ANKS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of oligodendrocyte differentiation (GO:0048715)9.83725074
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)9.79214445
3negative regulation of amyloid precursor protein catabolic process (GO:1902992)8.69694160
4negative regulation of Notch signaling pathway (GO:0045746)8.31333346
5regulation of synaptic vesicle exocytosis (GO:2000300)6.90378886
6regulation of vesicle fusion (GO:0031338)6.59047214
7regulation of beta-amyloid formation (GO:1902003)6.53315813
8regulation of type B pancreatic cell apoptotic process (GO:2000674)6.50401248
9regulation of apoptotic cell clearance (GO:2000425)6.14803429
10behavioral response to nicotine (GO:0035095)6.10390038
11regulation of synaptic vesicle transport (GO:1902803)6.06174526
12positive thymic T cell selection (GO:0045059)6.01294584
13regulation of transcription involved in cell fate commitment (GO:0060850)5.87182682
14heparan sulfate proteoglycan biosynthetic process (GO:0015012)5.86158213
15negative regulation of glycoprotein biosynthetic process (GO:0010561)5.79403972
16regulation of amyloid precursor protein catabolic process (GO:1902991)5.54779908
17phospholipid scrambling (GO:0017121)5.27114030
18ionotropic glutamate receptor signaling pathway (GO:0035235)5.16676277
19pyrimidine dimer repair (GO:0006290)5.00493786
20positive T cell selection (GO:0043368)4.91221330
21negative regulation of glial cell differentiation (GO:0045686)4.77145755
22regulation of cellular amide metabolic process (GO:0034248)4.72910630
23regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.65879466
24phospholipid efflux (GO:0033700)4.60265427
25proximal/distal pattern formation (GO:0009954)4.57797297
26nonmotile primary cilium assembly (GO:0035058)4.53059582
27negative regulation of glycoprotein metabolic process (GO:1903019)4.34203094
28regulation of oligodendrocyte differentiation (GO:0048713)4.33577701
29protein autoprocessing (GO:0016540)4.25839290
30maintenance of protein localization in organelle (GO:0072595)4.19745915
31regulation of NFAT protein import into nucleus (GO:0051532)4.12321202
32L-fucose catabolic process (GO:0042355)4.01991953
33fucose catabolic process (GO:0019317)4.01991953
34L-fucose metabolic process (GO:0042354)4.01991953
35regulation of metalloenzyme activity (GO:0048552)3.95541537
36response to pheromone (GO:0019236)3.93849372
37positive regulation of myoblast differentiation (GO:0045663)3.90179039
38positive regulation of cholesterol efflux (GO:0010875)3.83900144
39microtubule depolymerization (GO:0007019)3.83602032
40positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.81887254
41synaptic transmission, glutamatergic (GO:0035249)3.81710548
42positive regulation of vasculogenesis (GO:2001214)3.78579467
43regulation of gamma-delta T cell differentiation (GO:0045586)3.65233917
44heparan sulfate proteoglycan metabolic process (GO:0030201)3.59546591
45negative regulation of gliogenesis (GO:0014014)3.56596451
46regulation of Notch signaling pathway (GO:0008593)3.56231785
47body morphogenesis (GO:0010171)3.54918705
48positive regulation by host of viral transcription (GO:0043923)3.53614441
49embryonic body morphogenesis (GO:0010172)3.52993790
50nucleosome disassembly (GO:0006337)3.52771517
51protein-DNA complex disassembly (GO:0032986)3.52771517
52histone H3-K4 trimethylation (GO:0080182)3.50551155
53peptidyl-histidine modification (GO:0018202)3.46938503
54protein polyglutamylation (GO:0018095)3.45820343
55glutamate receptor signaling pathway (GO:0007215)3.45592389
56establishment of planar polarity (GO:0001736)3.44669300
57establishment of tissue polarity (GO:0007164)3.44669300
58kynurenine metabolic process (GO:0070189)3.42194070
59regulation of gamma-delta T cell activation (GO:0046643)3.41292924
60pyrimidine nucleobase catabolic process (GO:0006208)3.39581790
61regulation of synapse structural plasticity (GO:0051823)3.38904009
62urinary tract smooth muscle contraction (GO:0014848)3.38628198
63response to UV-B (GO:0010224)3.35787084
64receptor clustering (GO:0043113)3.34597472
65cellular response to fluid shear stress (GO:0071498)3.31058540
66axoneme assembly (GO:0035082)3.30065881
67cellular response to ATP (GO:0071318)3.29049355
68vitamin A metabolic process (GO:0006776)3.28950711
69regulation of action potential (GO:0098900)3.28586539
70regulation of cilium movement (GO:0003352)3.27932187
71negative regulation of cytosolic calcium ion concentration (GO:0051481)3.27481818
72oxidative phosphorylation (GO:0006119)3.26574098
73negative regulation of anoikis (GO:2000811)3.25599924
74positive regulation of sterol transport (GO:0032373)3.24640893
75positive regulation of cholesterol transport (GO:0032376)3.24640893
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21182286
77glycerophospholipid catabolic process (GO:0046475)3.21089925
78plasma lipoprotein particle assembly (GO:0034377)3.20062599
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.19577084
80histone H2B ubiquitination (GO:0033523)3.19098488
81preassembly of GPI anchor in ER membrane (GO:0016254)3.18923646
82thymic T cell selection (GO:0045061)3.17859842
83positive regulation of axonogenesis (GO:0050772)3.13551783
84detection of light stimulus involved in visual perception (GO:0050908)3.13424380
85detection of light stimulus involved in sensory perception (GO:0050962)3.13424380
86cell migration in hindbrain (GO:0021535)3.11904292
87cell communication by electrical coupling (GO:0010644)3.10954155
88DNA deamination (GO:0045006)3.08650374
89synaptic vesicle maturation (GO:0016188)3.08478348
90negative regulation of organelle assembly (GO:1902116)3.08085617
91piRNA metabolic process (GO:0034587)3.07850821
92exploration behavior (GO:0035640)3.07099108
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.06675704
94negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06083609
95activation of protein kinase A activity (GO:0034199)3.05380721
96opioid receptor signaling pathway (GO:0038003)3.03572415
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03222834
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02587573
99epithelial cilium movement (GO:0003351)3.00994639
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00794597
101cornea development in camera-type eye (GO:0061303)3.00603265
102behavioral response to ethanol (GO:0048149)3.00197714
103gamma-aminobutyric acid transport (GO:0015812)2.99745137
104resolution of meiotic recombination intermediates (GO:0000712)2.98943329
105locomotory exploration behavior (GO:0035641)2.98838558
106adaptation of signaling pathway (GO:0023058)2.96529728
107nodal signaling pathway (GO:0038092)2.96322218
108hippocampus development (GO:0021766)2.95945123
109proteoglycan biosynthetic process (GO:0030166)2.95342220
110regulation of postsynaptic membrane potential (GO:0060078)2.94726003
111misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.94161128
112monoubiquitinated protein deubiquitination (GO:0035520)2.93895671
113neuromuscular synaptic transmission (GO:0007274)2.93867410
114protein-lipid complex assembly (GO:0065005)2.93124629
115base-excision repair, AP site formation (GO:0006285)2.92738927
116positive regulation of respiratory burst (GO:0060267)2.92704282
117regulation of nuclear cell cycle DNA replication (GO:0033262)2.90270787
118protein import into peroxisome matrix (GO:0016558)2.89364173
119protein hydroxylation (GO:0018126)2.88572459
120cilium or flagellum-dependent cell motility (GO:0001539)2.88406872
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87623707
122T cell selection (GO:0045058)2.87201614
123tryptophan catabolic process (GO:0006569)2.86361601
124indole-containing compound catabolic process (GO:0042436)2.86361601
125indolalkylamine catabolic process (GO:0046218)2.86361601
126regulation of neurotransmitter secretion (GO:0046928)2.86266726
127auditory behavior (GO:0031223)2.85688693
128ubiquinone biosynthetic process (GO:0006744)2.85354806
129regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84999626
130positive regulation of macroautophagy (GO:0016239)2.84958241
131indolalkylamine metabolic process (GO:0006586)2.83898596
132cellular response to glucose stimulus (GO:0071333)2.82937711
133regulation of microtubule-based movement (GO:0060632)2.82414766
134DNA methylation involved in gamete generation (GO:0043046)2.82282477
135negative regulation of telomere maintenance (GO:0032205)2.82050833
136synaptic vesicle docking involved in exocytosis (GO:0016081)2.81866034
137regulation of anoikis (GO:2000209)2.81100598
138cellular response to hexose stimulus (GO:0071331)2.79417677
139histone H3-K36 demethylation (GO:0070544)2.75582946
140positive regulation of fatty acid transport (GO:2000193)2.74482133
141synaptic transmission, cholinergic (GO:0007271)2.73720745
142cilium movement (GO:0003341)2.73674230
143mannosylation (GO:0097502)2.72908248
144tRNA modification (GO:0006400)2.71645511
145negative regulation of myotube differentiation (GO:0010832)2.71614019
146response to misfolded protein (GO:0051788)2.71449234
147negative regulation of purine nucleotide catabolic process (GO:0033122)2.71407508
148rRNA catabolic process (GO:0016075)2.71350994
149phosphatidylglycerol biosynthetic process (GO:0006655)2.71346724
150head development (GO:0060322)2.71314583
151histone H3-K9 demethylation (GO:0033169)2.71221607
152cellular ketone body metabolic process (GO:0046950)2.70735793
153regulation of cholesterol efflux (GO:0010874)2.70664875
154negative regulation of mast cell activation (GO:0033004)2.69828092
155ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.68374469
156metallo-sulfur cluster assembly (GO:0031163)2.67791896
157iron-sulfur cluster assembly (GO:0016226)2.67791896
158cilium morphogenesis (GO:0060271)2.65812501
159mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64448826
160mitochondrial respiratory chain complex I assembly (GO:0032981)2.64448826
161NADH dehydrogenase complex assembly (GO:0010257)2.64448826
162establishment of mitochondrion localization (GO:0051654)2.63735001
163ubiquinone metabolic process (GO:0006743)2.62701574
164regulation of hippo signaling (GO:0035330)2.62014496
165protein-cofactor linkage (GO:0018065)2.61514940
166protein localization to cilium (GO:0061512)2.61197124
167protein complex biogenesis (GO:0070271)2.60797241
168respiratory chain complex IV assembly (GO:0008535)2.59596952
169nucleobase catabolic process (GO:0046113)2.58558741
170L-methionine biosynthetic process (GO:0071265)2.57665012
171amino acid salvage (GO:0043102)2.57665012
172L-methionine salvage (GO:0071267)2.57665012
173sulfation (GO:0051923)2.57577468
174neuronal action potential (GO:0019228)2.57097619
175fucosylation (GO:0036065)2.55974466
176motile cilium assembly (GO:0044458)2.55969444
177G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54276905
178tryptophan metabolic process (GO:0006568)2.51027876
179nephron tubule morphogenesis (GO:0072078)2.50698187
180nephron epithelium morphogenesis (GO:0072088)2.50698187
181sympathetic nervous system development (GO:0048485)2.50114936
182meiotic chromosome segregation (GO:0045132)2.49785191
183cilium organization (GO:0044782)2.49289504
184reciprocal meiotic recombination (GO:0007131)2.49209464
185reciprocal DNA recombination (GO:0035825)2.49209464
186pseudouridine synthesis (GO:0001522)2.48485715
187replication fork processing (GO:0031297)2.47928097
188positive regulation of protein kinase C signaling (GO:0090037)2.47464506
189spinal cord motor neuron differentiation (GO:0021522)2.47381896
190cardiovascular system development (GO:0072358)2.47186219
191regulation of neurotransmitter uptake (GO:0051580)2.46159008
192cilium assembly (GO:0042384)2.45471372
193amine catabolic process (GO:0009310)2.45306727
194protein retention in ER lumen (GO:0006621)10.6574920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.66246098
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.50410482
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76143332
4ZNF274_21170338_ChIP-Seq_K562_Hela3.47408650
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.05286415
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.82447274
7VDR_22108803_ChIP-Seq_LS180_Human2.72316718
8MYC_22102868_ChIP-Seq_BL_Human2.63988014
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60657886
10LXR_22292898_ChIP-Seq_THP-1_Human2.56735995
11EZH2_22144423_ChIP-Seq_EOC_Human2.53841012
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44197099
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.42227598
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.40026401
15VDR_21846776_ChIP-Seq_THP-1_Human2.38721863
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32921761
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32426086
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25225360
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.16450543
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.16357385
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15817225
22TP53_20018659_ChIP-ChIP_R1E_Mouse2.13446020
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09009669
24KDM2B_26808549_Chip-Seq_DND41_Human2.06801090
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91735982
26OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.90455650
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88885629
28TCF7_22412390_ChIP-Seq_EML_Mouse1.84844999
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.84043261
30ERA_21632823_ChIP-Seq_H3396_Human1.83215621
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81715321
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.78108895
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77620806
34CIITA_25753668_ChIP-Seq_RAJI_Human1.76762117
35GBX2_23144817_ChIP-Seq_PC3_Human1.76731783
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.76601662
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.75883447
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.75462858
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71206959
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.70204581
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.70134148
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67954673
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67954673
44REST_21632747_ChIP-Seq_MESCs_Mouse1.67734117
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66987228
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63287127
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60639202
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58823174
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57841690
50KDM2B_26808549_Chip-Seq_K562_Human1.57042572
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56154526
52TP53_22573176_ChIP-Seq_HFKS_Human1.54847663
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.54833826
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53931145
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52655600
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.52648750
57IGF1R_20145208_ChIP-Seq_DFB_Human1.51379102
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.50436868
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50423071
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48801095
61IRF1_19129219_ChIP-ChIP_H3396_Human1.47964193
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47683920
63P68_20966046_ChIP-Seq_HELA_Human1.46610633
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46405095
65VDR_24763502_ChIP-Seq_THP-1_Human1.46397670
66PHF8_20622854_ChIP-Seq_HELA_Human1.44876566
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.44535585
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40684049
69* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40670564
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.39787814
71TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.39724220
72OCT4_20526341_ChIP-Seq_ESCs_Human1.39218052
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38425354
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37702761
75MYC_18940864_ChIP-ChIP_HL60_Human1.36236113
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36112334
77BCL6_27268052_Chip-Seq_Bcells_Human1.35890274
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.35477588
79UTX_26944678_Chip-Seq_JUKART_Human1.34537502
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.33313677
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33143034
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31772051
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31224423
84DROSHA_22980978_ChIP-Seq_HELA_Human1.30816120
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.30772534
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29804732
87RNF2_27304074_Chip-Seq_NSC_Mouse1.29380129
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28421562
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28328447
90GATA1_19941826_ChIP-Seq_K562_Human1.25769922
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25709308
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.25566957
93TAF2_19829295_ChIP-Seq_ESCs_Human1.25491361
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24927302
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24516584
96SOX3_22085726_ChIP-Seq_NPCs_Mouse1.24311751
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23361027
98FUS_26573619_Chip-Seq_HEK293_Human1.22993886
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22824281
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22677547
101SMC4_20622854_ChIP-Seq_HELA_Human1.22417060
102* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21902479
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.21775236
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21766099
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20981071
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20981071
107MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20133038
108EWS_26573619_Chip-Seq_HEK293_Human1.18538798
109TP53_23651856_ChIP-Seq_MEFs_Mouse1.18422813
110MYC_19829295_ChIP-Seq_ESCs_Human1.18035999
111OCT4_19829295_ChIP-Seq_ESCs_Human1.17088838
112FOXP1_21924763_ChIP-Seq_HESCs_Human1.16409249
113SPI1_20517297_ChIP-Seq_HL60_Human1.14938539
114ER_23166858_ChIP-Seq_MCF-7_Human1.14898179
115* GATA3_21878914_ChIP-Seq_MCF-7_Human1.14799200
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13953021
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13714750
118P53_21459846_ChIP-Seq_SAOS-2_Human1.13268162
119NANOG_20526341_ChIP-Seq_ESCs_Human1.13160648
120MAF_26560356_Chip-Seq_TH2_Human1.13041531
121ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12971965
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.12372996
123ELK3_25401928_ChIP-Seq_HUVEC_Human1.11723400
124TAF15_26573619_Chip-Seq_HEK293_Human1.11646581
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10450015
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10086070
127RAC3_21632823_ChIP-Seq_H3396_Human1.09981860
128* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08905446
129RNF2_27304074_Chip-Seq_ESCs_Mouse1.08902805
130* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08209260
131HOXB7_26014856_ChIP-Seq_BT474_Human1.07613535
132SCL_19346495_ChIP-Seq_HPC-7_Human1.07304205
133NCOR_22424771_ChIP-Seq_293T_Human1.06287229
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06267496
135RING1B_27294783_Chip-Seq_ESCs_Mouse1.05699483
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05418893
137SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05259116
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04800327
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04479884
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03842494
141MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03006141
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02889410
143* GABP_19822575_ChIP-Seq_HepG2_Human1.02385132
144FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02165398
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01516008
146BCAT_22108803_ChIP-Seq_LS180_Human1.01166004
147WDR5_24793694_ChIP-Seq_LNCAP_Human1.00750963
148YY1_21170310_ChIP-Seq_MESCs_Mouse1.00575120
149TET1_21490601_ChIP-Seq_MESCs_Mouse1.00570233
150AR_21572438_ChIP-Seq_LNCaP_Human0.98492930
151STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98055791
152SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95037988
153* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94856109
154BCOR_27268052_Chip-Seq_Bcells_Human0.94759053
155CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93856386
156FOXM1_23109430_ChIP-Seq_U2OS_Human0.93720395
157GABP_17652178_ChIP-ChIP_JURKAT_Human0.93582980
158TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93115448
159E2F1_20622854_ChIP-Seq_HELA_Human0.92372606
160VDR_23849224_ChIP-Seq_CD4+_Human0.92319074
161CTCF_27219007_Chip-Seq_Bcells_Human0.91143234
162CTCF_20526341_ChIP-Seq_ESCs_Human0.91004329
163TBX20_22080862_ChIP-Seq_HEART_Mouse0.89667212
164TBX20_22328084_ChIP-Seq_HEART_Mouse0.89667212
165GATA3_27048872_Chip-Seq_THYMUS_Human0.88429228
166E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88255601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.84071566
2MP0003011_delayed_dark_adaptation5.44753427
3MP0001270_distended_abdomen3.89436069
4MP0004859_abnormal_synaptic_plasticity3.60836708
5MP0008961_abnormal_basal_metabolism3.54202916
6MP0005394_taste/olfaction_phenotype3.39519363
7MP0005499_abnormal_olfactory_system3.39519363
8MP0009278_abnormal_bone_marrow3.30713301
9MP0008789_abnormal_olfactory_epithelium3.30194123
10MP0004043_abnormal_pH_regulation3.07426266
11MP0003693_abnormal_embryo_hatching2.88358335
12MP0002234_abnormal_pharynx_morphology2.62662114
13MP0001986_abnormal_taste_sensitivity2.52033142
14MP0005171_absent_coat_pigmentation2.43272576
15MP0005423_abnormal_somatic_nervous2.42592627
16MP0002736_abnormal_nociception_after2.37714543
17MP0002638_abnormal_pupillary_reflex2.33660150
18MP0006276_abnormal_autonomic_nervous2.20505714
19MP0003136_yellow_coat_color2.15470833
20MP0002733_abnormal_thermal_nociception2.02850964
21MP0002735_abnormal_chemical_nociception2.02776773
22MP0002102_abnormal_ear_morphology1.96108528
23MP0009745_abnormal_behavioral_response1.91727568
24MP0008875_abnormal_xenobiotic_pharmacok1.91062139
25MP0005220_abnormal_exocrine_pancreas1.90666573
26MP0001502_abnormal_circadian_rhythm1.89702438
27MP0004133_heterotaxia1.88306587
28MP0009046_muscle_twitch1.86821197
29MP0003635_abnormal_synaptic_transmissio1.86813607
30MP0000049_abnormal_middle_ear1.86254638
31MP0004142_abnormal_muscle_tone1.85033459
32MP0001486_abnormal_startle_reflex1.79893290
33MP0006035_abnormal_mitochondrial_morpho1.78169164
34MP0003787_abnormal_imprinting1.76536062
35MP0002064_seizures1.74365255
36MP0005076_abnormal_cell_differentiation1.71008715
37MP0004130_abnormal_muscle_cell1.69787755
38MP0001529_abnormal_vocalization1.66718084
39MP0000778_abnormal_nervous_system1.63206061
40MP0001968_abnormal_touch/_nociception1.60204091
41MP0000358_abnormal_cell_content/1.60198919
42MP0003646_muscle_fatigue1.58758122
43MP0000465_gastrointestinal_hemorrhage1.55391520
44MP0001188_hyperpigmentation1.52107364
45MP0005646_abnormal_pituitary_gland1.44698577
46MP0002160_abnormal_reproductive_system1.43923586
47MP0004808_abnormal_hematopoietic_stem1.43225840
48MP0001664_abnormal_digestion1.40274217
49MP0001905_abnormal_dopamine_level1.37819080
50MP0002938_white_spotting1.37738035
51MP0003878_abnormal_ear_physiology1.36176963
52MP0005377_hearing/vestibular/ear_phenot1.36176963
53MP0010329_abnormal_lipoprotein_level1.35340355
54MP0003195_calcinosis1.34910800
55MP0000427_abnormal_hair_cycle1.34550311
56MP0001485_abnormal_pinna_reflex1.33387508
57MP0004147_increased_porphyrin_level1.31708804
58MP0008872_abnormal_physiological_respon1.31698432
59MP0002876_abnormal_thyroid_physiology1.31136407
60MP0001970_abnormal_pain_threshold1.29890198
61MP0003122_maternal_imprinting1.28562850
62MP0000858_altered_metastatic_potential1.25182098
63MP0000631_abnormal_neuroendocrine_gland1.25088637
64MP0003283_abnormal_digestive_organ1.24616030
65MP0002734_abnormal_mechanical_nocicepti1.24230081
66MP0002909_abnormal_adrenal_gland1.22078405
67MP0005386_behavior/neurological_phenoty1.20770992
68MP0004924_abnormal_behavior1.20770992
69MP0010386_abnormal_urinary_bladder1.18995945
70MP0005551_abnormal_eye_electrophysiolog1.17551648
71MP0000538_abnormal_urinary_bladder1.17451521
72MP0005389_reproductive_system_phenotype1.16296608
73MP0005253_abnormal_eye_physiology1.14797469
74MP0002752_abnormal_somatic_nervous1.14531017
75MP0005397_hematopoietic_system_phenotyp1.11960321
76MP0001545_abnormal_hematopoietic_system1.11960321
77MP0005174_abnormal_tail_pigmentation1.11816672
78MP0002653_abnormal_ependyma_morphology1.11145286
79MP0001944_abnormal_pancreas_morphology1.08882207
80MP0001727_abnormal_embryo_implantation1.08789330
81MP0004811_abnormal_neuron_physiology1.08435287
82MP0003300_gastrointestinal_ulcer1.07713228
83MP0002184_abnormal_innervation1.06338488
84MP0000015_abnormal_ear_pigmentation1.06097841
85MP0005195_abnormal_posterior_eye1.06097215
86MP0000026_abnormal_inner_ear1.04399658
87MP0001984_abnormal_olfaction1.03794722
88MP0000003_abnormal_adipose_tissue1.01598007
89MP0008569_lethality_at_weaning0.99422580
90MP0002751_abnormal_autonomic_nervous0.99239348
91MP0001919_abnormal_reproductive_system0.96841761
92MP0002166_altered_tumor_susceptibility0.95935735
93MP0001963_abnormal_hearing_physiology0.95135060
94MP0001501_abnormal_sleep_pattern0.94713078
95MP0008995_early_reproductive_senescence0.92127313
96MP0000678_abnormal_parathyroid_gland0.91748572
97MP0005384_cellular_phenotype0.91533761
98MP0002837_dystrophic_cardiac_calcinosis0.91505731
99MP0002272_abnormal_nervous_system0.90513070
100MP0006072_abnormal_retinal_apoptosis0.88670371
101MP0009384_cardiac_valve_regurgitation0.88374406
102MP0006292_abnormal_olfactory_placode0.88015913
103MP0003698_abnormal_male_reproductive0.86610231
104MP0000569_abnormal_digit_pigmentation0.85853357
105MP0003119_abnormal_digestive_system0.85184243
106MP0003935_abnormal_craniofacial_develop0.84467407
107MP0002928_abnormal_bile_duct0.83826709
108MP0002152_abnormal_brain_morphology0.83041524
109MP0003077_abnormal_cell_cycle0.82594423
110MP0005410_abnormal_fertilization0.81527932
111MP0002882_abnormal_neuron_morphology0.81410357
112MP0002210_abnormal_sex_determination0.81000998
113MP0000383_abnormal_hair_follicle0.80969830
114MP0001756_abnormal_urination0.80332223
115MP0003937_abnormal_limbs/digits/tail_de0.80016620
116MP0000013_abnormal_adipose_tissue0.79771563
117MP0005621_abnormal_cell_physiology0.79651640
118MP0004885_abnormal_endolymph0.78952549
119MP0006036_abnormal_mitochondrial_physio0.78197248
120MP0000685_abnormal_immune_system0.77762759
121MP0009053_abnormal_anal_canal0.76695538
122MP0002063_abnormal_learning/memory/cond0.76006946
123MP0002067_abnormal_sensory_capabilities0.74081083
124MP0002557_abnormal_social/conspecific_i0.72218081
125MP0003045_fibrosis0.71673925
126MP0002877_abnormal_melanocyte_morpholog0.71573633
127MP0008874_decreased_physiological_sensi0.71559502
128MP0003879_abnormal_hair_cell0.70309034
129MP0005075_abnormal_melanosome_morpholog0.70079336
130MP0002572_abnormal_emotion/affect_behav0.69077160
131MP0005645_abnormal_hypothalamus_physiol0.68382889
132MP0000955_abnormal_spinal_cord0.67967166
133MP0003436_decreased_susceptibility_to0.67669097
134MP0000313_abnormal_cell_death0.67410953
135MP0000703_abnormal_thymus_morphology0.67325529
136MP0003880_abnormal_central_pattern0.66736130
137MP0002089_abnormal_postnatal_growth/wei0.66475861
138MP0001324_abnormal_eye_pigmentation0.65622269
139MP0002693_abnormal_pancreas_physiology0.65619331
140MP0003866_abnormal_defecation0.64123115
141MP0000751_myopathy0.63046178
142MP0002398_abnormal_bone_marrow0.62579062
143MP0009840_abnormal_foam_cell0.62332179
144MP0002069_abnormal_eating/drinking_beha0.62270164
145MP0008877_abnormal_DNA_methylation0.61790415
146MP0003329_amyloid_beta_deposits0.61733378
147MP0003705_abnormal_hypodermis_morpholog0.61254376
148MP0005584_abnormal_enzyme/coenzyme_acti0.60412886
149MP0008007_abnormal_cellular_replicative0.59508721
150MP0005409_darkened_coat_color0.59366799
151MP0003121_genomic_imprinting0.56861693
152MP0008260_abnormal_autophagy0.56440282
153MP0003943_abnormal_hepatobiliary_system0.55188403
154MP0002078_abnormal_glucose_homeostasis0.54929445
155MP0005391_vision/eye_phenotype0.54488557
156MP0002822_catalepsy0.54294343
157MP0001800_abnormal_humoral_immune0.53763073
158MP0003137_abnormal_impulse_conducting0.53590868

Predicted human phenotypes

RankGene SetZ-score
1Broad distal phalanx of finger (HP:0009836)9.64573359
2Patent foramen ovale (HP:0001655)6.63819865
3Cortical dysplasia (HP:0002539)5.53474749
4Rectal prolapse (HP:0002035)5.29707468
5Microretrognathia (HP:0000308)5.23183354
6Amblyopia (HP:0000646)5.07396334
7Gastrointestinal infarctions (HP:0005244)4.94577427
8Hypochromic anemia (HP:0001931)4.71601293
9Molar tooth sign on MRI (HP:0002419)4.61675593
10Abnormality of midbrain morphology (HP:0002418)4.61675593
11Abnormality of the fingertips (HP:0001211)4.58592525
12Aplasia/Hypoplasia of the sacrum (HP:0008517)4.39100444
13Congenital glaucoma (HP:0001087)4.29754418
14Pancreatic cysts (HP:0001737)4.24066230
15Nasal polyposis (HP:0100582)4.20289383
16Pancreatic fibrosis (HP:0100732)3.86786940
17Esophageal atresia (HP:0002032)3.82401349
18Congenital stationary night blindness (HP:0007642)3.73360317
19Nephronophthisis (HP:0000090)3.68771251
20Abnormality of the nasal mucosa (HP:0000433)3.67386253
21Medulloblastoma (HP:0002885)3.66221341
22Dilatation of the ascending aorta (HP:0005111)3.62540395
23Generalized hypotonia (HP:0001290)3.61603872
24True hermaphroditism (HP:0010459)3.58628104
25Biliary tract neoplasm (HP:0100574)3.54926177
26Metatarsus adductus (HP:0001840)3.54095449
27Rib fusion (HP:0000902)3.52536460
28Bicuspid aortic valve (HP:0001647)3.45844412
29Attenuation of retinal blood vessels (HP:0007843)3.32255315
30Chronic hepatic failure (HP:0100626)3.25295211
31Esophageal neoplasm (HP:0100751)3.20561642
32Neoplasm of head and neck (HP:0012288)3.20561642
33Esotropia (HP:0000565)3.19537212
34Cerebellar dysplasia (HP:0007033)3.17196712
35Abnormal biliary tract morphology (HP:0012440)3.02534243
36Broad thumb (HP:0011304)3.02385454
37Abnormality of the renal medulla (HP:0100957)2.98254860
38Germ cell neoplasia (HP:0100728)2.93593981
39Cystic liver disease (HP:0006706)2.91678840
40Mitral valve prolapse (HP:0001634)2.89235905
41Patellar aplasia (HP:0006443)2.84982066
42Tubular atrophy (HP:0000092)2.81752321
43Flat face (HP:0012368)2.78773023
44Aplasia/Hypoplasia of the patella (HP:0006498)2.75513422
45Colon cancer (HP:0003003)2.72974719
46Occipital encephalocele (HP:0002085)2.69958620
47Bony spicule pigmentary retinopathy (HP:0007737)2.66812437
48Medial flaring of the eyebrow (HP:0010747)2.66540522
49Elbow flexion contracture (HP:0002987)2.66129511
50Hyperventilation (HP:0002883)2.63152194
51Testicular neoplasm (HP:0010788)2.62687924
52Abnormal drinking behavior (HP:0030082)2.61773695
53Polydipsia (HP:0001959)2.61773695
54Abnormality of DNA repair (HP:0003254)2.61205603
55Concave nail (HP:0001598)2.61072677
56Anencephaly (HP:0002323)2.59926594
57Impaired proprioception (HP:0010831)2.56548397
58Hypoplasia of the pons (HP:0012110)2.55185055
59Neoplasm of the rectum (HP:0100743)2.55125278
60Broad-based gait (HP:0002136)2.52833867
61Lissencephaly (HP:0001339)2.52343455
62Broad phalanges of the hand (HP:0009768)2.52304691
63Abnormality of nail color (HP:0100643)2.49781859
64Focal seizures (HP:0007359)2.47947766
65Congenital sensorineural hearing impairment (HP:0008527)2.47320423
66Retinal dysplasia (HP:0007973)2.45556834
67Testicular atrophy (HP:0000029)2.44990991
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44331236
69Sclerocornea (HP:0000647)2.41322889
70Abnormal rod and cone electroretinograms (HP:0008323)2.41290570
71Abnormality of the pons (HP:0007361)2.40890782
72Gait imbalance (HP:0002141)2.40143191
73Protruding tongue (HP:0010808)2.40049320
74Gastrointestinal atresia (HP:0002589)2.38853085
75Cardiomegaly (HP:0001640)2.37760634
76Severe short stature (HP:0003510)2.34106051
77Decreased central vision (HP:0007663)2.32436041
78Congenital hepatic fibrosis (HP:0002612)2.32032230
79Chronic otitis media (HP:0000389)2.29567641
80Broad finger (HP:0001500)2.28521736
81Embryonal neoplasm (HP:0002898)2.27658103
82Genetic anticipation (HP:0003743)2.27185207
83Abnormality of the renal cortex (HP:0011035)2.24898559
84Postaxial foot polydactyly (HP:0001830)2.24698625
85Broad phalanx (HP:0006009)2.19572068
86Optic nerve coloboma (HP:0000588)2.18214640
87Severe muscular hypotonia (HP:0006829)2.18119441
88Congenital primary aphakia (HP:0007707)2.17511015
89Nephrogenic diabetes insipidus (HP:0009806)2.15901422
90Keratoconus (HP:0000563)2.15042977
91Increased corneal curvature (HP:0100692)2.15042977
92Neoplasm of the small intestine (HP:0100833)2.14443038
93Abolished electroretinogram (ERG) (HP:0000550)2.13687290
94Mesangial abnormality (HP:0001966)2.12829712
95Congenital diaphragmatic hernia (HP:0000776)2.11439366
96Breast carcinoma (HP:0003002)2.11375163
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10328040
98Bile duct proliferation (HP:0001408)2.10105554
99Abnormal biliary tract physiology (HP:0012439)2.10105554
100Failure to thrive in infancy (HP:0001531)2.10067779
101Ependymoma (HP:0002888)2.08819085
102Tachypnea (HP:0002789)2.06264683
103Broad long bones (HP:0005622)2.04247664
104Absent speech (HP:0001344)2.02702418
105Focal motor seizures (HP:0011153)2.02163081
106Polyuria (HP:0000103)2.02057287
107Preaxial hand polydactyly (HP:0001177)2.01121571
108Large eyes (HP:0001090)10.8370099
109Abnormality of alanine metabolism (HP:0010916)1.99397881
110Hyperalaninemia (HP:0003348)1.99397881
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99397881
112Inability to walk (HP:0002540)1.98671030
113Prominent metopic ridge (HP:0005487)1.95194658
114Accelerated skeletal maturation (HP:0005616)1.95062540
115Gonadal dysgenesis (HP:0000133)1.94977641
116Abnormality of the intervertebral disk (HP:0005108)1.94052691
117Chorioretinal atrophy (HP:0000533)1.93571049
118Absent/shortened dynein arms (HP:0200106)1.92648399
119Dynein arm defect of respiratory motile cilia (HP:0012255)1.92648399
120Gastrointestinal carcinoma (HP:0002672)1.92234974
121Malignant gastrointestinal tract tumors (HP:0006749)1.92234974
122Pachygyria (HP:0001302)1.91604405
123Type II lissencephaly (HP:0007260)1.90520389
124Hypochromic microcytic anemia (HP:0004840)1.89523281
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.88913735
126Epileptic encephalopathy (HP:0200134)1.87796781
127Thick eyebrow (HP:0000574)1.83814570
128Excessive salivation (HP:0003781)1.83471168
129Drooling (HP:0002307)1.83471168
130Narrow forehead (HP:0000341)1.82168537
131Clumsiness (HP:0002312)1.82001267
132Postaxial hand polydactyly (HP:0001162)1.81361072
133Hand muscle atrophy (HP:0009130)1.81275165
134Rectal fistula (HP:0100590)1.78568310
135Rectovaginal fistula (HP:0000143)1.78568310
136Truncal ataxia (HP:0002078)1.78069678
137Sandal gap (HP:0001852)1.77049146
138High pitched voice (HP:0001620)1.76567059
139Left ventricular hypertrophy (HP:0001712)1.76258731
140Brachycephaly (HP:0000248)1.75999213
141Loss of speech (HP:0002371)1.75878842
142Male pseudohermaphroditism (HP:0000037)1.75722567
143Meningocele (HP:0002435)1.75603869
144Bowel incontinence (HP:0002607)1.74828285
145Large for gestational age (HP:0001520)1.74719931
146Poor eye contact (HP:0000817)1.74295021
147Absent thumb (HP:0009777)1.74287242
148Impaired social interactions (HP:0000735)1.73381034
149Abnormal social behavior (HP:0012433)1.73381034
150Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73305601
151Spina bifida occulta (HP:0003298)1.73200275
152Optic disc pallor (HP:0000543)1.72669743
153Hepatocellular necrosis (HP:0001404)1.72389188
154Abnormality of the renal collecting system (HP:0004742)1.71690826
155Decreased circulating renin level (HP:0003351)1.71578198
156Retinitis pigmentosa (HP:0000510)1.71185767
157Progressive cerebellar ataxia (HP:0002073)1.70501888
158Gaze-evoked nystagmus (HP:0000640)1.70060588
159Cerebral aneurysm (HP:0004944)1.69978949
160Microtia (HP:0008551)1.69946680
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.69707986
162Hypoalbuminemia (HP:0003073)1.69355187
163Abnormal albumin level (HP:0012116)1.69355187
164Pendular nystagmus (HP:0012043)1.68988675
165Dandy-Walker malformation (HP:0001305)1.67807304
166Webbed neck (HP:0000465)1.67538939
167Highly arched eyebrow (HP:0002553)1.66813424
168Abnormal respiratory epithelium morphology (HP:0012253)1.66208682
169Abnormal respiratory motile cilium morphology (HP:0005938)1.66208682
170Intestinal polyposis (HP:0200008)1.65870189
171Mutism (HP:0002300)1.65241957
172Progressive inability to walk (HP:0002505)1.64475077
173Distal upper limb amyotrophy (HP:0007149)1.64324951
174Upper limb amyotrophy (HP:0009129)1.64324951
175Agitation (HP:0000713)1.64282769
176Neoplasm of the colon (HP:0100273)1.62688676
177Abnormality of the metopic suture (HP:0005556)1.62531104
178Intellectual disability, severe (HP:0010864)1.62435825
179Febrile seizures (HP:0002373)1.62122197
180Hemiparesis (HP:0001269)1.62078382
181Oligodactyly (hands) (HP:0001180)1.61680287
182Bulbous nose (HP:0000414)1.61415504
183Type 2 muscle fiber atrophy (HP:0003554)1.61210121
184Supranuclear gaze palsy (HP:0000605)1.60123619
185Abnormal EKG (HP:0003115)1.58336760
186Hyperextensible skin (HP:0000974)1.58230375
187Cerebellar hypoplasia (HP:0001321)1.57616440
188Cerebral palsy (HP:0100021)1.56269724
189Abnormality of vision evoked potentials (HP:0000649)1.54026432
190Intestinal polyp (HP:0005266)1.53049067
191Thrombocytosis (HP:0001894)1.52464063
192Abnormal large intestine physiology (HP:0012700)1.50210164
193Agnosia (HP:0010524)1.49896956
194Increased circulating renin level (HP:0000848)1.48837548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K7.31325006
2FRK4.52938870
3MAPKAPK34.18281856
4MAP3K23.84738546
5ADRBK23.30199896
6TIE13.17582279
7WNK43.14492951
8TLK13.02095437
9BRD42.92037501
10ACVR1B2.91658803
11ZAK2.82500758
12MAP3K42.73470792
13MAP2K42.70410023
14MAP2K72.64104114
15BMPR1B2.62988005
16MAP4K22.50672142
17MAP3K102.42865111
18TRPM72.20240791
19MARK12.08838121
20GRK12.07586576
21CASK2.02836376
22MAPK131.89526293
23MUSK1.88404608
24RPS6KA21.87199320
25PINK11.82911668
26MAPKAPK51.79695736
27MAP3K91.76907160
28MAP3K71.71069381
29ERN11.54133395
30RPS6KA41.39283543
31FES1.34057617
32TRIM281.32910964
33RPS6KB21.31185751
34ADRBK11.26348977
35NTRK31.19946163
36MAPK121.18085948
37CAMK1G1.17591306
38TAOK31.15357413
39OXSR11.15255747
40TSSK61.14461816
41MAPK151.13466874
42NUAK11.12427479
43KSR11.11094582
44PDK21.09647728
45STK391.09518035
46PRKCG1.09217931
47INSRR1.06423683
48TEC1.05780566
49MAP2K61.05454163
50MAP3K110.98460182
51STK160.95523472
52CAMK1D0.92006646
53CAMK10.91614044
54TYRO30.91471345
55MAPK70.91463946
56PKN10.91193438
57DAPK10.90081045
58RPS6KB10.88696581
59KIT0.88179539
60STK110.87189648
61PRKCI0.87025892
62RPS6KA50.84432038
63UHMK10.82961512
64PRKCQ0.82597611
65TTN0.82104046
66DYRK1A0.82004968
67LMTK20.81007065
68MARK20.80039053
69CSNK1G20.78309722
70MAPK110.77727780
71CSNK1G30.77003806
72MAP2K20.76783431
73PRKCZ0.76613079
74FGR0.76379982
75PRKD30.75822210
76MAP4K10.75179000
77CSNK1A1L0.73741479
78NME10.73088381
79PRKCE0.72903474
80DAPK20.72878718
81SIK30.71241962
82STK38L0.70012404
83TNK20.68084532
84PRKAA10.65942920
85MKNK20.65855824
86SIK20.63781857
87TXK0.63746348
88NEK20.63236262
89SGK4940.60817574
90SGK2230.60817574
91PRKD20.60736868
92FGFR30.60643322
93CSNK1G10.60384532
94TNIK0.58832955
95CSF1R0.58668597
96CAMKK10.58525844
97PIM20.57913760
98CDK120.57308372
99TGFBR10.57123204
100ITK0.56465527
101RPS6KL10.54822296
102RPS6KC10.54822296
103CHEK20.53568764
104MINK10.53283184
105PDGFRA0.53263395
106FGFR40.52164750
107TRIB30.51187659
108PRKCH0.51185781
109PIK3CG0.50782366
110HCK0.50670247
111PHKG20.50568577
112PHKG10.50568577
113CLK10.50110629
114CAMK40.49885918
115CHUK0.49809728
116ATR0.49764839
117PRKACA0.47111758
118BMX0.46201905
119STK380.45245445
120CSNK1A10.44673347
121RPS6KA10.44611163
122AURKA0.44260122
123RPS6KA60.43873328
124WNK30.42148332
125PLK20.42050184
126IKBKB0.41767621
127PLK10.41481280
128CSNK1D0.41179008
129ERBB20.40947243
130CDK50.40271405
131CAMK2A0.39731417
132TYK20.38107141
133DYRK20.37794634
134BTK0.37376001
135MAPK80.37298991
136PAK60.36431170
137EPHA40.36234614
138DYRK1B0.35436940
139TBK10.35403725
140SGK10.35307568
141PASK0.34031917
142FLT30.33869515
143TGFBR20.33655165
144BCKDK0.33082498
145NTRK20.32967040
146GRK60.31886879
147MTOR0.30801484
148CDK180.30699669
149PTK60.28943174
150CAMKK20.28608483
151PAK30.28549575
152SYK0.28088383
153MAP2K30.28037083
154CDK150.27936376

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.69629598
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005344.14110058
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.19677849
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.87595063
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69328807
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.57081510
7Linoleic acid metabolism_Homo sapiens_hsa005912.47349912
8Sulfur relay system_Homo sapiens_hsa041222.45951135
9ABC transporters_Homo sapiens_hsa020102.31540589
10Glutamatergic synapse_Homo sapiens_hsa047242.30580314
11Olfactory transduction_Homo sapiens_hsa047402.29852548
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24434345
13Type II diabetes mellitus_Homo sapiens_hsa049302.02604960
14Circadian entrainment_Homo sapiens_hsa047132.01470585
15Fanconi anemia pathway_Homo sapiens_hsa034601.98587085
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92263962
17GnRH signaling pathway_Homo sapiens_hsa049121.89530694
18Ether lipid metabolism_Homo sapiens_hsa005651.87659948
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86056890
20Selenocompound metabolism_Homo sapiens_hsa004501.84134722
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82251897
22Insulin secretion_Homo sapiens_hsa049111.81756984
23Nicotine addiction_Homo sapiens_hsa050331.81554802
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75521757
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75453537
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74550429
27Basal transcription factors_Homo sapiens_hsa030221.72967944
28RNA polymerase_Homo sapiens_hsa030201.65116880
29GABAergic synapse_Homo sapiens_hsa047271.63962907
30Morphine addiction_Homo sapiens_hsa050321.62105624
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.61252444
32Oxidative phosphorylation_Homo sapiens_hsa001901.58990295
33Systemic lupus erythematosus_Homo sapiens_hsa053221.57256985
34Nitrogen metabolism_Homo sapiens_hsa009101.56563237
35mTOR signaling pathway_Homo sapiens_hsa041501.53895218
36Cholinergic synapse_Homo sapiens_hsa047251.53005272
37Colorectal cancer_Homo sapiens_hsa052101.50841932
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50073425
39Alcoholism_Homo sapiens_hsa050341.48536847
40Gap junction_Homo sapiens_hsa045401.45427360
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.44613091
42Homologous recombination_Homo sapiens_hsa034401.37164026
43Oxytocin signaling pathway_Homo sapiens_hsa049211.31046212
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30492888
45Parkinsons disease_Homo sapiens_hsa050121.30027973
46Synaptic vesicle cycle_Homo sapiens_hsa047211.29372113
47Dopaminergic synapse_Homo sapiens_hsa047281.28850671
48Taste transduction_Homo sapiens_hsa047421.25473741
49Amphetamine addiction_Homo sapiens_hsa050311.22476749
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.22469717
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21255899
52Ovarian steroidogenesis_Homo sapiens_hsa049131.18986035
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18367386
54Cocaine addiction_Homo sapiens_hsa050301.15910447
55Gastric acid secretion_Homo sapiens_hsa049711.15084267
56Cardiac muscle contraction_Homo sapiens_hsa042601.14498943
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.12170523
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.12057804
59Regulation of autophagy_Homo sapiens_hsa041401.10611286
60Long-term potentiation_Homo sapiens_hsa047201.10093298
61Bile secretion_Homo sapiens_hsa049761.06815652
62RNA degradation_Homo sapiens_hsa030181.06547608
63Huntingtons disease_Homo sapiens_hsa050161.05325608
64Glycerophospholipid metabolism_Homo sapiens_hsa005641.05006846
65Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03726675
66Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00968051
67Renin secretion_Homo sapiens_hsa049241.00351593
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00110174
69Salivary secretion_Homo sapiens_hsa049700.99757229
70B cell receptor signaling pathway_Homo sapiens_hsa046620.99672040
71Primary immunodeficiency_Homo sapiens_hsa053400.99413996
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98940964
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93124486
74Thyroid hormone synthesis_Homo sapiens_hsa049180.87322765
75Estrogen signaling pathway_Homo sapiens_hsa049150.84422291
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84388644
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81816163
78Arachidonic acid metabolism_Homo sapiens_hsa005900.79537346
79AMPK signaling pathway_Homo sapiens_hsa041520.78544480
80Platelet activation_Homo sapiens_hsa046110.78474120
81Non-small cell lung cancer_Homo sapiens_hsa052230.77812009
82Basal cell carcinoma_Homo sapiens_hsa052170.77274202
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75740633
84Peroxisome_Homo sapiens_hsa041460.75491626
85Hedgehog signaling pathway_Homo sapiens_hsa043400.72666066
86Spliceosome_Homo sapiens_hsa030400.72369925
87Glycerolipid metabolism_Homo sapiens_hsa005610.71874399
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71629841
89Glioma_Homo sapiens_hsa052140.71162967
90Alzheimers disease_Homo sapiens_hsa050100.70193901
91Axon guidance_Homo sapiens_hsa043600.69482273
92cAMP signaling pathway_Homo sapiens_hsa040240.67379986
93Purine metabolism_Homo sapiens_hsa002300.65621618
94Insulin resistance_Homo sapiens_hsa049310.64871946
95Prolactin signaling pathway_Homo sapiens_hsa049170.64797874
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62515237
97Glucagon signaling pathway_Homo sapiens_hsa049220.62503986
98Serotonergic synapse_Homo sapiens_hsa047260.61814063
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61119071
100Phototransduction_Homo sapiens_hsa047440.60314170
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.60080901
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59696019
103Circadian rhythm_Homo sapiens_hsa047100.58888686
104Insulin signaling pathway_Homo sapiens_hsa049100.58580346
105Butanoate metabolism_Homo sapiens_hsa006500.57893088
106Notch signaling pathway_Homo sapiens_hsa043300.57534921
107Chronic myeloid leukemia_Homo sapiens_hsa052200.57234421
108Dorso-ventral axis formation_Homo sapiens_hsa043200.57040597
109Lysine degradation_Homo sapiens_hsa003100.56701994
110Choline metabolism in cancer_Homo sapiens_hsa052310.56229648
111Metabolic pathways_Homo sapiens_hsa011000.55584723
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.54863277
113Pyrimidine metabolism_Homo sapiens_hsa002400.54842844
114Chemical carcinogenesis_Homo sapiens_hsa052040.54780073
115Hippo signaling pathway_Homo sapiens_hsa043900.54658102
116ErbB signaling pathway_Homo sapiens_hsa040120.54249079
117MAPK signaling pathway_Homo sapiens_hsa040100.53563675
118Calcium signaling pathway_Homo sapiens_hsa040200.51312427
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50660337
120Osteoclast differentiation_Homo sapiens_hsa043800.50306924
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.50284757
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.49437482
123T cell receptor signaling pathway_Homo sapiens_hsa046600.48692243
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48610213
125Tryptophan metabolism_Homo sapiens_hsa003800.48590157
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47559648
127Caffeine metabolism_Homo sapiens_hsa002320.47438929
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46289319
129Pancreatic secretion_Homo sapiens_hsa049720.43872361
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43418397
131Pyruvate metabolism_Homo sapiens_hsa006200.43237816
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42112532
133VEGF signaling pathway_Homo sapiens_hsa043700.41244699
134Base excision repair_Homo sapiens_hsa034100.40328666
135Long-term depression_Homo sapiens_hsa047300.40076620
136Sphingolipid metabolism_Homo sapiens_hsa006000.39927745
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39754303
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.39746620
139Collecting duct acid secretion_Homo sapiens_hsa049660.39280782
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.39001779
141Protein export_Homo sapiens_hsa030600.38463036
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38409380
143beta-Alanine metabolism_Homo sapiens_hsa004100.38397774
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38290185
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38108054
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.37502678
147Toxoplasmosis_Homo sapiens_hsa051450.35982228
148Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35781789
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35605306
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35511688
151Pancreatic cancer_Homo sapiens_hsa052120.34682074
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34666979
153FoxO signaling pathway_Homo sapiens_hsa040680.34245355
154One carbon pool by folate_Homo sapiens_hsa006700.33651152
155Fatty acid biosynthesis_Homo sapiens_hsa000610.31749951
156Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30411936
157Histidine metabolism_Homo sapiens_hsa003400.30326801
158Propanoate metabolism_Homo sapiens_hsa006400.30208825
159Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29603391
160Steroid biosynthesis_Homo sapiens_hsa001000.25942601
161Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25849065

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