ANKRD63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.14634174
2regulation of synapse structural plasticity (GO:0051823)5.83824898
3locomotory exploration behavior (GO:0035641)5.69858525
4synaptic vesicle maturation (GO:0016188)5.63362339
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54139031
6synaptic transmission, dopaminergic (GO:0001963)5.48401396
7prepulse inhibition (GO:0060134)5.45167718
8regulation of long-term neuronal synaptic plasticity (GO:0048169)5.25350651
9vocalization behavior (GO:0071625)5.24229830
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15269269
11adenosine receptor signaling pathway (GO:0001973)4.95792211
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94742919
13regulation of glutamate receptor signaling pathway (GO:1900449)4.93370165
14regulation of neuronal synaptic plasticity (GO:0048168)4.85695206
15striatum development (GO:0021756)4.71095436
16regulation of dendritic spine morphogenesis (GO:0061001)4.67503524
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.65032427
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.59874962
19synaptic vesicle exocytosis (GO:0016079)4.59354820
20response to amphetamine (GO:0001975)4.53456146
21dendritic spine morphogenesis (GO:0060997)4.53182075
22adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.51558632
23auditory behavior (GO:0031223)4.50030080
24neurotransmitter-gated ion channel clustering (GO:0072578)4.46567924
25positive regulation of synaptic transmission, GABAergic (GO:0032230)4.41813271
26positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.39327295
27synaptic vesicle docking involved in exocytosis (GO:0016081)4.38575241
28positive regulation of neurotransmitter transport (GO:0051590)4.34126073
29protein localization to synapse (GO:0035418)4.29780758
30regulation of synaptic vesicle exocytosis (GO:2000300)4.29182284
31G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.26074444
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.21537098
33negative regulation of cytosolic calcium ion concentration (GO:0051481)4.19822599
34dopamine receptor signaling pathway (GO:0007212)4.19039202
35neuromuscular process controlling balance (GO:0050885)4.18006895
36regulation of female receptivity (GO:0045924)4.17730019
37neuron-neuron synaptic transmission (GO:0007270)4.17357227
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.17112100
39regulation of glutamate secretion (GO:0014048)4.15546165
40behavioral response to cocaine (GO:0048148)4.14866310
41exploration behavior (GO:0035640)4.13345911
42positive regulation of neurotransmitter secretion (GO:0001956)4.06995503
43long-term memory (GO:0007616)4.05649385
44positive regulation of membrane potential (GO:0045838)4.04867986
45negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.03431921
46synaptic transmission, glutamatergic (GO:0035249)4.02891459
47neurotransmitter secretion (GO:0007269)4.00066256
48glutamate receptor signaling pathway (GO:0007215)3.95583527
49response to auditory stimulus (GO:0010996)3.92214991
50regulation of synaptic plasticity (GO:0048167)3.88760056
51regulation of postsynaptic membrane potential (GO:0060078)3.86893442
52regulation of synaptic vesicle transport (GO:1902803)3.86033063
53neuronal action potential propagation (GO:0019227)3.85932338
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.81090349
55cAMP catabolic process (GO:0006198)3.80884484
56glutamate secretion (GO:0014047)3.78336065
57regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.77190910
58regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.77190910
59layer formation in cerebral cortex (GO:0021819)3.74023403
60behavioral defense response (GO:0002209)3.72787067
61behavioral fear response (GO:0001662)3.72787067
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72702384
63neuronal ion channel clustering (GO:0045161)3.67828212
64female mating behavior (GO:0060180)3.67495475
65transmission of nerve impulse (GO:0019226)3.66673017
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65925484
67long-term synaptic potentiation (GO:0060291)3.65342085
68regulation of dendritic spine development (GO:0060998)3.61519606
69response to histamine (GO:0034776)3.57977926
70visual learning (GO:0008542)3.54361614
71activation of protein kinase A activity (GO:0034199)3.53602136
72gamma-aminobutyric acid transport (GO:0015812)3.51830359
73substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.51339961
74substrate-independent telencephalic tangential migration (GO:0021826)3.51339961
75negative regulation of dendrite development (GO:2000171)3.49416194
76negative regulation of amino acid transport (GO:0051956)3.44930358
77dendritic spine organization (GO:0097061)3.44721839
78regulation of neurotransmitter uptake (GO:0051580)3.43265572
79phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.39978946
80neuron cell-cell adhesion (GO:0007158)3.37727414
81mechanosensory behavior (GO:0007638)3.35849973
82visual behavior (GO:0007632)3.34605002
83regulation of voltage-gated calcium channel activity (GO:1901385)3.33955664
84fear response (GO:0042596)3.33422585
85learning (GO:0007612)3.33301880
86cyclic nucleotide catabolic process (GO:0009214)3.31180947
87membrane hyperpolarization (GO:0060081)3.30430903
88cAMP metabolic process (GO:0046058)3.29780924
89glycine transport (GO:0015816)3.27489611
90regulation of synaptic transmission, GABAergic (GO:0032228)3.22895767
91membrane depolarization (GO:0051899)3.22694281
92positive regulation of synaptic transmission (GO:0050806)3.22324460
93positive regulation of dendritic spine development (GO:0060999)3.21139056
94regulation of protein kinase A signaling (GO:0010738)3.20412524
95mating behavior (GO:0007617)3.15730423
96positive regulation of dendritic spine morphogenesis (GO:0061003)3.14786000
97response to amine (GO:0014075)3.12915030
98neuromuscular process (GO:0050905)3.12496220
99cAMP biosynthetic process (GO:0006171)3.12059131
100cellular potassium ion homeostasis (GO:0030007)3.11615458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43188961
2RARB_27405468_Chip-Seq_BRAIN_Mouse4.00896255
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21796436
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16752430
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12419260
6GBX2_23144817_ChIP-Seq_PC3_Human3.04189477
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.01012910
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82178657
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82178657
10DROSHA_22980978_ChIP-Seq_HELA_Human2.80909989
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79335295
12REST_21632747_ChIP-Seq_MESCs_Mouse2.74541109
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72543103
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.67213377
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64299799
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61853365
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.51623495
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.48893937
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42502056
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38927572
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35579021
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.32876301
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.26861528
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.26836933
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.03593376
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.96655500
27AR_21572438_ChIP-Seq_LNCaP_Human1.88322584
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88260191
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69274272
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61667244
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54295978
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47340147
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41353094
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40502117
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37971657
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37958830
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37248092
38SMAD4_21799915_ChIP-Seq_A2780_Human1.36700763
39KDM2B_26808549_Chip-Seq_K562_Human1.35503603
40WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34546206
41TAF15_26573619_Chip-Seq_HEK293_Human1.34140857
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.33556193
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30346867
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29637487
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27892839
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26513731
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26399845
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25904829
49P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22830413
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19864861
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.19496715
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.18444947
53AR_19668381_ChIP-Seq_PC3_Human1.17333992
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16040752
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15290070
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.14574708
57SMAD3_21741376_ChIP-Seq_HESCs_Human1.11868594
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10410633
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09203076
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09073129
61CTCF_27219007_Chip-Seq_Bcells_Human1.07082658
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06497573
63STAT3_23295773_ChIP-Seq_U87_Human1.05874773
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05149101
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03626042
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00979866
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00349464
68P300_19829295_ChIP-Seq_ESCs_Human0.99586317
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98261863
70ZNF274_21170338_ChIP-Seq_K562_Hela0.97478488
71AR_25329375_ChIP-Seq_VCAP_Human0.96498490
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95255597
73KLF4_19829295_ChIP-Seq_ESCs_Human0.93396599
74YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92543064
75TCF4_23295773_ChIP-Seq_U87_Human0.91813318
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91701752
77ESR1_20079471_ChIP-ChIP_T-47D_Human0.91294653
78SMAD_19615063_ChIP-ChIP_OVARY_Human0.91140756
79RXR_22108803_ChIP-Seq_LS180_Human0.90158267
80TET1_21490601_ChIP-Seq_MESCs_Mouse0.89915926
81ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89085377
82AHR_22903824_ChIP-Seq_MCF-7_Human0.88790247
83SMAD3_21741376_ChIP-Seq_ESCs_Human0.88377512
84TP53_16413492_ChIP-PET_HCT116_Human0.88291508
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.88072459
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87577811
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86970871
88RUNX2_22187159_ChIP-Seq_PCA_Human0.85621457
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.85473238
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85429554
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.85250601
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.85214077
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85003657
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84842530
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83584979
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82593385
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79656695
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.78801001
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78640047
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77184134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.96334876
2MP0004859_abnormal_synaptic_plasticity6.85264849
3MP0003880_abnormal_central_pattern4.44790743
4MP0003635_abnormal_synaptic_transmissio4.28361620
5MP0009745_abnormal_behavioral_response3.83442488
6MP0002063_abnormal_learning/memory/cond3.62630704
7MP0004270_analgesia3.48920625
8MP0002064_seizures3.09239963
9MP0002572_abnormal_emotion/affect_behav2.88377871
10MP0001486_abnormal_startle_reflex2.72640826
11MP0009046_muscle_twitch2.69877461
12MP0001529_abnormal_vocalization2.66634421
13MP0001968_abnormal_touch/_nociception2.62110926
14MP0002272_abnormal_nervous_system2.52469256
15MP0002909_abnormal_adrenal_gland2.37838210
16MP0005423_abnormal_somatic_nervous2.28000684
17MP0001501_abnormal_sleep_pattern2.22723172
18MP0002734_abnormal_mechanical_nocicepti2.03881296
19MP0005646_abnormal_pituitary_gland1.96629981
20MP0004924_abnormal_behavior1.89150403
21MP0005386_behavior/neurological_phenoty1.89150403
22MP0009780_abnormal_chondrocyte_physiolo1.88462272
23MP0002736_abnormal_nociception_after1.86434485
24MP0005409_darkened_coat_color1.82184710
25MP0001970_abnormal_pain_threshold1.76835765
26MP0004811_abnormal_neuron_physiology1.68679984
27MP0002733_abnormal_thermal_nociception1.68489440
28MP0001440_abnormal_grooming_behavior1.67854692
29MP0008569_lethality_at_weaning1.66698555
30MP0001984_abnormal_olfaction1.65410803
31MP0002557_abnormal_social/conspecific_i1.64530995
32MP0010234_abnormal_vibrissa_follicle1.59585338
33MP0003075_altered_response_to1.56839099
34MP0003879_abnormal_hair_cell1.56484513
35MP0003329_amyloid_beta_deposits1.48692113
36MP0002067_abnormal_sensory_capabilities1.47280792
37MP0001188_hyperpigmentation1.43717894
38MP0005167_abnormal_blood-brain_barrier1.39624833
39MP0008874_decreased_physiological_sensi1.36616425
40MP0003633_abnormal_nervous_system1.34417046
41MP0004885_abnormal_endolymph1.33512329
42MP0002735_abnormal_chemical_nociception1.33267549
43MP0002066_abnormal_motor_capabilities/c1.28271074
44MP0001905_abnormal_dopamine_level1.27587823
45MP0008872_abnormal_physiological_respon1.26109690
46MP0002184_abnormal_innervation1.25735960
47MP0000955_abnormal_spinal_cord1.20361921
48MP0000013_abnormal_adipose_tissue1.18250471
49MP0001177_atelectasis1.15842913
50MP0002882_abnormal_neuron_morphology1.11741735
51MP0004858_abnormal_nervous_system1.10036823
52MP0008961_abnormal_basal_metabolism1.08711492
53MP0000778_abnormal_nervous_system1.08204202
54MP0003631_nervous_system_phenotype1.04106417
55MP0004085_abnormal_heartbeat1.03684426
56MP0003283_abnormal_digestive_organ0.97668093
57MP0003787_abnormal_imprinting0.96951265
58MP0001502_abnormal_circadian_rhythm0.96879696
59MP0005535_abnormal_body_temperature0.95373247
60MP0002069_abnormal_eating/drinking_beha0.95030983
61MP0000751_myopathy0.93701621
62MP0003690_abnormal_glial_cell0.90572023
63MP0002152_abnormal_brain_morphology0.88206100
64MP0000920_abnormal_myelination0.84638860
65MP0002090_abnormal_vision0.83320658
66MP0004142_abnormal_muscle_tone0.82765880
67MP0000569_abnormal_digit_pigmentation0.79085533
68MP0003137_abnormal_impulse_conducting0.71275092
69MP0005645_abnormal_hypothalamus_physiol0.70434745
70MP0005394_taste/olfaction_phenotype0.70395060
71MP0005499_abnormal_olfactory_system0.70395060
72MP0002229_neurodegeneration0.69262673
73MP0005166_decreased_susceptibility_to0.69221140
74MP0000604_amyloidosis0.65262759
75MP0003634_abnormal_glial_cell0.61458447
76MP0001664_abnormal_digestion0.60940741
77MP0000631_abnormal_neuroendocrine_gland0.57781243
78MP0006276_abnormal_autonomic_nervous0.55477321
79MP0002837_dystrophic_cardiac_calcinosis0.55067660
80MP0001485_abnormal_pinna_reflex0.55059072
81MP0003632_abnormal_nervous_system0.54541317
82MP0004510_myositis0.54114227
83MP0005551_abnormal_eye_electrophysiolog0.48786194
84MP0004215_abnormal_myocardial_fiber0.48366221
85MP0005620_abnormal_muscle_contractility0.48118775
86MP0001943_abnormal_respiration0.46573097
87MP0004145_abnormal_muscle_electrophysio0.45437653
88MP0003956_abnormal_body_size0.44225406
89MP0004484_altered_response_of0.43725391
90MP0001963_abnormal_hearing_physiology0.43470188
91MP0003303_peritoneal_inflammation0.42599419
92MP0001765_abnormal_ion_homeostasis0.41893100
93MP0004742_abnormal_vestibular_system0.41870339
94MP0004043_abnormal_pH_regulation0.41734057
95MP0005623_abnormal_meninges_morphology0.41482066
96MP0002752_abnormal_somatic_nervous0.39808534
97MP0010769_abnormal_survival0.39524437
98MP0004130_abnormal_muscle_cell0.39331991
99MP0002234_abnormal_pharynx_morphology0.39002715
100MP0004036_abnormal_muscle_relaxation0.38906895

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.38520963
2Focal motor seizures (HP:0011153)7.96179894
3Focal seizures (HP:0007359)5.95485529
4Visual hallucinations (HP:0002367)4.67839788
5Annular pancreas (HP:0001734)4.51028092
6Torticollis (HP:0000473)4.17168757
7Poor eye contact (HP:0000817)4.16112694
8Resting tremor (HP:0002322)4.12931395
9Anxiety (HP:0000739)4.01341852
10Action tremor (HP:0002345)3.96907533
11Epileptic encephalopathy (HP:0200134)3.89300518
12Impaired vibration sensation in the lower limbs (HP:0002166)3.85870651
13Depression (HP:0000716)3.75708597
14Broad-based gait (HP:0002136)3.71665549
15Impaired social interactions (HP:0000735)3.71338608
16Abnormal social behavior (HP:0012433)3.71338608
17Focal dystonia (HP:0004373)3.69179137
18Generalized tonic-clonic seizures (HP:0002069)3.62209872
19Ankle clonus (HP:0011448)3.56824915
20Craniofacial dystonia (HP:0012179)3.52391565
21Absence seizures (HP:0002121)3.50676112
22Ankyloglossia (HP:0010296)3.49979726
23Febrile seizures (HP:0002373)3.47456707
24Dysdiadochokinesis (HP:0002075)3.40268591
25Dialeptic seizures (HP:0011146)3.35568177
26Atonic seizures (HP:0010819)3.25079681
27Gaze-evoked nystagmus (HP:0000640)3.21145100
28Urinary bladder sphincter dysfunction (HP:0002839)3.19357281
29Papilledema (HP:0001085)3.16981914
30Dysmetria (HP:0001310)3.15230718
31Stereotypic behavior (HP:0000733)3.11873864
32Postural instability (HP:0002172)3.07005745
33Pointed chin (HP:0000307)3.05691040
34Lower limb amyotrophy (HP:0007210)3.03552887
35Supranuclear gaze palsy (HP:0000605)2.97653691
36Amblyopia (HP:0000646)2.91443169
37Urinary urgency (HP:0000012)2.90549408
38Progressive cerebellar ataxia (HP:0002073)2.89747750
39Dysmetric saccades (HP:0000641)2.86150712
40Truncal ataxia (HP:0002078)2.82065928
41Hyperventilation (HP:0002883)2.79515609
42Prolonged QT interval (HP:0001657)2.71392618
43Abnormal eating behavior (HP:0100738)2.66624616
44Intention tremor (HP:0002080)2.66453689
45Scanning speech (HP:0002168)2.65918633
46Polygenic inheritance (HP:0010982)2.65745823
47Abnormality of the lower motor neuron (HP:0002366)2.63838768
48Abnormality of oral frenula (HP:0000190)2.63268471
49Impaired smooth pursuit (HP:0007772)2.62536303
50Bradykinesia (HP:0002067)2.60490787
51Impaired vibratory sensation (HP:0002495)2.60326900
52Abnormal EKG (HP:0003115)2.58692319
53Distal lower limb amyotrophy (HP:0008944)2.53614476
54Spastic gait (HP:0002064)2.52242011
55Megalencephaly (HP:0001355)2.49934427
56Ventricular fibrillation (HP:0001663)2.42412846
57Mutism (HP:0002300)2.41310405
58Neurofibrillary tangles (HP:0002185)2.40372822
59Cerebral inclusion bodies (HP:0100314)2.40371454
60Atrioventricular block (HP:0001678)2.35149324
61Lower limb asymmetry (HP:0100559)2.31995297
62Status epilepticus (HP:0002133)2.28139550
63Incomplete penetrance (HP:0003829)2.23908667
64Progressive inability to walk (HP:0002505)2.23650514
65Hemiparesis (HP:0001269)2.23529043
66Abnormality of ocular smooth pursuit (HP:0000617)2.21939402
67Truncus arteriosus (HP:0001660)2.15116291
68Clonus (HP:0002169)2.13969254
69Heart block (HP:0012722)2.11505958
70Bundle branch block (HP:0011710)2.11364510
71Hemiplegia (HP:0002301)2.10986130
72Obstructive sleep apnea (HP:0002870)2.10883669
73Distal upper limb amyotrophy (HP:0007149)2.09478175
74Upper limb amyotrophy (HP:0009129)2.09478175
75Limb dystonia (HP:0002451)2.07735318
76Excessive salivation (HP:0003781)2.07227714
77Drooling (HP:0002307)2.07227714
78Neuronal loss in central nervous system (HP:0002529)2.06065990
79Lower limb muscle weakness (HP:0007340)2.05235207
80Insidious onset (HP:0003587)2.01057806
81Termporal pattern (HP:0011008)2.01057806
82Insomnia (HP:0100785)1.97103243
83Epileptiform EEG discharges (HP:0011182)1.97020030
84Abnormality of the periventricular white matter (HP:0002518)1.94786945
85Absent speech (HP:0001344)1.90517003
86Abnormal atrioventricular conduction (HP:0005150)1.89872223
87Deep palmar crease (HP:0006191)1.87918842
88EEG with generalized epileptiform discharges (HP:0011198)1.86806469
89Genetic anticipation (HP:0003743)1.85680830
90Limb hypertonia (HP:0002509)1.83159235
91Abnormality of saccadic eye movements (HP:0000570)1.82894624
92Spinal canal stenosis (HP:0003416)1.82235903
93Diplopia (HP:0000651)1.82169349
94Abnormality of binocular vision (HP:0011514)1.82169349
95Deeply set eye (HP:0000490)1.81829716
96Hypsarrhythmia (HP:0002521)1.81777460
97Bowel incontinence (HP:0002607)1.81603903
98Axonal loss (HP:0003447)1.80784652
99Gait ataxia (HP:0002066)1.80706917
100Primary atrial arrhythmia (HP:0001692)1.80548230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.92931919
2NTRK34.08717447
3MAP3K93.75302642
4RIPK43.28402364
5KSR22.82688177
6DAPK22.73585903
7PRKD32.56482616
8CAMKK12.22867479
9MINK12.15196214
10MAP3K132.06402604
11ARAF2.03447680
12FES1.93613073
13MAP3K41.93575106
14NTRK11.88414924
15KSR11.80741803
16PAK61.70489649
17DAPK11.69788236
18NTRK21.66257878
19TAOK11.61254074
20SIK21.60523071
21CDK51.59406360
22MAP2K71.50909419
23MAP3K21.39017082
24TYRO31.38123025
25MARK11.37997730
26RAF11.33673639
27BMPR21.27387521
28TNIK1.24498261
29PRPF4B1.24494425
30MAP2K41.21992713
31STK381.12274831
32CAMKK21.08079609
33MAP3K121.06483548
34PINK11.06098654
35PTK2B1.01753583
36MAP3K10.91961808
37STK110.90233679
38PRKCG0.89995884
39PRKCH0.89322073
40GRK50.86621229
41SGK2230.85136222
42SGK4940.85136222
43PDPK10.84167335
44PDK10.83393947
45CDK180.81689207
46CAMK2A0.81674171
47CDK150.80109224
48CAMK10.79613849
49SGK10.79149964
50MARK20.77442230
51CDK140.77042775
52ALK0.76176032
53CAMK2B0.75772109
54UHMK10.74731356
55RET0.74662735
56SGK20.74135918
57TNK20.71984364
58CDK190.70458435
59PLK20.70244712
60CDK11A0.69968435
61SGK30.69920789
62NEK10.67212334
63DMPK0.66893377
64MAP2K10.59526011
65TRIB30.59066215
66PRKD20.55590314
67MAPK130.55513668
68RIPK10.54131356
69FGFR20.54117349
70MOS0.53895123
71DAPK30.52832803
72FYN0.52157525
73PRKCZ0.50946420
74RPS6KA30.50629166
75NEK60.50515418
76MAPK100.46423795
77CAMK40.45811693
78LMTK20.43152210
79BRAF0.41432929
80FGR0.40432783
81BRSK10.38397040
82CASK0.38068909
83PNCK0.34752575
84MAP3K70.34126098
85DYRK1A0.33746942
86CAMK2D0.33619776
87PRKCB0.32524219
88WNK10.31891540
89PAK30.31691263
90CAMK2G0.30967127
91PRKCE0.30544820
92PRKCQ0.29898086
93HCK0.28448533
94MUSK0.26311330
95PRKACG0.26087730
96PRKCA0.25677831
97CSNK1A10.25623238
98PRKACA0.25622149
99FRK0.24696782
100CDC42BPA0.22016193

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.59201643
2Nicotine addiction_Homo sapiens_hsa050333.04860191
3Amphetamine addiction_Homo sapiens_hsa050312.86972674
4Long-term potentiation_Homo sapiens_hsa047202.82148017
5Morphine addiction_Homo sapiens_hsa050322.81734476
6Circadian entrainment_Homo sapiens_hsa047132.79097532
7GABAergic synapse_Homo sapiens_hsa047272.65218938
8Synaptic vesicle cycle_Homo sapiens_hsa047212.61365652
9Glutamatergic synapse_Homo sapiens_hsa047242.57228916
10Cocaine addiction_Homo sapiens_hsa050302.45792005
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43169119
12Dopaminergic synapse_Homo sapiens_hsa047282.38738010
13Salivary secretion_Homo sapiens_hsa049702.22064649
14Cholinergic synapse_Homo sapiens_hsa047252.14630409
15Renin secretion_Homo sapiens_hsa049242.08431931
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95294435
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94413224
18Gastric acid secretion_Homo sapiens_hsa049711.88880139
19Oxytocin signaling pathway_Homo sapiens_hsa049211.82655565
20Calcium signaling pathway_Homo sapiens_hsa040201.77520559
21Insulin secretion_Homo sapiens_hsa049111.76799624
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75366554
23Long-term depression_Homo sapiens_hsa047301.60036035
24Serotonergic synapse_Homo sapiens_hsa047261.58723414
25Gap junction_Homo sapiens_hsa045401.57364200
26GnRH signaling pathway_Homo sapiens_hsa049121.51269852
27Taste transduction_Homo sapiens_hsa047421.49425568
28Nitrogen metabolism_Homo sapiens_hsa009101.48570335
29cAMP signaling pathway_Homo sapiens_hsa040241.42975610
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33088914
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30701127
32Glioma_Homo sapiens_hsa052141.24654235
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15294213
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14032822
35Estrogen signaling pathway_Homo sapiens_hsa049151.08473526
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.07428928
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03139268
38Melanogenesis_Homo sapiens_hsa049161.01579706
39Type II diabetes mellitus_Homo sapiens_hsa049300.98805241
40Phospholipase D signaling pathway_Homo sapiens_hsa040720.94203313
41Oocyte meiosis_Homo sapiens_hsa041140.91213915
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90832255
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90008239
44ErbB signaling pathway_Homo sapiens_hsa040120.88987466
45Non-small cell lung cancer_Homo sapiens_hsa052230.85903438
46Collecting duct acid secretion_Homo sapiens_hsa049660.85799577
47Dorso-ventral axis formation_Homo sapiens_hsa043200.85785448
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85488457
49Cardiac muscle contraction_Homo sapiens_hsa042600.84046235
50VEGF signaling pathway_Homo sapiens_hsa043700.83470793
51Pancreatic secretion_Homo sapiens_hsa049720.83288598
52Axon guidance_Homo sapiens_hsa043600.81129766
53Alcoholism_Homo sapiens_hsa050340.80419611
54Phototransduction_Homo sapiens_hsa047440.80234235
55Dilated cardiomyopathy_Homo sapiens_hsa054140.80179831
56Thyroid hormone synthesis_Homo sapiens_hsa049180.77399756
57Rap1 signaling pathway_Homo sapiens_hsa040150.77169107
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72952711
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72014318
60Choline metabolism in cancer_Homo sapiens_hsa052310.70487298
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69241049
62MAPK signaling pathway_Homo sapiens_hsa040100.66689920
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65174866
64Type I diabetes mellitus_Homo sapiens_hsa049400.64249046
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.63796650
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63305597
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.59755684
68mTOR signaling pathway_Homo sapiens_hsa041500.58302500
69Glucagon signaling pathway_Homo sapiens_hsa049220.57195479
70Chemokine signaling pathway_Homo sapiens_hsa040620.56921743
71Ras signaling pathway_Homo sapiens_hsa040140.56178408
72African trypanosomiasis_Homo sapiens_hsa051430.54929208
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54394587
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53797351
75Bile secretion_Homo sapiens_hsa049760.51503081
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50221016
77Platelet activation_Homo sapiens_hsa046110.48185797
78Vibrio cholerae infection_Homo sapiens_hsa051100.47640650
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47185423
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46162142
81Endocytosis_Homo sapiens_hsa041440.45661988
82Prion diseases_Homo sapiens_hsa050200.44779134
83Inositol phosphate metabolism_Homo sapiens_hsa005620.43065581
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42216369
85Endometrial cancer_Homo sapiens_hsa052130.41000060
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39564389
87Ovarian steroidogenesis_Homo sapiens_hsa049130.37791245
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37580062
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37380007
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36939366
91Renal cell carcinoma_Homo sapiens_hsa052110.35157713
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31744282
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31467241
94Insulin signaling pathway_Homo sapiens_hsa049100.30089111
95Circadian rhythm_Homo sapiens_hsa047100.27920170
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27260244
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26059225
98Wnt signaling pathway_Homo sapiens_hsa043100.25440770
99Thyroid cancer_Homo sapiens_hsa052160.25248162
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25082537

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