ANKS1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.22091154
2cytoskeletal anchoring at plasma membrane (GO:0007016)3.87680434
3establishment of nucleus localization (GO:0040023)3.60068166
4paraxial mesoderm development (GO:0048339)3.49064456
5camera-type eye morphogenesis (GO:0048593)3.45356531
6surfactant homeostasis (GO:0043129)3.43735636
7lateral sprouting from an epithelium (GO:0060601)3.30026750
8neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.28261992
9apical protein localization (GO:0045176)3.23893424
10cell-cell junction maintenance (GO:0045217)3.18999495
11cell junction maintenance (GO:0034331)3.17614085
12desmosome organization (GO:0002934)3.17234681
13semaphorin-plexin signaling pathway (GO:0071526)3.13717558
14chemical homeostasis within a tissue (GO:0048875)3.08930422
15regulation of transforming growth factor beta2 production (GO:0032909)3.06403708
16layer formation in cerebral cortex (GO:0021819)3.03470275
17notochord development (GO:0030903)3.02290259
18planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99704047
19dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.94708770
20hippo signaling (GO:0035329)2.92228117
21bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90958164
22peripheral nervous system axon ensheathment (GO:0032292)2.80876028
23myelination in peripheral nervous system (GO:0022011)2.80876028
24adherens junction assembly (GO:0034333)2.79113986
25auditory behavior (GO:0031223)2.75209388
26regulation of NFAT protein import into nucleus (GO:0051532)2.74987758
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72378449
28establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.70632033
29asymmetric protein localization (GO:0008105)2.68771450
30cell communication involved in cardiac conduction (GO:0086065)2.65190810
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60975452
32establishment or maintenance of apical/basal cell polarity (GO:0035088)2.57887844
33establishment or maintenance of bipolar cell polarity (GO:0061245)2.57887844
34regulation of phospholipid biosynthetic process (GO:0071071)2.57781212
35cerebellar granule cell differentiation (GO:0021707)2.56249785
36ventricular cardiac muscle cell action potential (GO:0086005)2.55213557
37cell communication by electrical coupling (GO:0010644)2.55047206
38gap junction assembly (GO:0016264)2.53139712
39regulation of synapse structural plasticity (GO:0051823)2.53118857
40mating behavior (GO:0007617)2.52550828
41pyrimidine nucleobase catabolic process (GO:0006208)2.47380083
42lens morphogenesis in camera-type eye (GO:0002089)2.47083040
43dopamine receptor signaling pathway (GO:0007212)2.45464608
44establishment of planar polarity (GO:0001736)2.44987583
45establishment of tissue polarity (GO:0007164)2.44987583
46epithelial cell-cell adhesion (GO:0090136)2.44646795
47neuron recognition (GO:0008038)2.43879283
48collecting duct development (GO:0072044)2.43192036
49lung-associated mesenchyme development (GO:0060484)2.42990047
50gastrulation with mouth forming second (GO:0001702)2.41467820
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40666688
52regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.40600961
53dendritic spine morphogenesis (GO:0060997)2.38408918
54axon extension (GO:0048675)2.36880222
55embryonic retina morphogenesis in camera-type eye (GO:0060059)2.32494036
56adherens junction organization (GO:0034332)2.31788625
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.31446288
58axonal fasciculation (GO:0007413)2.31089310
59negative regulation of catenin import into nucleus (GO:0035414)2.30772258
60regulation of mitotic spindle organization (GO:0060236)2.30222212
61vocalization behavior (GO:0071625)2.28409331
62nucleus localization (GO:0051647)2.27677852
63body morphogenesis (GO:0010171)2.27624188
64response to inactivity (GO:0014854)2.27125989
65negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.26600491
66convergent extension (GO:0060026)2.26416261
67neuron projection extension (GO:1990138)2.26265903
68neuronal ion channel clustering (GO:0045161)2.26113424
69focal adhesion assembly (GO:0048041)2.25616213
70cell-substrate adherens junction assembly (GO:0007045)2.25616213
71developmental cell growth (GO:0048588)2.23515280
72* ephrin receptor signaling pathway (GO:0048013)2.22581284
73myoblast fusion (GO:0007520)2.20767433
74polyol transport (GO:0015791)2.19197420
75sodium ion export (GO:0071436)2.18820281
76polarized epithelial cell differentiation (GO:0030859)2.18702845
77neural tube development (GO:0021915)2.17161348
78cardiac myofibril assembly (GO:0055003)2.16857847
79myotube differentiation (GO:0014902)2.15651820
80protein localization to microtubule (GO:0035372)2.13218530
81negative regulation of chondrocyte differentiation (GO:0032331)2.12554423
82Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.11537101
83non-canonical Wnt signaling pathway (GO:0035567)2.10079976
84negative regulation of cartilage development (GO:0061037)2.09071090
85cellular response to catecholamine stimulus (GO:0071870)2.08804286
86cellular response to monoamine stimulus (GO:0071868)2.08804286
87branching involved in salivary gland morphogenesis (GO:0060445)2.07198333
88cellular component maintenance (GO:0043954)2.06470670
89negative regulation of potassium ion transmembrane transport (GO:1901380)2.05513354
90epithelial cell differentiation involved in prostate gland development (GO:0060742)2.05163031
91peptidyl-lysine dimethylation (GO:0018027)2.05039184
92neuron projection extension involved in neuron projection guidance (GO:1902284)2.04996130
93axon extension involved in axon guidance (GO:0048846)2.04996130
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.04797334
95syncytium formation by plasma membrane fusion (GO:0000768)2.04075274
96establishment of spindle orientation (GO:0051294)2.02451104
97lung epithelium development (GO:0060428)2.01582127
98neuromuscular junction development (GO:0007528)2.00360394
99eye morphogenesis (GO:0048592)1.99634195
100histone H3-K9 demethylation (GO:0033169)1.99398285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.72802437
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.59243951
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40583622
4SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.25147269
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18118310
6TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.16783449
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.13134828
8KDM2B_26808549_Chip-Seq_K562_Human2.11559215
9EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.10956265
10ERG_21242973_ChIP-ChIP_JURKAT_Human1.99997604
11RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98522662
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98522662
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97162876
14ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95009169
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.89937600
16RNF2_27304074_Chip-Seq_ESCs_Mouse1.83625523
17ZNF263_19887448_ChIP-Seq_K562_Human1.78072678
18ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73291622
19DROSHA_22980978_ChIP-Seq_HELA_Human1.72689811
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70321514
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69081939
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65206185
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65114164
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.64053082
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61781561
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60005862
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57178908
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53119118
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52935114
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.52393113
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51190399
32OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.50303338
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.49902291
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49709679
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.48307089
36RING1B_27294783_Chip-Seq_NPCs_Mouse1.45655264
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44511753
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43292848
39ISL1_27105846_Chip-Seq_CPCs_Mouse1.41185721
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40910863
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40082796
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39377253
43CLOCK_20551151_ChIP-Seq_293T_Human1.38724689
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38481719
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37399328
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37326470
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37242396
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36963458
49CTCF_27219007_Chip-Seq_Bcells_Human1.36442046
50AHR_22903824_ChIP-Seq_MCF-7_Human1.34879599
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34800037
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.33081889
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32448011
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32351686
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31511796
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.29397348
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29219854
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.26542825
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.24995479
60LXR_22292898_ChIP-Seq_THP-1_Human1.24203040
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23444933
62RACK7_27058665_Chip-Seq_MCF-7_Human1.22734137
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18716736
64* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18694321
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17235606
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16754508
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.16626937
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.16017018
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.16009565
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15838245
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15288445
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.15284936
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.11495341
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.11119976
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.11119976
76PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10446952
77REST_21632747_ChIP-Seq_MESCs_Mouse1.09126304
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08435434
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05715933
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05229251
81KDM2B_26808549_Chip-Seq_DND41_Human1.05188030
82AR_19668381_ChIP-Seq_PC3_Human1.04113833
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03823246
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.01580689
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00385849
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00001852
87SMC4_20622854_ChIP-Seq_HELA_Human0.99978319
88DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99465516
89* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99034613
90TET1_21490601_ChIP-Seq_MESCs_Mouse0.97936047
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96492633
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96249599
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95809784
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92795139
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92489838
96CREB1_26743006_Chip-Seq_LNCaP_Human0.92103655
97TP53_23651856_ChIP-Seq_MEFs_Mouse0.92043257
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.91949632
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90457632
100TCF7_22412390_ChIP-Seq_EML_Mouse0.88911707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.38357766
2MP0005409_darkened_coat_color3.25337016
3MP0000566_synostosis3.14844766
4MP0000537_abnormal_urethra_morphology2.68129372
5MP0003705_abnormal_hypodermis_morpholog2.61088324
6MP0001188_hyperpigmentation2.51633725
7MP0004270_analgesia2.50548791
8MP0003878_abnormal_ear_physiology2.42420740
9MP0005377_hearing/vestibular/ear_phenot2.42420740
10MP0003122_maternal_imprinting2.07850238
11MP0004264_abnormal_extraembryonic_tissu1.97796281
12MP0010030_abnormal_orbit_morphology1.89226914
13MP0010234_abnormal_vibrissa_follicle1.85424066
14MP0004782_abnormal_surfactant_physiolog1.80457704
15MP0000778_abnormal_nervous_system1.78013511
16MP0003890_abnormal_embryonic-extraembry1.75050385
17MP0004859_abnormal_synaptic_plasticity1.73179705
18MP0005248_abnormal_Harderian_gland1.68715087
19MP0003123_paternal_imprinting1.68029237
20MP0004858_abnormal_nervous_system1.63227645
21MP0000751_myopathy1.56402128
22MP0000579_abnormal_nail_morphology1.54175590
23MP0005076_abnormal_cell_differentiation1.48564911
24MP0002249_abnormal_larynx_morphology1.45732363
25MP0004272_abnormal_basement_membrane1.44851500
26MP0005394_taste/olfaction_phenotype1.43352541
27MP0005499_abnormal_olfactory_system1.43352541
28MP0000534_abnormal_ureter_morphology1.39706811
29MP0009053_abnormal_anal_canal1.36080062
30MP0002909_abnormal_adrenal_gland1.31283722
31MP0000462_abnormal_digestive_system1.30287013
32MP0004233_abnormal_muscle_weight1.29404051
33MP0005257_abnormal_intraocular_pressure1.26909102
34MP0003119_abnormal_digestive_system1.23874946
35MP0001177_atelectasis1.22864732
36MP0006138_congestive_heart_failure1.21129549
37MP0003942_abnormal_urinary_system1.18183866
38MP0000955_abnormal_spinal_cord1.17779771
39MP0001299_abnormal_eye_distance/1.17565318
40MP0003879_abnormal_hair_cell1.16980876
41MP0003861_abnormal_nervous_system1.15611730
42MP0002653_abnormal_ependyma_morphology1.12531166
43MP0002697_abnormal_eye_size1.12092179
44MP0001346_abnormal_lacrimal_gland1.11757407
45MP0003566_abnormal_cell_adhesion1.11387580
46MP0002734_abnormal_mechanical_nocicepti1.10837231
47MP0002108_abnormal_muscle_morphology1.09258413
48MP0003385_abnormal_body_wall1.08946758
49MP0001293_anophthalmia1.08778887
50MP0002160_abnormal_reproductive_system1.08059036
51MP0005670_abnormal_white_adipose1.07671484
52MP0002098_abnormal_vibrissa_morphology1.04819575
53MP0003329_amyloid_beta_deposits1.04524957
54MP0001486_abnormal_startle_reflex1.02738100
55MP0010630_abnormal_cardiac_muscle1.00352701
56MP0002184_abnormal_innervation1.00328222
57MP0004087_abnormal_muscle_fiber0.99995444
58MP0003121_genomic_imprinting0.98986287
59MP0003635_abnormal_synaptic_transmissio0.97559116
60MP0002796_impaired_skin_barrier0.95760764
61MP0002092_abnormal_eye_morphology0.93444661
62MP0002882_abnormal_neuron_morphology0.91949181
63MP0002152_abnormal_brain_morphology0.91105754
64MP0000762_abnormal_tongue_morphology0.89352516
65MP0008789_abnormal_olfactory_epithelium0.88458512
66MP0009703_decreased_birth_body0.88375880
67MP0002233_abnormal_nose_morphology0.87292046
68MP0002638_abnormal_pupillary_reflex0.85914135
69MP0004130_abnormal_muscle_cell0.85670429
70MP0002063_abnormal_learning/memory/cond0.85227904
71MP0003935_abnormal_craniofacial_develop0.84709467
72MP0002081_perinatal_lethality0.84699682
73MP0002089_abnormal_postnatal_growth/wei0.84530738
74MP0003115_abnormal_respiratory_system0.83484680
75MP0009672_abnormal_birth_weight0.83267084
76MP0001849_ear_inflammation0.81027877
77MP0010678_abnormal_skin_adnexa0.80486593
78MP0003938_abnormal_ear_development0.80414035
79MP0006276_abnormal_autonomic_nervous0.79708525
80MP0004811_abnormal_neuron_physiology0.79650503
81MP0002116_abnormal_craniofacial_bone0.78689303
82MP0000516_abnormal_urinary_system0.78615027
83MP0005367_renal/urinary_system_phenotyp0.78615027
84MP0003948_abnormal_gas_homeostasis0.77623520
85MP0000432_abnormal_head_morphology0.74862669
86MP0003755_abnormal_palate_morphology0.74568066
87MP0005666_abnormal_adipose_tissue0.74331110
88MP0005275_abnormal_skin_tensile0.74212625
89MP0003453_abnormal_keratinocyte_physiol0.74116678
90MP0000383_abnormal_hair_follicle0.73857319
91MP0003567_abnormal_fetal_cardiomyocyte0.73274984
92MP0000377_abnormal_hair_follicle0.72896832
93MP0002557_abnormal_social/conspecific_i0.71612861
94MP0001727_abnormal_embryo_implantation0.71507620
95MP0003634_abnormal_glial_cell0.70694231
96MP0002084_abnormal_developmental_patter0.70168795
97MP0003937_abnormal_limbs/digits/tail_de0.69556719
98MP0003632_abnormal_nervous_system0.69366595
99MP0005423_abnormal_somatic_nervous0.69162302
100MP0004036_abnormal_muscle_relaxation0.68913927

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)2.98785242
2Right ventricular cardiomyopathy (HP:0011663)2.82598254
3High anterior hairline (HP:0009890)2.75166366
4Cerebral aneurysm (HP:0004944)2.70476087
5Popliteal pterygium (HP:0009756)2.34344038
6Heterotopia (HP:0002282)2.28534978
7Turricephaly (HP:0000262)2.26971485
8Aplasia involving bones of the upper limbs (HP:0009823)2.24859907
9Aplasia of the phalanges of the hand (HP:0009802)2.24859907
10Aplasia involving bones of the extremities (HP:0009825)2.24859907
11Bronchomalacia (HP:0002780)2.22108780
12Action tremor (HP:0002345)2.22062071
13Ulnar bowing (HP:0003031)2.21258865
14Fetal akinesia sequence (HP:0001989)2.20719477
15Germ cell neoplasia (HP:0100728)2.19660890
16Shallow orbits (HP:0000586)2.16460414
17Pterygium (HP:0001059)2.16016006
18Asymmetry of the thorax (HP:0001555)2.12369022
19Abnormality of the aortic arch (HP:0012303)2.12016485
20Thickened helices (HP:0000391)2.11635737
21Absent eyebrow (HP:0002223)2.08295541
22Choanal stenosis (HP:0000452)2.05188821
23Bilateral sensorineural hearing impairment (HP:0008619)2.03213935
24Thin ribs (HP:0000883)2.00779201
25Abnormality of the salivary glands (HP:0010286)1.97222034
26Dysmetric saccades (HP:0000641)1.96104210
27Precocious puberty (HP:0000826)1.95141601
28Macroorchidism (HP:0000053)1.94951526
29Vertebral arch anomaly (HP:0008438)1.90896306
30Cutaneous finger syndactyly (HP:0010554)1.89549349
31Difficulty running (HP:0009046)1.86941500
32Hepatoblastoma (HP:0002884)1.82876755
33Aplasia of the musculature (HP:0100854)1.81172300
34Bell-shaped thorax (HP:0001591)1.81061832
35Cutaneous syndactyly (HP:0012725)1.81039353
36Sudden death (HP:0001699)1.80906284
37Myokymia (HP:0002411)1.80184606
38Partial agenesis of the corpus callosum (HP:0001338)1.79728776
39Abnormality of the distal phalanx of the thumb (HP:0009617)1.79372047
40Ulnar deviation of the wrist (HP:0003049)1.78856467
41Morphological abnormality of the middle ear (HP:0008609)1.78345919
42Hyporeflexia of lower limbs (HP:0002600)1.78102141
43Neurofibrillary tangles (HP:0002185)1.77108331
44Abnormality of the lower motor neuron (HP:0002366)1.76945694
45Coronal craniosynostosis (HP:0004440)1.76815174
46Hyperacusis (HP:0010780)1.76078836
47Round ear (HP:0100830)1.75351189
48Lymphangioma (HP:0100764)1.75082831
49Intellectual disability, moderate (HP:0002342)1.74795726
50Sleep apnea (HP:0010535)1.73304645
51Midline defect of the nose (HP:0004122)1.72946547
52Abnormality of the fingertips (HP:0001211)1.72707489
53Bicornuate uterus (HP:0000813)1.72490209
54Hypoplasia of the iris (HP:0007676)1.72058993
55Alacrima (HP:0000522)1.71775188
56Abnormality of permanent molar morphology (HP:0011071)1.71525996
57Abnormality of the dental root (HP:0006486)1.71525996
58Taurodontia (HP:0000679)1.71525996
59Advanced eruption of teeth (HP:0006288)1.69726311
60Osteomalacia (HP:0002749)1.69442483
61Shawl scrotum (HP:0000049)1.69345636
62Abnormality of the ischium (HP:0003174)1.69241690
63Mitral valve prolapse (HP:0001634)1.69221915
64Increased connective tissue (HP:0009025)1.69109984
65Visceral angiomatosis (HP:0100761)1.68296987
66Truncal obesity (HP:0001956)1.66499840
67Distal lower limb muscle weakness (HP:0009053)1.66462879
68Akinesia (HP:0002304)1.65691307
69Absent eyelashes (HP:0000561)1.65577037
70Muscle fiber splitting (HP:0003555)1.65537650
71Overgrowth (HP:0001548)1.64561596
72Omphalocele (HP:0001539)1.63341125
73Myelomeningocele (HP:0002475)1.63111397
74Metaphyseal cupping (HP:0003021)1.60894980
75Exotropia (HP:0000577)1.60266289
76Hammertoe (HP:0001765)1.58154356
77Hemangiomatosis (HP:0007461)1.57931154
78Arnold-Chiari malformation (HP:0002308)1.57561241
79Abnormality of molar (HP:0011077)1.56925909
80Abnormality of molar morphology (HP:0011070)1.56925909
81Depression (HP:0000716)1.56749557
82Cerebral inclusion bodies (HP:0100314)1.56516430
83Laryngomalacia (HP:0001601)1.56400949
84Mask-like facies (HP:0000298)1.56283339
85Bundle branch block (HP:0011710)1.55547603
86Disproportionate tall stature (HP:0001519)1.53232338
87Ventricular tachycardia (HP:0004756)1.51002126
88Abnormality of the lacrimal duct (HP:0011481)1.46225658
89Flat acetabular roof (HP:0003180)1.46128632
90Abnormality of the dental pulp (HP:0006479)1.45877594
91Foot dorsiflexor weakness (HP:0009027)1.44400414
92Neoplasm of the heart (HP:0100544)1.44368479
93Broad metatarsal (HP:0001783)1.43815707
94Severe Myopia (HP:0011003)1.43490536
95Curly hair (HP:0002212)1.43253680
96Mildly elevated creatine phosphokinase (HP:0008180)1.43128297
97Menstrual irregularities (HP:0000858)1.43054906
98Neonatal hypoglycemia (HP:0001998)1.42593739
99Syncope (HP:0001279)1.42334461
100Skull defect (HP:0001362)1.41303139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.87372110
2PNCK3.01086379
3LATS22.84884725
4MARK12.53864085
5TRIB32.38409400
6ICK2.32980406
7CAMK1G2.26716740
8RIPK12.23156522
9LATS12.21057444
10AKT32.20837767
11EPHB22.18944904
12CDK121.93389521
13CAMK1D1.82359387
14EPHA21.81948640
15CASK1.80231609
16EEF2K1.76111667
17CDK91.71705231
18FGFR21.68106911
19MARK21.48846073
20NTRK11.45889697
21SGK4941.41027512
22SGK2231.41027512
23SGK21.40143944
24SGK31.30726916
25MAP3K91.30057642
26MTOR1.27976307
27MET1.24819888
28SIK11.20088803
29NLK1.19017198
30DDR21.16640343
31RPS6KA21.16249470
32PTK21.15808575
33MAP3K61.15003800
34PKN21.14418361
35EPHA31.12234535
36MAPK151.12026083
37PDGFRA1.08363337
38MUSK1.07979965
39NTRK21.05087705
40SMG11.03329055
41EPHB11.00754533
42DYRK21.00082334
43STK38L0.99223441
44LMTK20.98299206
45TYRO30.95908429
46PRKD30.94726662
47TTN0.92954318
48MAP3K100.92350263
49STK390.88997697
50STK380.87283843
51BRAF0.86676778
52MAP3K70.86601187
53RET0.80155303
54MAP2K40.79075789
55FGFR10.77729356
56STK110.76812225
57CDC42BPA0.76589797
58NME10.75601130
59TTK0.74567587
60WNK10.73535143
61EPHA40.73209194
62CDK50.71702132
63DYRK1B0.69312072
64FGFR40.68931939
65MINK10.66867056
66BRD40.64238148
67MST1R0.63866292
68PRKCZ0.63281948
69PRKAA10.62834038
70PTK60.62451132
71CAMK40.61164557
72NTRK30.59837393
73WNK40.59741215
74PHKG10.59466494
75PHKG20.59466494
76DMPK0.58378151
77FER0.58145925
78UHMK10.55062221
79MAP3K40.54717230
80TAOK10.53756406
81PRKD20.53212383
82MAPK100.52626533
83PDGFRB0.52169375
84ERBB20.51309873
85MAP2K70.51068731
86PAK30.48615119
87RPS6KL10.47051237
88RPS6KC10.47051237
89CSNK1E0.46771467
90RPS6KB10.46630863
91PDPK10.45931713
92ROCK20.45224816
93CAMK10.44657772
94NEK60.44036407
95YES10.43101027
96DYRK1A0.42293438
97PAK40.40830751
98GSK3B0.39188739
99SGK10.38457540
100MAP2K20.37204863

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045201.93358551
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86977429
3Axon guidance_Homo sapiens_hsa043601.73838721
4Basal cell carcinoma_Homo sapiens_hsa052171.69846702
5Notch signaling pathway_Homo sapiens_hsa043301.68243387
6Tight junction_Homo sapiens_hsa045301.66048336
7Thyroid hormone signaling pathway_Homo sapiens_hsa049191.62985975
8Thyroid cancer_Homo sapiens_hsa052161.62943218
9Endometrial cancer_Homo sapiens_hsa052131.61007960
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51368535
11Dilated cardiomyopathy_Homo sapiens_hsa054141.51087669
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50493615
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49662034
14Hippo signaling pathway_Homo sapiens_hsa043901.48189649
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47345629
16Hedgehog signaling pathway_Homo sapiens_hsa043401.46972836
17Melanogenesis_Homo sapiens_hsa049161.41558951
18ECM-receptor interaction_Homo sapiens_hsa045121.38690622
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31575313
20Gap junction_Homo sapiens_hsa045401.29633294
21Cocaine addiction_Homo sapiens_hsa050301.21584699
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20754110
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19885089
24Nicotine addiction_Homo sapiens_hsa050331.18366617
25ErbB signaling pathway_Homo sapiens_hsa040121.17504451
26Focal adhesion_Homo sapiens_hsa045101.14501399
27Wnt signaling pathway_Homo sapiens_hsa043101.13774022
28AMPK signaling pathway_Homo sapiens_hsa041521.13281694
29Lysine degradation_Homo sapiens_hsa003101.12392954
30Renal cell carcinoma_Homo sapiens_hsa052111.10599565
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09185662
32GnRH signaling pathway_Homo sapiens_hsa049121.06719606
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06362439
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05789260
35Estrogen signaling pathway_Homo sapiens_hsa049151.05522837
36Vitamin digestion and absorption_Homo sapiens_hsa049771.03665807
37Synaptic vesicle cycle_Homo sapiens_hsa047211.03636553
38Ovarian steroidogenesis_Homo sapiens_hsa049131.03213934
39Long-term potentiation_Homo sapiens_hsa047201.01696528
40Colorectal cancer_Homo sapiens_hsa052100.98088526
41Insulin signaling pathway_Homo sapiens_hsa049100.97447765
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97312196
43VEGF signaling pathway_Homo sapiens_hsa043700.92866036
44Choline metabolism in cancer_Homo sapiens_hsa052310.92621667
45Dopaminergic synapse_Homo sapiens_hsa047280.92340343
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92121087
47Chronic myeloid leukemia_Homo sapiens_hsa052200.91447003
48Prostate cancer_Homo sapiens_hsa052150.91243295
49Rap1 signaling pathway_Homo sapiens_hsa040150.90971585
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.90008250
51Thyroid hormone synthesis_Homo sapiens_hsa049180.89840215
52Inositol phosphate metabolism_Homo sapiens_hsa005620.89804085
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88760493
54Glutamatergic synapse_Homo sapiens_hsa047240.86370455
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85943286
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.85806934
57Histidine metabolism_Homo sapiens_hsa003400.84160261
58Cholinergic synapse_Homo sapiens_hsa047250.83992246
59mTOR signaling pathway_Homo sapiens_hsa041500.83440163
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.80713145
61Amoebiasis_Homo sapiens_hsa051460.80294388
62Gastric acid secretion_Homo sapiens_hsa049710.79905430
63Dorso-ventral axis formation_Homo sapiens_hsa043200.79866581
64Long-term depression_Homo sapiens_hsa047300.79639632
65Proteoglycans in cancer_Homo sapiens_hsa052050.79004429
66Insulin secretion_Homo sapiens_hsa049110.78575212
67Bile secretion_Homo sapiens_hsa049760.78467982
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78206564
69Glioma_Homo sapiens_hsa052140.77937772
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77250368
71Circadian entrainment_Homo sapiens_hsa047130.76791143
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75849644
73Glucagon signaling pathway_Homo sapiens_hsa049220.75577820
74Type II diabetes mellitus_Homo sapiens_hsa049300.74784115
75MicroRNAs in cancer_Homo sapiens_hsa052060.70000787
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69814204
77Ras signaling pathway_Homo sapiens_hsa040140.69648212
78GABAergic synapse_Homo sapiens_hsa047270.69607479
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69069786
80Pathways in cancer_Homo sapiens_hsa052000.68114030
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68013817
82cAMP signaling pathway_Homo sapiens_hsa040240.67633132
83Acute myeloid leukemia_Homo sapiens_hsa052210.67184770
84Oxytocin signaling pathway_Homo sapiens_hsa049210.65209401
85Amphetamine addiction_Homo sapiens_hsa050310.64619401
86Non-small cell lung cancer_Homo sapiens_hsa052230.64597433
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64040984
88Galactose metabolism_Homo sapiens_hsa000520.61200106
89Protein digestion and absorption_Homo sapiens_hsa049740.60483549
90Insulin resistance_Homo sapiens_hsa049310.60476375
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60212438
92MAPK signaling pathway_Homo sapiens_hsa040100.59907400
93Morphine addiction_Homo sapiens_hsa050320.59785239
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58931149
95Renin secretion_Homo sapiens_hsa049240.58304151
96Phenylalanine metabolism_Homo sapiens_hsa003600.58049046
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.57488608
98Endocytosis_Homo sapiens_hsa041440.57263264
99Circadian rhythm_Homo sapiens_hsa047100.57123604
100Prion diseases_Homo sapiens_hsa050200.56676867

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