ANKRD65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.91321670
2cilium movement (GO:0003341)8.26423618
3epithelial cilium movement (GO:0003351)7.25996394
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.16987188
5motile cilium assembly (GO:0044458)7.15249386
6axoneme assembly (GO:0035082)6.61708210
7cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.52982360
8limb bud formation (GO:0060174)5.08769055
9endothelial cell morphogenesis (GO:0001886)4.97077955
10surfactant homeostasis (GO:0043129)4.96765559
11regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.86720544
12axon ensheathment in central nervous system (GO:0032291)4.85529940
13central nervous system myelination (GO:0022010)4.85529940
14fatty acid elongation (GO:0030497)4.84000092
15left/right pattern formation (GO:0060972)4.79369327
16primary alcohol catabolic process (GO:0034310)4.76173619
17chondrocyte development (GO:0002063)4.74902491
18regulation of cilium movement (GO:0003352)4.73187766
19negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.57416283
20response to nitrosative stress (GO:0051409)4.45847099
21nucleotide transmembrane transport (GO:1901679)4.38965365
22microtubule bundle formation (GO:0001578)4.37315182
23long-chain fatty acid biosynthetic process (GO:0042759)4.36989669
24sphingomyelin metabolic process (GO:0006684)4.34149616
25one-carbon compound transport (GO:0019755)4.31436344
26xenobiotic catabolic process (GO:0042178)4.20761987
27lung epithelium development (GO:0060428)4.19899506
28cell aggregation (GO:0098743)4.16311907
29cartilage condensation (GO:0001502)4.16311907
30regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.05946634
31positive regulation of endothelial cell differentiation (GO:0045603)3.96640592
32intraciliary transport (GO:0042073)3.94487508
33chemical homeostasis within a tissue (GO:0048875)3.83847731
34vitamin transmembrane transport (GO:0035461)3.82809962
35glutathione derivative metabolic process (GO:1901685)3.81593642
36glutathione derivative biosynthetic process (GO:1901687)3.81593642
37purine ribonucleotide transport (GO:0015868)3.77903174
38ethanol oxidation (GO:0006069)3.70634044
39adenine nucleotide transport (GO:0051503)3.69636051
40response to hyperoxia (GO:0055093)3.68281092
41response to increased oxygen levels (GO:0036296)3.68281092
42regulation of response to osmotic stress (GO:0047484)3.66564605
43import into cell (GO:0098657)3.64692149
44response to vitamin A (GO:0033189)3.59205065
45left/right axis specification (GO:0070986)3.58796555
46mesenchymal cell proliferation (GO:0010463)3.56090748
47cilium organization (GO:0044782)3.55473696
48cilium assembly (GO:0042384)3.49083711
49regulation of microtubule-based movement (GO:0060632)3.48734829
50purine nucleotide transport (GO:0015865)3.43935151
51positive regulation of cartilage development (GO:0061036)3.41394925
52sodium-independent organic anion transport (GO:0043252)3.40676779
53synaptic vesicle maturation (GO:0016188)3.39533858
54negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.38290542
55synaptic vesicle docking involved in exocytosis (GO:0016081)3.37142717
56glutamate secretion (GO:0014047)3.37124555
57protein localization to cilium (GO:0061512)3.36134666
58ventricular system development (GO:0021591)3.34964958
59SMAD protein signal transduction (GO:0060395)3.33723972
60lateral sprouting from an epithelium (GO:0060601)3.29092962
61adenosine metabolic process (GO:0046085)3.24342903
62organic cation transport (GO:0015695)3.23371984
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.21703236
64regulation of collateral sprouting (GO:0048670)3.20602569
65fat-soluble vitamin biosynthetic process (GO:0042362)3.13982903
66endochondral ossification (GO:0001958)3.12438714
67replacement ossification (GO:0036075)3.12438714
68negative regulation of humoral immune response (GO:0002921)3.12119361
69diterpenoid biosynthetic process (GO:0016102)3.10489997
70cartilage development (GO:0051216)3.02209192
71regulation of integrin-mediated signaling pathway (GO:2001044)3.01353164
72embryonic skeletal joint morphogenesis (GO:0060272)3.00350452
73branching involved in salivary gland morphogenesis (GO:0060445)3.00101358
74regulation of steroid hormone biosynthetic process (GO:0090030)2.99763265
75adhesion of symbiont to host cell (GO:0044650)2.99567080
76virion attachment to host cell (GO:0019062)2.99567080
77synaptic vesicle exocytosis (GO:0016079)2.97993621
78sperm capacitation (GO:0048240)2.96512578
79cellular component assembly involved in morphogenesis (GO:0010927)2.96505687
80regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95924903
81neurotransmitter secretion (GO:0007269)2.91790426
82regulation of endothelial cell differentiation (GO:0045601)2.89667982
83sodium ion homeostasis (GO:0055078)2.89572515
84myelination (GO:0042552)2.88908726
85ensheathment of neurons (GO:0007272)2.87506707
86axon ensheathment (GO:0008366)2.87506707
87cell proliferation involved in kidney development (GO:0072111)2.87478535
88positive regulation of chondrocyte differentiation (GO:0032332)2.85125096
89regulation of autophagic vacuole assembly (GO:2000785)2.81876139
90retinol metabolic process (GO:0042572)2.79652993
91negative regulation of axon extension involved in axon guidance (GO:0048843)2.79527987
92bone trabecula formation (GO:0060346)2.77294495
93cytoplasmic microtubule organization (GO:0031122)2.76324599
94microtubule-based movement (GO:0007018)2.75638633
95regulation of type B pancreatic cell apoptotic process (GO:2000674)2.74733943
96response to dietary excess (GO:0002021)2.74539913
97regulation of synaptic vesicle exocytosis (GO:2000300)2.73238928
98positive regulation of synapse maturation (GO:0090129)2.70885580
99chondroitin sulfate biosynthetic process (GO:0030206)2.70658493
100calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.69025369
101embryonic viscerocranium morphogenesis (GO:0048703)2.68616683
102multicellular organismal water homeostasis (GO:0050891)2.68184035
103adhesion of symbiont to host (GO:0044406)2.67977025
104L-ascorbic acid metabolic process (GO:0019852)2.67308469
105negative regulation of immunoglobulin mediated immune response (GO:0002890)2.67134054
106negative regulation of B cell mediated immunity (GO:0002713)2.67134054
107keratan sulfate catabolic process (GO:0042340)2.66581507
108response to vitamin D (GO:0033280)2.66112825
109chemosensory behavior (GO:0007635)2.65908401
110response to xenobiotic stimulus (GO:0009410)2.65379938
111potassium ion homeostasis (GO:0055075)2.65131160
112negative regulation of neurotransmitter secretion (GO:0046929)2.62599674
113positive regulation of p38MAPK cascade (GO:1900745)2.61079335
114establishment of apical/basal cell polarity (GO:0035089)2.59402704
115cell projection assembly (GO:0030031)2.58737569
116primary alcohol metabolic process (GO:0034308)2.58680089
117cilium morphogenesis (GO:0060271)2.57824481
118cellular response to prostaglandin stimulus (GO:0071379)2.57561364
119myelin maintenance (GO:0043217)2.57403796
120glutathione biosynthetic process (GO:0006750)2.56664376
121NADP metabolic process (GO:0006739)2.56642818
122drug transmembrane transport (GO:0006855)2.56602861
123glycosphingolipid biosynthetic process (GO:0006688)2.55122303
124short-chain fatty acid metabolic process (GO:0046459)2.55050372
125glutathione metabolic process (GO:0006749)2.52749197
126ethanol metabolic process (GO:0006067)2.52607482
127skeletal system development (GO:0001501)2.52275018
128embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51821146
129chondrocyte proliferation (GO:0035988)2.51673546
130positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.50028906
131terpenoid biosynthetic process (GO:0016114)2.49456514
132regulation of vasculogenesis (GO:2001212)2.49397254
133cellular ketone body metabolic process (GO:0046950)2.49130930
134establishment or maintenance of monopolar cell polarity (GO:0061339)2.49066941
135establishment of monopolar cell polarity (GO:0061162)2.49066941
136lung-associated mesenchyme development (GO:0060484)2.48768029
137nucleoside diphosphate phosphorylation (GO:0006165)2.48722270
138mesenchyme morphogenesis (GO:0072132)2.48012725
139brain morphogenesis (GO:0048854)2.46049640
140pyrimidine-containing compound transmembrane transport (GO:0072531)2.46045965
141negative regulation of gluconeogenesis (GO:0045721)2.44907861
142regulation of neurotransmitter levels (GO:0001505)2.44384324
143negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.44358626
144nonribosomal peptide biosynthetic process (GO:0019184)2.43911759
145renal absorption (GO:0070293)2.42210061
146cellular hyperosmotic response (GO:0071474)2.42199447
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.41995668
148cellular response to nitric oxide (GO:0071732)2.41828721
149positive regulation of actin filament depolymerization (GO:0030836)2.41079135
150cholesterol biosynthetic process (GO:0006695)2.40683808
151proteoglycan metabolic process (GO:0006029)2.39942281
152neuronal ion channel clustering (GO:0045161)2.39666159
153positive regulation of alcohol biosynthetic process (GO:1902932)2.39501441
154positive regulation of catenin import into nucleus (GO:0035413)2.39303665
155asymmetric protein localization (GO:0008105)2.39171320
156regulation of vacuole organization (GO:0044088)2.38518030
157L-phenylalanine catabolic process (GO:0006559)2.38262040
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.38262040
159positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.38133040
160positive regulation of hormone biosynthetic process (GO:0046886)2.37136827
161regulation of interleukin-5 production (GO:0032674)2.36692833
162nucleotide transport (GO:0006862)2.36022765
163phosphatidylcholine biosynthetic process (GO:0006656)2.35474302
164neurotransmitter catabolic process (GO:0042135)2.35359494
165linoleic acid metabolic process (GO:0043651)2.35343450
166water homeostasis (GO:0030104)2.35187740
167collagen fibril organization (GO:0030199)2.34997651
168very long-chain fatty acid metabolic process (GO:0000038)2.34620168
169apical protein localization (GO:0045176)2.34474077
170response to redox state (GO:0051775)2.34295215
171epithelial cell morphogenesis (GO:0003382)2.34177964
172detection of calcium ion (GO:0005513)2.34134934
173cellular sodium ion homeostasis (GO:0006883)2.32811480
174connective tissue development (GO:0061448)2.32138996
175regulation of neuronal synaptic plasticity (GO:0048168)2.31901178
176regulation of synapse maturation (GO:0090128)2.31090074
177regulation of synaptic vesicle transport (GO:1902803)2.30743599
178lung lobe morphogenesis (GO:0060463)2.30535117
179aldehyde catabolic process (GO:0046185)2.30114199
180negative regulation of inclusion body assembly (GO:0090084)2.29935768
181positive regulation of neurotransmitter transport (GO:0051590)2.28405994
182neurotransmitter biosynthetic process (GO:0042136)2.24739639
183dendritic spine morphogenesis (GO:0060997)2.23724477
184epithelial cell fate commitment (GO:0072148)2.23607827
185glomerular epithelial cell development (GO:0072310)2.23441661
186cerebellar granule cell differentiation (GO:0021707)2.23397578
187L-phenylalanine metabolic process (GO:0006558)2.23070506
188erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.23070506
189neurotransmitter transport (GO:0006836)2.21514594
190negative regulation of T cell differentiation in thymus (GO:0033085)2.21241349
191regulation of vesicle fusion (GO:0031338)2.20698682
192axonemal dynein complex assembly (GO:0070286)11.0452367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.02457024
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.13043347
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.21363067
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.74507791
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56768603
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34947904
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27040948
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.24879347
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24652326
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01423003
11EZH2_27304074_Chip-Seq_ESCs_Mouse1.99683779
12AR_21572438_ChIP-Seq_LNCaP_Human1.96990543
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.96331783
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93405792
15REST_21632747_ChIP-Seq_MESCs_Mouse1.92309617
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85000308
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83698724
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83698724
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81970421
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78574194
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73604822
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.69622840
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68856619
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67409138
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65629679
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.63389135
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61625056
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60895100
29CLOCK_20551151_ChIP-Seq_293T_Human1.57800643
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53869679
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53869679
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53869679
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51631851
34CTCF_27219007_Chip-Seq_Bcells_Human1.51558499
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49573189
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.49328112
37TAF15_26573619_Chip-Seq_HEK293_Human1.46968710
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46533027
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.45650463
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.44492293
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42739431
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42452876
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41974171
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.41666113
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40842054
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.40099210
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39703578
48SOX2_20726797_ChIP-Seq_SW620_Human1.39668614
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38776454
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38593446
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37441823
52DROSHA_22980978_ChIP-Seq_HELA_Human1.37342586
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.36845416
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35829889
55EZH2_22144423_ChIP-Seq_EOC_Human1.35476933
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31226262
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28536390
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28536390
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28442350
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28113330
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27841954
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27637109
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26980878
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26961671
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25477142
66ZNF274_21170338_ChIP-Seq_K562_Hela1.24379058
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22887946
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22524823
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.21694784
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.21673237
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20286770
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20200495
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20170532
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20123379
75TP53_18474530_ChIP-ChIP_U2OS_Human1.18136597
76SMC4_20622854_ChIP-Seq_HELA_Human1.17392432
77VDR_22108803_ChIP-Seq_LS180_Human1.16404854
78FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14414966
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14046023
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10361841
81LXR_22158963_ChIP-Seq_LIVER_Mouse1.09940294
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09720797
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08987135
84TET1_21490601_ChIP-Seq_MESCs_Mouse1.08330591
85CJUN_26792858_Chip-Seq_BT549_Human1.07446114
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06735695
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05538236
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.04896919
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04771830
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04437865
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03470169
92TP63_22573176_ChIP-Seq_HFKS_Human1.02788128
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.02231109
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01690621
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01463317
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.01319048
97AHR_22903824_ChIP-Seq_MCF-7_Human1.00677198
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00461190
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00275900
100SMAD4_21799915_ChIP-Seq_A2780_Human0.99800272
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98931272
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.98748896
103BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98444713
104GBX2_23144817_ChIP-Seq_PC3_Human0.98034420
105CREB1_26743006_Chip-Seq_LNCaP_Human0.97702759
106SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96906100
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96432677
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.96341368
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.95788323
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95747169
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95585695
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95510819
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95317921
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94584590
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94120069
116LXR_22292898_ChIP-Seq_THP-1_Human0.94056062
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94046473
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93614805
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93404484
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93233518
121EP300_21415370_ChIP-Seq_HL-1_Mouse0.92670189
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92418439
123RXR_22108803_ChIP-Seq_LS180_Human0.92230695
124P68_20966046_ChIP-Seq_HELA_Human0.91353935
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91203556
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.91033172
127RING1B_27294783_Chip-Seq_ESCs_Mouse0.90797562
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89321504
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88960120
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88926736
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.87105596
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.87105596
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87046171
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86720751
135MYC_19829295_ChIP-Seq_ESCs_Human0.86646993
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86519090
137SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86515703
138VDR_24787735_ChIP-Seq_THP-1_Human0.86144743
139CTCF_20526341_ChIP-Seq_ESCs_Human0.86059749
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86047662
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85888939
142GF1_26923725_Chip-Seq_HPCs_Mouse0.85715917
143GATA1_19941826_ChIP-Seq_K562_Human0.85672796
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84219685
145AR_19668381_ChIP-Seq_PC3_Human0.83812322
146KLF5_25053715_ChIP-Seq_YYC3_Human0.83001661
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.81409196
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81172123
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80769818
150STAT1_20625510_ChIP-Seq_HELA_Human0.80567364
151CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80348091
152OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80297414
153TP63_23658742_ChIP-Seq_EP156T_Human0.80155263
154RUNX1_27514584_Chip-Seq_MCF-7_Human0.78836640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.65870465
2MP0009250_abnormal_appendicular_skeleto3.44971218
3MP0004782_abnormal_surfactant_physiolog3.42971249
4MP0001984_abnormal_olfaction3.01672164
5MP0004134_abnormal_chest_morphology2.99999916
6MP0008875_abnormal_xenobiotic_pharmacok2.99434980
7MP0001958_emphysema2.84220415
8MP0003880_abnormal_central_pattern2.79026323
9MP0008438_abnormal_cutaneous_collagen2.63174835
10MP0004270_analgesia2.60891179
11MP0004859_abnormal_synaptic_plasticity2.59725926
12MP0002653_abnormal_ependyma_morphology2.59100472
13MP0000163_abnormal_cartilage_morphology2.50614057
14MP0002909_abnormal_adrenal_gland2.48929738
15MP0000762_abnormal_tongue_morphology2.41722490
16MP0002139_abnormal_hepatobiliary_system2.34924959
17MP0002138_abnormal_hepatobiliary_system2.30321286
18MP0003879_abnormal_hair_cell2.26447357
19MP0002876_abnormal_thyroid_physiology2.25327516
20MP0003941_abnormal_skin_development2.16340734
21MP0004043_abnormal_pH_regulation2.13808342
22MP0009046_muscle_twitch2.12452553
23MP0003122_maternal_imprinting2.11047682
24MP0002933_joint_inflammation2.06999105
25MP0002115_abnormal_skeleton_extremities2.04935850
26MP0005083_abnormal_biliary_tract2.04125287
27MP0002272_abnormal_nervous_system2.03702724
28MP0002896_abnormal_bone_mineralization2.02456405
29MP0004272_abnormal_basement_membrane2.01246539
30MP0005503_abnormal_tendon_morphology1.97551220
31MP0004019_abnormal_vitamin_homeostasis1.95806854
32MP0004133_heterotaxia1.94632664
33MP0002822_catalepsy1.90850059
34MP0002734_abnormal_mechanical_nocicepti1.90600532
35MP0001299_abnormal_eye_distance/1.88004950
36MP0008260_abnormal_autophagy1.87707360
37MP0002064_seizures1.87435396
38MP0003646_muscle_fatigue1.87024403
39MP0002282_abnormal_trachea_morphology1.86604899
40MP0009745_abnormal_behavioral_response1.82656562
41MP0001502_abnormal_circadian_rhythm1.82385903
42MP0005646_abnormal_pituitary_gland1.82352518
43MP0003635_abnormal_synaptic_transmissio1.80046541
44MP0010030_abnormal_orbit_morphology1.79685656
45MP0009780_abnormal_chondrocyte_physiolo1.78381034
46MP0001177_atelectasis1.77374456
47MP0001346_abnormal_lacrimal_gland1.72221395
48MP0002572_abnormal_emotion/affect_behav1.68600328
49MP0008789_abnormal_olfactory_epithelium1.66327866
50MP0001486_abnormal_startle_reflex1.65616692
51MP0000920_abnormal_myelination1.65509410
52MP0005508_abnormal_skeleton_morphology1.65366697
53MP0004147_increased_porphyrin_level1.63880053
54MP0003690_abnormal_glial_cell1.61493495
55MP0003937_abnormal_limbs/digits/tail_de1.59499470
56MP0002113_abnormal_skeleton_development1.57322686
57MP0002063_abnormal_learning/memory/cond1.57134340
58MP0002089_abnormal_postnatal_growth/wei1.56711965
59MP0002233_abnormal_nose_morphology1.54886419
60MP0003136_yellow_coat_color1.54495204
61MP0005388_respiratory_system_phenotype1.52319701
62MP0002133_abnormal_respiratory_system1.52319701
63MP0002109_abnormal_limb_morphology1.50131737
64MP0003787_abnormal_imprinting1.48936650
65MP0003195_calcinosis1.46107229
66MP0005220_abnormal_exocrine_pancreas1.45351251
67MP0001765_abnormal_ion_homeostasis1.44995784
68MP0002557_abnormal_social/conspecific_i1.43296568
69MP0001501_abnormal_sleep_pattern1.42692187
70MP0001944_abnormal_pancreas_morphology1.40110756
71MP0008995_early_reproductive_senescence1.39945828
72MP0008961_abnormal_basal_metabolism1.39426083
73MP0003950_abnormal_plasma_membrane1.38459141
74MP0001970_abnormal_pain_threshold1.38015328
75MP0005551_abnormal_eye_electrophysiolog1.37393330
76MP0005423_abnormal_somatic_nervous1.37340072
77MP0010386_abnormal_urinary_bladder1.36130260
78MP0005394_taste/olfaction_phenotype1.36126263
79MP0005499_abnormal_olfactory_system1.36126263
80MP0009379_abnormal_foot_pigmentation1.36030281
81MP0002254_reproductive_system_inflammat1.35413723
82MP0000579_abnormal_nail_morphology1.34214849
83MP0005164_abnormal_response_to1.32908484
84MP0001270_distended_abdomen1.30364191
85MP0010678_abnormal_skin_adnexa1.28962463
86MP0006276_abnormal_autonomic_nervous1.28660357
87MP0004185_abnormal_adipocyte_glucose1.28336427
88MP0000013_abnormal_adipose_tissue1.27328598
89MP0002295_abnormal_pulmonary_circulatio1.27065795
90MP0002638_abnormal_pupillary_reflex1.27045368
91MP0000383_abnormal_hair_follicle1.26312427
92MP0010329_abnormal_lipoprotein_level1.25505514
93MP0003385_abnormal_body_wall1.24447001
94MP0004381_abnormal_hair_follicle1.22746323
95MP0002796_impaired_skin_barrier1.22562752
96MP0002132_abnormal_respiratory_system1.22119325
97MP0003633_abnormal_nervous_system1.20823718
98MP0000751_myopathy1.18749828
99MP0001756_abnormal_urination1.18698027
100MP0004885_abnormal_endolymph1.17586337
101MP0003938_abnormal_ear_development1.17324044
102MP0005365_abnormal_bile_salt1.17045752
103MP0000639_abnormal_adrenal_gland1.13741672
104MP0005595_abnormal_vascular_smooth1.12989600
105MP0003283_abnormal_digestive_organ1.12766754
106MP0002735_abnormal_chemical_nociception1.10954929
107MP0000537_abnormal_urethra_morphology1.09964418
108MP0001905_abnormal_dopamine_level1.09450964
109MP0002998_abnormal_bone_remodeling1.09424964
110MP0002229_neurodegeneration1.09053441
111MP0001485_abnormal_pinna_reflex1.07985185
112MP0005636_abnormal_mineral_homeostasis1.07983658
113MP0005085_abnormal_gallbladder_physiolo1.07485889
114MP0005390_skeleton_phenotype1.06660466
115MP0005645_abnormal_hypothalamus_physiol1.06480189
116MP0002733_abnormal_thermal_nociception1.06404951
117MP0003123_paternal_imprinting1.06389642
118MP0005360_urolithiasis1.05383126
119MP0002098_abnormal_vibrissa_morphology1.04114177
120MP0002932_abnormal_joint_morphology1.03610736
121MP0005623_abnormal_meninges_morphology1.03330803
122MP0003329_amyloid_beta_deposits1.01155531
123MP0010368_abnormal_lymphatic_system1.00745817
124MP0002168_other_aberrant_phenotype0.99516452
125MP0001968_abnormal_touch/_nociception0.99039488
126MP0005058_abnormal_lysosome_morphology0.98689677
127MP0001533_abnormal_skeleton_physiology0.98212705
128MP0004742_abnormal_vestibular_system0.95708664
129MP0000534_abnormal_ureter_morphology0.95148309
130MP0003755_abnormal_palate_morphology0.94663634
131MP0003795_abnormal_bone_structure0.92546171
132MP0004883_abnormal_blood_vessel0.92109407
133MP0000678_abnormal_parathyroid_gland0.91449152
134MP0000955_abnormal_spinal_cord0.89417790
135MP0003631_nervous_system_phenotype0.88551977
136MP0003656_abnormal_erythrocyte_physiolo0.87772831
137MP0002069_abnormal_eating/drinking_beha0.86651052
138MP0002882_abnormal_neuron_morphology0.86526400
139MP0002111_abnormal_tail_morphology0.86475481
140MP0010234_abnormal_vibrissa_follicle0.85710961
141MP0002078_abnormal_glucose_homeostasis0.85657156
142MP0001661_extended_life_span0.84862782
143MP0003878_abnormal_ear_physiology0.84765639
144MP0005377_hearing/vestibular/ear_phenot0.84765639
145MP0005332_abnormal_amino_acid0.84653295
146MP0005386_behavior/neurological_phenoty0.84621358
147MP0004924_abnormal_behavior0.84621358
148MP0003453_abnormal_keratinocyte_physiol0.83724984
149MP0002116_abnormal_craniofacial_bone0.83251891
150MP0005253_abnormal_eye_physiology0.83177705
151MP0002693_abnormal_pancreas_physiology0.83144822
152MP0009643_abnormal_urine_homeostasis0.82840219
153MP0001963_abnormal_hearing_physiology0.82509253
154MP0002060_abnormal_skin_morphology0.82123729
155MP0002066_abnormal_motor_capabilities/c0.81662092
156MP0005409_darkened_coat_color0.81302738
157MP0000631_abnormal_neuroendocrine_gland0.80605385
158MP0005023_abnormal_wound_healing0.80251920
159MP0001340_abnormal_eyelid_morphology0.79979357
160MP0001666_abnormal_nutrient_absorption0.79954644
161MP0003953_abnormal_hormone_level0.79132581
162MP0001664_abnormal_digestion0.78450499
163MP0006072_abnormal_retinal_apoptosis0.77882063
164MP0000681_abnormal_thyroid_gland0.77642840
165MP0003075_altered_response_to0.77556703
166MP0002118_abnormal_lipid_homeostasis0.76865477
167MP0005379_endocrine/exocrine_gland_phen0.75472866
168MP0004811_abnormal_neuron_physiology0.75338343
169MP0002184_abnormal_innervation0.75047038
170MP0001849_ear_inflammation0.74700935
171MP0000462_abnormal_digestive_system0.74426766
172MP0002277_abnormal_respiratory_mucosa0.74274854
173MP0005448_abnormal_energy_balance0.72693019

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.85190632
2Abnormal respiratory motile cilium morphology (HP:0005938)8.85190632
3Abnormal respiratory motile cilium physiology (HP:0012261)8.57142467
4Abnormal ciliary motility (HP:0012262)8.34356127
5Dynein arm defect of respiratory motile cilia (HP:0012255)8.34022581
6Absent/shortened dynein arms (HP:0200106)8.34022581
7Small epiphyses (HP:0010585)7.20541744
8Epiphyseal dysplasia (HP:0002656)6.93256653
9Irregular epiphyses (HP:0010582)6.86643475
10Delayed epiphyseal ossification (HP:0002663)6.52060341
11Chronic bronchitis (HP:0004469)6.28493123
12Bronchiectasis (HP:0002110)5.67751205
13Nasal polyposis (HP:0100582)4.90948904
14Metaphyseal cupping (HP:0003021)4.68724593
15Abnormal tarsal ossification (HP:0008369)4.66148713
16Flat capital femoral epiphysis (HP:0003370)4.51892219
17Genu varum (HP:0002970)4.42408222
18Metaphyseal irregularity (HP:0003025)4.10300652
19Abnormality of the nasal mucosa (HP:0000433)4.02557263
20Absent epiphyses (HP:0010577)3.83300008
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.83300008
22Cupped ribs (HP:0000887)3.82846895
23Abnormality of the phalanges of the 2nd finger (HP:0009541)3.81031335
24Vitreoretinal degeneration (HP:0000655)3.78783666
25Spinal cord compression (HP:0002176)3.70319423
26Hypoplastic ischia (HP:0003175)3.64649563
27Abnormality of femoral epiphyses (HP:0006499)3.59814095
28Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.59814095
29Abnormality of the epiphysis of the femoral head (HP:0010574)3.59198830
30Irregular vertebral endplates (HP:0003301)3.57379860
31Flat acetabular roof (HP:0003180)3.53351247
32Mild short stature (HP:0003502)3.46679413
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.44919211
34Infertility (HP:0000789)3.44043820
35Abnormal foot bone ossification (HP:0010675)3.28621336
36Limited hip movement (HP:0008800)3.27651881
37Osteoarthritis (HP:0002758)3.23983171
38Abnormality of the vertebral endplates (HP:0005106)3.23874441
39Carpal bone hypoplasia (HP:0001498)3.23293423
40Abnormality of the ischium (HP:0003174)3.20741315
41Abnormality of the femoral head (HP:0003368)3.17982539
42Short femoral neck (HP:0100864)3.14673503
43Limited elbow extension (HP:0001377)3.13158014
44Abnormality of the 2nd finger (HP:0004100)2.99408756
45Bronchitis (HP:0012387)2.98783022
46Male infertility (HP:0003251)2.96504200
47Occipital encephalocele (HP:0002085)2.96364077
48Chronic sinusitis (HP:0011109)2.93322618
49Recurrent sinusitis (HP:0011108)2.93077332
50Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.88827097
51Beaking of vertebral bodies (HP:0004568)2.88491076
52Metaphyseal dysplasia (HP:0100255)2.87513759
53Ulnar bowing (HP:0003031)2.84624214
54Mesomelia (HP:0003027)2.84355915
55Recurrent otitis media (HP:0000403)2.82777665
56Abnormality of the middle phalanges of the toes (HP:0010183)2.70701055
57Decreased circulating renin level (HP:0003351)2.70440997
58Pancreatic fibrosis (HP:0100732)2.69048652
59Relative macrocephaly (HP:0004482)2.68141660
60Abnormality of carpal bone ossification (HP:0006257)2.66840977
61True hermaphroditism (HP:0010459)2.63801348
62Hip contracture (HP:0003273)2.61993614
63Atelectasis (HP:0100750)2.60857699
64Nephronophthisis (HP:0000090)2.58303983
65Cystic liver disease (HP:0006706)2.54667087
66Tubulointerstitial nephritis (HP:0001970)2.53356493
67Mixed hearing impairment (HP:0000410)2.49615040
68Arthropathy (HP:0003040)2.46873841
69Myokymia (HP:0002411)2.43369118
70Ovoid vertebral bodies (HP:0003300)2.43180929
71Hyperkalemia (HP:0002153)2.42279755
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42199525
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41873877
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.41873877
75Hypoplastic pelvis (HP:0008839)2.41538364
76Fetal akinesia sequence (HP:0001989)2.38901874
77Abnormality of renin-angiotensin system (HP:0000847)2.34267463
78Barrel-shaped chest (HP:0001552)2.33315938
79Abnormality of midbrain morphology (HP:0002418)2.32390438
80Molar tooth sign on MRI (HP:0002419)2.32390438
81Gout (HP:0001997)2.31410624
82Lumbar hyperlordosis (HP:0002938)2.31243778
83Neonatal short-limb short stature (HP:0008921)2.29680450
84Chronic hepatic failure (HP:0100626)2.29539622
85Chronic otitis media (HP:0000389)2.29013533
86Aplasia/hypoplasia of the femur (HP:0005613)2.28682657
87Femoral bowing (HP:0002980)2.27542221
88Vertebral clefting (HP:0008428)2.27066993
89Flared metaphyses (HP:0003015)2.26014073
90Short middle phalanx of finger (HP:0005819)2.24991490
91Hyperaldosteronism (HP:0000859)2.23954598
92Hypoplasia of the odontoid process (HP:0003311)2.23255705
93Tubulointerstitial fibrosis (HP:0005576)2.22371872
94Thoracolumbar scoliosis (HP:0002944)2.21377531
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20633461
96Pancreatic cysts (HP:0001737)2.20108042
97Waddling gait (HP:0002515)2.19789004
98Protuberant abdomen (HP:0001538)2.19626539
99Flattened epiphyses (HP:0003071)2.18029647
100Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.16363463
101Obstructive sleep apnea (HP:0002870)2.16078211
102Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15229292
103Abnormal hand bone ossification (HP:0010660)2.13619907
104Rhinitis (HP:0012384)2.13517720
105Abnormal ossification of hand bones (HP:0005921)2.11405493
106Enlarged epiphyses (HP:0010580)2.10006258
107Interstitial pulmonary disease (HP:0006530)2.10002986
108Renal salt wasting (HP:0000127)2.09948130
109Abnormality of the pubic bones (HP:0003172)2.09785806
110Hand muscle atrophy (HP:0009130)2.09540298
111Platyspondyly (HP:0000926)2.07420653
112Abnormality of the renal medulla (HP:0100957)2.07222376
113Ulnar deviation of the wrist (HP:0003049)2.07153657
114Medial flaring of the eyebrow (HP:0010747)2.06990733
115Abnormal vertebral ossification (HP:0100569)2.06207814
116Hypokalemic alkalosis (HP:0001949)2.05473552
117Gait imbalance (HP:0002141)2.04475994
118Abnormality of calcium-phosphate metabolism (HP:0100530)2.03550080
119Sleep apnea (HP:0010535)2.03141114
120Alacrima (HP:0000522)2.02793298
121Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.00214389
122Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97833923
123Abnormality of the proximal phalanges of the hand (HP:0009834)1.97421727
124Coxa vara (HP:0002812)1.96918970
125Neurofibrillary tangles (HP:0002185)1.94172815
126Humeroradial synostosis (HP:0003041)1.93586838
127Synostosis involving the elbow (HP:0003938)1.93586838
128Epileptic encephalopathy (HP:0200134)1.92148227
129Torticollis (HP:0000473)1.92065823
130Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.89963897
131Postaxial foot polydactyly (HP:0001830)1.88750476
132Increased circulating renin level (HP:0000848)1.87543000
133Congenital primary aphakia (HP:0007707)1.87108437
134Bowed forearm bones (HP:0003956)1.86529106
135Bowing of the arm (HP:0006488)1.86529106
136Popliteal pterygium (HP:0009756)1.85944008
137Stillbirth (HP:0003826)1.85683072
138Bell-shaped thorax (HP:0001591)1.85209784
139Tubular atrophy (HP:0000092)1.84034500
140Abnormality of the middle phalanges of the hand (HP:0009833)1.81825904
141Stridor (HP:0010307)1.81814026
142Abnormality of the odontoid process (HP:0003310)1.81594095
143Aplasia involving bones of the upper limbs (HP:0009823)1.81111332
144Aplasia of the phalanges of the hand (HP:0009802)1.81111332
145Aplasia involving bones of the extremities (HP:0009825)1.81111332
146Osteomalacia (HP:0002749)1.79370579
147Thickened helices (HP:0000391)1.79180577
148Hyperinsulinemic hypoglycemia (HP:0000825)1.78650522
149Hyperactive renin-angiotensin system (HP:0000841)1.78368888
150Hypoglycemic seizures (HP:0002173)1.77054872
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76436309
152Abnormality of chloride homeostasis (HP:0011422)1.71266521
153Abnormality of permanent molar morphology (HP:0011071)1.68804013
154Abnormality of the dental root (HP:0006486)1.68804013
155Taurodontia (HP:0000679)1.68804013
156Congenital hepatic fibrosis (HP:0002612)1.66834614
157Nephrogenic diabetes insipidus (HP:0009806)1.65619976
158Focal dystonia (HP:0004373)1.64517623
159Febrile seizures (HP:0002373)1.63894414
160Insulin-resistant diabetes mellitus (HP:0000831)1.63498051
161Growth hormone excess (HP:0000845)1.61545962
162Ventricular fibrillation (HP:0001663)1.60518339
163Abnormality of molar (HP:0011077)1.58486107
164Abnormality of molar morphology (HP:0011070)1.58486107
165Focal seizures (HP:0007359)1.57693901
166Male pseudohermaphroditism (HP:0000037)1.57689390
167Adrenal overactivity (HP:0002717)1.57539422
168Ankle clonus (HP:0011448)1.56091976
169Bifid scrotum (HP:0000048)1.56060498
170Upper limb amyotrophy (HP:0009129)1.55462960
171Distal upper limb amyotrophy (HP:0007149)1.55462960
172Nephropathy (HP:0000112)1.55370011
173Late onset (HP:0003584)1.54727238
174Aplasia/Hypoplasia of the spleen (HP:0010451)1.53093051
175Abnormality of the dental pulp (HP:0006479)1.51874479
176Abnormal drinking behavior (HP:0030082)1.51117861
177Polydipsia (HP:0001959)1.51117861
178Agitation (HP:0000713)1.50683676
179Polyphagia (HP:0002591)1.50219477
180Craniofacial dystonia (HP:0012179)1.50167402
181Intention tremor (HP:0002080)1.49920338
182Furrowed tongue (HP:0000221)1.48988655
183Epileptiform EEG discharges (HP:0011182)1.47989965
184Tubulointerstitial abnormality (HP:0001969)1.47816567
185Asplenia (HP:0001746)1.47293000
186Abnormal eating behavior (HP:0100738)1.45506563
187Focal motor seizures (HP:0011153)1.44332792
188Anxiety (HP:0000739)1.43999961
189Postaxial hand polydactyly (HP:0001162)1.43458656
190EEG with generalized epileptiform discharges (HP:0011198)1.42888748
191Ketoacidosis (HP:0001993)1.42784635
192Glucose intolerance (HP:0000833)1.42294460
193Vascular calcification (HP:0004934)1.40703589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.34361458
2DDR23.86213899
3STK393.85485448
4OXSR13.75709579
5EPHB23.14338549
6MET2.89524843
7MAPK152.87717808
8NTRK32.72232148
9STK38L2.54308563
10FGFR22.53979341
11STK242.34501573
12WNK42.20150250
13BCR2.19901797
14DAPK22.19265645
15FRK2.16814657
16MST1R2.00986111
17CASK1.98297503
18PRKD31.98041377
19MAPKAPK31.88412538
20PDK21.86606528
21FGR1.85633401
22WNK11.85618860
23MAP2K61.76001415
24MAP3K31.75260817
25LIMK11.72243326
26PAK61.69846859
27MAP3K41.65646692
28PINK11.63713714
29CAMKK11.60707462
30EPHA21.54075819
31MINK11.53851160
32NME11.52534852
33SIK11.50225350
34CSNK1A1L1.49611867
35CSNK1G11.48434364
36FGFR31.48040393
37EPHB11.46549194
38TESK11.44233347
39MAP3K61.37796887
40LRRK21.37723295
41NEK61.30413223
42PAK31.24897578
43PIK3CG1.21524345
44CSNK1G31.19966855
45RIPK11.17672303
46MAP3K121.15124073
47MARK11.13215546
48PDK41.12948097
49PDK31.12948097
50MAP2K71.10703046
51TRPM71.07822648
52GSK3A1.04339278
53ALK1.04169740
54KSR21.03111154
55NTRK21.02281298
56TAOK10.96830822
57INSRR0.96478508
58ROCK20.92174854
59MAPKAPK50.89258910
60LMTK20.86682929
61MAP3K70.86371677
62MST40.86230734
63PRKCG0.83137588
64MAPK130.80664547
65MAP3K20.79615057
66NTRK10.77966686
67ERBB30.77069341
68CAMK10.76987723
69PDPK10.76959672
70MAP2K40.76476959
71CAMK2A0.75320978
72SGK10.74401551
73DYRK1B0.73738185
74TIE10.72087988
75CSNK1G20.71072314
76CAMK2D0.69586666
77SGK20.68927673
78STK110.67621577
79GRK10.67499819
80PRKG20.66250680
81EPHA30.66123362
82CAMKK20.65740591
83BMX0.65496850
84MAP3K90.64909974
85DYRK20.63813062
86DAPK10.63193973
87GRK50.62572778
88UHMK10.62376488
89PRKCQ0.62037155
90TNK20.61697101
91STK100.61507380
92WNK30.60169808
93PKN10.57476590
94SIK20.57106663
95PRKAA20.56964512
96ERBB40.56834791
97FER0.56487301
98CDK60.56414726
99PRKCZ0.56235202
100EPHA40.56157971
101CSNK1D0.55329551
102CDK190.53605005
103MAP3K110.52173032
104ABL20.52159739
105MARK20.51947698
106ERBB20.51565111
107KSR10.49677489
108PRKAA10.49512192
109SGK30.48798031
110PHKG20.48651054
111PHKG10.48651054
112NLK0.47586543
113SGK4940.47390247
114SGK2230.47390247
115MAP2K10.46933019
116PAK40.46807208
117PDK10.46330535
118PAK20.46180401
119PRKACA0.45844875
120PTK20.45393450
121FGFR40.45380550
122MYLK0.44903868
123CSNK1A10.44360958
124PRKG10.43622423
125MAP2K20.43594673
126PRKCA0.43490419
127PLK20.43134854
128ILK0.43061104
129ADRBK20.42251904
130RPS6KA40.41457734
131PRKCH0.40707310
132PRKCI0.38881050
133PRKCD0.38060863
134RPS6KA50.36369399
135PTK2B0.36318532
136LATS20.35594974
137CAMK2G0.35016886
138DYRK1A0.34983726
139TSSK60.33966330
140CAMK2B0.32900175
141CSNK1E0.32480938
142ROCK10.29397536
143PRKCE0.28673771
144LATS10.27762780
145HIPK20.27295342
146IGF1R0.26610132
147CDK50.25864461
148STK380.25330897
149TNIK0.25218064

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.51634322
2Fatty acid elongation_Homo sapiens_hsa000623.34501059
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.17370615
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.76577460
5Sulfur metabolism_Homo sapiens_hsa009202.71049446
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.60139739
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.53608228
8Selenocompound metabolism_Homo sapiens_hsa004502.44490291
9Steroid biosynthesis_Homo sapiens_hsa001002.43858689
10Synaptic vesicle cycle_Homo sapiens_hsa047212.38864736
11Chemical carcinogenesis_Homo sapiens_hsa052042.34998994
12Histidine metabolism_Homo sapiens_hsa003402.29774543
13Glutathione metabolism_Homo sapiens_hsa004802.28660875
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.25421394
15Protein digestion and absorption_Homo sapiens_hsa049742.12141941
16Insulin secretion_Homo sapiens_hsa049112.09793200
17Butanoate metabolism_Homo sapiens_hsa006502.04851976
18Caffeine metabolism_Homo sapiens_hsa002321.99685815
19Nicotine addiction_Homo sapiens_hsa050331.99440520
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93128440
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87895248
22Tryptophan metabolism_Homo sapiens_hsa003801.70882221
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67264353
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62116724
25Protein export_Homo sapiens_hsa030601.60031299
26Amphetamine addiction_Homo sapiens_hsa050311.58677804
27Phenylalanine metabolism_Homo sapiens_hsa003601.57136178
28Malaria_Homo sapiens_hsa051441.52595138
29beta-Alanine metabolism_Homo sapiens_hsa004101.50687801
30Propanoate metabolism_Homo sapiens_hsa006401.48341030
31Circadian entrainment_Homo sapiens_hsa047131.40151621
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38509587
33Fatty acid metabolism_Homo sapiens_hsa012121.35008069
34Arginine and proline metabolism_Homo sapiens_hsa003301.31743580
35Sphingolipid metabolism_Homo sapiens_hsa006001.29425003
36GABAergic synapse_Homo sapiens_hsa047271.28990998
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26883385
38Dopaminergic synapse_Homo sapiens_hsa047281.25348883
39Glutamatergic synapse_Homo sapiens_hsa047241.24893068
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21353327
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18675806
42Focal adhesion_Homo sapiens_hsa045101.18613583
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18401241
44Renin secretion_Homo sapiens_hsa049241.17310918
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15904248
46Hedgehog signaling pathway_Homo sapiens_hsa043401.14066933
47Basal cell carcinoma_Homo sapiens_hsa052171.13424788
48Retinol metabolism_Homo sapiens_hsa008301.12327761
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.12281055
50Gastric acid secretion_Homo sapiens_hsa049711.10922898
51Vitamin B6 metabolism_Homo sapiens_hsa007501.08525430
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07528320
53Phagosome_Homo sapiens_hsa041451.06130178
54Tight junction_Homo sapiens_hsa045301.05445620
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05289278
56Fatty acid degradation_Homo sapiens_hsa000711.04406941
57Taste transduction_Homo sapiens_hsa047421.03137419
58Pancreatic secretion_Homo sapiens_hsa049721.00581216
59Hippo signaling pathway_Homo sapiens_hsa043900.99925131
60Arachidonic acid metabolism_Homo sapiens_hsa005900.99465668
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96807638
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95830059
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94493400
64Huntingtons disease_Homo sapiens_hsa050160.93378982
65Phototransduction_Homo sapiens_hsa047440.93242865
66Non-homologous end-joining_Homo sapiens_hsa034500.92812385
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92315964
68Ether lipid metabolism_Homo sapiens_hsa005650.92246004
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88784114
70Axon guidance_Homo sapiens_hsa043600.88378966
71Tyrosine metabolism_Homo sapiens_hsa003500.87249330
72Mineral absorption_Homo sapiens_hsa049780.85788905
73Morphine addiction_Homo sapiens_hsa050320.85227236
74Long-term potentiation_Homo sapiens_hsa047200.83816557
75TGF-beta signaling pathway_Homo sapiens_hsa043500.82222502
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.81396631
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78969133
78Peroxisome_Homo sapiens_hsa041460.78849280
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78098413
80cAMP signaling pathway_Homo sapiens_hsa040240.77515411
81Cardiac muscle contraction_Homo sapiens_hsa042600.77412754
82PPAR signaling pathway_Homo sapiens_hsa033200.76496635
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75628436
84Rheumatoid arthritis_Homo sapiens_hsa053230.74695116
85Calcium signaling pathway_Homo sapiens_hsa040200.70906569
86Oxytocin signaling pathway_Homo sapiens_hsa049210.69775287
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69711632
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69076433
89Lysine degradation_Homo sapiens_hsa003100.68206249
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67535217
91Folate biosynthesis_Homo sapiens_hsa007900.66188074
92Thyroid hormone synthesis_Homo sapiens_hsa049180.66106723
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64639550
94Ovarian steroidogenesis_Homo sapiens_hsa049130.64039086
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62948051
96Collecting duct acid secretion_Homo sapiens_hsa049660.61891828
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.61835536
98Linoleic acid metabolism_Homo sapiens_hsa005910.60596430
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60550847
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59617670
101Glucagon signaling pathway_Homo sapiens_hsa049220.59091431
102Vibrio cholerae infection_Homo sapiens_hsa051100.58976241
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58956572
104Type II diabetes mellitus_Homo sapiens_hsa049300.57519626
105Starch and sucrose metabolism_Homo sapiens_hsa005000.57393209
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56955836
107Arginine biosynthesis_Homo sapiens_hsa002200.55783615
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55380926
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53170644
110Pyruvate metabolism_Homo sapiens_hsa006200.53153970
111Oxidative phosphorylation_Homo sapiens_hsa001900.52954695
112Fat digestion and absorption_Homo sapiens_hsa049750.52305644
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.52034660
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51995156
115Bile secretion_Homo sapiens_hsa049760.50101616
116Cocaine addiction_Homo sapiens_hsa050300.49881932
117Prion diseases_Homo sapiens_hsa050200.49457826
118Fatty acid biosynthesis_Homo sapiens_hsa000610.49167745
119Complement and coagulation cascades_Homo sapiens_hsa046100.48004318
120Vitamin digestion and absorption_Homo sapiens_hsa049770.47958637
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.47325996
122ABC transporters_Homo sapiens_hsa020100.44876648
123GnRH signaling pathway_Homo sapiens_hsa049120.43898351
124Cholinergic synapse_Homo sapiens_hsa047250.43127153
125Melanogenesis_Homo sapiens_hsa049160.42583821
126Regulation of autophagy_Homo sapiens_hsa041400.41041137
127Long-term depression_Homo sapiens_hsa047300.37253200
128Prostate cancer_Homo sapiens_hsa052150.34904742
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34591796
130Olfactory transduction_Homo sapiens_hsa047400.32939032
131Proteoglycans in cancer_Homo sapiens_hsa052050.32787335
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31110128
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30985656
134Serotonergic synapse_Homo sapiens_hsa047260.30436190
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29799731
136Lysosome_Homo sapiens_hsa041420.29776646
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29756464
138Metabolic pathways_Homo sapiens_hsa011000.29126380
139Salivary secretion_Homo sapiens_hsa049700.25730537
140Bladder cancer_Homo sapiens_hsa052190.25170179
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24224663
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22813664
143Circadian rhythm_Homo sapiens_hsa047100.22261643
144Nitrogen metabolism_Homo sapiens_hsa009100.20050340

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