ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell migration in hindbrain (GO:0021535)	4.22091154
2	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.87680434
3	establishment of nucleus localization (GO:0040023)	3.60068166
4	paraxial mesoderm development (GO:0048339)	3.49064456
5	camera-type eye morphogenesis (GO:0048593)	3.45356531
6	surfactant homeostasis (GO:0043129)	3.43735636
7	lateral sprouting from an epithelium (GO:0060601)	3.30026750
8	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	3.28261992
9	apical protein localization (GO:0045176)	3.23893424
10	cell-cell junction maintenance (GO:0045217)	3.18999495
11	cell junction maintenance (GO:0034331)	3.17614085
12	desmosome organization (GO:0002934)	3.17234681
13	semaphorin-plexin signaling pathway (GO:0071526)	3.13717558
14	chemical homeostasis within a tissue (GO:0048875)	3.08930422
15	regulation of transforming growth factor beta2 production (GO:0032909)	3.06403708
16	layer formation in cerebral cortex (GO:0021819)	3.03470275
17	notochord development (GO:0030903)	3.02290259
18	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.99704047
19	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.94708770
20	hippo signaling (GO:0035329)	2.92228117
21	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.90958164
22	myelination in peripheral nervous system (GO:0022011)	2.80876028
23	peripheral nervous system axon ensheathment (GO:0032292)	2.80876028
24	adherens junction assembly (GO:0034333)	2.79113986
25	auditory behavior (GO:0031223)	2.75209388
26	regulation of NFAT protein import into nucleus (GO:0051532)	2.74987758
27	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.72378449
28	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	2.70632033
29	asymmetric protein localization (GO:0008105)	2.68771450
30	cell communication involved in cardiac conduction (GO:0086065)	2.65190810
31	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.60975452
32	establishment or maintenance of bipolar cell polarity (GO:0061245)	2.57887844
33	establishment or maintenance of apical/basal cell polarity (GO:0035088)	2.57887844
34	regulation of phospholipid biosynthetic process (GO:0071071)	2.57781212
35	cerebellar granule cell differentiation (GO:0021707)	2.56249785
36	ventricular cardiac muscle cell action potential (GO:0086005)	2.55213557
37	cell communication by electrical coupling (GO:0010644)	2.55047206
38	gap junction assembly (GO:0016264)	2.53139712
39	regulation of synapse structural plasticity (GO:0051823)	2.53118857
40	mating behavior (GO:0007617)	2.52550828
41	pyrimidine nucleobase catabolic process (GO:0006208)	2.47380083
42	lens morphogenesis in camera-type eye (GO:0002089)	2.47083040
43	dopamine receptor signaling pathway (GO:0007212)	2.45464608
44	establishment of planar polarity (GO:0001736)	2.44987583
45	establishment of tissue polarity (GO:0007164)	2.44987583
46	epithelial cell-cell adhesion (GO:0090136)	2.44646795
47	neuron recognition (GO:0008038)	2.43879283
48	collecting duct development (GO:0072044)	2.43192036
49	lung-associated mesenchyme development (GO:0060484)	2.42990047
50	gastrulation with mouth forming second (GO:0001702)	2.41467820
51	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.40666688
52	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	2.40600961
53	dendritic spine morphogenesis (GO:0060997)	2.38408918
54	axon extension (GO:0048675)	2.36880222
55	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.32494036
56	adherens junction organization (GO:0034332)	2.31788625
57	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.31446288
58	axonal fasciculation (GO:0007413)	2.31089310
59	negative regulation of catenin import into nucleus (GO:0035414)	2.30772258
60	regulation of mitotic spindle organization (GO:0060236)	2.30222212
61	vocalization behavior (GO:0071625)	2.28409331
62	nucleus localization (GO:0051647)	2.27677852
63	body morphogenesis (GO:0010171)	2.27624188
64	response to inactivity (GO:0014854)	2.27125989
65	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.26600491
66	convergent extension (GO:0060026)	2.26416261
67	neuron projection extension (GO:1990138)	2.26265903
68	neuronal ion channel clustering (GO:0045161)	2.26113424
69	cell-substrate adherens junction assembly (GO:0007045)	2.25616213
70	focal adhesion assembly (GO:0048041)	2.25616213
71	developmental cell growth (GO:0048588)	2.23515280
72	* ephrin receptor signaling pathway (GO:0048013)	2.22581284
73	myoblast fusion (GO:0007520)	2.20767433
74	polyol transport (GO:0015791)	2.19197420
75	sodium ion export (GO:0071436)	2.18820281
76	polarized epithelial cell differentiation (GO:0030859)	2.18702845
77	neural tube development (GO:0021915)	2.17161348
78	cardiac myofibril assembly (GO:0055003)	2.16857847
79	myotube differentiation (GO:0014902)	2.15651820
80	protein localization to microtubule (GO:0035372)	2.13218530
81	negative regulation of chondrocyte differentiation (GO:0032331)	2.12554423
82	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.11537101
83	non-canonical Wnt signaling pathway (GO:0035567)	2.10079976
84	negative regulation of cartilage development (GO:0061037)	2.09071090
85	cellular response to monoamine stimulus (GO:0071868)	2.08804286
86	cellular response to catecholamine stimulus (GO:0071870)	2.08804286
87	branching involved in salivary gland morphogenesis (GO:0060445)	2.07198333
88	cellular component maintenance (GO:0043954)	2.06470670
89	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.05513354
90	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.05163031
91	peptidyl-lysine dimethylation (GO:0018027)	2.05039184
92	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.04996130
93	axon extension involved in axon guidance (GO:0048846)	2.04996130
94	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.04797334
95	syncytium formation by plasma membrane fusion (GO:0000768)	2.04075274
96	establishment of spindle orientation (GO:0051294)	2.02451104
97	lung epithelium development (GO:0060428)	2.01582127
98	neuromuscular junction development (GO:0007528)	2.00360394
99	eye morphogenesis (GO:0048592)	1.99634195
100	histone H3-K9 demethylation (GO:0033169)	1.99398285

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.72802437
2	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.59243951
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.40583622
4	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	2.25147269
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.18118310
6	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.16783449
7	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.13134828
8	KDM2B_26808549_Chip-Seq_K562_Human	2.11559215
9	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	2.10956265
10	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.99997604
11	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.98522662
12	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.98522662
13	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.97162876
14	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.95009169
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.89937600
16	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.83625523
17	ZNF263_19887448_ChIP-Seq_K562_Human	1.78072678
18	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.73291622
19	DROSHA_22980978_ChIP-Seq_HELA_Human	1.72689811
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.70321514
21	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.69081939
22	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.65206185
23	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.65114164
24	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.64053082
25	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.61781561
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.60005862
27	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.57178908
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.53119118
29	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.52935114
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.52393113
31	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.51190399
32	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.50303338
33	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.49902291
34	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.49709679
35	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.48307089
36	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.45655264
37	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.44511753
38	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.43292848
39	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.41185721
40	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.40910863
41	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.40082796
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.39377253
43	CLOCK_20551151_ChIP-Seq_293T_Human	1.38724689
44	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.38481719
45	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.37399328
46	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.37326470
47	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.37242396
48	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.36963458
49	CTCF_27219007_Chip-Seq_Bcells_Human	1.36442046
50	AHR_22903824_ChIP-Seq_MCF-7_Human	1.34879599
51	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.34800037
52	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.33081889
53	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.32448011
54	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.32351686
55	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.31511796
56	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.29397348
57	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.29219854
58	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.26542825
59	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.24995479
60	LXR_22292898_ChIP-Seq_THP-1_Human	1.24203040
61	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.23444933
62	RACK7_27058665_Chip-Seq_MCF-7_Human	1.22734137
63	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.18716736
64	* CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.18694321
65	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.17235606
66	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.16754508
67	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.16626937
68	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.16017018
69	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.16009565
70	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.15838245
71	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.15288445
72	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.15284936
73	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.11495341
74	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.11119976
75	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.11119976
76	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	1.10446952
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09126304
78	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.08435434
79	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.05715933
80	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.05229251
81	KDM2B_26808549_Chip-Seq_DND41_Human	1.05188030
82	AR_19668381_ChIP-Seq_PC3_Human	1.04113833
83	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.03823246
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01580689
85	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.00385849
86	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.00001852
87	SMC4_20622854_ChIP-Seq_HELA_Human	0.99978319
88	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.99465516
89	* FOXA2_19822575_ChIP-Seq_HepG2_Human	0.99034613
90	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.97936047
91	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.96492633
92	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96249599
93	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.95809784
94	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.92795139
95	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.92489838
96	CREB1_26743006_Chip-Seq_LNCaP_Human	0.92103655
97	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.92043257
98	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.91949632
99	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.90457632
100	TCF7_22412390_ChIP-Seq_EML_Mouse	0.88911707

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.38357766
2	MP0005409_darkened_coat_color	3.25337016
3	MP0000566_synostosis	3.14844766
4	MP0000537_abnormal_urethra_morphology	2.68129372
5	MP0003705_abnormal_hypodermis_morpholog	2.61088324
6	MP0001188_hyperpigmentation	2.51633725
7	MP0004270_analgesia	2.50548791
8	MP0003878_abnormal_ear_physiology	2.42420740
9	MP0005377_hearing/vestibular/ear_phenot	2.42420740
10	MP0003122_maternal_imprinting	2.07850238
11	MP0004264_abnormal_extraembryonic_tissu	1.97796281
12	MP0010030_abnormal_orbit_morphology	1.89226914
13	MP0010234_abnormal_vibrissa_follicle	1.85424066
14	MP0004782_abnormal_surfactant_physiolog	1.80457704
15	MP0000778_abnormal_nervous_system	1.78013511
16	MP0003890_abnormal_embryonic-extraembry	1.75050385
17	MP0004859_abnormal_synaptic_plasticity	1.73179705
18	MP0005248_abnormal_Harderian_gland	1.68715087
19	MP0003123_paternal_imprinting	1.68029237
20	MP0004858_abnormal_nervous_system	1.63227645
21	MP0000751_myopathy	1.56402128
22	MP0000579_abnormal_nail_morphology	1.54175590
23	MP0005076_abnormal_cell_differentiation	1.48564911
24	MP0002249_abnormal_larynx_morphology	1.45732363
25	MP0004272_abnormal_basement_membrane	1.44851500
26	MP0005394_taste/olfaction_phenotype	1.43352541
27	MP0005499_abnormal_olfactory_system	1.43352541
28	MP0000534_abnormal_ureter_morphology	1.39706811
29	MP0009053_abnormal_anal_canal	1.36080062
30	MP0002909_abnormal_adrenal_gland	1.31283722
31	MP0000462_abnormal_digestive_system	1.30287013
32	MP0004233_abnormal_muscle_weight	1.29404051
33	MP0005257_abnormal_intraocular_pressure	1.26909102
34	MP0003119_abnormal_digestive_system	1.23874946
35	MP0001177_atelectasis	1.22864732
36	MP0006138_congestive_heart_failure	1.21129549
37	MP0003942_abnormal_urinary_system	1.18183866
38	MP0000955_abnormal_spinal_cord	1.17779771
39	MP0001299_abnormal_eye_distance/	1.17565318
40	MP0003879_abnormal_hair_cell	1.16980876
41	MP0003861_abnormal_nervous_system	1.15611730
42	MP0002653_abnormal_ependyma_morphology	1.12531166
43	MP0002697_abnormal_eye_size	1.12092179
44	MP0001346_abnormal_lacrimal_gland	1.11757407
45	MP0003566_abnormal_cell_adhesion	1.11387580
46	MP0002734_abnormal_mechanical_nocicepti	1.10837231
47	MP0002108_abnormal_muscle_morphology	1.09258413
48	MP0003385_abnormal_body_wall	1.08946758
49	MP0001293_anophthalmia	1.08778887
50	MP0002160_abnormal_reproductive_system	1.08059036
51	MP0005670_abnormal_white_adipose	1.07671484
52	MP0002098_abnormal_vibrissa_morphology	1.04819575
53	MP0003329_amyloid_beta_deposits	1.04524957
54	MP0001486_abnormal_startle_reflex	1.02738100
55	MP0010630_abnormal_cardiac_muscle	1.00352701
56	MP0002184_abnormal_innervation	1.00328222
57	MP0004087_abnormal_muscle_fiber	0.99995444
58	MP0003121_genomic_imprinting	0.98986287
59	MP0003635_abnormal_synaptic_transmissio	0.97559116
60	MP0002796_impaired_skin_barrier	0.95760764
61	MP0002092_abnormal_eye_morphology	0.93444661
62	MP0002882_abnormal_neuron_morphology	0.91949181
63	MP0002152_abnormal_brain_morphology	0.91105754
64	MP0000762_abnormal_tongue_morphology	0.89352516
65	MP0008789_abnormal_olfactory_epithelium	0.88458512
66	MP0009703_decreased_birth_body	0.88375880
67	MP0002233_abnormal_nose_morphology	0.87292046
68	MP0002638_abnormal_pupillary_reflex	0.85914135
69	MP0004130_abnormal_muscle_cell	0.85670429
70	MP0002063_abnormal_learning/memory/cond	0.85227904
71	MP0003935_abnormal_craniofacial_develop	0.84709467
72	MP0002081_perinatal_lethality	0.84699682
73	MP0002089_abnormal_postnatal_growth/wei	0.84530738
74	MP0003115_abnormal_respiratory_system	0.83484680
75	MP0009672_abnormal_birth_weight	0.83267084
76	MP0001849_ear_inflammation	0.81027877
77	MP0010678_abnormal_skin_adnexa	0.80486593
78	MP0003938_abnormal_ear_development	0.80414035
79	MP0006276_abnormal_autonomic_nervous	0.79708525
80	MP0004811_abnormal_neuron_physiology	0.79650503
81	MP0002116_abnormal_craniofacial_bone	0.78689303
82	MP0000516_abnormal_urinary_system	0.78615027
83	MP0005367_renal/urinary_system_phenotyp	0.78615027
84	MP0003948_abnormal_gas_homeostasis	0.77623520
85	MP0000432_abnormal_head_morphology	0.74862669
86	MP0003755_abnormal_palate_morphology	0.74568066
87	MP0005666_abnormal_adipose_tissue	0.74331110
88	MP0005275_abnormal_skin_tensile	0.74212625
89	MP0003453_abnormal_keratinocyte_physiol	0.74116678
90	MP0000383_abnormal_hair_follicle	0.73857319
91	MP0003567_abnormal_fetal_cardiomyocyte	0.73274984
92	MP0000377_abnormal_hair_follicle	0.72896832
93	MP0002557_abnormal_social/conspecific_i	0.71612861
94	MP0001727_abnormal_embryo_implantation	0.71507620
95	MP0003634_abnormal_glial_cell	0.70694231
96	MP0002084_abnormal_developmental_patter	0.70168795
97	MP0003937_abnormal_limbs/digits/tail_de	0.69556719
98	MP0003632_abnormal_nervous_system	0.69366595
99	MP0005423_abnormal_somatic_nervous	0.69162302
100	MP0004036_abnormal_muscle_relaxation	0.68913927

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Obstructive sleep apnea (HP:0002870)	2.98785242
2	Right ventricular cardiomyopathy (HP:0011663)	2.82598254
3	High anterior hairline (HP:0009890)	2.75166366
4	Cerebral aneurysm (HP:0004944)	2.70476087
5	Popliteal pterygium (HP:0009756)	2.34344038
6	Heterotopia (HP:0002282)	2.28534978
7	Turricephaly (HP:0000262)	2.26971485
8	Aplasia involving bones of the extremities (HP:0009825)	2.24859907
9	Aplasia involving bones of the upper limbs (HP:0009823)	2.24859907
10	Aplasia of the phalanges of the hand (HP:0009802)	2.24859907
11	Bronchomalacia (HP:0002780)	2.22108780
12	Action tremor (HP:0002345)	2.22062071
13	Ulnar bowing (HP:0003031)	2.21258865
14	Fetal akinesia sequence (HP:0001989)	2.20719477
15	Germ cell neoplasia (HP:0100728)	2.19660890
16	Shallow orbits (HP:0000586)	2.16460414
17	Pterygium (HP:0001059)	2.16016006
18	Asymmetry of the thorax (HP:0001555)	2.12369022
19	Abnormality of the aortic arch (HP:0012303)	2.12016485
20	Thickened helices (HP:0000391)	2.11635737
21	Absent eyebrow (HP:0002223)	2.08295541
22	Choanal stenosis (HP:0000452)	2.05188821
23	Bilateral sensorineural hearing impairment (HP:0008619)	2.03213935
24	Thin ribs (HP:0000883)	2.00779201
25	Abnormality of the salivary glands (HP:0010286)	1.97222034
26	Dysmetric saccades (HP:0000641)	1.96104210
27	Precocious puberty (HP:0000826)	1.95141601
28	Macroorchidism (HP:0000053)	1.94951526
29	Vertebral arch anomaly (HP:0008438)	1.90896306
30	Cutaneous finger syndactyly (HP:0010554)	1.89549349
31	Difficulty running (HP:0009046)	1.86941500
32	Hepatoblastoma (HP:0002884)	1.82876755
33	Aplasia of the musculature (HP:0100854)	1.81172300
34	Bell-shaped thorax (HP:0001591)	1.81061832
35	Cutaneous syndactyly (HP:0012725)	1.81039353
36	Sudden death (HP:0001699)	1.80906284
37	Myokymia (HP:0002411)	1.80184606
38	Partial agenesis of the corpus callosum (HP:0001338)	1.79728776
39	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.79372047
40	Ulnar deviation of the wrist (HP:0003049)	1.78856467
41	Morphological abnormality of the middle ear (HP:0008609)	1.78345919
42	Hyporeflexia of lower limbs (HP:0002600)	1.78102141
43	Neurofibrillary tangles (HP:0002185)	1.77108331
44	Abnormality of the lower motor neuron (HP:0002366)	1.76945694
45	Coronal craniosynostosis (HP:0004440)	1.76815174
46	Hyperacusis (HP:0010780)	1.76078836
47	Round ear (HP:0100830)	1.75351189
48	Lymphangioma (HP:0100764)	1.75082831
49	Intellectual disability, moderate (HP:0002342)	1.74795726
50	Sleep apnea (HP:0010535)	1.73304645
51	Midline defect of the nose (HP:0004122)	1.72946547
52	Abnormality of the fingertips (HP:0001211)	1.72707489
53	Bicornuate uterus (HP:0000813)	1.72490209
54	Hypoplasia of the iris (HP:0007676)	1.72058993
55	Alacrima (HP:0000522)	1.71775188
56	Abnormality of the dental root (HP:0006486)	1.71525996
57	Taurodontia (HP:0000679)	1.71525996
58	Abnormality of permanent molar morphology (HP:0011071)	1.71525996
59	Advanced eruption of teeth (HP:0006288)	1.69726311
60	Osteomalacia (HP:0002749)	1.69442483
61	Shawl scrotum (HP:0000049)	1.69345636
62	Abnormality of the ischium (HP:0003174)	1.69241690
63	Mitral valve prolapse (HP:0001634)	1.69221915
64	Increased connective tissue (HP:0009025)	1.69109984
65	Visceral angiomatosis (HP:0100761)	1.68296987
66	Truncal obesity (HP:0001956)	1.66499840
67	Distal lower limb muscle weakness (HP:0009053)	1.66462879
68	Akinesia (HP:0002304)	1.65691307
69	Absent eyelashes (HP:0000561)	1.65577037
70	Muscle fiber splitting (HP:0003555)	1.65537650
71	Overgrowth (HP:0001548)	1.64561596
72	Omphalocele (HP:0001539)	1.63341125
73	Myelomeningocele (HP:0002475)	1.63111397
74	Metaphyseal cupping (HP:0003021)	1.60894980
75	Exotropia (HP:0000577)	1.60266289
76	Hammertoe (HP:0001765)	1.58154356
77	Hemangiomatosis (HP:0007461)	1.57931154
78	Arnold-Chiari malformation (HP:0002308)	1.57561241
79	Abnormality of molar (HP:0011077)	1.56925909
80	Abnormality of molar morphology (HP:0011070)	1.56925909
81	Depression (HP:0000716)	1.56749557
82	Cerebral inclusion bodies (HP:0100314)	1.56516430
83	Laryngomalacia (HP:0001601)	1.56400949
84	Mask-like facies (HP:0000298)	1.56283339
85	Bundle branch block (HP:0011710)	1.55547603
86	Disproportionate tall stature (HP:0001519)	1.53232338
87	Ventricular tachycardia (HP:0004756)	1.51002126
88	Abnormality of the lacrimal duct (HP:0011481)	1.46225658
89	Flat acetabular roof (HP:0003180)	1.46128632
90	Abnormality of the dental pulp (HP:0006479)	1.45877594
91	Foot dorsiflexor weakness (HP:0009027)	1.44400414
92	Neoplasm of the heart (HP:0100544)	1.44368479
93	Broad metatarsal (HP:0001783)	1.43815707
94	Severe Myopia (HP:0011003)	1.43490536
95	Curly hair (HP:0002212)	1.43253680
96	Mildly elevated creatine phosphokinase (HP:0008180)	1.43128297
97	Menstrual irregularities (HP:0000858)	1.43054906
98	Neonatal hypoglycemia (HP:0001998)	1.42593739
99	Syncope (HP:0001279)	1.42334461
100	Skull defect (HP:0001362)	1.41303139

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.87372110
2	PNCK	3.01086379
3	LATS2	2.84884725
4	MARK1	2.53864085
5	TRIB3	2.38409400
6	ICK	2.32980406
7	CAMK1G	2.26716740
8	RIPK1	2.23156522
9	LATS1	2.21057444
10	AKT3	2.20837767
11	EPHB2	2.18944904
12	CDK12	1.93389521
13	CAMK1D	1.82359387
14	EPHA2	1.81948640
15	CASK	1.80231609
16	EEF2K	1.76111667
17	CDK9	1.71705231
18	FGFR2	1.68106911
19	MARK2	1.48846073
20	NTRK1	1.45889697
21	SGK223	1.41027512
22	SGK494	1.41027512
23	SGK2	1.40143944
24	SGK3	1.30726916
25	MAP3K9	1.30057642
26	MTOR	1.27976307
27	MET	1.24819888
28	SIK1	1.20088803
29	NLK	1.19017198
30	DDR2	1.16640343
31	RPS6KA2	1.16249470
32	PTK2	1.15808575
33	MAP3K6	1.15003800
34	PKN2	1.14418361
35	EPHA3	1.12234535
36	MAPK15	1.12026083
37	PDGFRA	1.08363337
38	MUSK	1.07979965
39	NTRK2	1.05087705
40	SMG1	1.03329055
41	EPHB1	1.00754533
42	DYRK2	1.00082334
43	STK38L	0.99223441
44	LMTK2	0.98299206
45	TYRO3	0.95908429
46	PRKD3	0.94726662
47	TTN	0.92954318
48	MAP3K10	0.92350263
49	STK39	0.88997697
50	STK38	0.87283843
51	BRAF	0.86676778
52	MAP3K7	0.86601187
53	RET	0.80155303
54	MAP2K4	0.79075789
55	FGFR1	0.77729356
56	STK11	0.76812225
57	CDC42BPA	0.76589797
58	NME1	0.75601130
59	TTK	0.74567587
60	WNK1	0.73535143
61	EPHA4	0.73209194
62	CDK5	0.71702132
63	DYRK1B	0.69312072
64	FGFR4	0.68931939
65	MINK1	0.66867056
66	BRD4	0.64238148
67	MST1R	0.63866292
68	PRKCZ	0.63281948
69	PRKAA1	0.62834038
70	PTK6	0.62451132
71	CAMK4	0.61164557
72	NTRK3	0.59837393
73	WNK4	0.59741215
74	PHKG2	0.59466494
75	PHKG1	0.59466494
76	DMPK	0.58378151
77	FER	0.58145925
78	UHMK1	0.55062221
79	MAP3K4	0.54717230
80	TAOK1	0.53756406
81	PRKD2	0.53212383
82	MAPK10	0.52626533
83	PDGFRB	0.52169375
84	ERBB2	0.51309873
85	MAP2K7	0.51068731
86	PAK3	0.48615119
87	RPS6KC1	0.47051237
88	RPS6KL1	0.47051237
89	CSNK1E	0.46771467
90	RPS6KB1	0.46630863
91	PDPK1	0.45931713
92	ROCK2	0.45224816
93	CAMK1	0.44657772
94	NEK6	0.44036407
95	YES1	0.43101027
96	DYRK1A	0.42293438
97	PAK4	0.40830751
98	GSK3B	0.39188739
99	SGK1	0.38457540
100	MAP2K2	0.37204863

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Adherens junction_Homo sapiens_hsa04520	1.93358551
2	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.86977429
3	Axon guidance_Homo sapiens_hsa04360	1.73838721
4	Basal cell carcinoma_Homo sapiens_hsa05217	1.69846702
5	Notch signaling pathway_Homo sapiens_hsa04330	1.68243387
6	Tight junction_Homo sapiens_hsa04530	1.66048336
7	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.62985975
8	Thyroid cancer_Homo sapiens_hsa05216	1.62943218
9	Endometrial cancer_Homo sapiens_hsa05213	1.61007960
10	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.51368535
11	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.51087669
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.50493615
13	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.49662034
14	Hippo signaling pathway_Homo sapiens_hsa04390	1.48189649
15	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.47345629
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.46972836
17	Melanogenesis_Homo sapiens_hsa04916	1.41558951
18	ECM-receptor interaction_Homo sapiens_hsa04512	1.38690622
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.31575313
20	Gap junction_Homo sapiens_hsa04540	1.29633294
21	Cocaine addiction_Homo sapiens_hsa05030	1.21584699
22	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.20754110
23	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.19885089
24	Nicotine addiction_Homo sapiens_hsa05033	1.18366617
25	ErbB signaling pathway_Homo sapiens_hsa04012	1.17504451
26	Focal adhesion_Homo sapiens_hsa04510	1.14501399
27	Wnt signaling pathway_Homo sapiens_hsa04310	1.13774022
28	AMPK signaling pathway_Homo sapiens_hsa04152	1.13281694
29	Lysine degradation_Homo sapiens_hsa00310	1.12392954
30	Renal cell carcinoma_Homo sapiens_hsa05211	1.10599565
31	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.09185662
32	GnRH signaling pathway_Homo sapiens_hsa04912	1.06719606
33	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.06362439
34	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.05789260
35	Estrogen signaling pathway_Homo sapiens_hsa04915	1.05522837
36	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.03665807
37	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.03636553
38	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.03213934
39	Long-term potentiation_Homo sapiens_hsa04720	1.01696528
40	Colorectal cancer_Homo sapiens_hsa05210	0.98088526
41	Insulin signaling pathway_Homo sapiens_hsa04910	0.97447765
42	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.97312196
43	VEGF signaling pathway_Homo sapiens_hsa04370	0.92866036
44	Choline metabolism in cancer_Homo sapiens_hsa05231	0.92621667
45	Dopaminergic synapse_Homo sapiens_hsa04728	0.92340343
46	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.92121087
47	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.91447003
48	Prostate cancer_Homo sapiens_hsa05215	0.91243295
49	Rap1 signaling pathway_Homo sapiens_hsa04015	0.90971585
50	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.90008250
51	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.89840215
52	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.89804085
53	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.88760493
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.86370455
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85943286
56	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.85806934
57	Histidine metabolism_Homo sapiens_hsa00340	0.84160261
58	Cholinergic synapse_Homo sapiens_hsa04725	0.83992246
59	mTOR signaling pathway_Homo sapiens_hsa04150	0.83440163
60	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.80713145
61	Amoebiasis_Homo sapiens_hsa05146	0.80294388
62	Gastric acid secretion_Homo sapiens_hsa04971	0.79905430
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.79866581
64	Long-term depression_Homo sapiens_hsa04730	0.79639632
65	Proteoglycans in cancer_Homo sapiens_hsa05205	0.79004429
66	Insulin secretion_Homo sapiens_hsa04911	0.78575212
67	Bile secretion_Homo sapiens_hsa04976	0.78467982
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78206564
69	Glioma_Homo sapiens_hsa05214	0.77937772
70	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.77250368
71	Circadian entrainment_Homo sapiens_hsa04713	0.76791143
72	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.75849644
73	Glucagon signaling pathway_Homo sapiens_hsa04922	0.75577820
74	Type II diabetes mellitus_Homo sapiens_hsa04930	0.74784115
75	MicroRNAs in cancer_Homo sapiens_hsa05206	0.70000787
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.69814204
77	Ras signaling pathway_Homo sapiens_hsa04014	0.69648212
78	GABAergic synapse_Homo sapiens_hsa04727	0.69607479
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.69069786
80	Pathways in cancer_Homo sapiens_hsa05200	0.68114030
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68013817
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.67633132
83	Acute myeloid leukemia_Homo sapiens_hsa05221	0.67184770
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.65209401
85	Amphetamine addiction_Homo sapiens_hsa05031	0.64619401
86	Non-small cell lung cancer_Homo sapiens_hsa05223	0.64597433
87	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.64040984
88	Galactose metabolism_Homo sapiens_hsa00052	0.61200106
89	Protein digestion and absorption_Homo sapiens_hsa04974	0.60483549
90	Insulin resistance_Homo sapiens_hsa04931	0.60476375
91	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.60212438
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.59907400
93	Morphine addiction_Homo sapiens_hsa05032	0.59785239
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.58931149
95	Renin secretion_Homo sapiens_hsa04924	0.58304151
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.58049046
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.57488608
98	Endocytosis_Homo sapiens_hsa04144	0.57263264
99	Circadian rhythm_Homo sapiens_hsa04710	0.57123604
100	Prion diseases_Homo sapiens_hsa05020	0.56676867

ANKS1A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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