional gene silencing (GO:0060147)	2.36796697
97	regulation of gene silencing by miRNA (GO:0060964)	2.36796697
98	regulation of gene silencing by RNA (GO:0060966)	2.36796697
99	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.36357573
100	positive regulation of fatty acid transport (GO:2000193)	2.35731423

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92055405
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.85017058
3	VDR_22108803_ChIP-Seq_LS180_Human	3.32045136
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.04957315
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.63539660
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.56184192
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40386388
8	FUS_26573619_Chip-Seq_HEK293_Human	2.37799893
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37694505
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32127701
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.23367293
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.13578461
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13461990
14	EWS_26573619_Chip-Seq_HEK293_Human	2.07746255
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06880744
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05855499
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.05263668
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.04030629
19	P300_19829295_ChIP-Seq_ESCs_Human	1.98235431
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.95813032
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.88398721
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79016805
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.73632377
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.64278011
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.63893850
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.62164613
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61129217
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.60727535
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58819476
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58122443
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57422791
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56766934
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56662205
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.55326062
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.54715875
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54715875
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54076144
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49617589
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49617589
40	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.49016115
41	AR_25329375_ChIP-Seq_VCAP_Human	1.47080833
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46801453
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.43561515
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42456069
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42456069
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.40779213
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40571644
48	STAT3_23295773_ChIP-Seq_U87_Human	1.39576394
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39230316
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38294804
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.38089351
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34685850
53	TCF4_23295773_ChIP-Seq_U87_Human	1.34181938
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33333182
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31127381
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27849665
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27142125
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27120814
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.27113016
60	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27069131
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26498382
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26434199
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23758550
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23476553
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23476553
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18950932
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18856226
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17356965
69	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17247977
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16950281
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16453914
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16358441
73	NCOR_22424771_ChIP-Seq_293T_Human	1.13909330
74	AR_20517297_ChIP-Seq_VCAP_Human	1.12277255
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12067108
76	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.11967679
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10438692
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.08769143
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08331140
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07939712
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07612381
82	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04413615
83	VDR_23849224_ChIP-Seq_CD4+_Human	1.03795123
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03674219
85	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02491902
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02215305
87	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01617293
88	ERA_21632823_ChIP-Seq_H3396_Human	1.00593347
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00324850
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.99126752
91	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.98334868
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97577255
93	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.97316513
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95650545
95	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.95308982
96	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94566028
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94229094
98	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93000125
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92591774
100	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92294748

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.69585808
2	MP0006292_abnormal_olfactory_placode	3.00011425
3	MP0003787_abnormal_imprinting	2.46273158
4	MP0003646_muscle_fatigue	2.43788935
5	MP0005551_abnormal_eye_electrophysiolog	2.36927246
6	MP0002102_abnormal_ear_morphology	2.30360156
7	MP0002638_abnormal_pupillary_reflex	2.25906676
8	MP0001968_abnormal_touch/_nociception	2.22745177
9	MP0008995_early_reproductive_senescence	2.13987730
10	MP0006072_abnormal_retinal_apoptosis	2.05643987
11	MP0000569_abnormal_digit_pigmentation	2.05554998
12	MP0003195_calcinosis	1.97542496
13	MP0003880_abnormal_central_pattern	1.94943347
14	MP0005253_abnormal_eye_physiology	1.86545935
15	MP0005646_abnormal_pituitary_gland	1.85559456
16	MP0002160_abnormal_reproductive_system	1.83393734
17	MP0002736_abnormal_nociception_after	1.80897953
18	MP0003136_yellow_coat_color	1.80746613
19	MP0000372_irregular_coat_pigmentation	1.77955999
20	MP0001529_abnormal_vocalization	1.77673275
21	MP0002837_dystrophic_cardiac_calcinosis	1.77547158
22	MP0009745_abnormal_behavioral_response	1.76316625
23	MP0005410_abnormal_fertilization	1.73701788
24	MP0009046_muscle_twitch	1.73538520
25	MP0005389_reproductive_system_phenotype	1.71777872
26	MP0001501_abnormal_sleep_pattern	1.71306800
27	MP0006276_abnormal_autonomic_nervous	1.65110807
28	MP0005645_abnormal_hypothalamus_physiol	1.63566528
29	MP0008872_abnormal_physiological_respon	1.63537805
30	MP0002272_abnormal_nervous_system	1.60307151
31	MP0008789_abnormal_olfactory_epithelium	1.57856711
32	MP0002876_abnormal_thyroid_physiology	1.56880174
33	MP0004133_heterotaxia	1.54852556
34	MP0001919_abnormal_reproductive_system	1.53592584
35	MP0001984_abnormal_olfaction	1.51232258
36	MP0004043_abnormal_pH_regulation	1.50408216
37	MP0004142_abnormal_muscle_tone	1.48479578
38	MP0005174_abnormal_tail_pigmentation	1.46875343
39	MP0000631_abnormal_neuroendocrine_gland	1.46529533
40	MP0000427_abnormal_hair_cycle	1.45043764
41	MP0002938_white_spotting	1.44640978
42	MP0008058_abnormal_DNA_repair	1.43331914
43	MP0002653_abnormal_ependyma_morphology	1.37951511
44	MP0008875_abnormal_xenobiotic_pharmacok	1.36270829
45	MP0003698_abnormal_male_reproductive	1.36141399
46	MP0001905_abnormal_dopamine_level	1.35626418
47	MP0002210_abnormal_sex_determination	1.35252655
48	MP0004885_abnormal_endolymph	1.35011463
49	MP0005499_abnormal_olfactory_system	1.33760916
50	MP0005394_taste/olfaction_phenotype	1.33760916
51	MP0003121_genomic_imprinting	1.33374408
52	MP0001485_abnormal_pinna_reflex	1.30963209
53	MP0002234_abnormal_pharynx_morphology	1.30708792
54	MP0003718_maternal_effect	1.30708026
55	MP0001929_abnormal_gametogenesis	1.29461237
56	MP0003011_delayed_dark_adaptation	1.29117621
57	MP0005187_abnormal_penis_morphology	1.27364010
58	MP0002557_abnormal_social/conspecific_i	1.22440844
59	MP0001486_abnormal_startle_reflex	1.20916301
60	MP0001986_abnormal_taste_sensitivity	1.20294383
61	MP0002064_seizures	1.17068614
62	MP0002572_abnormal_emotion/affect_behav	1.16334595
63	MP0005167_abnormal_blood-brain_barrier	1.15390125
64	MP0003786_premature_aging	1.13914596
65	MP0000778_abnormal_nervous_system	1.13794840
66	MP0001502_abnormal_circadian_rhythm	1.09860340
67	MP0004147_increased_porphyrin_level	1.08411908
68	MP0001970_abnormal_pain_threshold	1.08081072
69	MP0005386_behavior/neurological_phenoty	1.07485983
70	MP0004924_abnormal_behavior	1.07485983
71	MP0000653_abnormal_sex_gland	1.07192624
72	MP0001145_abnormal_male_reproductive	1.06988918
73	MP0005195_abnormal_posterior_eye	1.04248913
74	MP0002751_abnormal_autonomic_nervous	1.01160410
75	MP0003635_abnormal_synaptic_transmissio	1.00596845
76	MP0002095_abnormal_skin_pigmentation	1.00256463
77	MP0002735_abnormal_chemical_nociception	1.00091031
78	MP0002184_abnormal_innervation	1.00002715
79	MP0002733_abnormal_thermal_nociception	0.99983436
80	MP0005075_abnormal_melanosome_morpholog	0.98803835
81	MP0002067_abnormal_sensory_capabilities	0.96665425
82	MP0003122_maternal_imprinting	0.95086090
83	MP0002752_abnormal_somatic_nervous	0.94971856
84	MP0003937_abnormal_limbs/digits/tail_de	0.91697293
85	MP0002063_abnormal_learning/memory/cond	0.91695450
86	MP0003315_abnormal_perineum_morphology	0.91272346
87	MP0004145_abnormal_muscle_electrophysio	0.90577150
88	MP0004742_abnormal_vestibular_system	0.89973697
89	MP0001324_abnormal_eye_pigmentation	0.89830178
90	MP0003119_abnormal_digestive_system	0.89398362
91	MP0000647_abnormal_sebaceous_gland	0.88160045
92	MP0000383_abnormal_hair_follicle	0.86334844
93	MP0003890_abnormal_embryonic-extraembry	0.85198867
94	MP0009697_abnormal_copulation	0.84875783
95	MP0000015_abnormal_ear_pigmentation	0.83035486
96	MP0003878_abnormal_ear_physiology	0.82561716
97	MP0005377_hearing/vestibular/ear_phenot	0.82561716
98	MP0000049_abnormal_middle_ear	0.78910371
99	MP0005391_vision/eye_phenotype	0.78659901
100	MP0010386_abnormal_urinary_bladder	0.78573680

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.17101688
2	Pancreatic cysts (HP:0001737)	4.14784747
3	Pancreatic fibrosis (HP:0100732)	3.85794452
4	Molar tooth sign on MRI (HP:0002419)	3.68226514
5	Abnormality of midbrain morphology (HP:0002418)	3.68226514
6	True hermaphroditism (HP:0010459)	3.64567147
7	Nephronophthisis (HP:0000090)	3.45515790
8	Type II lissencephaly (HP:0007260)	3.35733976
9	Abnormality of the renal cortex (HP:0011035)	3.07257729
10	Abnormality of the renal medulla (HP:0100957)	3.05539041
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.86938468
12	Absent/shortened dynein arms (HP:0200106)	2.86938468
13	Cystic liver disease (HP:0006706)	2.73508055
14	Abnormal respiratory epithelium morphology (HP:0012253)	2.72767504
15	Abnormal respiratory motile cilium morphology (HP:0005938)	2.72767504
16	Pendular nystagmus (HP:0012043)	2.69212546
17	Abnormality of the labia minora (HP:0012880)	2.64922266
18	Medial flaring of the eyebrow (HP:0010747)	2.63851007
19	Polydipsia (HP:0001959)	2.57405678
20	Abnormal drinking behavior (HP:0030082)	2.57405678
21	Attenuation of retinal blood vessels (HP:0007843)	2.55990411
22	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.55476372
23	Hypoplasia of the fovea (HP:0007750)	2.55476372
24	Mitochondrial inheritance (HP:0001427)	2.55115830
25	Hyperventilation (HP:0002883)	2.54400286
26	Acute necrotizing encephalopathy (HP:0006965)	2.53722975
27	Increased CSF lactate (HP:0002490)	2.45093370
28	Abnormal ciliary motility (HP:0012262)	2.43338503
29	Cerebellar dysplasia (HP:0007033)	2.39683999
30	Lissencephaly (HP:0001339)	2.39172239
31	Increased corneal curvature (HP:0100692)	2.38217541
32	Keratoconus (HP:0000563)	2.38217541
33	Tubular atrophy (HP:0000092)	2.37563485
34	Abolished electroretinogram (ERG) (HP:0000550)	2.36915428
35	Chronic hepatic failure (HP:0100626)	2.32618916
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.32065916
37	Hepatocellular necrosis (HP:0001404)	2.29811125
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.27682497
39	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.26667401
40	Progressive macrocephaly (HP:0004481)	2.26281772
41	Methylmalonic acidemia (HP:0002912)	2.26222851
42	Optic nerve hypoplasia (HP:0000609)	2.25026475
43	Hypothermia (HP:0002045)	2.23052871
44	Methylmalonic aciduria (HP:0012120)	2.22796259
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21734207
46	Sclerocornea (HP:0000647)	2.21555204
47	Male pseudohermaphroditism (HP:0000037)	2.21330151
48	3-Methylglutaconic aciduria (HP:0003535)	2.21169374
49	Acute encephalopathy (HP:0006846)	2.20493058
50	Renal cortical cysts (HP:0000803)	2.16391850
51	Polyuria (HP:0000103)	2.16335950
52	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.15508889
53	Abnormality of the fovea (HP:0000493)	2.15030235
54	Inability to walk (HP:0002540)	2.14949205
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13741412
56	Abnormality of alanine metabolism (HP:0010916)	2.13741412
57	Hyperalaninemia (HP:0003348)	2.13741412
58	Oligodactyly (hands) (HP:0001180)	2.11821585
59	Gait imbalance (HP:0002141)	2.11577157
60	Broad-based gait (HP:0002136)	2.10729478
61	Hepatic necrosis (HP:0002605)	2.10332157
62	Bile duct proliferation (HP:0001408)	2.09355012
63	Abnormal biliary tract physiology (HP:0012439)	2.09355012
64	Congenital hepatic fibrosis (HP:0002612)	2.06168528
65	Optic disc pallor (HP:0000543)	2.04680465
66	Pachygyria (HP:0001302)	2.03957242
67	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03395982
68	Congenital primary aphakia (HP:0007707)	1.99052713
69	Absent thumb (HP:0009777)	1.97088999
70	Lipid accumulation in hepatocytes (HP:0006561)	1.96429471
71	Aplasia/hypoplasia of the uterus (HP:0008684)	1.96131131
72	Protruding tongue (HP:0010808)	1.95912148
73	Retinal dysplasia (HP:0007973)	1.94932452
74	Anencephaly (HP:0002323)	1.94460875
75	Decreased central vision (HP:0007663)	1.93352342
76	Concave nail (HP:0001598)	1.92053354
77	Postaxial foot polydactyly (HP:0001830)	1.90817665
78	Gaze-evoked nystagmus (HP:0000640)	1.88299611
79	Abnormality of macular pigmentation (HP:0008002)	1.87471179
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86036824
81	Patellar aplasia (HP:0006443)	1.85191071
82	Nephrogenic diabetes insipidus (HP:0009806)	1.84120078
83	Abnormality of the pons (HP:0007361)	1.82530705
84	Increased hepatocellular lipid droplets (HP:0006565)	1.80786862
85	Progressive cerebellar ataxia (HP:0002073)	1.80413473
86	Hypoplasia of the pons (HP:0012110)	1.80086616
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78310021
88	Aplasia/Hypoplasia of the patella (HP:0006498)	1.77818651
89	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.76369752
90	Occipital encephalocele (HP:0002085)	1.74934552
91	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73821110
92	Focal motor seizures (HP:0011153)	1.72499257
93	Bony spicule pigmentary retinopathy (HP:0007737)	1.72108165
94	Hyperglycinemia (HP:0002154)	1.71933003
95	Ketosis (HP:0001946)	1.71909773
96	Hypomagnesemia (HP:0002917)	1.71462604
97	Abnormal urine output (HP:0012590)	1.71277032
98	Congenital sensorineural hearing impairment (HP:0008527)	1.70007946
99	Congenital, generalized hypertrichosis (HP:0004540)	1.70006357
100	Thyroiditis (HP:0100646)	1.68340149

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.30422968
2	ZAK	3.40974542
3	PINK1	3.30690174
4	MAP4K2	3.12289412
5	BMPR1B	3.07885176
6	ADRBK2	2.95791567
7	PNCK	2.72123928
8	GRK1	2.58078474
9	WNK4	2.57371410
10	TLK1	2.47947916
11	WNK3	2.21802666
12	MAPK13	2.14632574
13	NUAK1	2.09147731
14	TAOK3	2.08169896
15	MARK1	1.87702320
16	ACVR1B	1.83411630
17	MAP3K4	1.80935794
18	OXSR1	1.69783533
19	CASK	1.65402714
20	STK39	1.53184192
21	INSRR	1.48981739
22	PTK2B	1.47798177
23	DYRK2	1.40739108
24	MAP2K7	1.29011892
25	CSNK1G1	1.27833064
26	TNIK	1.16722419
27	VRK1	1.16607869
28	CSNK1G3	1.15805742
29	CSNK1G2	1.15580399
30	STK16	1.09413048
31	TRIM28	1.09233698
32	DAPK2	1.09158069
33	PRKCG	1.08234775
34	MKNK2	1.04458268
35	CDK19	1.04180218
36	ADRBK1	1.02062114
37	WEE1	1.00415696
38	PLK2	0.99222945
39	CSNK1A1L	0.94809077
40	MAPKAPK3	0.93497954
41	TXK	0.91445581
42	VRK2	0.87312065
43	PAK3	0.87131205
44	EPHA4	0.86279975
45	BCKDK	0.83658012
46	TGFBR1	0.80688723
47	PRKCE	0.80380431
48	MARK3	0.78218340
49	STK38L	0.77244262
50	RPS6KA5	0.74478463
51	PHKG1	0.74269389
52	PHKG2	0.74269389
53	TIE1	0.74042854
54	PRKCI	0.72578349
55	PLK4	0.67936004
56	PRKCQ	0.66364253
57	MST4	0.64254714
58	NTRK2	0.64136698
59	CAMK1	0.57730106
60	DYRK3	0.57024688
61	CAMKK2	0.56201690
62	FGFR2	0.51669236
63	PLK3	0.51392462
64	MINK1	0.50589417
65	ERBB3	0.50515757
66	NLK	0.50072811
67	MAPKAPK5	0.49794214
68	CCNB1	0.49281302
69	DYRK1A	0.48831836
70	BCR	0.48671681
71	CSNK1A1	0.46969342
72	PLK1	0.46023906
73	ATR	0.43970322
74	CAMK2A	0.43652791
75	MUSK	0.42164933
76	PRKACA	0.41237918
77	MKNK1	0.40832466
78	BRSK2	0.39335477
79	NTRK3	0.39243388
80	MAPK15	0.38932542
81	MAP2K4	0.38896363
82	NME1	0.37676086
83	SGK2	0.37377302
84	SGK223	0.36924372
85	SGK494	0.36924372
86	SRPK1	0.36746944
87	EIF2AK3	0.36555256
88	PRKG1	0.35501197
89	IKBKB	0.35354136
90	ATM	0.32816616
91	TNK2	0.32651886
92	PKN1	0.31890941
93	PRKCZ	0.31406604
94	CHEK2	0.31200547
95	MET	0.30960224
96	IRAK1	0.30037025
97	GRK5	0.29804497
98	PRKCA	0.29675985
99	CSNK1E	0.28440689
100	OBSCN	0.28122587

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.05670475
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.55805055
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.54477190
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.40124066
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.35010293
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.22856350
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.19252013
8	Butanoate metabolism_Homo sapiens_hsa00650	2.17428661
9	Parkinsons disease_Homo sapiens_hsa05012	2.14758049
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.13043467
11	Homologous recombination_Homo sapiens_hsa03440	2.06138484
12	Nicotine addiction_Homo sapiens_hsa05033	2.05106002
13	Protein export_Homo sapiens_hsa03060	2.03025388
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.89363468
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.83433316
16	Basal transcription factors_Homo sapiens_hsa03022	1.80783449
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80611135
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79797200
19	Propanoate metabolism_Homo sapiens_hsa00640	1.75946590
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.72349308
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.70054725
22	RNA polymerase_Homo sapiens_hsa03020	1.68312300
23	Caffeine metabolism_Homo sapiens_hsa00232	1.60084127
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.59127907
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.55267215
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.52021432
27	Huntingtons disease_Homo sapiens_hsa05016	1.50626777
28	Olfactory transduction_Homo sapiens_hsa04740	1.47814110
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43580008
30	RNA degradation_Homo sapiens_hsa03018	1.42154860
31	One carbon pool by folate_Homo sapiens_hsa00670	1.28887614
32	Alzheimers disease_Homo sapiens_hsa05010	1.27479456
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.27257155
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24471482
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23270545
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21257551
37	Taste transduction_Homo sapiens_hsa04742	1.20182446
38	Morphine addiction_Homo sapiens_hsa05032	1.14400771
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.12933728
40	Peroxisome_Homo sapiens_hsa04146	1.11017019
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.07740639
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.05838212
43	Regulation of autophagy_Homo sapiens_hsa04140	1.05673938
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04378203
45	Retinol metabolism_Homo sapiens_hsa00830	1.01382059
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97849260
47	Proteasome_Homo sapiens_hsa03050	0.94446449
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93860884
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92481298
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91424610
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.89914402
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89909517
53	GABAergic synapse_Homo sapiens_hsa04727	0.88946676
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.87060572
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.83403002
56	Circadian entrainment_Homo sapiens_hsa04713	0.81176189
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.80014025
58	Insulin secretion_Homo sapiens_hsa04911	0.78863794
59	Primary immunodeficiency_Homo sapiens_hsa05340	0.75342694
60	Serotonergic synapse_Homo sapiens_hsa04726	0.75216398
61	Purine metabolism_Homo sapiens_hsa00230	0.74695154
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73686447
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.72540834
64	Ribosome_Homo sapiens_hsa03010	0.72093686
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.70924844
66	Metabolic pathways_Homo sapiens_hsa01100	0.69136929
67	ABC transporters_Homo sapiens_hsa02010	0.68951389
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68605646
69	Sulfur relay system_Homo sapiens_hsa04122	0.65881517
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64889130
71	Salivary secretion_Homo sapiens_hsa04970	0.64850600
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.64628010
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63555602
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62903979
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62192017
76	Asthma_Homo sapiens_hsa05310	0.60988530
77	Sulfur metabolism_Homo sapiens_hsa00920	0.60911173
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59548288
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.57887190
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57738501
81	Fatty acid degradation_Homo sapiens_hsa00071	0.57655053
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56283280
83	RNA transport_Homo sapiens_hsa03013	0.54315800
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52681977
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48398375
86	Mineral absorption_Homo sapiens_hsa04978	0.47095402
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46519404
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.45905826
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45048841
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44578215
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42689261
92	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42009694
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40982768
94	Circadian rhythm_Homo sapiens_hsa04710	0.38073964
95	Histidine metabolism_Homo sapiens_hsa00340	0.37895662
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35055484
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33809891
98	Base excision repair_Homo sapiens_hsa03410	0.31255116
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.30931790
100	Mismatch repair_Homo sapiens_hsa03430	0.30808966

ANKRD62

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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